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https://www.readbyqxmd.com/read/27898736/long-term-antiretroviral-treatment-adherence-in-hiv-infected-adolescents-and-adults-in-uganda-a-qualitative-study
#1
Seth C Inzaule, Raph L Hamers, Cissy Kityo, Tobias F Rinke de Wit, Maria Roura
BACKGROUND: Long-term success of HIV antiretroviral therapy requires near-perfect adherence, maintained throughout one's lifetime. However, perceptions towards ART and patterns of adherence may change during the life course. We assessed challenges to long-term adherence in adolescents and adults in three regional HIV treatment centers in Uganda. METHODS: We conducted 24 in-depth interviews and 2 focus group discussions with a total of 33 health-care providers and expert clients (HIV patients on long-term ART who assist with adherence support of fellow patients)...
2016: PloS One
https://www.readbyqxmd.com/read/27865674/does-anemia-affect-the-predictive-ability-of-bleeding-risk-scores-in-patients-with-acute-coronary-syndromes
#2
Alberto Garay, Albert Ariza-Solé, Francesc Formiga, Victoria Lorente, José C Sánchez-Salado, Joel Salazar-Mendiguchía, Gerard Roura, Guillem Muntané, Oriol Alegre, Lara Fuentes, Joan A Gómez-Hospital, Angel Cequier
INTRODUCTION AND OBJECTIVE: Anemia is a common comorbidity in patients with acute coronary syndromes (ACS), and is associated with higher risk for both bleeding and ischemic complications. We aimed to assess the predictive ability of bleeding risk scores (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines [CRUSADE], Mehran and Acute Coronary Treatment and Intervention Outcomes Network [ACTION]) in ACS patients with anemia...
November 16, 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27805725/laboratory-tests-for-diagnosing-and-monitoring-canine-leishmaniasis
#3
REVIEW
Saverio Paltrinieri, Luigi Gradoni, Xavier Roura, Andrea Zatelli, Eric Zini
Although several reviews on canine leishmaniasis have been published, none thoroughly described clinicopathologic abnormalities and their clinical usefulness. The aim of this review was to provide information concerning current diagnostic tests relevant for clinical pathologists and from a practical perspective. Specifically, in canine leishmaniasis, nonregenerative normocytic normochromic anemia, thrombocytopenia, or leukogram changes may be present. Clinical chemistry and urinalysis may indicate renal dysfunction (azotemia, decreased urine specific gravity, proteinuria) and an inflammatory/immune response (increased acute phase proteins [APP] or α2 - and/or γ-globulins)...
November 2, 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27704168/adverse-drug-events-in-patients-with-advanced-chronic-conditions-who-have-a-prognosis-of-limited-life-expectancy-at-hospital-admission
#4
Daniel Sevilla-Sanchez, Núria Molist-Brunet, Jordi Amblàs-Novellas, Pere Roura-Poch, Joan Espaulella-Panicot, Carles Codina-Jané
PURPOSE: Adverse drug events (ADEs) lead to adverse clinical outcomes such as hospitalization. There is little information about the characteristics of ADEs in patients with advanced chronic conditions and have a prognosis of limited life expectancy. This study aimed to evaluate (i) the prevalence of ADEs at the time of admission to hospital, (ii) the causality, severity, and preventability of the ADEs, and (iii) the clinical and pharmacological characteristics associated with the ADEs...
October 4, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27703082/fluorescent-parkin-cell-based-assay-development-for-the-screening-of-drugs-against-parkinson-disease
#5
Patricia Villacé, Rosa M Mella, Meritxell Roura-Ferrer, María Valcárcel, Clarisa Salado, Amaia Castilla, Danel Kortazar
Parkinson disease (PD) is a prevalent neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra, causing tremor and motor impairment. Parkin protein, whose mutants are the cause of Parkinson disease type 2 (PARK2), has been mechanistically linked to the regulation of apoptosis and the turnover of damaged mitochondria. Several studies have implicated aberrant mitochondria as a key contributor to the development of PD. In the attempt to discover new drugs, high-content cell-based assays are becoming more important to mimic the nature of biological processes and their diversifications in diseases and will be essential for lead identification and the optimization of therapeutic candidates...
October 4, 2016: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/27702766/five-year-optical-coherence-tomography-in-patients-with-st-segment-elevation-myocardial-infarction-treated-with-bare-metal-versus-everolimus-eluting-stents
#6
Josep Gomez-Lara, Salvatore Brugaletta, Francisco Jacobi, Luis Ortega-Paz, Marcos Ñato, Gerard Roura, Rafael Romaguera, Jose-Luis Ferreiro, Luis Teruel, Montserrat Gracida, Victoria Martin-Yuste, Xavier Freixa, Monica Masotti, Joan-Antoni Gomez-Hospital, Manel Sabate, Angel Cequier
BACKGROUND: The main causes of late (>1 month) stent thrombosis (ST) are stent uncoverage, malapposition, and neoatherosclerosis. First-generation drug-eluting stents were associated with higher rate of late ST compared with bare-metal stents (BMS), especially in patients with ST-segment-elevation myocardial infarction. Second-generation everolimus-eluting stents (EES) have shown similar rate of late ST than BMS. The aims of the study are to compare the ratio of uncovered to total struts per cross-section ≥30% and other optical coherence tomographic findings associated with ST between EES and BMS in patients with ST-segment-elevation myocardial infarction at 5 years...
October 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27686755/electromechanical-conditioning-of-adult-progenitor-cells-improves-recovery-of-cardiac-function-after-myocardial-infarction
#7
Aida Llucià-Valldeperas, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Benjamin Sanchez, Ramon Bragos, Gordana Vunjak-Novakovic, Antoni Bayes-Genis
: : Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. Our goals were (a) to study the viability of a tissue-engineered construct with cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs) and (b) to examine the effect of electromechanically stimulated cardiac ATDPCs within a myocardial infarction (MI) model in mice for the first time...
September 29, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27660998/theory-of-mind-in-euthymic-bipolar-patients-and-first-degree-relatives
#8
Josep Manel Santos, Esther Pousa, Estel Soto, Anna Comes, Pere Roura, Francesc X Arrufat, Jordi E Obiols
The present study analyzed the capacity for mentalization of patients with bipolar disorder (BD) and their first-degree relatives (FDR) and examined the implications of clinical variables and cognitive deficits. The study recruited 31 patients with type I BD, 18 FDR, and 31 paired healthy controls. Their capacity for mentalization was explored by means of first- and second-order false-belief tasks, the hinting task, and the Movie for the Assessment of Social Cognition (MASC). Patients and FDR were found to have a theory of mind (ToM) deficit when they were evaluated with the MASC, which was also related to a worse neurocognitive performance and to being a patient or FDR...
September 22, 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27658466/european-multicenter-study-on-antimicrobial-resistance-in-bacteria-isolated-from-companion-animal-urinary-tract-infections
#9
Cátia Marques, Luís Telo Gama, Adriana Belas, Karin Bergström, Stéphanie Beurlet, Alexandra Briend-Marchal, Els M Broens, Marta Costa, Delphine Criel, Peter Damborg, Marloes A M van Dijk, Astrid M van Dongen, Roswitha Dorsch, Carmen Martin Espada, Bernhard Gerber, Maria Kritsepi-Konstantinou, Igor Loncaric, Domenico Mion, Dusan Misic, Rebeca Movilla, Gudrun Overesch, Vincent Perreten, Xavier Roura, Joachim Steenbergen, Dorina Timofte, Georg Wolf, Renato Giulio Zanoni, Sarah Schmitt, Luca Guardabassi, Constança Pomba
BACKGROUND: There is a growing concern regarding the increase of antimicrobial resistant bacteria in companion animals. Yet, there are no studies comparing the resistance levels of these organisms in European countries. The aim of this study was to investigate geographical and temporal trends of antimicrobial resistant bacteria causing urinary tract infection (UTI) in companion animals in Europe. The antimicrobial susceptibility of 22 256 bacteria isolated from dogs and cats with UTI was determined...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27617397/brilliant-violet-fluorochromes-in-simultaneous-multicolor-flow-cytometry-fluorescence-in-situ-hybridization-measurement-of-monocyte-subsets-and-telomere-length-in-heart-failure
#10
Santiago Roura, Marco A Fernández, Elena Elchinova, Iris Teubel, Gerard Requena, Roser Cabanes, Josep Lupón, Antoni Bayes-Genis
Conventional analytical methods to determine telomere length (TL) have been replaced by more precise and reproducible procedures, such as fluorescence in situ hybridization coupled with flow cytometry (flow-FISH). However, simultaneous measurement of TL and cell phenotype remains difficult. Relatively expensive and time-consuming cell-sorting purification is needed to counteract the loss, due to stringent FISH conditions, of prehybridization fluorescence by the organic fluorochromes conventionally used in the phenotyping step...
September 12, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27598104/automated-tissue-segmentation-of-mr-brain-images-in-the-presence-of-white-matter-lesions
#11
Sergi Valverde, Arnau Oliver, Eloy Roura, Sandra González-Villà, Deborah Pareto, Joan C Vilanova, Lluís Ramió-Torrentà, Àlex Rovira, Xavier Lladó
Over the last few years, the increasing interest in brain tissue volume measurements on clinical settings has led to the development of a wide number of automated tissue segmentation methods. However, white matter lesions are known to reduce the performance of automated tissue segmentation methods, which requires manual annotation of the lesions and refilling them before segmentation, which is tedious and time-consuming. Here, we propose a new, fully automated T1-w/FLAIR tissue segmentation approach designed to deal with images in the presence of WM lesions...
August 30, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27591138/noninvasive-assessment-of-an-engineered-bioactive-graft-in-myocardial-infarction-impact-on-cardiac-function-and-scar-healing
#12
Carolina Gálvez-Montón, Ramon Bragós, Carolina Soler-Boti Ja, Idoia Díaz-Güemes, Cristina Prat-Vidal, Verónica Crisóstomo, Francisco M Sánchez-Margallo, Aida Llucià-Valldeperas, Paco Bogónez-Franco, Isaac Perea-Gil, Santiago Roura, Antoni Bayes-Genis
: : Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. The EBIG comprises a scaffold of decellularized human pericardium, green fluorescent protein-labeled porcine adipose tissue-derived progenitor cells (pATPCs), and a customized-design electrical impedance spectroscopy (EIS) monitoring system...
September 2, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27570507/automated-detection-of-lupus-white-matter-lesions-in-mri
#13
Eloy Roura, Nicolae Sarbu, Arnau Oliver, Sergi Valverde, Sandra González-Villà, Ricard Cervera, Núria Bargalló, Xavier Lladó
Brain magnetic resonance imaging provides detailed information which can be used to detect and segment white matter lesions (WML). In this work we propose an approach to automatically segment WML in Lupus patients by using T1w and fluid-attenuated inversion recovery (FLAIR) images. Lupus WML appear as small focal abnormal tissue observed as hyperintensities in the FLAIR images. The quantification of these WML is a key factor for the stratification of lupus patients and therefore both lesion detection and segmentation play an important role...
2016: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/27540513/the-effect-of-renal-diet-in-association-with-enalapril-or-benazepril-on-proteinuria-in-dogs-with-proteinuric-chronic-kidney-disease
#14
A Zatelli, X Roura, P D'Ippolito, M Berlanda, E Zini
Treating proteinuria in dogs reduces the progression of chronic kidney disease (CKD); renal diets and angiotensin-converting enzyme (ACE)-inhibitors are cornerstones of treatment. Whether different ACE-inhibitors have distinct kidney protective effects is unknown; it is therefore hypothesized that renal diets and enalapril or benazepril have different beneficial effects in proteinuric CKD dogs. Forty-four dogs with proteinuric CKD (IRIS stages 1-4) were enrolled in the study and were fed renal diet for 30 days...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27515332/cardiac-tissue-engineering-lost-in-translation-or-ready-for-translation
#15
EDITORIAL
Antoni Bayés-Genís, Carolina Gálvez-Montón, Santiago Roura
No abstract text is available yet for this article.
August 16, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27474020/countrywide-serological-evaluation-of-canine-prevalence-for-anaplasma-spp-borrelia-burgdorferi-sensu-lato-dirofilaria-immitis-and-ehrlichia-canis-in-mexico
#16
Rebeca Movilla, Carlos García, Susanne Siebert, Xavier Roura
BACKGROUND: Canine vector-borne diseases (CVBD) have become a major concern for canine and human public health. The aim of the study described here is to add epidemiological data regarding four pathogens responsible for CVBD, namely anaplasmosis, borreliosis, dirofilariosis and ehrlichiosis in a national survey conducted in Mexico. METHODS: Seventy-four veterinary centres located in 21 federal Mexican states were asked to test dogs with clinical signs suspect for CVBD and healthy dogs, for detection of Dirofilaria immitis antigen and antibodies against Anaplasma spp...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27463105/assessment-of-eating-habits-and-physical-activity-among-spanish-adolescents-the-cooking-and-active-leisure-tas-program
#17
Elena Roura, Raimon Milà-Villarroel, Sara Lucía Pareja, Alba Adot Caballero
Worldwide obesity has more than doubled in the last forty years. Even more worrying is the fact that the number of overweight and obese children and adolescents has considerably increased. Socioeconomic development, as well as educational, agricultural and marketing policies have significantly changed dietary and physical activity habits among the youngest, who are thus susceptible to develop chronic and disabling diseases such as diabetes, some cancers and cardiovascular disorders. Adolescence is a critical age, in which the adoption of healthy habits may have dramatic effects on the health state in adulthood...
2016: PloS One
https://www.readbyqxmd.com/read/27322478/first-in-man-safety-and-efficacy-of-the-adipose-graft-transposition-procedure-agtp-in-patients-with-a-myocardial-scar
#18
Antoni Bayes-Genis, Paloma Gastelurrutia, Maria-Luisa Cámara, Albert Teis, Josep Lupón, Cinta Llibre, Elisabet Zamora, Xavier Alomar, Xavier Ruyra, Santiago Roura, Ana Revilla, José Alberto San Román, Carolina Gálvez-Montón
BACKGROUND: The present study evaluates the safety and efficacy of the Adipose Graft Transposition Procedure (AGTP) as a biological regenerative innovation for patients with a chronic myocardial scar. METHODS: This prospective, randomized single-center controlled study included 10 patients with established chronic transmural myocardial scars. Candidates for myocardial revascularization were randomly allocated into two treatment groups. In the control arm (n=5), the revascularizable area was treated with CABG and the non-revascularizable area was left untouched...
May 2016: EBioMedicine
https://www.readbyqxmd.com/read/27289223/a-review-of-canine-babesiosis-the-european-perspective
#19
REVIEW
Laia Solano-Gallego, Ángel Sainz, Xavier Roura, Agustín Estrada-Peña, Guadalupe Miró
Canine babesiosis is a significant tick-borne disease caused by various species of the protozoan genus Babesia. Although it occurs worldwide, data relating to European infections have now been collected for many years. These data have boosted the publication record and increased our working knowledge of these protozoan parasites. Both the large and small forms of Babesia species (B. canis, B. vogeli, B. gibsoni, and B. microti-like isolates also referred to as "B. vulpes" and "Theileria annae") infect dogs in Europe, and their geographical distribution, transmission, clinical signs, treatment, and prognosis vary widely for each species...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27251904/clinical-leishmaniasis-in-dogs-living-in-the-uk
#20
P Silvestrini, D Batchelor, K Allenspach, C Maunder, M Seth, A Mas, T Hill, G Serrano, X Roura, M Planellas, A J German, J Pastor
OBJECTIVES: To investigate the prevalence of leishmaniasis in dogs in the UK and to describe clinical presentation, clinicopathological abnormalities, therapeutic protocols and outcome in this non-endemic country. MATERIALS AND METHODS: Medical records of dogs diagnosed with leishmaniasis at seven referral centres in the UK were retrospectively reviewed. RESULTS: The prevalence was between 0·007 and 0·04% with a higher number of cases in southern England...
September 2016: Journal of Small Animal Practice
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