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https://www.readbyqxmd.com/read/27933400/-orbital-cavity-tumor-with-macular-folds
#1
M Kitsche, N Terai
A 40-year-old patient presented with an orbital tumor of the right eye accompanied by visual impairment and macular folds. The diagnosis of mucocele was made through clinical and radiological investigations. The excision of the mucocele was performed immediately. As early as 8 weeks after the operation, an obvious increase in visual acuity was noticed. At this time, the macular folds were no longer detectable.
December 8, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27932860/rebound-macular-edema-following-oral-acetazolamide-therapy-for-juvenile-x-linked-retinoschisis-in-an-italian-family
#2
Maria Silvana Galantuomo, Maurizio Fossarello, Alberto Cuccu, Roberta Farci, Markus N Preising, Birgit Lorenz, Pietro Emanuele Napoli
BACKGROUND: Juvenile X-linked retinoschisis (RS1, OMIM: 312700) is a hereditary vitreoretinal dystrophy characterized by bilateral foveal schisis and, in half of the patients, splitting through the nerve fiber layer in the peripheral retina. In the first decade of life, patients usually develop a decrease in visual acuity. Long-term visual outcomes can be poor due to the limited number of known successful treatments. PURPOSE: The purposes of this study were to present, for the first time, a p...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27932477/moss-produced-glycosylation-optimized-human-factor-h-for-therapeutic-application-in-complement-disorders
#3
Stefan Michelfelder, Juliana Parsons, Lennard L Bohlender, Sebastian N W Hoernstein, Holger Niederkrüger, Andreas Busch, Nicola Krieghoff, Jonas Koch, Benjamin Fode, Andreas Schaaf, Thomas Frischmuth, Martin Pohl, Peter F Zipfel, Ralf Reski, Eva L Decker, Karsten Häffner
Genetic defects in complement regulatory proteins can lead to severe renal diseases, including atypical hemolytic uremic syndrome and C3 glomerulopathies, and age-related macular degeneration. The majority of the mutations found in patients with these diseases affect the glycoprotein complement factor H, the main regulator of the alternative pathway of complement activation. Therapeutic options are limited, and novel treatments, specifically those targeting alternative pathway activation, are highly desirable...
December 8, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27930786/en-face-optical-coherence-tomography-of-cystoid-macular-edema
#4
Rohan Chawla, Koushik Tripathy
No abstract text is available yet for this article.
December 8, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27930756/a-revised-approach-for-the-detection-of-sight-threatening-diabetic-macular-edema
#5
Taras V Litvin, George H Bresnick, Jorge A Cuadros, Steve Selvin, Kuniyoshi Kanai, Glen Y Ozawa
Importance: Diabetic macular edema is one of the leading causes of vision loss among working-age adults in the United States. Telemedicine screening programs and epidemiological studies rely on monoscopic fundus photography for the detection of clinically significant macular edema (CSME). Improving the accuracy of detecting CSME from monoscopic images could be valuable while recognizing the limitations of such detection in an era of optical coherence tomography detection of diabetic macular edema...
December 8, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27930460/ocular-manifestations-and-treatment-outcomes-in-chinese-patients-with-poems-syndrome
#6
Xiao Zhang, Qian-Qian Cai, Xu-Fei Huang, Xin-Xin Cao, Hao Cai, Dao-Bin Zhou, Rong-Ping Dai, Jian Li
PURPOSE: To evaluate the relationship of serum vascular endothelial growth factor (VEGF) levels and ocular manifestations in Chinese patients with POEMS syndrome. METHODS: This is a prospective study. Forty-one treatment-naive patients were enrolled from April 2014 to November 2014. Among the 41 patients, 40 had complete ocular examination, spectral domain optical coherence tomography scan, and serum VEGF measurement before treatment and every 3-month interval after lenalidomide and dexamethasone treatment...
December 7, 2016: Retina
https://www.readbyqxmd.com/read/27930459/visual-function-correlates-of-foveal-slope-changes-on-optical-coherence-tomography-in-macular-telangiectasia-type-2
#7
Durgasri Jaisankar, Rajiv Raman, Harshal Gondhale, Jay Chhablani, Manisha Agarwal
PURPOSE: To evaluate changes in foveal and parafoveal thickness measured using optical coherence tomography across five stages of macular telangiectasia 2 (MacTel 2) and to correlate the foveal slope angle with best-corrected visual acuity (BCVA). METHODS: A multicentered, cross-sectional study of 90 patients with bilateral MacTel 2 was carried out. We reviewed medical records of patients who had undergone optical coherence tomography. Mean retinal thickness foveal and subfoveal were noted from ETDRS (Early Treatment Diabetic Retinopathy Study) mapping and later used for calculating foveal slope angle...
December 7, 2016: Retina
https://www.readbyqxmd.com/read/27930458/reproducibility-of-vessel-density-measurement-with-optical-coherence-tomography-angiography-in-eyes-with-and-without-retinopathy
#8
Qisheng You, William R Freeman, Robert N Weinreb, Linda Zangwill, Patricia I C Manalastas, Luke J Saunders, Eric Nudleman
PURPOSE: To determine the intravisit and intervisit reproducibility of optical coherence tomography angiography measurements of macular vessel density in eyes with and without retinal diseases. METHODS: Fifteen healthy volunteers and 22 patients with retinal diseases underwent repeated optical coherence tomography angiography (Angiovue Imaging System, Optovue Inc) scans after pupil dilation on 2 separate visit days. For each visit day, the eyes were scanned twice...
December 7, 2016: Retina
https://www.readbyqxmd.com/read/27930436/self-peeling-epiretinal-membrane
#9
Cem Ozgonul, Cagri G Besirli
PURPOSE: To present a self-peeling epiretinal membrane (ERM) in a patient with spontaneously improved retinal capillary hemangioma in the left eye. METHODS: We demonstrate the improvement of an untreated retinal capillary hemangioma and resolution of ERM with fundus photography, fluorescein angiography, and spectral domain optical coherence tomography. Genetic testing excluded von Hippel-Lindau disease in this patient. RESULTS: Evaluation of a patient with rheumatoid arthritis revealed retinal capillary hemangioma with retinal exudates at the temporal peripheral fundus and an ERM in the left eye...
December 7, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27929753/generation-and-characterization-of-abbv642-a-dual-variable-domain-immunoglobulin-molecule-dvd-ig-that-potently-neutralizes-vegf-and-pdgf-bb-and-is-designed-for-the-treatment-of-exudative-age-related-macular-degeneration
#10
Kun Ding, Lucia Eaton, Diana Bowley, Matthew Rieser, Qing Chang, Maria C Harris, Anca Clabbers, Feng Dong, Jikui Shen, Sean F Hackett, Debra S Touw, Jacqueline Bixby, Suju Zhong, Lorenzo Benatuil, Sahana Bose, Christine Grinnell, Gregory M Preston, Ramesh Iyer, Ramkrishna Sadhukhan, Susan Marchie, Gary Overmeyer, Tariq Ghayur, Deborah A van Riet, Shibo Tang, Peter A Campochario, Jijie Gu
Exudative age-related macular degeneration (AMD) is the most common cause of moderate and severe vision loss in developed countries. Intraocular injections of vascular endothelial growth factor (VEGF or VEGF-A)-neutralizing proteins provide substantial benefit, but frequent, long-term injections are needed. In addition, many patients experience initial visual gains that are ultimately lost due to subretinal fibrosis. Preclinical studies and early phase clinical trials suggest that combined suppression of VEGF and platelet-derived growth factor-BB (PDGF-BB) provides better outcomes than suppression of VEGF alone, due to more frequent regression of neovascularization (NV) and suppression of subretinal fibrosis...
December 8, 2016: MAbs
https://www.readbyqxmd.com/read/27929714/unusual-surprises-in-glaucoma-filtering-surgeries-lessons-learned-and-review-of-literature
#11
Aparna Rao, Debananda Padhy, Avik Kumar Roy, Sirisha Senthil
PURPOSE: To describe an unusual series of complications after glaucoma filtering surgeries with their clinical findings and outcome after tailored non-conventional modes of therapy. PATIENTS AND METHODS: Eighteen patients who underwent re-interventions (medical or surgical) after glaucoma filtering surgeries during the period at two tertiary centers, excluding those that required conventional modes of treatment (medical control or re-trabeculectomy, simple wound closure for traumatic wound dehiscence, bleb revision or needling, laser iridotomy), were included...
December 8, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27928964/hot-topics-in-pharmacogenetics-of-age-related-macular-degeneration
#12
Stephen G Schwartz, Milam A Brantley, Jaclyn L Kovach, Andrzej Grzybowski
Age-related macular degeneration (AMD) is a leading cause of irreversible visual loss and is primarily treated with nutritional supplementation as well as with anti-vascular endothelial growth factor (VEGF) agents for certain patients with neovascular disease. AMD is a complex disease with both genetic and environmental risk factors. In addition, treatment outcomes from nutritional supplementation and anti-VEGF agents vary considerably. Therefore, it is reasonable to suspect that there may be pharmacogenetic influences on these treatments...
December 8, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27928888/self-care-tools-to-treat-depressive-symptoms-in-patients-with-age-related-eye-disease-a-randomized-controlled-clinical-trial
#13
Hortence Kamga, Jane McCusker, Mark Yaffe, Maida Sewitch, Tamara Sussman, Erin Strumpf, Sébastien Olivier, Walter Wittich, Solmaz Moghadaszadeh, Ellen E Freeman
BACKGROUND: Depression is very common in people with age-related eye disease. Our goal was to determine if self-care tools plus limited telephone support could reduce depressive symptoms in patients with age-related macular degeneration (AMD) or diabetic retinopathy (DR). DESIGN: A single-blind randomized controlled clinical trial was conducted at Maisonneuve-Rosemont Hospital in Montreal, Canada. PARTICIPANTS: Eighty participants were recruited METHODS: To be eligible, participants must have had either late stage AMD or DR, at least mild depressive symptoms, and visual acuity better than 20/200...
December 7, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928876/increased-levels-of-alphab-crystallin-in-vitreous-fluid-of-patients-with-proliferative-diabetic-retinopathy-and-correlation-with-vascular-endothelial-growth-factor
#14
Wei Chen, Qianyi Lu, Li Lu, Huaijin Guan
BACKGROUND: AlphaB-crystallin has been shown to have angiogenic properties. The purpose of this study was to determine the levels of alphaB-crystallin in the vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and to confirm the association between the expression level of alphaB-crystallin and vascular endothelial growth factor (VEGF). METHODS: Vitreous samples were collected before vitrectomy from 46 eyes of 46 consecutive patients with PDR and 19 patients without diabetes mellitus (DM) had vitrectomy for idiopathic macular hole (IMH)...
December 7, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928444/the-remote-effects-of-intravitreal-anti-vegf-therapy
#15
Balta F, Merticariu M, Taban C, Neculau G, Merticariu A, Muresanu D, Badescu D, Jinga V
Objective: To study the effects of intravitreal anti-Vascular Endothelial Growth Factor (VEGF) therapy with Avastin for wet Age-Related Macular Degeneration (AMD) on Benign Prostatic Hyperplasia (BPH)-related symptoms. Methods: An exploratory trial was conducted from August 1, 2013 to February 1, 2014, that included 14 male patients previously diagnosed with BPH, who were aged between 59 and 69 years. The trial was performed in Bucharest and involved two medical institutions: the Clinical Hospital of Eye Emergencies and the "Prof...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27928377/macular-thickness-in-subjective-memory-complaints-and-mild-cognitive-impairment-a-non-invasive-biomarker
#16
Domingo Giménez Castejón, Miriama Dudekova, Maria Gómez Gallego, Jerónimo Lajara Blesa
Alzheimer's disease (AD) is the main cause of dementia worldwide, which implies an important socioeconomic problem in developed countries. Efforts to find biomarkers to diagnose AD have been intensified, especially, to detect cognitive impairment in its early stages, also known as mild cognitive impairment (MCI). Besides, there are individuals referring memory loss that is unnoticeable in the family environment and presenting normal neuropsychological tests. The former patients are included in a clinical picture that has been recently called subjective memory complaints (SMC)...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27928376/macular-ganglion-cell-layer-and-peripapillary-retinal-nerve-fibre-layer-thickness-in-patients-with-unilateral-posterior-cerebral-artery-ischaemic-lesion-an-optical-coherence-tomography-study
#17
Rita Anjos, Luisa Vieira, Livio Costa, André Vicente, Arnaldo Santos, Nuno Alves, Duarte Amado, Joana Ferreira, João Paulo Cunha
The purpose of this study is to evaluate the macular ganglion cell layer (GCL) and peripapillary retinal nerve fibre layer (RNFL) thickness in patients with unilateral posterior cerebral artery (PCA) ischaemic lesions using spectral-domain optical coherence tomography (SD-OCT). A prospective, case-control study of patients with unilateral PCA lesion was conducted in the neuro-ophthalmology clinic of Centro Hospitalar Lisboa Central. Macular and peripapillary SD-OCT scans were performed in both eyes of each patient...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27927677/comparison-of-diabetic-retinopathy-classification-using-fluorescein-angiography-and-optical-coherence-tomography-angiography
#18
Mário Soares, Catarina Neves, Inês Pereira Marques, Isabel Pires, Christian Schwartz, Miguel Ângelo Costa, Torcato Santos, Mary Durbin, José Cunha-Vaz
PURPOSE: To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. METHODS: This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab...
December 7, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27926909/dexamethasone-implant-in-chronic-diabetic-macular-edema-resistant-to-intravitreal-ranibizumab-treatment
#19
Ozlem Eski Yucel, Ertugrul Can, Hilal Eser Ozturk, Hakki Birinci, Yuksel Sullu
PURPOSE: The aim of this study was to assess the efficacy of a single intravitreal dexamethasone implant (IDI) over 6 months in eyes with chronic diabetic macular edema (DME) that were resistant to intravitreal ranibizumab (IR) treatment. METHODS: This retrospective study was conducted at the Ondokuz Mayis University Hospital, Samsun, Turkey. Efficacy outcomes were considered as the change from baseline in best corrected visual acuity (BCVA) and central macular thickness (CMT)...
December 8, 2016: Ophthalmic Research
https://www.readbyqxmd.com/read/27926906/long-term-real-life-efficacy-and-safety-of-repeated-ozurdex%C3%A2-injections-and-factors-associated-with-macular-edema-resolution-after-retinal-vein-occlusion-the-remido-2-study
#20
Stéphan Pommier, Franck Meyer, Sébastien Guigou, Tony Barthelemy, Fréderic Gobert, Christian Hajjar, Pierre-Yves Merite, Eric Parrat, Hervé Rouhette, Fréderic Matonti
PURPOSE: The objective was to study long-term real-life efficacy and safety of repeated Ozurdex® injections and factors associated with macular edema (ME) resolution after retinal vein occlusion. METHODS: Patients with ME after retinal vein occlusion, receiving Ozurdex®, were included to assess the following endpoints: visual acuity and central retinal thickness, retreatment, number of injections, side effects and ME resolution. ME resolution was defined as permanent discontinuation of intravitreal injections (IVTs) for at least 6 months after the last IVT...
December 8, 2016: Ophthalmologica. Journal International D'ophtalmologie
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