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https://www.readbyqxmd.com/read/28944909/long-non%C3%A2-coding-rna-associated%C3%A2-competing-endogenous-rnas-are-induced-by-clusterin-in-retinal-pigment-epithelial-cells
#1
Zi Ye, Zhaohui Li, Shouzhi He
Age related macular degeneration is one of the most common causes of vision loss in the elderly. Long noncoding RNAs (lncRNAs) serve important roles in regulating gene expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of specific lncRNAs and their associated ceRNA function induced by clusterin in cultured retinal pigment epithelial (RPE) cells remain to be fully elucidated. Based on high throughput sequencing data from RPE cells treated with or without clusterin, the present study identified differentially expressed mRNAs, lncRNAs and microRNAs (miRNAs)...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944307/posterior-pole-retinal-detachment-due-to-a-macular-hole-in-a-patient-with-a-boston-keratoprosthesis
#2
Daniel Gologorsky, Basil K Williams, Harry W Flynn
PURPOSE: To describe the clinical course of a patient with a Boston Keratoprosthesis type I who developed a localized posterior pole retinal detachment secondary to a macular hole. OBSERVATIONS: A 73-year-old patient with a Boston Keratoprosthesis developed a localized posterior pole retinal detachment secondary to a macular hole. The retinal detachment was repaired with a 23-gauge pars plana vitrectomy, membrane peel, fluid-air exchange and 18% C3F8. Retinal reattachment was achieved but the macular hole remained open...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/28944213/comment-on-predictors-of-short-term-outcomes-related-to-central-subfield-foveal-thickness-after-intravitreal-bevacizumab-for-macular-edema-due-to-central-retinal-vein-occlusion
#3
Dan Călugăru, Mihai Călugăru
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944207/predictive-factors-of-visual-outcome-of-malaysian-cataract-patients-a-retrospective-study
#4
Thanigasalam Thevi, Myron Anthony Godinho
AIM: To explore the associations between various characteristics of Malaysian cataract patients and their management, and their post-operative visual outcomes, to inform relevant bodies to reduce cataract-related blindness. METHODS: We conducted a descriptive secondary data analysis of cataract surgery patients in Melaka Hospital, from 2007 to 2014 using the National Eye Database (NED). Patient-related factors (demographic features, systemic and ocular comorbidities) and management-related factors (surgical duration, type of surgery, type of lens) were analysed for their association with visual outcome (acuity)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944191/mmp-2-rs24386-c-t-gene-polymorphism-and-the-phenotype-of-age-related-macular-degeneration
#5
Rasa Liutkeviciene, Vaiva Lesauskaite, Giedre Sinkunaite-Marsalkiene, Sandrita Simonyte, Reda Zemaitiene, Loresa Kriauciuniene, Dalia Zaliuniene
AIM: To examine the MMP-2 (-1306 C/T) gene polymorphism and the phenotype characterized by soft and hard drusen of early age-related macular degeneration (AMD) and geographic atrophy of late AMD form. METHODS: The study enrolled 850 investigations (290 AMD patients with soft and hard drusen, 34 with geographic atrophy and a random sample of the population n=526). Early AMD was classified according to the International Classification and Grading System. For geographic atrophy diagnosis the Age-Related Eye Disease Study classification was used...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28943729/docking-analysis-of-verteporfin-with-yap-ww-domain
#6
Ilham Kandoussi, Wiame Lakhlili, Jamal Taoufik, Azeddine Ibrahimi
The YAP oncogene is a known cancer target. Therefore, it is of interest to understand the molecular docking interaction of verteporfin (a derivative of benzo-porphyrin) with the WW domain of YAP (clinically used for photo-dynamic therapy in macular degeneration) as a potential WW domain-ligand modulator by inhibition. A homology protein SWISS MODEL of the human YAP protein was constructed to dock (using AutoDock vina) with the PubChem verteporfin structure for interaction analysis. The docking result shows the possibilities of verteporfin interaction with the oncogenic transcription cofactor YAP having WW1 and WW2 domains...
2017: Bioinformation
https://www.readbyqxmd.com/read/28943693/evaluation-of-a-clinical-decision-making-aid-for-nutrition-advice-in-age-related-macular-degeneration
#7
Rebekah Stevens, Hannah Bartlett, Richard Cooke
Age-related macular disease (AMD) is a multifactorial degenerative condition affecting the central area of the retina. Patients with AMD report that eye care practitioners are not giving consistent advice regarding nutrition and reported confusion as to what advice, if any, to follow. The aim of this study was to design and conduct a preliminary evaluation of a flowchart to support eye care practitioners in providing accurate, evidence-based nutritional advice to their patients. A flowchart was designed to take practitioners through a decision-making process that would determine whether a patient matched the Age-Related Eye Disease Study (AREDS) 2 eligibility criteria for supplementation...
September 2017: British Journal of Visual Impairment
https://www.readbyqxmd.com/read/28943268/regulated-efflux-of-photoreceptor-outer-segment-derived-cholesterol-by-human-rpe-cells
#8
Federica Storti, Gabriele Raphael, Vera Griesser, Katrin Klee, Faye Drawnel, Carolin Willburger, Rebecca Scholz, Thomas Langmann, Arnold von Eckardstein, Jürgen Fingerle, Christian Grimm, Cyrille Maugeais
Genetic studies have linked age-related macular degeneration (AMD) to genes involved in high-density lipoprotein (HDL) metabolism, including ATP-binding cassette transporter A1 (ABCA1). The retinal pigment epithelium (RPE) handles large amounts of lipids, among others cholesterol, partially derived from internalized photoreceptor outer segments (OS) and lipids physiologically accumulate in the aging eye. To analyze the potential function of ABCA1 in the eye, we measured cholesterol efflux, the first step of HDL generation, in RPE cells...
September 21, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28942521/imaging-of-tangential-traction-types-in-lamellar-macular-holes
#9
Alessandra Acquistapace, Matteo Giuseppe Cereda, Mario Cigada, Giovanni Staurenghi, Ferdinando Bottoni
PURPOSE: To determine the best imaging procedure for the definition of tangential tractions generated by epiretinal membranes in lamellar macular holes. METHODS: Inclusion criteria were a diagnosis of lamellar macular hole with tractional epiretinal membranes based upon fundus autofluorescence (FAF), and spectral-domain optical coherence tomography (SD-OCT) imaging (HRA + OCT Spectralis, Heidelberg Engineering, Heidelberg, Germany). Tangential tractions were evaluated with infrared reflectance (IR; 820 nm) and OCT en face (193 B-scans, 30 × 20°pattern size, 31 μm between two consecutive B-scans)...
September 23, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28941979/proteolytic-degradation-and-inflammation-play-critical-roles-in-polypoidal-choroidal-vasculopathy
#10
Sandeep Kumar, Hiroyuki Nakashizuka, Alex Jones, Alyssia Lambert, Xuchen Zhao, Megan Shen, Mackenzie Parker, Shixian Wang, Zachary Berriochoa, Amrita Fnu, Stephanie VanBeuge, Patricia Chévez-Barrios, Mark Tso, Jon Rainier, Yingbin Fu
Polypoidal choroidal vasculopathy (PCV) is a common subtype of wet age-related macular degeneration (AMD) in Asian populations while choroidal neovascularization (CNV) is the typical subtype in Western populations. The etiology of PCV is unknown. By comparing the phenotype of a PCV mouse model expressing protease HTRA1 in retinal pigment epithelium with transgenic mice expressing the inactive HTRA1(S328A), we showed that HTRA1 mediated degradation of elastin in choroidal vessels is critical for the development of PCV, which exhibited destructive extracellular matrix remodeling and vascular smooth muscle cell loss...
September 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28941524/juvenile-macular-degenerations
#11
Pablo Altschwager, Lucia Ambrosio, Emily A Swanson, Anne Moskowitz, Anne B Fulton
In this article, we review the following 3 common juvenile macular degenerations: Stargardt disease, X-linked retinoschisis, and Best vitelliform macular dystrophy. These are inherited disorders that typically present during childhood, when vision is still developing. They are sufficiently common that they should be included in the differential diagnosis of visual loss in pediatric patients. Diagnosis is secured by a combination of clinical findings, optical coherence tomography imaging, and genetic testing...
May 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28940022/impairment-of-autoregulation-of-optic-nerve-head-blood-flow-during-vitreous-surgery-in-patients-with-hypertension-and-hyperlipidemia
#12
Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka, Takatoshi Maeno
PURPOSE: To examine whether hypertension (HTN) and hyperlipidemia (HL) affect autoregulation of optic nerve head (ONH) blood flow during vitrectomy. DESIGN: Cohort study. METHODS: Seventeen eyes from 17 subjects with HTN and HL and 19 eyes from 19 control subjects without systemic disorders underwent vitrectomy for the treatment of epiretinal membrane or macular hole. Following standard 25-gauge microincision vitrectomy, the mean blur rate (MBR), which is an index of relative ONH blood flow, in the vascular area (vascular MBR) and MBR in the tissue area (tissue MBR) were measured using laser speckle flowgraphy...
September 23, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28939808/novel-pathogenic-mutations-in-c1qtnf5-support-a-dominant-negative-disease-mechanism-in-late-onset-retinal-degeneration
#13
Chloe M Stanton, Shyamanga Borooah, Camilla Drake, Joseph A Marsh, Susan Campbell, Alan Lennon, Dinesh C Soares, Neeru A Vallabh, Jayashree Sahni, Artur V Cideciyan, Baljean Dhillon, Veronique Vitart, Samuel G Jacobson, Alan F Wright, Caroline Hayward
Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual loss. L-ORD shows striking phenotypic similarities to age-related macular degeneration (AMD), a common and genetically complex disorder, which can lead to misdiagnosis in the early stages. To date, a single missense mutation (S163R) in the C1QTNF5 gene, encoding C1q And Tumor Necrosis Factor Related Protein 5 (C1QTNF5) has been shown to cause L-ORD in a subset of affected families...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28937877/changes-in-peripapillary-nerve-fiber-layer-thickness-after-adjuvant-stereotactic-radiotherapy-in-patients-with-neovascular-age-related-macular-degeneration
#14
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
PURPOSE: To evaluate the effect of stereotactic radiotherapy (SRT) in conjunction with intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) drugs on peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with neovascular age-related macular degeneration (nAMD). METHODS: This was a retrospective, observational case series of patients with nAMD, who underwent SRT and subsequently had at least 12 months of complete follow-up...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937833/oct-angiography-for-monitoring-and-managing-neovascular-age-related-macular-degeneration
#15
P Malamos, G Tsolkas, M Kanakis, G Mylonas, D Karatzenis, N Oikonomopoulos, J Lakoumentas, Ilias Georgalas
PURPOSE: To evaluate the combined use of optical coherence tomography and angiography (OCT-A) for imaging choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration (nAMD). MATERIALS AND METHODS: This prospective observational study was conducted from May 2015 to April 2017. Included in the study were 54 patients (n = 63 eyes), all of whom had CNV secondary to nAMD and all of whom had been examined by OCT-A. Angioscans (3x3 and 6 × 6) and conventional B-scan OCT scans were obtained for all patients at baseline and at various times during the 24-month follow-up period...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937826/choroidal-variations-in-diabetic-macular-edema-fluorescein-angiography-and-optical-coherence-tomography
#16
Xiangning Wang, Shuting Li, Wei Li, Yanjun Hua, Qiang Wu
PURPOSES: To (i) evaluate variations in choroidal thickness (CT) and choroidal volume (CV) in diabetic macular edema (DME), as demonstrated by fluorescein angiography (FA) and enhanced depth-imaging (EDI) optical coherence tomography (OCT) (EDI-OCT) and (ii) correlate these variations with visual acuity. METHODS: This study was a retrospective observational case series of patients with diabetic retinopathy (DR) and DME. The study groups comprised 77 DR patients (n = 87), all of whom underwent color fundus photography, FA, and OCT on the same day...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937527/relationship-between-obstructive-sleep-apnea-and-the-presence-and-severity-of-diabetic-retinopathy
#17
Aimee C Chang, Timothy P Fox, Shutao Wang, Albert Y Wu
PURPOSE: To evaluate the relationship between obstructive sleep apnea (OSA) and the presence and severity of diabetic retinopathy (DR). METHODS: Three hundred seventeen patients with International Classification of Diseases diagnoses of both DR and OSA were evaluated retrospectively. Diabetic retinopathy severity and diabetic macular edema status were determined by diagnostic coding and medical records. Obstructive sleep apnea severity and additional sleep measures were obtained from overnight polysomnography...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28937147/comparison-of-effectiveness-and-safety-between-conbercept-and-ranibizumab-for-treatment-of-neovascular-age-related-macular-degeneration-a-retrospective-case-controlled-non-inferiority-multiple-center-study
#18
J Cui, D Sun, H Lu, R Dai, L Xing, H Dong, L Wang, D Wei, B Jiang, Y Jiao, M M Jablonski, S Charles, W Gu, H Chen
PurposeTo compare the efficacy and safety of conbercept and ranibizumab when administered according to a treat-and-extend (TREX) protocol for the treatment of neovascular age-related macular degeneration (AMD) in China.Patients and methodsBetween May 2014 and May 2015, 180 patients were treated in a 1 : 1 ratio using conbercept or ranibizumab from four hospitals. Patients received either conbercept 0.5 mg or ranibizumab 0.5 mg intravitreal injections. Follow-up time was 1 year and treated based on a TREX approach...
September 22, 2017: Eye
https://www.readbyqxmd.com/read/28936059/a-case-of-unilateral-retinitis-pigmentosa-associated-with-full-thickness-macular-hole
#19
Lama Enani, Igor Kozak, Ehab Abdelkader
A 44-year-old Saudi female presented with poor right eye vision for 3 years. Visual acuity (VA) was 20/400 in the right eye and 20/20 in the left eye. Examination and imaging showed all the typical features of retinitis pigmentosa in the right eye associated with full thickness macular hole (FTMH) and an essentially normal left eye. The case underwent pars plana vitrectomy with internal limiting membrane peeling and gas tamponade that resulted in anatomical closure of the FTMH, but VA remained the same.
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28935399/optical-coherence-tomography-biomarkers-as-functional-outcome-predictors-in-diabetic-macular-edema-treated-with-dexamethasone-implant
#20
Dinah Zur, Matias Iglicki, Catharina Busch, Alessandro Invernizzi, Miriana Mariussi, Anat Loewenstein
PURPOSE: Identification and characterization of patients with diabetic macular edema (DME) are important for individualizing treatment and optimizing outcome. We investigated optical coherence tomography (OCT) biomarkers for DME treated by intravitreal dexamethasone (DEX) implant. DESIGN: Multicenter, retrospective, observational cohort study. PARTICIPANTS: A total of 299 eyes from 284 patients treated with DEX implant for DME (naïve, n = 209; refractory, n = 90)...
September 18, 2017: Ophthalmology
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