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Propionate

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https://www.readbyqxmd.com/read/29155202/bioactive-polysaccharides-and-oligosaccharides-as-possible-feed-additives-to-manipulate-rumen-fermentation-in-rusitec-fermenters
#1
Zongjun Li, Hanxun Bai, Lixin Zheng, Huai Jiang, Huiying Cui, Yangchun Cao, Junhu Yao
Bioactive polysaccharides and oligosaccharides (POSs) have been used as safe non-antibiotic alternatives in animal diets; however, only limited data are available on their effects in rumen manipulation. This study was undertaken to systematically evaluate and compare the efficacies of six different bioactive POSs (10g/kg diet) with respect to ruminal fermentation, feed digestibility, biohydrogenation and bacterial population using a rumen simulation technique. The experiment consisted of 4 independent 12-d incubation periods (each including 8 d for acclimation, followed with 4 d for sample collection)...
November 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29153845/identification-of-abc-transporters-acting-in-vitamin-b12-metabolism-in-caenorhabditis-elegans
#2
Megan K McDonald, Julie-Anne Fritz, Dongxin Jia, Deborah Scheuchner, Floyd F Snyder, Avalyn Stanislaus, Jared Curle, Liang Li, Sally P Stabler, Robert H Allen, Paul E Mains, Roy A Gravel
Vitamin B12 (cobalamin, Cbl) is a micronutrient essential to human health. Cbl is not utilized as is but must go through complex subcellular and metabolic processing to generate two cofactor forms: methyl-Cbl for methionine synthase, a cytosolic enzyme; and adenosyl-Cbl for methylmalonyl-CoA mutase, a mitochondrial enzyme. Some 10-12 human genes have been identified responsible for the intracellular conversion of Cbl to cofactor forms, including genes that code for ATP-binding cassette (ABC) transporters acting at the lysosomal and plasma membranes...
November 11, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29153644/propionic-acid-production-from-soy-molasses-by-propionibacterium-acidipropionici-fermentation-kinetics-and-economic-analysis
#3
Hopen Yang, Zhongqiang Wang, Meng Lin, Shang-Tian Yang
Propionic acid (PA) is a specialty chemical; its calcium salt is widely used as food preservative. Soy molasses (SM), a low-value byproduct from soybean refinery, contains sucrose and raffinose-family oligosaccharides (RFO), which are difficult to digest for most animals and industrial microorganisms. The feasibility of using SM for PA production by P. acidipropionici, which has genes encoding enzymes necessary for RFO hydrolysis, was studied. With corn steep liquor as the nitrogen source, stable long-term PA production from SM was demonstrated in sequential batch fermentations, achieving PA productivity of >0...
November 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29152318/gut-microbiota-composition-may-relate-to-weight-loss-rate-in-obese-pet-dogs
#4
Ida N Kieler, Shamrulazhar Shamzir Kamal, Anne D Vitger, Dennis S Nielsen, Charlotte Lauridsen, Charlotte R Bjornvad
Obese dogs seem to have a different gut microbiome (GM) composition compared to lean dogs, and in humans, GM composition may negatively impact the ability to lose weight in some individuals. The purpose of this study was to investigate the interaction between exercise, weight-loss and the composition of GM in dogs. Eighteen obese pet dogs were recruited for a 12-week weight-loss intervention. All dogs were fed restrictively with a commercial high-protein/high-fibre dry diet, and eight of these dogs were enrolled in an exercise program in addition to the diet intervention...
November 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29152242/comparative-assessment-of-canine-origin-lactobacillus-johnsonii-cpn23-and-dairy-origin-lactobacillus-acidophillus-ncdc-15-for-nutrient-digestibility-faecal-fermentative-metabolites-and-selected-gut-health-indices-in-dogs
#5
Sachin Kumar, Ashok K Pattanaik, Shalini Sharma, Reema Gupta, Sunil E Jadhav, Narayan Dutta
The present experiment was undertaken to validate a probiotic of canine origin for its potential use in dogs. A total of fifteen adult female Labrador dogs were allocated to three equal groups and fed a basal diet without probiotic (control) or with probiotic of either canine (Lactobacillus johnsonii CPN23; cPRO) or dairy (L. acidophilus NCDC 15; dPRO) origin for 9 weeks. The digestibility of most macronutrients remained similar among the groups; however, fibre digestibility was improved (P = 0·034) in dogs receiving cPRO...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29152074/vanillic-acid-attenuates-testosterone-induced-benign-prostatic-hyperplasia-in-rats-and-inhibits-proliferation-of-prostatic-epithelial-cells
#6
Yunu Jung, Jinbong Park, Hye-Lin Kim, Dong-Hyun Youn, JongWook Kang, Seona Lim, Mi-Young Jeong, Gautam Sethi, Sung-Joo Park, Kwang Seok Ahn, Jae-Young Um
Benign prostatic hyperplasia (BPH) is a common disease in the male population, especially in elderly men. Vanillic acid (VA), a dihydroxybenzoic derivative used as a flavoring agent, is reported to have an anti-inflammatory effect. However, there are no reports of its effects on BPH to date. BPH was induced with a pre-4-week treatment of daily subcutaneous injections of testosterone propionate (TP), and the normal control group received injections of ethanol with corn oil instead. Six weeks of further injections were done with (a) ethanol with corn oil, (b) TP only, (c) TP + finasteride, and (d) TP + VA...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151650/molecular-modeling-of-cloned-bacillus-subtilis-keratinase-and-its-insinuation-in-psoriasis-treatment-using-docking-studies
#7
Sonali Gupta, Parul Tewatia, Jyoti Misri, Rajni Singh
Present study demonstrated the expression of cloned Bacillus subtilis RSE163 keratinase gene and in silico binding affinities of deduced protein with psoriasis topical drugs for systemic absorption and permeation through skin. The ker gene expressed in E. coli showed significantly higher keratinase activity 450 ± 10.43 U representing 1342 bp nucleotides encoding 447 amino acids with molecular weight of 46 kDa. The modeled structure was validated using ramachandran's plot showing 305 residues (84.3%) in most favoured region...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29150154/cutaneous-squamous-cell-carcinomas-scc-associated-with-cosmetic-skin-whitening-8-cases-reported-in-senegal
#8
F Ly, P Diousse, C Ndiaye, A Déme, B A Diatta, M T Ndiaye, M Diallo, A Diop, A D Kebe, F Fall, A Kane
BACKGROUND: The cosmetic use of bleaching products is common among women from sub-Saharan Africa. The most frequently used products are highly potent corticosteroids (clobetasol propionate) and hydroquinone. Herein, we report 8 cases of SCC in women using skin bleaching products for cosmetic purposes. Our aim is to describe the epidemiological, clinical and pathological aspects of the carcinomas observed during the course of skin lightening. METHODS: We conducted a descriptive multicentre study from August 2005 to January 2016 in three dermatology units in Senegal...
November 14, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29149674/the-impact-of-operational-strategies-on-the-performance-of-a-photo-ebpr-system
#9
V C F Carvalho, E B Freitas, P J Silva, J C Fradinho, M A M Reis, A Oehmen
A novel Phototrophic - Enhanced Biological Phosphorus Removal (Photo-EBPR) system, consisting of a consortium of photosynthetic organisms and polyphosphate accumulating organisms (PAOs), was studied in this work. A sequencing batch reactor was fed with a mixture of acetate and propionate (75%-25%) and subjected to dark/light cycles in order to select a photo-EBPR system containing PAOs and photosynthetic organisms, the latter likely providers of oxygen to the system. The results from the selection period (stage 1) showed that the photo-EBPR culture was capable of performing P release in the dark and P uptake in the presence of light, under limited oxygen concentrations...
November 4, 2017: Water Research
https://www.readbyqxmd.com/read/29148233/pd-catalyzed-%C3%AE-c-sp3-h-arylation-of-propionic-acid-and-related-aliphatic-acids
#10
Kiron Kumar Ghosh, Manuel van Gemmeren
A generally applicable Pd-catalyzed protocol for the β- C(sp3)-H arylation of propionic acid and related α-branched aliphatic acids is reported. Enabled by the use of N-acetyl-β-alanine as ligand our protocol delivers a broad range of arylation products. Notably, the highly challenging propionic acid, which lacks any acceleration through the Thorpe-Ingold effect, can be employed as substrate with synthetically useful yields. Furthermore, the scalability and synthetic applicability of the protocol are demonstrated...
November 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29145506/the-prpf-protein-of-shewanella-oneidensis-mr-1-catalyzes-the-isomerization-of-2-methyl-cis-aconitate-during-the-catabolism-of-propionate-via-the-acnd-dependent-2-methylcitric-acid-cycle
#11
Christopher J Rocco, Karl M Wetterhorn, Graeme S Garvey, Ivan Rayment, Jorge C Escalante-Semerena
The 2-methylcitric acid cycle (2-MCC) is a common route of propionate catabolism in microorganisms. In Salmonella enterica, the prpBCDE operon encodes most of the 2-MCC enzymes. In other organisms, e.g., Shewanella oneidensis MR-1, two genes, acnD and prpF replace prpD, which encodes 2-methylcitrate dehydratase. We showed that together, S. oneidensis AcnD and PrpF (SoAcnD, SoPrpF) compensated for the absence of PrpD in a S. enterica prpD strain. We also showed that SoAcnD had 2-methylcitrate dehydratase activity and that PrpF has aconitate isomerase activity...
2017: PloS One
https://www.readbyqxmd.com/read/29145169/a-zinc-schiff-base-complex-inhibits-cancer-progression-both-in-vivo-and-in-vitro-by-inducing-apoptosis
#12
Arpita Banerjee, Kaushik Banerjee, Abhinaba Sinha, Satyajit Das, Saikat Majumder, Subrata Majumdar, Soumitra Kumar Choudhuri
Cancer chemotherapy suffers from selectivity and undesired toxicity of the drugs. Since zinc is a biocompatible tracer element and cysteine derivatives are used in cancer chemoprevention, we intend to develop a complex of zinc and cysteine-derivatives as potent, non-toxic anticancer agents. Herein, we synthesized and characterized cysteine based ligand, 2-[(2-Hydroxy-3-methoxy-benzylidene)-amino]-3-mercapto-propionic acid and its Zn-complex, which are found to be non-toxic towards normal human PBMC. Data also revealed that only Zn-complex exhibited remarkable apoptosis in drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cancer cells as assessed by MTT, Cell cycle and AnnexinV binding assay...
November 6, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29143575/determination-of-illegal-adulteration-of-dietary-supplements-with-synthetic-hair-growth-compounds-by-uplc-and-lc-q-tof-ms
#13
Ji Hyun Lee, Gihaeng Kang, Han Na Park, Jihee Kim, Nam Sook Kim, Seongsoo Park, Sung-Kwan Park, Sun Young Baek, Hoil Kang
In this study, we developed a UPLC-PDA and LC-Q-TOF/MS method to identify and measure the following prohibited substances that may be found in dietary supplements: triaminodil, minoxidil, bimatoprost, alimemazine, diphenylcyclopropenone, α-tradiol, finasteride, methyltestosterone, spironolatone, flutamide, cyproterone, dutasteride, and testosterone 17-propionate.The method was validated according to International Conference on Harmonization guidelines in terms of specificity, linearity, accuracy, precision, LOD, LOQ, recovery, and stability...
November 16, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29142826/microbial-synthesis-of-a-branched-chain-ester-platform-from-organic-waste-carboxylates
#14
Donovan S Layton, Cong T Trinh
Processing of lignocellulosic biomass or organic wastes produces a plethora of chemicals such as short, linear carboxylic acids, known as carboxylates, derived from anaerobic digestion. While these carboxylates have low values and are inhibitory to microbes during fermentation, they can be biologically upgraded to high-value products. In this study, we expanded our general framework for biological upgrading of carboxylates to branched-chain esters by using three highly active alcohol acyltransferases (AATs) for alcohol and acyl CoA condensation and modulating the alcohol moiety from ethanol to isobutanol in the modular chassis cell...
December 2016: Metabolic Engineering Communications
https://www.readbyqxmd.com/read/29138672/testosterone-upregulates-the-expression-of-mitochondrial-nd1-and-nd4-and-alleviates-the-oxidative-damage-to-the-nigrostriatal-dopaminergic-system-in-orchiectomized-rats
#15
Wensheng Yan, Yunxiao Kang, Xiaoming Ji, Shuangcheng Li, Yingkun Li, Guoliang Zhang, Huixian Cui, Geming Shi
Testosterone deficiency, as a potential risk factor for aging and aging-related neurodegenerative disorders, might induce mitochondrial dysfunction and facilitate the declines of the nigrostriatal dopaminergic system by exacerbating the mitochondrial defects and increasing the oxidative damage. Thus, how testosterone levels influence the mitochondrial function in the substantia nigra was investigated in the study. The present studies showed that testosterone deficiency impaired the mitochondrial function in the substantia nigra and induced the oxidative damage to the substantia nigra as well as the deficits in the nigrostriatal dopaminergic system...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29137145/dietary-pea-fiber-supplementation-improves-glycemia-and-induces-changes-in-the-composition-of-gut-microbiota-serum-short-chain-fatty-acid-profile-and-expression-of-mucins-in-glucose-intolerant-rats
#16
Zohre Hashemi, Janelle Fouhse, Hyun Seun Im, Catherine B Chan, Benjamin P Willing
Several studies have demonstrated the beneficial impact of dried peas and their components on glucose tolerance; however, the role of gut microbiota as a potential mediator is not fully examined. In this study, we investigated the effect of dietary supplementation with raw and cooked pea seed coats (PSC) on glucose tolerance, microbial composition of the gut, select markers of intestinal barrier function, and short chain fatty acid profile in glucose intolerant rats. Male Sprague Dawley rats were fed high fat diet (HFD) for six weeks to induce glucose intolerance, followed by four weeks of feeding PSC-supplemented diets...
November 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29136932/cell-immobilization-on-3d-printed-matrices-a-model-study-on-propionic-acid-fermentation
#17
Fabricio Dos Santos Belgrano, Olaf Diegel, Nei Pereira, Rajni Hatti-Kaul
This study uses three-dimensional (3D) printing technology as a tool for designing carriers for immobilization of microbial cells for bioprocesses. Production of propionic acid from glucose by immobilized Propionibacterium sp. cells was studied as a model system. For cell adsorption, the 3D-printed nylon beads were added to the culture medium during 3 rounds of cell cultivation. Cell adsorption and fermentation kinetics were similar irrespective of the bead size and lattice structure. The cells bound to 15 mm beads exhibited reduced fermentation time as compared to free cell fermentations; maximum productivity and propionic acid titer of 0...
November 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29136864/suspect-screening-of-halogenated-carboxylic-acids-in-drinking-water-using-ion-exchange-chromatography-high-resolution-orbitrap-mass-spectrometry-ic-hrms
#18
Matteo D Gallidabino, Laurence Hamdan, Bronagh Murphy, Leon P Barron
Retrospective in silico screening of analytical data for the identification of new or emerging disinfection by-products in drinking waters could be useful to assess quality and potential hazards, as well as help implement mitigation procedures more rapidly. Herein, the first study coupling ion exchange chromatography (IC) with high resolution mass spectrometry (HRMS) for the determination of halogenated carboxylic acid disinfectant by-products is reported. Separation was achieved using a Metrohm A Supp 5 column and a Na2CO3/NaHCO3 gradient eluent from 1/0...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136806/multivariate-analysis-of-organic-acids-in-fermented-food-from-reversed-phase-high-performance-liquid-chromatography-data
#19
Pablo Mortera, Federico A Zuljan, Christian Magni, Santiago A Bortolato, Sergio H Alarcón
Multivariate calibration coupled to RP-HPLC with diode array detection (HPLC-DAD) was applied to the identification and the quantitative evaluation of the short chain organic acids (malic, oxalic, formic, lactic, acetic, citric, pyruvic, succinic, tartaric, propionic and α-cetoglutaric) in fermented food. The goal of the present study was to get the successful resolution of a system in the combined occurrence of strongly coeluting peaks, of distortions in the time sensors among chromatograms, and of the presence of unexpected compounds not included in the calibration step...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136237/evaluation-of-the-addition-of-organic-acids-in-the-feed-and-or-water-for-broilers-and-the-subsequent-recovery-of-salmonella-typhimurium-from-litter-and-ceca
#20
D V Bourassa, K M Wilson, C R Ritz, B K Kiepper, R J Buhr
Three separate broiler Salmonella Typhimurium challenge experiments were conducted evaluating efficacy of formic and propionic acid feed supplements to suppress environmental and cecal Salmonella Typhimurium prevalence. In experiment 1, broilers were provided feed with 1 kg/ton formic acid or 5 kg/ton propionic acid feed additives or a basal control diet. At the day of placement, half of the pens were inoculated with seeder chicks orally challenged with a marker strain of Salmonella Typhimurium and to yield challenged and adjacent nonchallenged pens...
November 9, 2017: Poultry Science
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