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Hypoactive sexual desire disorder

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https://www.readbyqxmd.com/read/28079402/sexual-dysfunction-in-premenopausal-women-could-be-related-to-hormonal-profile
#1
Fabiene Bernardes Castro Vale, Bruna Barbosa Coimbra, Gerson Pereira Lopes, Selmo Geber
Female sexual dysfunction (FSD) is a public health problem that affects women's quality of life. Although the relationship between some hormones and the FSD has been described, it is not well established for all hormones. Therefore, the aim of our study was to evaluate the association between hormonal dysfunction and sexual dysfunction in premenopausal women. We performed a cross-sectional study with 60 patients with regular menstrual cycles, with age ranging from 18 to 44 years, with previous diagnosis of FSD...
January 12, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28050188/psychometric-properties-of-the-sexual-interest-and-desire-inventory-female-for-diagnosis-of-hypoactive-sexual-desire-disorder-the-persian-version
#2
Mina Malary, Mehdi Pourasghar, Soghra Khani, Mahmood Moosazadeh, Zeinab Hamzehgardeshi
Objective: Hypoactive sexual desire Disorder (HSDD) is a common sexual problem among women. Sexual interest and desire inventory -female (SIDI-F) has been widely validated and used to measure sexual desire in women. The aim of this study was to determine the psychometric properties of the Persian version of SIDI-F for Iranian population. Method: This was a methodological study on the psychometric properties of SIDI -F. This report describes the process and principles used in the translation and cultural adaptation of the SIDI-F on 40 women of reproductive age who were selected using convenience sampling method...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28041924/what-sexual-behaviors-relate-to-decreased-sexual-desire-in-women-a-review-and-proposal-for-end-points-in-treatment-trials-for-hypoactive-sexual-desire-disorder
#3
REVIEW
Robert Pyke, Anita Clayton
INTRODUCTION: Counts of satisfying sexual events (SSEs) per month have been criticized as an end point in treatment trials of women with hypoactive sexual desire disorder (HSDD) but grounding improvement in sexual desire by assessing changes in sexual behavior remains of some importance. METHODS: We conducted a literature review to find validated measurements that are specific sexual behavioral correlates of low sexual desire. We compared expert-proposed criteria for dysfunctional desire, expert-developed sets of scale items, and self-rated scales developed before issuance of, or in accordance with, the Food and Drug Administration's guidance on developing patient-reported outcomes...
December 29, 2016: Sexual Medicine
https://www.readbyqxmd.com/read/27916394/hypoactive-sexual-desire-disorder-international-society-for-the-study-of-women-s-sexual-health-isswsh-expert-consensus-panel-review
#4
REVIEW
Irwin Goldstein, Noel N Kim, Anita H Clayton, Leonard R DeRogatis, Annamaria Giraldi, Sharon J Parish, James Pfaus, James A Simon, Sheryl A Kingsberg, Cindy Meston, Stephen M Stahl, Kim Wallen, Roisin Worsley
The objective of the International Society for the Study of Women's Sexual Health expert consensus panel was to develop a concise, clinically relevant, evidence-based review of the epidemiology, physiology, pathogenesis, diagnosis, and treatment of hypoactive sexual desire disorder (HSDD), a sexual dysfunction affecting approximately 10% of adult women. Etiologic factors include conditions or drugs that decrease brain dopamine, melanocortin, oxytocin, and norepinephrine levels and augment brain serotonin, endocannabinoid, prolactin, and opioid levels...
January 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27916205/efficacy-and-safety-of-transdermal-testosterone-in-postmenopausal-women-with-hypoactive-sexual-desire-disorder-a-systematic-review-and-meta-analysis
#5
Chiara Achilli, Jyotsna Pundir, Parimalam Ramanathan, Luca Sabatini, Haitham Hamoda, Nick Panay
OBJECTIVE: To systematically review and summarize the existing evidence related to the efficacy and safety of transdermal T in postmenopausal women for the treatment of hypoactive sexual desire disorder (HSDD). DESIGN: Systematic reviews and meta-analysis. SETTING: Not applicable. PATIENT(S): Seven randomized controlled trials enrolled 3,035 participants; 1,350 women were randomized to treatment with T patch, and 1,379 women were randomized to placebo...
December 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27875946/the-role-of-sexual-dysfunction-and-infertility-on-reproductive-health-in-diabetics-pathogenesis-evaluation-and-management
#6
Jason Gandhi, Gautam Dagur, Kelly Warren, Noel Smith, Sardar Ali Khan
BACKGROUND: Uncontrolled or long-term diabetes mellitus is conducive to vascular and oxidative stress disturbances that impede several physiological systems, which may in turn elicit psychological symptoms. OBJECTIVE: We assess the sexual and hormonal complications of diabetes mellitus that impair reproductive function in males and females. METHOD: A comprehensive MEDLINE® search was guided using key words relevant to diabetes mellitus and reproductive health...
November 22, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27872027/how-the-emotional-motor-system-controls-the-pelvic-organs
#7
REVIEW
Gert Holstege
INTRODUCTION: The brain has two goals: survival of the individual and survival of the species. It ensures that the body resides in safe circumstances and can obtain sufficient drink and food. It also has to produce and protect offspring. Its most important tool is its motor system, which consists of the voluntary and emotional motor systems. AIM: To explain how the brain uses its emotional motor system to control the pelvic organs. METHODS: Anatomic and physiologic data in cats and humans are used to find out how this motor system works and what parts of the brain and brainstem are involved...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27872021/hypoactive-sexual-desire-disorder-a-review-of-epidemiology-biopsychology-diagnosis-and-treatment
#8
REVIEW
Sharon J Parish, Steven R Hahn
INTRODUCTION: Hypoactive Sexual Desire Disorder (HSDD) is defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Revised (DSM-IV-TR) as persistent deficient sexual fantasies and desire for sexual activity that causes marked distress or interpersonal difficulty. In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), HSDD has been subsumed by Female Sexual Interest/Arousal Disorder. However, decades of research based on DSM-IV-TR HSDD criteria form the foundation of our understanding of the essential symptom of distressing low sexual desire, its epidemiology, clinical management, and treatment...
April 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27871953/prevalence-of-female-sexual-dysfunction-among-premenopausal-women-a-systematic-review-and-meta-analysis-of-observational-studies
#9
REVIEW
Megan E McCool, Andrea Zuelke, Melissa A Theurich, Helge Knuettel, Cristian Ricci, Christian Apfelbacher
INTRODUCTION: Epidemiologic research in female sexual dysfunction (FSD) has gained momentum in recent years, particularly in clinical populations and in menopausal women. However, sexual dysfunction also affects premenopausal women in general populations. Previous literature reviews have been unable to quantify the burden of FSD in general populations. This has been due in part to different definitions of dysfunction, heterogeneous study design, and the wide variety of measurement tools used...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27858170/flibanserin-and-its-discontents
#10
REVIEW
Awais Aftab, Cheryl Chen, Jacob McBride
In August 2015, flibanserin (brand name Addyi) was approved by the Food and Drug Administration (FDA) for treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. This article summarizes and promotes discussion regarding the numerous controversies that have enclosed flibanserin since the very beginning. This includes questions related to flibanserin's safety and efficacy and the validity of the clinical trials. Also included are philosophical considerations surrounding the diagnosis of hypoactive sexual desire disorder and pharmacological treatment of low libido...
November 17, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27843072/toward-a-more-evidence-based-nosology-and-nomenclature-for-female-sexual-dysfunctions-part-ii
#11
Sharon J Parish, Andrew T Goldstein, Sue W Goldstein, Irwin Goldstein, James Pfaus, Anita H Clayton, Annamaria Giraldi, James A Simon, Stanley E Althof, Gloria Bachmann, Barry Komisaruk, Roy Levin, Susan Kellogg Spadt, Sheryl A Kingsberg, Michael A Perelman, Marcel D Waldinger, Beverly Whipple
INTRODUCTION: Current Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) definitions of sexual dysfunction do not identify all sexual problems experienced clinically by women and are not necessarily applicable for biologic or biopsychosocial management of female sexual dysfunction. A unified nomenclature system enables clinicians, researchers, and regulatory agencies to use the same language and criteria for determining clinical end points, assessing research results, and managing patients...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27823751/female-sexual-dysfunction-fsd-prevalence-and-impact-on-quality-of-life-qol
#12
REVIEW
Prof Rossella E Nappi, Laura Cucinella, Silvia Martella, Margherita Rossi, Lara Tiranini, Ellis Martini
Female sexual dysfunction (FSD) and quality of life (QOL) are both multidimensional and have a bidirectional relationship across the reproductive life span and beyond. Methodological difficulties exist in estimating the real prevalence of FSD because it is hard to determine the level of distress associated with sexual symptoms in a large-scale survey. Approximately 40-50% of all women report at least one sexual symptom, and some conditions associated with hormonal changes at menopause, such as vulvovaginal atrophy (VVA) and hypoactive sexual desire disorder (HSDD), have a significant impact on sexual function and QOL...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27784209/systematic-review-and-meta-analysis-of-flibanserin-s-effects-and-adverse-events-in-women-with-hypoactive-sexual-desire-disorder
#13
Amirhossein Sahebkar, Seyed Hassan Saadat, Yunes Panahi, Ali Kabir, Khaled Rahmani, Milad Hosseinialhashemi
The efficacy and safety of flibanserin in the treatment of Hypoactive Sexual Desire Disorder (HSDD) is controversial. We reviewed existing evidence on the efficacy and safety of flibanserin in treating HSDD, and performed a meta-analysis of reported effects. Literature search was performed on PubMed, Scopus, and Cochrane library to find all trials on the efficacy of flibanserin in HSDD. Meta-analysis was performed using fixed- and random-effects models. Egger's test and "trim and fill" methods were used for the assessment of publication bias and imputation of potentially missing studies, respectively...
October 25, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27760089/efficacy-of-tribulus-terrestris-for-the-treatment-of-hypoactive-sexual-desire-disorder-in-postmenopausal-women-a-randomized-double-blinded-placebo-controlled-trial
#14
Karla Zanolla Dias de Souza, Fabiene Bernardes Castro Vale, Selmo Geber
OBJECTIVE: The objective of this study was to evaluate the efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women and evaluate its effect on the serum levels of testosterone. METHODS: We performed a prospective randomized, double-blinded, placebo-controlled study, during 18 months. A total of 45 healthy sexually active postmenopausal women reporting diminished libido were selected to participate in the study and were randomly assigned to receive 750 mg/d of T terrestris or placebo for 120 days...
November 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27738371/sexual-pain-among-malaysian-women-receiving-antidepressant-a-comparison-between-escitalopram-and-fluoxetine
#15
Hatta Sidi, Duni Asmidar, Loh Huai Seng, Nik Ruzyanei Nik Jaafar, Marhani Midi, Ng Chong Guan
OBJECTIVES: The current study compares the risk of sexual pain in depressed female patients in remission between those who were treated with Escitalopram and Fluoxetine. The associated factors were also examined. METHODS: This is a cross-sectional study involved 112 depressed female patients (56 treated with Escitalopram and 56 treated with Fluoxetine) who were in remission (as defined by Diagnostic and Statistical Manual-IV (DSM-IV) in the past 2 months and Montgomery-Asberg Depression Rating Scale (MADRS) score of ≤ 10) from the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC)...
March 1, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/27663307/-efficacy-and-safety-of-flibanserin-new-female-viagra-%C3%A2-literature-review
#16
C Terrier, J-E Terrier
INTRODUCTION: In August 2015, the US Food and Drug Administration (FDA) has approved Addyi(®) (flibanserin) for treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in pre-menopausal women. We carried out a systematic review and meta-analysis to assess the efficacy and safety of the drug in women with HSDD. PATIENTS AND METHODS: A systematic literature review from the PubMed database search was carried out until April 2016 using the following keywords: "HSDD", "flibanserin", "sexual desire" and "ransomised controlled trial"...
September 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27592287/sexuality-and-quality-of-life-in-women-with-a-prior-diagnosis-of-breast-cancer-after-risk-reducing-salpingo-oophorectomy
#17
Paige E Tucker, Christobel Saunders, Max K Bulsara, Jason Jit-Sun Tan, Stuart G Salfinger, Helena Green, Paul A Cohen
OBJECTIVES: To investigate the prevalence of sexual dysfunction in women with a history of breast cancer following risk-reducing salpingo-oophorectomy (RRSO). A secondary objective was to examine the effect of a prior diagnosis of breast cancer, and other factors, on sexuality and quality of life (QoL) outcomes. STUDY DESIGN: Cross-sectional study of 119 women who underwent RRSO between 2009 and 2014. MAIN OUTCOME MEASURES: Data were collected via a questionnaire comprising demographic information and validated measures of sexual function, sexual distress, relationship satisfaction, body image, psychological stress, menopause symptoms and general quality of life...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27583427/flibanserin-ineffective-for-hypoactive-sexual-desire-disorder-in-women
#18
Allen F Shaughnessy
No abstract text is available yet for this article.
September 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27517339/what-s-new-in-the-world-of-postmenopausal-sex
#19
Cheryl B Iglesia
PURPOSE OF REVIEW: The purpose of this review is to describe new terminology for vulvovaginal atrophy and female sexual dysfunction and to highlight recent findings related to vaginal moisturizers, lubricants and prescription estrogen preparations. RECENT FINDINGS: Sexual health is a marker for overall health. A minority (40%) of healthcare providers routinely ask about sexual problems and its impact on quality of life. New terminology by the American Psychiatric Association divides female sexual disorders into three categories: arousal/interest disorder, orgasmic disorder and genital pain and penetration disorder...
October 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27287358/flibanserin-and-female-sexual-desire
#20
Heidi Collins Fantasia
Female hypoactive sexual desire disorder (HSDD) is one type of sexual problem that can affect women. It is characterized by low or absent sexual desire that cannot be attributed to another cause and results in difficulty in interpersonal relationships. HSDD is not well understood, and women may not report symptoms of difficulties to their health care providers. In August 2015, the U.S. Food and Drug Administration approved flibanserin, a nonhormonal oral medication for the treatment of HSDD in premenopausal women...
June 2016: Nursing for Women's Health
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