keyword
MENU ▼
Read by QxMD icon Read
search

Redox signaling

keyword
https://www.readbyqxmd.com/read/28918565/forward-genetic-screens-identify-a-role-for-the-mitochondrial-her2-in-e-2-hexenal-responsiveness
#1
Alessandra Scala, Rossana Mirabella, Joachim Goedhart, Michel de Vries, Michel A Haring, Robert C Schuurink
This work adds a new player, HER2, downstream of the perception of E-2-hexenal, a green leaf volatile, and shows that E-2-hexenal specifically changes the redox status of the mitochondria. It is widely accepted that plants produce and respond to green leaf volatiles (GLVs), but the molecular components involved in transducing their perception are largely unknown. The GLV E-2-hexenal inhibits root elongation in seedlings and, using this phenotype, we isolated E-2-hexenal response (her) Arabidopsis thaliana mutants...
September 16, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28917761/graphene-nanoribbon-fept-bimetallic-nanoparticles-uric-acid-as-a-novel-magnetic-sensing-layer-of-screen-printed-electrode-for-sensitive-determination-of-ampyra
#2
Pegah Hashemi, Hasan Bagheri, Abbas Afkhami, Salimeh Amidi, Tayyebeh Madrakian
A novel electrochemical sensor for sensitive determination of ampyra (Am) based on graphene nanoribbons modified by iron-platinum bimetallic nanoparticles and uric acid (SPCE/FePtGNR/UA) dropped on the screen-printed carbon electrode (SPCE) surface and magnetically captured onto an SPCE working electrode surface is reported in the present work. The modified nanocomposite and sensing layer was characterized by different techniques, including cyclic voltammetry (CV), linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray powdered diffraction (XRD)...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916474/nox4-regulates-the-enos-uncoupling-process-in-aging-endothelial-cells
#3
Hwa-Young Lee, Hyung-Ryong Kim, Han-Jung Chae
ROS and its associated signaling contribute to vascular aging-associated endothelial disturbance. Since the non-effective endothelial nitric oxide synthase (eNOS) coupling status is related to vascular aging-related phenotypes, eNOS coupled/uncoupled system signaling was studied in human umbilical vein endothelial cells (HUVEC). Nitric oxide (NO) and eNOS Ser1177 were significantly decreased, whereas O2(-) (superoxide anion radical) increased with passage number. In aging cells, NADPH oxidase 4 (Nox4), one of the main superoxide generating enzymes, and its associated protein disulfide isomerase (PDI) chaperone were highly activated, and the resultant ER redox imbalance leads to disturbance of protein folding capability, namely endoplasmic reticulum (ER) stress, ultimately inducing dissociation between HSP90 and IRE-1α or PERK, decreasing HSP90 stability and dissociating the binding of eNOS from the HSP90 and leading to eNOS uncoupling...
September 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28915945/potentiometric-sensor-for-non-invasive-lactate-determination-in-human-sweat
#4
Massimo Onor, Stefano Gufoni, Tommaso Lomonaco, Silvia Ghimenti, Pietro Salvo, Fiodor Sorrentino, Emilia Bramanti
The present work describes a non invasive lactate sensing in sweat during workout. The sensing system is based on a non-equilibrium potentiometric measure performed using disposable, chemically modified, screen printed carbon electrodes (SPCEs) that can be wetted with sweat during the exercise. The potentiometric signal, which is proportional to lactate concentration in sweat, is produced by a redox reaction activated by UV radiation, as opposed to the enzymatic reaction employed in traditional, blood-based measuring devices...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28914782/the-future-challenge-of-reactive-oxygen-species-ros-in-hypertension-from-bench-to-bed-side
#5
REVIEW
Gabriele Togliatto, Giusy Lombardo, Maria Felice Brizzi
Reactive oxygen species (ROS) act as signaling molecules that control physiological processes, including cell adaptation to stress. Redox signaling via ROS has quite recently become the focus of much attention in numerous pathological contexts, including neurodegenerative diseases, kidney and cardiovascular disease. Imbalance in ROS formation and degradation has also been implicated in essential hypertension. Essential hypertension is characterized by multiple genetic and environmental factors which do not completely explain its associated risk factors...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28914766/development-of-a-sensitive-electrochemical-enzymatic-reaction-based-cholesterol-biosensor-using-nano-sized-carbon-interdigitated-electrodes-decorated-with-gold-nanoparticles
#6
Deepti Sharma, Jongmin Lee, Junyoung Seo, Heungjoo Shin
We developed a versatile and highly sensitive biosensor platform. The platform is based on electrochemical-enzymatic redox cycling induced by selective enzyme immobilization on nano-sized carbon interdigitated electrodes (IDEs) decorated with gold nanoparticles (AuNPs). Without resorting to sophisticated nanofabrication technologies, we used batch wafer-level carbon microelectromechanical systems (C-MEMS) processes to fabricate 3D carbon IDEs reproducibly, simply, and cost effectively. In addition, AuNPs were selectively electrodeposited on specific carbon nanoelectrodes; the high surface-to-volume ratio and fast electron transfer ability of AuNPs enhanced the electrochemical signal across these carbon IDEs...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28912786/co-infection-of-sweet-orange-with-severe-and-mild-strains-of-citrus-tristeza-virus-is-overwhelmingly-dominated-by-the-severe-strain-on-both-the-transcriptional-and-biological-levels
#7
Shimin Fu, Jonathan Shao, Changyong Zhou, John S Hartung
Citrus tristeza is one of the most destructive citrus diseases and is caused by the phloem-restricted Closterovirus, Citrus tristeza virus. Mild strain CTV-B2 does not cause obvious symptoms on indicators whereas severe strain CTV-B6 causes symptoms, including stem pitting, cupping, yellowing, and stiffening of leaves, and vein corking. Our laboratory has previously characterized changes in transcription in sweet orange separately infected with CTV-B2 and CTV-B6. In the present study, transcriptome analysis of Citrus sinensis in response to double infection by CTV-B2 and CTV-B6 was carried out...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28912256/mitochondrial-capacity-oxidative-damage-and-hypoxia-gene-expression-are-associated-with-age-related-division-of-labor-in-honey-bee-apis-mellifera-l-workers
#8
Mário S Cervoni, Carlos A M Cardoso-Júnior, Giovana Craveiro, Anderson de O Souza, Luciane C Alberici, Klaus Hartfelder
During adult life, honeybee workers undergo a succession of behavioral states. Nurses bees perform tasks inside the nest, and when they are about 2-3 weeks old they initiate foraging. This switch is associated with alterations in diet, and with the levels of juvenile hormone and vitellogenin circulating in hemolymph. Less clear is whether this behavioral maturation involves major changes at the cellular level, such as mitochondrial activity and the redox environment in the head, thorax and abdomen. Using high-resolution respirometry, biochemical assays and RT-qPCR, we evaluated the association of these parameters with this behavioral change...
September 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28912082/mapk-signalling-pathway-in-cancers-olive-products-as-cancer-preventive-and-therapeutic-agents
#9
REVIEW
Ilaria Peluso, Nagendra Sastry Yarla, Roberto Ambra, Gianni Pastore, George Perry
The mitogen-activated protein kinases (MAPKs) are fundamental in inflammation and cancer control, through the crosstalk between the redox regulated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kB (NFκB) gene expression. MAPKs regulate various cellular activities involved in cancer progression, including proliferation, apoptosis and immune escape and blockade of upstream kinases is a current therapeutic strategy. However, these therapies are associated with some adverse effects and with the paradoxical activation of the MAPKs pathway...
September 11, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28910859/investigation-of-the-effects-of-storage-and-freezing-on-mixes-of-heavy-labeled-metabolite-and-amino-acid-standards
#10
Rachel Culp-Hill, Julie A Reisz, Kirk C Hansen, Angelo D'Alessandro
RATIONALE: High-throughput metabolomics has now made it possible for small/medium-sized laboratories to analyze thousands of samples/year from the most diverse biological matrices including biofluids, cell and tissue extracts. In large scale metabolomics studies, stable isotope-labeled standards are increasingly used to normalize for matrix effects and control for technical reproducibility (e.g. extraction efficiency, chromatographic retention times and mass spectrometry signal stability)...
September 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28904402/power-frequency-magnetic-field-promotes-a-more-malignant-phenotype-in-neuroblastoma-cells-via-redox-related-mechanisms
#11
S Falone, S Santini, V Cordone, P Cesare, A Bonfigli, M Grannonico, G Di Emidio, C Tatone, M Cacchio, F Amicarelli
In accordance with the classification of the International Agency for Research on Cancer, extremely low frequency magnetic fields (ELF-MF) are suspected to promote malignant progression by providing survival advantage to cancer cells through the activation of critical cytoprotective pathways. Among these, the major antioxidative and detoxification defence systems might be targeted by ELF-MF by conferring cells significant resistance against clinically-relevant cytotoxic agents. We investigated whether the hyperproliferation that is induced in SH-SY5Y human neuroblastoma cells by a 50 Hz, 1 mT ELF magnetic field was supported by improved defence towards reactive oxygen species (ROS) and xenobiotics, as well as by reduced vulnerability against both H2O2 and anti-tumor ROS-generating drug doxorubicin...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903064/isolation-and-characterization-of-peroxiredoxin-1-gene-of-dunaliella-salina
#12
Fanghua Gong, Jing Wang, Jie Li
Peroxiredoxin 1 (Prdx1) is a ubiquitously expressed protein in eukaryotic cells, and plays an important role in cell proliferation, differentiation, apoptosis, and redox signaling. Although Prdx1 has been better studied in yeasts and humans, only few Prdx1 genes have been cloned in green algae. The microalga Dunaliella salina (D. salina) is a model for the study of a variety of human cilia-related diseases. In this study, a suppression subtractive hybridization cDNA library of D. salina was constructed, and 6 flagellum-associated genes including D...
September 10, 2017: Gene
https://www.readbyqxmd.com/read/28902851/redox-mediated-quorum-sensing-in-plants
#13
Alexandra W Fuller, Phoebe Young, B Daniel Pierce, Jamie Kitson-Finuff, Purvi Jain, Karl Schneider, Stephen Lazar, Olga Taran, Andrew G Palmer, David G Lynn
The rhizosphere, the narrow zone of soil around plant roots, is a complex network of interactions between plants, bacteria, and a variety of other organisms. The absolute dependence on host-derived signals, or xenognosins, to regulate critical developmental checkpoints for host commitment in the obligate parasitic plants provides a window into the rhizosphere's chemical dynamics. These sessile intruders use H2O2 in a process known as semagenesis to chemically modify the mature root surfaces of proximal host plants and generate p-benzoquinones (BQs)...
2017: PloS One
https://www.readbyqxmd.com/read/28900911/the-stim-orai-pathway-regulation-of-stim-and-orai-by-thiol-modifications
#14
Barbara A Niemeyer
Cysteines are among the least abundant amino acids found in proteins. Due to their unique nucleophilic thiol group, they are able to undergo a broad range of chemical modifications besides their known role in disulfide formation, such as S-sulfenylation (-SOH), S-sulfinylation (-SO(2)H), S-sufonylation (-SO(3)H), S-glutathionylation (-SSG), and S-sulfhydration (-SSH), among others. These posttranslational modifications can be irreversible and act as transitional modifiers or as reversible on-off switches for the function of proteins...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28900667/ammonium-trichloro-1-2-ethanediolato-o-o-tellurate-cures-experimental-visceral-leishmaniasis-by-redox-modulation-of-leishmania-donovani-trypanothione-reductase-and-inhibiting-host-integrin-linked-pi3k-akt-pathway
#15
Preeti Vishwakarma, Naveen Parmar, Pragya Chandrakar, Tanuj Sharma, Manoj Kathuria, Pramod K Agnihotri, Mohammad Imran Siddiqi, Kalyan Mitra, Susanta Kar
In an endeavor to search for affordable and safer therapeutics against debilitating visceral leishmaniasis, we examined antileishmanial potential of ammonium trichloro [1,2-ethanediolato-O,O']-tellurate (AS101); a tellurium based non toxic immunomodulator. AS101 showed significant in vitro efficacy against both Leishmania donovani promastigotes and amastigotes at sub-micromolar concentrations. AS101 could also completely eliminate organ parasite load from L. donovani infected Balb/c mice along with significant efficacy against infected hamsters (˃93% inhibition)...
September 12, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28899780/hydrogen-peroxide-production-is-affected-by-oxygen-levels-in-mammalian-cell-culture
#16
Lucas A Maddalena, Shehab M Selim, Joao Fonseca, Holt Messner, Shannon McGowan, Jeffrey A Stuart
Although oxygen levels in the extracellular space of most mammalian tissues are just a few percent, under standard cell culture conditions they are not regulated and are often substantially higher. Some cellular sources of reactive oxygen species, like NADPH oxidase 4, are sensitive to oxygen levels in the range between 'normal' physiological (typically 1-5%) and standard cell culture (up to 18%). Hydrogen peroxide in particular participates in signal transduction pathways via protein redox modifications, so the potential increase in its production under standard cell culture conditions is important to understand...
September 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28899716/from-birth-to-death-a-role-for-reactive-oxygen-species-in-neuronal-development
#17
REVIEW
Carlos Wilson, Ernesto Muñoz-Palma, Christian González-Billault
Historically, ROS have been considered toxic molecules, especially when their intracellular concentration reaches high values. However, physiological levels of ROS support crucial cellular processes, acting as second messengers able to regulate intrinsic signaling pathways. Specifically, both the central and peripheral nervous systems are especially susceptible to changes in the redox state, developing either a defense or adaptive response depending on the concentration, source and duration of the pro-oxidative stimuli...
September 9, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28895781/selective-nitration-of-psbo1-psbo2-and-psbp1-decreases-psii-oxygen-evolution-and-photochemical-efficiency-in-intact-leaves-of-arabidopsis
#18
Misa Takahashi, Jun Shigeto, Atsushi Sakamoto, Hiromichi Morikawa
Exposure of intact Arabidopsis leaves to 40 ppm nitrogen dioxide (NO2) in light resulted almost exclusively in nitration of PsbO1, PsbO2, and PsbP1 of photosystem II (PSII), with minor nitration of four non-PS II proteins, including peroxiredoxin II E, as reported previously. Our previous findings that light-triggered selective nitration of PsbO1 decreased oxygen evolution and that inhibition of photoelectric electron transport inhibited nitration of PsbO1 implied that the nitratable tyrosine residue of PsbO1 is redox-active...
September 12, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28894510/antioxidant-and-anti-inflammatory-effects-of-shungite-against-ultraviolet-b-irradiation-induced-skin-damage-in-hairless-mice
#19
Ma Easter Joy Sajo, Cheol-Su Kim, Soo-Ki Kim, Kwang Yong Shim, Tae-Young Kang, Kyu-Jae Lee
As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-) induced skin damage by investigating the physiological skin parameters, immune-redox profiling, and oxidative stress molecular signaling. Toward this, mice were UVB-irradiated with 0.75 mW/cm(2) for two consecutive days...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28893604/redox-signalling-in-development-and-regeneration
#20
EDITORIAL
Sophie Vriz
No abstract text is available yet for this article.
September 8, 2017: Seminars in Cell & Developmental Biology
keyword
keyword
113022
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"