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ADA 2016

Y Gallais, N Szely, F-X Legrand, A Leroy, M Pallardy, I Turbica
Patients treated with therapeutic biological products (BP) frequently develop anti-drug antibodies (ADA) with potential neutralizing capacities leading to loss of clinical response, or serious side effects. BP aggregates have been suggested to promote immunogenicity thus enhancing ADA production. Dendritic cells (DC) are key effectors in T-cell and B-cell fates and the subsequent generation of immunogenicity. The objective of this work was to determine if BP aggregates can participate to DC maturation and T-cell activation...
October 7, 2016: Immunology and Cell Biology
Desmond Schatz
This address was delivered by Desmond Schatz, MD, President, Medicine & Science, of the American Diabetes Association (ADA), at the Association's 76th Scientific Sessions in New Orleans, LA, on 12 June 2016. Dr. Schatz is Professor and Associate Chairman of Pediatrics, Medical Director of the University of Florida Diabetes Institute, and Director of the Clinical Research Center at the University of Florida, Gainesville, FL. A physician-scientist, he has been involved in type 1 diabetes research since the mid-1980s and has published over 300 articles and book chapters...
October 2016: Diabetes Care
Emma J Schneider, Natasha A Lannin, Louise Ada, Julia Schmidt
QUESTIONS: In people receiving rehabilitation aimed at reducing activity limitations of the lower and/or upper limb after stroke, does adding extra rehabilitation (of the same content as the usual rehabilitation) improve activity? What is the amount of extra rehabilitation that needs to be provided to achieve a beneficial effect? DESIGN: Systematic review with meta-analysis of randomised trials. PARTICIPANTS: Adults aged 18 years or older that had a diagnosis of stroke...
October 2016: Journal of Physiotherapy
Ada H Zohar, Lilac Lev Ari, Rachel Bachner-Melman
This study focused on the quality of the relationship between women with a lifetime anorexia nervosa (AN) diagnosis and their sisters, in the context of family functioning. Participants were 112 sister pairs including a woman with a lifetime diagnosis of AN, and 356 sister pairs with no history of an eating disorder. Participants completed the Sibling Relationship Questionnaire, Family Environment Scale and Eating Attitudes Test-26. We hypothesised that sister relationships would be less favourably assessed by women with an AN diagnosis than by their sisters, and less favourably assessed overall in the AN sister pairs than in the healthy sib-pair controls...
August 8, 2016: European Eating Disorders Review: the Journal of the Eating Disorders Association
Manuela Mihailiasa, Fabrizio Caldera, Jiemeng Li, Roberta Peila, Ada Ferri, Francesco Trotta
No abstract text is available yet for this article.
October 20, 2016: Carbohydrate Polymers
S Lam
The 76th American Diabetes Association (ADA) Scientific Sessions took place in New Orleans, Louisiana, USA. The meeting brought together scientists and professionals from a wide range of disciplines in the field of diabetes and provided a platform for networking, allowing experts and researchers to share ideas and learn about the significant advances in diabetes research, treatment and care. Over the course of the 5 days, participants received exclusive access to more than 2,500 original research presentations...
June 2016: Drugs of Today
Michael D Fountain, Emmelien Aten, Megan T Cho, Jane Juusola, Magdalena A Walkiewicz, Joseph W Ray, Fan Xia, Yaping Yang, Brett H Graham, Carlos A Bacino, Lorraine Potocki, Arie van Haeringen, Claudia A L Ruivenkamp, Pedro Mancias, Hope Northrup, Mary K Kukolich, Marjan M Weiss, Conny M A van Ravenswaaij-Arts, Inge B Mathijssen, Sebastien Levesque, Naomi Meeks, Jill A Rosenfeld, Danielle Lemke, Ada Hamosh, Suzanne K Lewis, Simone Race, Laura L Stewart, Beverly Hay, Andrea M Lewis, Rita L Guerreiro, Jose T Bras, Marcia P Martins, Gerarda Derksen-Lubsen, Els Peeters, Connie Stumpel, Sander Stegmann, Levinus A Bok, Gijs W E Santen, Christian P Schaaf
PURPOSE: Truncating mutations in the maternally imprinted, paternally expressed gene MAGEL2, which is located in the Prader-Willi critical region 15q11-13, have recently been reported to cause Schaaf-Yang syndrome, a Prader-Willi-like disease that manifests as developmental delay/intellectual disability, hypotonia, feeding difficulties, and autism spectrum disorder. The causality of the reported variants in the context of the patients' phenotypes was questioned, as MAGEL2 whole-gene deletions seem to cause little or no clinical phenotype...
May 19, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Ayodele Jacob Akinyemi, Gustavo Roberto Thomé, Vera Maria Morsch, Nathieli B Bottari, Jucimara Baldissarelli, Lizielle Souza de Oliveira, Jeferson Ferraz Goularte, Adriane Belló-Klein, Ganiyu Oboh, Maria Rosa Chitolina Schetinger
Hypertension is associated with platelet alterations that could contribute to the development of cardiovascular complications. Several studies have reported antiplatelet aggregation properties of ginger (Zingiber officinale) and turmeric (Curcuma longa) with limited scientific basis. Hence, this study assessed the effect of dietary supplementation of these rhizomes on platelet ectonucleotidase and adenosine deaminase (ADA) activities in Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME) induced hypertensive rats...
July 2016: Phytotherapy Research: PTR
Lei Ye, Ada O Youk, Susan M Sereika, Stewart J Anderson, Lora E Burke
Parametric mixed-effects models are useful in longitudinal data analysis when the sampling frequencies of a response variable and the associated covariates are the same. We propose a three-step estimation procedure using local polynomial smoothing and demonstrate with data where the variables to be assessed are repeatedly sampled with different frequencies within the same time frame. We first insert pseudo data for the less frequently sampled variable based on the observed measurements to create a new dataset...
September 10, 2016: Statistics in Medicine
Karine Lanes da Silveira, Leonardo Lanes da Silveira, Maria Luiza Prates Thorstenberg, Fernanda Licker Cabral, Livia Gelain Castilhos, João Felipe Peres Rezer, Diego Fontana de Andrade, Ruy Carlos Ruver Beck, Heloísa Einloft Palma, Cinthia Melazzo de Andrade, Renata da Silva Pereira, Nara Maria Beck Martins, Claudia de Mello Bertonchel Dos Santos, Daniela Bitencourt Rosa Leal
UNLABELLED: The effect of vitamin D3 in oral solution (VD3 ) and vitamin D3 -loaded nanocapsules (NC-VD3 ) was analysed in animals with complete Freund's adjuvant (CFA) induced arthritis (AR). For this purpose, we evaluated scores for arthritis, thermal hyperalgesia and paw oedema, as well as histological analyses and measurements of the activity of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) and ecto-adenosine deaminase (E-ADA) enzymes in rat lymphocytes. Haematological and biochemical parameters were also determined...
June 2016: Cell Biochemistry and Function
Karen Laky, Ada M Kruisbeek
In vivo depletion of T lymphocytes is a means of studying the role of specific T cell populations during defined phases of in vivo immune responses. In this unit, a protocol is provided for injecting monoclonal antibodies (mAbs) into wild-type adult mice. Depletion of the appropriate subset of cells is verified by flow cytometry analysis of lymph node and spleen cell suspensions in pilot experiments. Once conditions have been established, depleted mice can be used to study the impact of T cell subsets on a variety of in vivo immune responses...
2016: Current Protocols in Immunology
T Roostaei, A Nazeri, D Felsky, P L De Jager, J A Schneider, B G Pollock, D A Bennett, A N Voineskos
The lack of strong association between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzheimer's disease (AD) field. Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia. We sought to identify the genetic modifiers of the relation between cortical beta-amyloid burden (measured using [(18)F]Florbetapir-PET) and cognitive dysfunction (measured using ADAS-cog) by conducting a genome-wide interaction study on baseline data from participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) phases GO/2 (n=678)...
March 29, 2016: Molecular Psychiatry
Angela Pipitone, Donna B Raval, Jessica Duis, Hilary Vernon, Regina Martin, Ada Hamosh, David Valle, Meral Gunay-Aygun
3-hydroxy-3-methylglutaric (HMG)-CoA lyase is required for ketogenesis and leucine degradation. Patients with HMG-CoA lyase deficiency typically present with hypoketotic hypoglycemia and metabolic acidosis, which can be fatal if untreated. The patient is a 28-year-old female with HMG-CoA lyase deficiency who presented at 4 weeks gestation for prenatal care. Protein intake as well as carnitine supplementation were gradually increased to support maternal and fetal demands up to 65 g per day for protein and 80 mg/kg/day for carnitine...
June 2016: American Journal of Medical Genetics. Part A
Thomas Van Stappen, Els Brouwers, Séverine Vermeire, Ann Gils
A meta-analysis revealed that up to 51% of patients treated with infliximab develop anti-drug Abs (ADA) which are associated with loss of response. Detection of ADA is strongly influenced by assay technique since drug-sensitive ADA assays are not able to detect ADA in the presence of drug and therefore underestimate ADA development. In addition, the lack of a calibrator antibody that can be used in a drug-sensitive and drug-tolerant assay hampers an adequate comparison among different assays. Here we present a sample pretreatment protocol to convert the bridging assay, originally developed as a drug-sensitive assay, into a drug-tolerant assay, allowing use of the same assay and calibrator antibody MA-IFX10F9...
March 16, 2016: Drug Testing and Analysis
Israel Contador, Bernardino Fernández-Calvo, Francisco Ramos, Javier Olazarán
OBJECTIVES: This research retrospectively analyzed the effect of education on cognitive interventions carried out in patients with mild Alzheimer's disease (AD). METHODS: The total sample consisted of 75 patients with mild AD receiving treatment with cholinesterase inhibitors. The participants were divided into two groups: cognitive intervention (IG; n=45) and waiting list (WLG; n=30). Patients in the IG received either the Big Brain Academy (n=15) or the Integrated Psychostimulation Program (n=30) during 12 weeks...
May 2016: Journal of the International Neuropsychological Society: JINS
James J Chamberlain, Andrew S Rhinehart, Charles F Shaefer, Annie Neuman
DESCRIPTION: The American Diabetes Association (ADA) published the 2016 Standards of Medical Care in Diabetes (Standards) to provide clinicians, patients, researchers, payers, and other interested parties with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care. METHODS: The ADA Professional Practice Committee performed a systematic search on MEDLINE to revise or clarify recommendations based on new evidence. The committee assigns the recommendations a rating of A, B, or C, depending on the quality of evidence...
April 19, 2016: Annals of Internal Medicine
Franck Housseau, Shaoguang Wu, Elizabeth C Wick, Hongni Fan, Xinqun Wu, Nicolas J Llosa, Kellie N Smith, Ada Tam, Sudipto Ganguly, Jane W Wanyiri, Thevambiga Iyadorai, Ausama A Malik, April C Roslani, Jamunarani S Vadivelu, Sara Van Meerbeke, David L Huso, Drew M Pardoll, Cynthia L Sears
IL17-producing Th17 cells, generated through a STAT3-dependent mechanism, have been shown to promote carcinogenesis in many systems, including microbe-driven colon cancer. Additional sources of IL17, such as γδ T cells, become available under inflammatory conditions, but their contributions to cancer development are unclear. In this study, we modeled Th17-driven colon tumorigenesis by colonizing Min(Ap) (c+/-) mice with the human gut bacterium, enterotoxigenic Bacteroides fragilis (ETBF), to investigate the link between inflammation and colorectal cancer...
April 15, 2016: Cancer Research
Titilope Oduyebo, Emily E Petersen, Sonja A Rasmussen, Paul S Mead, Dana Meaney-Delman, Christina M Renquist, Sascha R Ellington, Marc Fischer, J Erin Staples, Ann M Powers, Julie Villanueva, Romeo R Galang, Ada Dieke, Jorge L Muñoz, Margaret A Honein, Denise J Jamieson
CDC has updated its interim guidelines for U.S. health care providers caring for pregnant women during a Zika virus outbreak (1). Updated guidelines include a new recommendation to offer serologic testing to asymptomatic pregnant women (women who do not report clinical illness consistent with Zika virus disease) who have traveled to areas with ongoing Zika virus transmission. Testing can be offered 2-12 weeks after pregnant women return from travel. This update also expands guidance to women who reside in areas with ongoing Zika virus transmission, and includes recommendations for screening, testing, and management of pregnant women and recommendations for counseling women of reproductive age (15-44 years)...
February 12, 2016: MMWR. Morbidity and Mortality Weekly Report
Zsofia Lenkey, Akos Varga-Szemes, Tamas Simor, Rob J van der Geest, Robert Kirschner, Levente Toth, Tamas Bodnar, Brigitta C Brott, Ada Elgavish, Gabriel A Elgavish
PURPOSE: To test whether signal intensity percent infarct mapping (SI-PIM) accurately determines the size of myocardial infarct (MI) regardless of infarct age. MATERIALS AND METHODS: Forty-five swine with reperfused MI underwent 1.5T late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) after bolus injection of 0.2 mmol/kg Gd(DTPA) on days 2-62 following MI. Animals were classified into acute, healing, and healed groups by pathology. Infarct volume (IV) and infarct fraction (IF) were determined by two readers, using binary techniques (including 2-5 standard deviations [SD] above the remote, and full-width at half-maximum) and the SI-PIM method...
April 2016: Journal of Magnetic Resonance Imaging: JMRI
Sulen Sarioglu, Nilhan Akbulut, Selen Iplikci, Barbaros Aydin, Ersoy Dogan, Mehtat Unlu, Hulya Ellidokuz, Emel Ada, Fadime Akman, Ahmet Omer Ikiz
BACKGROUND: Tumor deposits, nodules in the peritumoral adipose tissue with no architectural residue of lymph node, have previously been described in colorectal adenocarcinomas. To date, however, there has been no examination of tumor deposits in head and neck squamous cell carcinoma (HNSCC). METHODS: Neck dissection specimens of 140 patients with HNSCC were reevaluated for tumor deposits. RESULTS: Tumor deposits were detected in 24 cases (17%)...
April 2016: Head & Neck
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