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https://www.readbyqxmd.com/read/27899532/long-term-management-for-ventilator-assisted-children-in-hong-kong-2-decades-experience
#1
Shuk-Kuen Chau, Ada Wing-Yan Yung, So-Lun Lee
BACKGROUND: The population of children receiving long-term mechanical ventilation is growing worldwide, but only limited data exist in Asian regions. The objective of the study was to review the management of these children in Hong Kong over the past 2 decades. METHODS: This was a retrospective cohort study. Hospital records from subjects receiving mechanical ventilation for >3 months were retrieved. Demographic characteristics and medical information of subjects (≤21 y old) under the care of the ventilator program at the Duchess of Kent Children's Hospital between 1997 and 2015 were reviewed...
November 29, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27899263/adalimumab-dose-escalation-is-effective-and-well-tolerated-in-crohn-s-disease-patients-with-secondary-loss-of-response-to-adalimumab
#2
Nicolas Duveau, Maria Nachury, Romain Gerard, Julien Branche, Vincent Maunoury, Medina Boualit, Pauline Wils, Pierre Desreumaux, Benjamin Pariente
BACKGROUND: Although adalimumab is effective in Crohn's disease, most patients experience a loss of response over time. The aim of the present study was to evaluate efficacy and safety of adalimumab dose escalation and identify predictors of a clinical response in Crohn's disease patients with a secondary loss of response. METHODS: We performed a retrospective and observational study including all Crohn's disease patients who underwent dose escalation of adalimumab after a secondary loss of response from 2007 to 2015...
November 14, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27882833/evaluation-of-real-world-experience-with-tofacitinib-compared-with-adalimumab-etanercept-and-abatacept-in-ra-patients-with-1-previous-biologic-dmard-data-from-a-u-s-administrative-claims-database
#3
James Harnett, Robert Gerber, David Gruben, Andrew S Koenig, Connie Chen
BACKGROUND: Real-world data comparing tofacitinib with biologic disease-modifying antirheumatic drugs (bDMARDs) are limited. OBJECTIVE: To compare characteristics, treatment patterns, and costs of patients with rheumatoid arthritis (RA) receiving tofacitinib versus the most common bDMARDs (adalimumab [ADA], etanercept [ETN], and abatacept [ABA]) following a single bDMARD in a U.S. administrative claims database. METHODS: This study was a retrospective cohort analysis of patients aged ≥ 18 years with an RA diagnosis (ICD-9-CM codes 714...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27879353/2016-health-care-education-presidential-address-if-dsme-were-a-pill-would-you-prescribe-it
#4
Margaret A Powers
This address was delivered by Margaret A. Powers, PhD, RD, CDE, President, Health Care & Education, of the American Diabetes Association (ADA), at the ADA's 76th Scientific Sessions in New Orleans, LA, on 11 June 2016. Dr. Powers conducts research and has a clinical practice as a registered dietitian and diabetes educator at the International Diabetes Center at Park Nicollet in Minneapolis. Her research focuses on improving diabetes outcomes including factors that affect the clinical, psychosocial, and behavioral aspects of diabetes...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27866643/evaluating-levels-of-dentist-participation-in-medicaid-a-complicated-endeavor
#5
Clayton J Warder, Burton L Edelstein
BACKGROUND: The availability of dentists to care for Medicaid beneficiaries is a longstanding concern of many families and those who serve them in the dental profession as well as policy makers. Yet, little information beyond the number of enrolled dentists has been reliably determined. The American Dental Association (ADA) Health Policy Institute has called for more nuanced measures that better reflect dentistry's contribution to the care of Medicaid beneficiaries. METHODS: The authors calculated percentages of general and pediatric dentists who enrolled in Medicaid, billed Medicaid, and treated Medicaid beneficiaries in each state for which data were available from the ADA's 2008 study, the Association of State and Territorial Dental Directors' 2013 report, and the 2013 federal Web site InsureKidsNow...
November 17, 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/27859570/diabetes-incidence-and-prevalence-in-hong-kong-china-during-2006-2014
#6
J Quan, T K Li, H Pang, C H Choi, S C Siu, S Y Tang, N M Wat, J Woo, J M Johnston, G M Leung
AIMS: To estimate recent secular changes in the incidence and prevalence of diabetes and pre-diabetes among Hong Kong Chinese adults, and thus show possible future trends for developing mainland China. METHODS: Based on a complete census of the public sector health records of 6.4 million people from 2006 to 2014, diabetes cases were ascertained using different methods including the World Health Organization (WHO) 2011 guidelines (HbA1c , fasting plasma glucose and glucose tolerance test), American Diabetes Association (ADA) 2015 guidelines (plus random plasma glucose), and additionally recorded diagnosis codes and medication dispensation...
November 12, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27832749/type-2-diabetes-compromises-the-value-of-non-invasively-measured-augmentation-index-in-predicting-the-severity-of-coronary-artery-disease-a-hospital-based-observational-study
#7
Sijing Wu, Yujie Zhou, Yueping Li, Yuyang Liu, Dongmei Shi, Xiaoli Liu, Wei Liu, Yi Yu, Shuo Jia
BACKGROUND: Central hemodynamic indices have been demonstrated to correlate with coronary artery disease (CAD). However, in the context of type 2 diabetes mellitus (DM), this correlation has not been fully illustrated. Therefore, this study was employed to investigate the impact of DM on the correlation between aortic augmentation index and the severity of coronary artery disease. METHODS: In this study, we analyzed 197 patients who underwent coronary angiography at Anzhen Hospital from September 2015 to January 2016...
November 10, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27761942/effects-of-advanced-carbohydrate-counting-guided-by-an-automated-bolus-calculator-in-type-1-diabetes-mellitus-stenoabc-a-12-month-randomized-clinical-trial
#8
E Hommel, S Schmidt, D Vistisen, K Neergaard, M Gribhild, T Almdal, K Nørgaard
AIMS: To test whether concomitant use of an automated bolus calculator for people with Type 1 diabetes carrying out advanced carbohydrate counting would induce further improvements in metabolic control. METHODS: We conducted a 12-month, randomized, parallel-group, open-label, single-centre, investigator-initiated clinical study. We enrolled advanced carbohydrate counting-naïve adults with Type 1 diabetes and HbA1c levels 64-100 mmol/mol (8.0-11.3%), who were receiving multiple daily insulin injection therapy...
October 20, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27753881/ish-ada-02-comparison-of-pulse-wave-velocity-and-pulse-pressure-amplification-in-the-association-with-target-organ-damages-in-the-community-based-elderly-the-northern-shanghai-study
#9
Bin Bai, Jin Xiong, Yuyan Lv, Shikai Yu, Jiadela Teliewubai, Chen Chi, Yiwu Zhou, Kai Wang, Le Wang, Yi Zhang, Yawei Xu
OBJECTIVE: To investigate the discrepancy between PWV and PPA in association with hypertensive TODs in the elderly population. DESIGN AND METHOD: From June 2014 to August 2015, a total of 1599 community-based elderly subjects (age > 65 years old) located in the northern Shanghai were recruited. The carotid-femoral pulse wave velocity (cfPWV), peripheral blood pressure (BP), central BP and other TODs indicators including the ratio of the early ventricular filling velocity (E) to the peak velocity of tissue Doppler velocity of septal mitral annulus (E/Ea), left ventricular mass index (LVMI), carotid intima-medium thickness (IMT), estimated glomerular filtration rate (eGFR), urinary albumin-creatinine rate (ACR) were assessed on each participant...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27709443/safety-and-efficacy-of-etanercept-and-adalimumab-in-children-aged-2-to-4%C3%A2-years-with-juvenile-idiopathic-arthritis
#10
D Windschall, G Horneff
The TNF inhibitors etanercept (ETA) and adalimumab (ADA) are approved for treating patients older than 2 years with polyarticular juvenile idiopathic arthritis (JIA). Because long-term experience of treating children younger than 4 years is limited, we evaluated the efficacy and safety of ETA or ADA in patients aged 2-4 years. This prospective, long-term, observational registry study documented baseline demographics, clinical characteristics, disease activity parameters, and safety of patients treated with ETA or ADA...
October 5, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27688936/review-of-clinical-studies-of-perampanel-in-adolescent-patients
#11
REVIEW
Heung Dong Kim, Ching-Shiang Chi, Tayard Desudchit, Marina Nikanorova, Anannit Visudtibhan, Charcrin Nabangchang, Derrick W S Chan, Choong Yi Fong, Kai-Ping Chang, Shang-Yeong Kwan, Fe De Los Reyes, Chao-Ching Huang, Surachai Likasitwattanakul, Wang-Tso Lee, Ada Yung, Amitabh Dash
AIM: To assess the clinical trial and real-world data for adjunctive perampanel in adolescents and develop consensus recommendations to guide the use of perampanel in this population in clinical practice. METHODS: In May 2015, 15 epilepsy experts attended a Consensus Development Meeting to assess the clinical trial data for perampanel, specific to the adolescent age group (12-17 years) and develop consensus treatment recommendations. RESULTS AND DISCUSSION: Analysis of the adolescent subgroup data of three pivotal placebo-controlled, double-blind, phase 3 trials investigating perampanel in patients with ongoing focal epileptic seizures despite receiving one to three antiepileptic drugs found that perampanel 4-12 mg was superior to placebo...
September 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27666569/adalimumab-or-infliximab-as-monotherapy-or-in-combination-with-an-immunomodulator-in-the-treatment-of-crohn-s-disease
#12
J Cosnes, H Sokol, A Bourrier, I Nion-Larmurier, A Wisniewski, C Landman, P Marteau, L Beaugerie, K Perez, P Seksik
BACKGROUND: The comparative efficacy of adalimumab (ADA) and infliximab (IFX) in Crohn's disease, and the benefit of initial combotherapy with an immunomodulator, are debated. AIM: To assess the best anti-TNF treatment regimens in Crohn's disease. METHODS: We included 906 biologic-naïve Crohn's disease patients [median age, 31 years (24-41)] and performed a retrospective analysis of 1284 therapeutic exposures to ADA (n = 521) or IFX (n = 763) between 2006 and 2015...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27664107/a-retrospective-claims-database-study-on-drug-utilization-in-japanese-patients-with-crohn-s-disease-treated-with-adalimumab-or-infliximab
#13
Kaoru Yokoyama, Kiyotaka Yamazaki, Miiko Katafuchi, Sameh Ferchichi
INTRODUCTION: Crohn's disease (CD) is a chronic and progressive disease in which the long-term management is important. This study sought to assess treatment persistence and dose escalation in the maintenance phase with adalimumab (ADA) or infliximab (IFX) in a Japanese real-world setting. METHODS: A retrospective analysis was conducted using the Japan Medical Data Center database. CD patients with either ADA or IFX prescriptions between January 2012 and February 2015 were included...
November 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27643174/ish-ada-02-comparison-of-pulse-wave-velocity-and-pulse-pressure-amplification-in-the-association-with-target-organ-damages-in-the-community-based-elderly-the-northern-shanghai-study
#14
Bin Bai, Jin Xiong, Yuyan Lv, Shikai Yu, Jiadela Teliewubai, Chen Chi, Yiwu Zhou, Kai Wang, Le Wang, Yi Zhang, Yawei Xu
OBJECTIVE: To investigate the discrepancy between PWV and PPA in association with hypertensive TODs in the elderly population. DESIGN AND METHOD: From June 2014 to August 2015, a total of 1599 community-based elderly subjects (age > 65 years old) located in the northern Shanghai were recruited. The carotid-femoral pulse wave velocity (cfPWV), peripheral blood pressure (BP), central BP and other TODs indicators including the ratio of the early ventricular filling velocity (E) to the peak velocity of tissue Doppler velocity of septal mitral annulus (E/Ea), left ventricular mass index (LVMI), carotid intima-medium thickness (IMT), estimated glomerular filtration rate (eGFR), urinary albumin-creatinine rate (ACR) were assessed on each participant...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27575553/standing-on-the-shoulders-of-stem-cell-gene-therapists-history-hyperbole-and-hope-for-the-future
#15
Jason Gardner
A new type of medicine was approved in Europe at the end of May that culminated from the successful convergence of two fields of science: stem cell transplantation and gene therapy. Strimvelis, a patient-specific gene-modified stem cell medicine for ADA-SCID (a fatal immunometabolic disorder similar to the bubble-boy disease), was developed by scientists at the San Raffaele Telethon Institute for Gene Therapy (TIGET) in Milan, then later partnered with GSK. The journey took over 25 years of dedicated work from many groups and involved a pivotal trial with 12 children and their brave families...
August 30, 2016: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/27573380/hypofractionation-with-no-boost-after-breast-conservation-in-early-stage-breast-cancer-patients
#16
Francesca Arcadipane, Pierfrancesco Franco, Chiara De Colle, Nadia Rondi, Jacopo Di Muzio, Emanuela Pelle, Stefania Martini, Ada Ala, Mario Airoldi, Michela Donadio, Corrado De Sanctis, Isabella Castellano, Riccardo Ragona, Umberto Ricardi
The aim of this study was to evaluate local control, survival and toxicity profile of a consecutive cohort of early-stage breast cancer (EBC) patients treated with adjuvant hypofractionated radiotherapy (HF) with no boost delivered to the lumpectomy cavity, after breast-conserving surgery (BCS). Between 2005 and 2015, a total of 493 women affected with EBC were treated with HF (46 Gy/20 fractions or 40.05 Gy/15 fractions) to the whole breast without boost to tumor bed, because of age and/or favorable tumor characteristics...
October 2016: Medical Oncology
https://www.readbyqxmd.com/read/27568359/use-of-standardised-patients-to-assess-antibiotic-dispensing-for-tuberculosis-by-pharmacies-in-urban-india-a-cross-sectional-study
#17
Srinath Satyanarayana, Ada Kwan, Benjamin Daniels, Ramnath Subbaraman, Andrew McDowell, Sofi Bergkvist, Ranendra K Das, Veena Das, Jishnu Das, Madhukar Pai
BACKGROUND: India's total antibiotic use is the highest of any country. Patients often receive prescription-only drugs directly from pharmacies. Here we aimed to assess the medical advice and drug dispensing practices of pharmacies for standardised patients with presumed and confirmed tuberculosis in India. METHODS: In this cross-sectional study in the three Indian cities Delhi, Mumbai, and Patna, we developed two standardised patient cases: first, a patient presenting with 2-3 weeks of pulmonary tuberculosis symptoms (Case 1); and second, a patient with microbiologically confirmed pulmonary tuberculosis (Case 2)...
November 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27444173/biosimilar-erythropoiesis-stimulating-agents-and-the-risk-of-developing-anti-drug-antibodies-a-systematic-review
#18
REVIEW
Marianne Heibert Arnlind, Linda Fryklund, Sigurd Vitols, Göran Bertilsson
PURPOSE: We systematically reviewed published observational studies and randomized controlled trials (RCT) reports of clinical trials on erythropoiesis-stimulating agents (ESA's). Only studies evaluating the risk of developing anti-drug antibodies (ADA) of both original and biosimilar drugs were chosen. METHODS: Databases including PubMed, EMBASE and Cochrane Library were searched up to 17 March 2015. Two reviewers independently assessed the relevant studies for risk of bias...
October 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27432171/adalimumab-for-the-treatment-of-refractory-noninfectious-paediatric-uveitis
#19
Alicia Muñoz-Gallego, Estefanía Barral, Eugenia Enríquez, Pilar Tejada, Ana Barceló, Jaime de Inocencio
To report the experience of our center with the use of adalimumab (ADA) for the treatment of severe refractory noninfectious paediatric uveitis. The study is a retrospective case series of all paediatric patients with refractory uveitis who were treated with ADA at the Paediatric Uveitis Unit of our center from 2008 to 2015. We present 12 patients (6 Juvenile idiopathic arthritis-associated uveitis, 4 idiopathic panuveitis, 1 early-onset sarcoidosis-associated panuveitis, and 1 intermediate uveitis), with uveitis in 19/24 eyes...
July 18, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27401009/development-and-validation-of-the-comples-score-for-differentiating-between-tuberculous-effusions-with-low-pleural-ph-or-glucose-and-complicated-parapneumonic-effusions
#20
Luis Corral-Gudino, Alberto García-Zamalloa, Cristina Prada-González, Silvia Bielsa, Duckens Alexis, Jorge Taboada-Gómez, Pilar R Dos-Santos-Gallego, María A Alonso-Fernández, Jose M Porcel
BACKGROUND: The frequency of "complicated" pleural effusions (CPE) (i.e., pleural fluid pH ≤ 7.2 and/or glucose ≤60 mg/dL) of tuberculous origin (CTPE) is not well reported. This study aims to quantify their prevalence, and develop a score to differentiate CTPE from complicated parapneumonic effusions (CPPE). METHODS: Retrospective analysis of databases from three Spanish hospitals which included patients with CTPE and CPPE. Forty percent of the study population served to generate a scoring system (COMPLES, COMplicated PLeural Effusion Score) that was further validated in the remaining 60 %...
October 2016: Lung
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