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https://www.readbyqxmd.com/read/29792731/apr3-modulates-oxidative-stress-and-mitochondrial-function-in-arpe-19-cells
#1
Yuan Li, Xuan Zou, Jing Gao, Ke Cao, Zhihui Feng, Jiankang Liu
Impairment of retinal pigment epithelial (RPE) cells is considered a key contributor to the development of age-related macular degeneration. Apoptosis-related protein 3 (APR3) was recently discovered after treatment with all- trans retinoic acid, a pivotal molecule in RPE cells. However, the function of APR3 remains poorly understood. In the present study, we found that APR3 could interact with nuclear factor (erythroid-derived 2)-like 2, which is a regulator of phase II enzymes, and that knockdown of APR3 promoted nuclear factor (erythroid-derived 2)-like 2 nuclear translocation and activated expression of phase II enzymes, which was accompanied by improved redox status and mitochondrial activity...
May 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29791040/presence-of-chronic-diabetic-foot-ulcers-is-associated-with-more-frequent-and-more-advanced-retinopathy
#2
A Sellman, P Katzman, S Andreasson, M Löndahl
AIMS: To clarify the frequency and severity of diabetic retinopathy in a group of people with Type 2 diabetes and chronic diabetic foot ulcers, and to compare visual acuity, levels of retinopathy and clinical significant macular oedema with a matched control group of people with Type 2 diabetes without a history of chronic diabetic foot ulcers. METHODS: Visual acuity and fundus imaging were evaluated in 90 white people with at least 3 months' duration of full-thickness diabetic foot ulcers below the ankle and the results compared with those in 180 white people with Type 2 diabetes without a history of chronic diabetic foot ulcers (control group)...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790265/lipid-lowering-medication-use-is-associated-with-decreased-risk-of-diabetic-retinopathy-and-its-treatments-in-patients-with-type-2-diabetes-a-real-world-observational-analysis-of-a-health-claims-database
#3
Ryo Kawasaki, Tsuneo Konta, Kohji Nishida
AIMS: Fenofibrate and statins reduced the risk of diabetic retinopathy (DR) related treatment in clinical trials. We aimed to determine whether lipid-lowering medication use reduce the risk of DR and its treatments in patients with type 2 diabetes using a real-world health claims database. METHODS: This was an observational analysis using a nation-wide health claims database of the Japan Medical Data Center (JMDC). Type 2 diabetes was defined by the ICD-10 codes with glucose-lowering medication use...
May 22, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29789898/-clinical-parameters-of-patients-with-neovascular-age-related-macular-degeneration-longterm-treatment-results-of-an-outpatient-clinic
#4
S Wassel, E Tsompanidi, E Tahmaz, B Hörster, R Hoerster
BACKGROUND: The clinical outcome of neovascular age-related macular degeneration (nAMD) depends on constant follow-up and consistent treatment. Data about the long-term course of intensive anti-vascular endothelial growth factor (VEGF) therapy from outpatient clinics are rare. OBJECTIVE: The aim of the study was to characterize a population of nAMD patients with long-term follow-up and intensive anti-VEGF therapy. PATIENTS AND METHODS: In a supra-regional outpatient clinic, we retrospectively identified patients who had received at least 30 intravitreal anti-VEGF injections and were followed for at least 4 years...
May 22, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29789660/multicolor-tm-imaging-in-combined-hamartoma-of-the-retina-and-retinal-pigment-epithelium
#5
Konstantinos Kaprinis, Hannaa Bobat, Gabriella De Salvo
PURPOSE: To describe the principle characteristics of combined hamartoma of the retina and retinal pigment epithelium ('combined harmatoma') on MultiColorTM imaging and evaluate its role as a diagnostic and management tool. METHODS: Retrospective, observational case series comprising three patients with unilateral, juxtapapillary combined harmatoma. Complete ophthalmic examination was performed. MultiColorTM , including green reflectance (GR) and near infra-red reflectance (NIRR), optical coherence tomography (OCT) and autofluorescence (AF) imaging were obtained (Heidelberg Spectralis)...
May 23, 2018: Eye
https://www.readbyqxmd.com/read/29789659/comparison-of-glaucoma-diagnostic-ability-between-wide-field-swept-source-oct-retinal-nerve-fiber-layer-maps-and-spectral-domain-oct
#6
Won June Lee, Sohee Oh, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To compare the diagnostic ability of wide-field swept-source optical coherence tomography (SS-OCT) retinal nerve fiber layer (RNFL) maps with spectral-domain OCT (SD-OCT) maps for detection of preperimetric (PPG) and early glaucoma (EG). PATIENTS AND METHODS: One hundred and forty-six eyes, including 37 healthy eyes, 38 eyes with PPG, and 71 eyes with EG, were analyzed. The patients underwent both SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) and wide-field SS-OCT scanning (DRI-OCT-1 Atlantis; Topcon, Tokyo, Japan)...
May 23, 2018: Eye
https://www.readbyqxmd.com/read/29789352/reporting-quality-of-randomised-controlled-trial-abstracts-on-age-related-macular-degeneration-health-care-a-cross-sectional-quantification-of-the-adherence-to-consort-abstract-reporting-recommendations
#7
Christine Baulig, Frank Krummenauer, Berit Geis, Sabrina Tulka, Stephanie Knippschild
OBJECTIVE: To assess the reporting quality of randomised controlled trial (RCT) abstracts on age-related macular degeneration (AMD) healthcare, to evaluate the adherence to the Consolidated Standards of Reporting Trials (CONSORT) statement's recommendations on minimum abstract information and to identify journal characteristics associated with abstract reporting quality. DESIGN: Cross-sectional evaluation of RCT abstracts on AMD healthcare. METHODS: A PubMed search was implemented to identify RCT abstracts on AMD healthcare published in the English language between January 2004 and December 2013...
May 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29788031/autologous-neurosensory-retinal-transplantation-for-unclosed-and-large-macular-holes
#8
Chun Ding, Shengguo Li, Jun Zeng
PURPOSE: The aim of this study was to demonstrate the surgical technique and clinical outcome of autologous neurosensory retinal patch transplantation for recurrent large macular hole (MH)-induced retinal detachment after failed surgery with internal limiting membrane (ILM) removal or transplantation. METHODS: We reviewed 5 patients with recurrent MH-induced retinal detachment after failed surgeries with ILM removal or transplantation who underwent vitrectomy combined with autologous neurosensory retinal patch transplantations and were followed up over 6 months...
May 22, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29787492/dot-motion-perception-in-young-adult-emmetropes-and-myopes
#9
Hui-Ying Kuo, David A Atchison, Katrina Leanne Schmid
SIGNIFICANCE: Central motion perception, as assessed by minimum displacement detection, was reduced in highly myopic eyes. Peripheral motion detection may be influenced by myopia, particularly in the inferior-nasal retina. PURPOSE: Motion discrimination is a complex visual task processed mainly via the magnocellular pathway. We investigated whether it is affected in myopia. METHODS: Ninety young adults aged 18 to 28 years participated: 30 emmetropes (spherical equivalent refractions +1...
May 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29787465/predictive-factors-for-proliferative-vitreoretinopathy-formation-after-uncomplicated-primary-retinal-detachment-repair
#10
Kunyong Xu, Eric K Chin, Steven R Bennett, David F Williams, Edwin H Ryan, Sundeep Dev, Robert A Mittra, Polly A Quiram, John B Davies, David Wilkin Parke, Herbert Culver Boldt, David R P Almeida
PURPOSE: To determine predictive factors of proliferative vitreoretinopathy (PVR) formation after uncomplicated primary retinal detachment repair. METHODS: Retrospective, single-center, case-control study of 74 consecutive patients with (37 eyes) and without (37 eyes) PVR formation after undergoing uncomplicated primary surgery for retinal detachment repair. Logistic regression was used to assess factors associated with PVR formation. RESULTS: Retinal detachment involving the macula was 4...
May 21, 2018: Retina
https://www.readbyqxmd.com/read/29786830/blue-light-filtering-intraocular-lenses-iols-for-protecting-macular-health
#11
REVIEW
Laura E Downie, Ljoudmila Busija, Peter R Keller
BACKGROUND: An intraocular lens (IOL) is a synthetic lens that is surgically implanted within the eye following removal of the crystalline lens, during cataract surgery. While all modern IOLs attenuate the transmission of ultra-violet (UV) light, some IOLs, called blue-blocking or blue-light filtering IOLs, also reduce short-wavelength visible light transmission. The rationale for blue-light filtering IOLs derives primarily from cell culture and animal studies, which suggest that short-wavelength visible light can induce retinal photoxicity...
May 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29786089/spectral-analysis-of-fundus-autofluorescence-pattern-as-a-tool-to-detect-early-stages-of-degeneration-in-the-retina-and-retinal-pigment-epithelium
#12
Tatiana B Feldman, Marina A Yakovleva, Andrey V Larichev, Patimat M Arbukhanova, Alexandra Sh Radchenko, Sergey A Borzenok, Vladimir A Kuzmin, Mikhail A Ostrovsky
PURPOSE: The aim of this work is the determination of quantitative diagnostic criteria based on the spectral characteristics of fundus autofluorescence to detect early stages of degeneration in the retina and retinal pigment epithelium (RPE). METHODS: RPE cell suspension samples were obtained from the cadaver eyes with and without signs of age-related macular degeneration (AMD). Fluorescence analysis at an excitation wavelength of 488 nm was performed. The fluorescence lifetimes of lipofuscin-granule fluorophores were measured by counting time-correlated photon method...
May 22, 2018: Eye
https://www.readbyqxmd.com/read/29786087/a-comparison-of-23-gauge-and-20-gauge-vitrectomy-for-proliferative-sickle-cell-retinopathy-clinical-outcomes-and-surgical-management
#13
Jason Ho, Anna Grabowska, Marta Ugarte, Mahiul Mk Muqit
AIMS: To report anatomical and functional outcomes in patients with proliferative sickle retinopathy (PSR) who underwent 23-gauge (23G) and 20-gauge (20G) vitrectomy. METHODS: Retrospective consecutive case series of patients who underwent vitreoretinal intervention for complications of PSR between April 2009 and February 2015. Operations were performed at a tertiary referral centre, Moorfields Eye Hospital. Visual acuity and anatomical success rates were evaluated for PSR complicated by retinal detachment, tractional vitreous haemorrhage and macular hole...
May 22, 2018: Eye
https://www.readbyqxmd.com/read/29786008/an-unexpected-complication-in-bilateral-acute-iris-transillumination-cystoid-macular-edema
#14
Cigdem Altan, Berna Basarir, Cem Kesim
A 47-year-old male presented with bilateral 4 + circulating pigment in the anterior chamber, diffuse iris transillumination, dilated pupils unresponsive to light, and high intraocular pressure (IOP) levels in both eyes. Visual acuity and IOP improved bilaterally with topical steroid and antiglaucomatous therapy. In the 10th month, bilateral cystoid macular edema (CME) was developed and resolved after subtenon triamcinolone injections. CME recurred after cataract surgery in the right eye which was treated with intravitreal dexamethasone implant injection...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785998/acute-full-thickness-macular-hole-after-uneventful-femtosecond-assisted-cataract-surgery-and-its-spontaneous-closure
#15
Deepak Bhojwani, Shail Vasavada, Aditya Sudhalkar, Viraj Vasavada, Abhay R Vasavada
No abstract text is available yet for this article.
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785994/the-efficacy-of-intravitreal-dexamethasone-implant-as-the-first-line-treatment-for-retinal-vein-occlusion-related-macular-edema-in-a-real-life-scenario
#16
Mert Simsek, Mehmet Citirik, Serdar Ozates, Dilara Ozkoyuncu
Purpose: This study evaluated the effect of intravitreal dexamethasone implant (IDI; Ozurdex) injection for treating macular edema in patients with branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). Methods: This prospective study included 40 eyes of 40 patients with nonischemic BRVO and 31 eyes of 31 patients with nonischemic CRVO who received IDI injection as the first-line treatment for macular edema. The best-corrected visual acuity (BCVA) value before and after the treatment; intraocular pressure; optic coherence tomography findings; and all ocular examination findings, including central foveal thickness (CFT) measurement and fluorescein angiography findings, were evaluated for each patient...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785993/factors-predicting-response-of-pseudophakic-cystoid-macular-edema-to-topical-steroids-and-nepafenac
#17
Sabyasachi Sengupta, Dhaivat Vasavada, Utsab Pan, Manavi Sindal
Purpose: The purpose of this study is to determine factors predicting resolution of acute pseudophakic cystoid macular edema (PCME) after 6 weeks of topical prednisolone and nepafenac application. Methods: Case records of patients with a clinical and optical coherence tomography (OCT)-based diagnosis of acute PCME were retrospectively reviewed for best-corrected visual acuity and OCT-based parameters at the time of presentation with PCME. In addition, demographic variables, intraoperative and early postoperative factors, and type of treatment prescribed (tapering vs...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785511/lamellar-macular-holes-surgical-outcome-of-106-patients-with-long-term-follow-up
#18
Marco Coassin, Valentina Mastrofilippo, Jay M Stewart, Andrea Fanti, Matteo Belpoliti, Luca Cimino, Alfonso Iovieno, Luigi Fontana
PURPOSE: To determine long-term results of vitrectomy for lamellar macular holes (LMH). To evaluate how the type of lamellar macular hole (tractional vs. degenerative) and the crystalline lens status might influence visual outcomes. METHODS: We collected data from 106 patients with symptomatic lamellar macular hole that underwent pars plana vitrectomy with membranectomy and internal limiting membrane peeling. Best-corrected visual acuity (BCVA) and optical coherence tomography appearance were determined preoperatively and postoperatively...
May 21, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29785301/impact-of-baseline-central-retinal-thickness-on-outcomes-in-the-vivid-dme-and-vista-dme-studies
#19
Edoardo Midena, Mark Gillies, Todd A Katz, Carola Metzig, Chengxing Lu, Yuichiro Ogura
Purpose: To report the impact of baseline central retinal thickness (CRT) on outcomes in patients with diabetic macular edema (DME) in VIVID-DME and VISTA-DME. Methods: Post hoc analyses of two randomized controlled trials in which 862 DME patients were randomized 1 : 1 : 1 to treatment with intravitreal aflibercept 2.0 mg every 4 weeks (2q4), intravitreal aflibercept 2.0 mg every 8 weeks after five initial monthly doses (2q8), or macular laser photocoagulation at baseline and as needed...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29784088/preventing-the-growth-of-geographic-atrophy-an-important-therapeutic-target-in-age-related-macular-degeneration
#20
EDITORIAL
Philip J Rosenfeld
No abstract text is available yet for this article.
June 2018: Ophthalmology
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