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https://www.readbyqxmd.com/read/29243959/application-of-glycemic-variability-percentage-implications-for-continuous-glucose-monitor-utilization-and-analysis-of-artificial-pancreas-data
#1
Arturo Garcia, Andrew K Balo, Bruce A Buckingham, Irl B Hirsch, Thomas A Peyser
BACKGROUND: The problem of glycemic variability has been widely acknowledged in patients with diabetes with severe insulin deficiency. In a companion article, we proposed a novel metric, the glycemic variability percentage (GVP), for assessing glycemic variability that accounts for both the amplitude and frequency of glycemic fluctuations. METHOD: We applied the new metric, the GVP, to a previously reported case of a subject using an earlier generation continuous glucose monitoring (CGM) device, in which successive periods of use were associated with an apparent decrease in glycemic variability...
December 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29243894/indications-for-and-outcomes-of-liver-transplantation-in-patients-with-alcohol-associated-liver-disease-aud
#2
Paulina K Phillips, Matthew W Caldis, Alexander D Hristov, Alexander S Lee, Michael R Lucey
The manufacture and consumption of alcohol are ubiquitous and as old as time. Alcohol use disorder (AUD) is defined as a problematic pattern of alcohol use leading to clinically significant impairment. The physical injuries that result from excessive alcohol consumption are varied including end-organ damage to liver (alcohol-associated liver disease or ALD), pancreas, brain and heart, and systemic consequences including several forms of cancer. Liver transplantation (LT) remains the treatment of last resort for life-threatening liver disease...
December 14, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29243502/evidence-based-management-of-incidental-focal-uptake-of-fluorodeoxyglucose-on-pet-ct
#3
Deborah Pencharz, Malavika Nathan, Thomas L Wagner
Focal incidental uptake, with or without CT abnormalities, is a common finding on FDG PET/CT and evidence based management for this type of uptake is lacking. This article reviews the evidence on focal incidental uptake including the incidence of malignancy, differential diagnosis and imaging criteria which can be used to further characterise it. The article focusses on PET rather than CT criteria. The strength of the evidence base is highly variable ranging from systematic reviews and meta-analyses to a virtual absence of evidence...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29242734/images-from-18f-dopa-scan-in-congenital-hyperinsulinism-not-always-a-clue-for-diagnosis
#4
Evelina Maines, Luca Giacomello, Mirko D'Onofrio, Matteo Salgarello, Rossella Gaudino, Laura Baggio, Andrea Bordugo
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in childhood (Horm Res 70:65-72, 2008; J Clin Endocr Metab 93:869-875, 2008). 18-Fluoro-L-dihydroxy-phenylalanine (18F-DOPA) positron emission tomography (PET) can detect areas of increased activity in the pancreas and may differentiate focal from diffuse CHI (J Clin Endocr Metab 93:869-875, 2008; Radiology 253:216-222, 2009). We here report the case of a girl who complained of recurrent episodes of severe hypoglycaemia despite previous partial pancreatectomy...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242276/oral-sodium-butyrate-impacts-brain-metabolism-and-hippocampal-neurogenesis-with-limited-effects-on-gut-anatomy-and-function-in-pigs
#5
David Val-Laillet, Sylvie Guérin, Nicolas Coquery, Isabelle Nogret, Michèle Formal, Véronique Romé, Laurence Le Normand, Paul Meurice, Gwénaëlle Randuineau, Paul Guilloteau, Charles-Henri Malbert, Patricia Parnet, Jean-Paul Lallès, Jean-Pierre Segain
Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neurocognitive alterations. Our aim was to assess whether oral butyrate could modulate brain metabolism and plasticity and if this would relate to gut function. Sixteen pigs were subjected to sodium butyrate (SB) supplementation via beverage water or water only [control (C)]. All pigs had blood sampled after 2 and 3 wk of treatment, and were subjected to a brain positron emission tomography after 3 wk. Animals were euthanized after 4 wk to sample pancreas, intestine, and brain for gut physiology and anatomy measurements, as well as hippocampal histology, Ki67, and doublecortin (DCX) immunohistochemistry...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29242089/cocos-nucifera-in-combination-with-metformin-for-modulation-of-diabetic-symptoms-in-streptozotocin-induced-diabetic-rats
#6
Ginpreet Kaur, Himanshu Sankrityayan, Deepashree Dixit, Priyanka Jadhav
BACKGROUND: Cocos nucifera, belonging to Arecaceae family, holds quite an importance in the Indian traditional medicinal system. C.nucifera inflorescence (CnI) has been reported in the literature to be useful in the treatment of diarrhoea, dysentery, diabetes, and dyspepsia. In this study, we aimed to evaluate the efficacy of CnI as an adjuvant with metformin in ameliorating Type-2 diabetes mellitus (T2-DM). OBJECTIVE: To evaluate antidiabetic activity of CnI in combination with metformin in Streptozotocin (STZ) induced diabetic rats...
December 12, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29241452/pancreatic-schwannoma-a-case-report-and-an-updated-40-year-review-of-the-literature-yielding-68-cases
#7
Yuntong Ma, Bingqi Shen, Yingmei Jia, Yanji Luo, Yisu Tian, Zhi Dong, Wei Chen, Zi-Ping Li, Shi-Ting Feng
BACKGROUND: Pancreatic schwannoma is a rare tumor. Preoperative diagnosis of pancreatic schwannoma is challenging due to its tendency to mimic other lesions of the pancreas. We describe a case of pancreatic schwannoma and present a review of the cases currently reported in the English literature to identify characteristics of pancreatic schwannoma on imaging. CASE PRESENTATION: A 53-year-old male presented with a history of intermittent periumbilical abdominal pain and lower back pain for 1 week...
December 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29241340/a-single-center-experience-with-tacrolimus-lcp-envarsus-xr-in-pancreas-transplant-recipients
#8
L Kerstenetzky, J L Descourouez, M R Jorgenson, D C Felix, D A Mandelbrot, R R Redfield, J S Odorico
No abstract text is available yet for this article.
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29240881/nrf2-promotes-mutant-k-ras-p53-driven-pancreatic-carcinogenesis
#9
Shin Hamada, Keiko Taguchi, Atsushi Masamune, Masayuki Yamamoto, Tooru Shimosegawa
The Keap1-Nrf2 system contributes to the maintenance of homeostasis by regulating oxidative stress responses in normal tissues and organs, and is exploited in various cancers for proliferation, survival and acquisition of therapy resistance. Pancreatic cancer remains one of the intractable cancers, despite the improved clinical outcomes of other types of cancer, due to its invasive and refractory nature to therapeutic intervention. The current study aimed to clarify the contribution of Nrf2 to pancreatic carcinogenesis using a pancreas-specific mutant K-ras and p53 (KPC) mouse model...
June 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29240036/solid-pseudopapillary-neoplasm-of-the-pancreas-in-children-and-adults-a-national-study-of-369-patients
#10
Harold J Leraas, Jina Kim, Zhifei Sun, Brian Ezekian, Brian C Gulack, Christopher R Reed, Elisabeth T Tracy
BACKGROUND: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor in children, with current evidence limited to single-center studies. We examined treatment and clinical outcomes for pediatric and adult SPN with a national data set. METHODS: The 2004 to 2013 National Cancer Data Base was queried to identify all patients diagnosed with SPN. The cohort was stratified by age (pediatric and adult) defined as below 18 years and 18 years and above, respectively...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29239345/extramucosal-pancreaticojejunostomy-at-laparoscopic-pancreaticoduodenectomy
#11
Servet Karagul, Cuneyt Kayaalp, Fatih Sumer, Mehmet Ali Yagci
While the 'best pancreatic anastomosis technique' debate is going during Whipple procedure, the laparoscopic pancreaticoduodenectomy lately began to appear more and more often in the medical literature. All the popular anastomosis techniques used in open pancreas surgery are being experienced in laparoscopic pancreaticoduodenectomy. However, when they were adapted to laparoscopy, their implementation was not technically easy, and assistance of robotic surgery was sometimes required at the pancreatic anastomosis stage of the procedure...
January 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29239037/well-differentiated-pancreatic-neuroendocrine-tumours-pannets-and-poorly-differentiated-pancreatic-neuroendocrine-carcinomas-pannecs-concepts-issues-and-a-practical-diagnostic-approach-to-high-grade-g3-cases
#12
REVIEW
Aatur D Singhi, David S Klimstra
With increasing accessibility and advancements in abdominal imaging modalities, the incidence of pancreatic neuroendocrine neoplasms has increased steadily during the past few decades. By definition, neuroendocrine neoplasms of the pancreas show neuroendocrine differentiation, but they represent a broad and heterogeneous group of neoplasms with diverse clinical and pathological characteristics. The majority of pancreatic neuroendocrine neoplasms can be classified as well-differentiated pancreatic neuroendocrine tumours (PanNETs) or poorly differentiated pancreatic neuroendocrine carcinomas (PanNECs)...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238893/postprandial-cardiogenic-syncope-caused-by-gastric-polyp-induced-pyloric-obstruction-in-an-elderly-woman-with-a-giant-hiatal-hernia-a-case-report
#13
Hideyuki Saito, Tatsuya Miyazaki, Makoto Sohda, Makoto Sakai, Hiroaki Honjyo, Yuuji Kumakura, Tomonori Yoshida, Takehiko Yokobori, Koji Kurosawa, Hiroyuki Kuwano
BACKGROUND: Hiatal hernias are common. In some reports, hiatal hernias have been implicated in causing dyspnea, syncope, and heart failure. CASE PRESENTATION: An 82-year-old woman with a hiatal hernia was admitted to our hospital because she had experienced postprandial syncope during the last few years. Esophagogastroduodenoscopy revealed a large hiatal hernia and a pedunculated polyp of the stomach antrum that fit into the pylorus. An upper gastrointestinal contrast study showed that the entire stomach had relocated to the thoracic cavity and that the body of the stomach was located above the fundus, resulting in a so-called upside-down stomach...
December 13, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29238876/independent-association-between-prediabetes-and-future-pancreatic-fat-accumulation-a-5-year-japanese-cohort-study
#14
Hajime Yamazaki, Shinichi Tauchi, Miho Kimachi, Mitsuru Dohke, Nagisa Hanawa, Yoshihisa Kodama, Akio Katanuma, Yosuke Yamamoto, Shunichi Fukuhara, Shingo Fukuma
BACKGROUND: The association between pancreatic fat and glucose dysmetabolism has been reported in several cross-sectional studies; however, a recent longitudinal study showed that baseline pancreatic fat did not cause subsequent diabetes mellitus. We hypothesized that pancreatic fat is not a cause but a manifestation of glucose dysmetabolism and aimed to investigate the association between baseline prediabetes and future pancreatic fat accumulation. METHODS: Between 2008 and 2015, 198 nondiabetic participants, who underwent a health check-up via unenhanced computed tomography (CT) twice with CT intervals ≥ 5 years, were enrolled as prediabetes (n = 48) and non-prediabetes participants (n = 150)...
December 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29237302/the-hypoglycemic-and-antioxidant-activities-of-garden-cress-lepidium-sativum-l-seed-on-alloxan-induced-diabetic-male-rats
#15
Eman S Attia, Afaf H Amer, Manal A Hasanein
The hypoglycemic and antioxidants activities of the methanol extract of Lepidium sativum seeds was tested in alloxan-induced diabetic male rats. Thirty male albino rats weighing 190-200 g were divided into five groups as follows: negative control, positive control and three diabetic groups treated with three concentrations of L. sativum methanol extract for four weeks. Induction of hyperglycemia in the positive control group increased blood glucose, glycated hemoglobin A1c, immunoglobulins, liver enzyme, lipid peroxide and kidney function, total cholesterol, low-density lipoproteins, very low-density lipoproteins and decreased antioxidants and high-density lipoproteins compared with the negative control...
December 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29237160/hydrogen-treatment-protects-mice-against-chronic-pancreatitis-by-restoring-regulatory-t-cells-loss
#16
Luguang Chen, Chao Ma, Yun Bian, Jing Li, Tiegong Wang, Li Su, Jianping Lu
BACKGROUND/AIMS: Chronic pancreatitis is an inflammatory disease of the pancreas characterized by progressive tissue destruction and fibrogenesis. The development of chronic pancreatitis is associated with immune cell dysregulation. Currently, the specific and effective treatment of chronic pancreatitis remains absent. METHODS: By using an L-arginine induced chronic pancreatitis mouse model, we tested the therapeutic potential of hydrogen, a strong hydroxyl radicals scavenger, in the chronic pancreatitis model...
December 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29236747/a-meta-analysis-of-effects-of-post-hatch-food-and-water-deprivation-on-development-performance-and-welfare-of-chickens
#17
Ingrid C de Jong, Johan van Riel, Marc B M Bracke, Henry van den Brand
A 'meta-analysis' was performed to determine effects of post-hatch food and water deprivation (PHFWD) on chicken development, performance and welfare (including health). Two types of meta-analysis were performed on peer-reviewed scientific publications: a quantitative 'meta-analysis' (MA) and a qualitative analysis (QA). Previously reported effects of PHFWD were quantified in the MA, for variables related to performance, mortality and relative yolk sac weight. The QA counted the number of studies reporting (non-)significant effects when five or more records were available in the data set (i...
2017: PloS One
https://www.readbyqxmd.com/read/29235528/identification-of-newly-committed-pancreatic-cells-in-the-adult-mouse-pancreas
#18
Mairobys Socorro, Angela Criscimanna, Patricia Riva, Manuj Tandon, Krishna Prasadan, Ping Guo, Abhinav Humar, Sohail Z Husain, Steven D Leach, George K Gittes, Farzad Esni
Multipotent epithelial cells with high Aldehyde dehydrogenase activity have been previously reported to exist in the adult pancreas. However, whether they represent true progenitor cells remains controversial. In this study, we isolated and characterized cells with ALDH activity in the adult mouse or human pancreas during physiological conditions or injury. We found that cells with ALDH activity are abundant in the mouse pancreas during early postnatal growth, pregnancy, and in mouse models of pancreatitis and type 1 diabetes (T1D)...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235373/pro-inflammatory-cytokine-induced-lipolysis-after-an-episode-of-acute-pancreatitis
#19
Sayali A Pendharkar, Ruma G Singh, Maxim S Petrov
CONTEXT: Pro-inflammatory cytokine-stimulated lipolysis is one of the mechanisms underlying the pathogenesis of type 2 diabetes. However, whether it plays a role in the pathogenesis of post-pancreatitis diabetes mellitus (PPDM) remains unknown. OBJECTIVE: To investigate the associations between markers of lipid metabolism and pro-inflammatory cytokines in individuals after acute pancreatitis (AP) in general, and in individuals with abnormal glucose metabolism (AGM) following AP in particular...
December 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29235221/liver-transplant-for-metastatic-pancreatoblastoma-7-year-event-free-survival-after-chemotherapy-pancreatectomy-complete-hepatectomy-and-liver-transplant
#20
A A Ghaffarian, L Book, R L Meyers
Pancreatoblastoma is a rare malignant tumor in children. Surgical resection of the tumor is necessary for cure; however, due to its aggressive nature, it is often unresectable at presentation due to tumor size, local invasion, and/or metastasis. Because it is a rare tumor, there is currently no standard treatment regimen. We report a case of a 4-year-old boy who presented with metastatic pancreatoblastoma with multiple large metastases involving all four sectors of the liver. We began treatment with chemotherapy (cisplatin, 5FU, vincristine, and doxorubicin), which significantly reduced the tumor burden in both the pancreas and liver...
December 13, 2017: Pediatric Transplantation
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