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https://www.readbyqxmd.com/read/27618111/protandim-protects-oligodendrocytes-against-an-oxidative-insult
#1
Jamie L Lim, Susanne M A van der Pol, Wia Baron, Joe M McCord, Helga E de Vries, Jack van Horssen
Oligodendrocyte damage and loss are key features of multiple sclerosis (MS) pathology. Oligodendrocytes appear to be particularly vulnerable to reactive oxygen species (ROS) and cytokines, such as tumor necrosis factor-α (TNF), which induce cell death and prevent the differentiation of oligodendrocyte progenitor cells (OPCs). Here, we investigated the efficacy of sulforaphane (SFN), monomethyl fumarate (MMF) and Protandim to induce Nrf2-regulated antioxidant enzyme expression, and protect oligodendrocytes against ROS-induced cell death and ROS-and TNF-mediated inhibition of OPC differentiation...
September 7, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27513339/the-effect-of-protandim%C3%A2-supplementation-on-athletic-performance-and-oxidative-blood-markers-in-runners
#2
Seteena L Ueberschlag, James R Seay, Alexandra H Roberts, Pamela C DeSpirito, Jeremy M Stith, Rodney J Folz, Kathleen A Carter, Edward P Weiss, Gerald S Zavorsky
UNLABELLED: The purpose of this study determined if oral supplementation of Protandim® (a nutraceutical) for 90 days improved 5-km running performance and reduced serum thiobarbituric acid-reacting substances (TBARS) at rest, an indicator of oxidative stress. Secondary objectives were to measure whole blood superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPX), at rest and 10 minutes after completion of the race before and after supplementation as well as quality of life...
2016: PloS One
https://www.readbyqxmd.com/read/27463229/elucidating-the-role-of-protandim-and-6-gingerol-in-protection-against-osteoarthritis
#3
Jamilah Abusarah, Houda Abir Benabdoun, Qin Shi, Bertrand Lussier, Johanne Martel-Pelletier, Michel Malo, Julio C Fernandes, Fátima Pereira de Souza, Hassan Fahmi, Mohamed Benderdour
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. In this study, we evaluated the effects of these products on the expression of different factors involved in osteoarthritis (OA) process. Human OA chondrocytes were treated with 1 ng/ml IL-1β in the presence or absence of protandim (0-10 μg/ml) or 6-gingerol (0-10 μM). OA was induced surgically in mice by destabilization of the medial meniscus (DMM)...
July 27, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27312235/longer-lifespan-in-male-mice-treated-with-a-weakly-estrogenic-agonist-an-antioxidant-an-%C3%AE-glucosidase-inhibitor-or-a-nrf2-inducer
#4
Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming, Martin A Javors, João Pedro de Magalhães, Paul Anthony Martinez, Joe M McCord, Benjamin F Miller, Michael Müller, James F Nelson, Juliet Ndukum, G Ed Rainger, Arlan Richardson, David M Sabatini, Adam B Salmon, James W Simpkins, Wilma T Steegenga, Nancy L Nadon, David E Harrison
The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each compound is tested in parallel at three sites, and all results are published. We report the effects of lifelong treatment of mice with four agents not previously tested: Protandim, fish oil, ursodeoxycholic acid (UDCA) and metformin - the latter with and without rapamycin, and two drugs previously examined: 17-α-estradiol and nordihydroguaiaretic acid (NDGA), at doses greater and less than used previously...
October 2016: Aging Cell
https://www.readbyqxmd.com/read/26682723/prestin-dependence-of-outer-hair-cell-survival-and-partial-rescue-of-outer-hair-cell-loss-in-prestinv499g-y501h-knockin-mice
#5
Mary Ann Cheatham, Roxanne M Edge, Kazuaki Homma, Emily L Leserman, Peter Dallos, Jing Zheng
A knockin (KI) mouse expressing mutated prestinV499G/Y501H (499 prestin) was created to study cochlear amplification. Recordings from isolated outer hair cells (OHC) in this mutant showed vastly reduced electromotility and, as a consequence, reduced hearing sensitivity. Although 499 prestin OHCs were normal in stiffness and longer than OHCs lacking prestin, accelerated OHC death was unexpectedly observed relative to that documented in prestin knockout (KO) mice. These observations imply an additional role of prestin in OHC maintenance besides its known requirement for mammalian cochlear amplification...
2015: PloS One
https://www.readbyqxmd.com/read/23722164/nrf2-activation-a-potential-strategy-for-the-prevention-of-acute-mountain-sickness
#6
Christina Lisk, Joe McCord, Swapan Bose, Tim Sullivan, Zoe Loomis, Eva Nozik-Grayck, Thies Schroeder, Karyn Hamilton, David C Irwin
Reactive oxygen species (ROS) formed during acute high altitude exposure contribute to cerebral vascular leak and development of acute mountain sickness (AMS). Nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) is a transcription factor that regulates expression of greater than 90% of antioxidant genes, but prophylactic treatment with Nrf2 activators has not yet been tested as an AMS therapy. We hypothesized that prophylactic activation of the antioxidant genome with Nrf2 activators would attenuate high-altitude-induced ROS formation and cerebral vascular leak and that some drugs currently used to treat AMS symptoms have an additional trait of Nrf2 activation...
October 2013: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/23201694/upregulation-of-phase-ii-enzymes-through-phytochemical-activation-of-nrf2-protects-cardiomyocytes-against-oxidant-stress
#7
Danielle J Reuland, Shadi Khademi, Christopher J Castle, David C Irwin, Joe M McCord, Benjamin F Miller, Karyn L Hamilton
Increased production of reactive oxygen species has been implicated in the pathogenesis of cardiovascular disease (CVD), and enhanced endogenous antioxidants have been proposed as a mechanism for regulating redox balance. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcriptional regulator of phase II antioxidant enzymes, and activation of Nrf2 has been suggested to be an important step in attenuating oxidative stress associated with CVD. A well-defined combination of five widely studied medicinal plants derived from botanical sources (Bacopa monniera, Silybum marianum (milk thistle), Withania somnifera (Ashwagandha), Camellia sinensis (green tea), and Curcuma longa (turmeric)) has been shown to activate Nrf2 and induce phase II enzymes through the antioxidant response element...
March 2013: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/22870869/antioxidants-for-the-treatment-of-patients-with-severe-angioproliferative-pulmonary-hypertension
#8
REVIEW
Norbert F Voelkel, Harm J Bogaard, Aysar Al Husseini, Laszlo Farkas, Jose Gomez-Arroyo, Ramesh Natarajan
SIGNIFICANCE: Pathobiological mechanisms that contribute to pulmonary vasoconstriction, lung vascular remodeling, and the development of right heart failure include the generation of reactive oxygen and nitrogen species and the response of lung vascular and cardiac cells to these molecules. We review the information regarding oxidant stress balanced by antioxidant mechanisms and the role of oxidants and antioxidants in hypoxic pulmonary hypertension and their potential role in an animal model of severe pulmonary arterial hypertension (PAH)...
May 10, 2013: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/22685617/phytochemical-activation-of-nrf2-protects-human-coronary-artery-endothelial-cells-against-an-oxidative-challenge
#9
Elise L Donovan, Joe M McCord, Danielle J Reuland, Benjamin F Miller, Karyn L Hamilton
Activation of NF-E2-related factor 2 (Nrf2) is a potential therapeutic intervention against endothelial cell oxidative stress and associated vascular disease. We hypothesized that treatment with the phytochemicals in the patented dietary supplement Protandim would induce Nrf2 nuclear localization and phase II antioxidant enzyme protein in human coronary artery endothelial cells (HCAECs), protecting against an oxidant challenge in an Nrf2- dependent manner. Protandim treatment induced Nrf2 nuclear localization, and HO-1 (778% of control ± 82...
2012: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/22268125/protandim-does-not-influence-alveolar-epithelial-permeability-or-intrapulmonary-oxidative-stress-in-human-subjects-with-alcohol-use-disorders
#10
RANDOMIZED CONTROLLED TRIAL
Ellen L Burnham, Joe M McCord, Swapan Bose, Lou Ann S Brown, Robert House, Marc Moss, Jeanette Gaydos
Alcohol use disorders (AUDs), including alcohol abuse and dependence, have been linked to the development of acute lung injury (ALI). Prior clinical investigations suggested an association between AUDs and abnormal alveolar epithelial permeability mediated through pulmonary oxidative stress that may partially explain this relationship. We sought to determine if correcting pulmonary oxidative stress in the setting of AUDs would normalize alveolar epithelial permeability in a double-blinded, randomized, placebo-controlled trial of Protandim, a nutraceutical reported to enhance antioxidant activity...
April 1, 2012: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/22020111/oxidative-stress-in-health-and-disease-the-therapeutic-potential-of-nrf2-activation
#11
REVIEW
Brooks M Hybertson, Bifeng Gao, Swapan K Bose, Joe M McCord
For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. Our view of oxidative stress has been largely "superoxide-centric", as we focused on the pathological sources of this oxygen-derived free radical and the types of molecular havoc it can wreak, as well as on the protection provided by the antioxidant enzymes, especially the superoxide dismutases, catalases, and glutathione peroxidases...
August 2011: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/21603266/the-role-of-manganese-superoxide-dismutase-in-skin-cancer
#12
Delira Robbins, Yunfeng Zhao
Recent studies have shown that antioxidant enzyme expression and activity are drastically reduced in most human skin diseases, leading to propagation of oxidative stress and continuous disease progression. However, antioxidants, an endogenous defense system against reactive oxygen species (ROS), can be induced by exogenous sources, resulting in protective effects against associated oxidative injury. Many studies have shown that the induction of antioxidants is an effective strategy to combat various disease states...
2011: Enzyme Research
https://www.readbyqxmd.com/read/21167278/protandim-attenuates-intimal-hyperplasia-in-human-saphenous-veins-cultured-ex-vivo-via-a-catalase-dependent-pathway
#13
Binata Joddar, Rashmeet K Reen, Michael S Firstenberg, Saradhadevi Varadharaj, Joe M McCord, Jay L Zweier, Keith J Gooch
Human saphenous veins (HSVs) are widely used for bypass grafts despite their relatively low long-term patency. To evaluate the role of reactive oxygen species (ROS) signaling in intima hyperplasia (IH), an early stage pathology of vein-graft disease, and to explore the potential therapeutic effects of up-regulating endogenous antioxidant enzymes, we studied segments of HSV cultured ex vivo in an established ex vivo model of HSV IH. Results showed that HSV cultured ex vivo exhibit an ~3-fold increase in proliferation and ~3...
March 15, 2011: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/20740052/the-dietary-supplement-protandim-decreases-plasma-osteopontin-and-improves-markers-of-oxidative-stress-in-muscular-dystrophy-mdx-mice
#14
Muhammad Muddasir Qureshi, Warren C McClure, Nicole L Arevalo, Rick E Rabon, Benjamin Mohr, Swapan K Bose, Joe M McCord, Brian S Tseng
Therapeutic options for Duchenne muscular dystrophy (DMD), the most common and lethal neuromuscular disorder in children, remain elusive. Oxidative damage is implicated as a pertinent factor involved in its pathogenesis. Protandim((R)) is an over-the-counter supplement with the ability to induce antioxidant enzymes. In this study we investigated whether Protandim((R)) provided benefit using surrogate markers and functional measures in the dystrophin-deficient (mdx)mouse model of DMD. Male 3-week-old mdx mice were randomized into two treatment groups: control (receiving standard rodent chow) and Protandim((R))-supplemented standard rodent chow...
June 1, 2010: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/20689586/the-chemopreventive-effects-of-protandim-modulation-of-p53-mitochondrial-translocation-and-apoptosis-during-skin-carcinogenesis
#15
Delira Robbins, Xin Gu, Runhua Shi, Jianfeng Liu, Fei Wang, Jacqulyne Ponville, Joe M McCord, Yunfeng Zhao
Protandim, a well defined dietary combination of 5 well-established medicinal plants, is known to induce endogenous antioxidant enzymes, such as manganese superoxide dismutase (MnSOD). Our previous studies have shown through the induction of various antioxidant enzymes, products of oxidative damage can be decreased. In addition, we have shown that tumor multiplicity and incidence can be decreased through the dietary administration of Protandim in the two-stage skin carcinogenesis mouse model. It has been demonstrated that cell proliferation is accommodated by cell death during DMBA/TPA treatment in the two-stage skin carcinogenesis model...
2010: PloS One
https://www.readbyqxmd.com/read/19884466/chronic-pulmonary-artery-pressure-elevation-is-insufficient-to-explain-right-heart-failure
#16
Harm J Bogaard, Ramesh Natarajan, Scott C Henderson, Carlin S Long, Donatas Kraskauskas, Lisa Smithson, Ramzi Ockaili, Joe M McCord, Norbert F Voelkel
BACKGROUND: The most important determinant of longevity in pulmonary arterial hypertension is right ventricular (RV) function, but in contrast to experimental work elucidating the pathobiology of left ventricular failure, there is a paucity of data on the cellular and molecular mechanisms of RV failure. METHODS AND RESULTS: A mechanical animal model of chronic progressive RV pressure overload (pulmonary artery banding, not associated with structural alterations of the lung circulation) was compared with an established model of angioproliferative pulmonary hypertension associated with fatal RV failure...
November 17, 2009: Circulation
https://www.readbyqxmd.com/read/19384424/protandim-a-fundamentally-new-antioxidant-approach-in-chemoprevention-using-mouse-two-stage-skin-carcinogenesis-as-a-model
#17
Jianfeng Liu, Xin Gu, Delira Robbins, Guohong Li, Runhua Shi, Joe M McCord, Yunfeng Zhao
Oxidative stress is an important contributor to cancer development. Consistent with that, antioxidant enzymes have been demonstrated to suppress tumorigenesis when being elevated both in vitro and in vivo, making induction of these enzymes a more potent approach for cancer prevention. Protandim, a well-defined combination of widely studied medicinal plants, has been shown to induce superoxide dismutase (SOD) and catalase activities and reduce superoxide generation and lipid peroxidation in healthy human subjects...
2009: PloS One
https://www.readbyqxmd.com/read/19056485/synergistic-induction-of-heme-oxygenase-1-by-the-components-of-the-antioxidant-supplement-protandim
#18
Kalpana Velmurugan, Jawed Alam, Joe M McCord, Subbiah Pugazhenthi
Protandim is an antioxidant supplement that consists of five ingredients, namely, ashwagandha, bacopa extract, green tea extract, silymarin, and curcumin, each with known therapeutic properties. Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. A recent clinical study demonstrated the in vivo antioxidant effects of Protandim (S.K. Nelson et al., 2006, Free Radic. Biol. Med. 40, 341-347). The objective of the present study was to determine if the components of Protandim induce heme oxygenase-1 (HO-1) in a synergistic manner in cultured MIN6 cells, a mouse beta-cell line, and in SK-N-MC cells, a human neuroblastoma cell line...
February 1, 2009: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/16413416/the-induction-of-human-superoxide-dismutase-and-catalase-in-vivo-a-fundamentally-new-approach-to-antioxidant-therapy
#19
COMPARATIVE STUDY
Sally K Nelson, Swapan K Bose, Gary K Grunwald, Paul Myhill, Joe M McCord
A composition consisting of extracts of five widely studied medicinal plants (Protandim) was administered to healthy human subjects ranging in age from 20 to 78 years. Individual ingredients were selected on the basis of published findings of induction of superoxide dismutase (SOD) and/or catalase in rodents in vivo, combined with evidence of decreasing lipid peroxidation. Each ingredient was present at a dosage sufficiently low to avoid any accompanying unwanted pharmacological effects. Blood was analyzed before supplementation and after 30 and 120 days of supplementation (675 mg/day)...
January 15, 2006: Free Radical Biology & Medicine
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