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Gingival fibrosis

F Y Lyu, H F Wang, C J Xu, Z Xu, D M Li, Y T Chi
Objective: To investigate the concentrations and clinical significance of secreted frizzled-related protein-1(SFRP1) insaliva and gingival crevicular fluid of patients with oral submucous fibrosis (OSF) as well as the expression of SFRP1 in patients' OSF buccal mucosa. Methods: Twenty OSF patients aged 20 to 40 years old were recruited and randomly divided into two experimental groups, of which were triamcinolone acetonide group and combined triamcinolone acetonide and salvia miltiorrhiza group, respectively...
October 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Katarzyna Gawron, Katarzyna Łazarz-Bartyzel, Andrzej Fertala, Paweł Plakwicz, Jan Potempa, Maria Chomyszyn-Gajewska
BACKGROUND Hereditary gingival fibromatosis is characterized by slowly progressive enlargement of the gingiva that can present as an isolated condition or present as part of various syndromes. CASE REPORT An 11-year-old female reported with a gingival lesion that caused masticatory problems and poor oral hygiene. Periodontal examination revealed a dense tissue covering 30% of her teeth crowns within both jaws. Panoramic x-ray showed a normal bone height and teeth positioning. The patient did not use any medications, but a similar condition was also present in other family members...
September 9, 2016: American Journal of Case Reports
Béla Hunyady, Margit Abonyi, Klára Csefkó, Judit Gervain, Attila Haragh, Gábor Horváth, Viktor Jancsik, Erzsébet Makkai, Zsófia Müller, Pál Ribiczey, Béla Sipos, Olga Szabó, Ferenc Szalay, László Szentgyörgyi, István Tornai, Eszter Újhelyi, Márta Varga, György Weisz, Mihály Makara
INTRODUCTION: During 2011 and 2013, 155 Hungarian hepatitis C genotype 1 infected patients, mostly with advanced liver fibrosis, who did not respond to prior peginterferon + ribavirin dual therapy, started boceprevir based triple therapy in an early access program. AIM AND METHOD: Efficacy and safety of the therapy was retrospectively assessed based on sustained virologic responses, as well as on frequency and type of serious adverse events and of those leading to therapy discontinuation...
August 2016: Orvosi Hetilap
Sema Becerik, Peter Celec, Ali Gürkan, Veli Özgen Öztürk, Natalia Kamodyova, Gül Atilla, Gülnur Emingil
BACKGROUND: TGM-2 was shown to contribute to fibrosis by extracellular matrix accumulation in some organs and also activated by intracellular reactive oxygen species. The aim of this study was to investigate the levels of gingival crevicular fluid (GCF) and plasma TGM-2 and oxidative stress markers in cyclosporinA (CsA)-induced gingival overgrowth (GO). MATERIALS AND METHODS: Twenty healthy (H) individuals, 20 gingivitis (G), and CsA-medicated patients; 20 with GO (CsA GO+) and 20 without GO (CsA GO-) were enrolled...
July 29, 2016: Journal of Periodontology
Fares Kablan
INTRODUCTION: Peri-implantitis is a common condition, but no particular treatment protocol has shown to be definitively effective. Fat tissue in the oral cavity is widely available and easily accessed. The aim of the current study is to present a novel technique in the treatment of peri-implant lesions, utilizing a free fat tissue graft from the buccal fat pad (BFP). PATIENTS AND METHODS: Free fat graft (FFG) was harvested from the BFP in eight patients and used with bone substitutes to regenerate 22 peri-implant lesions...
July 2015: Annals of Maxillofacial Surgery
Mei-Chi Chang, Chiu-Po Chan, Yi-Jane Chen, Hsiang-Chi Hsien, Ya-Ching Chang, Sin-Yuet Yeung, Po-Yuan Jeng, Ru-Hsiu Cheng, Liang-Jiunn Hahn, Jiiang-Huei Jeng
Betel quid (BQ) chewing is an etiologic factor of oral submucous fibrosis (OSF) and oral cancer. There are 600 million BQ chewers worldwide. The mechanisms for the toxic and inflammatory responses of BQ are unclear. In this study, both areca nut (AN) extract (ANE) and arecoline stimulated epidermal growth factor (EGF) and interleukin-1α (IL-1α) production of gingival keratinocytes (GKs), whereas only ANE can stimulate a disintegrin and metalloproteinase 17 (ADAM17), prostaglandin E2 (PGE2) and 8-isoprostane production...
March 29, 2016: Oncotarget
W H Yang, Y T Deng, Y P Hsieh, K J Wu, M Y P Kuo
Transforming growth factor β (TGFβ) regulates cell proliferation, differentiation, migration, apoptosis, and extracellular matrix production. It also plays a pivotal role in the pathogenesis of gingival overgrowth. Thrombin is a key player in tissue repair, remodeling, and fibrosis after an injury, and it exerts profibrotic effects by activating protease-activated receptors. Connective tissue growth factor (CTGF or CCN2) modulates cell adhesion, migration, proliferation, matrix production, and wound healing...
July 2016: Journal of Dental Research
Maral Rahvar, Joyce Teng, Jinah Kim
Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disorder characterized by hyalinizing fibrosis of the skin and internal organs. Clinical features include multiple papular skin lesions, gingival hyperplasia, joint contractures, and osteolytic bone lesions. The systemic variant of JHF, known as infantile systemic hyalinosis (ISH), has an early onset and poor prognosis. Histological examination of cutaneous lesions shows bland-appearing fibroblasts within amorphous eosinophilic hyaline depositions...
May 2016: American Journal of Dermatopathology
Stacey Reiss, Daniel Sultan
Bisphosphonates (BPs) are routinely prescribed to prevent pathologic fractures in osteoporotic patients. Bisphosphonate-associated osteonecrosis of the jaw (BRONJ) is a rare, but serious complication, most often following extraction in patients treated with intravenous BPs. We report a case of BRONJ in a patient following six years of oral BP administration for the management of osteoporosis, complicated by four years of prednisone therapy for pulmonary fibrosis. This rare presentation led us to investigate other causative factors, in particular, glucocorticoids...
November 2015: New York State Dental Journal
J Chen, F Yang, X Yu, Y Yu, Y Gong
OBJECTIVES: Transforming growth factor (TGF)-β/Smad3 signaling promotes tissue fibrosis, and miR-29b is a downstream inhibitor of TGF-β/Smad3-mediated fibrosis, both of which may be involved in the pathogenesis of cyclosporine A-induced gingival overgrowth. The aim of this study is to investigate the effect of miR-29b and TGF-β/Smad3 signaling in cyclosporine A-stimulated rat gingival fibroblasts. MATERIAL AND METHODS: We explored the effect of cyclosporine A on cell proliferation, type Ι collagen (COL1) and alpha-smooth muscle actin (α-SMA) expressions in rat gingival fibroblasts with the Cell Counting Kit-8 assay, real-time polymerase chain reaction, western blot and immunofluorescence...
January 6, 2016: Journal of Periodontal Research
Benjamin A Baptist
Systemic Scleroderma (SSc) is an autoimmune disease that affects connective tissue, resulting in hardening skin, reduced vascular perfusion, gingival fibrosis, enlarged periodontal ligament, xerostomia, and trigeminal neuralgia. Secondary effects, including reduced oral opening and reduced manual dexterity may exacerbate the primary effects. Severe bone loss and premature tooth loss are common eventualities of SSc. Removable prosthetics can be a tedious option for these patients as the progression of the disease often leads to the impossibility of obtaining minimal standards of care, including stability, retention, and hygienic maintainability...
February 2016: Implant Dentistry
Rina Elimelech, Yaniv Mayer, Yolanda Braun-Moscovici, Eli E Machtei, Alexandra Balbir-Gurman
BACKGROUND: Systemic sclerosis (SSc) is a chronic disease with prominent vasculopathy, inflammation, production of autoantibodies, and tissue fibrosis. Periodontitis is a chronic inflammatory oral condition manifesting as microbial infection, inflammation and destruction of the alveolar bone. In both conditions tumor necrosis factor-alpha (TNFα) and other proinflammatory cytokines play an important role in pathogenesis. OBJECTIVES: To assess the periodontal status in SSc patients and compare these parameters to TNFα level in gingival crevicular fluid (GCF) of SSc patients and healthy controls...
September 2015: Israel Medical Association Journal: IMAJ
Astrid Truschnegg, Stephan Acham, Birgit Alexandra Kiefer, Norbert Jakse, Alfred Beham
OBJECTIVES: Aim of the present study was clinical and histopathological evaluation of a series of epulides to provide clinicians data to frequency distribution and biological behaviour of different underlying entities. MATERIALS AND METHODS: Ninety-two cases of epulides removed by CO2-laser at the Department of Oral Surgery and Radiology, Medical University of Graz from 2000 to 2014 were studied retrospectively for clinical data and histopathological diagnosis. RESULTS: In the presented study, histopathological examination revealed peripheral ossifying fibroma (32...
September 2016: Clinical Oral Investigations
Bharghavi Narayanan, Malathi Narasimhan
INTRODUCTION: Langerhans cells (LCs), are dendritic cells of the epithelium which play a role in an array of oral lesions from gingivitis to oral cancer. Oral Submucous Fibrosis (OSMF), a potentially malignant disorder (PMD), is an insidious chronic disease with juxta-epithelial inflammatory changes leading to fibrosis. Langerhans cells (LCs) may play a part in the ongoing inflammatory dysregulation of OSMF. OBJECTIVE: The study was aimed at elucidating the distribution of LCs in varying grades of OSMF...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
Shawna S Kim, Sarah Michelsons, Kendal Creber, Michael J Rieder, Douglas W Hamilton
Drug-induced gingival enlargement (DIGE) is a fibrotic condition that can be caused by the antihypertensive drug nifedipine and the anti-seizure drug phenytoin, but the molecular etiology of this type of fibrosis is not well understood and the role of confounding factors such as inflammation remains to be fully investigated. The aim of this study was to develop an ex vivo gingival explant system to allow investigation of the effects of nifedipine and phenytoin alone on human gingival tissue. Comparisons were made to the histology of human DIGE tissue retrieved from individuals with DIGE...
December 2015: Journal of Cell Communication and Signaling
Imran Khan, Ila Pant, Sivakrishna Narra, Rekha Radhesh, Kannan Ranganathan, Somanahalli Girish Rao, Paturu Kondaiah
Exposure of oral cavity to areca nut is associated with several pathological conditions including oral submucous fibrosis (OSF). Histopathologically OSF is characterized by epithelial atrophy, chronic inflammation, juxtaepithelial hyalinization, leading to fibrosis of submucosal tissue and affects 0.5% of the population in the Indian subcontinent. As the molecular mechanisms leading to atrophied epithelium and fibrosis are poorly understood, we studied areca nut actions on human keratinocyte and gingival fibroblast cells...
October 2015: Journal of Cellular and Molecular Medicine
Ila Pant, Neeraj Kumar, Imran Khan, Somanahalli Girish Rao, Paturu Kondaiah
Areca nut consumption has been implicated in the progression of Oral Submucous fibrosis (OSF); an inflammatory precancerous fibrotic condition. Our previous studies have demonstrated the activation of TGF-β signaling in epithelial cells by areca nut components and also propose a role for epithelial expressed TGF-β in the pathogenesis of OSF. Although the importance of epithelial cells in the manifestation of OSF has been proposed, the actual effectors are fibroblast cells. However, the role of areca nut and TGF-β in the context of fibroblast response has not been elucidated...
2015: PloS One
Rasika P Illeperuma, Do Kyeong Kim, Young Jin Park, Hwa Kyung Son, Jue Young Kim, Jinmi Kim, Doo Young Lee, Ki-Yeol Kim, Da-Woon Jung, Wanninayake M Tilakaratne, Jin Kim
Molecular crosstalk between cancer cells and fibroblasts has been an emerging hot issue in understanding carcinogenesis. As oral submucous fibrosis (OSF) is an inflammatory fibrotic disease that can potentially transform into squamous cell carcinoma, OSF has been considered to be an appropriate model for studying the role of fibroblasts during early stage carcinogenesis. In this sense, this study aims at investigating whether areca nut (AN)-exposed fibroblasts cause DNA damage of epithelial cells. For this study, immortalized hNOF (hTERT-hNOF) was used...
December 1, 2015: International Journal of Cancer. Journal International du Cancer
Thiago Alvares da Costa, Marcelo José Barbosa Silva, Polyanna Miranda Alves, Javier Emílio Lazo Chica, Emilio Zorzo Barcelos, Max Antonio Alves Giani, Gustavo Pompermaier Garlet, João Santana da Silva, Virmondes Rodrigues Júnior, Denise Bertulucci Rocha Rodrigues, Cristina Ribeiro de Barros Cardoso
Chronic periodontitis is a multifactorial inflammatory disease that affects supporting structures of the teeth. Although the gingival response is largely described, little is known about the immune changes in the alveolar bone and neighboring tissues that could indicate periodontal disease (PD) activity. Then, in this study we identified the ongoing inflammatory changes and novel biomarkers for periodontitis in the tissues directly affected by the destructive disease in PD patients. Samples were collected by osteotomy in 17 control subjects during extraction of third molars and 18 patients with advanced PD, in which alveoloplasty was necessary after extraction of teeth with previous extensive periodontal damage...
2015: Mediators of Inflammation
Hanan H Afifi, Ryoko Fukai, Noriko Miyake, Amina A Gamal El Din, Maha M Eid, Ola M Eid, Manal M Thomas, Tarek H El-Badry, Angie M S Tosson, Ghada M H Abdel-Salam, Naomichi Matsumoto
Generalized hypertrichosis is a feature of several genetic disorders, and the nosology of these entities is still provisional. Recent studies have implicated chromosome 17q24.2-q24.3 microdeletion and the reciprocal microduplication in a very rare form of congenital generalized hypertrichosis terminalis (CGHT) with or without gingival hyperplasia. Here, we report on a 5-year-old Egyptian girl born to consanguineous parents. The girl presented with CGHT and gingival hyperplasia for whom we performed detailed clinical, pathological, and molecular studies...
October 2015: American Journal of Medical Genetics. Part A
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