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Alprostadil

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https://www.readbyqxmd.com/read/28280146/association-between-treatment-for-erectile-dysfunction-and-death-or-cardiovascular-outcomes-after-myocardial-infarction
#1
Daniel P Andersson, Ylva Trolle Lagerros, Alessandra Grotta, Rino Bellocco, Mikael Lehtihet, Martin J Holzmann
OBJECTIVE: Erectile dysfunction (ED) is associated with an increased risk of cardiovascular disease in healthy men. However, the association between treatment for ED and death or cardiovascular outcomes after a first myocardial infarction (MI) is unknown. METHODS: In a Swedish nationwide cohort study all men <80 years of age without prior MI, or cardiac revascularisation, hospitalised for MI during 2007-2013 were included. Treatment for ED, defined as dispensed phosphodiesterase-5 inhibitors or alprostadil, was related to risk of death, MI, cardiac revascularisation or heart failure...
March 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28255370/erectile-dysfunction-post-radical-prostatectomy-a-challenge-for-both-patient-and-physician
#2
REVIEW
O Bratu, I Oprea, D Marcu, D Spinu, A Niculae, B Geavlete, D Mischianu
Post-radical prostatectomy erectile dysfunction (post RP ED) is a major postoperative complication with a great impact on the quality of life of the patients. Until present, no proper algorithm or guideline based on the clinical trials has been established for the management of post RP ED. According to literature, it is better to initiate a penile rehabilitation program as soon as possible after surgery than doing nothing, in order to prevent and limit the postoperative local hypoxygenation and fibrosis. The results of numerous clinical trials regarding the effectiveness of the phosphodiesterase 5 inhibitors therapy on post RP ED have made them the gold standard treatment...
January 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28228888/bilateral-external-and-internal-pudendal-veins-embolization-treatment-for-venogenic-erectile-dysfunction
#3
Daniel Lee, Eran Rotem, Ronald Lewis, Satyam Veean, Ashwin Rao, Alison Ulbrandt
Erectile dysfunction (ED) or impotence is estimated to affect around 20-30 million men in the United States (Rhoden et al, 2002). Vascular etiology is purported to be the most prevalent cause of ED in the elderly population, with venogenic ED being the most common subtype (Shafik et al, 2007; Rebonato et al, 2014). A patient, who developed severe venogenic ED, was referred to interventional radiology after ineffective pharmaceutical treatments. Selective embolization of bilateral external and internal pudendal veins was performed through accessing the deep dorsal vein of penis...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28125566/association-between-il-18-and-carotid-intima-media-thickness-in-patients-with-type-ii-diabetic-nephropathy
#4
Yuanyuan Zhang, Haomiao Feng, Zhiyong Wei
BACKGROUND We specifically designed this study to determine the relationship between levels of IL-8 and carotid intima-media thickness (cIMT) in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS A total of 149 diabetic patients at different stages of diabetic nephropathy and 72 matched controls were recruited in this study. A wide range of parameters were measured: IL-18 (by ELISA), urinary albumin excretion rates (UAER), and carotid intima-media thickness (cIMT, by pulse wave velocity [PWV])...
January 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28031668/bilateral-superficial-femoral-artery-thrombosis-in-a-15-year-old-caucasian-male-with-homozygous-prothrombin-g20210a-genotype-and-associated-antiphospholipid-syndrome
#5
Uzung Yoon, LaiLai Kwok, Ingo Flessenkaemper
Prothrombin mutation was usually associated with other well-established predisposing factors for venous thrombosis such as antiphospholipid antibodies. Recently, even isolated prothrombin gene mutation G20210A has been reported to present severe or unusual vein thrombosis. Less clear is the role of prothrombin mutation in the formation of arterial thrombosis. We present a case of a 15-year-old healthy White male with acute bilateral femoral artery thrombosis. The patient presented with increasing left leg pain for about 1 week...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27930430/w1-a-novel-oral-antiplatelet-agent-with-less-resistance-than-clopidogrel
#6
Pengxin Ge, Li Du, Chunguang Han, Hui Li, Yanguo Feng, Jie Han, Zhen Wang, Liangzhong Xiong, Meiru Yuan, Yongxue Liu
Clopidogrel is a clinical antiplatelet agent, about which there are major concerns because its antiplatelet efficiency decreases with insufficient metabolic activation, leading to "clopidogrel resistance." We aimed to determine the antiplatelet effects of W1, a novel molecule composed of 2-O-clopidogrel and aspirin (1:1 ratio), on platelet aggregation ex vivo and thrombus formation in vivo, and its susceptibility to "clopidogrel resistance" in combination with other therapies in rats. Platelets were prepared, and an arteriovenous shunt thrombosis model was established using Wistar rats to measure platelet aggregation and thrombus formation, respectively...
November 24, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27929275/erectile-dysfunction
#7
Karl T Rew, Joel J Heidelbaugh
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is common, affecting at least 12 million U.S. men. The five-question International Index of Erectile Function allows rapid clinical assessment of ED. The condition can be caused by vascular, neurologic, psychological, and hormonal factors. Common conditions related to ED include diabetes mellitus, hypertension, hyperlipidemia, obesity, testosterone deficiency, and prostate cancer treatment...
November 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928427/alprostadil-cream-in-the-treatment-of-erectile-dysfunction-clinical-evidence-and-experience
#8
REVIEW
Béatrice Cuzin
Erectile dysfunction (ED) is a very common disorder with a deep impact on quality of life on both patients and partners. Several options are available for treating ED: oral pharmacotherapy with phosphodiesterase 5 (PDE5) inhibitors currently represents the first-line option for many patients with ED. Alprostadil, a prostaglandin, has been marketed for many years as a urethral stick and an intracavernous injection for the treatment of ED. It is now available in the form of a cream (Vitaros/Virirec), a noninvasive treatment which combines an active drug (alprostadil, a synthetic prostaglandin E1) with a skin enhancer improving its local absorption directly at the site of action...
August 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27902617/efficacy-of-bosentan-in-patients-with-refractory-thromboangiitis-obliterans-buerger-disease-a-case-series-and-review-of-the-literature
#9
REVIEW
Javier Narváez, Carmen García-Gómez, Lorenzo Álvarez, Pilar Santo, María Aparicio, María Pascual, Mercè López de Recalde, Helena Borrell, Joan M Nolla
The cornerstone of therapy in thromboangiitis obliterans (TAO) is complete abstinence from tobacco. In addition to discontinuation of cigarette smoking, very few pharmacological and surgical options of controversial efficacy are available to date. New therapeutic options with greater efficacy are clearly needed to properly manage these patients.In this preliminary study, we assessed the effectiveness and safety of bosentan in a case series of 8 adults with TAO and severe ischemic ulceronecrotic lesions who were treated with bosentan after inadequate response to platelet inhibitors, vasodilators, and intravenous alprostadil...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27871959/intracavernous-injections-in-spinal-cord-injured-men-with-erectile-dysfunction-a-systematic-review-and-meta-analysis
#10
REVIEW
Lucie Chochina, Florian Naudet, Clément Chéhensse, Andrea Manunta, Mireille Damphousse, Isabelle Bonan, François Giuliano
INTRODUCTION: Despite improvements in the care of patients after spinal cord injury (SCI), permanent impairment of locomotion, sensation, and autonomic function remains a major hurdle. After the acute stage of injury, recovering sexual function is a high priority. AIM: To review the efficacy of intracavernous injections (ICIs) in men with SCI and to identify prognostic factors affecting the efficacy of ICIs in this population. METHODS: Systematic review of the literature was conducted using the PubMed-Medline, Embase, EBSCO, Web of Science, and Cochrane Library databases...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27865471/satisfaction-and-treatment-adherence-in-erectile-dysfunction-in-the-medium-and-long-term
#11
J Panach-Navarrete, A Morales-Giraldo, C Ferrandis-Cortés, F García-Morata, J C Pastor-Lence, J M Martínez-Jabaloyas
INTRODUCTION: The aim of this study was to show the satisfaction and treatment adherence in erectile dysfunction (ED) in the medium and long term. MATERIAL AND METHODS: A descriptive, comparative study was conducted in 2 centres through telephone interviews with patients who came for an initial visit between 2012 and 2014 for ED. A complete case history review was conducted on the use of and withdrawal from treatment. For current use, the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) and the Global Assessment Questionnaire (GAQ) were filled out; for past use, only the GAQ was filled out...
November 16, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27861357/the-effect-of-alprostadil-on-preventing-contrast-induced-nephropathy-for-percutaneous-coronary-intervention-in-diabetic-patients-a-systematic-review-and-meta-analysis
#12
REVIEW
Ziliang Ye, Haili Lu, Wenqin Guo, Weiran Dai, Hongqing Li, Huafeng Yang, Lang Li
BACKGROUND: At present, there are a lot of research about the effect of Alprostadil on preventing contrast-induced nephropathy for percutaneous coronary intervention (PCI) in diabetic patients, but the clinical efficacy is not consistent, so we conduct this study and therefore determine the dominant strategy for the treatment of PCI in diabetic patients based on the best evidence currently. METHODS: An electronic database search was conducted in MEDLINE, Embase, Cochrane library, CBM, CNKI, VIP, and WanFang to retrieve randomized controlled trial (RCT) comparing Alprostadil versus hydration on preventing CIN for PCI in diabetic patients...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27735021/study-on-the-clinical-value-of-alprostadil-combined-with-%C3%AE-lipoic-acid-in-treatment-of-type-2-diabetes-mellitus-patients-with-erectile-dysfunction
#13
L Zhang, H-Y Zhang, F-C Huang, Q Huang, C Liu, J-R Li
OBJECTIVE: We investigated the clinical value of alprostadil combined with the α-lipoic acid in treating type 2 diabetes mellitus with erectile dysfunction (DMED). PATIENTS AND METHODS: We selected a total of 76 cases of patients who were admitted to endocrinology department of our hospital from June 2014 to June 2015 and diagnosed as DMED, and the average age was (46.7 ± 7.2) years old, average course of diabetes mellitus was (6.2 ± 2.8) years and average body mass index was (25...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27707552/comparative-effectiveness-of-12-treatment-strategies-for-preventing-contrast-induced-acute-kidney-injury-a-systematic-review-and-bayesian-network-meta-analysis
#14
Xiaole Su, Xinfang Xie, Lijun Liu, Jicheng Lv, Fujian Song, Vlado Perkovic, Hong Zhang
BACKGROUND: To simultaneously evaluate the relative efficacy of multiple pharmacologic strategies for preventing contrast-induced acute kidney injury (AKI). STUDY DESIGN: Systematic review containing a Bayesian network meta-analysis of randomized controlled trials. SETTING & POPULATION: Participants undergoing diagnostic and/or interventional procedures with contrast media. SELECTION CRITERIA FOR STUDIES: Randomized controlled trials comparing the active drug treatments with each other or with hydration alone...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27690728/vacuum-erection-device-in-treatment-of-organic-erectile-dysfunction-and-penile-vascular-differences-between-patients-with-dm-type-i-and-dm-type-ii
#15
Bogdan Pajovic, Antonio Dimitrovski, Nikola Fatic, Milos Malidzan, Marko Vukovic
The aim of this study is to investigate changes in the vascular system and hemodynamics between patients with organic erectile dysfunction (ED) (DM type I and II), as well as to compare the quality of sexual life between those two groups after the treatment with vacuum erection device (VED). Study enrolled 50 males with DM, aged from 35 to 67 years, who have attended the urologic clinic due to inability to attain and maintain an erection of the penis sufficient to permit satisfactory sexual intercourse. Patients were using VED and six months later were assessed for therapy results...
October 1, 2016: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/27676717/intracavernous-injections-in-spinal-cord-injured-men-with-erectile-dysfunction-a-systematic-review-and-meta-analysis
#16
Lucie Chochina, Florian Naudet, Isabelle Bonan, Clément Chehensse, Mireille Damphousse, Andrea Manunta, François Giuliano
OBJECTIVE: To review the efficacy of intracavernous injections (ICI) in spinal cord injured (SCI) men and to identify prognostic factors affecting the efficacy of ICI in this population. MATERIAL/PATIENTS AND METHODS: Systematic review of the literature using 5 databases. Articles published up to november 2014 using the keywords: alprostadil; papaverine; moxisylyte; alpha-blocking agent; phentolamine; intracavernous injection; spinal cord injuries; paraplegia; quadriplegia; erectile dysfunction; were included...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27601882/effects-of-alprostadil-and-iloprost-on-renal-lung-and-skeletal-muscle-injury-following-hindlimb-ischemia-reperfusion-injury-in-rats
#17
Dilek Erer, Abdullah Özer, Hüseyin Demirtaş, İpek Işık Gönül, Halil Kara, Hande Arpacı, Faruk Metin Çomu, Gürsel Levent Oktar, Mustafa Arslan, Ayşegül Küçük
OBJECTIVES: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental rat model. MATERIALS AND METHODS: Wistar albino rats underwent 2 hours of ischemia via infrarenal aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the reperfusion period...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27570092/erectile-function-after-treatment-for-rhabdomyosarcoma-of-prostate-and-bladder
#18
S Frees, P Rubenwolf, C Ziesel, J Faber, P Gutjahr, A Grossmann, J W Thüroff, R Stein
INTRODUCTION: Rhabdomyosarcoma (RMS) accounts for 5% of all pediatric tumors; 15-20% of these tumors are located in the urogenital tract, mostly originating from the prostate or bladder. In the light of the steadily improving prognosis for patients with RMS through interdisciplinary-multimodal study protocols with 60-70% long-term survivors, non oncological aspects such as erectile function (EF) have become increasingly important. The aim of this study was to evaluate EF in patients having undergone treatment for RMS of the bladder and prostate...
December 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27556578/anti-inflammatory-signaling-during-ex-vivo-liver-perfusion-improves-the-preservation-of-pig-liver-grafts-before-transplantation
#19
Nicolas Goldaracena, Juan Echeverri, Vinzent N Spetzler, Johan M Kaths, Andrew S Barbas, Kristine S Louis, Oyedele A Adeyi, David R Grant, Nazia Selzner, Markus Selzner
Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemia injury. We investigated whether the protective effects of NEVLP can be further improved by applying strategies targeted on reducing the activation of proinflammatory cytokines during perfusion. Livers retrieved under heart-beating conditions were perfused for 4 hours. Following the preservation period, a pig liver transplantation was performed. In group 1 (n = 5), anti-inflammatory strategies (alprostadil, n-acetylcysteine, carbon monoxide, sevoflurane, and subnormothermic temperature [33°C]) were applied...
November 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27536559/clinical-use-of-alprostadil-topical-cream-in-patients-with-erectile-dysfunction-a-review
#20
REVIEW
James Anaissie, Wayne Jg Hellstrom
Erectile dysfunction (ED) is a common and debilitating disorder seen in over 50% of men older than 70 years. Oral phosphodiesterase type 5 (PDE5) inhibitors are the mainstay of treatment for ED, but cannot be used by a significant subset of patients due to systemic side effects and drug-drug interactions. Second-line therapy may include intracavernosal therapies, but are associated with poor compliance due to their invasive nature. Alprostadil has a mechanism of action different from that of PDE5 inhibitors...
2016: Research and Reports in Urology
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