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Sign Upare CT receptors expressed in malignant colon cancer?
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G Mazzolini, I Narvaiza, L A Martinez-Cruz, A Arina, M Barajas, J C Galofré, C Qian, J M Mato, J Prieto, I Melero
Combined injections into experimental tumor nodules of adenovirus encoding IL-12 and certain chemokines are capable to induce immune-mediated complete regressions. In this study, we found that the combination of two adenoviruses, one encoding IL-12 and other MIP3alpha (AdCMVIL-12+AdCMVMIP3alpha) was very successful in treating CT-26-derived colon carcinomas. However, in experimental tumors generated from the pancreatic carcinoma cell line Panc02 such combined treatment induces 50% of macroscopic complete regressions, although local relapses within 1 week are almost constant...
July 2003: Gene Therapy
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