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Propionate

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https://www.readbyqxmd.com/read/28735600/evidence-for-increasing-digestive-and-metabolic-efficiency-of-energy-utilization-with-age-of-dairy-cattle-as-determined-in-two-feeding-regimes
#1
F Grandl, J O Zeitz, M Clauss, M Furger, M Kreuzer, A Schwarm
The changes taking place with age in energy turnover of dairy cattle are largely unknown. It is unclear whether the efficiency of energy utilization in digestion (characterized by faecal and methane energy losses) and in metabolism (characterized by urine and heat energy losses) is altered with age. In the present study, energy balance data were obtained from 30 lactating Brown Swiss dairy cows aged between 2 and 10 years, and 12 heifers from 0.5 to 2 years of age. In order to evaluate a possible dependence of age effects on diet type, half of the cattle each originated from two herds kept at the same farm, which were fed either on a forage-only diet or on the same forage diet but complemented with 5 kg/day of concentrate since their first calving...
July 24, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28735588/mode-of-action-of-saccharomyces-cerevisiae-in-enteric-methane-mitigation-in-pigs
#2
Y L Gong, J B Liang, M F Jahromi, Y B Wu, A G Wright, X D Liao
The objectives of this study were to determine the effect and mode of action of Saccharomyces cerevisiae (YST2) on enteric methane (CH4) mitigation in pigs. A total of 12 Duroc×Landrace×Yorkshire male finisher pigs (60±1 kg), housed individually in open-circuit respiration chambers, were randomly assigned to two dietary groups: a basal diet (control); and a basal diet supplemented with 3 g/YST2 (1.8×1010 live cells/g) per kg diet. At the end of 32-day experiment, pigs were sacrificed and redox potential (Eh), pH, volatile fatty acid concentration, densities of methanogens and acetogens, and expression of methyl coenzyme-M reductase subunit A gene were determined in digesta contents from the cecum, colon and rectum...
July 24, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28733999/retinyl-propionate-and-climbazole-combination-demonstrates-clinical-improvement-to-the-appearance-of-hyperpigmentation-and-deep-wrinkling-with-minimal-irritation
#3
Stacy Hawkins, Jean Adamus, Chung-Yi Chiang, Edwin Covell, Jaime O'Leary, Jian-Ming Lee
OBJECTIVE: To evaluate a combination of retinyl propionate and climbazole (RPC) compared to 0.1% retinol for its efficacy, tolerance and aging appearance. METHOD: Forty-five healthy Caucasian females, ages 40-70, with moderately photodamaged facial skin, were recruited for a 16 week randomized, double-blind, IRB approved facial study. The efficacy of RPC treatment was compared to 0.1% retinol, in the same product base formulation, with twice daily, split-face product application...
July 22, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28733671/short-chain-fatty-acids-and-inulin-but-not-guar-gum-prevent-diet-induced-obesity-and-insulin-resistance-through-differential-mechanisms-in-mice
#4
Karolin Weitkunat, Christin Stuhlmann, Anna Postel, Sandra Rumberger, Maria Fankhänel, Anni Woting, Klaus Jürgen Petzke, Sabrina Gohlke, Tim J Schulz, Michael Blaut, Susanne Klaus, Sara Schumann
The role of dietary fibre and short-chain fatty acids (SCFA) in obesity development is controversially discussed. Here, we investigated how various types of dietary fibre and different SCFA ratios affect metabolic syndrome-related disorders. Male mice (B6) were fed high-fat diets supplemented with dietary fibres (either cellulose, inulin or guar gum) or different Ac:Pr ratios (high acetate (HAc) or propionate (HPr)) for 30 weeks. Body-fat gain and insulin resistance were greatly reduced by inulin, but not by guar gum, and completely prevented by SCFA supplementation...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732831/initiating-or-changing-to-a-fixed-dose-combination-of-fluticasone-propionate-formoterol-over-fluticasone-propionate-salmeterol-a-real-life-effectiveness-and-cost-impact-evaluation
#5
Simon Wan Yau Ming, John Haughney, Iain Small, Stephanie Wolfe, John Hamill, Kevin Gruffydd-Jones, Cathal Daly, Joan B Soriano, Elizabeth Gardener, Derek Skinner, Martina Stagno d'Alcontres, David B Price
OBJECTIVE: Asthma has a substantial impact on quality of life and health care resources. The identification of a more cost-effective, yet equally efficacious, treatment could positively influence the economic burden of this disease. Fluticasone propionate/Formoterol (FP/FOR) may be as effective as Fluticasone Salmeterol (FP/SAL). We evaluated non-inferiority of asthma control in terms of the proportion of patients free from exacerbations, and conducted a cost impact analysis. METHODS: This historical, matched cohort database study evaluated two treatment groups in the Optimum Patient Care Research Database in the UK: 1) an FP/FOR cohort of patients initiating treatment with FP/FOR or changing from FP/SAL to FP/FOR and; 2) an FP/SAL cohort comprising patients initiating, or remaining on FP/SAL pMDI combination therapy...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28731156/protein-interacting-with-c%C3%A2-kinase-1-modulates-exocytosis-and-katp-conductance-in-pancreatic-%C3%AE-cells
#6
Yunhong Li, Fan Li, Bin Bai, Zhenyong Wu, Xiaolin Hou, Ying Shen, Yin Wang
It has been previously identified that α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPARs) are expressed in pancreatic β cells and regulate exocytosis and insulin release. It is known that protein interacting with C‑kinase 1 (PICK1) regulates trafficking and synaptic targeting of AMPARs in the central nervous system. However, it is unknown whether PICK1 regulates glutamate‑induced insulin release in β cells. The present study demonstrated that glutamate‑induced exocytosis was increased in β cells derived from PICK1‑knockout mice...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730825/the-implication-of-ampa-receptor-in-synaptic-plasticity-impairment-and-intellectual-disability-in-fragile-x-syndrome
#7
G-R Cheng, X-Y Li, Y-D Xiang, D Liu, S M McClintock, Y Zeng
Fragile X syndrome (FXS) is the most frequently inherited form of intellectual disability and prevalent single-gene cause of autism. A priority of FXS research is to determine the molecular mechanisms underlying the cognitive and social functioning impairments in humans and the FXS mouse model. Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate a majority of fast excitatory neurotransmission in the central nervous system and are critically important for nearly all aspects of brain function, including neuronal development, synaptic plasticity, and learning and memory...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28729856/biological-significance-of-marine-actinobacteria-of-east-coast-of-andhra-pradesh-india
#8
Alapati Kavitha, Handanahal S Savithri
An attempt was made to identify actinobacterial strains present in the marine soil of East Coast regions viz., Chirala, Bapatla, and Peddaganjam, Andhra Pradesh; Kanyakumari, Tamil Nadu and Goa, Goa along with the study of their antimicrobial potential. Eight out of 73 actinobacterial strains isolated from these regions showed strong antimicrobial activity against Gram positive bacteria, Gram negative bacteria, and Candida albicans. Molecular identification (16S rRNA analysis) of the eight strains revealed that they belong to Dietzia sp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28729272/draft-genome-sequence-of-paludibacter-jiangxiensis-nm7-t-a-propionate-producing-fermentative-bacterium
#9
Yan-Ling Qiu, Dieter M Tourlousse, Norihisa Matsuura, Akiko Ohashi, Yuji Sekiguchi
We report here a high-quality draft genome sequence of Paludibacter jiangxiensis strain NM7(T), a mesophilic, anaerobic, propionate-producing fermentative bacterium within the family Porphyromonadaceae of the phylum Bacteroidetes The genome comprises 3,664,884 bp in four contigs, has a G+C content of 42.92%, and contains 2,949 protein-coding sequences and 62 RNAs.
July 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28728374/analysis-of-metabolomic-patterns-in-thoroughbreds-before-and-after-exercise
#10
Hyun-Jun Jang, Duk-Moon Kim, Kyu-Bong Kim, Jeong-Woong Park, Jae-Young Choi, Jin Hyeog Oh, Ki-Duk Song, Suhkmann Kim, Byung-Wook Cho
Objective: Evaluation of exercise effects in racehorse is important in horseracing industry and animal health care. In this study, we compared metabolic patterns between before and after exercise to screen metabolic biomarkers for exercise effects in thoroughbreds. Methods: The concentration of metabolites in muscle, plasma, and urine was measured by 1H NMR spectroscopy analysis and the relative metabolite levels in the three samples were compared between before and after exercise...
June 27, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28728373/substituting-oat-hay-or-maize-silage-for-portion-of-alfalfa-hay-affects-growth-performance-ruminal-fermentation-and-nutrient-digestibility-of-weaned-calves
#11
Yang Zou, XinPing Zou, XiZhi Li, Gang Guo, Peng Ji, Yan Wang, ShengLi Li, YaJing Wang, ZhiJun Cao
Objective: The impact of forage feeding strategy on growth performance, ruminal fermentation and nutrient digestibility in post-weaning calves was investigated. Methods: Forty-five female Holstein calves (BW = 79.79±0.38 kg) were enrolled in the 35-d study at one week after weaning and randomly assigned to one of three dietary treatments. All diets were fed as total mixed ration containing 60% (DM basis) of basal starter feed and 40% (DM basis) of forage, but varied in composition of forage source including 1) alfalfa (40% DM, AH); 2) alfalfa hay (26...
June 27, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28727906/potential-of-telmisartan-in-the-treatment-of-benign-prostatic-hyperplasia
#12
Ismail Ogunbayode Ishola, Charles C Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U Udokwu
Benign prostatic hyperplasia (BPH) is a common health problem in aging men. This study was carried out to investigate the protective effect of telmisartan on testosterone induced-BPH in rats. Fifty-four male Wistar rats (200 - 250g) were randomly divided into 9 groups (n =6) and orally treated for 28 consecutive days: group 1- vehicle normal, olive oil (10 ml/kg); group 2- BPH model control (10 ml/kg); groups 3-5 - telmisartan (5, 10 or 20 mg/kg, respectively); group 6- pioglitazone (20 mg/kg); group 7- celecoxib (20 mg/kg); group 8- combination of telmisartan (5 mg/kg) and pioglitazone (20 mg/kg); group 9- combination of telmisartan (5 mg/kg) and celecoxib (20 mg/kg)...
July 20, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28727067/compositional-mixed-modeling-of-methane-emissions-and-ruminal-volatile-fatty-acids-from-individual-cattle-and-multiple-experiments
#13
J Palarea-Albaladejo, J A Rooke, I M Nevison, R J Dewhurst
The aim of the study was to investigate the association of methane (CH) yields (g/kg DMI) with rumen VFA molar proportions and animal and diet-related covariates from individual animals and multiple experiments. The dataset available consisted of 284 measurements of CH yields for beef cattle from 6 experiments measured in indirect respiration chambers. A compositional modeling approach was employed where VFA measurements were considered as a whole, instead of in isolation, emphasizing their multivariate relative scale...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727060/effect-of-monensin-inclusion-on-intake-digestion-and-ruminal-fermentation-parameters-by-bos-taurus-indicus-and-bos-taurus-taurus-steers-consuming-bermudagrass-hay
#14
N L Bell, R C Anderson, T R Callaway, M O Franco, J E Sawyer, T A Wickersham
Effects of monensin inclusion and cattle subspecies on utilization of bermudagrass hay (13.7% CP, 77.3% NDF, and 38.8% ADF) were evaluated using ruminally cannulated steers (5 [BI] and 5 [BT]; 398 kg BW). Subspecies were concurrently subjected to a 2-period, 2-treatment crossover design. Treatments were 0 (CON) or 200 mg·steer·d monensin (MON) in 0.91 kg dried distillers' grains with solubles. Periods were 70 d in length: 20 d of adaptation, 22 d of sample collection, and 28 d for withdrawal of treatment...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727043/effect-of-monensin-withdrawal-on-intake-digestion-and-ruminal-fermentation-parameters-by-bos-taurus-indicus-and-bos-taurus-taurus-steers-consuming-bermudagrass-hay
#15
N L Bell, T R Callaway, R C Anderson, M O Franco, J E Sawyer, T A Wickersham
Effects of monensin withdrawal and cattle subspecies on the utilization of bermudagrass hay (14.3% CP, 72.3% NDF, and 36.9% ADF) were evaluated using ruminally cannulated steers (5 [BI] and 5 [BT]). Subspecies were concurrently subjected to a 2-period, 2-treatment crossover design. Treatments consisted of either 0 mg·steer·d-1 monensin with no previous monensin feeding (CON) or withdrawal from 200 mg·steer·d-1 monensin (MON) fed individually in 0.91 kg dried distillers' grains with solubles for 42 d. Withdrawal was evaluated for a 28-d period...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726034/mentally-stimulating-activities-associate-with-better-cognitive-performance-in-parkinson-disease
#16
Jeffrey L B Bohnen, Martijn L T M Müller, Jacob Haugen, Nicolaas I Bohnen
Subjects at risk of dementia benefit from participation in mentally stimulating activities, but no prior studies have investigated similar associations in Parkinson disease (PD). The aim of this study was to investigate the relationship between times spent engaging in mentally stimulating activities and cognitive functions in PD while accounting for the degree of primary neurodegenerations. PD patients (N = 41, 33 males; age 68.5 ± 7.2; Hoehn and Yahr stage 2.6 ± 0.6) completed the Community Health Activities Model Program for Seniors questionnaire, mini-mental state examination (MMSE), and [(11)C]dihydrotetrabenazine dopaminergic and [(11)C]piperidinyl propionate acetylcholinesterase PET imaging...
July 19, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28725974/carbofuran-causes-neuronal-vulnerability-to-glutamate-by-decreasing-glua2-protein-levels-in-rat-primary-cortical-neurons
#17
Kanae Umeda, Masatsugu Miyara, Keishi Ishida, Seigo Sanoh, Shigeru Ohta, Yaichiro Kotake
Glutamate receptor 2 (GluA2/GluR2) is one of the four subunits of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR); an increase in GluA2-lacking AMPARs contributes to neuronal vulnerability to excitotoxicity because of the receptor's high Ca(2+) permeability. Carbofuran is a carbamate pesticide used in agricultural areas to increase crop productivity. Due to its broad-spectrum action, carbofuran has also been used as an insecticide, nematicide, and acaricide. In this study, we investigated the effect of carbofuran on GluA2 protein expression...
July 19, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28725238/a-non-targeted-metabolomics-approach-unravels-the-vocs-associated-with-the-tomato-immune-response-against-pseudomonas-syringae
#18
María Pilar López-Gresa, Purificación Lisón, Laura Campos, Ismael Rodrigo, José Luis Rambla, Antonio Granell, Vicente Conejero, José María Bellés
Volatile organic compounds (VOCs) emitted by plants are secondary metabolites that mediate the plant interaction with pathogens and herbivores. These compounds may perform direct defensive functions, i.e., acting as antioxidant, antibacterial, or antifungal agents, or indirectly by signaling the activation of the plant's defensive responses. Using a non-targeted GC-MS metabolomics approach, we identified the profile of the VOCs associated with the differential immune response of the Rio Grande tomato leaves infected with either virulent or avirulent strains of Pseudomonas syringae DC3000 pv...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28725178/different-forms-of-ampa-receptor-mediated-ltp-and-their-correlation-to-the-spatial-working-memory-formation
#19
Derya R Shimshek, Thorsten Bus, Bettina Schupp, Vidar Jensen, Verena Marx, Liliana E Layer, Georg Köhr, Rolf Sprengel
Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout mice LTP and SWM deficits could be partially recovered by transgenic re-installation of full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site truncated GFP-GluA1(TG)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28723625/2-acetylamino-3-4-2-acetylamino-2-carboxyethylsulfanylcarbonylamino-phenyl-carbamoylsulfanyl-propionic-acid-a-glutathione-reductase-inhibitor-induces-g2-m-cell-cycle-arrest-through-generation-of-thiol-oxidative-stress-in-human-esophageal-cancer-cells
#20
Xia Li, Zhiming Jiang, Jianguo Feng, Xiaoying Zhang, Junzhou Wu, Wei Chen
Esophageal squamous cell carcinoma (ESCC) is a highly malignant cancer with poor response to both of chemotherapy and radiotherapy. 2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid (2-AAPA), an irreversible inhibitor of glutathione reductase (GR), is able to induce intracellular oxidative stress, and has shown anticancer activity in many cancer cell lines. In this study, we investigated the effects of 2-AAPA on the cell proliferation, cell cycle and apoptosis and aimed to explore its mechanism of action in human esophageal cancer TE-13 cells...
June 27, 2017: Oncotarget
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