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Female libido disorder

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https://www.readbyqxmd.com/read/28291031/a-sex-specific-dose-response-curve-for-testosterone-could-excessive-testosterone-limit-sexual-interaction-in-women
#1
Jill M Krapf, James A Simon
Testosterone treatment increases sexual desire and well-being in women with hypoactive sexual desire disorder; however, many studies have shown only modest benefits limited to moderate doses. Unlike men, available data indicate women show a bell-shaped dose-response curve for testosterone, wherein a threshold dosage of testosterone leads to desirable sexual function effects, but exceeding this threshold results in a lack of further positive sexual effects or may have a negative impact. Emotional and physical side-effects of excess testosterone, including aggression and virilization, may counteract the modest benefits on sexual interaction, providing a possible explanation for a threshold dose of testosterone in women...
April 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28025939/serotonin-selective-reuptake-inhibitors-ssris-and-female-sexual-dysfunction-fsd-hypothesis-on-its-association-and-options-of-treatment
#2
Nurul Azmi Mahamad Rappek, Hatta Sidi, Jaya Kumar, Sazlina Kamarazaman, Srijit Das, Ruziana Masiran, Najwa Baharudin, Muhammad Hatta
Sexual dysfunctions are commonly seen in women on selective serotonin reuptake inhibitors (SSRIs). The complexities of female sexual functioning are reflected through modulation of inter-playing factors like the neuropsychophysiological factors, inter-personal and relationship issue, psychiatric co-morbidities and physical disorder. The incidence of SSRIs-induced FSD is difficult to estimate because of the potentially confounding effects of SSRIs, presence of polypharmacy, marital effect, socio-cultural factors and due to the design and assessment problems in majority of the studies...
December 27, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27788052/efficacy-and-safety-of-an-injectable-combination-hormonal-contraceptive-for-men
#3
Hermann M Behre, Michael Zitzmann, Richard A Anderson, David J Handelsman, Silvia W Lestari, Robert I McLachlan, M Cristina Meriggiola, Man Mohan Misro, Gabriela Noe, Frederick C W Wu, Mario Philip R Festin, Ndema A Habib, Kirsten M Vogelsong, Marianne M Callahan, Kim A Linton, Doug S Colvard
CONTEXT: The development of a safe and effective reversible method of male contraception is still an unmet need. OBJECTIVE: Evaluation of suppression of spermatogenesis and contraceptive protection by coadministered im injections of progestogen and testosterone. DESIGN: Prospective multicentre study. SETTING: Ten study centers. PARTICIPANTS: Healthy men, aged 18-45 years, and their 18- to 38-year-old female partners, both without known fertility problems...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27760089/efficacy-of-tribulus-terrestris-for-the-treatment-of-hypoactive-sexual-desire-disorder-in-postmenopausal-women-a-randomized-double-blinded-placebo-controlled-trial
#4
Karla Zanolla Dias de Souza, Fabiene Bernardes Castro Vale, Selmo Geber
OBJECTIVE: The objective of this study was to evaluate the efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women and evaluate its effect on the serum levels of testosterone. METHODS: We performed a prospective randomized, double-blinded, placebo-controlled study, during 18 months. A total of 45 healthy sexually active postmenopausal women reporting diminished libido were selected to participate in the study and were randomly assigned to receive 750 mg/d of T terrestris or placebo for 120 days...
November 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27544297/diabetes-and-sexuality
#5
REVIEW
Fuat Kizilay, Helena Elizabeth Gali, Ege Can Serefoglu
INTRODUCTION: Deterioration in sexual functioning is one of the major and serious complications of diabetes. This common metabolic disorder not only affects sexuality through microvascular and nerve damage but also has psychological aspects. In men, the primary complications are erectile dysfunction, ejaculatory dysfunction, and loss of libido. Women similarly experience sexual problems, including decreased libido and painful intercourse. AIM: To summarize the effects of diabetes on sexuality, evaluate the impact of diabetes on sexual function, and assess the conventional and novel treatment approaches based on recent studies...
January 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/26610872/psychological-treatment-trials-for-hypoactive-sexual-desire-disorder-a-sexual-medicine-critique-and-perspective
#6
REVIEW
Robert E Pyke, Anita H Clayton
INTRODUCTION: Publications claim efficacy for treatment of hypoactive sexual desire disorder (HSDD) in women with cognitive behavior therapy (CBT) and mindfulness meditation training (MMT). However, no review has evaluated the evidence for these therapies from the rigorous perspective of sexual medicine. AIMS: The aim of this study was to evaluate the published controlled trials of CBT and MMT for disorders of sexual desire from the perspective of sexual medicine standards of control paradigms, risk/benefit ratios, and clinical significance...
December 2015: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/26591724/sexual-dysfunction-during-primiparous-and-multiparous-women-following-vaginal-delivery
#7
Mehri Makkii, Nooshin Abdoli Yazdi
Normal sexual functioning comprises of sexual activity together with transition through the phases from arousal to relaxation with no problem. Delivery has different effects on body organs, especially, on genitalia the disorder of which can cause sexual dysfunctions. In this study, an attempt is made to compare postpartum sexual dysfunction among primiparous and multiparous women. This descriptive cross sectional study was done on 564 primiparous (331) and multiparous (233) women chosen from among those who were present at health and clinical centres in Yazd, Iran...
October 2012: Tanzania Journal of Health Research
https://www.readbyqxmd.com/read/26591078/-an-exploration-of-sexual-desire-and-sexual-activities-of-women-with-psychosis
#8
P Huguelet, S Mohr, M Boucherie, M Yaron, N Perroud, F Bianchi-Demicheli
Most clinicians avoid discussing sexuality with patients with severe mental disorders. Sexual disturbances can be related to medication, to psychological issues such as self-stigma and anhedonia, and to the social context. We studied desire and sexual practices in women suffering from schizophrenia, in comparison with healthy women. Contrary to previous research, women with schizophrenia featured dyadic and individual desire similar to women of comparable age. Yet, only half of women with psychosis had sexual practice, either alone or with a partner...
September 16, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26539012/gender-differences-in-depressive-symptom-profile-results-from-nationwide-general-population-surveys-in-korea
#9
Ji-Hyun Kim, Maeng Je Cho, Jin Pyo Hong, Jae Nam Bae, Seong-Jin Cho, Bong-Jin Hahm, Dong-Woo Lee, Jong-Ik Park, Jun-Young Lee, Hong Jin Jeon, Sung Man Chang
This study investigated gender differences in symptom profiles of major depressive disorder (MDD) in the Korean general population. Data were pooled from the series of nationwide Korean Epidemiologic Catchment Area surveys conducted in 2001, 2006 and 2011, respectively. Of the 18,807 participants, 507 (397 women and 110 men) were diagnosed with MDD within the prior 12 months. In agreement with previous studies, women with MDD appeared to be more vulnerable to experiencing atypical depressive episodes defined as depression with two or more symptoms of fatigue, increased appetite and hypersomnia (P < 0...
November 2015: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/26395164/flibanserin-for-the-treatment-of-hypoactive-sexual-desire-disorder-in-premenopausal-women
#10
REVIEW
Ida Dhanuka, James A Simon
INTRODUCTION: Hypoactive sexual desire disorder (HSDD) is the most common form of female sexual dysfunction (FSD). Some theories suggest that HSDD has a neurobiological component linked to neurotransmitter imbalances. Flibanserin is the only FDA-approved treatment of HSDD; before its approval, the disorder was often left untreated or interventions were made using evidence-based psychological methods or 'off-label' use of bupropion, testosterone and other dopaminergic agents. AREAS COVERED: Flibanserin, a multifunctional serotonin agonist/antagonist, is approved as a nonhormonal option designed specifically for the treatment of HSDD...
2015: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/26382168/sexual-side-effects-of-antidepressant-and-antipsychotic-drugs
#11
REVIEW
Angel L Montejo, Laura Montejo, Felipe Navarro-Cremades
PURPOSE OF REVIEW: Psychotropic-related sexual dysfunction is a quite frequent issue in clinical practice, mainly in chronic treatments affecting both quality of life and compliance. RECENT FINDINGS: In the last decade fortunately antidepressants and antipsychotic compounds have been deeply screened in order to identify sexual adverse events that were commonly underdiagnosed and previously underestimated by clinicians and perhaps by pharmaceutical companies as well...
November 2015: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/26382159/sex-drive-and-sexual-desire
#12
REVIEW
Victoria Holloway, Kevan Wylie
PURPOSE OF REVIEW: Loss of sexual desire is increasingly recognized as a consequence of many disease processes, and one that can have a significant negative impact on quality of life. This review explores the biological and psychological aspects of desire, as well as the aetiology and therapeutic options for loss of desire. RECENT FINDINGS: Discoveries have been made in terms of the physiology of desire in men, in that it is affected by estradiol as well as testosterone...
November 2015: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/26124287/hypoactive-sexual-desire-disorder-inventing-a-disease-to-sell-low-libido
#13
Antonie Meixel, Elena Yanchar, Adriane Fugh-Berman
Condition branding is a marketing technique in which companies develop conditions concurrently with developing drugs; examples include gastro-oesophageal reflux disease, premenstrual dysphoric disorder, social anxiety disorder, erectile dysfunction and hypoactive sexual desire disorder. Although it is illegal for pharmaceutical companies to market drugs prior to regulatory approval, there are no restrictions on marketing diseases, and industry seeks to establish a disease state in the minds of clinicians years before an expected drug launch...
October 2015: Journal of Medical Ethics
https://www.readbyqxmd.com/read/26105109/dhea-metabolism-to-the-neurosteroid-androsterone-a-possible-mechanism-of-dhea-s-antidepressant-action
#14
RANDOMIZED CONTROLLED TRIAL
Rivka Ben Dor, Christine E Marx, Lawrence J Shampine, David R Rubinow, Peter J Schmidt
BACKGROUND: Alterations in neurosteroid secretion have been implicated in the efficacy of antidepressants. In a previous study, the adrenal androgen DHEA, a precursor of the neurosteroid androsterone, produced antidepressant and libido-enhancing effects in patients with midlife depression. To investigate the mechanisms underlying DHEA's behavioral effects in this same patient group, we examined plasma levels of four additional neurosteroids implicated in the regulation of affective behavior...
September 2015: Psychopharmacology
https://www.readbyqxmd.com/read/26003261/psychiatric-disorders-and-sexual-dysfunction
#15
REVIEW
Marcel D Waldinger
Sexual problems are highly prevalent among patients with psychiatric disorders. They may be caused by the psychopathology of the psychiatric disorder but also by its pharmacotherapy. Both positive symptoms (e.g., psychosis, hallucinations) as well as negative symptoms (e.g., anhedonia) of schizophrenia may negatively interfere with interpersonal and sexual relationships. Atypical antipsychotics have fewer sexual side-effects than the classic antipsychotics. Mood disorders may affect libido, sexual arousal, orgasm, and erectile function...
2015: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/25933671/between-dsm-and-icd-paraphilias-and-the-transformation-of-sexual-norms
#16
Alain Giami
The simultaneous revision of the two major international classifications of disease, the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases, serves as an opportunity to observe the dynamic processes through which social norms of sexuality are constructed and are subject to change in relation to social, political, and historical context. This article argues that the classifications of sexual disorders, which define pathological aspects of "sexually arousing fantasies, sexual urges or behaviors" are representations of contemporary sexual norms, gender identifications, and gender relations...
July 2015: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/25927027/comparison-of-sexual-dysfunction-in-women-using-depo-medroxyprogesterone-acetate-dmpa-and-cyclofem
#17
Giti Ozgoli, Zohre Sheikhan, Mahrokh Dolatian, Masoumeh Simbar, Maryam Bakhtyari, Malihe Nasiri
BACKGROUND: Sexual affairs are one of the physiological needs affecting human health. Sexual functioning disorders can reduce individual's capabilities and creativities. Sexual relations are in the center of women's quality of life. The most important family planning is to prevent unintended pregnancies. Injectable contraceptives protect women exposed to many complications and mortality due to unintended pregnancies, with tolerable effects on other aspects of women's life. An important aspect of women's life is sexual health...
April 2015: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/25918921/interventions-for-hirsutism-excluding-laser-and-photoepilation-therapy-alone
#18
REVIEW
Esther J van Zuuren, Zbys Fedorowicz, Ben Carter, Nikolaos Pandis
BACKGROUND: Hirsutism occurs in 5% to 10% of women of reproductive age when there is excessive terminal hair growth in androgen-sensitive areas (male pattern). It is a distressing disorder with a major impact on quality of life. The most common cause is polycystic ovary syndrome. There are many treatment options, but it is not clear which are most effective. OBJECTIVES: To assess the effects of interventions (except laser and light-based therapies alone) for hirsutism...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25847589/ptsd-and-sexual-dysfunction-in-men-and-women
#19
REVIEW
Rachel Yehuda, Amy Lehrner, Talli Y Rosenbaum
INTRODUCTION: Difficulties in sexual desire and function often occur in persons with posttraumatic stress disorder (PTSD), but many questions remain regarding the mechanisms underlying the occurrence of sexual problems in PTSD. AIM: The aim of this review was to present a model of sexual dysfunction in PTSD underpinned by an inability to regulate and redirect the physiological arousal needed for healthy sexual function away from aversive hyperarousal and intrusive memories...
May 2015: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/25802347/assessing-sexual-symptoms-and-side-effects-in-adolescents
#20
Amir Levine, Eleanor McGlinchey
No abstract text is available yet for this article.
April 2015: Pediatrics
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