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https://www.readbyqxmd.com/read/27913491/prognostic-factors-in-follicular-lymphoma-new-tools-to-personalize-risk
#1
Carla Casulo
Follicular lymphoma (FL) is the most common indolent lymphoma, and it has a long median overall survival (OS). However, the recent discovery of clinical and biological prognostic biomarkers in FL is shedding light on FL heterogeneity and the need for a precise and risk-stratified individual approach at diagnosis and relapse. Many FL patients who are asymptomatic with indolent disease can be vulnerable to the toxicity, emotional distress, and financial burden of overtreatment. Yet a subset of FL patients develop chemoresistance to standard chemoimmunotherapy, experience transformation to aggressive lymphoma and rapid progression, and represent the population most in need of novel therapies and curative approaches...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27893021/mitigating-financial-toxicity-among-us-patients-with-cancer
#2
Jonas A de Souza, Rena M Conti
No abstract text is available yet for this article.
November 23, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27870563/economic-burden-of-chronic-lymphocytic-leukemia-in-the-era-of-oral-targeted-therapies-in-the-united-states
#3
Qiushi Chen, Nitin Jain, Turgay Ayer, William G Wierda, Christopher R Flowers, Susan M O'Brien, Michael J Keating, Hagop M Kantarjian, Jagpreet Chhatwal
Purpose Oral targeted therapies represent a significant advance for the treatment of patients with chronic lymphocytic leukemia (CLL); however, their high cost has raised concerns about affordability and the economic impact on society. Our objective was to project the future prevalence and cost burden of CLL in the era of oral targeted therapies in the United States. Methods We developed a simulation model that evaluated the evolving management of CLL from 2011 to 2025: chemoimmunotherapy (CIT) as the standard of care before 2014, oral targeted therapies for patients with del(17p) and relapsed CLL from 2014, and for first-line treatment from 2016 onward...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27866392/drug-caused-deaths-in-australian-medical-practitioners-and-health-care-professionals
#4
Jennifer L Pilgrim, Rhyse Dorward, Olaf H Drummer
BACKGROUND AND AIMS: There are numerous factors putting health-care professionals (HCP) at a higher risk of substance abuse and premature death, including high-stress jobs, access to controlled substances, long hours of practice and constant contact with the critically ill. This study aimed to examine fatal drug toxicity in this high-risk cohort, in order to: (1) estimate the rate of drug-caused deaths of Australian HCPs; (2) describe the key characteristics of the cohort; and (3) examine the relationship between HCP occupation and drug type, or intent...
November 20, 2016: Addiction
https://www.readbyqxmd.com/read/27799013/ecotoxicological-assessment-of-dewatered-drinking-water-treatment-residue-for-environmental-recycling
#5
Nannan Yuan, Changhui Wang, Laura A Wendling, Yuansheng Pei
Drinking water treatment residue (DWTR) is commonly regarded as a waste product of drinking water treatment plant, which is disposed to sewer or to landfill, with associated financial and environmental costs. Fortunately, the beneficial recycle of DWTR in environmental remediation has been demonstrated in many reports. However, the lack of information concerning the potential toxicity of dewatered DWTR hinders its widespread use in environmental applications. The present study examined the ecotoxicity of dewatered aluminum (Al) and iron (Fe) DWTR leachates to a green alga, Chlorella vulgaris, systematically...
October 31, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27798816/a-systematic-review-of-financial-toxicity-among-cancer-survivors-we-can-t-pay-the-co-pay
#6
REVIEW
Louisa G Gordon, Katharina M D Merollini, Anthony Lowe, Raymond J Chan
OBJECTIVE: To determine the extent of financial toxicity (FT) among cancer survivors, identify the determinants and how FT is measured. METHODS: A systematic review was performed in MEDLINE, CINAHL and PsycINFO, using relevant terminology and included articles published from 1 January, 2013 to 30 June, 2016. We included observational studies where the primary outcomes included FT and study samples were greater than 200. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed...
October 31, 2016: Patient
https://www.readbyqxmd.com/read/27789469/the-association-of-financial-difficulties-with-clinical-outcomes-in-cancer-patients-secondary-analysis-of-16-academic-prospective-clinical-trials-conducted-in-italy
#7
F Perrone, C Jommi, M Di Maio, A Gimigliano, C Gridelli, S Pignata, F Ciardiello, F Nuzzo, A de Matteis, L Del Mastro, J Bryce, G Daniele, A Morabito, M C Piccirillo, G Rocco, L Guizzaro, C Gallo
BACKGROUND: Cancer may cause financial difficulties, but its impact in countries with public health systems is unknown. We evaluated the association of financial difficulties with clinical outcomes of cancer patients enrolled in academic clinical trials performed within the Italian public health system. PATIENTS AND METHODS: Data were pooled from 16 prospective multicentre trials in lung, breast or ovarian cancer, using the EORTC quality of life (QOL) C30 questionnaire...
October 26, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27754971/perinatal-health-in-the-danube-region-new-birth-cohort-justified
#8
Lisbeth E Knudsen, Zorana J Andersen, Radim J Sram, Markéta Braun Kohlová, Eugen S Gurzau, Aleksandra Fucic, Laura Gribaldo, Pavel Rossner, Andrea Rossnerova, Vojtěch Máca, Iva Zvěřinová, Dagmar Gajdosova, Hanns Moshammer, Peter Rudnai, Milan Ščasný
In 2013-2015, a consortium of European scientists - NEWDANUBE - was established to prepare a birth cohort in the Danube region, including most of the countries with the highest air pollution in Europe, the area being one-fifth of the European Union's (EU's) territory, including 14 countries (nine EU member states), over 100 million inhabitants, with numerous challenges: big socioeconomic disparities, and a region-specific environmental pollution. The consortium reflects the EU Strategy for the Danube Region Strategy (2010), which identified 11 thematic Priority Areas - one of which is the environmental risks...
October 18, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27742653/cancer-related-financial-toxicity-beyond-the-realm-of-drug-pricing-and-out-of-pocket-costs
#9
S F Huntington
No abstract text is available yet for this article.
October 13, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27740601/predation-by-red-foxes-vulpes-vulpes-at-an-outdoor-piggery
#10
Patricia A Fleming, Shannon J Dundas, Yvonne Y W Lau, John R Pluske
Outdoor pig operations are an alternative to intensive systems of raising pigs; however for the majority of outdoor pork producers, issues of biosecurity and predation control require significant management and (or) capital investment. Identifying and quantifying predation risk in outdoor pork operations has rarely been done, but such data would be informative for these producers as part of their financial and logistical planning. We quantified potential impact of fox predation on piglets bred on an outdoor pork operation in south-western Australia...
October 8, 2016: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/27720702/preoperative-short-course-radiation-therapy-for-rectal-cancer-provides-excellent-disease-control-and-toxicity-results-from-a-single-us-institution
#11
Amit Roy, Pawinee Mahasittiwat, Ashley A Weiner, Steven R Hunt, Matthew G Mutch, Elisa H Birnbaum, Ira J Kodner, Thomas E Read, James W Fleshman, Jeffrey R Olsen, Robert J Myerson, Parag J Parikh
PURPOSE: Preoperative short-course radiation therapy (SCRT) has rarely been used for rectal cancer in the United States, although 2 randomized phase 3 trials demonstrate equivalence to conventional chemoradiation (CRT), and recent updates to national guidelines include this regimen as a treatment option. We sought to evaluate the efficacy and safety of preoperative SCRT followed by immediate surgery within 1 week to treat rectal cancer in the US setting. METHODS AND MATERIALS: All patients treated with preoperative SCRT (4 Gy × 5 fractions for total 20 Gy) followed by planned surgery within 1 week at our institution were retrospectively evaluated...
August 31, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27716900/measuring-financial-toxicity-as-a-clinically-relevant-patient-reported-outcome-the-validation-of-the-comprehensive-score-for-financial-toxicity
#12
Jonas A de Souza, Bonnie J Yap, Kristen Wroblewski, Victoria Blinder, Fabiana S Araújo, Fay J Hlubocky, Lauren H Nicholas, Jeremy M O'Connor, Bruce Brockstein, Mark J Ratain, Christopher K Daugherty, David Cella
BACKGROUND: Cancer and its treatment lead to increased financial distress for patients. To the authors' knowledge, to date, no standardized patient-reported outcome measure has been validated to assess this distress. METHODS: Patients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recruited. Financial toxicity was measured by the COmprehensive Score for financial Toxicity (COST) measure. The authors collected data regarding patient characteristics, clinical trial participation, health care use, willingness to discuss costs, psychological distress (Brief Profile of Mood States [POMS]), and health-related quality of life (HRQOL) as measured by the Functional Assessment of Cancer Therapy: General (FACT-G) and the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaires...
October 7, 2016: Cancer
https://www.readbyqxmd.com/read/27693717/understanding-osteomyelitis-and-its-treatment-through-local-drug-delivery-system
#13
Samit Kumar Nandi, Samiran Bandyopadhyay, Piyali Das, Indranil Samanta, Prasenjit Mukherjee, Subhasis Roy, Biswanath Kundu
Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not only from therapeutic failure but also due to adverse side effects of antibiotics and financial loss due to additional stay at hospitals. A wide application of carrier systems, as a medium for local delivery of antibiotics, is being used experimentally and clinically for the treatment of osteomyelitis...
September 28, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27692730/-urinary-incontinence-and-sexual-dysfunction-after-treatment-of-localized-prostate-cancer-results-from-a-population-aged-less-than-65years-old
#14
Faïza Bessaoud, Mattéa Orsini, François Iborra, Xavier Rebillard, Antoine Faix, Maryvonne Soulier, Jean-Pierre Daurès, Brigitte Trétarre
INTRODUCTION: An increasing number of patients with prostate cancer (PC) are diagnosed and treated. The aim of this study was to investigate urinary incontinence (UI) and sexual dysfunction (SD) two years after treatment for localized prostate cancer (PC). METHODS: This study followed all cases of localized PC diagnosed between 2008 and 2009 in men aged≤65years old and still alive two years after treatment. In total, 437 men were recruited. Data were collected using a standardized questionnaire and by cross-checking with data from the cancer registry...
September 29, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27663429/the-interaction-between-systemic-inflammation-and-psychosocial-stress-in-the-association-with-cardiac-troponin-elevation-a-new-approach-to-risk-assessment-and-disease-prevention
#15
Antonio Ivan Lazzarino, Mark Hamer, David Gaze, Paul Collinson, Ann Rumley, Gordon Lowe, Andrew Steptoe
We have previously shown that there is a complex and dynamic biological interaction between acute mental stress and acute release of inflammatory factors into the blood stream in relation to heart disease. We now hypothesize that the presence of chronic psychosocial stress may modify the weight of single test results for inflammation as a predictor of heart disease. Using a cross-sectional design, 500 participants free from heart disease drawn from the Whitehall II study in UK in 2006-2008 were tested for plasma fibrinogen as an inflammatory factor, financial strain as a marker of chronic psychosocial stress, coronary calcification measured using computed tomography, and for plasma high-sensitivity cardiac troponin T (HS-CTnT) as a marker of cardiac risk...
December 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27647984/optimal-duration-of-a-first-line-palliative-chemotherapy-in-disseminated-colorectal-cancer-a-review-of-the-literature-from-a-developing-country-perspective
#16
REVIEW
Wojciech Rogowski, Violetta Sulżyc-Bielicka
We still do not know whether the presently used protocol of the first-line palliative treatment of disseminated colorectal cancer (FOLFOX/FOLFIRI protocol) allows maximization of therapeutic response and minimization of side effects. No-one has verified whether continuation of the first-line chemotherapy despite the lack of progression is reflected by improved prognosis or significant risk of toxicity. This issue is of vital importance in the case of developing countries where targeted therapies are not available due to financial shortages...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27642359/efficacy-of-traditional-chinese-medicine-in-xerostomia-and-quality-of-life-during-radiotherapy-for-head-and-neck-cancer-a-prospective-pilot-study
#17
Pei-Yu Hsu, Sien-Hung Yang, Ngan-Ming Tsang, Kang-Hsing Fan, Chia-Hsun Hsieh, Jr-Rung Lin, Ji-Hong Hong, Yung-Chang Lin, Hsing-Yu Chen, Cheng-Tao Yang, Ching-Wei Yang, Jiun-Liang Chen
Xerostomia is one of the most common acute and late complications of radiotherapy for head and neck cancer, and it affects quality of life. We conducted a prospective study to evaluate the efficacy of traditional Chinese medicine (TCM) in toxicities and quality of life during radiotherapy. Head and neck cancer patients who were scheduled for radiotherapy were checked for inclusion/exclusion criteria before enrollment. Patients in the study group (inpatients) were hospitalized in a Chinese medicine ward and received concomitant TCM intervention during radiotherapy, while those in the control group (outpatients) received only conventional cancer treatments at the Western outpatient department...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27637025/alk-positive-lung-cancer-clinical-profile-practice-and-outcomes-in-a-developing-country
#18
Vanita Noronha, Anant Ramaswamy, Vijay M Patil, Amit Joshi, Anuradha Chougule, Subhadha Kane, Rajiv Kumar, Arvind Sahu, Vipul Doshi, Lingaraj Nayak, Abhishek Mahajan, Amit Janu, Kumar Prabhash
OBJECTIVES: To evaluate the performance and treatment profile of advanced EML4-ALK positive Non-small cell lung cancer (NSCLC) patients in a developing country with potentially restricted access to Crizotinib. MATERIALS AND METHODS: A retrospective analysis of advanced ALK positive NSCLC patients who were treated from June 2012 to September 2015 was conducted. The primary goal was to evaluate outcomes of advanced ALK positive NSCLC in our practice and examine the logistic constraints in procuring Crizotinib...
2016: PloS One
https://www.readbyqxmd.com/read/27628925/enniatin-b-and-beauvericin-are-common-in-danish-cereals-and-show-high-hepatotoxicity-on-a-high-content-imaging-platform
#19
Terje Svingen, Niels Lund Hansen, Camilla Taxvig, Anne Marie Vinggaard, Udo Jensen, Peter Have Rasmussen
Mycotoxins are fungi-born metabolites that can contaminate foods through mould-infected crops. They are a significant food/feed-safety issue across the globe and represent a substantial financial burden for the world economy. Moreover, with a changing climate and fungal biota, there is now much discussion about emerging mycotoxins that are measurable at significant levels in crops world-wide. Unfortunately, we still know very little about the bioavailability and toxic potentials of many of these less characterized mycotoxins, including the large family of enniatins...
September 15, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27619261/fertility-preservation-options-for-prepubertal-boys-facing-gonadotoxic-therapies
#20
Ahmed A Hussein, Pamela Yango, Youseff Ezz, James F Smith, Nam D Tran
Infertility is a common disease affecting 10-15% of reproductive couples with significant psychological and financial impacts to both patients and society. Approximately 80 million people worldwide are infertile, with an increasing incidence of male infertility. Semen cryopreservation in adults is a proven method of fertility preservation for male patients undergoing gonadal toxic therapies. Unlike adults who can cryopreserve sperm at any time prior to gonadal toxic treatments, there are no effective fertility preservation options for children undergoing cancer treatment, a time when semen cryopreservation is not feasible...
December 2016: Minerva Ginecologica
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