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https://www.readbyqxmd.com/read/29343953/impact-of-acute-exacerbations-on-platelet-reactivity-in-chronic-obstructive-pulmonary-disease-patients
#1
Mariana Muñoz-Esquerre, José Luis Ferreiro, Daniel Huertas, Ana Lucrecia Marcano, Marta López-Sánchez, Gerard Roura, Joan Antoni Gómez-Hospital, Jordi Dorca, Angel Cequier, Salud Santos
Background: A higher risk of atherothrombotic cardiovascular events, which are platelet-driven processes, has been described during acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, the relevance of platelet reactivity during AECOPD and whether this is affected by antiplatelet agents are not fully elucidated to date. This study aimed to evaluate whether platelet reactivity is augmented during an exacerbation in COPD patients with and without antiplatelet therapy and its association with systemic inflammatory parameters...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29323152/unravelling-the-effects-of-mechanical-physiological-conditioning-on-cardiac-adipose-tissue-derived-progenitor-cells-in-vitro-and-in-silico
#2
Aida Llucià-Valldeperas, Ramon Bragós, Carolina Soler-Botija, Santiago Roura, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Antoni Bayes-Genis
Mechanical conditioning is incompletely characterized for stimulating therapeutic cells within the physiological range. We sought to unravel the mechanism of action underlying mechanical conditioning of adipose tissue-derived progenitor cells (ATDPCs), both in vitro and in silico. Cardiac ATDPCs, grown on 3 different patterned surfaces, were mechanically stretched for 7 days at 1 Hz. A custom-designed, magnet-based, mechanical stimulator device was developed to apply ~10% mechanical stretching to monolayer cell cultures...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29226304/successful-medical-management-of-pseudomembranous-cystitis-in-three-cats-with-lower-urinary-tract-obstruction
#3
A Vila, R Movilla, J Castro, C Mallol, R Novellas, Y Espada, X Roura
CASE REPORT: The present case series describes the clinical course and outcome of three cats diagnosed with pseudomembranous cystitis. This is an uncommon presentation of lower urinary tract obstruction but can be easily be identified by ultrasonography, revealing severe bladder wall thickening and thin hyperechoic luminal strips. The condition can be secondary to severe bacterial urinary tract infection. All cats were successfully treated with medical management only, mainly based on antimicrobials and individualised supportive therapy...
December 10, 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29209319/mesenchymal-stem-cells-induce-expression-of-cd73-in-human-monocytes-in-vitro-and-in-a-swine-model-of-myocardial-infarction-in-vivo
#4
Marta Monguió-Tortajada, Santiago Roura, Carolina Gálvez-Montón, Marcella Franquesa, Antoni Bayes-Genis, Francesc E Borràs
The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. This shifts the pro-inflammatory milieu induced by extracellular ATP to the anti-inflammatory regulation by Ado. Mesenchymal stem cells (MSCs) have potent immunomodulatory capabilities, including monocyte modulation toward an anti-inflammatory phenotype aiding tissue repair. In vitro, we observed that human cardiac adipose tissue-derived MSCs (cATMSCs) and umbilical cord MSCs similarly polarize monocytes toward a regulatory M2 phenotype, which maintained the expression of CD39 and induced expression of CD73 in a cell contact dependent fashion, correlating with increased functional activity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29203938/short-term-effects-of-dietary-supplementation-with-amino-acids-in-dogs-with-proteinuric-chronic-kidney-disease
#5
Andrea Zatelli, Paola D'Ippolito, Xavier Roura, Eric Zini
This retrospective study investigated the impact of amino acid supplementation on body weight, serum albumin, creatinine and urea concentrations, and urine protein-to-creatinine (UPC) ratio in proteinuric dogs with chronic kidney disease (CKD). Forty-six client-owned azotemic dogs with spontaneous proteinuric CKD already on a renal diet and in therapy with enalapril were included. After approximately 1 month of treatment (baseline), 29 dogs received oral amino acid supplementation daily (group A) and 17 dogs did not (group B)...
December 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29166126/nutrient-sensing-biology-in-mammals-and-birds
#6
Eugeni Roura, Simon R Foster
Nutrient sensing mechanisms have emerged as the fringe articulating nutritional needs with dietary choices. Carbohydrate, amino acid, fatty acid, mineral, and water sensing receptors are highly conserved across mammals and birds, consisting of a repertoire of 22 genes known to date. In contrast, bitter receptors are highly divergent and have a high incidence of polymorphisms within and between mammals and birds and are involved in the adaptation of species to specific environments. In addition, the expression of nutrient sensing genes outside the oral cavity seems to mediate the required decision-making dialogue between the gut and the brain by translating exogenous chemical stimuli into neuronal inputs, and vice versa, to translate the endogenous signals relevant to the nutritional status into specific appetites and the control of feed intake...
November 20, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29116007/prevalence-of-bartonella-spp-by-culture-pcr-and-serology-in-veterinary-personnel-from-spain
#7
José A Oteo, Ricardo Maggi, Aránzazu Portillo, Julie Bradley, Lara García-Álvarez, Montserrat San-Martín, Xavier Roura, Edward Breitschwerdt
BACKGROUND: The genus Bartonella includes fastidious, facultative intracellular bacteria mainly transmitted by arthropods and distributed among mammalian reservoirs. Bartonella spp. implicated as etiological agents of zoonoses are increasing. Apart from the classical Bartonella henselae, B. bacilliformis or B. quintana, other species (B. elizabethae, B. rochalimae, B. vinsonii arupensis and B. v. berkhoffii, B. tamiae or B. koehlerae, among others) have also been associated with human and/or animal diseases...
November 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29110749/salivary-leptin-and-tas1r2-tas1r3-polymorphisms-are-related-to-sweet-taste-sensitivity-and-carbohydrate-intake-from-a-buffet-meal-in-healthy-young-adults
#8
Pengfei Han, Russell S J Keast, Eugeni Roura
The influence of sweet taste sensitivity on food intake is not well understood. We investigated the involvement of salivary leptin and SNP of the sweet taste receptor genes (TAS1R2/TAS1R3) on sweet taste sensitivity, sensory-specific satiety (SSS) and macronutrient intake in healthy human adults. In all, nineteen high sweet sensitivity (HS) and eleven low sweet sensitivity (LS) subjects were classified based on the sweetness perception of one solution (9 mm sucrose) forced-choice triangle test. All participants completed a randomised crossover design experiment where they consumed one of three iso-energetic soup preloads differing in primary taste quality (sweet, non-sweet taste-control or no-taste energy-control)...
November 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29078809/mesenchymal-stem-cells-for-cardiac-repair-are-the-actors-ready-for-the-clinical-scenario
#9
REVIEW
Santiago Roura, Carolina Gálvez-Montón, Clémentine Mirabel, Joaquim Vives, Antoni Bayes-Genis
For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, treatment advances have not resolved the underlying problem of functional heart tissue loss. In this field of research, for years we have actively explored innovative biotherapies for cardiac repair. Here, we present a general, critical overview of our experience in using mesenchymal stem cells, derived from cardiac adipose tissue and umbilical cord blood, in a variety of cell therapy and tissue engineering approaches...
October 27, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29050839/recommendations-by-the-spanish-society-of-rheumatology-on-the-use-of-biological-therapies-in-axial-spondyloarthritis
#10
Jordi Gratacós, Petra Díaz Del Campo Fontecha, Cristina Fernández-Carballido, Xavier Juanola Roura, Luis Francisco Linares Ferrando, Eugenio de Miguel Mendieta, Santiago Muñoz Fernández, Jose Luis Rosales-Alexander, Pedro Zarco Montejo, Mercedes Guerra Rodríguez, Victoria Navarro Compán
OBJECTIVE: Recent data published on biological therapy in axial spondyloarthritis (axSpA) since the last publication of the recommendations of the Spanish Society of Rheumatology (SER) has led to the generation of a review of these recommendations based on the best possible evidence. These recommendations should be a reference for rheumatologists and those involved in the treatment of patients with axSpA. METHODS: Recommendations were drawn up following a nominal group methodology and based on systematic reviews...
October 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28943494/association-between-coronary-atherosclerosis-progression-and-in-stent-neoatherosclerosis-in-patients-with-st-elevation-myocardial-infarction-at-5-years-follow-up
#11
Giulia Paoletti, Josep Gomez-Lara, Salvatore Brugaletta, Marcos Ñato, Rafael Romaguera, Gerard Roura, José-Luis Ferreiro, Luis Teruel, Montserrat Gracida, Luis Ortega-Paz, Joan-Antoni Gomez-Hospital, Manel Sabate, Angel Cequier
AIMS: To investigate the association between in-stent neoatherosclerosis (NA) and atherosclerosis progression (AP) in non-culprit segments in patients with ST-elevation myocardial infarction at 5 years. METHODS AND RESULTS: Sixty-two out of 169 consecutive patients included in the EXAMINATION study underwent optical coherence tomography (OCT) at 5 years. NA plaques were observed in 13 (21.0%), signal-rich bands (SRB) in 22 (35.5%) and AP in 11 (17.7%). NA plaques were more frequently observed in patients treated with two stents (53...
September 26, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28935085/early-collapse-of-a-magnesium%C3%A2-bioresorbable-scaffold
#12
Hector Cubero-Gallego, Bert Vandeloo, Josep Gomez-Lara, Rafael Romaguera, Gerard Roura, Joan A Gomez-Hospital, Angel Cequier
No abstract text is available yet for this article.
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28918450/clinical-utility-of-the-asdas-index-in-comparison-with-basdai-in-patients-with-ankylosing-spondylitis-axis-study
#13
Agustí Sellas I Fernandez, Xavier Juanola Roura, Alberto Alonso Ruiz, José Rosas, Julio Medina Luezas, Eduardo Collantes Estevez, Miguel Ángel Abad Hernández, Virginia Carrasco Benitez, Cesar Fisac
The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observational study in patients with AS (NY-modified criteria) from 23 Spanish centers. Physical and analytical data; global, lumbar, and nocturnal pain; ASDAS, BASDAI and minimally acceptable clinical status (PASS) were collected...
November 2017: Rheumatology International
https://www.readbyqxmd.com/read/28898946/towards-the-understanding-of-antibiotic-occurrence-and-transport-in-groundwater-findings-from-the-baix-fluvi%C3%A3-alluvial-aquifer-ne-catalonia-spain
#14
M Boy-Roura, J Mas-Pla, M Petrovic, M Gros, D Soler, D Brusi, A Menció
Antibiotics are an increasing focus of interest due to their high detection frequency in the environment. However, their presence in water bodies is not regulated by environmental policies. This field study investigates, for the first time, the occurrence, behavior and fate of a selection of 53 antibiotics, including up to 10 chemical groups, in an alluvial aquifer originated from manure application in an agricultural region using hydrogeological, hydrochemical and isotopic approaches. Up to 11 antibiotics were found in groundwater corresponding to 4 different chemical groups: fluoroquinolones, macrolides, quinolones and sulfonamides...
January 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28882616/screening-of-inflammatory-bowel-disease-and-spondyloarthritis-for-referring-patients-between-rheumatology-and-gastroenterology
#15
Jesús Sanz Sanz, Xavier Juanola Roura, Daniel Seoane-Mato, Miguel Montoro, Fernando Gomollón
OBJECTIVE: To define clinical screening criteria for spondyloarthritis (SpA) in patients with inflammatory bowel disease (IBD) and vice versa, which can be used as a reference for referring them to the rheumatology or gastroenterology service. METHOD: Systematic literature review and a two-round Delphi method. The scientific committee and the expert panel were comprised of 2 rheumatologists and 2 gastroenterologists, and 7 rheumatologists and 7 gastroenterologists, respectively...
September 4, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28870640/ivus-findings-in-late-and-very-late-stent-thrombosis-a-comparison-between-bare-metal-and-drug-eluting-stents
#16
Lara Fuentes, Josep Gómez-Lara, Neus Salvatella, Nieves Gonzalo, Felipe Hernández-Hernández, Eduard Fernández-Nofrerias, Ángel Sánchez-Recalde, Fernando Alfonso, Rafael Romaguera, José Luis Ferreiro, Gerard Roura, Luis Teruel, Montserrat Gracida, Ana Lucrecia Marcano, Joan-Antoni Gómez-Hospital, Ángel Cequier
INTRODUCTION AND OBJECTIVES: Stent thrombosis (ST) is a life-threatening complication after stent implantation. Intravascular ultrasound is able to discern most causes of ST. The aim of this study was to compare intravascular ultrasound findings between bare-metal stents (BMS) and drug-eluting stents (DES) in patients with late (31 days to 1 year) or very late ST (> 1 year). METHODS: Of 250 consecutive patients with late or very late ST in 7 Spanish institutions, 114 patients (45...
September 1, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28863429/biotherapies-and-biomarkers-for-cardiovascular-diseases-a-15-year-journey-at-the-icrec-heart-failure-and-cardiac-regeneration-research-laboratory-in-barcelona-spain
#17
Santiago Roura, Carolina Gálvez-Montón, Josep Lupón, Antoni Bayes-Genis
No abstract text is available yet for this article.
June 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28860996/prey-capture-ingestion-and-digestion-dynamics-of-octopus-vulgaris-paralarvae-fed-live-zooplankton
#18
Manuel Nande, Pablo Presa, Álvaro Roura, Paul L R Andrews, Montse Pérez
Octopus vulgaris is a species of great interest in research areas such as neurobiology, ethology, and ecology but also a candidate species for aquaculture as a food resource and for alleviating the fishing pressure on its wild populations. This study aimed to characterize the predatory behavior of O. vulgaris paralarvae and to quantify their digestive activity. Those processes were affordable using the video-recording analysis of 3 days post-hatching (dph), mantle-transparent paralarvae feeding on 18 types of live zooplanktonic prey...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28833875/characterization-of-phenolic-compounds-in-green-and-red-oak-leaf-lettuce-cultivars-by-uhplc-dad-esi-qtof-ms-using-ms-e-scan-mode
#19
Gabriela E Viacava, Sara I Roura, Luis A Berrueta, Carmen Iriondo, Blanca Gallo, Rosa M Alonso-Salces
Lettuce (Lactuca sativa) is one of the most popular leafy vegetables in the world and constitutes a major dietary source of phenolic compounds with health promoting properties. In particular, the demand for green and red oak-leaf lettuces have considerably increased in the last years but few data on their polyphenol composition is available. Moreover, the utilization of analytical edge technology can provide new structural information and allow the identification of unknown polyphenols. In the present study the phenolic profiles of green and red oak-leaf lettuce cultivars were exhaustively characterized by ultrahigh performance liquid chromatography (UHPLC) coupled online to diode array detection (DAD), electrospray ionization (ESI) and quadrupole time-of-flight mass spectrometry (QToF/MS), using the MS(E) instrument acquisition mode for recording simultaneously exact masses of precursor and fragment ions...
August 22, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28789915/association-of-general-and-abdominal-obesity-with-hypertension-dyslipidemia-and-prediabetes-in-the-predaps-study
#20
F Javier Sangrós, Jesús Torrecilla, Carolina Giráldez-García, Lourdes Carrillo, José Mancera, Teresa Mur, Josep Franch, Javier Díez, Albert Goday, Rosario Serrano, F Javier García-Soidán, Gabriel Cuatrecasas, Dimas Igual, Ana Moreno, J Manuel Millaruelo, Francisco Carramiñana, Manuel Antonio Ruiz, Francisco Carlos Pérez, Yon Iriarte, Ángela Lorenzo, María González, Beatriz Álvarez, Lourdes Barutell, M Soledad Mayayo, Mercedes Del Castillo, Emma Navarro, Fernando Malo, Ainhoa Cambra, Riánsares López, M Ángel Gutiérrez, Luisa Gutiérrez, Carmen Boente, J Javier Mediavilla, Luis Prieto, Luis Mendo, M José Mansilla, Francisco Javier Ortega, Antonia Borras, L Gabriel Sánchez, J Carlos Obaya, Margarita Alonso, Francisco García, Ángela Trinidad Gutiérrez, Ana M Hernández, Dulce Suárez, J Carlos Álvarez, Isabel Sáenz, F Javier Martínez, Ana Casorrán, Jazmín Ripoll, Alejandro Salanova, M Teresa Marín, Félix Gutiérrez, Jaime Innerárity, M Del Mar Álvarez, Sara Artola, M Jesús Bedoya, Santiago Poveda, Fernando Álvarez, M Jesús Brito, Rosario Iglesias, Francisca Paniagua, Pedro Nogales, Ángel Gómez, José Félix Rubio, M Carmen Durán, Julio Sagredo, M Teresa Gijón, M Ángeles Rollán, Pedro P Pérez, Javier Gamarra, Francisco Carbonell, Luis García-Giralda, J Joaquín Antón, Manuel de la Flor, Rosario Martínez, José Luis Pardo, Antonio Ruiz, Raquel Plana, Ramón Macía, Mercè Villaró, Carmen Babace, José Luis Torres, Concepción Blanco, Ángeles Jurado, José Luis Martín, Jorge Navarro, Gloria Sanz, Rafael Colas, Blanca Cordero, Cristina de Castro, Mercedes Ibáñez, Alicia Monzón, Nuria Porta, María Del Carmen Gómez, Rafael Llanes, J José Rodríguez, Esteban Granero, Manuel Sánchez, Juan Martínez, Patxi Ezkurra, Luis Ávila, Carlos de la Sen, Antonio Rodríguez, Pilar Buil, Paula Gabriel, Pilar Roura, Eduard Tarragó, Xavier Mundet, Remei Bosch, J Carles González, M Isabel Bobé, Manel Mata, Irene Ruiz, Flora López, Marti Birules, Oriol Armengol, Rosa Mar de Miguel, Laura Romera, Belén Benito, Neus Piulats, Beatriz Bilbeny, J José Cabré, Xavier Cos, Ramón Pujol, Mateu Seguí, Carmen Losada, A María de Santiago, Pedro Muñoz, Enrique Regidor
INTRODUCTION AND OBJECTIVES: Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin). METHODS: Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase)...
August 5, 2017: Revista Española de Cardiología
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