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psp actinobacteria

Pratik Datta, Janani Ravi, Valentina Guerrini, Rinki Chauhan, Matthew B Neiditch, Scarlet S Shell, Sarah M Fortune, Baris Hancioglu, Oleg A Igoshin, Maria Laura Gennaro
The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important for survival. In Gram-negative bacteria, envelope integrity during stress is maintained by the multi-gene Psp response. Mycobacterium tuberculosis was thought to lack the Psp system since it encodes only pspA and no other psp ortholog. Intriguingly, pspA maps downstream from clgR, which encodes a transcription factor regulated by the MprAB-σ(E) envelope-stress-signaling system...
August 2015: Molecular Microbiology
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