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https://www.readbyqxmd.com/read/29138654/syphilis-and-hiv-infections-among-pregnant-women-attending-antenatal-clinics-in-republic-of-congo
#1
Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Methods: A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29074839/acute-onset-vascular-dementia-with-bi-thalamic-infarct-in-an-hiv-positive-subject
#2
Léonard Kouamé Kouassi, Mariam Doumbia-Ouattara
BACKGROUND Bi-thalamic infarctions are rare and marked by clinical polymorphism. Their association with HIV has never been reported. CASE REPORT We report a 51-year-old right-handed man with no medical history, who presented an acute onset vascular dementia associated with an antero-retrograde amnesia, a word-finding difficulty, and a dysexecutive syndrome. The CT scan was normal. Brain MRI revealed a paramedian and bi-thalamic infarction, evoking an occlusion of the Percheron artery. The electrocardiogram, transthoracic and transesophageal cardiac ultrasound, and Doppler echo of cervical arteries gave normal results...
October 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29063514/biomarkers-of-neuronal-injury-and-amyloid-metabolism-in-the-cerebrospinal-fluid-of-patients-infected-with-hiv-1-subtypes-b-and-c
#3
Sérgio Monteiro de Almeida, Clea E Ribeiro, Indianara Rotta, Mauro Piovesan, Bin Tang, Florin Vaida, Sonia Mara Raboni, Scott Letendre, Michael Potter, Meire S Batistela Fernandes, Ronald J Ellis
Based on prior reports that the HIV-1 Tat protein modulates amyloid-beta (Aβ) metabolism, this study aimed to compare CSF neural injury biomarkers between 27 patients with HIV subtype B, 26 patients with HIV subtype C, 18 healthy HIV-negative controls, and 24 patients with Alzheimer's disease (AD). Immunoassays were used to measure soluble amyloid precursor protein α and β (sAPPα, sAPPβ), Aβ oligomers 38, 40, 42, and Aβ-total; phosphorylated tau (P-tau181), and total tau (T-tau). Comparisons between HIV(+) and HIV(-) (including AD) were adjusted by linear regression for gender and age; HIV subtype comparisons were adjusted for nadir CD4 and plasma viral load suppression...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29045464/tip60-represses-telomerase-expression-by-inhibiting-sp1-binding-to-the-tert-promoter
#4
Deepa Rajagopalan, Amit Kumar Pandey, Magdalene Claire Xiuzhen, Kwok Kin Lee, Shainan Hora, Yanzhou Zhang, Boon Haow Chua, Hui Si Kwok, Shreshtha Sailesh Bhatia, Lih Wen Deng, Daniel G Tenen, Dennis Kappei, Sudhakar Jha
HIV1-TAT interactive protein (TIP60) is a haploinsufficient tumor suppressor. However, the potential mechanisms endowing its tumor suppressor ability remain incompletely understood. It plays a vital role in virus-induced cancers where TIP60 down-regulates the expression of human papillomavirus (HPV) oncoprotein E6 which in turn destabilizes TIP60. This intrigued us to identify the role of TIP60, in the context of a viral infection, where it is targeted by oncoproteins. Through an array of molecular biology techniques such as Chromatin immunoprecipitation, expression analysis and mass spectrometry, we establish the hitherto unknown role of TIP60 in repressing the expression of the catalytic subunit of the human telomerase complex, TERT, a key driver for immortalization...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29021107/marijuana-use-and-hiv-treatment-outcomes-among-pwh-receiving-care-at-an-urban-hiv-clinic
#5
Sagarika Sinha, Mary E McCaul, Heidi E Hutton, Anne K Monroe, Anika Alvanzo, Catherine Lesko, Bryan Lau, Jeanne Keruly, Richard D Moore, Geetanjali Chander
BACKGROUND: While marijuana use is prevalent among persons with HIV (PWH), few studies have examined the relationship between marijuana use and HIV treatment outcomes independent of alcohol and other drug use. METHODS: We conducted a prospective cohort study to examine the relationships between frequency of marijuana use and antiretroviral therapy (ART) adherence and viral suppression in patients enrolled in the Johns Hopkins HIV Clinical Cohort between September 2013 through November 2015 (N=1377)...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28985062/nucleofuge-generating-glycosidations-by-the-remote-activation-of-hydroxybenzotriazolyl-glycosides
#6
Mahesh Neralkar, Bijoyananda Mishra, Srinivas Hotha
Hydroxybenzotriazole is routinely used in peptide chemistry for reducing racemization due to the increased reactivity. In this article, very stable hydroxybenzotriazolyl glucosides were identified to undergo glycosidation. The reaction was hypothesized to go through the remote activation by the Tf2O at the N3-site of HOBt followed by the extrusion of the oxocarbenium ion that was attacked by the glycosyl acceptor. Further, equilibration of the zwitterionic benzotriazolyl species makes the leaving group noncompetitive and generates the nucleofuge that has been reconverted to the glycosyl donor...
October 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28924485/hypogonadotropic-hypogonadism-in-human-immunodeficiency-virus-infected-men-uncommonly-low-testosterone-levels
#7
Ana Coelho Gomes, José Maria Aragüés, Sílvia Guerra, Joana Fernandes, Mário Rui Mascarenhas
Hypogonadotropic hypogonadism (HH) is common and occurs prematurely in HIV-infected men. However, HH with very low testosterone has not been described. Three men with normal pubertal development and HIV1 diagnosis at the ages of 22, 34 and 35 years. All complained of decreased libido, anejaculation and erectile dysfunction thirteen years, six months and one year after HIV diagnosis, respectively. Two had depressive syndrome and two were treated with antiretroviral therapy. Laboratory tests revealed isolated HH in all...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28867257/oropharyngeal-candidiasis-prevalence-among-hiv-infected-patients-at-the-teaching-hospital-of-treichville-abidjan-c%C3%A3-te-d-ivoire
#8
A Konaté, P C M Barro-Kiki, K F Kassi, K E Angora, H Vanga-Bosson, V Djohan, A V Bédia-Tanoh, A J S Miézan, W Yavo, E I H Menan
AIM OF THE STUDY: The aim of this study was to determine the mycological profile of oropharyngeal candidiasis among HIV-infected patients from Internal Medicine, Infectious and Tropical Diseases, and Pneumo-Phthisiology Diseases departments of the Teaching Hospital of Treichville in Abidjan, Côte d'Ivoire. PATIENTS AND METHODS: This was a cross-sectional study carried out on patients with lesions suggestive of oropharyngeal candidiasis from October 2010 to April 2011...
August 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28843384/staging-of-recent-hiv-1-infection-using-geenius-rapid-confirmatory-assay-compared-to-inno-lia-new-lav-and-blot-2-2-assays
#9
E Tuaillon, A Sanosyan, A Pisoni, J Liscouët, A Makinson, P Van de Perre
BACKGROUND: Besides confirmation of HIV seropositivity, Western Blot (WB) assays play an important role for identification of recent infection based on incomplete antibody reactivity and lack of p31 band. OBJECTIVES: We evaluated the capacities of the Geenius™ HIV1/2 Confirmatory Assay (Bio-Rad), a new generation rapid confirmatory assay based on immune-chromatography and automated reading, for staging of HIV-1 infection. STUDY DESIGN: Sixteen samples collected during early HIV-1 infections (Fiebig stage III-VI) were tested using the Geenius assay, and compared to HIV Blot 2...
August 18, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28835532/sensitivity-of-the-stat-view-rapid-self-test-and-implications-for-use-during-acute-hiv-infection
#10
Narjis Boukli, Anders Boyd, Noémie Wendremaire, Pierre-Marie Girard, Julie Bottero, Laurence Morand-Joubert
OBJECTIVES: HIV testing is an important step towards diminishing incident infections. Rapid self-tests whose use is becoming more common in France could help increase access to testing, yet could fail to diagnose HIV during acute HIV infection (AHI). The aim of the present study was to evaluate HIV-detection sensitivity of a commonly used rapid self-test (STAT-VIEW HIV1/2), compared with another point-of-care rapid test (INSTI), among patients presenting with AHI. METHODS: Individuals tested at Saint-Antoine Hospital (Paris, France) with negative or indeterminate western blot (WB) results and detectable HIV-RNA were included...
August 23, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28816863/management-of-retinoblastoma-with-hiv-seropositivity
#11
Abhinav Dhami, Anita Ramesh, Vikas Khetan
PURPOSE: To report a case of retinoblastoma with concomitant association with HIV seropositivity and its management. METHODS: A retrospective case report of a 3-year-old male child presenting with right eye Group B and left eye Group E retinoblastoma with simultaneous positivity for HIV1 antibody. The parents were also tested positive for HIV and were referred for initiating antiretroviral therapy. RESULTS: The child was managed with focal laser therapy for the right eye and six cycles of systemic chemotherapy, and the left eye was planned for enucleation with ball implant...
August 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28811543/4-e-p-tolylimino-methylbenzene-1-2-diol-timbd-suppresses-hiv1-gp120-mediated-production-of-il6-and-il8-but-not-ccl5
#12
Fatma Abdalla, Anantha Nookala, Subhash B Padhye, Anil Kumar, Hari K Bhat
Human immunodeficiency virus (HIV) has been associated with inflammatory effects that may potentially result in neurodegenerative changes and a number of newer chemotherapeutic agents are being tested to ameliorate these effects. In this study, we investigated the anti-neuroinflammatory activity of a novel resveratrol analog 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol} (TIMBD) against HIV1-gp120 induced neuroinflammation in SVG astrocytes. SVG astrocytic cells were pretreated with TIMBD or resveratrol (RES) and then transfected with a plasmid encoding HIV1-gp120...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764661/hiv-testing-week-2015-lowering-barriers-for-hiv-testing-among-high-risk-groups-in-amsterdam
#13
M Bartelsman, I K Joore, J E van Bergen, A A Hogewoning, F R Zuure, M G van Veen
BACKGROUND: Evaluation of the HIV Testing Week (HTW) 2015 in Amsterdam: the number of (positive) tested persons, characteristics and testing history of the tested population, the differences in attendance per location and the healthcare workers' experiences and opinions concerning the HTW. METHODS: The HTW took place from 28 November till 4 December 2015. Anonymous HIV rapid testing (INSTI™ HIV1/HIV2 Ab test or Determine™ HIV-1/2 Ag/Ab test) was offered free of charge at four hospitals, 12 general practitioner (GP) clinics, a sexually transmitted infections (STI) clinic, a laboratory, sites of a community-based organisation, and at outreach locations...
August 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28666370/assessment-of-hiv-screening-tests-for-use-in-preexposure-prophylaxis-programs
#14
Constance Delaugerre, Guillemette Antoni, Nadia Mahjoub, Gilles Pialoux, Eric Cua, Armelle Pasquet, Nolwenn Hall, Cécile Tremblay, Laurent Cotte, Catherine Capitant, Marie-Laure Chaix, Laurence Meyer, Jean-Michel Molina
Preexposure prophylaxis programs involve frequent human immunodeficiency virus (HIV) testing. We evaluated the sensitivity of 2 antigen/antibody immunoassays (Architect and Bioplex), 2 antibody-based rapid tests (Vikia-HIV-1/2 and Autotest-VIH), and 1 antigen/antibody rapid test (Alere HIV Combo) for the diagnosis of HIV infection. Among the 31 HIV-1-infected participants in the ANRS-IPERGAY trial, HIV-1 RNA was detected alone in only 2. The sensitivities of the Architect and Bioplex assays were 83% (95% confidence interval [CI], 76%-99%) and 82% (95% CI, 63%-94%), respectively...
August 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28623553/kaposi-s-disease-in-an-hiv-positive-child-with-probable-contamination-from-his-grandmother
#15
A Dicko, Y Fofana, A Traoré, S Berthé, S Touré, C Lamissa, B Guindo, A Keita, O Faye
Kaposi's disease in children with HIV is rarely reported in everyday practice. This is a case study of cutaneous Kaposi's disease revealing HIV in a 5-year-old child with polymorphic eruption of papules and nodules on the face, trunk, back, and limbs. Histopathological examination confirmed the diagnosis of Kaposi's disease. The child's HIV serology was positive with a CD4 count of 240/mm(3), normochromic and normocytic anemia, and a hemoglobin level at 8.5 g/dl. It was found that the child, after early weaning from his HIV-negative mother, had repeatedly suckled his healthy grandmother, who had no skin lesions but was HIV1 positive...
October 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28614778/the-human-immunodeficiency-virus-hiv1-protease-inhibitor-sanquinavir-activates-autophagy-and-removes-lipids-deposited-in-lipid-droplets
#16
A Polus, M Bociaga-Jasik, U Czech, J Goralska, U Cialowicz, M Chojnacka, M Polus, K Jurowski, A Dembinska-Kiec
Reduction in mortality and increased average life span of the human immunodeficiency virus (HIV)-infected patients treated with antiretroviral therapy (ART) are associated with the risk of unwanted effects, such as insulin resistance and dyslipidemia with cardiovascular complications. Antiretroviral therapy may also be associated with lipodystrophy characterized as peripheral lipoatrophy with central fat accumulation. Understanding the molecular mechanisms of lipodystrophy caused by ART is important for therapeutic strategy and the prediction of side-effects...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28602196/sequence-specific-recognition-of-hiv-1-dsdna-in-the-large-amount-of-normal-dsdna-based-upon-nicking-enzyme-signal-amplification-and-triplex-dna
#17
Houya Zhu, Manjun Zhang, Li Zou, Ruimin Li, Liansheng Ling
A sensitive fluorescent strategy for sequence specific recognition of HIV dsDNA was established based upon Nicking Enzyme Signal Amplification (NESA) and triplex formation. dsDNA sequence from the site 7960 to site 7991 of the HIV1 dsDNA gene was designed as target dsDNA, which was composed of two complementary strands Oligonucleotide 1 with the sequence of 3'-CTT CCT TAT CTT CTT CTT CCA CCT CTC TCT CT-5' (Oligo-1) and Oligonucleotide 2 with the sequence of 5'-GAA GGA ATA GAA GAA GAA GGT GGA GAG AGA GA-3' (Oligo-2)...
October 1, 2017: Talanta
https://www.readbyqxmd.com/read/28584850/a-subset-of-extreme-human-immunodeficiency-virus-hiv-controllers-is-characterized-by-a-small-hiv-blood-reservoir-and-a-weak-t-cell-activation-level
#18
Etienne Canouï, Camille Lécuroux, Véronique Avettand-Fenoël, Marine Gousset, Christine Rouzioux, Asier Saez-Cirion, Laurence Meyer, Faroudy Boufassa, Olivier Lambotte, Nicolas Noël
BACKGROUND: Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load. PATIENTS AND METHODS: The HICs with undetectable viral load ([uHICs] ie, for whom a viral load had never been detected with routine assays; n = 52) were compared with 178 HICs with blips during the follow up (bHICs). Clinical characteristics, ultrasensitive HIV-ribonucleic acid (RNA) and HIV-deoxyribonucleic acid (DNA) loads, HIV1-Western blot profiles, and immune parameters were analyzed...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28486519/changes-in-body-mass-index-and-hemoglobin-concentration-in-breastfeeding-women-living-with-hiv-with-a-cd4-count-over-350-results-from-4-african-countries-the-anrs-12174-trial
#19
Eric Nagaonlé Somé, Ingunn M S Engebretsen, Nicolas Nagot, Nicolas Y Meda, Roselyne Vallo, Chipepo Kankasa, James K Tumwine, Mandisa Singata, Justus G Hofmeyr, Philippe Van de Perre, Thorkild Tylleskär
INTRODUCTION: Breastfeeding is recommended for infants born to HIV-infected women in low-income settings. Both breastfeeding and HIV-infection are energy demanding. Our objective was to explore how exclusive and predominant breastfeeding changes body mass index (BMI) among breastfeeding HIV1-positive women participating in the ANRS12174 trial (clinical trial no NCT0064026). METHODS: HIV-positive women (n = 1 267) with CD4 count >350, intending to breastfeed HIV-negative infants were enrolled from Burkina Faso, South Africa, Uganda and Zambia and counselled on breastfeeding...
2017: PloS One
https://www.readbyqxmd.com/read/28472379/two-ribosome-recruitment-sites-direct-multiple-translation-events-within-hiv1-gag-open-reading-frame
#20
Jules Deforges, Sylvain de Breyne, Melissa Ameur, Nathalie Ulryck, Nathalie Chamond, Afaf Saaidi, Yann Ponty, Theophile Ohlmann, Bruno Sargueil
No abstract text is available yet for this article.
July 7, 2017: Nucleic Acids Research
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