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https://www.readbyqxmd.com/read/28631837/transcriptional-and-histological-alterations-in-gonad-of-adult-zebrafish-after-exposure-to-the-synthetic-progestin-norgestrel
#1
Wen-Jun Shi, Jian-Liang Zhao, Yu-Xia Jiang, Guo-Yong Huang, You-Sheng Liu, Jin-Na Zhang, Guang-Guo Ying
The aim of this study was to investigate the effects of Norgestrel (NGT) on the gonadal development in adult zebrafish. Adult zebrafish were exposed to NGT for 14 days at 871 ng L(-1) for microarray analysis, and a follow-up experiment was conducted to further study targeted pathway in adult zebrafish after exposure to NGT at 6.7 ng L(-1) , 83 ng L(-1) and 912 ng L(-1) by quantitative PCR (qPCR) and histology analysis. The microarray analysis revealed that 11545 transcripts were identified. Gene ontology analysis showed organ development, system development, multicellular organismal development, single-organism developmental process and developmental process were significantly enriched...
June 20, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28626058/risk-of-stroke-with-various-types-of-menopausal-hormone-therapies-a-national-cohort-study
#2
Ellen Løkkegaard, Lars Hougaard Nielsen, Niels Keiding
BACKGROUND AND PURPOSE: Double-blind randomized studies on the effects of oral postmenopausal hormone therapies were stopped mainly because of increased risk of stroke. We aimed to assess the risk of all strokes and various subtypes associated with hormone therapy and explore the influence of regimens and routes of administration. METHODS: A national historical cohort of women aged 51 to 70 years from 1995 to 2010 was established by linking 5 Danish registries. The National Registry of Medicinal Product Statistics provided information on hormone therapy exposure and the National Patient or Cause of Death Registries supplied data regarding stroke diagnoses (ischemic/hemorrhagic/subarachnoid hemorrhage)...
June 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28601762/warming-modulates-the-effects-of-the-endocrine-disruptor-progestin-levonorgestrel-on-the-zebrafish-fitness-ovary-maturation-kinetics-and-reproduction-success
#3
P G Cardoso, D Rodrigues, T V Madureira, N Oliveira, M J Rocha, E Rocha
Interactive effects between multiple stressors, namely climate drivers (e.g., temperature) and chemical pollution (e.g., endocrine disruptors) are poorly studied. Here, it was for the first time evaluated the combinatory effects of temperature and a synthetic progestin, levonorgestrel (LNG), on the fitness and reproductive-related endpoints of zebrafish (Danio rerio). A multi-factorial design was implemented by manipulating both temperature [setting as baseline an ambient temperature of 27 °C, against warming (+3 °C)] and LNG levels (10 ngL(-1) and 1000 ngL(-1))...
June 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28601159/abnormal-pregnancies-associated-with-deviation-in-progestin-and-estrogen-profiles-in-late-pregnant-mares-a-diagnostic-aid
#4
Mitsumori Shikichi, Katsuroku Iwata, Katsumi Ito, Daisuke Miyakoshi, Harutaka Murase, Fumio Sato, Kenji Korosue, Shunichi Nagata, Yasuo Nambo
Measurement of progestines and estrogens in maternal plasma has been advocated as an indicator of foeto-placental function. The goals of the present study were as follows: to determine progestin and estrogen concentrations in mares with normal and abnormal pregnancies during late gestation, evaluate the diagnostic value of hormone concentrations, and investigate the relationship between hormone concentrations after treatment and the survival of foals. Blood samples were collected monthly from 459 pregnant mares between Day 201 of gestation and foaling...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28597496/elevated-anti-mullerian-hormone-in-lean-women-may-not-indicate-polycystic-ovarian-syndrome
#5
Rachel A Bradbury, Paul Lee, Howard C Smith
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a heterogeneous disorder with clinical features shared with functional hypogonadotrophic hypogonadism (FHH). AIM: To investigate the usefulness of an elevated (>40 pmol/L) anti-Mullerian hormone (AMH) in identifying PCOS and distinguishing PCOS from FHH. MATERIALS AND METHODS: 141 patients with an elevated AMH and body mass index either <20 kg/m(2) (lean) or >30 kg/m(2) (obese) were selected and three subgroups analysed - obese, lean, lean with suspected FHH...
June 9, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28588047/availability-and-quality-of-family-planning-services-in-the-democratic-republic-of-the-congo-high-potential-for-improvement
#6
Dieudonné Mpunga, J P Lumbayi, Nelly Dikamba, Albert Mwembo, Mala Ali Mapatano, Gilbert Wembodinga
OBJECTIVE: To determine the availability and quality of family planning services within health facilities throughout the Democratic Republic of the Congo (DRC). METHODS: Data were collected for the cross-sectional study from April 2014 to June 2014 by the Ministry of Public Health. A total of 1,568 health facilities that reported data to the National Health Information System were selected by multistage random sampling in the 11 provinces of the DRC existing at that time...
June 6, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28585217/obesity-associated-breast-cancer-analysis-of-risk-factors
#7
Atilla Engin
Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are at higher risk of all-cause and breast cancer specific mortality when compared to non-obese women with breast cancer. In this context, increased levels of estrogens due to excessive aromatization activity of the adipose tissue, overexpression of pro-inflammatory cytokines, insulin resistance, hyperactivation of insulin-like growth factors (IGFs) pathways, adipocyte-derived adipokines, hypercholesterolemia and excessive oxidative stress contribute to the development of breast cancer in obese women...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28579829/natural-and-synthetic-progestins-enrich-cancer-stem-cell-like-cells-in-hormone-responsive-human-breast-cancer-cell-populations-in-vitro
#8
Sandy Goyette, Yayun Liang, Benford Mafuvadze, Matthew T Cook, Moiz Munir, Salman M Hyder
Clinical trials and studies have shown that combination estrogen/progestin hormone replacement therapy, but not estrogen therapy alone or placebo, increases breast cancer risk in postmenopausal women. Using animal models, we have previously shown that both natural and synthetic progestins (including medroxyprogesterone acetate [MPA], a synthetic progestin used widely in the clinical setting) accelerate the development of breast tumors in vivo and increase their metastasis to lymph nodes. Based on these observations, we have hypothesized that progestin-induced breast cancer tumor growth and metastasis may be mediated by an enrichment of the cancer stem cell (CSC) pool...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28579813/evaluation-of-the-treatment-patterns-and-economic-burden-of-dysmenorrhea-in-japanese-women-using-a-claims-database
#9
Sayako Akiyama, Erika Tanaka, Olivier Cristeau, Yoshie Onishi, Yutaka Osuga
PURPOSE: This study aimed to describe treatment patterns and estimate health care resource utilization and associated costs among Japanese women with dysmenorrhea, using a claims database. METHODS: This was a retrospective analysis using health insurance data from the Japan Medical Data Center, assessing female patients aged 18-49 years with newly diagnosed primary or secondary dysmenorrhea. Treatment pattern analyses focused on hormonal medications, analgesics, hemostatic agents, traditional Chinese medicine (TCM), and gynecological surgeries...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28570827/race-menopausal-hormone-therapy-and-invasive-breast-cancer-in-the-carolina-breast-cancer-study
#10
Nathan L DeBono, Whitney R Robinson, Jennifer L Lund, Chiu Kit Tse, Patricia G Moorman, Andrew F Olshan, Melissa A Troester
PURPOSE: The use of combined estrogen-progestin menopausal hormone therapy (MHT) has been shown to increase the risk of breast cancer, however, recent observational studies have suggested that the association between MHT and breast cancer may be modified by race. The objective of this study was to investigate the association between MHT use and incidence of invasive breast cancer in Black and White women aged ≥40 years at diagnosis after accounting for racial differences in patterns of MHT use and formulation...
June 1, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28567743/the-use-of-selective-progestin-receptor-modulators-sprm-and-more-specifically-ulipristal-acetate-in-the-practice-of-gynaecology
#11
REVIEW
Serge Rozenberg, Julie Praet, Eliza Pazzaglia, Christine Gilles, Yannick Manigart, Jean Vandromme
This review discusses the development of selective progestin receptor modulators (SPRM) for use in women's health and specifically the use of ulipristal acetate (UPA) as emergency contraception (EC) and as a treatment for symptomatic fibroids in women who want to preserve their fertility or avoid a hysterectomy. As an EC, UPA 30 mg should be recommended for women, within 102 h of unprotected intercourse. As a treatment of fibroids, UPA (5 mg daily dose) should be administered for periods of three months as a pre-surgical strategy, reducing bleeding and fibroid size and facilitating surgery...
June 1, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28560431/overexpression-of-mir-15b-5p-promotes-gastric-cancer-metastasis-by-regulating-paqr3
#12
Chengcheng Zhao, Yan Li, Gang Chen, Fen Wang, Zhili Shen, Rongping Zhou
Gastric cancer (GC) is the fifth most common cancer in the world, with 952,000 new cases diagnosed in 2012. Tumor metastasis is the major cause of cancer recurrence and death. miR-15b-5p has been reported to be dysregulated in numerous types of cancers. However, the role of miR-15b-5p in GC metastasis remains unclear. An miRNA microarray was adopted to analyze the miRNA expression profile. By employing quantitative real-time polymerase chain reaction (qRT-PCR), miR-15b-5p expression levels were detected in GC cell lines, tissues and plasma samples...
May 26, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28554244/effectiveness-of-the-progestin-only-pill-for-migraine-treatment-in-women-a-systematic-review-and-meta-analysis
#13
Samantha Warhurst, Christopher J Rofe, Bruce J Brew, Deborah Bateson, Kevin McGeechan, Gabriele S Merki-Feld, Raymond Garrick, Susan E Tomlinson
Background Migraine is highly prevalent in women (18%). Peak morbidity affects their most productive years, coinciding with peak fertility. Hormonal contraception is often tailored for migraine prevention. Estrogen-containing contraceptives may be contraindicated in women experiencing migraine with aura due to the risk of vascular events. While improvements in migraine with a progestin-only pill (POP), which inhibits ovulation are documented, the strength and quality of evidence has not been formally evaluated...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28548040/paqr3-inhibits-the-proliferation-and-tumorigenesis-in-esophageal-cancer-cells
#14
Fang Zhou, Shunchang Wang, Jianjun Wang
Progestin and adipoQ receptor family member III (PAQR3), a member of the PAQR family, is frequently downregulated in different types of human cancer. However, its expression and functions in esophageal cancer are still unknown. This study aimed to explore the expression of PAQR3 in esophageal cancer cell lines and to investigate the role of PAQR3 in the development of esophageal cancer. Our data showed that PAQR3 is expressed in low amounts in human esophageal cancer cell lines. Overexpression of PAQR3 significantly suppressed the proliferation, migration, and invasion of esophageal cancer cells...
May 24, 2017: Oncology Research
https://www.readbyqxmd.com/read/28544938/sex-steroids-and-metabolic-responses-in-mussels-mytilus-galloprovincialis-exposed-to-drospirenone
#15
Tiziana Cappello, Denise Fernandes, Maria Maisano, Andrea Casano, Marta Bonastre, Maria João Bebianno, Angela Mauceri, Salvatore Fasulo, Cinta Porte
Drospirenone (DRO) is a synthetic progestin derived from 17α-spironolactone with a pharmacological mechanism of action similar to progesterone. Despite its wide use as pharmaceutical and consequent continuous release into the aquatic environment, DRO effects have been poorly investigated on aquatic biota. In order to unravel the toxicity mechanisms of DRO, mussels Mytilus galloprovincialis were exposed for 7 days to different concentrations of DRO, namely 20ng/L (Low; L), 200ng/L (Medium; M), 2000ng/L (High; H) and 10μg/L (Super High; SH) nominal doses...
May 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28530033/concomitant-contraceptive-implant-and-efavirenz-use-in-women-living-with-hiv-perspectives-on-current-evidence-and-policy-implications-for-family-planning-and-hiv-treatment-guidelines
#16
REVIEW
Rena C Patel, Chelsea Morroni, Kimberly K Scarsi, Tabitha Sripipatana, James Kiarie, Craig R Cohen
INTRODUCTION: Preventing unintended pregnancies is important among all women, including those living with HIV. Increasing numbers of women, including HIV-positive women, choose progestin-containing subdermal implants, which are one of the most effective forms of contraception. However, drug-drug interactions between contraceptive hormones and efavirenz-based antiretroviral therapy (ART) may reduce implant effectiveness. We present four inter-related perspectives on this issue. DISCUSSION: First, as a case study, we discuss how limited data prompted country-level guidance against the use of implants among women concomitantly using efavirenz in South Africa and its subsequent negative effects on the use of implants in general...
May 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28528182/paqr3-inhibits-the-proliferation-migration-and-invasion-in-human-glioma-cells
#17
Shi-Lei Tang, Yuan-Lin Gao, Wen-Zhong Hu
Progestin and AdipoQ Receptor 3 (PAQR3), a member of the PAQR family, is down-regulated in several types of cancers and has been closely associated with tumor progression and development. However, little is known about the functions of PAQR3 in the tumorigenesis of human glioma. Therefore, in this report, we investigated the role of PAQR3 in human glioma. Our results showed that the expression of PAQR3 was significantly reduced in human glioma tissues and cell lines. PAQR3 overexpression inhibited the proliferation of glioma cells in vitro and attenuated tumor xenograft growth in vivo...
May 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28526167/significance-of-body-weight-change-during-fertility-sparing-progestin-therapy-in-young-women-with-early-endometrial-cancer
#18
Jeong-Yeol Park, Seok Ju Seong, Tae-Jin Kim, Jae Weon Kim, Duk-Soo Bae, Joo-Hyun Nam
OBJECTIVE: To evaluate the influence of body weight change during fertility-sparing progestin therapy on oncologic and reproductive outcomes in young women with early-stage endometrial cancer who did not complete child bearing. METHODS: This multicenter, retrospective study included 154 young patients with well-differentiated, endometrium-confined endometrioid endometrial adenocarcinoma on magnetic resonance imaging who received fertility-sparing progestin therapy...
May 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28524239/oral-contraceptive-pills-risky-or-protective-in-case-of-trichinella-spiralis-infection
#19
Marwa A Hasby Saad, Dina A Radi, Eiman A Hasby
AIM: to investigate how Trichinella spiralis infection can be affected by contraceptive pills invivo. METHODS: included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs), infected receiving COCPs and infected receiving POPs. Parasite burden was measured (two gender worm counts, gravidity, larvae/muscle and RCI). Histopathological examination, immunohistochemical detection of C-kit mast cells & Foxp3+ T-reg...
May 19, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28522756/influence-of-sex-menstrual-cycle-and-oral-contraceptives-on-cerebrovascular-resistance-and-cardiorespiratory-function-during-valsalva-or-standing
#20
Syed Abidi, Misha Nili, Stephania Serna, Simon Kim, Christopher Hazlett, Heather Edgell
Women experience orthostatic intolerance more than men, and experience faintness more in the early follicular (i.e. low hormone (LH)) compared to the luteal (i.e. high hormone (HH)) phase of the menstrual cycle. Men (n=13, age: 25.8±1.8) and women in the LH (day 2-5; placebo) and HH) (day 18-24; high dose) phases of the menstrual cycle with (OC; n=14, age: 22.0±0.8) or without oral contraceptives (NOC; n=12, age: 21.8±0.5) underwent the Valsalva maneuver and a supine-sit-stand protocol. Blood pressure, normalized stroke volume (SVi), cardiac output index (Qi), heart rate (HR), end-tidal carbon dioxide (ET-CO2), and middle cerebral artery blood velocity (MCA) were measured...
May 18, 2017: Journal of Applied Physiology
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