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https://www.readbyqxmd.com/read/28528362/budesonide-fluticasone-propionate-and-azithromycin-do-not-modulate-the-membrane-vesicle-release-by-thp-1-macrophages-and-respiratory-pathogens-during-macrophage-infection
#1
Charlotte Volgers, Gert E Grauls, Pauline H M Hellebrand, Paul H M Savelkoul, Frank R M Stassen
Patients with more severe chronic obstructive pulmonary disease frequently experience exacerbations and it is estimated that up to 50% of these exacerbations are associated with bacterial infections. The mainstay treatment for these infection-related exacerbations constitutes the administration of glucocorticoids, alone or in combination with antibiotics. A recent line of evidence demonstrates that many hormones including the steroid beclomethasone can also directly affect bacterial growth, virulence, and antibiotic resistance...
May 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28524719/polyester-based-microdisc-systems-for-sustained-release-of-neuroprotective-phosphine-borane-complexes
#2
David A Janus, Christopher J Lieven, Megan E Crowe, Leonard A Levin
Phosphine-borane complexes are recently developed redox-active drugs that are neuroprotective in models of optic nerve injury and radioprotective in endothelial cells. However, a single dose of these compounds is short-lived, necessitating development of sustained-release formulations of these novel molecules. We screened a library of biodegradable co- and non-block polyester polymer systems for release of incorporated phosphine-borane complexes to evaluate them as drug delivery systems for use in chronic disease...
May 19, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28524071/flexible-low-cost-sensor-based-on-electrolyte-gated-carbon-nanotube-field-effect-transistor-for-organo-phosphate-detection
#3
Vijay Deep Bhatt, Saumya Joshi, Markus Becherer, Paolo Lugli
A flexible enzymatic acetylcholinesterase biosensor based on an electrolyte-gated carbon nanotube field effect transistor is demonstrated. The enzyme immobilization is done on a planar gold gate electrode using 3-mercapto propionic acid as the linker molecule. The sensor showed good sensing capability as a sensor for the neurotransmitter acetylcholine, with a sensitivity of 5.7 μA/decade, and demonstrated excellent specificity when tested against interfering analytes present in the body. As the flexible sensor is supposed to suffer mechanical deformations, the endurance of the sensor was measured by putting it under extensive mechanical stress...
May 18, 2017: Sensors
https://www.readbyqxmd.com/read/28522404/tubo-ovarian-abscess-in-a-virginal-adolescent-with-labial-agglutination-due-to-lichen-sclerosus
#4
Bianca Stortini, Ozlem Dural, Maria Kielly, Nathalie Fleming
BACKGROUND: We describe an unusual presentation of lichen sclerosus in a postmenarchal, virginal girl. CASE: A 14 year-old girl first presented with acute urinary retention due to labial agglutination and developed bilateral tubo-ovarian abscesses in 10 days of the conservative management period. Abscesses were treated with antibiotherapy and percutaneous drainage; simple division of the labial agglutination and vulvar biopsies were performed with a preliminary diagnosis of lichen sclerosus...
May 15, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28521862/bile-acid-binding-resin-prevents-fat-accumulation-through-intestinal-microbiota-in-high-fat-diet-induced-obesity-in-mice
#5
Yukie Kusumoto, Junichiro Irie, Kaho Iwabu, Hirotsune Tagawa, Arata Itoh, Mari Kato, Nana Kobayashi, Kumiko Tanaka, Rieko Kikuchi, Masataka Fujita, Yuya Nakajima, Kohkichi Morimoto, Taichi Sugizaki, Satoru Yamada, Toshihide Kawai, Mitsuhiro Watanabe, Yuichi Oike, Hiroshi Itoh
BACKGROUND: Bile acid binding resin (BAR) absorbs intestinal bile acids, and improves obesity and metabolic disorders, but the precise mechanism remains to be clarified. Recent findings reveal that obesity is associated with skewed intestinal microbiota. Thus, we investigated the effect of BAR on intestinal microbiota and the role of microbiota in the prevention of obesity in high-fat diet-induced obesity in mice. PROCEDURES: Male Balb/c mice were fed a low-fat diet (LFD), high-fat diet (HFD), or HFD with BAR (HFD+BAR), and then metabolic parameters, caecal microbiota, and metabolites were investigated...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28518087/multimer-page-a-method-for-capturing-and-resolving-protein-complexes-in-biological-samples
#6
Tyler Rhinesmith, Bryan A Killinger, Akhil Sharma, Anna Moszczynska
There are many well-developed methods for purifying and studying single proteins and peptides. However, most cellular functions are carried out by networks of interacting protein complexes, which are often difficult to investigate because their binding is non-covalent and easily perturbed by purification techniques. This work describes a method of stabilizing and separating native protein complexes from unmodified tissue using two-dimensional polyacrylamide gel electrophoresis. Tissue lysate is loaded onto a non-denaturing blue-native polyacrylamide gel, then an electric current is applied until the protein migrates a short distance into the gel...
May 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28511603/clinical-experience-with-perampanel-for-refractory-pediatric-epilepsy-in-one-canadian-center
#7
Anita N Datta, Qi Xu, Shafina Sachedina, Cyrus Boelman, Linda Huh, Mary B Connolly
Perampanel (PER) is a new antiseizure medication that inhibits the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) class of glutamate receptors. It is important for physicians to be aware of the efficacy and tolerability of new drugs in the postmarketing phase. We performed a retrospective review of our experience with perampanel at BC Children's Hospital. Twenty-four pediatric patients prescribed perampanel from 2014 to 2016 were identified. Fifteen (63%) discontinued perampanel, and 10 (42%) had greater than 50% reduction in seizures...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28510491/short-term-growth-during-treatment-with-inhaled-fluticasone-propionate-formoterol-fluticasone-and-beclomethasone-treatment
#8
Ole D Wolthers, Ainslee Moore, Sabine Mersmann, Sanjeeva Dissanayake
BACKGROUND: Fluticasone propionate/formoterol (FP/FORM) is a pressurized metered-dose inhaler (pMDI; Flutiform(®)) approved for use in adolescents and adults and under development for pediatric use. OBJECTIVE: To compare short-term growth in asthmatic children treated with FP/FORM, FP pMDI with valved holding chamber, and beclomethasone dipropionate (BDP) in a breath-actuated device. METHODS: Children with persistent asthma (n = 48; 5 to <12 years) participated in an assessor-blinded, randomized, three-way crossover trial with run in, wash out, and active treatment periods, each of 2 weeks duration...
May 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28508151/tunable-and-nontoxic-fluorescent-probes-based-on-carbon-dots-for-imaging-of-indole-propionic-acid-receptor-in-plant-tissues-in-situ
#9
Bixia Lin, Ying Yu, Fangfei Liu, Yujuan Cao, Manli Guo
Indole propionic acid (IPA) is one of the important plant growth hormones for promoting rooting and fruiting. Labeling IPA receptor in plant tissues is able to further track the signal transduction processes of IPA and uncover the function mechanism of IPA on crop productions. In this paper, a tunable and nontoxic fluorescent probe for IPA receptors was designed and synthetized base on carbon dots (C dots). Firstly carboxyl-modified carbon dots were prepared by high temperature cracking of citric acid. The fluorescence emission wavelengths of C dots varied with the excitation wavelengths change...
May 15, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28505492/comprehensive-evaluation-of-scfa-production-in-the-intestinal-bacteria-regulated-by-berberine-using-gas-chromatography-combined-with-polymerase-chain-reaction
#10
Lu-Lu Wang, Hui-Hui Guo, Shuai Huang, Chen-Lin Feng, Yan-Xing Han, Jian-Dong Jiang
Short-chain fatty acids (SCFAs) of intestine microbial have caught accumulating attention for their beneficial effects on human health. Botanic compounds with low bioavailability such as berberine (BBR) and resveratrol might interact with intestinal microbial ecosystem and promote gut bacteria to produce SCFA, which contribute to their biological effects. In the present study, a comprehensive assay system was built to detect SCFAs production in intestinal bacteria, in which stringent anaerobic culture was applied for in vitro bacterial fermentation, followed by direct-injection GC detection (chemical detection) in combination with real time polymerase chain reaction (RT-PCR, biological detection)...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28504720/a-clinical-drug-library-screen-identifies-clobetasol-propionate-as-an-nrf2-inhibitor-with-potential-therapeutic-efficacy-in-keap1-mutant-lung-cancer
#11
E-J Choi, B-J Jung, S-H Lee, H-S Yoo, E-A Shin, H-J Ko, S Chang, S-Y Kim, S-M Jeon
The Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor E2-related factor 2 (NRF2)pathway has a central role in cellular antioxidant defense. NRF2 activation due to KEAP1 or NRF2 mutations occurs frequently in many cancers, suggesting that NRF2 inhibition could be a promising therapeutic strategy. However, no potent NRF2 inhibitors are clinically available to date. To develop potent NRF2 inhibitors for therapeutic purpose, we screened ~4000 clinical compounds and determined clobetasol propionate (CP) as the most potent NRF2 inhibitor...
May 15, 2017: Oncogene
https://www.readbyqxmd.com/read/28504280/metabolic-profile-and-underlying-improved-bio-activity-of-fructus-aurantii-immaturus-by-human-intestinal-bacteria
#12
Xing Yan Liu, Meng Lin Fan, Huai You Wang, Bo Yang Yu, Ji Hua Liu
Fructus aurantii immaturus (FAI) is the dried young fruit of Citrus aurantium L. or Citrus sinensis L. Osbeck. The purpose of this paper was to investigate the metabolic fate of FAI upon incubation with human intestinal bacteria, meanwhile to evaluate the antioxidant and anti-inflammatory activities of FAI and the transformed Fructus aurantii immaturus (TFAI). The water extract of FAI was anaerobically incubated with human intestinal bacterial suspensions for 48 h at 37 °C. Liquid chromatography-hybridised with quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS) was applied to identify FAI metabolites...
May 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28504143/thermal-and-mechanical-properties-of-tailor-made-unbranched-%C3%AE-1-3-glucan-esters-with-various-carboxylic-acid-chain-length
#13
Sakarin Puanglek, Satoshi Kimura, Tadahisa Iwata
The convenient and environmentally friendly method for in vitro polymerization catalyzed by glucosyltransferase, designated as GtfJ, extracted from recombinant E. Coli was used to synthesize tailor-made α-1,3-glucan (α-1,3-d-glucan) having moderate molecular weight (Mw=2.0×10(5)) and no branches. With the aim to improve thermoplasticity of this polysaccharide, after in vitro synthesis, chemical modification by acylation was selected and then fully substituted α-1,3-glucan esters were successfully obtained via both homogeneous and heterogeneous methods...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28504130/bifidobacterial-growth-stimulation-by-oligosaccharides-generated-from-olive-tree-pruning-biomass
#14
Encarnación Ruiz, Beatriz Gullón, Patrícia Moura, Florbela Carvalheiro, Gemma Eibes, Cristóbal Cara, Eulogio Castro
This work aims to evaluate the prebiotic potential of oligosaccharides (OS) obtained from autohydrolysis of olive tree pruning biomass (OTPB). Two selected fractions (F1 and F2) were characterized and used in in vitro fermentations by two Bifidobacterium spp. (B. adolescentis and B. longum) and one fecal inoculum. The fraction F1 presented a lower average degree of polymerization (DP) mainly with OS ranging from 3 to 6 DP, whereas the fraction F2 corresponded to a pool of unsubstituted and acetylated oligomers with DP between 4 and 19...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28503807/reducing-anti-nutritional-factor-and-enhancing-yield-with-advancing-time-of-planting-and-zinc-application-in-grasspea-in-ethiopia
#15
Ashutosh Sarker, Asnake Fikre, Ali M Abd El-Moneim, Hani Nakkoul, Murari Singh
BACKGROUND: Grasspea (Lathyrus sativus L.), an important pulse crop in food, feed and for sustainable crop production systems in Ethiopia. Despite its advantage on nutrition and adaptability to harsh climate and low fertile soil, it contains a neurotoxin β - N - Oxalyl α β diamiono propionic acid (β-ODAP) which paralyzes the lower limbs and is affected by genotypic and agronomic factors. The effect of zinc application and planting date on yield and β- ODAP content of two genotypes, experiments were conducted in two regions of Ethiopia...
May 15, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28501409/effect-of-different-fat-supplements-on-performance-of-dairy-calves-during-cold-season
#16
E Ghasemi, M Azad-Shahraki, M Khorvash
The objective of this experiment was to evaluate the effects of starter supplementation with fat sources differing in their fatty acid (FA) profile on performance of dairy calves during cold season. Sixty Holstein calves (3 d of age; 39.7 ± 3.8 kg of body weight) were randomly assigned to 1 of 5 starter diets supplemented with (1) no fat or oil source (control), (2) 3% palm fat (PLF), (3) 3% soybean oil (SBO), (4) 3% tallow (TAL), and (5) a 3.2% mixture (MIX) of PLF, SBO, and fish oil. The fat supplements were substituted for corn in the basal starter diet...
May 10, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28500706/common-structural-elements-in-the-chromophore-binding-pocket-of-the-pfr-state-of-bathy-phytochromes
#17
Francisco Velázquez Escobar, David Buhrke, Norbert Michael, Luisa Sauthof, Svea Wilkening, Neslihan N Tavraz, Johannes Salewski, Nicole Frankenberg-Dinkel, Maria Andrea Mroginski, Patrick Scheerer, Thomas Friedrich, Friedrich Siebert, Peter Hildebrandt
Phytochromes are bimodal photoreceptors which, upon light absorption by the tetrapyrrole chromophore, can be converted between a red-absorbing state (Pr) and far-red-absorbing state (Pfr). In bacterial phytochromes, either Pr or Pfr are the thermally stable states, thereby constituting the classes of prototypical and bathy phytochromes, respectively. In this work, we have employed vibrational spectroscopies to elucidate the origin of the thermal stability of the Pfr states in bathy phytochromes. Here, we present the first detailed spectroscopic analysis of RpBphP6 (Rhodopseudomas palustris), which together with results obtained for Agp2 (Agrobacterium tumefaciens) and PaBphP (Pseudomonas aeruginosa) allows identifying common structural properties of the Pfr state of bathy phytochromes, which are (1) a homogenous chromophore structure, (2) the protonated ring C propionic side chain of the chromophore and (3) a retarded H/D exchange at the ring D nitrogen...
May 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28497116/ph-mediated-microbial-and-metabolic-interactions-in-fecal-enrichment-cultures
#18
Zehra Esra Ilhan, Andrew K Marcus, Dae-Wook Kang, Bruce E Rittmann, Rosa Krajmalnik-Brown
pH and fermentable substrates impose selective pressures on gut microbial communities and their metabolisms. We evaluated the relative contributions of pH, alkalinity, and substrate on microbial community structure, metabolism, and functional interactions using triplicate batch cultures started from fecal slurry and incubated with an initial pH of 6.0, 6.5, or 6.9 and 10 mM glucose, fructose, or cellobiose as the carbon substrate. We analyzed 16S rRNA gene sequences and fermentation products. Microbial diversity was driven by both pH and substrate type...
May 2017: MSphere
https://www.readbyqxmd.com/read/28493444/impact-of-hyperlipidaemia-on-intermediary-metabolism-faecal-microbial-metabolites-and-urinary-characteristics-of-lipoprotein-lipase-deficient-vs-normal-cats
#19
N Paßlack, J Zentek, J A Larsen, J L Westropp, A J Fascetti
Findings in humans and rats indicate that hyperlipidaemia may be associated with enhanced endogenous oxalate (Ox) synthesis, which may be relevant for calcium oxalate (CaOx) urolith formation. Moreover, changes in lipid metabolism are proposed to negatively affect gut microbiota. This study aimed to investigate those potential interactions in hyperlipidaemic cats. Therefore, 10 normal control cats and seven lipoprotein lipase (LPL)-deficient cats were fed a low-fat diet for seven weeks. During the last week of the study, cats were housed in metabolic cages to collect urine and faeces...
May 11, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28492586/-risk-of-pneumonia-during-long-term-regular-treatment-of-stable-copd-with-inhaled-glucocorticoids-a-systematic-review
#20
Fabio Arpinelli, Gaetano Caramori, Maria Sandra Magnoni
Inhaled glucocorticoids are anti-inflammatory drugs used in combination with long acting bronchodilators beta2-agonists for the treatment of stable chronic obstructive pulmonary disease (COPD), to improve lung function and symptoms and to reduce the future risk COPD exacerbations. However, has been also associated to an increased risk of pneumonia. The objective of this systematic review was therefore to analyze all randomized controlled trials to identify the risk of pneumonia during the regular treatment with long-term inhaled glucocorticosteroids compared to treatment with placebo in patients with stable COPD...
April 2017: Recenti Progressi in Medicina
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