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https://www.readbyqxmd.com/read/29743019/predictive-biomarkers-for-death-and-rehospitalization-in-comorbid-frail-elderly-heart-failure-patients
#1
Cristina Pacho, Mar Domingo, Raquel Núñez, Josep Lupón, Julio Núñez, Jaume Barallat, Pedro Moliner, Marta de Antonio, Javier Santesmases, Germán Cediel, Santiago Roura, M Cruz Pastor, Jordi Tor, Antoni Bayes-Genis
BACKGROUND: Heart failure (HF) is associated with a high rate of readmissions within 30 days post-discharge and in the following year, especially in frail elderly patients. Biomarker data are scarce in this high-risk population. This study assessed the value of early post-discharge circulating levels of ST2, NT-proBNP, CA125, and hs-TnI for predicting 30-day and 1-year outcomes in comorbid frail elderly patients with HF with mainly preserved ejection fraction (HFpEF). METHODS: Blood samples were obtained at the first visit shortly after discharge (4...
May 9, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29727961/pyrethroid-insecticide-lambda-cyhalothrin-induces-hepatic-cytochrome-p450-enzymes-oxidative-stress-and-apoptosis-in-rats
#2
María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, David Roura-Martínez, Victor Castellano, Bernardo Lopez-Torres, María-Rosa Martínez-Larrañaga, Arturo Anadón
This study aimed to examine in rats the effects of the Type II pyrethroid lambda-cyhalothrin on hepatic microsomal cytochrome P450 (CYP) isoform activities, oxidative stress markers, gene expression of proinflammatory, oxidative stress and apoptosis mediators, and CYP isoform gene expression and metabolism phase I enzyme PCR array analysis. Lambda-cyhalothrin, at oral doses of 1, 2, 4 and 8mg/kg bw for 6days, increased, in a dose-dependent manner, hepatic activities of ethoxyresorufin O-deethylase (CYP1A1), methoxyresorufin O-demethylase (CYP1A2), pentoxyresorufin O-depentylase (CYP2B1/2), testosterone 7α- (CYP2A1), 16β- (CYP2B1), and 6β-hydroxylase (CYP3A1/2), and lauric acid 11- and 12-hydroxylase (CYP4A1/2)...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29712965/head-to-head-comparison-of-two-engineered-cardiac-grafts-for-myocardial-repair-from-scaffold-characterization-to-pre-clinical-testing
#3
Isaac Perea-Gil, Carolina Gálvez-Montón, Cristina Prat-Vidal, Ignasi Jorba, Cristina Segú-Vergés, Santiago Roura, Carolina Soler-Botija, Oriol Iborra-Egea, Elena Revuelta-López, Marco A Fernández, Ramon Farré, Daniel Navajas, Antoni Bayes-Genis
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. We developed two engineered cardiac grafts, based on decellularized scaffolds from myocardial and pericardial tissues and repopulated them with adipose tissue mesenchymal stem cells (ATMSCs). The structure, macromechanical and micromechanical scaffold properties were preserved upon the decellularization and recellularization processes, except for recellularized myocardium micromechanics that was ∼2-fold stiffer than native tissue and decellularized scaffolds...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703984/author-correction-unravelling-the-effects-of-mechanical-physiological-conditioning-on-cardiac-adipose-tissue-derived-progenitor-cells-in-vitro-and-in-silico
#4
Aida Llucià-Valldeperas, Ramon Bragós, Carolina Soler-Botija, Santiago Roura, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Antoni Bayes-Genis
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29699668/polyphenolic-profile-of-butterhead-lettuce-cultivar-by-ultrahigh-performance-liquid-chromatography-coupled-online-to-uv-visible-spectrophotometry-and-quadrupole-time-of-flight-mass-spectrometry
#5
Gabriela E Viacava, Sara I Roura, Diana M López-Márquez, Luis A Berrueta, Blanca Gallo, Rosa M Alonso-Salces
In the present study, the butterhead lettuce cultivar was analyzed by ultrahigh performance liquid chromatography (UHPLC) coupled online to diode array detection (DAD), electrospray ionization (ESI) and quadrupole time-of-flight mass spectrometry (QToF/MS) in the positive and negative ion mode in order to characterize its polyphenolic profile for the first time. The instrument acquisition mode MSE was used to collect automatic and simultaneous information of exact mass at high and low collision energies of precursor ions as well as other ions produced as a result of their fragmentation...
September 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29690321/new-species-of-chnoodes-chevrolat-coleoptera-coccinellidae-from-french-guiana
#6
Thaysa C KrÜger, Julissa S Churata, Camila F Castro-Guedes, LÚcia M Almeida
Chnoodes Chevrolat, 1849 currently has 32 species described in South and Central America, with only one species, Chnoodes centralis Sicard, 1912 described from French Guiana. Here, C. centralis is redescribed and five new species are described: C. brulei sp. nov. (holotype male: Commune de Roura, Montagne des Chevaux), C. rubra sp. nov. (holotype male: Commune de Roura, Montagne des Chevaux), C. cerasus sp. nov. (holotype male: Commune de Roura, Montagne des Chevaux), C. tristis sp. nov. (holotype male: Commune de Kourou, Savane des Pères) and C...
March 21, 2018: Zootaxa
https://www.readbyqxmd.com/read/29687696/long-term-prognostic-impact-of-non-invasive-follow-up-with-computed-tomography-angiography-in-patients-with-left-main-coronary-artery-stenting
#7
Gerard Roura, Josep Gomez-Lara, Lara Fuentes Castillo, Josè L Ferreiro, Rafael Romaguera, Luis Teruel, Montserrat Gracida Blancas, Elena Carreño, Joan A Gomez-Hospital, Angel Cequier
BACKGROUND: Left main coronary artery (LMCA) stenting is an evolving technique. Whether follow-up computed tomography angiography (CTA) might have clinical impact in these patients is controversial. The aim of present study is to compare clinical outcomes of patients with LMCA stenting followed with CTA versus patients with conventional clinical follow-up. METHODS: From 2003 to 2014 all consecutive patients with unprotected LMCA stenosis treated with single DES implantation were prospectively included...
April 20, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29648675/clinical-features-of-chronic-spontaneous-urticaria-that-predict-disease-prognosis-and-refractoriness-to-standard-treatment
#8
Laia Curto-Barredo, Laura Riba Archilla, Guillem Roura Vives, Ramon M Pujol, Ana M Giménez-Arnau
Chronic spontaneous urticaria (CSU) is characterized by heterogeneous activity, evolution, associated comorbidities and response to treatment. The aim of this study was to identify prognostic factors in patients with CSU that predict disease course and response to standard treatments. An observational retrospective study was conducted in a cohort of 549 patients with CSU, comparing patients with isolated CSU and those with CSU with concomitant inducible urticaria (CSU-CIndU). The factors associated with a worse prognosis in terms of duration and/or CSU activity and its episodes were: multiple episodes of CSU (19...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29642901/profile-of-osteopathic-practice-in-spain-results-from-a-standardized-data-collection-study
#9
Gerard Alvarez Bustins, Pedro-Victor López Plaza, Sonia Roura Carvajal
BACKGROUND: There is limited research regarding patients' profiles and consumer attitudes and habits of osteopathy in Spain. The purpose of this study was to profile patients who regularly receive osteopathic care in Spain using an internationally developed standardized data collection tool. METHOD: During the period between April 2014 and December 2015, a UK-developed standardized data collection tool was distributed to Spanish osteopaths who voluntarily agreed to participate in this cross-sectional study...
April 11, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29616624/invasive-strategy-and-frailty-in-very-elderly-patients-with-acute-coronary-syndromes
#10
Isaac Llaó, Albert Ariza-Solé, Juan Sanchis, Oriol Alegre, Ramon López-Palop, Francesc Formiga, Francisco Marín, María T Vidán, Manuel Martínez-Sellés, Alessandro Sionis, Miguel Vives-Borrás, Joan Antoni Gómez-Hospital, Josep Gómez-Lara, Gerard Roura, Pablo Díez-Villanueva, Iván Núñez-Gil, Jaume Maristany, Lluis Asmarats, Héctor Bueno, Emad Abu-Assi, Àngel Cequier
AIMS: Current guidelines recommend an early invasive strategy in patients with non-ST segment elevation acute coronary syndromes (NSTEACS). The role of an invasive strategy in frail elderly patients remains controversial. METHODS AND RESULTS: The LONGEVO-SCA registry included unselected NSTEACS patients aged ≥80 years. A geriatric assessment was performed during hospitalization, including frailty. We evaluated the impact of an invasive strategy during the admission on the incidence of cardiac death, reinfarction or new revascularisation at 6-months...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29540862/proteomic-signature-of-circulating-extracellular-vesicles-in-dilated-cardiomyopathy
#11
Santiago Roura, Ana Gámez-Valero, Josep Lupón, Carolina Gálvez-Montón, Francesc E Borràs, Antoni Bayes-Genis
Dilated cardiomyopathy (DCM) remains a major cause of heart failure and carries a poor prognosis despite important advances in recent years. Better disease characterization using novel molecular techniques is needed to refine its progression. This study explored the proteomic signature of plasma-derived extracellular vesicles (EVs) obtained from DCM patients and healthy controls using size-exclusion chromatography (SEC). EV-enriched fractions were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS)...
March 14, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29509034/myocardial-healing-using-cardiac-fat
#12
Santiago Roura, Carolina Gálvez-Montón, Antoni Bayes-Genis
Chronic diseases, including myocardial scar healing and heart failure remission, impose huge social and economic burdens, and novel approaches are needed. Several therapeutic modalities are currently being evaluated, including cell therapy, stem cell conditioning, and cardiac tissue engineering. Areas covered: This review discusses the restoration of cardiac function after myocardial infarction using a vascularized flap of autologous cardiac adipose tissue over an akinetic scar. It addresses the risks and benefits of using cardiac adipose progenitors and the adipose graft transposition procedure (AGTP) to ameliorate cardiac dysfunction in preclinical and clinical trials...
April 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29494594/male-grower-pigs-fed-cereal-soluble-dietary-fibres-display-biphasic-glucose-response-and-delayed-glycaemic-response-after-an-oral-glucose-tolerance-test
#13
Anton M Pluschke, Barbara A Williams, Dagong Zhang, Stephen T Anderson, Eugeni Roura, Michael J Gidley
Acute and sustained soluble dietary fibre (SDF) consumption are both associated with improved glucose tolerance in humans and animal models (e.g. porcine). However, the effects on glucose tolerance in grower pigs, adapted to diets with a combination of SDF have not been studied previously. In this experiment, cereal SDF wheat arabinoxylan (AX) and oat β-glucan (BG) were fed individually and in combination to determine the effect on glucose tolerance in jugular vein catheterized grower pigs. Five groups of Large White male grower pigs were fed highly digestible diets containing either 10% AX, 10% BG, 5% AX with 5% BG, a model cereal whole wheat flour (WWF), or a control wheat starch diet (WS) with no SDF...
2018: PloS One
https://www.readbyqxmd.com/read/29464430/hiv-testing-and-counseling-among-female-sex-workers-a-systematic-literature-review
#14
Anna Tokar, Jacqueline E W Broerse, James Blanchard, Maria Roura
HIV testing uptake continues to be low among Female Sex Workers (FSWs). We synthesizes evidence on barriers and facilitators to HIV testing among FSW as well as frequencies of testing, willingness to test, and return rates to collect results. We systematically searched the MEDLINE/PubMed, EMBASE, SCOPUS databases for articles published in English between January 2000 and November 2017. Out of 5036 references screened, we retained 36 papers. The two barriers to HIV testing most commonly reported were financial and time costs-including low income, transportation costs, time constraints, and formal/informal payments-as well as the stigma and discrimination ascribed to HIV positive people and sex workers...
February 20, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29463269/telomere-attrition-in-heart-failure-a-flow-fish-longitudinal-analysis-of-circulating-monocytes
#15
Iris Teubel, Elena Elchinova, Santiago Roura, Marco A Fernández, Carolina Gálvez-Montón, Pedro Moliner, Marta de Antonio, Josep Lupón, Antoni Bayés-Genís
BACKGROUND: Cross-sectional investigations report shorter telomeres in patients with heart failure (HF); however, no studies describe telomere length (TL) trajectory and its relationship with HF progression. Here we aimed to investigate telomere shortening over time and its relationship to outcomes. METHODS: Our study cohort included 101 ambulatory patients with HF. Blood samples were collected at baseline (n = 101) and at the 1-year follow-up (n = 54). Using flow-FISH analysis of circulating monocytes, we simultaneously measured three monocyte subsets-classical (CD14++ CD16- ), intermediate (CD14++ CD16+ ), and nonclassical (CD14+ CD16++ )-and their respective TLs based on FITC-labeled PNA probe hybridization...
February 20, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29412765/nomad-biosensors-a-new-multiplexed-technology-for-the-screening-of-gpcr-ligands
#16
Rosa M Mella, Danel Kortazar, Meritxell Roura-Ferrer, Clarisa Salado, María Valcárcel, Amaia Castilla, Patricia Villacé
Nomad Technology (Innoprot [Innovative Technologies in Biological Systems], Derio, Spain), a novel tool for multiplexing high-throughput cell-based G protein-coupled receptor (GPCR) assays, is described in this work. This new technology comprises a family of fluorescent biosensors called Nomad Biosensors that allow for the measurement of responses mediated by G proteins through their interactions with second-messenger transduction proteins. GPCRs are one of the largest protein families of receptors in eukaryotes, and their signaling mediates important physiological processes within cells...
February 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29396233/in-vivo-evaluation-of-the-synergic-effect-of-metformin-and-mtor-inhibitors-on-the-endothelial-healing-of-drug-eluting-stents-in-diabetic-patients
#17
Héctor Cubero-Gallego, Rafael Romaguera, Josep Gómez-Lara, Joan A Gómez-Hospital, Manel Sabaté, Eduardo Pinar, Montserrat Gracida, Gerard Roura, José L Ferreiro, Luis Teruel, Cristian Tebé-Codorni, Pilar Jiménez-Quevedo, Eduard Montanya, Fernando Alfonso, Ángel Cequier
INTRODUCTION AND OBJECTIVES: Recent animal studies have shown metformin (MF) to impair endothelialization of drug-eluting stents (DES). The aim of this study was to evaluate the effect of MF on the healing of DES in human coronary arteries of patients with diabetes mellitus by optical coherence tomography (OCT). METHODS: The RESERVOIR trial randomized 116 lesions in 112 patients with diabetes mellitus to amphilimus- or everolimus-eluting stents and included mandatory OCT at 9 months of follow-up...
January 25, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29393600/temporal-trends-in-frequency-management-and-outcomes-of-coronary-perforations
#18
Agustín Fernández-Cisnal, Rafael Romaguera, Marcos Ñato, Josep Gómez-Lara, José L Ferreiro, Luis Teruel, Gerard Roura, Guillem Muntané-Carol, José González-Costello, Francisco Jacobi, Montserrat Gracida, Joan A Gómez-Hospital, Ángel Cequier
BACKGROUND: Coronary perforations (CP) have been described as a rare but potentially fatal complication in percutaneous coronary interventions (PCI). Our aim is to compare temporal trends in frequency, management and outcomes of coronary perforations (CP). METHODS: All cases of CP recorded in our prospective institutional percutaneous coronary intervention (PCI) registry from 2003 to 2015 were included. Patients were divided in 2 groups according to the time frame in which the CP occurred: the early period (before 2009, when the chronic total occlusions and primary PCI programs started) and the current period...
February 1, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29357372/inhibitors-of-trypanosoma-cruzi-sir2-related-protein-1-as-potential-drugs-against-chagas-disease
#19
Luís Gaspar, Ross P Coron, Paul KongThoo Lin, David M Costa, Begoña Perez-Cabezas, Joana Tavares, Meritxell Roura-Ferrer, Isbaal Ramos, Céline Ronin, Louise L Major, Fabrice Ciesielski, Iain K Pemberton, Jane MacDougall, Paola Ciapetti, Terry K Smith, Anabela Cordeiro-da-Silva
Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-related illness, causing significant mortality and morbidity. Due to the limited available therapeutic options, new drugs are urgently needed to control the disease. Sirtuins, also called Silent information regulator 2 (Sir2) proteins have long been suggested as interesting targets to treat different diseases, including parasitic infections...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29355984/pcr-evaluation-of-selected-vector-borne-pathogens-in-dogs-with-pericardial-effusion
#20
M-D Tabar, R Movilla, L Serrano, L Altet, O Francino, X Roura
OBJECTIVES: To investigate evidence for selected vector-borne pathogen infections in dogs with pericardial effusion living in a Mediterranean area in which several canine vector-borne diseases are endemic. MATERIALS AND METHODS: Archived EDTA blood (n=68) and pericardial fluid samples (n=58) from dogs with pericardial effusion (n=68) were included. Dogs without pericardial effusion examined for other reasons were included as controls (n=60). Pericardial effusion was classified as neoplastic in 40 dogs, idiopathic in 23 dogs and of unknown aetiology in 5 dogs...
April 2018: Journal of Small Animal Practice
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