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https://www.readbyqxmd.com/read/27924509/inhibitory-effect-of-diosgenin-on-experimentally-induced-benign-prostatic-hyperplasia-in-rats
#1
Jing Chen, Huai-Fen Zhang, Chao-Mei Xiong, Jin-Lan Ruan
This study investigated the effect of diosgenin, a natural sapogenin possessing various pharmacological activities, on benign prostatic hyperplasia (BPH) in rats and the possible mechanisms. BPH was established in the castrated rats by subcutaneous injection of testosterone propionate. Animals were randomly divided into four groups (n=10 each): model group (0.5% sodium carboxymethyl cellulose); positive control group (3 mg/kg finasteride); two diosgenin groups (50 and 100 mg/kg). The drugs were intragastricaly given in each group for consecutive 3 weeks...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27924402/age-related-response-of-rumen-microbiota-to-mineral-salt-and-effects-of-their-interactions-on-enteric-methane-emissions-in-cattle
#2
C Liu, X H Li, Y X Chen, Z H Cheng, Q H Duan, Q H Meng, X P Tao, B Shang, H M Dong
Mineral salt bricks are often used in cow raising as compensation for mineral losses to improve milk yield, growth, and metabolic activity. Generally, effects of minerals are partially thought to result from improvement of microbial metabolism, but their influence on the rumen microbiota has rarely been documented to date. In this study, we investigated the response of microbiota to mineral salt in heifer and adult cows and evaluated ruminal fermentation and enteric methane emissions of cows fed mineral salts...
December 6, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27924323/the-use-of-a-quartz-crystal-microbalance-as-an-analytical-tool-to-monitor-particle-surface-and-particle-particle-interactions-under-dry-ambient-and-pressurized-conditions-a-study-using-common-inhaler-components
#3
N W Turner, M Bloxham, S A Piletsky, M J Whitcombe, I Chianella
Metered dose inhalers (MDI) and multidose powder inhalers (MPDI) are commonly used for the treatment of chronic obstructive pulmonary diseases and asthma. Currently, analytical tools to monitor particle/particle and particle/surface interaction within MDI and MPDI at the macro-scale do not exist. A simple tool capable of measuring such interactions would ultimately enable quality control of MDI and MDPI, producing remarkable benefits for the pharmaceutical industry and the users of inhalers. In this paper, we have investigated whether a quartz crystal microbalance (QCM) could become such a tool...
December 7, 2016: Analyst
https://www.readbyqxmd.com/read/27921362/effects-of-mineral-salt-supplement-on-enteric-methane-emissions-ruminal-fermentation-and-methanogen-community-of-lactating-cows
#4
Xiaohua Li, Chong Liu, Yongxing Chen, Rongguang Shi, Zhenhua Cheng, Hongmin Dong
We evaluated the effects of mineral salt supplement on enteric methane emissions, ruminal fermentation and methanogen community of dairy cows over a whole lactation period. Ten Holstein cows fed a total mixed ration (TMR) diet were randomly allocated into two groups, one supplied with mineral salts as the treatment group and the other as the control group. The methane measurement showed that the ingestion of mineral salts lowered enteric methane emissions significantly (P < 0.05), with an average of 10...
December 6, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27919660/a-comparison-of-vasodilation-mode-among-selexipag-ns-304-2-4-5-6-diphenylpyrazin-2-yl-isopropyl-amino-butoxy-n-methylsulfonyl-acetamide-its-active-metabolite-mre-269-and-various-prostacyclin-receptor-agonists-in-rat-porcine-and-human-pulmonary-arteries
#5
Chiaki Fuchikami, Kohji Murakami, Koyuki Tajima, Junko Homan, Keiji Kosugi, Kazuya Kuramoto, Michiko Oka, Keiichi Kuwano
Selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N- (methylsulfonyl)acetamide]) is a novel, orally available non-prostanoid prostacyclin receptor (IP receptor) agonist that has recently been approved for the treatment of pulmonary arterial hypertension (PAH). We examined the effect of the active metabolite of selexipag, MRE-269, and IP receptor agonists that are currently available as PAH therapeutic drugs on the relaxation of rat, porcine and human pulmonary artery. cAMP formation in human pulmonary artery smooth muscle cells was induced by all test compounds (MRE-269, epoprostenol, iloprost, treprostinil and beraprost sodium) and suppressed by IP receptor antagonists (CAY10441 and 2-[4-(1H-indol-4-yloxymethyl)-benzyloxycarbonylamino]-3-phenyl-propionic acid)...
December 2, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27918547/optical-inactivation-of-synaptic-ampa-receptors-erases-fear-memory
#6
Kiwamu Takemoto, Hiroko Iwanari, Hirobumi Tada, Kumiko Suyama, Akane Sano, Takeharu Nagai, Takao Hamakubo, Takuya Takahashi
The synaptic delivery of neurotransmitter receptors, such as GluA1 AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, mediates important processes in cognitive function, including memory acquisition and retention. Understanding the roles of these receptors has been hampered by the lack of a method to inactivate them in vivo with high spatiotemporal precision. We developed a technique to inactivate synaptic GluA1 AMPA receptors in vivo using chromophore-assisted light inactivation (CALI)...
December 5, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27917167/potential-for-sulfate-reduction-in-mangrove-forest-soils-comparison-between-two-dominant-species-of-the-americas
#7
Melike Balk, Joost A Keuskamp, Hendrikus J Laanbroek
Avicennia and Rhizophora are globally occurring mangrove genera with different traits that place them in different parts of the intertidal zone. It is generally accepted that the oxidizing capacity of Avicennia roots is larger than that of Rhizophora roots, which initiates more reduced conditions in the soil below the latter genus. We hypothesize that the more reduced conditions beneath Rhizophora stands lead to more active sulfate-reducing microbial communities compared to Avicennia stands. To test this hypothesis, we measured sulfate reduction traits in soil samples collected from neighboring Avicennia germinans and Rhizophora mangle stands at three different locations in southern Florida...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27915587/the-determination-of-testosterone-esters-and-estradiol-esters-in-bovine-and-porcine-blood-serum
#8
Martina Rejtharová, Libor Rejthar, Katarína Čačková
Monitoring of steroid esters in blood serum is desirable in order to detect possible illegal use of natural hormones as growth promoters. A method for determination of testosterone propionate, testosterone benzoate, testosterone isocaproate, testosterone decanoate and estradiol benzoate in bovine and porcine blood serum was developed. The procedure consists of protein precipitation and removal of phospholipids using a HybridSPE®-Phospholipid column followed by clean-up on a hydrophilic modified styrene polymer Supel(TM) -Select HLB column and LC-MS/MS measurement...
December 5, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27914782/co-metabolism-of-substrates-by-bacillus-thuringiensis-regulates-polyhydroxyalkanoate-co-polymer-composition
#9
Subhasree Ray, Vipin Chandra Kalia
Polyhydroxyalkanoate (PHA) production by Bacillus thuringiensis EGU45 was studied by co-metabolism of crude glycerol (CG) (1%, v/v), glucose (0.05-0.5%, w/v) and propionic acid (0.05-0.5%, v/v) under batch (shake flask) culture conditions. Glycerol+PA combination resulted in 15-100mg/L PHA co-polymers with a HV content of 33-81mol%. The addition of NH4Cl (0.5%, w/v) to CG+PA enhanced PHA production by 1.55-fold, with a HV content of 58-70mol%. The time period of incubation of PA to the feed: CG+glucose was optimized to be 3h after initiation of fermentation...
November 23, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27913852/differential-effect-of-early-antibiotic-intervention-on-bacterial-fermentation-patterns-and-mucosal-gene-expression-in-the-colon-of-pigs-under-diets-with-different-protein-levels
#10
Chuanjian Zhang, Miao Yu, Yuxiang Yang, Chunlong Mu, Yong Su, Weiyun Zhu
The study aimed to evaluate the effects of early antibiotic intervention (EAI) on bacterial fermentation patterns and mucosal immune markers in the colon of pigs with different protein level diets. Eighteen litters of piglets at day (d) 7 were fed creep feed without or with growth promoting antibiotics until d 42. At d 42, pigs within each group were further randomly assigned to a normal- or low-crude protein (CP) diet. At d 77 and d 120, five pigs per group were slaughtered for analyzing colonic bacteria, metabolites, and mucosal gene expressions...
December 3, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27913032/intervention-studies-of-inhaled-corticosteroids-combined-with-long-acting-theophylline-or-long-acting-%C3%AE-2-agonists-in-patients-with-moderate-to-severe-asthma-a-randomized-controlled-study
#11
Yan Wang, Ping Chen, Anna Dai, Shengyun Shang, Lingfei Kong
PURPOSE: To evaluate and contrast the therapeutic effect and safety of fluticasone aerosol combined with theophylline tablets in patients with moderate to severe asthma, compared with salmeterol/fluticasone propionate aerosol. METHODS: After a screening period, patients meeting the inclusion criteria were randomly assigned to the experiment group (fluticasone aerosol combined with theophylline tablets) or the control group (salmeterol/fluticasone aerosol combined with placebo tablets) for 12 weeks of treatment...
November 29, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27910937/biohydrogen-production-from-enzymatic-hydrolysis-of-food-waste-in-batch-and-continuous-systems
#12
Wei Han, Yingting Yan, Yiwen Shi, Jingjing Gu, Junhong Tang, Hongting Zhao
In this study, the feasibility of biohydrogen production from enzymatic hydrolysis of food waste was investigated. Food waste (solid-to-liquid ratio of 10%, w/v) was first hydrolyzed by commercial glucoamylase to release glucose (24.35 g/L) in the food waste hydrolysate. Then, the obtained food waste hydrolysate was used as substrate for biohydrogen production in the batch and continuous (continuous stirred tank reactor, CSTR) systems. It was observed that the maximum cumulative hydrogen production of 5850 mL was achieved with a yield of 245...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27906983/tithonia-diversifolia-as-a-supplementary-feed-for-dairy-cows
#13
Rafael Sandin Ribeiro, Stephanie Amelia Terry, João Paulo Sacramento, Sylvia Rocha E Silveira, Cláudia Braga Pereira Bento, Elsa Fernandes da Silva, Hilário Cuquetto Mantovani, Marco Antônio Sundfeld da Gama, Luiz Gustavo Ribeiro Pereira, Thierry Ribeiro Tomich, Rogério Martins Maurício, Alexandre Vieira Chaves
The objective of this study was to examine the effects of Tithonia diversifolia as a supplementary forage on dairy cow performance and methane production. Nine lactating Holstein × Zebu dairy cows (519 ± 53.3 kg of body weight and 66 ± 13.3 d in milk) were paired by milk yield (21.3 ± 2.34 kg/d) and body weight and randomly assigned to three dietary treatments in a Latin square design with 21-d experimental periods (14 d for diet adaptation and 7 d for measurements and sample collection). The dietary treatments included the control diet consisting of fresh sugar cane plus concentrate (44:56, % of diet DM), and two treatment diets containing different levels of fresh T...
2016: PloS One
https://www.readbyqxmd.com/read/27905542/defining-an-olfactory-receptor-function-in-airway-smooth-muscle-cells
#14
William H Aisenberg, Jessie Huang, Wanqu Zhu, Premraj Rajkumar, Randy Cruz, Lakshmi Santhanam, Niranjana Natarajan, Hwan Mee Yong, Breann De Santiago, Jung Jin Oh, A-Rum Yoon, Reynold A Panettieri, Oliver Homann, John K Sullivan, Stephen B Liggett, Jennifer L Pluznick, Steven S An
Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM) mass and cellular remodeling that occur in asthma are not well defined. Here we report the expression of odorant receptors (ORs) belonging to the superfamily of G-protein coupled receptors (GPCRs), as well as the canonical olfaction machinery (Golf and AC3) in the smooth muscle of human bronchi. In primary cultures of isolated human ASM, we identified mRNA expression for multiple ORs. Strikingly, OR51E2 was the most highly enriched OR transcript mapped to the human olfactome in lung-resident cells...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904282/betamethasone-butyrate-propionate-inhibits-the-induction-of-thymic-stromal-lymphopoietin-in-cultured-normal-human-keratinocytes
#15
Wei Zhang, Takashi Sakai, Yutaka Hatano, Sakuhei Fujiwara
No abstract text is available yet for this article.
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27902914/inactivation-of-avian-influenza-virus-in-nonpelleted-chicken-feed
#16
H Toro, V L van Santen, C Breedlove
Corn stored outside could become contaminated with avian influenza virus (AIV) from wild bird droppings. AIV-contaminated ingredients could pass into the poultry flocks in nonpelleted chicken feed. The efficacy of two disinfectants at inactivating AIV in chicken feed was evaluated. Both Termin-8 (a blend of formaldehyde, propionic acid, terpenes, and surfactant) and Finio (a blend of approved phytochemicals and carboxylic acids) effectively inactivated AIV in chicken feed. Because stability of infectious AIV in chicken feed is limited, we evaluated addition of protein (skim milk powder) to the virus suspension...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902335/defluviitalea-raffinosedens-sp-nov-a-novel-thermophilic-anaerobic-saccharolytic-bacterium-isolated-from-an-anaerobic-batch-digester-treating-animal-manure-and-rice-straw
#17
Shichun Ma, Yan Huang, Cong Wang, Hui Fan, Lirong Dai, Zheng Zhou, Xing Liu, Yu Deng
A thermophilic, anaerobic, fermentative bacterium, strain A6T, was obtained from an anaerobic batch digester treating animal manure and rice straw. The strain was Gram-positive, slightly curved rods with a size of 0.6-1 μm × 2.5-8.2 μm, non-motile, and produced terminal spores. The temperature, pH, and NaCl concentration ranges for growth were 40°C-60°C, 6.5-8.0, and 0-15.0 g/L, with optimum growth noted at 50°C-55°C, pH 7.5, and in the absence of NaCl, respectively. Yeast extract was required for growth...
November 14, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902225/desulfobulbus-oligotrophicus-sp-nov-a-novel-sulfate-reducing-and-propionate-oxidizing-bacterium-isolated-from-a-municipal-anaerobic-sewage-sludge-digester
#18
Abdelaziz El Houari, Magali Ranchou-Peyruse, Anthony Ranchou-Peyruse, Adrien Dakdaki, Marion Guignard, Lahcen Idouhammou, Rhizlane Bennisse, Radia Bouterfass, Rémy Guyoneaud, Abdel-Illah Qatibi
A novel, mesophilic, strictly anaerobic, sulfate-reducing and propionate-oxidizing bacterium, strain Prop6T, was enriched and isolated from a municipal anaerobic sewage sludge digester. Cells were Gram-negative, catalase-positive, oval rods, motile by means of amphitrichous flagella, non-spore-forming and contained menaquinone MK-5(H2) as the major respiratory quinone. The genomic DNA G+C content was 51.7 mol%. The optimal NaCl concentration, temperature and pH were 2-5 g l-1, 35°C and 7.6, respectively. Strain Prop6T could only oxidize propionate, lactate and pyruvate (weakly) with sulfate, sulfite or thiosulfate, mainly to acetate...
October 27, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900673/expansion-of-the-phenotypic-spectrum-of-propionic-acidemia-with-isolated-elevated-propionylcarnitine
#19
Gerarda Cappuccio, Paldeep S Atwal, Taraka R Donti, Kiki Ugarte, Nadia Merchant, William J Craigen, V Reid Sutton, Sarah H Elsea
We report three patients with elevations of propionylcarnitine (C3), one without elevations of 2-methylcitrate and 3-hydroxypropionate in urine organic acid analysis, and the other two showing only mild elevations, all of whom were subsequently confirmed to have propionic acidemia by molecular analysis of PCCA and PCCB genes. To date, they have had a mild clinical course. These cases illustrate the importance of considering high C3 as the only biochemical abnormality in a diagnosis of propionic acidemia. Since mild C3 elevations may be overlooked and considered non-diagnostic in isolation, we advise considering a diagnosis of propionic acidemia even in the absence of significant elevations 2-methylcitrate or 3-hydroxypropionate in urine organic acid analysis...
November 30, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27899919/fermentation-of-ammonia-fiber-expansion-treated-and-untreated-barley-straw-in-a-rumen-simulation-technique-using-rumen-inoculum-from-cattle-with-slow-versus-fast-rate-of-fiber-disappearance
#20
Candace L Griffith, Gabriel O Ribeiro, Masahito Oba, Tim A McAllister, Karen A Beauchemin
The purpose of this study was to determine the effect of rumen inoculum from heifers with fast vs. slow rate of in situ fiber digestion on the fermentation of complex versus easily digested fiber sources in the forms of untreated and Ammonia Fiber Expansion (AFEX) treated barley straw, respectively, using an artificial rumen simulation technique (Rusitec). In situ fiber digestion was measured in a previous study by incubating untreated barley straw in the rumen of 16 heifers fed a diet consisting of 700 g/kg barley straw and 300 g/kg concentrate...
2016: Frontiers in Microbiology
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