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histoid leprosy

Maria J M Canuto, Carolina R D Yacoub, Maria A B Trindade, Joao Avancini, Carla Pagliari, Mirian N Sotto
BACKGROUND: Histoid leprosy (HL) is a rare form of lepromatous leprosy, characterized by hyperchromic indurated nodules above normal skin. Its main histopathological aspect is spindle cells. Because it may simulate other aspects, such as dermatofibroma and neurofibroma, histoid leprosy poses itself as a diagnostic challenge. METHODS: This is a retrospective study with all patients having been selected from the leprosy clinic of the Hospital das Clínicas da Universidade de São Paulo from 2006 to 2016...
January 31, 2018: International Journal of Dermatology
Jingru Sun, Ping Tu, Shengguo Yi, Wenjing Fu, Yang Wang
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
Renata Borges Fortes da Costa Figueira, Karen Fernandes de Oliveira, Luciana Borges de Souza, Gustavo Henrique Soares Takano, Jorgeth de Oliveira Carneiro da Motta, Izelda Maria Carvalho Costa
Wade's histoid leprosy (HL) is a rare variant of multibacillary leprosy, with characteristic clinical, immunologic, histopathologic, and bacteriologic features. It is associated with resistance to sulfa drugs or polychemotherapy and is rarely observed in patients who have not undergone prior treatment. Clinically, HL resembles keloid or dermatofibroma. Furthermore, HL is rare in children and is difficult to diagnose even by experts. This report describes a case of HL in a 14-year-old Brazilian boy, who presented with multiple nodular and tumor-like lesions, simulating keloids...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
Balachandra S Ankad, Punit S Sakhare
No abstract text is available yet for this article.
April 2017: Dermatology Practical & Conceptual
Mahesh Mathur, Ayush Jha, Ruprerna Joshi, Roshani Wagle
BACKGROUND: Histoid leprosy is a rare variant of lepromatous leprosy characterized by varied morphological and histopathological appearance while having a high bacillary load. These factors contribute to an ominous threat to the elimination status of leprosy, whereby these patients may act as a reservoir of infection. OBJECTIVE: To identify the clinicopathological characteristics of histoid leprosy in Chitwan, Nepal. METHODS: A retrospective hospital-based study spanning a period of 6 years was carried out at our department...
March 21, 2017: International Journal of Dermatology
Aditya Kumar Bubna
No abstract text is available yet for this article.
November 2016: Indian Journal of Dermatology
Angoori Gnaneshwar Rao
Coexistence of two immunologically diverse forms of leprosy in an individual is very rare. Herein, we report a case of association of borderline tuberculoid (BT) leprosy with histoid leprosy (HL) in a young immune competent male. He was diagnosed as a case of BT leprosy 10 years ago and now presented with multiple papules and nodules. Histopathological examination of biopsy taken from patch and nodule showed features of BT and HL, respectively.
September 2016: Indian Journal of Dermatology
Virginia Coelho de Sousa, Andre Laureano, Jorge Cardoso
An 18-year-old man presented with a 4-year history of erythematous patches on the trunk, followed 2-years later by multiple nodules, mostly located on the limbs, and distal paresthesias. Two close contacts were treated for leprosy during his childhood. Histopathological examination revealed a histiocytic infiltrate with acid-fast bacilli on Ziehl-Neelsen stain. The slit-skin and nasal smears showed numerous acid-fast bacilli. The correlation between clinical, epidemiological, histopathological, and microbiological features allowed the diagnosis of lepromatous leprosy, histoid variant...
February 17, 2016: Dermatology Online Journal
Srabani Chakrabarti, Subrata Pal, Biplab Kr Biswas, Kingshuk Bose, Saswati Pal, Swapan Pathak
BACKGROUND: Granulomatous dermatoses are common skin pathology, often need histopathological confirmation for diagnosis. Histologically six sub-types of granulomas found in granulomatous skin diseases- tuberculoid, sarcoidal, necrobiotic, suppurative, foreign body & histoid type. The aims of the present study were clinico-pathological evaluation of granulomatous skin lesions and their etiological classification based on histopathological examination. METHODS: It was a five years (Jan 2009- Dec 2013) retrospective study involving all the skin biopsies...
2016: Iranian Journal of Pathology
Guiying Zhang, Hui Jin, Huan Chen, Qianjin Lu
No abstract text is available yet for this article.
November 7, 2015: Lancet
Pedro Jose Secchin de Andrade, Sulamita Dos Santos Nascimento Dutra Messias, Paola Cristina Brandão Oliveira Ferreira, Anna Maria Sales, Alice de Miranda Machado, José Augusto da Costa Nery
Leprosy is a neglected disease. We point up the need of recognizing the unusual clinical presentations of the disease in order to make early diagnosis and proper treatment possible, and break the transmission chain. The authors report a rare type of multibacillary leprosy: histoid leprosy and present images of numerous well-circumscribed indurated papules and nodules distributed throughout the entire body.
September 2015: Anais Brasileiros de Dermatologia
Pooja Pandey, Mavinrkainahalli Srinivasa Murthy Suresh, Vivek Kumar Dey
Histoid leprosy is an uncommon entity with specific clinical, histopathological and bacteriological features. Histoid lepromas are sudden eruption of dome shaped lesions usually associated with dapsone resistance, as a variant of lepromatous leprosy or rarely arising de novo. We report a case who presented for the first time with histoid features with no history of taking dapsone/antileprosy treatment earlier in an elderly male with small to large lesions over normal skin in the post-leprosy elimination era...
September 2015: Indian Journal of Dermatology
Gerzaín Rodriguez, Rafael Henríquez, Shirley Gallo, César Panqueva
This work was conducted at the Facultad de Medicina, Universidad de La Sabana, and at the Facultad de Medicina, Universidad Surcolombiana. Histoid leprosy, a clinical and histological variant of multibacillary leprosy, may offer a challenging diagnosis even for experts. An 83-year-old woman presented with papular, nodular and tumor-like lesions of 3 years of evolution, affecting fingers, toes, hands, thighs and knees, and wide superficial ulcers in her lower calves. Cutaneous lymphoma was suspected. A biopsy of a nodule of the knee showed a diffuse dermal infiltrate with microvacuolated histiocytes, moderate numbers of lymphocytes and plasma cells...
April 2015: Biomédica: Revista del Instituto Nacional de Salud
B A Kolaparambath, R Rajagopal
A 46 year old male diagnosed case of Acquired Immuno Deficiency Syndrome (AIDS) on Highly Active Anti Retroviral Therapy (HAART) presented with raised nodular skin lesions of two months duration which on skin biopsy was diagnosed as Histoid leprosy. Individual was put on standard Multi Bacillary Multi Drug Therapy (MB MDT) for two months has shown exacerbation of lesion and was later put on daily Rifampicin, Ofloxacin and Minocycline (ROM) for which he responded. Interesting feature is rarity of association of HIV with Histoid Leprosy where the patient did not respond to the conventional MB MDT and later responded to daily ROM...
October 2014: Indian Journal of Leprosy
Keshavamurthy Vinay, Tarun Narang, Chougule Abhijit, Sunil Dogra
No abstract text is available yet for this article.
November 2015: International Journal of Dermatology
Santosh K Swain, Ajay K Jena, Maitreyee Panda, Debahuti Mohapatra, Nibedita Patro, Mahesh C Sahu
Histoid Hansen's disease is a rare form of multibacillary leprosy with distinct clinical and histopathological features. This type of leprosy is a variant of lepromatous leprosy with a very high bacterial reserve. Of alarming concern is the discovery of an isolated mucosal histoid leprotic lesion inside the nasal cavity of a patient in the post-global leprosy elimination era. Our case had no history of leprosy or exposure to dapsone/multidrug therapy but had a heavy bacillary index. We are reporting this case to highlight the rarity of mucosal lesions due to histoid leprosy and involvement of the nasal cavity, as well as to create awareness and avoid misdiagnosis...
November 2015: Journal of Infection and Public Health
Sunil Kumar Gupta
Leprosy is a chronic granulomatous inflammation primarily of the peripheral nervous system, skin, and reticuloendothelial system caused by Mycobacterium leprae. It presents clinically as an erythematous or hypopigmented anesthetic patch and a thickened and/or tender cutaneous nerve trunk. Leprosy is also called Hansen disease. Leprosy is a great imitator of other skin diseases, and it can present with different morphological lesions, which is why an expert eye is needed to diagnose it. One of the important clinical presentations of leprosy is histoid leprosy, which is very difficult to diagnose due to different clinical and histopathological findings that mimic, e...
November 2015: International Journal of Dermatology
Kaliaperumal Karthikeyan
No abstract text is available yet for this article.
June 2015: American Journal of Tropical Medicine and Hygiene
Yasmeen J Bhat, Iffat Hassan, Atiya Yaseen, Rohi Wani
Histoid leprosy is an uncommon variant of lepromatous leprosy that usually follows treatment failure. Occasionally it occurs de novo without any history of previous inadequate or irregular treatment. We, hereby, report a case of de novo histoid leprosy in a 25-year-old man from the post-elimination area of Kashmir, where the prevalence rate of the disease was reported to be 0.17/10000 in March, 2013 (NLEP).
March 2015: Indian Journal of Dermatology
Sunil Dogra, Tarun Narang, Geeti Khullar, Ramesh Kumar, Uma Nahar Saikia
BACKGROUND: Children are believed to be the most vulnerable group for leprosy and childhood leprosy reflects disease transmission in the community as well as the efficiency of ongoing disease control programmes. Objectives: To study the epidemiological and clinical trends of childhood cases of leprosy at a tertiary care hospital in North India during 2001-2011. METHODS: A retrospective study was undertaken analysing the clinic records of children with leprosy less than or equal to 18 years registered at the leprosy clinic of this institute over an 11-year period...
December 2014: Leprosy Review
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