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https://www.readbyqxmd.com/read/28728559/effect-of-insulin-therapy-and-dietary-adjustments-on-safety-and-performance-during-simulated-soccer-tests-in-people-with-type-1-diabetes-study-protocol-for-a-randomized-controlled-trial
#1
Javier Calvo-Marín, Gabriel Torrealba-Acosta, Matthew Campbell, Jesse Gaboury, Ajmol Ali, Chih Hao Chen-Ku
BACKGROUND: Despite the reduction in glycemic derangement in patients with type 1 diabetes mellitus (T1D) through dietary and therapeutic adjustments implemented before, during and after continuous exercise, evidence for its effectiveness with intermittent forms of exercise, such as soccer, is still lacking. METHODS/DESIGN: We designed a study protocol for a randomized, crossover, double-blinded, controlled trial, for the evaluation of the effect that a strategy of dietary and therapeutic modifications may have on safety and performance of persons with T1D in soccer training sessions and cognitive testing...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28720876/not-performing-an-ogtt-results-in-significant-underdiagnosis-of-pre-diabetes-in-a-high-risk-adult-caucasian-population
#2
A S Meijnikman, C E M De Block, E Dirinck, A Verrijken, I Mertens, B Corthouts, L F Van Gaal
OBJECTIVE: Type 2 diabetes (T2DM) is known to be underdiagnosed. Tests for diagnosis include fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) and HbA1c. HbA1c can be tested in non-fasting conditions. Therefore, general practitioners almost no longer execute OGTT's. We evaluated the performance of OGTT versus HbA1c in a population consisting of overweight and obese subjects, which can be considered a 'high risk' population. RESEARCH DESIGN AND METHODS: 1241 overweight and obese subjects without a history of diabetes (Male/Female: 375/866, age 44±13 y, Body Mass Index 38...
July 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28718236/dose-comparison-and-side-effect-profile-of-metformin-extended-release-versus-metformin-immediate-release
#3
Maliha Hameed, Khurshid Khan, Sadia Salman, Nasir Mehmood
BACKGROUND: Diabetes Mellitus type 2 is very common worldwide, with majority of cases in Asia Pacific region. Metformin is the first line therapy, along with lifestyle modification for all type 2 diabetics as recommended by ADA. Metformin is available as conventional Metformin Immediate Release (MIR) and Metformin Extended Release (MXR). Metformin XR has better gastrointestinal tolerability and fewer side effects as compared to Metformin IR, with similar efficacy regarding anti-hyperglycaemic effects...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28713554/growth-hormone-receptor-antagonism-with-pegvisomant-in-insulin-resistant-non-diabetic-men-a-phase-ii-pilot-study
#4
Ada P Lee, Kathleen Mulligan, Morris Schambelan, Elizabeth J Murphy, Ethan J Weiss
Background: Growth hormone (GH) is known to affect insulin and glucose metabolism.  Blocking its effects in acromegalic patients improves diabetes and glucose metabolism. We aimed to determine the effect of pegvisomant, a GH receptor antagonist, on insulin resistance, endogenous glucose production (EGP) and lipolysis in insulin resistant non-diabetic men.  Methods: Four men between the ages of 18-62 with a BMI of 18-35kg/m (2), with insulin resistance as defined by a HOMA-IR > 2.77, were treated for four weeks with pegvisomant 20 mg daily...
2017: F1000Research
https://www.readbyqxmd.com/read/28693118/high-prevalence-of-organ-specific-autoantibodies-in-indian-type-1-diabetic-patients
#5
Shivaprasad Channabasappa, Anish Kolly, Annie Pulikkal, K M Prasanna Kumar
BACKGROUND: Type 1 diabetes (T1D) is frequently associated with other autoimmune conditions such as autoimmune thyroiditis, coeliac disease (CD) and Addison's disease. There are sparse data on the prevalence of antibodies against these conditions in Indian patients with T1D. This study aims to evaluate prevalence of these T1D associated autoantibodies in Indian patients. METHODS: Two hundred and fifty-eight patients with T1D were recruited from the Bangalore Diabetes Hospital and the Vydehi Institute of Medical Sciences and Research Centre (VIMS) for the study...
June 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28672742/high-prevalence-of-organ-specific-autoantibodies-in-indian-type-1-diabetic-patients
#6
Channabasappa Shivaprasad, Anish Kolly, Annie Pulikkal, K M Prasanna Kumar
BACKGROUND: Type 1 diabetes (T1D) is frequently associated with other autoimmune conditions such as autoimmune thyroiditis, coeliac disease (CD) and Addison's disease. There are sparse data on the prevalence of antibodies against these conditions in Indian patients with T1D. This study aims to evaluate prevalence of these T1D associated autoantibodies in Indian patients. METHODS: Two hundred and fifty-eight patients with T1D were recruited from the Bangalore Diabetes Hospital and the Vydehi Institute of Medical Sciences and Research Centre (VIMS) for the study...
July 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28662559/highlights-from-the-american-diabetes-association-s-2017-standards-of-medical-care-in-diabetes-for-osteopathic-physicians
#7
Eric L Johnson, Kim Pfotenhauer, Sarah Bradley, Rita R Kalyani, Jay H Shubrook
The American Diabetes Association (ADA) updates its Standards of Medical Care (SOMC) in Diabetes annually. These ADA standards make up a comprehensive document that serves as an excellent resource for clinical care. The current article comes from the ADA's Primary Care Advisory Group. This article highlights key aspects of the SOMC that are relevant to the day-to-day practice of osteopathic primary care physicians. It is not intended to replace the full SOMC but will refer to the master document for further explanation and evidence-based support...
July 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28656725/diabetes-news
#8
Payal H Marathe, Abigail E Dove, Kelly L Close
More than 16,000 people gathered in San Diego, CA, USA for the 77th annual Scientific Sessions of the American Diabetes Association (ADA). One of the most highly-anticipated sessions of the meeting was a presentation of integrated results from the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS and CANVAS-R) trials.(1) The program studied a total of 10,142 people across two trials.
June 28, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28618766/relationship-between-blood-glucose-levels-and-cardiovascular-risk-in-the-spanish-mediterranean-population
#9
Ángel Arturo López-González, Zoe Manzanero, María Teófila Vicente-Herrero, Sheila García-Agudo, María Gil-Llinás, Francisco Moreno-Morcillo
BACKGROUND/AIM: Diabetes is associated with an increased prevalence of cardiovascular disease. Impaired fasting glucose (IFG) is an intermediate clinical situation between normal glucose levels and type 2 diabetes. The aim of this study is to determine how fasting glucose concentrations affect different cardiovascular risk scales. MATERIALS AND METHODS: A descriptive study was conducted with 59,041 Mediterranean Spanish workers. IFG was determined using the American Diabetes Association (ADA) and the World Health Organization (WHO) criteria...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28584602/gestational-diabetes-mellitus-and-metabolic-disorder-among-the-different-phenotypes-of-polycystic-ovary-syndrome
#10
Mahnaz Ashrafi, Fatemeh Sheikhan, Arezoo Arabipoor, Nicole Rouhana, Roya Hosseini, Zahra Zolfaghari
OBJECTIVES: Polycystic ovary syndrome (PCOS) is a common endocrine disorder related to several metabolic consequences. However, there remains uncertainty regarding the metabolic features of various phenotypes. The aim of this study was to explore the relationship between the prevalence of gestational diabetes mellitus (GDM) and metabolic disorders among the four different phenotypes of PCOS. METHODS: A cross-sectional study was performed in Royan Institute including 208 pregnant women with a history of infertility and PCOS...
May 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28556176/lixisenatide-a-once-daily-prandial-glucagon-like-peptide-1-receptor-agonist-for-the-treatment-of-adults-with-type-2-diabetes
#11
Jennifer M Trujillo, Jennifer Goldman
Lixisenatide, a short-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA), has been available in Europe since 2013 and was recently approved in the United States for the treatment of type 2 diabetes (T2D) as an adjunct to diet and exercise. The objective of this systematic review is to describe the pharmacology, pharmacokinetics, safety, and efficacy of lixisenatide in patients with T2D. We conducted a search of the EMBASE database, limited to human studies with abstracts available in English. Published conference abstracts, limited to the American Diabetes Association (ADA) and the European Association for the Study of Diabetes meetings in 2015, as well as abstracts presented at the ADA meeting in 2016, were also screened...
May 27, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28496551/lack-of-association-between-toxoplasma-gondii-infection-and-diabetes-mellitus-a-matched-case-control-study-in-a-mexican-population
#12
Cosme Alvarado-Esquivel, Nayely Loera-Moncivais, Jesus Hernandez-Tinoco, Luis Francisco Sanchez-Anguiano, Guillermina Hernandez-Madrid, Elizabeth Rabago-Sanchez, Maria Magdalena Centeno-Tinoco, Ada A Sandoval-Carrillo, Jose M Salas-Pacheco, Oscar Vladimir Campos-Moreno, Elizabeth Irasema Antuna-Salcido
BACKGROUND: Very little is known about the association between infection with Toxoplasma gondii (T. gondii) and diabetes mellitus. We perform an age- and gender-matched case-control study to determine the association of T. gondii infection and diabetes mellitus. METHODS: Cases included 156 patients with diabetes mellitus and 156 controls without diabetes mellitus who attended in two public clinics in Durango City, Mexico. Sera of cases and controls were tested for the presence of anti-Toxoplasma IgG and IgM antibodies using commercially available enzyme-linked fluorescence assays (ELFA)...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28494594/caring-for-baby-s-teeth-starts-before-birth
#13
EDITORIAL
L Paglia
Care for a child's teeth and gums can start even before the baby is born. Pregnancy causes many hormonal changes, among these the rise of estrogen and progesterone increases the risk of developing oral health problems, like gingivitis and periodontitis.The presence of maternal periodontal diseases and active infections has been associated with adverse pregnancy outcomes, such as preterm birth, preeclampsia, gestational diabetes and foetal loss. Therefore, it is important to educate pregnant women about their oral hygiene and the importance of taking care of their newborn's oral health...
March 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28491872/incidence-and-contributing-factors-of-persistent-hyperglycemia-at-6-12-weeks-postpartum-in-iranian-women-with-gestational-diabetes-results-from-laga-cohort-study
#14
Sedigheh Nouhjah, Hajieh Shahbazian, Nahid Shahbazian, Alireza Jahanshahi, Shayesteh Jahanfar, Bahman Cheraghian
Background. A history of gestational diabetes is an important predictor of many metabolic disturbances later in life. Method. Life after gestational diabetes Ahvaz Study (LAGAs) is an ongoing population-based cohort study. Up to February 2016, 176 women with gestational diabetes underwent a 75 g oral glucose tolerance test (OGTT) at 6-12 weeks postpartum in Ahvaz (southwestern of Iran). Gestational diabetes was diagnosed according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria and the American Diabetes Association (ADA) criteria applied for diagnosis of postpartum prediabetes and diabetes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28459890/reducing-cv-risk-in-diabetes-an-ada-update
#15
Neil Skolnik, Florence M Jaffa, Rita R Kalyani, Eric Johnson, Jay H Shubrook
This Q&A highlights changes to the ADA's 2017 Standards of Care to help you fine-tune your approach to patients who have, or are at risk for, atherosclerotic CV disease.
May 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28459036/consensus-statement-on-dose-modifications-of-antidiabetic-agents-in-patients-with-hepatic-impairment
#16
REVIEW
Kalyan Kumar Gangopadhyay, Parminder Singh
Liver disease is an important cause of mortality in type 2 diabetes mellitus (T2DM). It is estimated that diabetes is the most common cause of liver disease in the United States. Virtually, entire spectrum of liver disease is seen in T2DM including abnormal liver enzymes, nonalcoholic fatty liver disease, cirrhosis, hepatocellular carcinoma, and acute liver failure. The treatment of diabetes mellitus (DM) in cirrhotic patients has particular challenges as follows: (1) about half the patients have malnutrition; (2) patients already have advanced liver disease when clinical DM is diagnosed; (3) most of the oral antidiabetic agents (ADAs) are metabolized in the liver; (4) patients often have episodes of hypoglycemia...
March 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28440751/validation-in-daily-clinical-situations-of-diascope-%C3%A2-a-software-developed-to-help-healthcare-professionals-individualize-antidiabetic-treatment-in-type-2-diabetes
#17
Francisco Javier Ampudia-Blasco, Francisco Javier García-Soidán, Manuela Rubio Sánchez, Tra-Mi Phan
INTRODUCTION: DiaScope(®) is a software to help in individualized prescription of antidiabetic treatment in type 2 diabetes. This study assessed its value and acceptability by different professionals. MATERIAL AND METHODS: DiaScope(®) was developed based on the ADA-EASD 2012 algorithm and on the recommendation of 12 international diabetes experts using the RAND/UCLA appropriateness method. The current study was performed at a single session. In the first phase, 5 clinical scenarios were evaluated, selecting the most appropriated therapeutic option among 4 possibilities (initial test)...
March 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28440515/-interpretation-of-the-international-joint-statement-on-metabolic-surgery-in-the-treatment-algorithm-for-type-2-diabetes
#18
Peng Zhang, Chengzhu Zheng
Along with the soaring prevalence of obesity and type 2 diabetes mellitus (T2DM) globally, metabolic and bariatric surgery (MBS) has been rapidly developing into a major surgical subspecialty. However, the indications, benefits and potential risks of MBS are still controversial so far. In September 2015, the 2nd Diabetes Surgery Summit (DSS-II() was successfully convened, and later on an international joint statement on metabolic surgery in the treatment algorithm for T2DM was released based upon the consensus reached in DSS-II(, aiming to serve as a new global clinical guideline...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28404514/postpartum-glucose-testing-related-factors-and-progression-to-abnormal-glucose-tolerance-in-a-rural-population-with-a-known-history-of-gestational-diabetes
#19
Haydeh Ghajari, Sedigheh Nouhjah, Hajieh Shahbazian, Rohollah Valizadeh, Noorollah Tahery
AIMS: Gestational diabetes is a strong risk factor for postpartum progression to glucose intolerance. The aims of the study were to determine rate of postpartum glucose testing , its related factors and rate of progression to glucose intolerance in women who underwent postpartum glucose testing after pregnancy that complicated by gestational diabetes. MATERIALS: this is a retrospective study and women with gestational diabetes who received prenatal care during 2005-2015 in 3 rural health centers of Khuramshahr (southwestern of Iran) were enrolled...
April 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28390333/utility-of-glycosylated-haemoglobin-in-diagnosing-diabetes-in-an-urban-sri-lankan-community
#20
C N Wijekoon, A Pathmeswaran, S Chackrewarthy, N Kato, A R Wickremasinghe
Introduction: American Diabetes Association (ADA) has officially endorsed glycosylated haemoglobin (HbA1c) as a diagnostic tool. The recommended cut-off for diagnosing diabetes is  6.5%. Objectives: To compare use of HbA1c and fasting plasma glucose (FPG) to diagnose diabetes in an urban Sri Lankan community. Methods: This cross-sectional study is based on baseline data from a prospective study on non-communicable diseases in randomly selected individuals aged 35-64 years in a selected community...
March 31, 2017: Ceylon Medical Journal
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