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diabetes ADA

Shenglan Qi, Huida Guan, Gang Deng, Tao Yang, Xuemei Cheng, Wei Liu, Ping Liu, Changhong Wang
Adenosine deaminase (ADA), which is a key enzyme in the metabolism of purine nucleosides, plays important roles in diverse disorders, such as tuberculosis, diabetes, liver disorders, and cancer. Determination of the activities of ADA and its isoenzymes in body fluids has received considerable attention in the diagnosis and treatment of relative diseases. Ultraviolet spectroscopy with adenosine (AD) as a substrate is a classical approach for screening potential ADA inhibitors by measuring the decrease in substrate (AD) at 265 nm or increase in the product (inosine) at 248 nm...
February 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
Mazhar Hussain, Muhammad Zafar Majeed Babar, Lubna Akhtar, Muhammad Shahbaz Hussain
Background and Objective: Increased neutrophil lymphocyte ratio (NLR) is a marker as well as predictor of various cardiac and non cardiac disorders. Our aim was to assess the relationship between NLR and different level of glycemic control in type 2 diabetic patients. Methods: An observational study was conducted at diabetic clinic of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from September 2016 to February 2017 in which 330 type 2 diabetic patients were randomly divided in to three groups based upon diabetes control according to ADA criteria...
November 2017: Pakistan Journal of Medical Sciences Quarterly
Monika Rani, Raghuvansh Kumar, Pawan Krishan
BACKGROUND: The increasing prevalence of type 2 diabetes mellitus (T2DM) and associated metabolic complications lead to the development of a syndrome known as "metabolic syndrome" (MetS), which is considered as one of the major risk factor not only for the development of cardiovascular diseases but also have a great impact on the quality of life. RESEARCH DESIGN AND METHODS: A descriptive, observational study involving the recruitment of patients with T2DM with and without MetS was carried out in outpatient department of endocrinology...
January 1, 2018: Journal of Pharmacy Practice
Aline da Silva Pereira, Lizielle Souza de Oliveira, Thauan Faccin Lopes, Jucimara Baldissarelli, Taís Vidal Palma, Mayara Sandrielly Pereira Soares, Luiza Spohr, Vera Maria Morsch, Cinthia Melazzo de Andrade, Maria Rosa Chitolina Schetinger, Roselia Maria Spanevello
Diabetes Mellitus (DM) is associated with an increased susceptibility to various infections, which might be attributed to changes in immune response owing to chronic hyperglycemia. Nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase, and adenosine deaminase (ADA) are important enzymes involved in the generation of anti-aggregant and anti-inflammatory microenvironments. The aim of this study was to evaluate the effect of gallic acid (GA) on the hematological parameters and ectonucleotidase activities in platelets, lymphocytes, and serum of diabetic rats...
February 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Davida F Kruger
EDITOR'S NOTE : This article is adapted from the address Ms. Kruger delivered as the recipient of the American Diabetes Association's Outstanding Educator in Diabetes Award for 2017. She delivered the address in June 2017 at the Association's 77th Annual Meeting and Scientific Sessions in San Diego, Calif. A webcast of the speech can be viewed on ADA's DiabetesPro website at
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
Brenda Montgomery
EDITOR'S NOTE: This article is adapted from a speech that Ms. Montgomery delivered as the American Diabetes Association's President of Health Care & Education at ADA's Annual Meeting and Scientific Sessions in June 2017, San Diego, Calif. A webcast of the speech can be viewed on ADA's DiabetesPro website at
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
Adam B Scanlan, Catarina M Maia, Alberly Perez, Carol J Homko, Matthew J O'Brien
Objective: Numerous validated questionnaires use self-reported data to quantify individuals' risk of having diabetes or developing it in the future. Evaluations of these tools have primarily used nationally representative data, limiting their application in clinical and community settings. This analysis tested the effectiveness of the American Diabetes Association (ADA) risk questionnaire for identifying prediabetes in a community-based sample of Latinas. Methods: Data were collected using the ADA risk questionnaire and assessing A1C...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
Max Bingham
Welcome to Diabetes Spectrum 's first installment of Diabetes is Primary, a round-up of the latest diabetes developments for health care providers. In this issue, we take a look at radical weight loss for diabetes remission, Hong Kong's diabetes risk assessment and management program, personalized A1C targets, and diabetes diagnoses. The American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) panel gives its verdict on continuous glucose monitoring (CGM) devices, and we learn how Medicare will soon pay for a diabetes prevention program...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
Dorte Vistisen, Daniel R Witte, Eric J Brunner, Mika Kivimäki, Adam Tabák, Marit E Jørgensen, Kristine Færch
OBJECTIVE: We compared the risk of cardiovascular disease (CVD) and all-cause mortality in subgroups of prediabetes defined by fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), or HbA 1c . RESEARCH DESIGN AND METHODS: In the Whitehall II cohort, 5,427 participants aged 50-79 years, without diabetes, were followed for a median of 11.5 years. A total of 628 (11.6%) had prediabetes by the World Health Organization (WHO)/International Expert Committee (IEC) criteria (FPG 6...
February 16, 2018: Diabetes Care
Krystal K Swasey, Trevor J Orchard, Tina Costacou
AIMS: DCCT showed that intensive type 1 diabetes management reduces complication incidence but did not focus on other cardiovascular disease risk factors, whose control in type 1 diabetes has not been well-studied. We assessed trends in cardiovascular risk factors in type 1 diabetes and attainment of concurrent American Diabetes Association (ADA) guidelines/recommendations (for HbA1c, blood pressure, LDL cholesterol, triglycerides) for complication prevention. METHODS: Individuals with childhood-onset type 1 diabetes (n = 658; 49...
January 10, 2018: Journal of Diabetes and its Complications
Rajib Paul, Chae Young Lim, Amy B Curtis, Tapabrata Maiti, Kathleen M Baker, Libertie B Mantilla, Elizabeth L MacQuillan
The purpose of this study is to identify regions with diabetes health-service shortage. American Diabetes Association (ADA)-accredited diabetes self-management education (DSME) is recommended for all those with diabetes. In this study, we focus on demographic patterns and geographic regionalization of the disease by including accessibility and availability of diabetes education resources as a critical component in understanding and confronting differences in diabetes prevalence, as well as addressing regional or sub-regional differences in awareness, treatment and control...
February 2018: Spatial and Spatio-temporal Epidemiology
Lei Lynn, Dana Kay, Naji Younes, Sabyasachi Sen, Vivek Jain
BACKGROUND: Diabetes Mellitus is one of the most common chronic diseases in the United States and worldwide. In 2009 the American Diabetes Association (ADA) recommended using A1C greater than 6.5% to diagnose diabetes. Hemoglobin A1C can be measured by laboratory and Point-of-Care (POC) methods. It is important to compare results obtained by the two modalities to determine the proper use of these tests. METHODS: One hundred fifteen patients were identified to have both POC and laboratory A1C values obtained on the same day, between August 2013 and August 2014...
February 6, 2018: Metabolic Syndrome and related Disorders
Sandra Hummel, Andreas Beyerlein, Markus Pfirrmann, Anna Hofelich, Daniela Much, Susanne Hivner, Melanie Bunk, Melanie Herbst, Claudia Peplow, Markus Walter, Denise Kohn, Nadine Hummel, Jürgen Kratzsch, Michael Hummel, Martin Füchtenbusch, Joerg Hasford, Anette-G Ziegler
OBJECTIVE: Women with insulin-requiring gestational diabetes mellitus (GDM) are at high risk of developing diabetes within a few years postpartum. We implemented this phase II study to test the hypothesis that vildagliptin, a dipeptidyl peptidase-4 inhibitor, is superior to placebo in terms of reducing the risk of postpartum diabetes. METHODS: Women with insulin-requiring GDM were randomized to either placebo or 50 mg vildagliptin twice daily for 24 months followed by a 12-month observation period (EudraCT: 2007-000634-39)...
January 3, 2018: Molecular Metabolism
Ilker Tasci, Umut Safer, Ilkin Naharci, Alper Sonmez
In recent years, modified glycemic targets have been defined for older adults with diabetes mellitus. In a sample of elderly patients, we have identified several inconsistencies between the real life applicability of glycated hemoglobin goals recommended by the American Diabetes Association and the American Geriatrics Society.
January 26, 2018: Primary Care Diabetes
Bin Song, Zhihua Zuo, Juan Tan, Jianjin Guo, Weiping Teng, Yibing Lu, Chao Liu
BACKGROUND: The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference. METHODS: The study included 1482 subjects (≥20 years of age; residing in Nanjing, China) receiving questionnaire interview, anthropometric measurements, laboratory tests and thyroid ultrasonography in 2009-2010...
January 27, 2018: BMC Endocrine Disorders
Alvaro Pérez, Pamela Rojas, Fernando Carrasco, Karen Basfi-Fer, Francisco Pérez-Bravo, Juana Codoceo, Jorge Inostroza, Manuel Ruz
Glucagon dysregulation is an essential component in the pathophysiology of type 2 diabetes. Studies in vitro and in animal models have shown that zinc co-secreted with insulin suppresses glucagon secretion. Zinc supplementation improves blood glucose control in patients with type 2 diabetes, although there is little information about how zinc supplementation may affect glucagon secretion. The objective of this study was to evaluate the effect of 1-year zinc supplementation on fasting plasma glucagon concentration and in response to intravenous glucose and insulin infusion in patients with type 2 diabetes...
January 26, 2018: Biological Trace Element Research
Xianfeng Zhou, Xiaonan Ruan, Lipeng Hao, Yi Zhou, Jianjun Gu, Hua Qiu, Kang Wu, Siyu Yu, Xinyi Rui, Xiaonan Wang, Xiaolin Liu, Juzhong Ke, Genming Zhao, Qiao Sun
AIMS: Due to the diversity of the Chinese population, it requires considerable research to evaluate HbA1c diagnostic threshold for diagnosis of hyperglycemia. METHODS: We included 7909 subjects aged ≥15 without known diabetes from the baseline of Pudong community cohort in 2013. Participants took oral glucose tolerance test (OGTT) and HbA1c assay. Receiver operating characteristic curve determined the HbA1c threshold in the diagnosis of hyperglycemia. RESULTS: The optimal HbA1C threshold for diagnosing newly diagnosed diabetes (NDD) and pre-diabetes in this population was 6...
January 20, 2018: Primary Care Diabetes
Cheng-Wei Chan, Chu-Leng Yu, Jiunn-Cherng Lin, Yu-Cheng Hsieh, Che-Chen Lin, Chen-Ying Hung, Cheng-Hung Li, Ying-Chieh Liao, Chu-Pin Lo, Jin-Long Huang, Ching-Heng Lin, Tsu-Juey Wu
OBJECTIVE: Metformin is the standard first-line drug for patients with Type 2 diabetes (T2DM). However, the optimal second-line oral anti-diabetic agent (ADA) remains unclear. We investigated the cardiovascular risk of various ADAs used as add-on medication to metformin in T2DM patients from a nationwide cohort. METHODS: T2DM patients using different add-on oral ADAs after an initial metformin therapy of > 90 days were identified from the Taiwan National Health Insurance Database...
January 24, 2018: Cardiovascular Diabetology
Sabina Paglialunga, Ryan Bond, Sharon H Jaycox
BACKGROUND: There are a number of obstacles which may impede the recruitment of underserved populations in clinical research studies; some of these factors include mistrust of medical research, socioeconomic constraints, cultural factors, and language barriers. For chronic metabolic disease indications, these barriers may also include lack of disease awareness. Recently, national organizations such as the American Diabetes Association (ADA) and Centers for Disease Control and Prevention (CDC) have highlighted the need for prediabetes recognition...
January 22, 2018: Trials
Mouaz H Al-Mallah, Sherif Sakr, Ada Al-Qunaibet
PURPOSE OF REVIEW: Cardiovascular diseases account for nearly one third of all deaths globally. Improving exercise capacity and cardiorespiratory fitness (CRF) has been an important target to reduce cardiovascular events. In addition, the American Heart Association defined decreased physical activity as the fourth risk factor for coronary artery disease. Multiple large cohort studies have evaluated the impact of CRF on outcomes. In this review, we will discuss the role of CRF in reducing cardiovascular morbidity and mortality...
January 16, 2018: Current Atherosclerosis Reports
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