keyword
https://read.qxmd.com/read/38528696/dark-blood-computed-tomography-angiography-combined-with-deep-learning-reconstruction-for-cervical-artery-wall-imaging-in-takayasu-arteritis
#21
JOURNAL ARTICLE
Tong Su, Zhe Zhang, Yu Chen, Yun Wang, Yumei Li, Min Xu, Jian Wang, Jing Li, Xinping Tian, Zhengyu Jin
OBJECTIVE: To evaluate the image quality of novel dark-blood computed tomography angiography (CTA) imaging combined with deep learning reconstruction (DLR) compared to delayed-phase CTA images with hybrid iterative reconstruction (HIR), to visualize the cervical artery wall in patients with Takayasu arteritis (TAK). MATERIALS AND METHODS: This prospective study continuously recruited 53 patients with TAK (mean age: 33.8 ± 10.2 years; 49 females) between January and July 2022 who underwent head-neck CTA scans...
April 2024: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://read.qxmd.com/read/38528527/association-between-dental-age-and-malocclusions-a-systematic-review
#22
Gabriela Fonseca-Souza, Amanda Renostro-Souza, Lhorrany Alves-Souza, Geraldo Thedei Junior, Maria Angélica Hueb de Menezes-Oliveira, Lívia Azeredo Alves Antunes, Svenja Beisel-Memmert, Christian Kirschneck, Juliana Feltrin-Souza, Erika Calvano Küchler
BACKGROUND: The evidence in the literature suggests that some skeletal or dental malocclusions are involved with dental development, resulting in advanced or delayed dental age (DA). The purpose of this systematic review was to investigate the association between DA and different types of malocclusions. METHODS: The search was carried out on PubMed, Scopus, Web of Science, Virtual Health Library, and in the gray literature. Observational studies that evaluated the association between DA and sagittal, vertical, or transversal malocclusions were included...
March 25, 2024: BMC Oral Health
https://read.qxmd.com/read/38527154/diagnostic-performance-of-carotid-ring-sign-on-ct-angiography-in-internal-carotid-true-occlusion
#23
JOURNAL ARTICLE
Tingyu Yi, Yi Sui, Dinghuan Zheng, Xinwen Ren, Xiaohui Lin, Yanmin Wu, Dinglai Lin, Zhinan Pan, Xiufen Zheng, Ganji Hong, Meihua Wu, Lisan Zeng, Wenhuo Chen
BACKGROUND: To differentiate between pseudo occlusion (PO) and true occlusion (TO) of internal carotid artery (ICA) is important in thrombectomy treatment planning for patients with acute ischemic stroke. Although delayed contrast filling has been differentiated carotid PO from TO, its application has been limited by the implementations of multiphasic computed tomography angiography. In this study, we hypothesized that carotid ring sign, which is readily acquired from single-phasic CTA, can sufficiently differentiate carotid TO from PO...
April 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38526987/-i-suppose-in-our-culture-old-means-no-sex-plwh-and-healthcare-provider-views-on-factors-influencing-late-hiv-testing-and-diagnosis-among-older-adults-in-malaysia
#24
JOURNAL ARTICLE
Hoi Yee Wong, Reena Rajasuriar, Pui Li Wong, Yew Kong Lee
The proportion of new HIV diagnoses among older adults aged ≥50 years continues to rise. Older adults are at higher risk of late diagnosis which is associated with higher treatment complexity and poorer health outcomes. Few studies in the Asia-Pacific region have explored factors contributing to late presentation and diagnosis in this population. Thus, our study aimed to explore factors influencing late HIV diagnosis among older adults ≥50 years in Malaysia. We conducted in-depth interviews with 16 older adults newly diagnosed with HIV (OPLWH) and focus group discussions with seven healthcare providers (HCPs) from different specialties in an academic tertiary hospital in Malaysia...
March 25, 2024: AIDS Care
https://read.qxmd.com/read/38526462/high-efficacy-therapy-discontinuation-vs-continuation-in-patients-50-years-and-older-with-nonactive-ms
#25
JOURNAL ARTICLE
Guillaume Jouvenot, Guilhem Courbon, Mathilde Lefort, Fabien Rollot, Romain Casey, Emmanuelle Le Page, Laure Michel, Gilles Edan, Jérome de Seze, Laurent Kremer, Kevin Bigaut, Sandra Vukusic, Guillaume Mathey, Jonathan Ciron, Aurélie Ruet, Elisabeth Maillart, Pierre Labauge, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun-Frenay, Thibault Moreau, David Axel Laplaud, Eric Berger, Bruno Stankoff, Pierre Clavelou, Eric Thouvenot, Olivier Heinzlef, Jean Pelletier, Abdullatif Al-Khedr, Olivier Casez, Bertrand Bourre, Philippe Cabre, Abir Wahab, Laurent Magy, Jean-Philippe Camdessanché, Ines Doghri, Solène Moulin, Haifa Ben-Nasr, Céline Labeyrie, Karolina Hankiewicz, Jean-Philippe Neau, Corinne Pottier, Chantal Nifle, Nicolas Collongues, Anne Kerbrat
IMPORTANCE: A recent randomized clinical trial concluded that discontinuing medium-efficacy therapy might be a reasonable option for older patients with nonactive multiple sclerosis (MS), but there is a lack of data on discontinuing high-efficacy therapy (HET). In younger patients, the discontinuation of natalizumab and fingolimod is associated with a risk of rebound of disease activity. OBJECTIVE: To determine whether discontinuing HET in patients 50 years and older with nonactive MS is associated with an increased risk of relapse compared with continuing HET...
March 25, 2024: JAMA Neurology
https://read.qxmd.com/read/38525759/hemophagocytic-lymphohistiocytosis-hlh-in-patients-with-tick-borne-illness-a-scoping-review-of-98-cases
#26
REVIEW
Dorde Jevtic, Marilia Dagnon da Silva, Alberto Busmail Haylock, Charles W Nordstrom, Stevan Oluic, Nikola Pantic, Milan Nikolajevic, Nikola Nikolajevic, Magdalena Kotseva, Igor Dumic
Hemophagocytic lymphohistiocytosis (HLH) secondary to tick-borne infections is a rare but potentially life-threatening syndrome. We performed a scoping review according to PRISMA guidelines to systematically analyze the existing literature on the topic. A total of 98 patients were included, with a mean age of 43.7 years, of which 64% were men. Most cases, 31%, were reported from the USA. Immunosuppression was present in 21.4%, with the most common cause being previous solid organ transplantation. Constitutional symptoms were the most common, observed in 83...
February 21, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38525478/hepatic-involvement-in-acquired-immunodeficiency-syndrome-associated-kaposi-s-sarcoma-a-descriptive-analysis-on-ct-mri-and-ultrasound
#27
JOURNAL ARTICLE
Chun-Shuang Guan, Jing Yu, Yan-Ni Du, Xin-Gang Zhou, Zi-Xin Zhang, Hui Chen, Yu-Xue Xing, Ru-Ming Xie, Zhi-Bin Lv
PURPOSE: To retrospectively analyse the different imaging manifestations of acquired immunodeficiency syndrome-associated hepatic Kaposi's sarcoma (AIDS-HKS) on CT, MRI, and Ultrasound. PATIENTS AND METHODS: Eight patients were enrolled in the study. Laboratory tests of liver function were performed. The CT, MRI, and Ultrasound manifestations were reviewed by two radiologists and two sonographers, respectively. The distribution and imaging signs of AIDS-HKS were evaluated...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38524268/cluster-headache-an-update-on-clinical-features-epidemiology-pathophysiology-diagnosis-and-treatment
#28
REVIEW
Daniel San-Juan, Karina Velez-Jimenez, Jan Hoffmann, Adriana Patricia Martínez-Mayorga, Agustín Melo-Carrillo, Ildefonso Rodríguez-Leyva, Silvia García, Miguel Ángel Collado-Ortiz, Erwin Chiquete, Manuel Gudiño-Castelazo, Humberto Juárez-Jimenez, Marco Martínez-Gurrola, Alejandro Marfil, Juan Alberto Nader-Kawachi, Paul David Uribe-Jaimes, Rubén Darío-Vargas, Jorge Villareal-Careaga
Cluster headache (CH) is one of the worst primary headaches that remain underdiagnosed and inappropriately treated. There are recent advances in the understanding of this disease and available treatments. This paper aims to review CH's recent clinical and pathophysiological findings, diagnosis, and treatment. We performed a narrative literature review on the socio-demographics, clinical presentations, pathophysiological findings, and diagnosis and treatment of CH. CH affects 0.1% of the population with an incidence of 2...
2024: Front Pain Res (Lausanne)
https://read.qxmd.com/read/38523584/evaluation-of-diagnostic-and-therapeutic-delay-in-patients-with-rheumatoid-arthritis-and-psoriatic-arthritis
#29
JOURNAL ARTICLE
M Iacovantuono, S Ferrigno, P Conigliaro, P Triggianese, A D'Antonio, F R Spinelli, A Bergamini, M S Chimenti
OBJECTIVE: A monocentric cross-sectional study recruiting rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients residing in the Lazio region, Italy, to assess factors related to diagnostic delay and treatment accessibility. METHODS: Clinical/serological data, including the time between symptom onset, diagnosis, and the beginning of treatment, were collected. Residence, referral to a rheumatologic center, physician who made the diagnosis, and previous misdiagnosis were also evaluated...
March 22, 2024: Reumatismo
https://read.qxmd.com/read/38522331/enhanced-accuracy-and-reduced-delay-in-diagnosing-bone-tumors-within-an-expert-sarcoma-network-a-nationwide-study
#30
JOURNAL ARTICLE
Vincent Crenn, François Lataste, Louise Galmiche, Louis-Romée Le Nail, Mickaël Ropars, Jean-Yves Blay, Gonzague de Pinieux, Francois Gouin
INTRODUCTION: Primary bone tumors encompass a range of rare and diverse lesions. Pathological diagnosis poses significant challenges, with histological discrepancies extensively studied in soft tissue sarcomas but lacking specific investigation in bone lesions. This study aimed to determine the rate of major diagnostic discrepancies in primary bone tumors, assessing whether initial histological analysis within an expert referral center network reduces this rate and final diagnostic delay...
March 18, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38522222/a-novel-center-based-deep-contrastive-metric-learning-method-for-the-detection-of-polymicrogyria-in-pediatric-brain-mri
#31
JOURNAL ARTICLE
Lingfeng Zhang, Nishard Abdeen, Jochen Lang
Polymicrogyria (PMG) is a disorder of cortical organization mainly seen in children, which can be associated with seizures, developmental delay and motor weakness. PMG is typically diagnosed on magnetic resonance imaging (MRI) but some cases can be challenging to detect even for experienced radiologists. In this study, we create an open pediatric MRI dataset (PPMR) containing both PMG and control cases from the Children's Hospital of Eastern Ontario (CHEO), Ottawa, Canada. The differences between PMG and control MRIs are subtle and the true distribution of the features of the disease is unknown...
March 21, 2024: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://read.qxmd.com/read/38522173/factors-influencing-the-time-to-diagnosis-and-treatment-of-breast-cancer-among-women-in-low-and-middle-income-countries-a-systematic-review
#32
REVIEW
Ranjeeta Subedi, Nehmat Houssami, Carolyn Nickson, Anant Nepal, Denise Campbell, Michael David, Xue Qin Yu
PURPOSE: Shorter time from symptoms recognition to diagnosis and timely treatment would be expected to improve the survival of patients with breast cancer (BC). This review identifies and summarizes evidence on time to diagnosis and treatment, and associated factors to inform an improved BC care pathways in Low- and Middle-Income Countries (LMICs). METHODS: A systematic search was conducted in electronic databases including Medline, Embase, PsycINFO and Global Health, covering publications between January 1, 2010, and November 6, 2023...
March 18, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38521969/cystic-lung-changes-bronchiectasis-and-a-heterozygous-primary-ciliary-dyskinesia-associated-variant-in-the-dnah5-gene-a-diagnostic-challenge
#33
JOURNAL ARTICLE
Manal Albalawi, Abdullah Al-Shamrani, Ahmed Sarar Mohamed, Sarar Mohamed
BACKGROUND Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disease that can present at different ages with different phenotypes. Missed and delayed diagnoses are fairly common. Many variants in the DNAH5 gene have been described that confirm the diagnosis of PCD. Advances in medicine, especially in molecular genetics, have led to increasingly early discoveries of such cases, especially in those with nonclassical presentations. CASE REPORT This report describes a patient with bronchiectasis, lung cysts, finger clubbing, and failure to thrive who was misdiagnosed for several years as having asthma...
March 24, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38521735/time-to-diagnosis-and-its-predictors-in-syndromes-associated-with-frontotemporal-lobar-degeneration
#34
JOURNAL ARTICLE
Ilenia Libri, Daniele Altomare, Valeria Bracca, Jasmine Rivolta, Valentina Cantoni, Irene Mattioli, Antonella Alberici, Barbara Borroni
OBJECTIVES: Frontotemporal Lobar Degeneration (FTLD) causes a heterogeneous group of neurodegenerative disorders with a wide range of clinical features. This might delay time to diagnosis. The aim of the present study is to establish time to diagnosis and its predictors in patients with FTLD-associated syndromes. DESIGN: Retrospective study. SETTING: Tertiary referral center. PARTICIPANTS: A total of 1029 patients with FTLD-associated syndromes (age: 68 [61-73] years, females: 46%) from 1999 to 2023 were included in the present study...
March 7, 2024: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/38520642/prevalence-and-diagnostic-journey-of-friedreich-s-ataxia-in-the-state-of-s%C3%A3-o-paulo-brazil
#35
JOURNAL ARTICLE
Daiana Suelen Machado, Celiana Figueiredo Viana, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Pedro José Tomaselli, Wilson Marques, Thiago J R Rezende, Alberto R M Martinez, Marcondes Cavalcante França
Friedreich's Ataxia (FRDA) is the leading cause of ataxia worldwide, but data on epidemiology and diagnostic journey are scarce, particularly in Latin America. Herein we estimated the prevalence of FRDA in the most populous Brazilian state and characterized the diagnostic odyssey of the disease. We received anonymized data of patients with FRDA from advocacy groups and physicians. Prevalence was estimated dividing the number of patients by the population of the state as reported in the last census. Patients were invited to answer an online survey to describe clinical data and diagnostic journey of the disease...
March 23, 2024: Cerebellum
https://read.qxmd.com/read/38520545/exosomes-in-renal-cell-carcinoma-challenges-and-opportunities
#36
REVIEW
Mahan Mohammadi, Kamran Mansouri, Pantea Mohammadi, Mehran Pournazari, Houshang Najafi
Renal cell carcinoma (RCC) is the most common type of kidney cancer that accounts for approximately 2-3% of adult malignancies. Among the primary treatment methods for this type of cancer are surgery and targeted treatment. Still, due to less than optimal effectiveness, there are problems such as advanced distant metastasis, delayed diagnosis, and drug resistance that continue to plague patients. In recent years, therapeutic advances have increased life expectancy and effective treatment in renal cell carcinoma patients...
March 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38520260/undiagnosed-rare-disease-clinic-identifies-a-novel-ube3a-variant-in-two-sisters-with-angelman-syndrome-the-end-of-a-diagnostic-odyssey
#37
JOURNAL ARTICLE
Rebecca Bruns, Khurram Liaqat, Abdul Nasir, Kayla Treat, Vinaya S Murthy, Lili Mantcheva, Wilfredo Torres, Erin Conboy, Francesco Vetrini
Angelman syndrome (AS, MIM #105830) is a neurodevelopmental disorder characterized by severe intellectual disability, profound developmental delay, movement or balance problems, an excessively cheerful disposition, and seizures. AS results from inadequate expression of the maternal UBE3A gene (MIM #601623), which encodes an E3 ligase in the ubiquitin-proteasome pathway. Here we present the case of two sisters with features consistent with AS who had negative methylation analyses. An autism/intellectual disability expanded panel revealed a maternally inherited novel UBE3A (NM_001354506...
March 23, 2024: Congenital Anomalies
https://read.qxmd.com/read/38520242/evaluation-of-the-management-of-gastroschisis-in-aristide-le-dantec-university-hospital-center-in-dakar
#38
JOURNAL ARTICLE
Souleymane Camara, Daniel Yonga Tenfa, S Y Fatou, Fall Yacine, Mbaye Fall, Oumar Ndour
INTRODUCTION: The management of gastroschisis remains problematic in low- and middle-income countries with high perioperative mortality. The objective of this work was to make an initial assessment of our management of gastroschisis. MATERIALS AND METHODS: This was a monocentric and cross-sectional study including all newborns with gastroschisis between January 2017 and December 2021 in the Pediatric Surgery and Anesthesia Resuscitation Department of the Aristide Le Dantec University Hospital Center from Dakar...
March 14, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38518896/standardisation-of-definition-and-management-for-bleeding-disorder-of-unknown-cause-communication-from-the-ssc-of-the-isth
#39
Ross I Baker, Philip Choi, Nicola Curry, Johanna Gebhart, Keith Gomez, Yvonne Henskens, Floor Heubel-Moenen, Paula James, Rezan Abdul Kadir, Peter Kouides, Michelle Lavin, Marie Lordkipanidze, Gillian Lowe, Andrew Mumford, Nicola Mutch, Michael Nagler, Maha Othman, Ingrid Pabinger, Robert Sidonio, Will Thomas, James S O'Donnell
In many patients referred with significant bleeding phenotype, laboratory testing fails to define any hemostatic abnormalities. Clinical practise with respect to diagnosis and management of this patient cohort poses significant clinical challenges. We recommend that bleeding history in these patients should be objectively assessed using the ISTH bleeding assessment tool (BAT). Patients with increased BAT scores should progress to hemostasis laboratory testing. To diagnose BDUC, normal complete blood count, prothrombin time, activated partial thromboplastin time, thrombin time, von Willebrand factor antigen, von Willebrand factor function; coagulation factors VIII, IX and XI and platelet light transmission aggregometry (LTA) should be the minimum laboratory assessment...
March 20, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38518474/primary-extrahepatic-hydatid-cyst-of-the-thigh-an-unusual-presentation-of-sciatica-a-case-report-of-a-diagnostic-challenge
#40
Ahmed Zendeoui, Mohamed Amine Gharbi, Mouadh Nefiss, Mohamed Hedi Ezzine, Anis Tborbi, Ramzi Bouzidi
INTRODUCTION: Sciatica, a condition characterized by pain along the sciatic nerve distribution, is commonly associated with nerve compression or irritation. However, its etiology can vary, including rare non-spinal causes such as hydatid cysts. We present a case of hydatid cyst in the thigh causing sciatica-like symptoms, highlighting the diagnostic challenges and management approach. CASE PRESENTATION: A 40-year-old patient with a history of pulmonary tuberculosis presented with persistent lumbosciatic pain despite conservative treatment...
March 20, 2024: International Journal of Surgery Case Reports
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