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Financial toxicity

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https://www.readbyqxmd.com/read/28057183/immunoth%C3%A3-rapie-une-innovation-de-rupture-non-soutenable-%C3%A3-conomiquement
#1
Jean-Pierre Thierry
A NON-SUSTAINABLE BREAKTHROUGH?: The arrival of new immunotherapy anticancer drugs on the market marks a turning point. Their reference prices are fixed in the US and are positioned at the same level that the anticancer targeted therapies. They benefit from an accelerated approval process and often obtain the status of orphan drugs. The extensions of indications to many cancers and the likely combinations could significantly increase healthcare spending at a level that recently unveiled their non-sustainability, due to unrealistic prices approved by regulators...
November 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/28048407/th-d-brc-04-panel-member
#2
C Yu
: Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048287/th-d-brc-00-educational-point-counter-point-has-photon-rt-hit-the-limits
#3
Bulent Aydogan
: Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047641/th-d-brc-01-panel-member
#4
B Aydogan
: Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046989/th-d-brc-02-panel-member
#5
S Hahn
: Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046331/th-d-brc-03-panel-member
#6
H Paganetti
: Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034356/improving-cancer-care-for-children-in-the-developing-world-challenges-and-strategies
#7
Zakiya Al Lamki
Cancer is a global health problem particularly in developing countries where the burden of cancer is ever increasing and claiming the lives of about 100,000 children under the age of 15 years every year. Majority of these occur in the Low and Middle Income Countries (LMICs) where 90% of world children live. Contributing factors to this trend is the reduction of communicable diseases and emergence of new infections, improvement of nutrition and socio-economic conditions, industrialization and urbanization. However, due to its complexity, childhood cancer is given the least priority by the governments' funding...
December 30, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27997003/-unpleaseant-news
#8
Francesco Perrone, Ciro Gallo
An impressive amount of new drugs and new indications is arriving in the cancer arena. Financial affordability of so much innovation is difficult everywhere. In Europe, the access to new drugs is not uniform and particularly the patients of Eastern countries frequently cannot receive effective drugs. In the United States financial distress is acknowledged to be a side effect of new expensive drugs. However, we surprisingly found that financial problems are associated with worse cancer patients outcomes also in Italy, where a public health system exists and pays anticancer drugs...
December 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27982316/mobilization-of-hematopoietic-progenitor-cells-for-autologous-transportation-consensus-recommendations
#9
Fernando Barroso Duarte, Benedito de Pina Almeida Prado, Garles Miller Matias Vieira, Luciano J Costa
Selected patients with certain hematological malignancies and solid tumors have the potential to achieve long-term survival with autologous hematopoietic progenitor cell transplant. The collection of these cells in peripheral blood avoids multiple bone marrow aspirations, results in faster engraftment and allows treatment of patients with infection, fibrosis, or bone marrow hypocellularity. However, for the procedure to be successful, it is essential to mobilize a sufficient number of progenitor cells from the bone marrow into the blood circulation...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27960067/do-patients-and-oncologists-discuss-the-cost-of-cancer-treatment-an-observational-study-of-clinical-interactions-between-african-american-patients-and-their-oncologists
#10
Lauren M Hamel, Louis A Penner, Susan Eggly, Robert Chapman, Justin F Klamerus, Michael S Simon, Sarah C E Stanton, Terrance L Albrecht
PURPOSE: Financial toxicity negatively affects patients with cancer, especially racial/ethnic minorities. Patient-oncologist discussions about treatment-related costs may reduce financial toxicity by factoring costs into treatment decisions. This study investigated the frequency and nature of cost discussions during clinical interactions between African American patients and oncologists and examined whether cost discussions were affected by patient sociodemographic characteristics and social support, a known buffer to perceived financial stress...
December 13, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27957789/real-world-outcomes-of-treatment-for-acute-lymphoblastic-leukemia-during-adolescence-in-a-financially-restricted-environment-results-at-a-single-center-in-latin-america
#11
José C Jaime-Pérez, Raúl A Jiménez-Castillo, Mónica A Pinzón-Uresti, Olga G Cantú-Rodríguez, José L Herrera-Garza, Luis J Marfil-Rivera, David Gómez-Almaguer
OBJECTIVE: There is a paucity of the studies of adolescents with acute lymphoblastic leukemia (ALL). This is more noticeable in low- and middle-income countries. The international 5-year event-free survival (EFS) and overall survival (OS) for this age group is around 80%, with pediatric-inspired protocols offering better results. METHODS: A retrospective analysis of adolescents aged 16-20 diagnosed with ALL during the period 2004-2015 treated with a high-risk pediatric protocol at an academic center from a middle-income country was performed...
December 13, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27956296/postoperative-hemorrhagic-occlusive-retinal-vasculitis-associated-with-intracameral-vancomycin-prophylaxis-during%C3%A2-cataract-surgery
#12
Matthew A Miller, Lucas T Lenci, Chittaranjan V Reddy, Stephen R Russell
: We present the case of a 75-year-old man who had uneventful cataract surgery and administration of intracameral vancomycin for endophthalmitis prophylaxis, followed by the same procedure in the fellow eye 1 week later. The patient subsequently developed bilateral hemorrhagic occlusive retinal vasculitis, resulting in profound vision loss in both eyes. A second case of hemorrhagic occlusive retinal vasculitis previously reported from our institution is summarized. That case was characterized by a far milder course, with rapid resolution of vision loss...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27956287/toxic-anterior-segment-syndrome-caused-by-autoclave-reservoir-wall-biofilms-and-their-residual-toxins
#13
Andrew L Sorenson, Robert L Sorenson, David J Evans
PURPOSE: To identify etiology of toxic anterior segment syndrome (TASS) after uneventful phacoemulsification. SETTING: EyeMD Laser and Surgery Center, Oakland, California. DESIGN: Retrospective case series. METHODS: Patient charts with TASS were reviewed. Reservoirs of 2 autoclaves associated with these cases were cultured for bacterial contamination. Cultures were performed on 23 other autoclave reservoirs at surgery centers in the local area...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27936870/emerging-biomarkers-for-pd-1-pathway-cancer-therapy
#14
Joline Sj Lim, Raghav Sundar, Maxime Chénard-Poirier, Juanita Lopez, Timothy A Yap
The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-related toxicities and substantial financial burden. It is, therefore, critical to identify patients likely to benefit from such immunotherapies and develop strategies to differentiate responders from nonresponders early during treatment...
January 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27927156/financial-toxicity-in-clinical-care-today-a-menu-without-prices
#15
Sanchia Aranda, David Currow
No abstract text is available yet for this article.
December 12, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27927155/financial-toxicity-in-clinical-care-today-a-menu-without-prices
#16
Bogda Koczwara, Louisa Gordon, Ian N Olver
No abstract text is available yet for this article.
December 12, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27913491/prognostic-factors-in-follicular-lymphoma-new-tools-to-personalize-risk
#17
Carla Casulo
Follicular lymphoma (FL) is the most common indolent lymphoma, and it has a long median overall survival (OS). However, the recent discovery of clinical and biological prognostic biomarkers in FL is shedding light on FL heterogeneity and the need for a precise and risk-stratified individual approach at diagnosis and relapse. Many FL patients who are asymptomatic with indolent disease can be vulnerable to the toxicity, emotional distress, and financial burden of overtreatment. Yet a subset of FL patients develop chemoresistance to standard chemoimmunotherapy, experience transformation to aggressive lymphoma and rapid progression, and represent the population most in need of novel therapies and curative approaches...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27893021/mitigating-financial-toxicity-among-us-patients-with-cancer
#18
Jonas A de Souza, Rena M Conti
No abstract text is available yet for this article.
November 23, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27870563/economic-burden-of-chronic-lymphocytic-leukemia-in-the-era-of-oral-targeted-therapies-in-the-united-states
#19
Qiushi Chen, Nitin Jain, Turgay Ayer, William G Wierda, Christopher R Flowers, Susan M O'Brien, Michael J Keating, Hagop M Kantarjian, Jagpreet Chhatwal
Purpose Oral targeted therapies represent a significant advance for the treatment of patients with chronic lymphocytic leukemia (CLL); however, their high cost has raised concerns about affordability and the economic impact on society. Our objective was to project the future prevalence and cost burden of CLL in the era of oral targeted therapies in the United States. Methods We developed a simulation model that evaluated the evolving management of CLL from 2011 to 2025: chemoimmunotherapy (CIT) as the standard of care before 2014, oral targeted therapies for patients with del(17p) and relapsed CLL from 2014, and for first-line treatment from 2016 onward...
January 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27866392/drug-caused-deaths-in-australian-medical-practitioners-and-health-care-professionals
#20
Jennifer L Pilgrim, Rhyse Dorward, Olaf H Drummer
BACKGROUND AND AIMS: There are numerous factors putting health-care professionals (HCP) at a higher risk of substance abuse and premature death, including high-stress jobs, access to controlled substances, long hours of practice and constant contact with the critically ill. This study aimed to examine fatal drug toxicity in this high-risk cohort, in order to: (1) estimate the rate of drug-caused deaths of Australian HCPs; (2) describe the key characteristics of the cohort; and (3) examine the relationship between HCP occupation and drug type, or intent...
November 20, 2016: Addiction
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