Joo-Hee Choi, Ah-Ra Jang, Dong-Il Kim, Min-Jung Park, Seul-Ki Lim, Myung-Sun Kim, Jong-Hwan Park
Protein arginine methylation is a novel form of posttranslational modification mediated by protein arginine methyltransferase (PRMTs). PRMT1, a major isoform of the PRMT family, is responsible for various biological functions, including cellular differentiation. Although the important function that PRMT1 plays in various tissues is being increasingly recognized, its role in receptor activation of NF-κB ligand (RANKL)-induced osteoclastogenesis or osteoporosis has not yet been described. Here, we show that PRMT1 is essential for RANKL-induced osteoclastogenesis in vitro and for bone loss in vivo...
August 28, 2018: Experimental & Molecular Medicine