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Redox signaling

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https://www.readbyqxmd.com/read/28737778/intense-redox-driven-chiroptical-switching-with-a-580-mv-hysteresis-actuated-through-reversible-dimerization-of-an-azoniahelicene
#1
Jochen R Brandt, Lubomír Pospíšil, Lucie Bednárová, Rosenildo Correa da Costa, Andrew J P White, Tadashi Mori, Filip Teplý, Matthew J Fuchter
Electrochemical reduction of an azoniahelicene affords a dimer, accompanied by a strong change in the electronic circular dichroism. The fast dimerisation event leads to a >500 mV shift of the oxidation potential, affording a large area of bistability, where the chiroptical signal only depends on the redox history.
July 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28736529/detection-of-ros-induced-proteomic-signatures-by-mass-spectrometry
#2
REVIEW
Brian McDonagh
Reversible and irreversible post-translational modifications (PTMs) induced by endogenously generated reactive oxygen species (ROS) in regulatory enzymes and proteins plays an essential role in cellular signaling. Almost all cellular processes including metabolism, transcription, translation and degradation have been identified as containing redox regulated proteins. Specific redox modifications of key amino acids generated by ROS offers a dynamic and versatile means to rapidly alter the activity or functional structure of proteins in response to biochemical, environmental, genetic and pathological perturbations...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28736239/%C3%AE-trcp1-is-a-vacillatory-regulator-of-wnt-signaling
#3
Marcus John Long, Hong-Yu Lin, Saba Parvez, Yi Zhao, Jesse Richard Poganik, Paul Huang, Yimon Aye
Simultaneous hyperactivation of Wnt and antioxidant response (AR) are often observed during oncogenesis. However, it remains unclear how the β-catenin-driven Wnt and the Nrf2-driven AR mutually regulate each other. The situation is compounded because many players in these two pathways are redox sensors, rendering bolus redox signal-dosing methods uninformative. Herein we examine the ramifications of single-protein target-specific AR upregulation in various knockdown lines. Our data document that Nrf2/AR strongly inhibits β-catenin/Wnt...
July 10, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28735399/probing-posttranslational-redox-modifications
#4
Patrick Treffon, Michael Liebthal, Wilena Telman, Karl-Josef Dietz
Reactive molecular species (RMS) can damage DNA, lipids, and proteins but as signaling molecules they also affect the regulatory state of the cell. RMS consist of reactive oxygen (ROS), nitrogen (RNS), and carbonyl species (RCS). Besides their potentially destructive nature, RMS are able to modify proteins at the posttranslational level, resulting in regulation of structure, activity, interaction as well as localization. This chapter addresses methods to analyze and quantify posttranslational redox modifications in vitro and ex vivo, such as sulfenic acid generation of cysteine residues and oxidative carbonylation of proteins...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735389/the-fundamental-role-of-reactive-oxygen-species-in-plant-stress-response
#5
Michael Liebthal, Karl-Josef Dietz
Chemical, physical, and biotic factors continuously vary in the natural environment. Such parameters are considered as stressors if the magnitude of their change exceeds the current acclimation norm of the plant. Activation of genetic programs allows for conditional expansion of the acclimation norm and depends on specific sensing mechanisms, intracellular communication, and regulation. The redox and reactive oxygen species (ROS) network plays a fundamental role in directing the acclimation response. These highly reactive compounds like H2O2 are generated and scavenged under normal conditions and participate in realizing a basal acclimation level...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28733165/ros-related-redox-regulation-and-signaling-in-plants
#6
REVIEW
Graham Noctor, Jean-Philippe Reichheld, Christine H Foyer
As sessile oxygenic organisms with a plastic developmental programme, plants are uniquely positioned to exploit reactive oxygen species (ROS) as powerful signals. Plants harbor numerous ROS-generating pathways, and these oxidants and related redox-active compounds have become tightly embedded into plant function and development during the course of evolution. One dominant view of ROS-removing systems sees them as beneficial antioxidants battling to keep damaging ROS below dangerous levels. However, it is now established that ROS are a necessary part of subcellular and intercellular communication in plants and that some of their signaling functions require ROS-metabolizing systems...
July 18, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28729810/the-interplay-of-electrode-and-bio-materials-in-a-redox-cycling-based-clozapine-sensor
#7
Thomas E Winkler, Robert Dietrich, Eunkyoung Kim, Hadar Ben-Yoav, Deanna L Kelly, Gregory F Payne, Reza Ghodssi
We investigate gold, TiN, and platinum in combination with a chitosan-catechol-based redox-cycling system (RCS) for electrochemical detection of the antipsychotic clozapine. We have previously demonstrated the RCS for detection of clozapine in serum, but challenges remain regarding low signal-to-noise ratios. This can be mitigated by selection of electrode materials with beneficial surface morphologies and/or compositions. We employ cyclic voltammetry to assess the redox current generated by clozapine, and differentiate solely surface-area-based effects from clozapine-specific ones using a standard redox couple...
June 2017: Electrochemistry Communications
https://www.readbyqxmd.com/read/28729485/response-to-comments-on-the-4fe4s-cluster-of-human-dna-primase-functions-as-a-redox-switch-using-dna-charge-transport
#8
Elizabeth O'Brien, Marilyn E Holt, Matthew K Thompson, Lauren E Salay, Aaron C Ehlinger, Walter J Chazin, Jacqueline K Barton
Baranovskiy et al and Pellegrini argue that, based on structural data, the path for charge transfer through the [4Fe4S] domain of primase is not feasible. Our manuscript presents electrochemical data directly showing charge transport through DNA to the [4Fe4S] cluster of a primase p58C construct and a reversible switch in the DNA-bound signal with oxidation/reduction, which is inhibited by mutation of three tyrosine residues. Although the dispositions of tyrosines differ in different constructs, all are within range for microsecond electron transfer...
July 21, 2017: Science
https://www.readbyqxmd.com/read/28729399/decitabine-priming-enhances-mucin-1-inhibition-mediated-disruption-of-redox-homeostasis-in-cutaneous-t-cell-lymphoma
#9
Salvia Jain, Abigail Washington, Rebecca Karp Leaf, Parul Bhargava, Rachael A Clark, Thomas S Kupper, Dina Stroopinsky, Athalia Pyzer, Leandra Cole, Myrna Nahas, Arie Apel, Jacalyn Rosenblatt, Jon Arnason, Donald Kufe, David Avigan
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous neoplasm and patients with relapsed/refractory disease exhibit resistance to standard therapies. We have previously demonstrated that the MUC1-C oncoprotein plays a critical role in protection from oxidative stress in CTCL cells. Targeting of MUC1-C with a pharmacologic inhibitor, GO-203, was associated with apoptosis in CTCL. However, disease responses were incomplete underscoring the need for combinatorial strategies that could exploit the vulnerability of CTCL cells to oxidative signals...
July 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28728925/potential-anti-cancer-activity-of-7-o-pentyl-quercetin-efficient-membrane-targeted-kinase-inhibition-and-pro-oxidant-effect
#10
Nicola Sassi, Andrea Mattarei, Virginia Espina, Lance Liotta, Mario Zoratti, Cristina Paradisi, Lucia Biasutto
Quercetin is a redox-active plant-derived flavonoid with potential anticancer effects, stemming largely from its interaction with a number of proteins, and in particular from inhibition of pro-life kinases. To improve efficacy, we reasoned that a local increase in concentration of the compound at the level of cell membranes would result in a more efficient interaction with membrane-associated signaling kinases. We report here the synthesis of all five isomeric quercetin derivatives in which an n-pentyl group was linked via an ether bond to each hydroxyl of the flavonoid kernel...
July 17, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28726269/previous-physical-exercise-alters-hepatic-profile-of-oxidative-inflammatory-status-and-limits-the-secondary-brain-damage-induced-by-severe-tbi-in-rats
#11
Mauro Robson Torres de Castro, Ana Paula de Oliveira Ferreira, Guilherme Lago Busanello, Luís Roberto Hart da Silva, Mauro Eduardo Porto da Silveira Junior, Fernando Fiorin, Gabriela Arrifano, Maria Elena Crespo López, Rômulo Pillon Barcelos, María J Cuevas, Guilherme Bresciani, Javier González-Gallego, Michele Rechia Fighera, Luiz Fernando Freire Royes
Although systemic responses have been described after traumatic brain injury (TBI), little is known regarding potential interactions between brain and peripheral organs after neuronal injury. In this sense, we decided to investigate whether peripheral oxidative/inflammatory response contributes to the neuronal dysfunction after TBI as well as prophylactic role of exercise training. Animals were submitted to fluid percussion injury (FPI) after 6 weeks of swimming training. Previous exercise training increased mRNA expression of X receptor alpha (LXR-α), ATP-binding cassette transporter (ABCA1), and decreased inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6 expression per se in liver...
July 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28725231/chloroplast-redox-status-modulates-genome-wide-plant-responses-during-the-non-host-interaction-of-tobacco-with-the-hemibiotrophic-bacterium-xanthomonas-campestris-pv-vesicatoria
#12
Juan J Pierella Karlusich, Matias D Zurbriggen, Fahimeh Shahinnia, Sophia Sonnewald, Uwe Sonnewald, Seyed A Hosseini, Mohammad-Reza Hajirezaei, Néstor Carrillo
Non-host resistance is the most ample and durable form of plant resistance against pathogen infection. It includes induction of defense-associated genes, massive metabolic reprogramming, and in many instances, a form of localized cell death (LCD) at the site of infection, purportedly designed to limit the spread of biotrophic and hemibiotrophic microorganisms. Reactive oxygen species (ROS) have been proposed to act as signals for LCD orchestration. They are produced in various cellular compartments including chloroplasts, mitochondria and apoplast...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28724541/stim1-and-stim2-cooperatively-regulate-mouse-neutrophil-store-operated-calcium-entry-and-cytokine-production
#13
Regina A Clemens, Joshua Chong, Derayvia Grimes, Yongmei Hu, Clifford A Lowell
Neutrophils are key effector cells of the innate immune system. Calcium-dependent signaling pathways initiated by store-operated calcium entry (SOCE) are known to regulate neutrophil activation, however the precise mechanism of this process remains unclear. STIM1 and STIM2 are calcium sensing molecules that link calcium depletion of the endoplasmic reticulum with opening of plasma membrane calcium channels. While a role for STIM1 in neutrophil SOCE and activation has been established, the function of STIM2 is unknown...
July 19, 2017: Blood
https://www.readbyqxmd.com/read/28724388/o-glcnac-regulation-of-autophagy-and-%C3%AE-synuclein-homeostasis-implications-for-parkinson-s-disease
#14
Willayat Y Wani, Xiaosen Ouyang, Gloria A Benavides, Matthew Redmann, Stacey S Cofield, John J Shacka, John C Chatham, Victor Darley-Usmar, Jianhua Zhang
Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. One of the most common neurodegenerative diseases that exhibit aberrant redox signaling, metabolism and stress response is Parkinson's disease, suggesting a potential role for O-GlcNAcylation in its pathology. To determine whether abnormal O-GlcNAcylation occurs in Parkinson's disease, we analyzed lysates from the postmortem temporal cortex of Parkinson's disease patients and compared them to age matched controls and found increased protein O-GlcNAcylation levels...
July 19, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28723199/rational-design-of-a-stimuli-responsive-polymer-electrode-interface-coupled-with-in-vivo-microdialysis-for-measurement-of-sialic-acid-in-live-mouse-brain-in-alzheimer-s-disease
#15
Shushu Ding, Sumei Cao, Yingzi Liu, Ying Lian, Anwei Zhu, Guoyue Shi
Sensitive and selective monitoring of sialic acid (SA) in cerebral nervous system is of great importance for studying the role that SA plays in the pathological process of Alzheimer's disease (AD). In this work, we first reported an electrochemical biosensor based on a novel stimuli-responsive copolymer for selective and sensitive detection of SA in mouse brain. Notably, through synergetic hydrogen-bonding interactions, the copolymer could translate the recognition of SA into their conformational transition and wettability switch, which facilitated the access and enrichment of redox labels and targets to the electrode surface, thus significantly improving the detection sensitivity with the detection limit down to 0...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28715969/hypoxia-and-redox-signaling-on-extracellular-matrix-remodeling-from-the-mechanisms-to-the-pathological-implications
#16
David Labrousse-Arias, Antonio Martínez-Ruiz, Maria J Calzada
SIGNIFICANCE: The extracellular matrix (ECM) is an essential modulator of cell behavior that influences tissue organization. It has a strong relevance in homeostasis and translational implications for human disease. In addition to ECM structural proteins, matricellular proteins are important regulators of the ECM that are involved in a myriad of different pathologies. Recent Advances: Biochemical studies, animal models and study of human diseases have contributed to the knowledge of molecular mechanisms involved in the remodeling of the ECM, both in homeostasis and disease...
July 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28715792/smartphone-based-cyclic-voltammetry-system-with-graphene-modified-screen-printed-electrodes-for-glucose-detection
#17
Daizong Ji, Lei Liu, Shuang Li, Chen Chen, Yanli Lu, Jiajia Wu, Qingjun Liu
Smartphone-based electrochemical devices have such advantages as the low price, miniaturization, and obtaining the real-time data. As a popular electrochemical method, cyclic voltammetry (CV) has shown its great practicability for quantitative detection and electrodes modification. In this study, a smartphone-based CV system with a simple method of electrode modification was constructed to perform electrochemical detections. The system was composed of these main portions: modified electrodes, portable electrochemical detector and smartphone...
July 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28715730/redox-regulation-of-proteasome-function
#18
Maria Lefaki, Nikoletta Papaevgeniou, Niki Chondrogianni
Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades, as well as modulators of biochemical pathways. Proteostasis is highly affected by the various levels of intracellular and extracellular free radicals with either mild or severe outcomes. As part of the proteostatic network, the proteasome system is equally affected by redox alterations...
July 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28714308/supersensitive-oxidation-responsive-biodegradable-peg-hydrogels-for-glucose-triggered-insulin-delivery
#19
Mei Zhang, Cheng-Cheng Song, Fu-Sheng Du, Zi-Chen Li
Reactive oxygen species (ROS)-responsive polymers and hydrogels represent an emerging family of intelligent materials owing to the key functions of ROS in physiological processes or pathological diseases. Nonetheless, the weaknesses such as low sensitivity, slow response, instability, and low mechanical strength are associated with the limited ROS-responsive polymeric or supramolecular hydrogels. In this study, a novel type of oxidation-responsive degradable hydrogels was fabricated by the redox-initiated radical polymerization of a 4-arm-poly(ethylene glycol) (PEG) acrylic macromonomer that possesses a H2O2-cleavable phenylboronic acid linker in each of the arms...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28713491/mulberry-anthocyanin-extract-ameliorates-oxidative-damage-in-hepg2-cells-and-prolongs-the-lifespan-of-caenorhabditis-elegans-through-mapk-and-nrf2-pathways
#20
Fujie Yan, Yushu Chen, Ramila Azat, Xiaodong Zheng
Mulberry anthocyanins possess many pharmacological effects including liver protection, anti-inflammation, and anticancer. The aim of this study was to evaluate whether mulberry anthocyanin extract (MAE) exerts beneficial effects against oxidative stress damage in HepG2 cells and Caenorhabditis elegans. In vitro, MAE prevented cytotoxicity, increased glucose consumption and uptake, and eliminated excessive intracellular free radicals in H2O2-induced cells. Moreover, MAE pretreatment maintained Nrf2, HO-1, and p38 MAPK stimulation and abolished upregulation of p-JNK, FOXO1, and PGC-1α that were involved in oxidative stress and insulin signalling modulation...
2017: Oxidative Medicine and Cellular Longevity
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