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Financial toxicity

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https://www.readbyqxmd.com/read/28469333/treatment-challenges-and-survival-analysis-of-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-in-real-world
#1
Praveen Adusumilli, Meher Lakshmi Konatam, Sadashivudu Gundeti, Stalin Bala, Lakshmi Srinivas Maddali
CONTEXT: Advent of trastuzumab has brought tremendous changes in the survival of human epidermal growth factor receptor 2 (Her2)-positive breast cancer patients. Despite the availability of the drug, it is still out of reach for many patients. There is very limited real world data regarding treatment challenges and survival analysis of these patients. AIMS AND OBJECTIVES: Primary objective is disease-free survival (DFS) and secondary objective is overall survival (OS) and toxicity profile...
January 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28435252/polyphenol-nanoformulations-for-cancer-therapy-experimental-evidence-and-clinical-perspective
#2
REVIEW
Yasamin Davatgaran-Taghipour, Salar Masoomzadeh, Mohammad Hosein Farzaei, Roodabeh Bahramsoltani, Zahra Karimi-Soureh, Roja Rahimi, Mohammad Abdollahi
Cancer is defined as the abnormal cell growth that can cause life-threatening malignancies with high financial costs for patients as well as the health care system. Natural polyphenols have long been used for the prevention and treatment of several disorders due to their antioxidant, anti-inflammatory, cytotoxic, antineoplastic, and immunomodulatory effects discussed in the literature; thus, these phytochemicals are potentially able to act as chemopreventive and chemotherapeutic agents in different types of cancer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28432099/acute-hepatopancreatic-necrosis-disease-ahpnd-causing-vibrio-parahaemolyticus-strains-maintain-an-antibacterial-type-vi-secretion-system-with-versatile-effector-repertoires
#3
Peng Li, Lisa N Kinch, Ann Ray, Ankur B Dalia, Qian Cong, Linda M Nunan, Andrew Camilli, Nick V Grishin, Dor Salomon, Kim Orth
Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease that has severely damaged the global shrimp industry. AHPND is caused by toxic strains of Vibrio parahaemolyticus (V. parahaemolyticus) that have acquired a "selfish plasmid" encoding the deadly binary toxins PirA(vp)/PirB(vp) To better understand the repertoire of virulence factors in AHPND-causing V. parahaemolyticus, we conducted a comparative analysis using genome sequences of the clinical strain RIMD2210633, environmental non-AHPND and toxic AHPND isolates of V...
April 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28428282/whither-radioimmunotherapy-to-be-or-not-to-be
#4
Damian J Green, Oliver W Press
Therapy of cancer with radiolabeled monoclonal antibodies has produced impressive results in preclinical experiments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphomas. Two "first-generation," directly radiolabeled anti-CD20 antibodies, (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan, were FDA-approved more than a decade ago but have been little utilized because of a variety of medical, financial, and logistic obstacles. Newer technologies employing multistep "pretargeting" methods, particularly those utilizing bispecific antibodies, have greatly enhanced the therapeutic efficacy of radioimmunotherapy and diminished its toxicities...
May 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28421162/r-ideal-a-framework-for-systematic-clinical-evaluation-of-technical-innovations-in-radiation-oncology
#5
Helena M Verkooijen, Linda G W Kerkmeijer, Clifton D Fuller, Robbert Huddart, Corinne Faivre-Finn, Marcel Verheij, Stella Mook, Arjun Sahgal, Emma Hall, Chris Schultz
The pace of innovation in radiation oncology is high and the window of opportunity for evaluation narrow. Financial incentives, industry pressure, and patients' demand for high-tech treatments have led to widespread implementation of innovations before, or even without, robust evidence of improved outcomes has been generated. The standard phase I-IV framework for drug evaluation is not the most efficient and desirable framework for assessment of technological innovations. In order to provide a standard assessment methodology for clinical evaluation of innovations in radiotherapy, we adapted the surgical IDEAL framework to fit the radiation oncology setting...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28408974/bringing-a-genomic-perspective-to-the-safety-of-drug-treatment-in-oncology
#6
REVIEW
Federico Innocenti
This article describes the clinical relevance of toxicity of therapies administered to patients with cancer, putting the patient, rather than disease, at the center of the evaluation of safety of anti-cancer therapy. Hence, the implications of adverse events are described from the patient perspective, focusing on the impact of patient safety on quality of life and efficacy of treatment. Issues revolving around other types of safety, such as financial toxicity, are also discussed. The role played by genetics in the assessment of a patient's risk of adverse events is also discussed, both in relation to the potential of genomic research and in the context of current tools of fruition in clinical care...
2017: F1000Research
https://www.readbyqxmd.com/read/28403082/metronomic-oral-cyclosphosphamide-as-third-line-systemic-treatment-or-beyond-in-patients-with-inoperable-locoregionally-advanced-recurrent-or-metastatic-nasopharyngeal-carcinoma
#7
Victor H F Lee, Dora L W Kwong, Ka-On Lam, Yu-Ching Lai, Yun Li, Chi-Chung Tong, Patty P Y Ho, Wing-Lok Chan, Lai-San Wong, Dennis K C Leung, Sum-Yin Chan, Fong-Ting Chan, To-Wai Leung, Anne W M Lee
There is no standard third-line or further systemic treatment for patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma (NPC). Metronomic oral cyclophosphamide provides an acceptable and cheap option for these heavily pretreated patients who had limited choices. We conducted a prospective phase II single-arm open-label study of metronomic oral cyclophosphamide. Patients with locoregionally advanced recurrent inoperable (rT3/T4, rN2-N3b) or metastatic (rM1) NPC who had Eastern Cooperative Oncology Group (ECOG) performance status (PS) (0-2) and had progressed after at least 2 lines of palliative systemic chemotherapy were eligible...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28386297/low-value-practices-in-oncology-contributing-to-financial-toxicity
#8
Bishal Gyawali
Financial toxicity of cancer treatment is now a well-recognised problem in cancer medicine leading to patient bankruptcy and even poor survival, including in high-income countries and countries with public health care systems. Many oncologists, despite acknowledging the severity of financial toxicity as a problem, resign the responsibility of reducing the costs of cancer treatment to the government, industry, and oncology societies. However, an oncologist can play an important role in reducing the costs of cancer treatment because all cancer treatment decisions are made between the oncologist and the patient...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28384119/status-of-water-pollution-in-relation-to-industrialization-in-rajasthan
#9
Ritu Singh Rajput, Sonali Pandey, Seema Bhadauria
India is a large and densely populated country; its economy is largely agricultural. Making the best use of the country's manpower has always posed a challenge. Industrialization could become a dominant component of the economy and displace agriculture. Traditional livelihoods of occupational groups are threatened by the practice of disposing untreated industrial waste into rivers and bodies of water. These uncontrolled disposals impact local natural resources with negative long-term effects. Industrialization is the development of intellectual and financial trade that changes a predominantly rustic culture into a modern one...
April 6, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28357804/airborne-trace-elements-near-a-petrochemical-industrial-complex-in-thailand-assessed-by-the-lichen-parmotrema-tinctorum-despr-ex-nyl-hale
#10
Chaiwat Boonpeng, Wetchasart Polyiam, Chutima Sriviboon, Duangkamon Sangiamdee, Santi Watthana, Pier Luigi Nimis, Kansri Boonpragob
Several trace elements discharged by the petrochemical industry are toxic to humans and the ecosystem. In this study, we assessed airborne trace elements in the vicinity of the Map Ta Phut petrochemical industrial complex in Thailand by transplanting the lichen Parmotrema tinctorum to eight industrial, two rural, and one clean air sites between October 2013 and June 2014. After 242 days, the concentrations of As, Cd, Co, Cr, Cu, Hg, Mo, Ni, Pb, Sb, Ti, V, and Zn in lichens at most industrial sites were higher than those at the rural and the control sites; in particular, As, Cu, Mo, Sb, V, and Zn were significantly higher than at the control site (p < 0...
May 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28319712/toxic-compounds-biodegradation-and-toxicity-of-high-strength-wastewater-treated-under-elevated-nitrogen-concentration-in-the-activated-sludge-and-membrane-bioreactor-systems
#11
Jarungwit Boonnorat, Nimaradee Boonapatcharoen, Pradthana Prachanurak, Ryo Honda, Supaporn Phanwilai
This research has assessed the removal efficiencies of toxic compounds in the high strength wastewater (the leachate and agriculture wastewater mixture) using the activated sludge (AS) and membrane bioreactor (MBR) technologies under two carbon to nitrogen (C/N) ratios (C/N 14 and 6) and two toxic compounds concentrations (8-396μg/L and 1000μg/L). In addition, the toxicity evaluations of the AS and MBR effluents to the aquatic environment were undertaken at five effluent dilution ratios (10, 20, 30, 50 and 70% v/v)...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28294164/the-highly-synergistic-broad-spectrum-antibacterial-activity-of-organic-acids-and-transition-metals
#12
Daniel Zhitnitsky, Jessica Rose, Oded Lewinson
For millennia, transition metals have been exploited to inhibit bacterial growth. We report here the potentiation of the anti-bacterial activity of transition metals by organic acids. Strong synergy between low, non-toxic concentrations of transition metals and organic acids was observed with up to ~1000-fold higher inhibitory effect on bacterial growth. We show that organic acids shuttle transition metals through the permeability barrier of the bacterial membrane, leading to increased influx of transition metals into bacterial cells...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28271997/a-retrospective-study-of-clinical-profile-and-long-term-outcome-to-imatinib-mesylate-alone-in-childhood-chronic-myeloid-leukemia-in-chronic-phase
#13
(no author information available yet)
OBJECTIVE: Chronic myeloid leukemia (CML) is relatively rare malignancy in childhood. There are limited studies of use of Imatinib Mesylate (IM) alone in management of CML in this age group. METHOD: We retrospectively analyzed the outcome of 30 consecutive children with CML chronic phase treated with IM alone. RESULTS: The median age at the time of diagnosis was 11 years with male preponderance. Asthenia and abdominal discomfort due to splenomegaly were the most common presenting features and splenomegaly a dominant sign...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28247313/electronic-patient-reported-outcomes-and-toxicities-during-radiotherapy-for-head-and-neck-cancer
#14
Joshua R Niska, Michele Y Halyard, Angelina D Tan, Pamela J Atherton, Samir H Patel, Jeff A Sloan
PURPOSE: To characterize quality of life (QOL) using real-time, electronic patient-reported outcomes (ePROs) and to evaluate adverse events (AEs) and supportive care during head-and-neck radiotherapy (RT) and concurrent chemoradiotherapy (CCRT). METHODS: Sixty-five patients undergoing head-and-neck RT completed electronic, real-time, 12-item linear analog self-assessments (LASA) at baseline, before biweekly appointments, and at the last week of RT. Changes in QOL domains between time points were calculated...
February 28, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28218808/financial-toxicity-in-cancer-care-edging-toward-solutions
#15
EDITORIAL
Daniel A Goldstein
No abstract text is available yet for this article.
February 20, 2017: Cancer
https://www.readbyqxmd.com/read/28167570/financial-toxicity-and-societal-costs-of-cancer-care-distinct-problems-require-distinct-solutions
#16
Jeffrey Peppercorn
No abstract text is available yet for this article.
February 2017: Oncologist
https://www.readbyqxmd.com/read/28156544/equity-in-patient-provider-communication-regarding-treatment-related-symptoms-and-health-related-quality-of-life-hrqol-among-breast-cancer-survivors
#17
Jennifer Schaal, Linda Robertson, Eugenia Eng, Jemeia G Kollie, Christina Yongue, Karen Foley, Beth Smith, Mellissa K Yee, Kristin Black, Katrina Ellis, Lucretia Hoffman, Alexandra Lightfoot, Claire Morse, Neda Padilla, Sam Cykert
127 Background: Compared with white breast cancer patients, black patients more often report inadequate symptom control and decrements in health-related quality of life (HRQOL). Racial differences in patient-provider communication (PPC) are well-documented and linked to worse health outcomes for minorities; however, less is known about inequities in symptom and HRQOL discussions among cancer patients and providers. As part of an NCI-funded systems change intervention to improve racial equity in treatment completion among Black and White cancer patients, we assessed racial differences in PPC regarding treatment-related symptoms, HRQOL issues (e...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156492/food-as-medicine-a-randomized-controlled-trial-rct-of-home-delivered-medically-tailored-meals-hdmtm-on-quality-of-life-qol-in-metastatic-lung-and-non-colorectal-gi-cancer-patients
#18
Raymond Mailhot Vega, Lisa Zullig, Alissa Wassung, Dorella Walters, Noah Berland, Kevin Lee Du, Jiyoung Ahn, Cynthia G Leichman, Deirdre Jill Cohen, Ping Gu, Abraham Chachoua, Lawrence P Leichman, Karen Pearl, Peter B Schiff
155 Background: Malnutrition incidence in cancer approaches 85%, disproportionately burdening those with lung, GI, and advanced stage cancers. Malnourished patients have impaired chemotherapy response, shorter survival, longer hospital stays, and decreased QoL. Home delivered meals are nutritional interventions that improve patient well-being, nutrition, and lower healthcare costs in the elderly but have not been studied as an intervention in cancer patients. HDMTM are nutritionist prescribed home delivered meals tailored to patient's symptoms, co-morbidities, and health needs...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156483/impact-of-financial-burden-on-information-and-opportunity-for-cancer-ca-patients-pts-participation-par-in-clinical-trials-cts
#19
Dana Dornsife
166 Background: The degree to which cancer caused financial problems may influence ca pts par in cts and negatively impact quality of life (QoL). Financial burden of cts par, may include finding an appropriate trial, traveling to the trial site, paying for travel, lodging and some medical expenses. The Lazarex Cancer Foundation (LCF) was founded in 2006 with mission to improve care, giving hope, dignity, and life to advanced ca pts by providing assistance with options and costs to cts par, community outreach, and education...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156439/are-patients-with-cancer-concerned-about-burdening-their-families
#20
Kelly Choi, Ruth Pe Benito, Victoria DeVincenzo, Emily Sassano, Brooke Gruman, Katherine DeMarco, Jose Contreras, Kathryn Tanenbaum, Jennifer Covington, Dhakshila Paramanathan, Stuart L Goldberg
86 Background: A diagnosis of advanced cancer frequently thrusts family members into the role of caregiver. Although caregiver burdens have been well documented, less is known about the level of concern borne by the patient (pt) with cancer in placing a family member in this role, known as self-perceived burden (SPB). METHODS: As part of the larger "Living with Cancer" project we prospectively surveyed 1307 pts with advanced malignancies receiving treatment with non-curative intent at 17 New Jersey cancer programs within the Regional Cancer Care Associates network between Sept 2015 and Apr 2016...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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