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O V Sirotkina, A B Laskovets, V V Goldobin, A A Topanova, D V Karelov, T V Vavilova
Cerebrovascular disease is a main cause of mortality and one of the big medical problems. After the vascular wall's damage the endothelial cells secrete the von Willebrand factor which then connects with its platelet's receptor GP Ib-V-IX. There are two polymorphisms Thr145Met and T(-5)C of the GP Iba gene associated with arterial thrombosis development. Also the difference in platelets' genes expressions was shown in patients with various clinical course of ischemic heart disease. The aim of this study was to investigate the role of platelet's receptor for von Willebrand factor in platelets' activation in patients with cerebrovascular disease...
September 2015: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
S G Khaspekova, I T Ziuriaev, V V Iakushkin, Ia A Naĭmushin, O V Sirotkina, N O Zaĭtseva, M Ia Ruda, A V Mazurov
Increased mean platelet volume (MPV) is an independent risk factor of thrombotic events in patients with cardiovascular diseases. Interactions of MPV with platelet aggregation activity and contents of glycoprotein (GP) IIb-IIIa (alphaIIb/beta3 integrin, fibrinogen receptor) and GP Ib (von Willebrand factor receptor) were investigated in this study. Investigation was performed in a group of healthy volunteers (n = 38) and in a group of patients with acute coronary syndrome (ACS). In patients blood was collected at days 1, 3-5 and 8-12 after ACS development...
January 2014: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
Svetlana G Khaspekova, Ilia T Zyuryaev, Vladimir V Yakushkin, Olga V Sirotkina, Natalia O Zaytseva, Mikhail Y Ruda, Mikhail A Panteleev, Alexey V Mazurov
Quantity of platelet adhesion molecules significantly varies in normal donors and cardiovascular patients and might be affected by platelet size and genetic variations. In this study, we assessed relationships of the content of glycoprotein (GP) IIb-IIIa and GPIb with mean platelet volume (MPV) and their genetic polymorphisms. MPV and GPIIb-IIIa and GPIb numbers were measured in 116 patients with acute coronary syndrome (ACS) at days 1, 3-5 and 8-12 after disease onset and in 32 healthy volunteers. GPIIb-IIIa and GPIb allelic variants were determined in ACS patients...
March 2014: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Naomasa Yamamoto, Noriko Akamatsu, Hitoshi Sakuraba, Kazuhiko Matsuno, Ryota Hosoya, Haruo Nogami, Kohji Kasahara, Susumu Mitsuyama, Morio Arai
A defective platelet glycoprotein (GP) Ib/IX/V complex [von Willebrand factor (VWF) receptor] results in Bernard-Soulier syndrome (BSS), which is characterized by macrothrombocytopenia and impaired ristocetin- and thrombin-induced platelet aggregation. We found 2 independent BSS-variant families: Case I [compound heterozygous mutations, p.Glu331X and a frame shift by a deletion at c.1444delA of GPIbα (GP1BA) terminating at a premature stop codon (p.Thr452ProfsX58)], and case II [homozygous nonsense mutation at c...
April 2013: Thrombosis Research
D M O Pruissen, L J Kappelle, F R Rosendaal, A Algra
OBJECTIVE: Prothrombotic genetic variants associated with arterial disease probably affect arterial thrombus formation but may also promote atherosclerosis. We hypothesized that specific prothrombotic variants lead to advanced atherosclerosis in patients with cerebral ischemia of arterial origin. METHODS AND RESULTS: We included 689 patients with nondisabling cerebral ischemia of arterial origin. Twenty-two variants in 14 genes were genotyped. None of the variants was associated with carotid intima-media thickness or younger age at the occurrence of cerebral ischemia...
May 2009: Atherosclerosis
Tetsuro Yoshida, Kazuhiro Yajima, Takeshi Hibino, Kimihiko Kato, Hitoshi Matsuo, Tomonori Segawa, Sachiro Watanabe, Mitsutoshi Oguri, Kiyoshi Yokoi, Yoshinori Nozawa, Genjiro Kimura, Yoshiji Yamada
Hyperlipidemia or dyslipidemia is one of the most important risk factors for coronary heart disease. The purpose of the present study was to identify gene polymorphisms for assessment of the genetic risk for myocardial infarction (MI) in individuals with low or high serum concentrations of high- density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, or triglyceride (TG), thereby contributing to the personalized prevention of MI in such individuals. The study population comprised 2682 unrelated Japanese individuals (1796 men, 886 women), including 1113 subjects (869 men, 244 women) with MI and 1569 controls (927 men, 642 women)...
October 2007: International Journal of Molecular Medicine
Nauder Faraday, Elizabeth A Martinez, Robert B Scharpf, Laura Kasch-Semenza, Todd Dorman, Peter J Pronovost, Bruce Perler, Gary Gerstenblith, Paul F Bray, Lee A Fleisher
BACKGROUND: Current perioperative cardiac risk assessment tools use historic and surgical factors to stratify patient risk. Polymorphisms in platelet glycoprotein (GP) IIIa and GPIbalpha are associated with myocardial ischemic risk in nonsurgical settings, but their relation to perioperative ischemia is unclear. The authors hypothesized that platelet genotype would be an independent predictor of postoperative myocardial ischemia and would improve risk assessment when added to clinical factors...
December 2004: Anesthesiology
A Hillmann, D C Shields, D J Fitzgerald, D Kenny
The platelet glycoprotein lb-IX complex is critical in platelet adhesion under conditions of high shear stress. Three genetic polymorphisms in the GPlbalpha subunit have been variably associated with thrombotic disorders. Women with serious obstetrical complications have an increased incidence of polymorphisms in other coagulation factors predisposing them alpha to thrombosis. Three GPlb variants were genotyped in 271 women in an Irish primigravid population, 258 with recorded outcomes, and in 22 patients with recurrent thrombosis and 15 patients with recurrent fetal loss...
May 2000: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Keiko Ishii, Mitsuru Murata, Shuji Oguchi, Eiko Takeshita, Daisuke Ito, Norio Tanahashi, Yasuo Fukuuchi, Ikuo Saitou, Yasuo Ikeda, Kiyoaki Watanabe
Accumulating evidence suggests that several polymorphisms in factors regulating blood coagulation, platelet function, and lipid metabolism are relevant for susceptibility to ischemic cerebrovascular diseases (CVD). The present study analyzed 15 genetic polymorphisms possibly associated with atherosclerosis and thrombosis in a case-control study involving a total of 200 genetically unrelated Japanese patients with ischemic CVD (mean age 58.3 +/- 7.6 y) and 281 age- and gender-matched control subjects (59.0 +/- 4...
January 2004: Rinsho Byori. the Japanese Journal of Clinical Pathology
Hans Ulrichts, Karen Vanhoorelbeke, Sandra Cauwenberghs, Stephan Vauterin, Hartmut Kroll, Sentot Santoso, Hans Deckmyn
OBJECTIVE: Glycoprotein (GP) Ibalpha is the functionally dominant subunit of the platelet GPIb-IX-V receptor complex. The N-terminal domain of the GPIbalpha chain contains binding sites for alpha-thrombin and von Willebrand factor (VWF). The human platelet alloantigen (HPA)-2 polymorphism of the GPIbalpha gene is associated with a C/T transition at nucleotide 1018, resulting in a Thr/Met dimorphism at residue 145 of GPIbalpha. To study the structural and functional effects of this dimorphism, N-terminal fragments (AA1-289) of the HPA-2a and HPA-2b alloform of GPIbalpha expressed in CHO cells were used...
July 1, 2003: Arteriosclerosis, Thrombosis, and Vascular Biology
A P Reiner, D S Siscovick, F R Rosendaal
Over the past several years, platelet glycoprotein gene polymorphisms have received increasing attention as possible inherited determinants of prothrombotic tendency. However, their role in genetic susceptibility to thrombotic disease remains controversial. The glycoprotein IIIa Leu33Pro amino acid substitution appears to be associated with a subtle effect on platelet thrombogenicity in vitro, but is not a major risk factor for arterial thrombotic disease among the general population. Evidence suggests that the glycoprotein IIIa Pro33 allele may be associated with increased risk of thrombotic events following coronary re-vascularization and possibly among younger subjects with atherosclerosis...
September 2001: Reviews in Clinical and Experimental Hematology
S Simsek, P M Bleeker, C E van der Schoot, A E von dem Borne
The human platelet alloantigen HPA-2(Koa/Kob) system is involved in two clinical syndromes, neonatal alloimmune thrombocytopenia and platelet transfusion refractoriness. We have previously described that the human platelet alloantigens HPA-2a(Kob) and HPA-2b(Koa), are caused by a Thr145Met amino acid polymorphism in the N-terminal globular domain of the human platelet glycoprotein (GP) Ib alpha. In the present study the question was addressed as to whether a genetic association exists between this Thr145Met polymorphism and the recently described variable number of tandem repeat (VNTR) polymorphism in GP Ib alpha...
November 1994: Thrombosis and Haemostasis
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