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Financial toxicity

Lisbeth E Knudsen, Zorana J Andersen, Radim J Sram, Markéta Braun Kohlová, Eugen S Gurzau, Aleksandra Fucic, Laura Gribaldo, Pavel Rossner, Andrea Rossnerova, Vojtěch Máca, Iva Zvěřinová, Dagmar Gajdosova, Hanns Moshammer, Peter Rudnai, Milan Ščasný
In 2013-2015, a consortium of European scientists - NEWDANUBE - was established to prepare a birth cohort in the Danube region, including most of the countries with the highest air pollution in Europe, the area being one-fifth of the European Union's (EU's) territory, including 14 countries (nine EU member states), over 100 million inhabitants, with numerous challenges: big socioeconomic disparities, and a region-specific environmental pollution. The consortium reflects the EU Strategy for the Danube Region Strategy (2010), which identified 11 thematic Priority Areas - one of which is the environmental risks...
October 18, 2016: Reviews on Environmental Health
S F Huntington
No abstract text is available yet for this article.
October 13, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Patricia A Fleming, Shannon J Dundas, Yvonne Y W Lau, John R Pluske
Outdoor pig operations are an alternative to intensive systems of raising pigs; however for the majority of outdoor pork producers, issues of biosecurity and predation control require significant management and (or) capital investment. Identifying and quantifying predation risk in outdoor pork operations has rarely been done, but such data would be informative for these producers as part of their financial and logistical planning. We quantified potential impact of fox predation on piglets bred on an outdoor pork operation in south-western Australia...
October 8, 2016: Animals: An Open Access Journal From MDPI
Amit Roy, Pawinee Mahasittiwat, Ashley A Weiner, Steven R Hunt, Matthew G Mutch, Elisa H Birnbaum, Ira J Kodner, Thomas E Read, James W Fleshman, Jeffrey R Olsen, Robert J Myerson, Parag J Parikh
PURPOSE: Preoperative short-course radiation therapy (SCRT) has rarely been used for rectal cancer in the United States, although 2 randomized phase 3 trials demonstrate equivalence to conventional chemoradiation (CRT), and recent updates to national guidelines include this regimen as a treatment option. We sought to evaluate the efficacy and safety of preoperative SCRT followed by immediate surgery within 1 week to treat rectal cancer in the US setting. METHODS AND MATERIALS: All patients treated with preoperative SCRT (4 Gy × 5 fractions for total 20 Gy) followed by planned surgery within 1 week at our institution were retrospectively evaluated...
August 31, 2016: Practical Radiation Oncology
Jonas A de Souza, Bonnie J Yap, Kristen Wroblewski, Victoria Blinder, Fabiana S Araújo, Fay J Hlubocky, Lauren H Nicholas, Jeremy M O'Connor, Bruce Brockstein, Mark J Ratain, Christopher K Daugherty, David Cella
BACKGROUND: Cancer and its treatment lead to increased financial distress for patients. To the authors' knowledge, to date, no standardized patient-reported outcome measure has been validated to assess this distress. METHODS: Patients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recruited. Financial toxicity was measured by the COmprehensive Score for financial Toxicity (COST) measure. The authors collected data regarding patient characteristics, clinical trial participation, health care use, willingness to discuss costs, psychological distress (Brief Profile of Mood States [POMS]), and health-related quality of life (HRQOL) as measured by the Functional Assessment of Cancer Therapy: General (FACT-G) and the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaires...
October 7, 2016: Cancer
Samit Kumar Nandi, Samiran Bandyopadhyay, Piyali Das, Indranil Samanta, Prasenjit Mukherjee, Subhasis Roy, Biswanath Kundu
Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not only from therapeutic failure but also due to adverse side effects of antibiotics and financial loss due to additional stay at hospitals. A wide application of carrier systems, as a medium for local delivery of antibiotics, is being used experimentally and clinically for the treatment of osteomyelitis...
September 28, 2016: Biotechnology Advances
Faïza Bessaoud, Mattéa Orsini, François Iborra, Xavier Rebillard, Antoine Faix, Maryvonne Soulier, Jean-Pierre Daurès, Brigitte Trétarre
INTRODUCTION: An increasing number of patients with prostate cancer (PC) are diagnosed and treated. The aim of this study was to investigate urinary incontinence (UI) and sexual dysfunction (SD) two years after treatment for localized prostate cancer (PC). METHODS: This study followed all cases of localized PC diagnosed between 2008 and 2009 in men aged≤65years old and still alive two years after treatment. In total, 437 men were recruited. Data were collected using a standardized questionnaire and by cross-checking with data from the cancer registry...
September 29, 2016: Bulletin du Cancer
Antonio Ivan Lazzarino, Mark Hamer, David Gaze, Paul Collinson, Ann Rumley, Gordon Lowe, Andrew Steptoe
We have previously shown that there is a complex and dynamic biological interaction between acute mental stress and acute release of inflammatory factors into the blood stream in relation to heart disease. We now hypothesize that the presence of chronic psychosocial stress may modify the weight of single test results for inflammation as a predictor of heart disease. Using a cross-sectional design, 500 participants free from heart disease drawn from the Whitehall II study in UK in 2006-2008 were tested for plasma fibrinogen as an inflammatory factor, financial strain as a marker of chronic psychosocial stress, coronary calcification measured using computed tomography, and for plasma high-sensitivity cardiac troponin T (HS-CTnT) as a marker of cardiac risk...
September 20, 2016: Preventive Medicine
Wojciech Rogowski, Violetta Sulżyc-Bielicka
We still do not know whether the presently used protocol of the first-line palliative treatment of disseminated colorectal cancer (FOLFOX/FOLFIRI protocol) allows maximization of therapeutic response and minimization of side effects. No-one has verified whether continuation of the first-line chemotherapy despite the lack of progression is reflected by improved prognosis or significant risk of toxicity. This issue is of vital importance in the case of developing countries where targeted therapies are not available due to financial shortages...
2016: Contemporary Oncology Współczesna Onkologia
Pei-Yu Hsu, Sien-Hung Yang, Ngan-Ming Tsang, Kang-Hsing Fan, Chia-Hsun Hsieh, Jr-Rung Lin, Ji-Hong Hong, Yung-Chang Lin, Hsing-Yu Chen, Cheng-Tao Yang, Ching-Wei Yang, Jiun-Liang Chen
Xerostomia is one of the most common acute and late complications of radiotherapy for head and neck cancer, and it affects quality of life. We conducted a prospective study to evaluate the efficacy of traditional Chinese medicine (TCM) in toxicities and quality of life during radiotherapy. Head and neck cancer patients who were scheduled for radiotherapy were checked for inclusion/exclusion criteria before enrollment. Patients in the study group (inpatients) were hospitalized in a Chinese medicine ward and received concomitant TCM intervention during radiotherapy, while those in the control group (outpatients) received only conventional cancer treatments at the Western outpatient department...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Vanita Noronha, Anant Ramaswamy, Vijay M Patil, Amit Joshi, Anuradha Chougule, Subhadha Kane, Rajiv Kumar, Arvind Sahu, Vipul Doshi, Lingaraj Nayak, Abhishek Mahajan, Amit Janu, Kumar Prabhash
OBJECTIVES: To evaluate the performance and treatment profile of advanced EML4-ALK positive Non-small cell lung cancer (NSCLC) patients in a developing country with potentially restricted access to Crizotinib. MATERIALS AND METHODS: A retrospective analysis of advanced ALK positive NSCLC patients who were treated from June 2012 to September 2015 was conducted. The primary goal was to evaluate outcomes of advanced ALK positive NSCLC in our practice and examine the logistic constraints in procuring Crizotinib...
2016: PloS One
Terje Svingen, Niels Lund Hansen, Camilla Taxvig, Anne Marie Vinggaard, Udo Jensen, Peter Have Rasmussen
Mycotoxins are fungi-born metabolites that can contaminate foods through mould-infected crops. They are a significant food/feed-safety issue across the globe and represent a substantial financial burden for the world economy. Moreover, with a changing climate and fungal biota, there is now much discussion about emerging mycotoxins that are measurable at significant levels in crops world-wide. Unfortunately, we still know very little about the bioavailability and toxic potentials of many of these less characterized mycotoxins, including the large family of enniatins...
September 15, 2016: Environmental Toxicology
Ahmed A Hussein, Pamela Yango, Youseff Ezz, James F Smith, Nam D Tran
Infertility is a common disease affecting 10-15% of reproductive couples with significant psychological and financial impacts to both patients and society. Approximately 80 million people worldwide are infertile, with an increasing incidence of male infertility. Semen cryopreservation in adults is a proven method of fertility preservation for male patients undergoing gonadal toxic therapies. Unlike adults who can cryopreserve sperm at any time prior to gonadal toxic treatments, there are no effective fertility preservation options for children undergoing cancer treatment, a time when semen cryopreservation is not feasible...
December 2016: Minerva Ginecologica
Jihyun Emma Choi PhD, Sang-Bum Hong Md PhD, Kyung-Hyun Do Md PhD, Hwa Jung Kim Md PhD, Seockhoon Chung Md PhD, Eun Lee Md PhD, Jihyun Choi, Soo-Jong Hong
A large portion of the Korean population has been exposed to toxic humidifier disinfectants, and considering that the majority of the victims are infants, the magnitude of the damage is expected to be considerably larger than what has currently been revealed. The current victims are voicing problems caused by various diseases, including but not limited to lung, upper respiratory tract, cardiovascular, kidney, musculoskeletal, eye, and skin diseases, etc. However, there has been difficulty in gaining validation for these health problems and identifying causal relationships due to lack of evidence proving that toxic humidifier disinfectant is the specific causes of extrapulmonary diseases such as allergic rhinitis...
August 29, 2016: Environmental Health and Toxicology
Sunita M C De Sousa, Ian M Chapman, Henrik Falhammar, David J Torpy
Dopamine agonists are the first line of therapy for prolactinomas, with high rates of biochemical control and tumour shrinkage. Toxicity is considered to be low and manageable by switching of agents and dose reduction. Dopamine agonist-induced impulse control disorders are well described in the neurology setting, but further data are required regarding this toxicity in prolactinoma patients. We performed a multicenter retrospective cohort study of eight men with prolactinomas and associated central hypogonadism...
September 6, 2016: Endocrine
Halle Field, Ling Gao, Pooja Motwani, Henry K Wong
: Cutaneous T-cell lymphomas (CTCL) are a heterogeneous and relatively rare group of non-Hodgkin lymphomas arising from neoplastic skin-homing memory T cells. There is no known cure for CTCL, and current treatments focus on achieving and maintaining remission, controlling symptoms, limiting toxicities and maintaining or improving quality of life. Patients with CTCL often suffer from pruritus (itching), which can be debilitating and can have a significant impact on physical well-being and quality of life...
September 2, 2016: Dermatology and Therapy
Peter P Yu
Oncology patients often find themselves facing an incurable disease with limited treatment options and increasing patient fragility. The importance of patient preferences and values increases in shared decision making especially when the cost of cancer care is continuing its steep rise. As our understanding of cancer systems biology increases, we are justifiably optimistic about therapeutic improvements but recognize that this has complicated the traditional Food and Drug Administration approval of drug indications based on organ-specific cancer for a particular drug...
July 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
A J Lomax, J Beith, V Bhadri, M Boyer, P Grimison, L G Horvath, S Kao, M Tattersall, D Thomas, C McNeil
BACKGROUND: Immunotherapy agents show anti-cancer activity in several solid cancers. Efficacy in non-melanoma solid tumours for non-approved indications is unknown. METHOD: Retrospective review describing outcomes and toxicity of self-funded pembrolizumab in patients with non-melanoma solid cancers at Chris O'Brien Lifehouse. RESULTS: From April 2015 to December 2015, 21 patients received/planned to receive self-funded pembrolizumab. Median age was 50 (16-76), 28% and 10% had an ECOG of 2, and 3-4 respectively...
August 24, 2016: Internal Medicine Journal
Christina Ramsenthaler, Pauline Kane, Wei Gao, Richard J Siegert, Polly M Edmonds, Stephen A Schey, Irene J Higginson
OBJECTIVES: Multiple myeloma (MM) is an incurable haematological disease. Due to novel agents, overall survival has improved in this group, yet there are no systematic reviews to understand the symptom profiles resulting from disease and treatment-related toxicities. We aimed to synthesise data on the prevalence of symptoms in patients with MM. METHODS: A systematic database and grey literature search were conducted in six databases. Random-effects meta-analysis with inverse variance weighting to pool prevalence data was performed...
November 2016: European Journal of Haematology
Marcel Y Avila, Mauricio Narvaez, Juan P Castañeda
PURPOSE: To evaluate the effect of genipin, a natural crosslinking agent, in rabbit eyes. SETTING: Department of Ophthalmology, Universidad Nacional de Colombia Centro de Tecnologia Oftalmica, Bogotá, Colombia. DESIGN: Experimental study. METHODS: Ex vivo rabbit eyes (16; 8 rabbits) were treated with genipin 1.00%, 0.50%, and 0.25% for 5 minutes with a vacuum device to increase corneal permeability. Penetration was evaluated using Scheimpflug pachymetry (Pentacam)...
July 2016: Journal of Cataract and Refractive Surgery
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