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Financial toxicity

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https://www.readbyqxmd.com/read/29141397/supporting-low-income-cancer-patients-recommendations-for-the-public-financial-aid-program-in-the-republic-of-korea
#1
Hye Sook Min, Hyung Kook Yang, Keeho Park
Purpose: As the recent term of "financial toxicity" implies, cancer causes a treatment-related financial harm. Financial Aid Program for Cancer Patient (FAPCP) is a government's financial support for low-income patients in the Republic of Korea. This study aimed to describe FAPCP applicants' condition and to investigate factors influencing financial burden, which would provide the basis for implementing a strategy for FAPCP administration. Materials and Methods: The telephone survey results from 2,700 FAPCP participants were analyzed, including demographic, socioeconomic, and disease characteristics and experiences associated with financial burden and the actions or measures to cope with them...
November 15, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29124450/stepwise-strategy-for-monitoring-toxic-cyanobacterial-blooms-in-lentic-water-bodies
#2
Inês P E Macário, Bruno B Castro, Isabel M S Nunes, Cristina Pizarro, Carla Coelho, Fernando Gonçalves, Daniela R de Figueiredo
Climate change has been causing the increase in frequency, severity, and duration of harmful algal blooms, which makes the establishment of water management strategies indispensable. For cyanobacteria, several methods are currently used in monitoring programs. However, these methods are time-consuming and require specialists, and results are usually not provided within an adequate timeframe for taking timely mitigation actions. This work proposes a strategy for a faster, easier, and more cost-effective monitoring of cyanobacterial blooms, using a stepwise approach based on fluorometric determination of phycocyanin at an early stage...
November 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29124417/oncology-navigators-perceptions-of-cancer-related-financial-burden-and-financial-assistance-resources
#3
Jennifer C Spencer, Cleo A Samuel, Donald L Rosenstein, Katherine E Reeder-Hayes, Michelle L Manning, Jean B Sellers, Stephanie B Wheeler
INTRODUCTION: As the cost of cancer treatment continues to rise, many patients are faced with significant emotional and financial burden. Oncology navigators guide patients through many aspects of care and therefore may be especially aware of patients' financial distress. Our objective was to explore navigators' perception of their patients' financial burden and their role in addressing financial needs. MATERIALS AND METHODS: We conducted a real-time online survey of attendees at an oncology navigators' association conference...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29113839/addressing-financial-toxicity-the-role-of-the-urologist
#4
EDITORIAL
Matthew Mossanen, Angela B Smith
No abstract text is available yet for this article.
November 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29095527/clinical-guidance-for-radioiodine-refractory-differentiated-thyroid-cancer
#5
Matti L Gild, Duncan J Topliss, Diana Learoyd, Francis Parnis, Jeanne Tie, Brett Hughes, John P Walsh, Donald Sa McLeod, Roderick J Clifton-Bligh, Bruce G Robinson
Prognosis from differentiated thyroid cancer is worse when the disease becomes refractory to radioiodine. Until recently, treatment options have been limited to local therapies such as surgery and radiotherapy, but the recent availability of systemic therapies now provides some potential for disease control. Multi-targeted kinase inhibitors (TKIs) including lenvatinib and sorafenib have been shown to improve progression free survival in Phase III clinical trials, but are also associated with a spectrum of adverse effects...
November 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29081191/-analysis-on-tyrosine-kinase-inhibitor-discontinuation-in-patients-with-chronic-myeloid-leukemia-in-the-real-world-experience-from-single-center
#6
L Yu, Y Z Qin, Q Jiang
Objective: To explore status of tyrosine kinase inhibitor (TKI) discontinuation in patients with chronic myeloid leukemia (CML) in the chronic phase (CP) in the real world, to analyze causes, factors and outcomes associated with TKI discontinuation and the possibility of pursuit treatment-free remission (TFR) in China. Methods: From January 2013 to August 2016, data of CML-CP patients in Peking University People's Hospital which were not enrolled in clinical trials were retrospectively collected and analyzed...
September 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29079897/the-case-volume-issue-in-head-and-neck-oncology
#7
REVIEW
Salvatore Alfieri, Ester Orlandi, Paolo Bossi
In the past few years, several evidences reported better outcomes, in terms of reduced toxicities and longer survival, for head and neck cancer (HNC) patients when "regionalized," namely if they are managed at "high-volume" cancer referral centers (CRC). The benefit of case volume has been demonstrated in HNC patients primarily treated with surgery and in those receiving curative radiotherapy and chemotherapy. Many factors could explain these positive results: organization, facilities, processes of care, quality assurance programs, professional expertise, technology, and patient referral bias...
October 27, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29068247/australian-elapid-snake-envenomation-in-cats-clinical-priorities-and-approach
#8
Trudi J Mcalees, Linda A Abraham
Practical relevance: No fewer than 140 species of terrestrial snakes reside in Australia, 92 of which possess venom glands. With the exception of the brown tree snake, the venom-producing snakes belong to the family Elapidae. The venom of a number of elapid species is more toxic than that of the Indian cobra and eastern diamondback rattle snake, which has earned Australia its reputation for being home to the world's most venomous snakes. Clinical challenges: The diagnosis of elapid snake envenomation is not always easy...
November 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29025266/the-abcs-of-immunotherapy-for-adult-patients-with-b-cell-acute-lymphoblastic-leukemia
#9
Troy Z Horvat, Amanda N Seddon, Adebayo Ogunniyi, Amber C King, Larry W Buie, Ryan J Daley
OBJECTIVE: To review the pharmacology, efficacy, and safety of Food and Drug Administration approved and promising immunotherapy agents used in the treatment of acute lymphoblastic leukemia (ALL). DATA SOURCES: A literature search was performed of PubMed and MEDLINE databases (1950 to July 2017) and of abstracts from the American Society of Hematology and the American Society of Clinical Oncology. Searches were performed utilizing the following key terms: rituximab, blinatumomab, inotuzumab, ofatumumab, obinutuzumab, Blincyto, Rituxan, Gazyva, Arzerra, CAR T-cell, and chimeric antigen receptor (CAR)...
October 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28988744/management-of-endometriosis-toward-value-based-cost-effective-affordable-care
#10
REVIEW
Paolo Vercellini, Federica Facchin, Laura Buggio, Giussy Barbara, Nicola Berlanda, Maria Pina Frattaruolo, Edgardo Somigliana
Endometriosis management seems to be influenced by outcome-independent biomedical, pharmacological, and technological developments. The propensity towards doing more affects several aspects of care, sometimes translating into proposals that are not based on sound epidemiological principles and robust evidence. Different stakeholders share the interest for doing more testing and using novel and costly drugs or devices in patients with endometriosis. Although some women may benefit from such an approach, the majority do not, and some may be harmed...
October 5, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28962522/characterization-of-triptolide-induced-hepatotoxicity-by-imaging-and-transcriptomics-in-a-novel-zebrafish-model
#11
Adriaan D Bastiaan Vliegenthart, Chunmin Wei, Charlotte Buckley, Cécile Berends, Carmelita M J de Potter, Sarah Schneemann, Jorge Del Pozo, Carl Tucker, John J Mullins, David J Webb, James W Dear
Triptolide is a vine extract used in traditional Chinese medicines and associated with hepatotoxicity. In vitro data suggest that inhibition of RNA synthesis may be the mechanism of toxicity. For studying drug-induced liver injury the zebrafish has experimental, practical and financial advantages compared with rodents. The aim of this study was to explore the mechanism of triptolide toxicity using zebrafish as the model system. The effect of triptolide exposure on zebrafish larvae was determined with regard to mortality, histology, expression of liver specific microRNA-122 and liver volume...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28957637/financial-toxicity-a-common-but-rarely-discussed-treatment-side-effect
#12
Cara McDermott
No abstract text is available yet for this article.
September 28, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28949938/the-value-in-cancer-care-consortium-addressing-financial-toxicity
#13
Allen S Lichter
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28931096/-nutrition-therapy-of-cancer-patients
#14
József Lövey
The majority of cancer patients becomes malnourished during the course of their disease. Malnutrition deteriorates the efficiency of all kinds of oncologic interventions. As a consequence of it, treatment-related toxicity increases, hospital stay is lengthened, chances of cure and survival as well as the quality of life of the patients worsen. Nutritional status therefore influences all aspects of outcome of oncology care. In spite of this the use of nutritional therapy varies across health care providers but its application is far from being sufficient during active oncology interventions as well as rehabilitation and supportive care...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28925976/shiga-toxin-therapeutics-beyond-neutralization
#15
REVIEW
Gregory Hall, Shinichiro Kurosawa, Deborah J Stearns-Kurosawa
Ribotoxic Shiga toxins are the primary cause of hemolytic uremic syndrome (HUS) in patients infected with Shiga toxin-producing enterohemorrhagic Escherichia coli (STEC), a pathogen class responsible for epidemic outbreaks of gastrointestinal disease around the globe. HUS is a leading cause of pediatric renal failure in otherwise healthy children, resulting in a mortality rate of 10% and a chronic morbidity rate near 25%. There are currently no available therapeutics to prevent or treat HUS in STEC patients despite decades of work elucidating the mechanisms of Shiga toxicity in sensitive cells...
September 19, 2017: Toxins
https://www.readbyqxmd.com/read/28899853/the-potential-for-chemotherapy-free-strategies-in-mantle-cell-lymphoma
#16
REVIEW
Peter Martin, Jia Ruan, John P Leonard
Mantle cell lymphoma (MCL) may be 1 of the few cancers for which multiple chemotherapy and nonchemotherapy regimens are considered as standard. Despite the significant activity of chemotherapy in the first-line setting and beyond, its limitations are reflected in the relatively poor ultimate outcomes of patients with MCL treated in the real world. Patients with highly proliferative MCL and those with TP53 mutations tend to respond poorly despite intensive cytotoxic therapies. Patients with comorbidities and those who are geographically isolated may not have access to the regimens that may appear most promising in clinical trials...
October 26, 2017: Blood
https://www.readbyqxmd.com/read/28893720/the-case-for-universal-screening-of-private-well-water-quality-in-the-u-s-and-testing-requirements-to-achieve-it-evidence-from-arsenic
#17
Yan Zheng, Sara V Flanagan
BACKGROUND: The 1974 Safe Drinking Water Act (SDWA) regulates >170,000 public water systems to protect health, but not >13 million private wells. State and local government requirements for private well water testing are rare and inconsistent; the responsibility to ensure water safety remains with individual households. Over the last two decades, geogenic arsenic has emerged as a significant public health concern due to high prevalence in many rural American communities. OBJECTIVES: We build the case for universal screening of private well water quality around arsenic, the most toxic and widespread of common private water contaminants...
August 3, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28885879/infusion-room-based-transition-to-practice-model-for-teaching-cancer-systemic-therapy-management
#18
Jennifer M Duff, Merry-Jennifer Markham, Thomas J George, Julia L Close
PURPOSE: Oncology training requirements mandate that fellows demonstrate competence in delivery of cancer therapeutics, understand clinical indications for treatment, and manage toxicities by completion of training. An academic training environment may hinder fellows' engagement in prescribing, monitoring, and adjusting cancer therapy; thus, trainees may complete their fellowship with limited experience in developing such critical skills. To provide hands-on experience in cancer systemic therapy management, we created a novel infusion room-based rotation in the final year of training; here we report the structure, logistics, and evaluation of this innovative program...
November 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28847066/-reliability-and-validity-of-the-chinese-version-on-comprehensive-scores-for-financial-toxicity-based-on-the-patient-reported-outcome-measures
#19
H H Yu, X Bi, Y Y Liu
Objective: To evaluate the reliability and validity of the Chinese version on comprehensive scores for financial toxicity (COST), based on the patient-reported outcome measures. Methods: A total of 118 cancer patients were face-to-face interviewed by well-trained investigators. Cronbach's α and Pearson correlation coefficient were used to evaluate reliability. Content validity index (CVI) and exploratory factor analysis (EFA) were used to evaluate the content validity and construct validity, respectively. Results: The Cronbach's α coefficient appeared as 0...
August 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28840635/adaptive-phase-i-ii-clinical-trials-for-drug-combination-assessment-in-oncology-using-the-outcomes-of-each-cycle
#20
Shinjo Yada, Chikuma Hamada
Many new anticancer agents can be combined with existing drugs, as combining a number of drugs may be expected to have a better therapeutic effect than monotherapy owing to synergistic effects. Furthermore, to drive drug development and to reduce the associated cost, there has been a growing tendency to combine these as phase I/II trials. With respect to phase I/II oncology trials for the assessment of dose combinations, in the existing methodologies in which efficacy based on tumor response and safety based on toxicity are modeled as binary outcomes, it is not possible to enroll and treat the next cohort of patients unless the best overall response has been determined in the current cohort...
August 25, 2017: Pharmaceutical Statistics
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