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https://www.readbyqxmd.com/read/29337418/specific-non-covalent-interactions-determine-optimal-structure-of-a-buried-ligand-moiety-qm-mm-and-pure-qm-modeling-of-complexes-of-the-small-molecule-cd4-mimetics-and-hiv1-gp120
#1
Francesca Moraca, David Rinaldo, Amos Brittain Smith, Cameron Abrams
The small molecule CD4 mimetics (smCD4mc) are a class of highly potent HIV-1 entry inhibitors characterized by a unique SAR. They share a halogenated phenyl ring (region 1) that deeply inserts into an otherwise water-filled cavity at the CD4 binding site on the gp120 surface, so-called F43 cavity. Conservative modifications to region 1 away from this halogenated phenyl motif have all lead to loss of activity, despite they are predicted to bind equally well via standard empirical computational approaches making difficult to further optimize this region of the compounds to increase binding to gp120...
January 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29286218/seroepidemiological-study-of-hepatitis-b-c-and-hiv-among-blood-donors-in-kerman
#2
Majid Mohsenizadeh, Hamid Reza Mollaei, Motahareh Ghaziizadeh
Background: Infections transmitted through blood transfusions are the most important issue associated with blood donation. We aimed to provide an assessment of the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kerman province of Iran. Methods: Between 2014-2016, 99,187 samples were examined in a retrospective study in five blood transfusion centers in Kerman province. Serologic screening for HBsAg, anti-HCV and anti-HIV1/2 was conducted for all samples and positive cases were confirmed...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29273432/the-alpha-helix-1-from-the-first-conserved-region-of-hiv1-gp120-is-reconstructed-in-the-short-nq21-peptide
#3
Vladislav Victorovich Khrustalev, Tatyana Aleksandrovna Khrustaleva, Ekaterina Yurievna Kahanouskaya, Yulia Anatolyevna Rudnichenko, Hanna Vitalyevna Bandarenka, Alexander Migranovich Arutyunyan, Kseniya Victorovna Girel, Nadia Vladimirovna Khinevich, Alexander Leonidovich Ksenofontov, Larisa Valentinovna Kordyukova
Investigations of short peptides that can be used in the next phase of synthetic HIV1 vaccine development are an urgent goal, as well as investigations of peptides that can be used in immunological tests with the aim to check the titer of antibodies against the alpha helix 1 from the first conserved region of HIV1 gp120 that are known to cause antibody-dependent cellular cytotoxicity (ADCC). The aim of this work was to study the structure of the NQ21 peptide corresponding to the less mutable part of the first conserved region of HIV1 gp120 (residues 94-114)...
December 19, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29243825/dermatologic-manifestations-among-human-immunodeficiency-virus-patients-in-morocco-and-association-with-immune-status
#4
Hicham Titou, Christelle Ebongo, Naoufal Hjira
OBJECTIVE: The objective was to determine if the type and number of skin diseases can be clinical indicators of underlying immune status in HIV1 disease by estimating and correlating with the CD4 count and CDC stage. MATERIALS AND METHODS: This was a retrospective cross-sectional descriptive study. All consecutive patients infected with HIV1 followed at the Dermatology Department of Rabat Military Hospital between January 2008 and January 2017 were studied for dermatological manifestations, CD4 count and CDC clinical stage...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29161993/burden-of-asymptomatic-malaria-anemia-and-relationship-with-cotrimoxazole-use-and-cd4-cell-count-among-hiv1-infected-adults-living-in-gabon-central-africa
#5
Marielle Karine Bouyou Akotet, Jeanne Vanessa Koumba Lengongo, Magloire Ondounda, Eric Kendjo, Arnaud Mongo Delis, Magalie Essomeyo Mebale, Jacques Mari Ndong Ngomo, Noé Patrick M Bondoukwe, Denise Patricia Mawili-Mboumba, Madeleine Okome Nkoumou
 Objective : This study determined the prevalence of asymptomatic Plasmodium (P.) falciparum infection and anemia in adults living with HIV/AIDS (PLHIV) and compared malaria prevalence between 858 HIV-infected (PLHIV) and 272 uninfected individuals in Gabon where such information are lacking. Factors influencing malaria and anemia were also investigated. PATIENTS AND METHODS: Participants were screened for malaria. Available hemoglobin level, socio-demographic and use of prevention or treatment data were compared between both groups...
November 21, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/29158866/-tb-hiv-co-infection-associated-with-kaposi-s-sarcoma-under-opioid-substitution-treatment-using-methadone-about-a-case
#6
Viviane Marie Pierre Cisse Diallo, Louise Fortes Deguenonvo, Khardiata Diallo Mbaye, Daye Ka, Ndeye Aissatou Lakhe, Ibrahima Ndiaye, Daouda Thioub, Sylvie Audrey Diop Nyafouna, Aminata Massaly, Alassane Dièye, Moustapha Diop, Cheikh Tidiane Ndour, Moussa Seydi
Late diagnosis of HIV infection can be fatal because it favors the appearance of opportunistic infections whose management requires the use of several molecules which can cause drug interactions. We report the case of a 45-year old female patient under heroin substitution treatment, using methadone and with HIV1 under antiretroviral treatment. This patient had nonspecific pulmonary appearance associated with dry nagging cough and progressive dyspnea evolving in a feverish context. Moreover, clinical examination showed left lower limb lymphedema with painless angiomatous nodules evolving over three years associated with plaques, angiomatous nodules occurred more recently at the level of the anterior face of the thorax...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29138654/syphilis-and-hiv-infections-among-pregnant-women-attending-antenatal-clinics-in-republic-of-congo
#7
Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Methods: A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29074839/acute-onset-vascular-dementia-with-bi-thalamic-infarct-in-an-hiv-positive-subject
#8
Léonard Kouamé Kouassi, Mariam Doumbia-Ouattara
BACKGROUND Bi-thalamic infarctions are rare and marked by clinical polymorphism. Their association with HIV has never been reported. CASE REPORT We report a 51-year-old right-handed man with no medical history, who presented an acute onset vascular dementia associated with an antero-retrograde amnesia, a word-finding difficulty, and a dysexecutive syndrome. The CT scan was normal. Brain MRI revealed a paramedian and bi-thalamic infarction, evoking an occlusion of the Percheron artery. The electrocardiogram, transthoracic and transesophageal cardiac ultrasound, and Doppler echo of cervical arteries gave normal results...
October 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29063514/biomarkers-of-neuronal-injury-and-amyloid-metabolism-in-the-cerebrospinal-fluid-of-patients-infected-with-hiv-1-subtypes-b-and-c
#9
Sérgio Monteiro de Almeida, Clea E Ribeiro, Indianara Rotta, Mauro Piovesan, Bin Tang, Florin Vaida, Sonia Mara Raboni, Scott Letendre, Michael Potter, Meire S Batistela Fernandes, Ronald J Ellis
Based on prior reports that the HIV-1 Tat protein modulates amyloid-beta (Aβ) metabolism, this study aimed to compare CSF neural injury biomarkers between 27 patients with HIV subtype B, 26 patients with HIV subtype C, 18 healthy HIV-negative controls, and 24 patients with Alzheimer's disease (AD). Immunoassays were used to measure soluble amyloid precursor protein α and β (sAPPα, sAPPβ), Aβ oligomers 38, 40, 42, and Aβ-total; phosphorylated tau (P-tau181), and total tau (T-tau). Comparisons between HIV(+) and HIV(-) (including AD) were adjusted by linear regression for gender and age; HIV subtype comparisons were adjusted for nadir CD4 and plasma viral load suppression...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29045464/tip60-represses-telomerase-expression-by-inhibiting-sp1-binding-to-the-tert-promoter
#10
Deepa Rajagopalan, Amit Kumar Pandey, Magdalene Claire Xiuzhen, Kwok Kin Lee, Shainan Hora, Yanzhou Zhang, Boon Haow Chua, Hui Si Kwok, Shreshtha Sailesh Bhatia, Lih Wen Deng, Daniel G Tenen, Dennis Kappei, Sudhakar Jha
HIV1-TAT interactive protein (TIP60) is a haploinsufficient tumor suppressor. However, the potential mechanisms endowing its tumor suppressor ability remain incompletely understood. It plays a vital role in virus-induced cancers where TIP60 down-regulates the expression of human papillomavirus (HPV) oncoprotein E6 which in turn destabilizes TIP60. This intrigued us to identify the role of TIP60, in the context of a viral infection, where it is targeted by oncoproteins. Through an array of molecular biology techniques such as Chromatin immunoprecipitation, expression analysis and mass spectrometry, we establish the hitherto unknown role of TIP60 in repressing the expression of the catalytic subunit of the human telomerase complex, TERT, a key driver for immortalization...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29021107/marijuana-use-and-hiv-treatment-outcomes-among-pwh-receiving-care-at-an-urban-hiv-clinic
#11
Sagarika Sinha, Mary E McCaul, Heidi E Hutton, Anne K Monroe, Anika Alvanzo, Catherine Lesko, Bryan Lau, Jeanne Keruly, Richard D Moore, Geetanjali Chander
BACKGROUND: While marijuana use is prevalent among persons with HIV (PWH), few studies have examined the relationship between marijuana use and HIV treatment outcomes independent of alcohol and other drug use. METHODS: We conducted a prospective cohort study to examine the relationships between frequency of marijuana use and antiretroviral therapy (ART) adherence and viral suppression in patients enrolled in the Johns Hopkins HIV Clinical Cohort between September 2013 through November 2015 (N=1377)...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28985062/nucleofuge-generating-glycosidations-by-the-remote-activation-of-hydroxybenzotriazolyl-glycosides
#12
Mahesh Neralkar, Bijoyananda Mishra, Srinivas Hotha
Hydroxybenzotriazole is routinely used in peptide chemistry for reducing racemization due to the increased reactivity. In this article, very stable hydroxybenzotriazolyl glucosides were identified to undergo glycosidation. The reaction was hypothesized to go through the remote activation by the Tf2O at the N3-site of HOBt followed by the extrusion of the oxocarbenium ion that was attacked by the glycosyl acceptor. Further, equilibration of the zwitterionic benzotriazolyl species makes the leaving group noncompetitive and generates the nucleofuge that has been reconverted to the glycosyl donor...
October 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28924485/hypogonadotropic-hypogonadism-in-human-immunodeficiency-virus-infected-men-uncommonly-low-testosterone-levels
#13
Ana Coelho Gomes, José Maria Aragüés, Sílvia Guerra, Joana Fernandes, Mário Rui Mascarenhas
Hypogonadotropic hypogonadism (HH) is common and occurs prematurely in HIV-infected men. However, HH with very low testosterone has not been described. Three men with normal pubertal development and HIV1 diagnosis at the ages of 22, 34 and 35 years. All complained of decreased libido, anejaculation and erectile dysfunction thirteen years, six months and one year after HIV diagnosis, respectively. Two had depressive syndrome and two were treated with antiretroviral therapy. Laboratory tests revealed isolated HH in all...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28867257/oropharyngeal-candidiasis-prevalence-among-hiv-infected-patients-at-the-teaching-hospital-of-treichville-abidjan-c%C3%A3-te-d-ivoire
#14
A Konaté, P C M Barro-Kiki, K F Kassi, K E Angora, H Vanga-Bosson, V Djohan, A V Bédia-Tanoh, A J S Miézan, W Yavo, E I H Menan
AIM OF THE STUDY: The aim of this study was to determine the mycological profile of oropharyngeal candidiasis among HIV-infected patients from Internal Medicine, Infectious and Tropical Diseases, and Pneumo-Phthisiology Diseases departments of the Teaching Hospital of Treichville in Abidjan, Côte d'Ivoire. PATIENTS AND METHODS: This was a cross-sectional study carried out on patients with lesions suggestive of oropharyngeal candidiasis from October 2010 to April 2011...
August 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28843384/staging-of-recent-hiv-1-infection-using-geenius-rapid-confirmatory-assay-compared-to-inno-lia-new-lav-and-blot-2-2-assays
#15
E Tuaillon, A Sanosyan, A Pisoni, J Liscouët, A Makinson, P Van de Perre
BACKGROUND: Besides confirmation of HIV seropositivity, Western Blot (WB) assays play an important role for identification of recent infection based on incomplete antibody reactivity and lack of p31 band. OBJECTIVES: We evaluated the capacities of the Geenius™ HIV1/2 Confirmatory Assay (Bio-Rad), a new generation rapid confirmatory assay based on immune-chromatography and automated reading, for staging of HIV-1 infection. STUDY DESIGN: Sixteen samples collected during early HIV-1 infections (Fiebig stage III-VI) were tested using the Geenius assay, and compared to HIV Blot 2...
August 18, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28835532/sensitivity-of-the-stat-view-rapid-self-test-and-implications-for-use-during-acute-hiv-infection
#16
Narjis Boukli, Anders Boyd, Noémie Wendremaire, Pierre-Marie Girard, Julie Bottero, Laurence Morand-Joubert
OBJECTIVES: HIV testing is an important step towards diminishing incident infections. Rapid self-tests whose use is becoming more common in France could help increase access to testing, yet could fail to diagnose HIV during acute HIV infection (AHI). The aim of the present study was to evaluate HIV-detection sensitivity of a commonly used rapid self-test (STAT-VIEW HIV1/2), compared with another point-of-care rapid test (INSTI), among patients presenting with AHI. METHODS: Individuals tested at Saint-Antoine Hospital (Paris, France) with negative or indeterminate western blot (WB) results and detectable HIV-RNA were included...
August 23, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28816863/management-of-retinoblastoma-with-hiv-seropositivity
#17
Abhinav Dhami, Anita Ramesh, Vikas Khetan
PURPOSE: To report a case of retinoblastoma with concomitant association with HIV seropositivity and its management. METHODS: A retrospective case report of a 3-year-old male child presenting with right eye Group B and left eye Group E retinoblastoma with simultaneous positivity for HIV1 antibody. The parents were also tested positive for HIV and were referred for initiating antiretroviral therapy. RESULTS: The child was managed with focal laser therapy for the right eye and six cycles of systemic chemotherapy, and the left eye was planned for enucleation with ball implant...
August 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28811543/4-e-p-tolylimino-methylbenzene-1-2-diol-timbd-suppresses-hiv1-gp120-mediated-production-of-il6-and-il8-but-not-ccl5
#18
Fatma Abdalla, Anantha Nookala, Subhash B Padhye, Anil Kumar, Hari K Bhat
Human immunodeficiency virus (HIV) has been associated with inflammatory effects that may potentially result in neurodegenerative changes and a number of newer chemotherapeutic agents are being tested to ameliorate these effects. In this study, we investigated the anti-neuroinflammatory activity of a novel resveratrol analog 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol} (TIMBD) against HIV1-gp120 induced neuroinflammation in SVG astrocytes. SVG astrocytic cells were pretreated with TIMBD or resveratrol (RES) and then transfected with a plasmid encoding HIV1-gp120...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764661/hiv-testing-week-2015-lowering-barriers-for-hiv-testing-among-high-risk-groups-in-amsterdam
#19
M Bartelsman, I K Joore, J E van Bergen, A A Hogewoning, F R Zuure, M G van Veen
BACKGROUND: Evaluation of the HIV Testing Week (HTW) 2015 in Amsterdam: the number of (positive) tested persons, characteristics and testing history of the tested population, the differences in attendance per location and the healthcare workers' experiences and opinions concerning the HTW. METHODS: The HTW took place from 28 November till 4 December 2015. Anonymous HIV rapid testing (INSTI™ HIV1/HIV2 Ab test or Determine™ HIV-1/2 Ag/Ab test) was offered free of charge at four hospitals, 12 general practitioner (GP) clinics, a sexually transmitted infections (STI) clinic, a laboratory, sites of a community-based organisation, and at outreach locations...
August 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28666370/assessment-of-hiv-screening-tests-for-use-in-preexposure-prophylaxis-programs
#20
Constance Delaugerre, Guillemette Antoni, Nadia Mahjoub, Gilles Pialoux, Eric Cua, Armelle Pasquet, Nolwenn Hall, Cécile Tremblay, Laurent Cotte, Catherine Capitant, Marie-Laure Chaix, Laurence Meyer, Jean-Michel Molina
Preexposure prophylaxis programs involve frequent human immunodeficiency virus (HIV) testing. We evaluated the sensitivity of 2 antigen/antibody immunoassays (Architect and Bioplex), 2 antibody-based rapid tests (Vikia-HIV-1/2 and Autotest-VIH), and 1 antigen/antibody rapid test (Alere HIV Combo) for the diagnosis of HIV infection. Among the 31 HIV-1-infected participants in the ANRS-IPERGAY trial, HIV-1 RNA was detected alone in only 2. The sensitivities of the Architect and Bioplex assays were 83% (95% confidence interval [CI], 76%-99%) and 82% (95% CI, 63%-94%), respectively...
August 1, 2017: Journal of Infectious Diseases
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