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erythema nodosum leprosum

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https://www.readbyqxmd.com/read/27859670/leprosy-reactions-in-post-elimination-stage-the-bangladesh-experience
#1
Mohammad Rafiqul Mowla, Shamim Ara, Afm Mizanur Rahman, Sanai Prue Tripura, Sujat Paul
BACKGROUND: Leprosy reactions are immunologically mediated conditions and a major cause of disability before, during and after multidrug therapy. Little data has been published on the epidemiology of leprosy reactions in Bangladesh. OBJECTIVES: To describe the pattern and prevalence of leprosy reactions in the post elimination stage. METHODS: A descriptive retrospective cross-sectional study was carried out in Chittagong Medical College Hospital using the registered records of patients the periods between 2004 and 2013...
November 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27728405/erythema-nodosum-leprosum-as-a-cause-of-pyrexia-of-unknown-origin
#2
N S Kochar, B Sehgal, B Kanish, K Kwatra, L Solomon
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27699251/cell-type-deconvolution-with-immune-pathways-identifies-gene-networks-of-host-defense-and-immunopathology-in-leprosy
#3
Megan S Inkeles, Rosane M B Teles, Delila Pouldar, Priscila R Andrade, Cressida A Madigan, David Lopez, Mike Ambrose, Mahdad Noursadeghi, Euzenir N Sarno, Thomas H Rea, Maria T Ochoa, M Luisa Iruela-Arispe, William R Swindell, Tom H M Ottenhoff, Annemieke Geluk, Barry R Bloom, Matteo Pellegrini, Robert L Modlin
Transcriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides an outstanding model to study host defense and pathogenesis in a human infectious disease, given its clinical spectrum, which interrelates with the host immunologic and pathologic responses. Here, we investigated gene expression profiles derived from skin lesions for each clinical subtype of leprosy, analyzing gene coexpression modules by cell-type deconvolution...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27559497/quality-of-life-in-patients-with-erythema-nodosum-leprosum-in-kuala-lumpur-malaysia
#4
Felix B Yap, Sze T Kiung, Jeffrey B Yap
BACKGROUND: There is a paucity of data on quality of life issues in patients with leprosy suffering from erythema nodosum leprosum (ENL). Thus, we aim to study the effect of ENL on quality of life. MATERIALS AND METHODS: This cross-sectional study was conducted in Hansen's Clinic, Hospital Kuala Lumpur between January 2010 and December 2013 among patients with multibacillary leprosy using the Dermatology Life Quality Index (DLQI). RESULTS: A total of 153 patients participated with 31...
July 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27556927/expression-of-cd64-on-circulating-neutrophils-favoring-systemic-inflammatory-status-in-erythema-nodosum-leprosum
#5
Veronica Schmitz, Rhana Berto da Silva Prata, Mayara Garcia de Mattos Barbosa, Mayara Abud Mendes, Sheila Santos Brandão, Thaís Porto Amadeu, Luciana Silva Rodrigues, Helen Ferreira, Fabrício da Mota Ramalho Costa, Jessica Brandão Dos Santos, Fabiana Dos Santos Pacheco, Alice de Miranda Machado, José Augusto da Costa Nery, Mariana de Andrea Hacker, Anna Maria Sales, Roberta Olmo Pinheiro, Euzenir Nunes Sarno
Erythema Nodosum Leprosum (ENL) is an immune reaction in leprosy that aggravates the patient´s clinical condition. ENL presents systemic symptoms of an acute infectious syndrome with high leukocytosis and intense malaise clinically similar to sepsis. The treatment of ENL patients requires immunosuppression and thus needs to be early and efficient to prevent both disabilities and permanent nerve damage. Some patients experience multiple episodes of ENL and prolonged use of immunosuppressive drugs may lead to serious adverse effects...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27474073/dna-sensing-via-tlr-9-constitutes-a-major-innate-immunity-pathway-activated-during-erythema-nodosum-leprosum
#6
André A Dias, Camila O Silva, João Pedro S Santos, Leonardo R Batista-Silva, Chyntia Carolina D Acosta, Amanda N B Fontes, Roberta O Pinheiro, Flávio A Lara, Alice M Machado, José Augusto C Nery, Euzenir N Sarno, Geraldo M B Pereira, Maria Cristina V Pessolani
The chronic course of lepromatous leprosy may be interrupted by acute inflammatory episodes known as erythema nodosum leprosum (ENL). Despite its being a major cause of peripheral nerve damage in leprosy patients, the immunopathogenesis of ENL remains ill-defined. Recognized by distinct families of germline-encoded pattern recognition receptors, endogenous and pathogen-derived nucleic acids are highly immunostimulatory molecules that play a major role in the host defense against infections, autoimmunity, and autoinflammation...
September 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27444702/immunohistochemical-assessment-of-cell-populations-in-leprosy-spectrum-lesions-and-reactional-forms
#7
Luciana Raquel Vincenzi Fachin, Cleverson Teixeira Soares, Andrea de Faria Fernandes Belone, Ana Paula Favaro Trombone, Patrícia Sammarco Rosa, Cássio Cesar Guidella, Marcello Fabiano Franco
In situ immunophenotyping of leprosy lesions can improve our understanding of the biology of inflammatory cells during the immune response to Mycobacterium leprae antigens. In the present study, biopsies from 10 healthy controls and 70 leprosy patients were selected, 10 for each of the following conditions: clinical tuberculoid (TT), borderline tuberculoid (BT), borderline borderline (BB), borderline lepromatous (BL), lepromatous (LL), reversal reaction (R1), and erythema nodosum leprosum (R2). Qualitative and quantitative immunohistochemical analyses were performed to detect CD3, CD4, CD8, FoxP3, CD20, CD138, CD1a, CD57, CD15, CD117, CD68, and CD163...
July 22, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27342409/male-fertility-and-skin-diseases
#8
M Badawy Abdel-Naser, Christos C Zouboulis
Male fertility can be affected by a variety of organs diseases, including the skin. Several genodermatoses affect the skin and several other organs including the male reproductive system, commonly in the form of cryptorchidism and hypogonadism. The most relevant syndromes are associated with dyschromias, such as deSanctis-Cacchione, poikiloderma congenital, LEOPARD, and H syndrome; others with ichthyosis, such as Rud, and trichothiodystrophy; or a group of unrelated genodermatoses, such as ablepharon macrostomia, Coffin-Siris, Gorlin-Goltz, and Werner...
June 25, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27242236/treatment-of-severe-refractory-erythema-nodosum-leprosum-with-tumor-necrosis-factor-inhibitor-etanercept
#9
Sundeep Chowdhry, Akhilesh Shukla, Paschal D'souza, Tapan Dhali, Prashansa Jaiswal
Erythema nodosum leprosum (ENL) is a common complication of lepromatous leprosy. Some patients unresponsive to conventional, first-line therapeutics develop recurrent, recalcitrant ENL. Here, we report a case of severe refractory ENL that was successfully treated with Etanercept. Biologics may be considered as therapeutic alternatives in management of severe, recalcitrant ENL.
June 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27035913/leprosy-reactions-show-increased-th17-cell-activity-and-reduced-foxp3-tregs-with-concomitant-decrease-in-tgf-%C3%AE-and-increase-in-il-6
#10
Chaman Saini, Anisuddin Siddiqui, Venkatesh Ramesh, Indira Nath
BACKGROUND: 50% of leprosy patients suffer from episodes of Type 1/ reversal reactions (RR) and Type 2/ Erythema Nodosum Leprosum (ENL) reactions which lead to morbidity and nerve damage. CD4+ subsets of Th17 cells and CD25+FOXP3+ regulatory T cells (Tregs) have been shown to play a major role in disease associated immunopathology and in stable leprosy as reported by us and others. The aim of our study was to analyze their role in leprosy reactions. METHODOLOGY AND PRINCIPLE FINDINGS: Quantitative reverse transcribed PCR (qPCR), flowcytometry and ELISA were used to respectively investigate gene expression, cell phenotypes and supernatant levels of cytokines in antigen stimulated PBMC cultures in patients with stable disease and those undergoing leprosy reactions...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26989632/serum-uric-acid-levels-during-leprosy-reaction-episodes
#11
Yvelise T Morato-Conceicao, Eduardo R Alves-Junior, Talita A Arruda, Jose C Lopes, Cor J F Fontes
Background. Leprosy reactions are acute inflammatory episodes that occur mainly in the multibacillary forms of the disease. The reactions are classified as type 1 (reverse reaction) or type 2 (erythema nodosum leprosum). Leprosy-associated oxidative stress has been widely demonstrated. Several recent studies have shown uric acid (UA) to have antioxidative effects under pathologic conditions. The objective of this study was to assess serum levels of UA in patients with leprosy reactions, with the aim of monitoring their levels before and after treatment, compared with levels in leprosy patients without reactions...
2016: PeerJ
https://www.readbyqxmd.com/read/26964440/erythema-nodosum-leprosum-international-study-group-3rd-enlist-meeting-report-mumbai-7th-9th-april-2015
#12
Steve Walker, Diana Lockwood
No abstract text is available yet for this article.
December 2015: Leprosy Review
https://www.readbyqxmd.com/read/26964439/hemophagocytic-lymphohistiocytosis-in-leprosy
#13
Liv R Høyvoll, Yngvar Fløisand, Hilde Lang Orrem, Ragnar Gunnarsson, Linn Landrø, Trine Brevig, Peter Gaustad, Ingvild Nordøy
A patient from Southeast Asia was diagnosed with systemic lupus erythematosus. One year later, she experienced exacerbation of skin lesions and was diagnosed with erythema nodosum leprosum. Upon treatment, the patient developed hemophagocytic lymphohistiocytosis with multi-organ failure and died from invasive fungal infection. Hemophagocytic lymphohistiocytosis has to our knowledge, not previously been reported in leprosy.
December 2015: Leprosy Review
https://www.readbyqxmd.com/read/26964436/bullous-erythema-nodosum-leprosum-masquerading-as-systemic-onset-juvenile-idiopathic-arthritis-a-case-report
#14
Swetalina Pradhan, Bibhu Prasad Nayak, Tanmay Padhi, Madhusmita Sethy
No abstract text is available yet for this article.
December 2015: Leprosy Review
https://www.readbyqxmd.com/read/26964425/erythema-nodosum-leprosum-research-enlisting-support
#15
EDITORIAL
Stephen L Walker, Diana N Lockwood
No abstract text is available yet for this article.
December 2015: Leprosy Review
https://www.readbyqxmd.com/read/26919207/comparison-of-efficacy-and-safety-of-ciclosporin-to-prednisolone-in-the-treatment-of-erythema-nodosum-leprosum-two-randomised-double-blind-controlled-pilot-studies-in-ethiopia
#16
RANDOMIZED CONTROLLED TRIAL
Saba M Lambert, Shimelis D Nigusse, Digafe T Alembo, Stephen L Walker, Peter G Nicholls, Munir H Idriss, Lawrence K Yamuah, Diana N J Lockwood
BACKGROUND: Erythema Nodosum Leprosum (ENL) is a serious complication of leprosy. It is normally treated with high dose steroids, but its recurrent nature leads to prolonged steroid usage and associated side effects. There is little evidence on the efficacy of alternative treatments for ENL, especially for patients who have become steroid resistant or have steroid side effects. These two pilot studies compare the efficacy and side effect profile of ciclosporin plus prednisolone against prednisolone alone in the treatment of patients with either new ENL or chronic and recurrent ENL...
February 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26829382/the-308-bp-tnf-gene-polymorphism-influences-tumor-necrosis-factor-expression-in-leprosy-patients-in-bahia-state-brazil
#17
Joyce Moura Oliveira, Jamile Leão Rêgo, Nadja de Lima Santana, Marcos Braz, Sarra E Jamieson, Thaillamar Silva Vieira, Thaís Lamêgo Magalhães, Paulo Roberto Lima Machado, Jenefer M Blackwell, Léa C Castellucci
Leprosy or Hansen's disease is a debilitating chronic granulomatous disease caused by Mycobacterium leprae, with high incidence and prevalence in Brazil. The -308 bp G/A single nucleotide polymorphism (SNP rs1800629) in the tumor necrosis factor (TNF) gene promoter is a proposed risk factor for leprosy. In Brazil, Northern India, Egypt and Nepal, the common G allele was associated with leprosy. In Eastern India, Thailand and Malawi the minor A allele was the risk factor. Allele A was previously associated with high TNF...
April 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/26810580/the-demographic-and-clinical-characteristics-of-leprosy-in-saudi-arabia
#18
Mohammad H Alotaibi, Salman A Bahammam, Saeed Ur Rahman, Ahmed A Bahnassy, Imad S Hassan, Adel F Alothman, Abdulkareem M Alkayal
Leprosy is a chronic disease caused by Mycobacterium leprae. Although the occurrence of leprosy has declined in Saudi Arabia, it has not yet been eradicated. To our knowledge, this descriptive retrospective study is the first to assess the clinical presentation of leprosy at the time of diagnosis in Saudi Arabia. All study subjects were leprosy patients admitted to Ibn Sina hospital, the only referral hospital for leprosy in Saudi Arabia, between January 2000 and May 2012. A total of 164 subjects, the majority of whom (65%) were between 21 and 50 years of age, were included, and the male-to-female ratio was 2...
September 2016: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/26591847/unusual-presentation-of-necrotic-erythema-nodosum-leprosum-on-scalp-a-case-report
#19
K D Barman, A Madan, V K Garg, K Goel, N Khurana
Lepra reactions are acute episodes occurring during the disease process of leprosy and are of 2 types: type 1 or reversal reaction and type 2 reaction or erythema odosumleprosum (ENL). In the episodes of lepra reaction several parts are affected including face and extremities like oral cavity. In the present case report we reported a rare case of lepromatous leprosy with necrotic ENL involving scalp apart from the usual sites. A 58 year old married male presented to us with complaints of spontaneous onset, recurrent eruption of multiple reddish raised painful lesions...
January 2015: Indian Journal of Leprosy
https://www.readbyqxmd.com/read/26351858/enlist-1-an-international-multi-centre-cross-sectional-study-of-the-clinical-features-of-erythema-nodosum-leprosum
#20
MULTICENTER STUDY
Stephen L Walker, Marivic Balagon, Joydeepa Darlong, Shimelis N Doni, Deanna A Hagge, Vikas Halwai, Annamma John, Saba M Lambert, Armi Maghanoy, Jose A C Nery, Kapil D Neupane, Peter G Nicholls, Vivek V Pai, Pawan Parajuli, Anna M Sales, Euzenir Sarno, Mahesh Shah, Digafe Tsegaye, Diana N J Lockwood
Erythema nodosum leprosum (ENL) is a severe multisystem immune mediated complication of borderline lepromatous leprosy and lepromatous leprosy. ENL is associated with skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. The treatment of ENL requires immunosuppression, which is often required for prolonged periods of time and may lead to serious adverse effects. ENL and its treatment is associated with increased mortality and economic hardship. Improved, evidence-based treatments for ENL are needed; however, defining the severity of ENL and outcome measures for treatment studies is difficult because of the multiple organ systems involved...
2015: PLoS Neglected Tropical Diseases
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