Thabatta Leal Silveira Andrezo Rosa, Mayara Abud Mendes, Natasha Ribeiro Cardoso Linhares, Thais Fernanda Rodrigues, André Alves Dias, Thyago Leal-Calvo, Mariana Gandini, Helen Ferreira, Fabrício da Mota Ramalho Costa, Anna Maria Sales, Thaís Porto Amadeu, Veronica Schmitz, Roberta Olmo Pinheiro, Luciana Silva Rodrigues, Milton Ozório Moraes, Maria Cristina Vidal Pessolani
In leprosy patients, acute inflammatory episodes, known as erythema nodosum leprosum (ENL), are responsible for high morbidity and tissue damage that occur during the course of Mycobacterium leprae infection. In a previous study, we showed evidence implicating DNA-sensing via TLR9 as an important inflammatory pathway in ENL. A likely important consequence of TLR9 pathway activation is the production of type I interferons (IFN-I) by plasmacytoid dendritic cells (pDCs), also implicated in the pathogenesis of several chronic inflammatory diseases...
2022: Frontiers in Medicine