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https://www.readbyqxmd.com/read/28437380/lifestyle-and-neurocognition-in-older-adults-with-cardiovascular-risk-factors-and-cognitive-impairment
#1
James A Blumenthal, Patrick J Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N Browndyke, Pao-Hwa Lin, William Kraus, P Murali Doraiswamy, James Burke, Andrew Sherwood
OBJECTIVE: To determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, without dementia (CIND). METHODS: One hundred sixty adults (Mean = 65.4±6.8 years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity determined by exercise testing, and dietary habits quantified by the Food Frequency Questionnaire and 4-Day Food Diary to assess adherence to the Mediterranean and DASH diets were obtained to assess direct effects with neurocognition...
April 21, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28434968/cardiac-contractility-correction-strategies-applied-to-telemetry-data-from-a-hesi-sponsored-consortium
#2
Emmanuel Boulay, Michael K Pugsley, Vincent Jacquemet, Alain Vinet, Michael V Accardi, Maxim Soloviev, Eric Troncy, Jennifer M Doyle, Jennifer Beck Pierson, Simon Authier
INTRODUCTION: QT has a long history of heart rate (HR) correction but limited investigations have been undertaken to assess the impact of cardiovascular parameters on left ventricular (LV) contractility in drug safety testing. Cardiac contractility is affected by preload (Cyon-Frank-Starling law), afterload (Anrep effect) and HR (Bowditch effect). We evaluated multi-parameter correction methods to help with dP/dtmax interpretation. METHODOLOGY: Modeling was undertaken using data from dogs in single or double 4×4 Latin square studies...
April 20, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28420806/the-association-of-occupational-metals-exposure-and-oxidative-damage-telomere-shortening-in-fitness-equipments-manufacturing-workers
#3
Jiunn-Liang Ko, Yu-Jung Cheng, Guan-Cen Liu, I-Lun Hsin, Hsiu-Ling Chen
The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants...
April 14, 2017: Industrial Health
https://www.readbyqxmd.com/read/28419387/effect-of-continuous-positive-airway-pressure-treatment-on-health-related-quality-of-life-and-sleepiness-in-high-cardiovascular-risk-individuals-with-sleep-apnea-best-apnea-interventions-for-research-bestair-trial
#4
Ying Y Zhao, Rui Wang, Kevin J Gleason, Eldrin F Lewis, Stuart F Quan, Claudia M Toth, Michael Morrical, Michael Rueschman, Jia Weng, James H Ware, Murray A Mittleman, Susan Redline
Study Objectives: The long term effect of continuous positive airway pressure (CPAP) on health-related quality of life (HRQOL) in patients with high cardiovascular disease risk and obstructive sleep apnea (OSA) without severe sleepiness is uncertain. We aimed to determine the effect of CPAP treatment on HRQOL in individuals with moderate or severe OSA and cardiovascular disease (CVD) or multiple CVD risk factors without severe sleepiness. Methods: In this randomized, controlled, parallel group study, 169 participants were assigned to treatment with CPAP or the control group (conservative medical therapy [CMT] or CMT with sham CPAP)...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28416902/a-first-look-into-the-influence-of-triathlon-wetsuit-on-resting-blood-pressure-and-heart-rate-variability
#5
A Prado, J Dufek, J Navalta, N Lough, J Mercer
The purpose of this study was to investigate the effects of wearing a wetsuit on resting cardiovascular measures (blood pressure (BP), heart rate variability (HRV)). The influence of position (upright, prone) and wetsuit size were also explored. Participants (n=12 males, 33.3±12.1 years) had BP and HRV measured during six resting conditions: standing or prone while not wearing a wetsuit (NWS), wearing the smallest (SWS), or largest (LWS) wetsuit (based upon manufacturer guidelines). Heart rate was recorded continuously over 5-mins; BP was measured three times per condition...
March 2017: Biology of Sport
https://www.readbyqxmd.com/read/28416154/a-comparison-of-dicarbonyl-stress-and-advanced-glycation-endproducts-in-lifelong-endurance-athletes-vs-sedentary-controls
#6
Martijn F H Maessen, Casper G Schalkwijk, Rebecca J H M Verheggen, Vincent L Aengevaeren, Maria T E Hopman, Thijs M H Eijsvogels
OBJECTIVES: Dicarbonyl stress and high concentrations of advanced glycation endproducts (AGEs) relate to an elevated risk for cardiovascular diseases (CVD). Exercise training lowers the risk for future CVD. We tested the hypothesis that lifelong endurance athletes have lower dicarbonyl stress and AGEs compared to sedentary controls and that these differences relate to a better cardiovascular health profile. DESIGN: Cross-sectional study. METHODS: We included 18 lifelong endurance athletes (ATH, 61±7years) and 18 sedentary controls (SED, 58±7years) and measured circulating glyoxal (GO), methylglyoxal (MGO) and 3-deoxyglucosone (3DG) as markers of dicarbonyl stress...
March 23, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28408830/twelve-week-physical-exercise-does-not-have-a-long-lasting-effect-on-kynurenines-in-plasma-of-depressed-patients
#7
Vincent Millischer, Sophie Erhardt, Örjan Ekblom, Yvonne Forsell, Catharina Lavebratt
BACKGROUND: Physical exercise has well-characterized positive effects on depressive symptoms. The underlying biologic mechanisms are, however, far from established. A recently discovered mechanism has linked the enhanced conversion of kynurenine to kynurenic acid (KYNA) to an increased resilience toward stress-induced depression in mice. The aim of this study was to translate these findings to humans. MATERIALS AND METHODS: Kynurenine and KYNA levels were measured by high-performance liquid chromatography in plasma samples from 117 patients affected by mild-to-moderate depression before and within a week after a 12-week training period at three different intensities...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28406763/do-women-with-fibromyalgia-present-higher-cardiovascular-disease-risk-profile-than-healthy-women-the-al-%C3%A3-ndalus-project
#8
Pedro Acosta-Manzano, Víctor Segura-Jiménez, Fernando Estévez-López, Inmaculada C Álvarez-Gallardo, Alberto Soriano-Maldonado, Milkana Borges-Cosic, Blanca Gavilán-Carrera, Manuel Delgado-Fernández, Virginia A Aparicio
OBJECTIVES: To analyse the cardiovascular disease risk profile of women with fibromyalgia and compare it with control women; and to test whether physical activity is associated with the cardiovascular disease risk profile in this population. METHODS: This cross-sectional study comprised 436 women with fibromyalgia (51.4±7.5 years old) and 217 controls (48.4±9.6 years old) from Andalusia, Spain. Clinical data, waist circumference, body fat percentage, resting heart rate, blood pressure and cardiorespiratory fitness were assessed...
April 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28406104/institutionalized-physical-activity-curriculum-benefits-of-medical-students-in-colombia
#9
Gustavo Tovar, Gabriel López, Milcíades Ibáñez, Ricardo Alvarado, Felipe Lobelo, John Duperly
BACKGROUND: Health authorities internationally have recommended implementing physical activity and exercise for health training programs within the curriculum of medical schools. The purpose of this evaluation was to determine the changes in physical fitness and health (Fitnessgram criteria) of a sports medicine and physical activity course implemented for 3rd year students in a private medical school in Bogotá, Colombia. METHODS: Intervention was targeted to 13 medical student cohorts...
September 2016: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28403561/iron-deficiency-anemia-in-chronic-kidney-disease-uncertainties-and-cautions
#10
Rajiv Agarwal
Anemia in chronic kidney disease is common and iron deficiency is an important cause. To repair iron-deficiency anemia, replacement of iron is needed. Iron can be replaced either by the oral route or by the intravenous route. In a meta-analysis, 5 of the 6 trials were short-term, 1 to 3 months, and compared to oral iron, the mean increase in hemoglobin with intravenous iron was only 0.31 g/dL. However, one of the studies included in this meta-analysis was 6 months long and had a mean decline in hemoglobin of 0...
April 12, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28401618/tailoring-mineralocorticoid-receptor-antagonist-therapy-in-heart-failure-patients-are-we-moving-towards-a-personalized-approach
#11
REVIEW
João Pedro Ferreira, Robert J Mentz, Anne Pizard, Bertram Pitt, Faiez Zannad
The aim of personalized medicine is to offer a tailored approach to each patient in order to provide the most effective therapy, while reducing risks and side effects. The use of mineralocorticoid receptor antagonists (MRAs) has demonstrated major benefits in heart failure with reduced ejection fraction (HFrEF), results with challenging inconsistencies in heart failure with preserved ejection fraction (HFpEF), and 'neutral' preliminary results in acute heart failure. Data derived from landmark trials are generally applied in a 'one size fits all' manner and the development and implementation of more personalized MRA management would offer the potential to improve outcomes and reduce side effects...
April 12, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28401139/family-physician-led-team-based-lifestyle-intervention-in-patients-with-metabolic-syndrome-results-of-a-multicentre-feasibility-project
#12
Khursheed Jeejeebhoy, Rupinder Dhaliwal, Daren K Heyland, Roger Leung, Andrew G Day, Paula Brauer, Dawna Royall, Angelo Tremblay, David M Mutch, Lew Pliamm, Caroline Rhéaume, Doug Klein
BACKGROUND: Metabolic syndrome (MetS) is a medical condition with major complications and health care costs. Previous research has shown that diet and exercise can improve and reverse this condition. The goal of this study was to test the feasibility and effectiveness of implementing the Canadian Health Advanced by Nutrition and Graded Exercise (CHANGE) program into diverse family medicine practices to improve MetS. METHODS: In this longitudinal before-after study, 305 adult patients with MetS were recruited from 3 diverse family medicine team-based organizations to the CHANGE personalized diet and exercise program...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28400918/patient-selection-for-transcatheter-aortic-valve-replacement-a-combined-clinical-and-multimodality-imaging-approach
#13
REVIEW
Rosangela Cocchia, Antonello D'Andrea, Marianna Conte, Massimo Cavallaro, Lucia Riegler, Rodolfo Citro, Cesare Sirignano, Massimo Imbriaco, Maurizio Cappelli, Giovanni Gregorio, Raffaele Calabrò, Eduardo Bossone
Transcatheter aortic valve replacement (TAVR) has been validated as a new therapy for patients affected by severe symptomatic aortic stenosis who are not eligible for surgical intervention because of major contraindication or high operative risk. Patient selection for TAVR should be based not only on accurate assessment of aortic stenosis morphology, but also on several clinical and functional data. Multi-Imaging modalities should be preferred for assessing the anatomy and the dimensions of the aortic valve and annulus before TAVR...
March 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28398943/cardiorespiratory-fitness-and-risk-of-fatty-liver-the-young-finns-study
#14
Kristiina S Pälve, Katja Pahkala, Emmi Suomela, Heikki Aatola, Janne Hulkkonen, Markus Juonala, Terho Lehtimäki, Tapani Rönnemaa, Jorma S A Viikari, Mika Kähönen, Nina Hutri-Kähönen, Risto Telama, Tuija Tammelin, Olli T Raitakari
PURPOSE: Fatty liver is an expanding health concern associated with metabolic disturbances and increased risk of cardiovascular disease. Experimental studies in animals have shown associations between fatty liver and cardiorespiratory fitness but limited data exist in humans. The aim of this study was to analyze the links between cardiorespiratory fitness and fatty liver in a population based sample of adults. METHODS: Participants were 463 adults (48% males) from the Cardiovascular Risk in Young Finns Study...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28391877/influence-of-sedentary-behavior-physical-activity-and-cardiorespiratory-fitness-on-the-atherogenic-index-of-plasma
#15
Meghan K Edwards, Michael J Blaha, Paul D Loprinzi
BACKGROUND: Atherogenic index of plasma (AIP), calculated as LOG10 (triglycerides/high-density lipoprotein-cholesterol), may have greater utility over other metrics in predicting risk for cardiovascular disease (CVD). Previous work demonstrates the associations of physical activity (PA), sedentary behavior, and cardiorespiratory fitness (CRF) with triglycerides high-density lipoprotein (HDL-C) and CVD. OBJECTIVE: Limited research has examined these parameters and their potential additive associations with AIP, which was the purpose of this study...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28390681/relation-between-estimated-cardiorespiratory-fitness-and-atrial-fibrillation-from-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#16
Abhishek Bose, Wesley T O'Neal, Aleena Bennett, Suzanne E Judd, Waqas T Qureshi, Xuemei Sui, Virginia J Howard, George Howard, Elsayed Z Soliman
Estimated cardiorespiratory fitness (e-CRF) based on readily available clinical and self-reported data is a promising alternative to the costly traditional assessment of CRF using exercise equipment, but its role as a predictor for incident atrial fibrillation (AF) is unclear. This study included 10,126 participants (54.5% women, 35% African-American, mean age 63.2 years) from the Reasons for Geographic and Racial Differences in Stroke study who were free of AF at baseline. Baseline (2003 to 2007) e-CRF was determined using a previously validated nonexercise algorithm...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28385556/high-intensity-interval-training-for-maximizing-health-outcomes
#17
REVIEW
Trine Karlsen, Inger-Lise Aamot, Mark Haykowsky, Øivind Rognmo
Regular physical activity and exercise training are important actions to improve cardiorespiratory fitness and maintain health throughout life. There is solid evidence that exercise is an effective preventative strategy against at least 25 medical conditions, including cardiovascular disease, stroke, hypertension, colon and breast cancer, and type 2 diabetes. Traditionally, endurance exercise training (ET) to improve health related outcomes has consisted of low- to moderate ET intensity. However, a growing body of evidence suggests that higher exercise intensities may be superior to moderate intensity for maximizing health outcomes...
April 3, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28385161/myocardial-perfusion-cardiovascular-magnetic-resonance-optimized-dual-sequence-and-reconstruction-for-quantification
#18
Peter Kellman, Michael S Hansen, Sonia Nielles-Vallespin, Jannike Nickander, Raquel Themudo, Martin Ugander, Hui Xue
BACKGROUND: Quantification of myocardial blood flow requires knowledge of the amount of contrast agent in the myocardial tissue and the arterial input function (AIF) driving the delivery of this contrast agent. Accurate quantification is challenged by the lack of linearity between the measured signal and contrast agent concentration. This work characterizes sources of non-linearity and presents a systematic approach to accurate measurements of contrast agent concentration in both blood and myocardium...
April 7, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28384359/a-mechanistic-model-for-atherosclerosis-and-its-application-to-the-cohort-of-mayak-workers
#19
Cristoforo Simonetto, Tamara V Azizova, Zarko Barjaktarovic, Johann Bauersachs, Peter Jacob, Jan Christian Kaiser, Reinhard Meckbach, Helmut Schöllnberger, Markus Eidemüller
We propose a stochastic model for use in epidemiological analysis, describing the age-dependent development of atherosclerosis with adequate simplification. The model features the uptake of monocytes into the arterial wall, their proliferation and transition into foam cells. The number of foam cells is assumed to determine the health risk for clinically relevant events such as stroke. In a simulation study, the model was checked against the age-dependent prevalence of atherosclerotic lesions. Next, the model was applied to incidence of atherosclerotic stroke in the cohort of male workers from the Mayak nuclear facility in the Southern Urals...
2017: PloS One
https://www.readbyqxmd.com/read/28381219/cardiorespiratory-fitness-levels-and-associations-with-physical-activity-and-body-composition-in-young-south-african-adults-from-soweto
#20
A Prioreschi, S Brage, K Westgate, S A Norris, L K Micklesfield
BACKGROUND: This observational study aims to describe fitness, and objectively measured physical activity levels and patterns in 409 young black South African adults (aged 19-20 years) from Soweto, as well as to examine associations between physical activity, fitness and BMI. METHODS: A sub-maximal ramped step test was used to obtain an estimate of maximal oxygen uptake (VO2max). Physical activity was measured using ActiGraph (GT1M) for 7 days in 256 participants...
April 5, 2017: BMC Public Health
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