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https://www.readbyqxmd.com/read/29134286/proteomic-and-metabolomic-characterization-of-streptozotocin-induced-diabetic-nephropathy-in-timp3-deficient-mice
#1
Claudia Rossi, Valeria Marzano, Ada Consalvo, Mirco Zucchelli, Stefano Levi Mortera, Viviana Casagrande, Maria Mavilio, Paolo Sacchetta, Massimo Federici, Rossella Menghini, Andrea Urbani, Domenico Ciavardelli
AIMS: The tissue inhibitor of metalloproteinase TIMP3 is a stromal protein that restrains the activity of both protease and receptor in the extracellular matrix and has been found to be down-regulated in diabetic nephropathy (DN), the leading cause of end-stage renal disease in developed countries. METHODS: In order to gain deeper insights on the association of loss of TIMP3 and DN, we performed differential proteomic analysis of kidney and blood metabolic profiling of wild-type and Timp3-knockout mice before and after streptozotocin (STZ) treatment, widely used to induce insulin deficiency and hyperglycemia...
November 13, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29128918/moderate-physical-activity-reduces-10-year-diabetes-incidence-the-mediating-role-of-oxidative-stress-biomarkers
#2
Efi Koloverou, Konstantinos Tambalis, Demosthenes B Panagiotakos, Ekavi Georgousopoulou, Christina Chrysohoou, Ioannis Skoumas, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos
OBJECTIVES: To evaluate the effect of physical activity levels on 10-year diabetes incidence and investigate the potential mechanism. METHODS: In 2001-2002, a random sample of apparently healthy 3042 men and women (18-89 years) was selected to participate in the ATTICA study. Several socio-demographic, clinical and lifestyle characteristics were recorded. Physical activity level was recorded through a translated, validated, version of International Physical Activity Questionnaire (IPAQ); MET min/week was calculated and quartiles constructed...
November 11, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/29127747/-treatment-strategy-of-type-2%C3%A2-diabetes-used-in-czech-republic-after-metformin-therapy-failure
#3
Štěpán Svačina, Petra Ovesná, Matyáš Kuhn, Martina Nováčková
INTRODUCTION: Type 2 diabetes is an enormous medical problem caused by increasing prevalence of the disease and increasing prevalence of severe chronic complications of diabetes. New ADA/EASD guidelines and also Czech diabetes society guidelines enable effective individual approach to the patient. Goal of the therapy is optimal compensation of diabetes and prevention of acute and chronic complications of diabetes and decrease of mortality. Diabetes therapy is started by education in diet a regime combined with metformin...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29106816/insulin-glargine-300-u-ml-is-associated-with-less-weight-gain-while-maintaining-glycemic-control-and-low-risk-of-hypoglycemia-compared-with-insulin-glargine-100-u-ml-in-an-aging-population-with-type-2-diabetes
#4
Medha N Munshi, Jasvinder Gill, Jason Chao, Elena V Nikonova, Meenakshi Patel
OBJECTIVE: Assess efficacy, hypoglycemia and weight gain in patients with type 2 diabetes (T2D) treated with insulin glargine 300 U/mL (Gla-300) or 100 U/mL (Gla-100) across different age groups. METHODS: Pooled data were generated for patients randomized to Gla-300 or Gla-100 in the EDITION 2 (NCT01499095) and 3 (NCT01676220) studies. In four age groups (<55, ≥55 to <60, ≥60 to <65, ≥65 years), glycated hemoglobin A1C (A1C), percentage of patients reaching A1C <7...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29082640/achieving-ada-ispad-clinical-guideline-goals-is-associated-with-higher-insulin-sensitivity-and-cardiopulmonary-fitness-in-adolescents-with-type-1-diabetes-results-from-resistance-to-insulin-in-type-1-and-type-2-diabetes-resistant-and-effects-of-metformin-on
#5
Petter Bjornstad, Melanie Cree-Green, Amy Baumgartner, Gregory Coe, Yesenia Garcia Reyes, Michal Schäfer, Laura Pyle, Judith G Regensteiner, Jane Eb Reusch, Kristen J Nadeau
OBJECTIVE: Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be associated with better insulin sensitivity (IS) and cardiopulmonary fitness. METHODS: IS was quantified as glucose infusion rate (GIR) from a hyperinsulinemic-euglycemic clamp in youth with type 1 diabetes from the RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) (n = 86) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) (n = 41) cohorts (n = 127; age 15...
October 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29061312/an-additional-measurement-of-glycated-albumin-can-help-prevent-missed-diagnosis-of-diabetes-in-chinese-population
#6
Xingxing He, Lingwen Ying, Xiaojing Ma, Yun Shen, Hang Su, Jiahui Peng, Yufei Wang, Yuqian Bao, Jian Zhou, Weiping Jia
BACKGROUND: In subjects who present a first fasting plasma glucose (FPG1) ≥7.0mmol/l without classic symptoms of diabetes, diagnosis of diabetes will likely be missed without an additional oral glucose tolerance test (OGTT) in the Chinese population. Recent studies have shown that glycated albumin (GA) has advantages in reflecting postprandial hyperglycemia. Therefore, the present study evaluated whether additional measurement of GA could reduce the rate of missed diagnosis of diabetes...
October 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29054261/development-and-validation-of-various-phenotyping-algorithms-for-diabetes-mellitus-using-data-from-electronic-health-records
#7
Santiago Esteban, Manuel Rodríguez Tablado, Francisco E Peper, Yamila S Mahumud, Ricardo I Ricci, Karin S Kopitowski, Sergio A Terrasa
BACKGROUND AND OBJECTIVE: Recent progression towards precision medicine has encouraged the use of electronic health records (EHRs) as a source for large amounts of data, which is required for studying the effect of treatments or risk factors in more specific subpopulations. Phenotyping algorithms allow to automatically classify patients according to their particular electronic phenotype thus facilitating the setup of retrospective cohorts. Our objective is to compare the performance of different classification strategies (only using standardized problems, rule-based algorithms, statistical learning algorithms (six learners) and stacked generalization (five versions)), for the categorization of patients according to their diabetic status (diabetics, not diabetics and inconclusive; Diabetes of any type) using information extracted from EHRs...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29049850/-epigenetic-control-of-early-neurodegenerative-events-in-diabetic-retinopathy-by-the-histone-deacetylase-sirt6
#8
María A Zorrilla-Zubilete, Ada Yeste, Francisco J Quintana, Debra Toiber, Raul Mostoslavsky, Dafne M Silberman
Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus (DM) and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose-induced neuron and glial cell damage may occur shortly after the onset of diabetes which makes the disease hard to diagnose at early stages. SIRT6, a NAD-dependent sirtuin deacylase, modulates aging, energy metabolism and neurodegeneration...
October 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29042412/the-use-of-language-in-diabetes-care-and-education
#9
Jane K Dickinson, Susan J Guzman, Melinda D Maryniuk, Catherine A O'Brian, Jane K Kadohiro, Richard A Jackson, Nancy D'Hondt, Brenda Montgomery, Kelly L Close, Martha M Funnell
Language is powerful and can have a strong impact on perceptions as well as behavior. A task force, consisting of representatives from the American Association of Diabetes Educators (AADE) and the American Diabetes Association (ADA), convened to discuss language in diabetes care and education. This document represents the expert opinion of the task force. The literature supports the need for a language movement in diabetes care and education. There are effective ways of communicating about diabetes. This article provides recommendations for language used by health care professionals and others when discussing diabetes through spoken or written words-whether directed to people with diabetes, colleagues, or the general public, as well as research questions related to language and diabetes...
October 17, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29030996/re-examining-the-sensitivity-of-glycated-hemoglobin-to-screen-for-diabetes-mellitus
#10
Chun Wei Yap, Yee Gary Ang, Timothy Peng Lim Quek, Bee Hoon Heng, Daniel Ek Kwang Chew
BACKGROUND: Glycated hemoglobin (HbA1c) is one of the laboratory tests recommended by the ADA to screen for diabetes mellitus (DM). It is particularly suitable for population segments that cannot or are unwilling to fast for a screening test. Our study aims to determine if HbA1c would be a useful tool to screen for DM in a real world setting if ADA guidelines for repeat testing to confirm the diagnosis of DM are strictly adhered to. METHODS: We carried out a retrospective database study by extracting demographic and laboratory data from a chronic disease registry which collects data on adults from three tertiary hospitals and nine large primary care clinics in Singapore...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28985037/postoperative-sinonasal-morbidity-in-sellar-reconstruction-mucosal-autograft-versus-acellular-dermal-allograft
#11
Christopher R Roxbury, J Trent Magruder, Murugappan Ramanathan, Michael Lim, Gary L Gallia, Masaru Ishii, Douglas D Reh
BACKGROUND: Sellar pathology is increasingly addressed using the expanded endonasal approach (EEA). Although avascular graft reconstruction is an acceptable means to prevent cerebrospinal fluid leak, there are few data regarding sinonasal morbidity in these patients. In this study we compare rates of persistent postoperative crusting (PPC) and rhinosinusitis in patients undergoing sellar reconstruction with mucosal autografting and acellular dermal allografting (ADA). METHODS: Patients undergoing the EEA between 2008 and 2014 were categorized into 2 subgroups: mucosal reconstruction and ADA reconstruction...
October 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28959440/prevalence-and-phenotype-of-diabetes-and-prediabetes-using-fasting-glucose-vs-hba1c-in-a-caribbean-population
#12
Nigel Unwin, Christina Howitt, Angela Mc Rose, T Alafia Samuels, Anselm Jm Hennis, Ian R Hambleton
BACKGROUND: Both fasting plasma glucose (FPG) and HbA1c are recommended for the diagnosis of diabetes and prediabetes by the American Diabetes Association (ADA), and for diabetes by the World Health Organization. The ADA guidance is influential on clinical practice in many developing countries, including in the Caribbean and Latin America. We aimed to compare the prevalence and characteristics of individuals identified as having diabetes and prediabetes by FPG and HbA1c in a predominantly African ancestry Caribbean population...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28904260/impaired-%C3%AE-cell-function-and-decreased-insulin-sensitivity-in-subjects-with-normal-oral-glucose-tolerance-but-isolated-high-glycosylated-hemoglobin
#13
Qi Fu, Min Sun, Zhixiao Wang, Wei He, Yu Duan, Tao Yang
The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According to the ADA criteria of HbA1c cut-off point (5.7%), 3,517 subjects with NGT screened from a total of 7,855 middle-aged and elderly Chinese without known diabetes were divided into two groups, 1,877 subjects with HbA1c < 5...
September 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28898609/-diabetes-screening-in-patients-with-macrovascular-coronary-disease-are-the-new-european-guidelines-a-step-backwards
#14
Andreia Ribeiro, Sérgio Bravo Baptista, Mariana Faustino, Paulo Alves, Pedro Farto Abreu, Victor Machado Gil, Carlos Morais
BACKGROUND: The new European guidelines on diabetes mellitus and cardiovascular diseases propose that the FINnish Diabetes RIsk SCore should be used to evaluate the risk of diabetes mellitus and that diabetes mellitus screening in coronary artery disease patients should be based on fasting glucose and HbA1c. The 2 hour oral glucose tolerance test, recommended for all pts in the previous guidelines, is now only recommended for 'inconclusive' cases. We aimed to evaluate this new strategy...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28892816/treatment-of-type-1-diabetes-synopsis-of-the-2017-american-diabetes-association-standards-of-medical-care-in-diabetes
#15
James J Chamberlain, Rita Rastogi Kalyani, Sandra Leal, Andrew S Rhinehart, Jay H Shubrook, Neil Skolnik, William H Herman
Description: The American Diabetes Association (ADA) annually updates Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes. Methods: For the 2017 Standards of Care, the ADA Professional Practice Committee did MEDLINE searches from 1 January 2016 to November 2016 to add, clarify, or revise recommendations on the basis of new evidence...
October 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28878936/primary-care-physicians-utilization-of-type-2-diabetes-screening-guidelines-and-referrals-to-behavioral-interventions-a-survey-linked-retrospective-study
#16
Sandhya Mehta, Michelle Mocarski, Tami Wisniewski, Karin Gillespie, K M Venkat Narayan, Kathleen Lang
OBJECTIVE: To assess primary care physicians' (PCPs) knowledge of type 2 diabetes screening guidelines (American Diabetes Association (ADA) and 2008 US Preventive Services Task Force (USPSTF)), the alignment between their self-reported adherence and actual practice, and how often PCPs recommended diabetes prevention and self-management education programs (DPP/DSME). RESEARCH DESIGN AND METHODS: An online survey of PCPs to understand knowledge and adherence toward use of USPSTF/ADA guidelines and recommendation of DPP/DSME...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28837185/american-diabetes-association-77th-scientific-sessions-june-9-13-2017-san-diego-california-usa
#17
REVIEW
S Lam
The 77th American Diabetes Association (ADA) Sci-entific Sessions took place in San Diego, California. The meeting brought together scientists and professionals from a wide range of disciplines in the field of diabetes and provided a platform for networking, allowing experts and researchers to share ideas and learn about the significant advances in diabetes research, treatment and care. Over the course of the 5 days, participants received exclusive access to more than 2,500 original research presentations.
July 2017: Drugs of Today
https://www.readbyqxmd.com/read/28832911/different-strategies-for-diagnosing-gestational-diabetes-to-improve-maternal-and-infant-health
#18
REVIEW
Diane Farrar, Lelia Duley, Therese Dowswell, Debbie A Lawlor
BACKGROUND: Gestational diabetes mellitus (GDM) is carbohydrate intolerance resulting in hyperglycaemia with onset or first recognition during pregnancy. If untreated, perinatal morbidity and mortality may be increased. Accurate diagnosis allows appropriate treatment. Use of different tests and different criteria will influence which women are diagnosed with GDM. This is an update of a review published in 2011 and 2015. OBJECTIVES: To evaluate and compare different testing strategies for diagnosis of gestational diabetes mellitus to improve maternal and infant health while assessing their impact on healthcare service costs...
August 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28810850/variations-in-diabetes-remission-rates-after-bariatric-surgery-in-spanish-adults-according-to-the-use-of-different-diagnostic-criteria-for-diabetes
#19
María R Alhambra-Expósito, María J Molina-Puerta, María I Prior-Sánchez, Gregorio Manzano-García, Alfonso Calañas-Continente, María A Gálvez-Moreno
BACKGROUND: There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and from the American Diabetes Association (ADA). We also aim to analyse the degree of correlation between these sets of criteria. METHODS: Retrospective observational study in 127 patients undergoing bariatric surgery in a single centre (Hospital Universitario Reina Sofía, Córdoba, Spain) between January 2001 and December 2009...
August 15, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28783529/creed-study-hypoglycaemia-during-ramadan-in-individuals-with-type-2-diabetes-mellitus-from-three-continents
#20
Abdul Jabbar, Mohamed Hassanein, Salem A Beshyah, Kristina S Boye, Maria Yu, Steven M Babineaux
AIMS: To describe diabetes treatment and hypoglycaemia in individuals with Type 2 diabetes mellitus during Ramadan. METHODS: A multi-country, retrospective, observational study with data captured before, during, and after Ramadan. We report on a cohort of people (N=3250) with Type 2 diabetes mellitus in four culturally distinct regions: Asia, North Africa, Europe, and the Middle East. RESULTS: During Ramadan, the proportion of participants on oral anti-diabetic medication alone ranged from 68...
July 13, 2017: Diabetes Research and Clinical Practice
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