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https://www.readbyqxmd.com/read/23159951/glucagon-like-peptide-1-receptor-agonist-inhibits-asymmetric-dimethylarginine-generation-in-the-kidney-of-streptozotocin-induced-diabetic-rats-by-blocking-advanced-glycation-end-product-induced-protein-arginine-methyltranferase-1-expression
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Ayako Ojima, Yuji Ishibashi, Takanori Matsui, Sayaka Maeda, Yuri Nishino, Masayoshi Takeuchi, Kei Fukami, Sho-ichi Yamagishi
Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, contributes to diabetic nephropathy. We have found that glucagon-like peptide-1 (GLP-1) inhibits the AGE-induced inflammatory reactions in endothelial cells. However, effects of GLP-1 on the AGE-RAGE-ADMA axis are unknown. This study examined the effects of GLP-1 on reactive oxygen species (ROS) generation, gene expression of protein arginine methyltransfetase-1 (PRMT-1), an enzyme that mainly generates ADMA, and ADMA levels in human proximal tubular cells...
January 2013: American Journal of Pathology
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