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Magnesium supplementation

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https://www.readbyqxmd.com/read/29137465/a-trial-on-the-effects-of-magnesium-zinc-calcium-vitamin-d-co-supplementation-on-glycemic-control-and-markers-of-cardio-metabolic-risk-in-women-with-polycystic-ovary-syndrome
#1
Mehri Jamilian, Maryam Maktabi, Zatollah Asemi
BACKGROUND: There is scarce data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk among women with polycystic ovary syndrome (PCOS). The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. METHODS: Sixty PCOS women were randomized into two groups and treated with 100 mg of magnesium, 4 mg of zinc, 400 mg of calcium plus 200 IU of vitamin D supplements (n = 30) or placebo (n = 30) twice a day for 12 weeks...
October 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29127547/the-effects-of-magnesium-and-zinc-co-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-and-gene-expression-related-to-inflammation-in-polycystic-ovary-syndrome-a-randomized-controlled-clinical-trial
#2
Faraneh Afshar Ebrahimi, Fatemeh Foroozanfard, Esmat Aghadavod, Fereshteh Bahmani, Zatollah Asemi
Magnesium and zinc are known to exert multiple beneficial effects including anti-inflammatory and antioxidant actions. To our knowledge, data on the effects of magnesium and zinc co-supplementation on biomarkers of inflammation and oxidative stress and gene expression related to inflammation in subjects of polycystic ovary syndrome (PCOS) are scarce. This study was conducted to evaluate the effects of magnesium and zinc co-supplementation on biomarkers of inflammation and oxidative stress and gene expression related to inflammation in subjects with PCOS...
November 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29118161/dietary-nutrient-intake-ethnicity-and-epigenetic-silencing-of-lung-cancer-genes-detected-in-sputum-in-new-mexican-smokers
#3
Shuguang Leng, Maria A Picchi, Huining Kang, Guodong Wu, Piotr T Filipczak, Daniel E Juri, Xiequn Zhang, W James Gauderman, Frank D Gilliland, Steven A Belinsky
Lung cancer (LC) gene methylation detected in sputum assesses field cancerization and predicts LC incidence. Hispanic smokers have higher LC susceptibility compared to non-Hispanic Whites (NHW). We aimed to identify novel dietary nutrients affecting LC gene methylation and determine the degree of ethnic disparity in methylation explained by diet. Dietary intakes of 139 nutrients were assessed using a validated Harvard food frequency questionnaire in 327 Hispanics and 1502 NHWs from the Lovelace Smokers cohort (LSC)...
November 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29113038/micronutrient-dietary-intake-in-latina-pregnant-adolescents-and-its-association-with-level-of-depression-stress-and-social-support
#4
Angelie Singh, Caroline Trumpff, Jeanine Genkinger, Alida Davis, Marisa Spann, Elizabeth Werner, Catherine Monk
Adolescent pregnant women are at greater risk for nutritional deficits, stress, and depression than their adult counterparts, and these risk factors for adverse pregnancy outcomes are likely interrelated. This study evaluated the prevalence of nutritional deficits in pregnant teenagers and assessed the associations among micronutrient dietary intake, stress, and depression. One hundred and eight pregnant Latina adolescents completed an Automated Self-Administered 24-hour dietary recall (ASA24) in the 2nd trimester...
November 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29102139/short-communication-supplementation-of-colostrum-and-milk-with-5-hydroxy-l-tryptophan-affects-immune-factors-but-not-growth-performance-in-newborn-calves
#5
Lorenzo E Hernández-Castellano, Ranya Özçelik, Laura L Hernandez, Rupert M Bruckmaier
In ruminants, colostrum is the main source of immunoglobulins for the newborn animal, conferring immune protection until the immune system becomes active and able to synthesize its own immunoglobulins. Serotonin (5-HT), a biogenic amine derived from tryptophan, has stimulatory effects on many physiological processes, including components of the innate (mastocytes, eosinophils, and natural killer cells) and adaptive (T and B lymphocytes) immune systems. Based on the known effects of 5-HT on the immune system, we hypothesized that increased concentrations of 5-HT, through administration of its precursor 5-hydroxy-l-tryptophan (5-HTP), may positively affect development of the calf's immune system and therefore support health and growth performance during the first weeks of life...
October 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29093983/the-importance-of-magnesium-in-clinical-healthcare
#6
REVIEW
Gerry K Schwalfenberg, Stephen J Genuis
The scientific literature provides extensive evidence of widespread magnesium deficiency and the potential need for magnesium repletion in diverse medical conditions. Magnesium is an essential element required as a cofactor for over 300 enzymatic reactions and is thus necessary for the biochemical functioning of numerous metabolic pathways. Inadequate magnesium status may impair biochemical processes dependent on sufficiency of this element. Emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for magnesium, a deficiency problem contributing to various health conditions...
2017: Scientifica
https://www.readbyqxmd.com/read/29090711/the-effect-of-dietary-magnesium-and-caseinphosphopeptides-on-bone-metabolism-in-rats
#7
Guo Liu, Jianyin Miao, Shengwei Sun, Zhen Luo, Zumeng Xia, Baoyan Guo, Fei Liu, Yunjiao Chen, Danyang Ying, Benchun Miao, Yong Cao
The effect of dietary magnesium (Mg) or caseinphosphopeptides (CPPs) on bone metabolism has been reported. However, few studies have investigated the effects of simultaneous supplementation of Mg and CPPs. Sixty-three 3-week-old Sprague-Dawley male rats were divided into seven groups and fed a specified diet for 45 days. Body characteristics, bone physicochemical indicators, and bone metabolism indicators relative to bone metabolism were analyzed. We found that, first, a dietary Mg deficiency resulted in increased bone formation and decreased bone resorption...
November 1, 2017: Food & Function
https://www.readbyqxmd.com/read/29090120/magnesium-stearate-a-widely-used-food-additive-exhibits-a-lack-of-in-vitro-and-in-vivo-genotoxic-potential
#8
Cheryl A Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-Mo Hayashi
Magnesium stearate is widely used in the production of dietary supplement and pharmaceutical tablets, capsules and powders as well as many food products, including a variety of confectionery, spices and baking ingredients. Although considered to have a safe toxicity profile, there is no available information regarding its potential to induce genetic toxicity. To aid safety assessment efforts, magnesium sulfate was evaluated in a battery of tests including a bacterial reverse mutation assay, an in vitro chromosome aberration assay, and an in vivo erythrocyte micronucleus assay...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29077944/association-of-serum-magnesium-with-all-cause-mortality-in-patients-with-and-without-chronic-kidney-disease-in-the-dallas-heart-study
#9
Silvia Ferrè, Xilong Li, Beverley Adams-Huet, Naim M Maalouf, Khashayar Sakhaee, Robert D Toto, Orson W Moe, Javier A Neyra
Background: Low serum magnesium (SMg) has been linked to increased mortality and cardiovascular disease (CVD) in the general population. We examined whether this association is similar in participants with versus without prevalent chronic kidney disease (CKD) in the multiethnic Dallas Heart Study (DHS) cohort. Methods: SMg was analyzed as a continuous variable and divided into tertiles. Study outcomes were all-cause death, cardiovascular (CV) death or event, and CVD surrogate markers, evaluated using multivariable Cox regression models adjusted for demographics, comorbidity, anthropometric and biochemical parameters including albumin, phosphorus and parathyroid hormone, and diuretic use...
October 25, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29075585/comparison-of-serum-magnesium-levels-in-overweight-and-obese-children-and-normal-weight-children
#10
Syed Awais Ul Hassan, Iftikhar Ahmed, Adeel Nasrullah, Shujaul Haq, Haider Ghazanfar, Abu Baker Sheikh, Rizwan Zafar, Ghazan Askar, Zamara Hamid, Arshad Khushdil, Amna Khan
Purpose Abnormalities in serum magnesium levels have been seen in obesity and its related diseases. Our aim is to determine the mean magnesium levels in overweight and obese children as compared to the levels in normal weight controls to study its relationship with obesity and overweight. The study was done at a tertiary care hospital. Methods A case-control study was conducted at the Department of Pediatrics, Combined Military Hospital, Peshawar, over a 12-month period from August 7, 2015 to August 6, 2016...
August 24, 2017: Curēus
https://www.readbyqxmd.com/read/29075541/unusual-complication-of-multidrug-resistant-tuberculosis
#11
Prerna Sharma, Ravindra Nath Sahay
INTRODUCTION: Capreomycin is a second-line drug often used for multidrug-resistant tuberculosis which can result in nephrotoxic effects similar to other aminoglycosides. We describe a case of capreomycin induced Bartter-like syndrome with hypocalcemic tetany. CASE REPORT: 23-year-old female patient presented with carpopedal spasms and tingling sensations in hands. Patient was being treated with capreomycin for two months for tuberculosis. On further investigation, hypocalcemia, hyponatremia, hypomagnesemia, hypokalemia, and hypochloremic metabolic alkalosis were noted...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29063671/magnesium-supplementation-a-consideration-in-dialysis-patients
#12
EDITORIAL
Mugurel Apetrii, Adrian Covic, Ziad A Massy
Even though disorders of magnesium (Mg) balance are common in dialyzed patients, this cation is often neglected. Many factors interfere with serum magnesium including diet, medications (eg, antacids or phosphate binders), and the dialysis prescription. Mg supplementation may help reduce serum phosphate concentration, PTH, and interfere with vascular calcification and bone mineralization. It could also decrease the all-cause and cardiovascular mortalities, although the results of current studies are conflicting...
October 23, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/29062181/micronutrients-drift-during-daily-and-weekly-iron-supplementation-in-non-anaemic-and-anaemic-pregnancy
#13
Hari Shankar, Neeta Kumar, Rajat Sandhir, Suneeta Mittal, Tulsi Adhikari, Arun Kumar, D N Rao
AIMS: Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29056894/magnesium-bioavailability-from-mineral-waters-with-different-mineralization-levels-in-comparison-to-bread-and-a-supplement
#14
Inga Schneider, Theresa Greupner, Andreas Hahn
The aim of the present study was to compare the magnesium bioavailability from four mineral waters with different types of mineralization (e.g. SO4(2-), HCO3(-), calcium) with the magnesium bioavailability from bread and from a magnesium supplement. A single-center, randomized, controlled trial with a crossover design with 22 healthy men and women was conducted at the Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany. The participants consumed the six test products providing 100 mg of magnesium each on six examination days with a one-week washout phase in between...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29055421/magnesium-as-a-new-player-in-ckd-too-little-is-as-bad-as-too-much
#15
Naoto Hamano, Hirotaka Komaba, Masafumi Fukagawa
Vascular calcification is a serious complication of chronic kidney disease, but the current therapeutic strategy is insufficient for preventing its progression. Magnesium is a potent inhibitor of calcification and represents a promising therapeutic candidate. Diaz-Tocados and colleagues now demonstrate that magnesium supplementation prevents the progression of vascular calcification in a uremic rat model, independently of the phosphate-binding capacity. We should keep in mind, however, that too much magnesium could have adverse effects on bone metabolism...
November 2017: Kidney International
https://www.readbyqxmd.com/read/29038735/enrichment-of-milk-with-magnesium-provides-healthier-and-safer-dairy-products
#16
Noa Ben-Ishay, Hilla Oknin, Doron Steinberg, Zipi Berkovich, Ram Reifen, Moshe Shemesh
Biofilms on the surfaces of milk-processing equipment are often a major source of contamination of dairy products. Members of the genus Bacillus appear to be among the most commonly found bacteria in dairy farms and processing plants. Bacillus species may thrive in dairy farm equipment and in dairy products since they can form robust biofilms during growth within milk. We found that fortification of milk with magnesium mitigated biofilm formation by Bacillus species, and thus could notably reduce dairy product spoilage...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29037423/unique-ecg-presentations-and-clinical-management-of-a-symptomatic-lqt2-female-carrying-a-novel-de-novo-kcnh2-mutation
#17
Chunlin Yin, Ping Zhang, Jing Yang, Li Zhang
A 26-year-old woman, 12 days in postpartum, developed recurrent syncope and cardiac arrest. Her ECG revealed QT-prolongation associated with LQT2-specific T-U wave patterns, T wave alternans, long QT-dependent torsade de pointes (TdP) and ventricular fibrillation (VF). She also had intermittent LBBB (80bpm) on alternate beats and RBBB at sinus tachycardia (113bpm). Family genotyping revealed a novel de novo missense mutation G604C of KCNH2. Propranolol slowed heart rate and further prolonged QT interval (610ms) that caused TdP recurrence...
August 17, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29036357/chronic-magnesium-deficiency-and-human-disease-time-for-reappraisal
#18
Adel A A Ismail, Yasmin Ismail, Abbas A Ismail
Numerous epidemiological, experimental and clinical studies over the last 30 years have consistently shown that chronic magnesium deficiency is associated with and/or exacerbates a number of major disorders (table 1). Yet chronic magnesium deficiency is not widely recognised and a major reason for this failure is that serum magnesium levels do not accurately reflect body magnesium stores. Specifically, in chronic magnesium deficiency, serum magnesium levels are often within the normal reference range (usually lowest quartile) and may not progress to overt hypomagnesaemia...
September 22, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29035309/serum-magnesium-levels-in-preterm-infants-are-higher-than-adult-levels-a-systematic-literature-review-and-meta-analysis
#19
REVIEW
Jacques Rigo, Catherine Pieltain, Viola Christmann, Francesco Bonsante, Sissel J Moltu, Silvia Iacobelli, Stéphane Marret
Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of biomacromolecules, bone matrix development, energy production, as well as heart, nerve, and muscle function. Although the importance of Mg is evident, reference values for serum Mg (sMg) in pediatric patients (more specifically, in neonates) are not well established. This systematic literature review and meta-analysis (using 47 eligible studies) aims to quantify normal and tolerable ranges of sMg concentrations during the neonatal period and to highlight the factors influencing Mg levels and the importance of regulating sMg levels during pregnancy and birth...
October 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29034175/refining-low-protein-modular-feeds-for-children-on-low-protein-tube-feeds-with-organic-acidaemias
#20
A Daly, S Evans, C Ashmore, S Chahal, S Santra, A MacDonald
Children with inherited metabolic disorders (IMD) who are dependent on tube feeding and require a protein restriction are commonly fed by 'modular tube feeds' consisting of several ingredients. A longitudinal, prospective two-phase study, conducted over 18 months assessed the long-term efficacy of a pre-measured protein-free composite feed. This was specifically designed to meet the non-protein nutritional requirements of children (aged over 1 year) with organic acidaemias on low protein enteral feeds and to be used as a supplement with an enteral feeding protein source...
December 2017: Molecular Genetics and Metabolism Reports
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