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https://www.readbyqxmd.com/read/29928642/pathophysiology-and-diagnosis-of-pulmonary-hypertension-due-to-left-heart-disease
#1
REVIEW
Athanasios Charalampopoulos, Robert Lewis, Peter Hickey, Charlotte Durrington, Charlie Elliot, Robin Condliffe, Ian Sabroe, David G Kiely
Pulmonary hypertension due to left heart disease (PH-LHD) is the most common type of pulmonary hypertension, although an accurate prevalence is challenging. PH-LHD includes PH due to systolic or diastolic left ventricular dysfunction, mitral or aortic valve disease and congenital left heart disease. In recent years a new and distinct phenotype of "combined post-capillary and pre-capillary PH," based on diastolic pulmonary gradient and pulmonary vascular resistance, has been recognized. The roles of right ventricular dysfunction and pulmonary vascular compliance in PH-LHD have also been elucidated recently and they appear to have significant clinical implications...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29928521/pulmonary-rehabilitation-in-patients-with-an-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#2
REVIEW
Sarah E Jones, Ruth E Barker, Claire M Nolan, Suhani Patel, Matthew Maddocks, William D C Man
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are one of the most common causes of emergency hospital admission and place great burden upon healthcare systems. Furthermore, AECOPD represent an important life event for patients, and are associated with significant reductions in physical activity, skeletal muscle function, exercise tolerance and health-related quality of life. Pulmonary rehabilitation, an intervention comprising supervised exercise-training and education, may counteract these negative consequences and target modifiable risk factors for hospital readmission...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928127/isolated-proximal-greater-saphenous-vein-thrombosis-and-the-risk-of-propagation-to-deep-vein-thrombosis-and-pulmonary-embolism
#3
Samuel H Kim, Nimesh Patel, Kanika Thapar, Ananda V Pandurangadu, Amit Bahl
Objectives: Greater saphenous vein (GSV) thrombosis is concerning due to its close proximity to the deep femoral vein. This study sought to identify the risk of propagation to deep vein thrombosis (DVT) or pulmonary embolism (PE) among patients with isolated proximal GSV superficial thrombosis and describe provider practice patterns related to treatment. Materials and methods: This is an Institutional Review Board-approved retrospective multi-center study. Patients presented to one of three possible emergency departments in a large health system...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29926563/-acute-heart-failure-and-acute-pulmonary-edema
#4
V D'orio, A Ancion, P Lancellotti
Acute heart failure is a common cause of admission in emergency department. Management requires rapid support when haemodynamic or respiratory parameters are altered. Identifying enabling factors and their specific treatment is an integral part of management. The most common clinical presentation is volume overload, whose treatment remains the combination of diuretics and vasodilators. In case of impaired perfusion, various inotropic supports may be considered, but also more and more circulatory assistance devices...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29926123/respiratory-complications-after-colorectal-surgery-avoidable-or-fate
#5
Jonas Jurt, Martin Hübner, Basile Pache, Dieter Hahnloser, Nicolas Demartines, Fabian Grass
BACKGROUND: The prevention of post-operative pulmonary complications (PPC) is targeted by several enhanced recovery (ERAS) items including early mobilisation, prevention of fluid overload and omission of routine nasogastric tubes. The aim of the present study was to assess the impact of ERAS on PPC. METHODS: This was a retrospective analysis of an institutional database including consecutive colorectal ERAS procedures from May 2011 until May 2017. Multiple logistic regressions were performed to identify risk factors for PPC among demographic, surgical characteristics and items related to the ERAS protocol...
June 20, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29925836/identifying-patients-with-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-using-latent-class-analysis-of-electronic-health-record-data-a-study-protocol
#6
Mohammad A Al Sallakh, Sarah E Rodgers, Ronan A Lyons, Aziz Sheikh, Gwyneth A Davies
Asthma and chronic obstructive pulmonary disease (COPD) are two common different clinical diagnoses with overlapping clinical features. Both conditions have been increasingly studied using electronic health records (EHR). Asthma-COPD overlap syndrome (ACOS) is an emerging concept where clinical features from both conditions co-exist, and for which, however, there is no consensus definition. Nonetheless, we expect EHR data of people with ACOS to be systematically different from those with "asthma only" or "COPD only"...
June 20, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29922895/benefits-of-the-tranexamic-acid-in-head-trauma-with-no-extracranial-bleeding-a-prospective-follow-up-of-180-patients
#7
Olfa Chakroun-Walha, Amal Samet, Mouna Jerbi, Abdennour Nasri, Aziza Talbi, Hassen Kanoun, Basma Souissi, Kamilia Chtara, Mounir Bouaziz, Hichem Ksibi, Noureddine Rekik
INTRODUCTION: Tranexamic acid (TXA) is one of the debated therapies in the management of traumatic brain injury (TBI). We conducted this study to evaluate the benefits of TXA in TBI on the mortality and its safety in these patients. METHODS: This was a prospective randomized open-label trial including all patients, aged at 18 years or older, hospitalized in the emergency room during a 13-month period, for TBI. After the realization of the body CT scan, the patients were included if they had intracranial bleeding, and were then randomized according to their medical file number to receive or not the TXA...
June 19, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29922521/misled-by-the-air-pneumocephalus
#8
Koin Lon Shum, Yuyang Tan
Pneumocephalus, the presence of air within the cranium, commonly suggests a breach in the meningeal layer or an intracranial infection by a gas-producing organism. Trauma is the most common cause of pneumocephalus, followed by cranial surgery. Other causes include infection and intracranial neoplasm. An 87-year-old man was conveyed to the emergency department after being found to be drowsy by his helper. He was noted to have a new onset right-sided hemiparesis. Past medical history was significant for hypertension, stage 5 chronic kidney disease, cerebrovascular accident, pacemaker insertion for sick sinus syndrome, transurethral resection of the prostate for benign prostatic hyperplasia, and pulmonary tuberculosis...
April 14, 2018: Curēus
https://www.readbyqxmd.com/read/29921083/-wegner-s-granulomatosis-of-hypolarynx-in-a-patient-with-laryngemphraxis-case-report-and-review-of-literature
#9
L L Shi, H T Zhen
Summary A patient suffered from progressive dyspnea and even laryngeal obstruction visited our department in May, 2017 and received emergency tracheotomy for assistance in breathing. There was no dysphagia, sore throat, fever, cough, hemoptysis and hematuresis. The pathological signs including facies dolorosa, three depressions sign, perforation of nasal septum. The laboratory examination showed that there were hematuresis and albuminuria. The urine bilirubin levels were elevated, antineutrophil cytoplasmic antibody (ANCA) was positive and antiproteinase 3 antibody was elevated...
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29920858/the-epidemiology-of-tuberculosis-in-the-rural-balimo-region-of-papua-new-guinea
#10
Tanya Diefenbach-Elstob, Patricia Graves, Robert Dowi, Bisato Gula, David Plummer, Emma McBryde, Daniel Pelowa, Peter Siber, William Pomat, Jeffrey Warner
OBJECTIVE: Papua New Guinea (PNG) has an emerging tuberculosis (TB) epidemic which has become a national public health priority. In Western Province, there are few data about TB outside Daru and the South Fly District. This study describes the epidemiology of TB diagnosed at Balimo District Hospital (BDH) in the Middle Fly District of Western Province, PNG. METHODS: All patients (n=1614) diagnosed with TB at BDH from April 2013 to February 2017 were recorded. Incidence of reported new cases was calculated for the combined Balimo Urban and Gogodala Rural local level government areas...
June 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29916860/the-las-vegas-risk-score-for-prediction-of-postoperative-pulmonary-complications-an-observational-study
#11
Ary Serpa Neto, Luiz Guilherme V da Costa, Sabrine N T Hemmes, Jaume Canet, Göran Hedenstierna, Samir Jaber, Michael Hiesmayr, Markus W Hollmann, Gary H Mills, Marcos F Vidal Melo, Rupert Pearse, Christian Putensen, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz
BACKGROUND: Currently used pre-operative prediction scores for postoperative pulmonary complications (PPCs) use patient data and expected surgery characteristics exclusively. However, intra-operative events are also associated with the development of PPCs. OBJECTIVE: We aimed to develop a new prediction score for PPCs that uses both pre-operative and intra-operative data. DESIGN: This is a secondary analysis of the LAS VEGAS study, a large international, multicentre, prospective study...
June 18, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29915333/impact-of-bronchiectasis-on-outcomes-of-hospitalized-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-a-propensity-matched-analysis
#12
Ernesto Crisafulli, Mónica Guerrero, Antonella Ielpo, Adrian Ceccato, Arturo Huerta, Albert Gabarrús, Néstor Soler, Alfredo Chetta, Antoni Torres
The coexistence of both Chronic Obstructive Pulmonary Disease (COPD) and bronchiectasis (BE) define an emerging phenotype with a worse prognosis; however, data about these patients do not consider baseline characteristics as confounders. We evaluate the impact of BE on outcomes of hospitalized patients with acute exacerbation of COPD (AECOPD). We prospectively considered AECOPD patients, analysed using a propensity score matching (PSM) method. The outcomes included length of hospital stay, use of non-invasive and invasive mechanical ventilation, intensive care unit admission, and mortality up to 3-years...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29911017/free-floating-right-heart-thrombus-with-acute-massive-pulmonary-embolism-a-case-report-and-review-of-the-literature
#13
Fida Charif, Mohamad Jihad Mansour, Righab Hamdan, Claudette Najjar, Pierre Nassar, Mohamad Issa, Elie Chammas, Mohamad Saab
Free-floating right heart thrombus (RHT) is an extreme medical emergency in the context of acute massive pulmonary embolism (PE). Despite the advances in early diagnosis, the management is still very debatable due to lack of consensus. We reported the case of a 66-year-old male, with a history of moderate renal dysfunction and dilated cardiomyopathy, who presented to the emergency department for acute dyspnea. His angiographic magnetic resonance imaging revealed bilateral extensive PE. Transthoracic echocardiography showed RHT with moderate right ventricular dysfunction and pulmonary hypertension...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29907106/activation-and-polarization-of-circulating-monocytes-in-severe-chronic-obstructive-pulmonary-disease
#14
William D Cornwell, Victor Kim, Xiaoxuan Fan, Marie Elena Vega, Frederick V Ramsey, Gerard J Criner, Thomas J Rogers
BACKGROUND: The ability of circulating monocytes to develop into lung macrophages and promote lung tissue damage depends upon their phenotypic pattern of differentiation and activation. Whether this phenotypic pattern varies with COPD severity is unknown. Here we characterize the activation and differentiation status of circulating monocytes in patients with moderate vs. severe COPD. METHODS: Blood monocytes were isolated from normal non-smokers (14), current smokers (13), patients with moderate (9), and severe COPD (11)...
June 15, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29906040/atypical-clinical-presentation-of-flavivirus-case-report
#15
Rodrigo Gopar-Nieto, Nancy Libertad Chávez-Gómez, María Elisa González-Rentería, Luis Adrián Estrada-Loyo, Roberto de Jesús García-Avilés, Carlos Lenin Pliego-Reyes
The first report of chikungunya virus (CHIKV) in Mexico was in may 2014, in Jalisco, and has disseminated along the country in such a way that now is considered a relevant emergent vector-transmitted infection. It is clinically diagnosed by abrupt onset fever, asthenia, arthralgias, myalgias, headache and rash. In the clinical case, we described a women from Guerrero that had pulmonary symptomatology associated to CHIKV, which is an atypical clinical presentation that has been reported only in a hundred cases worldwide...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29904902/acute-appendicitis-caused-by-metastatic-adenocarcinoma-from-the-lung-a-case-report
#16
Yusuke Kimura, Takafumi Machimoto, Daiki Yasukawa, Yuki Aisu, Tomohide Hori
BACKGROUND: Appendiceal metastasis from lung cancer is rare. However, it often causes acute appendicitis that requires emergency surgery. We herein report a thought-provoking case of appendiceal metastasis from lung cancer. CASE PRESENTATION: A 71-year-old man was diagnosed with advanced lung cancer with multiple metastases and underwent chemotherapy. One month later, he developed acute appendicitis, and laparoscopic appendectomy was promptly performed. A swollen appendix and pus collection were observed during surgery...
June 15, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29904593/case-report-pulmonary-and-liver-sarcoidosis-suspected-of-metastasis
#17
Behnam Jafari, Gholamabas Sabz, Elahe Masnavi, Roghaye Panahi, Saeid Jokar, Amrollah Roozbehi, Sajad Hasanzadeh
Introduction : Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Case report : A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment...
2018: F1000Research
https://www.readbyqxmd.com/read/29904437/-mycoplasma-pneumoniae-a-potentially-severe-infection
#18
REVIEW
Bharat Bajantri, Sindhaghatta Venkatram, Gilda Diaz-Fuentes
Mycoplasma pneumoniae infections remain one of the most common etiologies of community-acquired pneumonia (CAP). The clinical presentation and manifestations vary widely and can affect all organs of the body. Diagnosis is challenging because there are no constant findings in physical exams or laboratory or radiological assessments that indicate Mycoplasma pneumoniae pneumonia, and specific diagnostic tools are not readily available. Extrapulmonary manifestations and severe pulmonary manifestations can lead to long-term sequelae...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904352/pulmonary-arterial-hypertension-iron-matters
#19
REVIEW
Latha Ramakrishnan, Sofia L Pedersen, Quezia K Toe, Gregory J Quinlan, Stephen J Wort
The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes. Recently, associations between disrupted iron homeostasis and pulmonary artery hypertension (PAH) have been described with the suggestion that there is a contributory link with disease...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29903859/how-to-build-a-lung-latest-advances-and-emerging-themes-in-lung-bioengineering
#20
Martina M De Santis, Deniz A Bölükbas, Sandra Lindstedt, Darcy E Wagner
Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation...
June 14, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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