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https://www.readbyqxmd.com/read/29052830/diaphragmatic-rupture-a-single-institution-experience-and-literature-review
#1
Carlo Corbellini, Stefano Costa, Tiberio Canini, Roberta Villa, Ettore Contessini Avesani
BACKGROUND: Diaphragmatic rupture (DR) is a rare and potentially life-threatening event caused by trauma or spontaneously. DR occasionally occurs several months after the injury. Chest X-ray and computed tomography are the most effective diagnostic methods. Delay in DR diagnosis occurs frequently. This study aimed to examine and improve our understanding of the etiology, clinical presentation, and management of DR. METHODS: This study was performed at the Emergency and General Surgery Department of Fondazione I...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29051883/early-motor-delay-an-outstanding-initial-sign-of-osteogenesis-imperfecta-type-1
#2
Vito Pavone, Teresa Mattina, Piero Pavone, Raffaele Falsaperla, Gianluca Testa
INTRODUCTION: Osteogenesis imperfect (OI) is a heterogeneous and complex connective tissue disorder that manifests with low bone density and fragility. More than 15 types of OI have been distinguished on a clinical and molecular basis, but the classical clinical classification previously proposed in Types 1-4 with the recent inclusion of Type 5 appears to be more suitable. The diagnosis is mainly made on clinical and radiographic findings with fractures caused by mild trauma, bowing deformities of long bones, and growth deficiency...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051872/synovial-hemangioma-of-the-knee-management-and-excellent-outcome-2-years-after-arthroscopic-synovectomy-in-a-25-year-old-male-with-a-20-year-history
#3
Akshdeep Singh Bawa, Rajnish Garg, Kaneeka Bhatnagar, Shekhar Singal
INTRODUCTION: Synovial hemangioma is a rare condition with <200 published case reports in world literature and is frequently misdiagnosed, leading to diagnostic delay of many years. This delay is even more significant if the patient comes from a rural background with a dearth of medical facilities in the area. This case had a lag of nearly 20 years from the time of onset of symptoms and the required management which is the maximum reported for any synovial hemangioma since most of them have been found and treated in adolescents...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051395/role-of-computer-tomography-and-endoscopic-ultrasonography-in-assessing-portal-and-superior-mesenteric-vessels-invasion-in-cephalo-pancreatic-adenocarcinoma
#4
Raluca Bodea, Andrada Seicean, Tudor Vasile, Tudor Calinici, Irina Ciuca, Nadim Al Hajjar, Cornel Iancu, Constantin Iordache
AIM: The aim of this study is to evaluate the information given by contrast-enhanced computer tomography (CECT) and ultrasound endoscopy (EUS) regarding vascular involvement of cephalo-pancreatic cancer, data compared with intraoperative findings. MATERIAL AND METHODS: We choose to analyze the most often interested vessels by tumor development, such as superior mesenteric artery (SMA), superior mesenteric vein (SMV) and portal vein (PV). The patients included in the study (n=425) had a cephalo-pancreatic tumor diagnosed in our Institute and a positive histology for pancreatic adenocarcinoma...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29050774/whole-genome-sequencing-of-clinical-strains-of-mycobacterium-tuberculosis-from-mumbai-india-a-potential-tool-for-determining-drug-resistance-and-strain-lineage
#5
Anirvan Chatterjee, Kayzad Nilgiriwala, Dhananjaya Saranath, Camilla Rodrigues, Nerges Mistry
Amplification of drug resistance in Mycobacterium tuberculosis (M.tb) and its transmission are significant barriers in controlling tuberculosis (TB) globally. Diagnostic inaccuracies and delays impede appropriate drug administration, which exacerbates primary and secondary drug resistance. Increasing affordability of whole genome sequencing (WGS) and exhaustive cataloguing of drug resistance mutations is poised to revolutionise TB diagnostics and facilitate personalized drug therapy. However, application of WGS for diagnostics in high endemic areas is yet to be demonstrated...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050688/no-association-between-surgical-delay-and-mortality-following-distal-femoral-fractures-a-study-from-the-danish-fracture-database-collaborators
#6
Anne Marie Nyholm, Henrik Palm, Thomas Kallemose, Anders Troelsen, Kirill Gromov
BACKGROUND: The purpose of this study was to investigate whether surgical delay or the educational level of surgeon is associated with early mortality in patients with distal femoral fractures. METHODS: 392 consecutive patients aged ≥50 years registered in the Danish Fracture Database for surgery of a non-pathological, closed, low-energy distal femoral fracture (AO33A-C) were included. Data included age, gender, American Society of Anaesthesiologists (ASA) score, type of fracture, educational level of surgeon and surgical delay...
October 10, 2017: Injury
https://www.readbyqxmd.com/read/29050355/dual-time-point-18-f-fdg-pet-ct-imaging-with-multiple-metabolic-parameters-in-the-differential-diagnosis-of-malignancy-suspected-bone-joint-lesions
#7
Chen-Tian Shen, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Xin-Yun Zhang, Quan-Yong Luo
The purpose of this study was to evaluate the diagnostic potential of dual time-point(18)F-FDG PET/CT imaging with multiple metabolic parameters in malignancy-suspected bone/joint lesions. Fifty seven consecutive patients were recruited. PET parameters including SUVmax, SUVmean, metabolic tumor volume (MTV), total lesional glycolysis (TLG) and retention indexes (RIs) were obtained. Thirty five malignant and 22 benign lesions were confirmed by pathology. In all, 48 receiver operating characteristic (ROC) curves were derived...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050189/-clinical-features-and-treatments-of-retrocorneal-fungal-infection
#8
J Cheng, H L Zhai, J Y Wang, L X Xie
Objective: To evaluate the clinical features of retrocorneal fungal infection and the therapeutic effects. Methods: This was a retrospective, noncomparative study of nine patients with retrocorneal fungal infection and an intact corneal epithelium treated at Qingdao Eye Hospital. The history, clinical features, diagnostic methods, pathogens and therapeutic effects were analyzed. Results: Five patients had a history of trauma by plant, two had a non-plant injury, and two had unidentified reasons. The duration between the initial onset and the first visit to our hospital was 7...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049993/less-limb-muscle-involvement-in-myositis-patients-with-anti-mitochondrial-antibodies
#9
Takeshi Uenaka, Hisatomo Kowa, Yoshihisa Ohtsuka, Tsuneyoshi Seki, Kenji Sekiguchi, Fumio Kanda, Tatsushi Toda
Recent studies have revealed the clinical, histological, and pathophysiological characteristics in a group of inflammatory myopathies with selected autoantibodies. We retrospectively compared the clinical manifestations and histological features between 8 anti-mitochondrial (anti-M2) antibody-positive and 33 antibody-negative patients. Patients with anti-M2 antibodies have been previously reported to have delayed diagnostic confirmation and frequent cardiopulmonary complications in comparison to those without the antibodies...
October 19, 2017: European Neurology
https://www.readbyqxmd.com/read/29048514/characteristics-and-clinical-outcome-of-lyme-neuroborreliosis-in-a-high-endemic-area-1995-2014-a-retrospective-cohort-study-in-denmark
#10
Fredrikke Christie Knudtzen, Nanna Skaarup Andersen, Thøger Gorm Jensen, Sigurdur Skarphédinsson
Background: Despite a well-described symptomatology, treatment delay and sequelae are common in patients with Lyme neuroborreliosis (LNB). The aim of this study was to contribute to the knowledge about the symptomatology and epidemiology of LNB. Methods: We conducted a retrospective study of all LNB cases verified by a positive Borrelia intrathecal antibody index test performed at the Department of Microbiology, Odense University Hospital, Denmark, from 1995 through 2014...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29048419/a-cross-sectional-quantitative-analysis-of-the-natural-history-of-farber-disease-an-ultra-orphan-condition-with-rheumatologic-and-neurological-cardinal-disease-features
#11
Matthias Zielonka, Sven F Garbade, Stefan Kölker, Georg F Hoffmann, Markus Ries
PurposeFarber disease (OMIM 22800) is an ultrarare progressive multisystemic neurodevelopmental storage disorder caused by a deficiency of the lysosomal enzyme acid ceramidase (AC). Hard clinical end points for future clinical trials remain to be defined.MethodsWe quantitatively analyzed published cases with Farber disease (N = 96). The main outcome variables were survival and diagnostic delay. As a potential predictor of survival, the influence of residual AC enzyme activity was investigated. The analysis was performed in compliance with STROBE criteria...
October 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29048096/diagnostic-delay-in-dermatitis-herpetiformis-in-a-high-prevalence-area
#12
Eriika Mansikka, Teea Salmi, Katri Kaukinen, Pekka Collin, Heini Huhtala, Timo Reunala, Kaisa Hervonen
Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease. The highest currently reported prevalence of DH is in Finland, but knowledge of diagnostic delay is limited. This study investigated the duration of rash prior to diagnosis in 446 patients with DH, analysing the results in 3 periods of 15 years. The diagnosis was considered delayed when the duration of rash before diagnosis was 2 years or longer. Factors associated with delayed diagnosis were analysed. Within the 45 years, the median duration of rash before diagnosis decreased significantly, from 12...
October 19, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29046319/effect-of-intravenous-fentanyl-on-ticagrelor-absorption-and-platelet-inhibition-among-patients-undergoing-percutaneous-coronary-intervention-the-pacify-randomized-clinical-trial
#13
John W McEvoy, Khalil Ibrahim, Thomas S Kickler, William A Clarke, Rani K Hasan, Matthew J Czarny, Ali R Keramati, Rakesh R Goli, Travis P Gratton, Jeffrey A Brinker, Matthews Chacko, Chao-Wei Hwang, Peter V Johnston, Julie M Miller, Jeffrey C Trost, William R Herzog, Roger S Blumenthal, David R Thiemann, Jon R Resar, Steven P Schulman
Fentanyl is a potent opiate commonly administered during cardiac catheterization procedures in North America. The question of whether fentanyl could have adverse consequences in patients undergoing percutaneous coronary intervention (PCI) is raised by recent research demonstrating that intravenous morphine significantly delays the absorption of oral P2Y12 platelet inhibitors. The presumed mechanism is slowed gastric emptying. The single-center Platelet Aggregation with tiCagrelor Inhibition and FentanYl (PACIFY) trial randomized adults undergoing clinically-indicated elective coronary angiography to receive the procedure with or without intravenous fentanyl (NCT02683707)...
October 18, 2017: Circulation
https://www.readbyqxmd.com/read/29045853/symptomatic-vasospasms-as-a-life-threatening-complication-after-transsphenoidal-surgery
#14
Katharina Osterhage, Patrick Czorlich, Till R Burkhardt, Roman Rotermund, Ulrich Grzyska, Jörg Flitsch
OBJECTIVE: To identify symptomatic vasospasms as a rare complication after pituitary surgery with emphasis on management and outcome. DESIGN AND METHODS: In a retrospective design, 1997 patient charts undergoing microscopic transsphenoidal surgery from 2008 till 2016 were retrospectively analyzed regarding postoperative vasospastic events, its' clinical management, and neurological outcome. RESULTS: Four patients (0.2%) were identified, who developed neurological deficits in the postoperative phase caused by proven vasospasms due to subarachnoid hemorrhage (SAH)...
October 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29043711/the-many-guises-of-endometriosis-giant-abdominal-wall-endometriosis-masquerading-as-an-incisional-hernia
#15
Chiara Petrosellini, Sala Abdalla, Tayo Oke
Endometriosis is defined by the presence of ectopic endometrial tissue outside the uterine cavity. Although it is a leading cause of chronic pelvic pain and infertility, its clinical presentation can vary, resulting in diagnostic and therapeutic challenges. Extrapelvic endometriosis is particularly difficult to diagnose owing to its ability to mimic other conditions. Endometrial tissue in a surgical scar is uncommon and often misdiagnosed as a granuloma, abscess, or malignancy. Cyclical hemorrhagic ascites due to peritoneal endometriosis is exceptionally rare...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29042871/application-of-array-comparative-genomic-hybridization-in-korean-children-under-6-years-old-with-global-developmental-delay
#16
Kyung Yeon Lee, Eunsim Shin
PURPOSE: Recent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of 27 patients with global developmental delay. METHODS: We included 27 children who fulfilled the following criteria: Korean children under 6 years with global developmental delay; children who had at least one or more physical or neurological problem other than global developmental delay; and patients in whom both array CGH and G-banded karyotyping tests were performed...
September 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29041980/comparison-of-the-clinical-effectiveness-of-us-grading-scoring-system-vs-mri-in-the-diagnosis-of-early-rheumatoid-arthritis-ra
#17
Huajun Xu, Yingchun Zhang, Huimei Zhang, Caishan Wang, Pan Mao
BACKGROUND: As an irreversible disease, a treatment delay can negatively affect treatment response in rheumatoid arthritis (RA). Ultrasound and MRI have played an important role in assessing disease progression and response to treatment in RA for many years. The present study was designed to compare the diagnostic efficacy of ultrasound grading and MRI in early RA. METHODS: In this retrospective study, 62 early RA patients within 12 months of symptom onset were included...
October 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29039828/-clinical-laboratory-and-instrumental-criteria-for-myocarditis-established-in-comparison-with-myocardial-biopsy-a-non-invasive-diagnostic-algorithm
#18
O V Blagova, Yu V Osipova, A V Nedostup, E A Kogan, V A Sulimov
AIM: To determine the diagnostic value of different clinical, laboratory, and instrumental signs in the diagnosis of myocarditis in patients with the picture of idiopathic arrhythmias, dilated cardiomyopathy (DCM) and in a comparison group when comparing with myocardial morphological examination. SUBJECTS AND METHODS: A study group included 100 patients (35 women; mean age, 44.7±12.5 years) with idiopathic arrhythmias (n=20) and DCM as a syndrome (n=100). All underwent myocardial morphological examination: endomyocardial biopsy (EMB) (n=71), intraoperative biopsy (n=13), study of the explanted heart (n=6), and autopsy (n=11)...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29039368/connecting-parents-to-a-pediatric-emergency-department-designing-a-mobile-app-based-on-patient-centred-care-principles
#19
Frederic Ehrler, Johan N Siebert, Jessica Rochat, Franck Schneider, Annick Galetto, Alain Gervaix, Christian Lovis
INTRODUCTION: Patient centred care fosters a holistic approach of care switching the focus from a disease perspective to a patient's experience perspective. Patient centred care is of particular importance in the context of paediatric emergency medicine. Indeed, parents entering a paediatric emergency department (PED) are usually under stress caused by their children's illness, the unfamiliar setting of the PED and delays of care. All these factors can deteriorate their experience as well as the relationships between healthcare providers, the patients and their parents...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29038856/comparison-of-diagnostic-performance-between-1-millisievert-ct-enterography-and-half-standard-dose-ct-enterography-for-evaluating-active-inflammation-in-patients-with-crohn-s-disease
#20
Jung Hee Son, Seung Ho Kim, Een Young Cho, Kyeong Hwa Ryu
PURPOSE: To compare the diagnostic performance of CT enterography (CTE) images obtained at 1 millisievert (mSv) and reconstructed with filtered back projection (FBP) and adaptive statistical iterative reconstruction (ASIR) with those of half-dose CTE images for the evaluation of active inflammation in patients with Crohn's disease. METHODS: Forty-six consecutive patients (mean age 29 years; range 15-59 years) with Crohn's disease underwent CTE which comprised a standard-dose scan at the enteric phase (45 s), a half-dose scan with ASIR at the portal venous phase (70 s), and 1 mSv scans with FBP and ASIR at the delayed phase (90 s) under a fixed 120 kVp and variable mAs...
October 16, 2017: Abdominal Radiology
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