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mTBI depression

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https://www.readbyqxmd.com/read/29388851/from-miserable-minority-to-the-fortunate-few-the-other-end-of-the-mild-traumatic-brain-injury-spectrum
#1
M E De Koning, M E Scheenen, H J Van Der Horn, J M Spikman, J Van Der Naalt
OBJECTIVES: This study, as part of the UPFRONT-study, aimed to study the patients that report zero complaints early after injury, a group that we named the 'fortunate few'. We focused on their demographic, clinical and premorbid characteristics, and examined whether they would remain asymptomatic. Moreover, we investigated the influence of anxiety and depression (HADS), and determined outcome (GOS-E) and quality of life (WHOQOL-BREF) 1 year after injury. METHODS: Patients with MTBI (Glasgow Coma Scale score 13-15), without complaints 2 weeks after injury were included...
February 1, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29388838/untangling-chronic-pain-and-post-concussion-symptoms-the-significance-of-depression
#2
Deborah L Snell, Rachelle Martin, A D Macleod, Lois J Surgenor, Richard J Siegert, E Jean C Hay-Smith, Tracy Melzer, Gary J Hooper, Tim Anderson
OBJECTIVES: Post-concussion-like symptoms (PCS) are common in patients without a history of brain injury, such as those with chronic pain (CP). This exploratory study examined neuro-cognitive and psychological functioning in patients with PCS following mild traumatic brain injury (mTBI) or CP, to assess unique and overlapping phenomenology. METHODS: In this case-control study, participants (n = 102) with chronic symptoms after mTBI (n = 45) were matched with mTBI recovered (n = 31) and CP groups (n = 26), on age, gender, ethnicity and education...
February 1, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29387781/ptsd-related-behavioral-traits-in-a-rat-model-of-blast-induced-mtbi-are-reversed-by-the-mglur2-3-receptor-antagonist-bci-838
#3
Georgina Perez-Garcia, Rita De Gasperi, Miguel A Gama Sosa, Gissel M Perez, Alena Otero-Pagan, Anna Tschiffely, Richard M McCarron, Stephen T Ahlers, Gregory A Elder, Sam Gandy
Battlefield blast exposure related to improvised explosive devices (IEDs) has become the most common cause of traumatic brain injury (TBI) in the recent conflicts in Iraq and Afghanistan. Mental health problems are common after TBI. A striking feature in the most recent veterans has been the frequency with which mild TBI (mTBI) and posttraumatic stress disorder (PTSD) have appeared together, in contrast to the classical situations in which the presence of mTBI has excluded the diagnosis of PTSD. However, treatment of PTSD-related symptoms that follow blast injury has become a significant problem...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29385020/persistent-symptoms-and-objectively-measured-balance-performance-among-oef-oif-veterans-with-remote-mild-traumatic-brain-injury
#4
Jeffrey R Hebert, Jeri E Forster, Kelly A Stearns-Yoder, Molly E Penzenik, Lisa A Brenner
OBJECTIVE: To investigate linear relationships between dizziness, fatigue, and depression and posttraumatic stress disorder (PTSD) and objectively measured balance performance in Veterans with remote mild traumatic brain injury (mTBI). SETTING: Academic laboratory; Veterans Affairs Medical Center. PARTICIPANTS: Thirty Veterans (28 men) who served in Iraq/Afghanistan and whose most recent mTBI was sustained more than 6 months prior to enrollment...
January 30, 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29382257/evaluating-anxiety-and-depression-symptoms-in-children-and-adolescents-with-prior-mild-traumatic-brain-injury-agreement-between-methods-and-respondents
#5
Vickie Plourde, Hussain Daya, Trevor A Low, Karen M Barlow, Brian L Brooks
Psychological functioning can be adversely impacted after a mild traumatic brain injury (mTBI) and may be a potential target for intervention. Despite the use of symptom ratings or structured diagnostic interview to assess long-term anxiety and depression symptoms in children and adolescents post-injury, no known studies have considered the agreement between different assessment methods and between respondents. The objectives of this study were to investigate the agreement between symptom ratings and structured diagnostic interview and between children and parents' symptom reporting...
January 30, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29357818/the-association-between-bdnf-val66met-polymorphism-and-emotional-symptoms-after-mild-traumatic-brain-injury
#6
Yu-Jia Wang, Kai-Yun Chen, Li-Na Kuo, Wen-Chang Wang, Yu-Wen Hsu, Henry Sung-Ching Wong, Chien-Min Lin, Kuo-Hsing Liao, Yan-Feng Zhang, Yung-Hsiao Chiang, Wei-Chiao Chang
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). METHODS: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI...
January 22, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29345192/cross-validation-of-the-dot-counting-test-in-a-large-sample-of-credible-and-non-credible-patients-referred-for-neuropsychological-testing
#7
Courtney McCaul, Kyle B Boone, Annette Ermshar, Maria Cottingham, Tara L Victor, Elizabeth Ziegler, Michelle A Zeller, Matthew Wright
OBJECTIVE: To cross-validate the Dot Counting Test in a large neuropsychological sample. METHOD: Dot Counting Test scores were compared in credible (n = 142) and non-credible (n = 335) neuropsychology referrals. RESULTS: Non-credible patients scored significantly higher than credible patients on all Dot Counting Test scores. While the original E-score cut-off of ≥17 achieved excellent specificity (96.5%), it was associated with mediocre sensitivity (52...
January 18, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29239280/perceived-injustice-and-its-correlates-after-mild-traumatic-brain-injury
#8
Grant L Iverson, Douglas P Terry, Justin E Karr, William Panenka, Noah D Silverberg
Perceived injustice is a belief that one has been treated unfairly, disrespectfully, and is suffering unnecessarily as a result of another person's actions. Perceived injustice predicts chronic disability after musculoskeletal injury, but to our knowledge, has not been empirically studied in people with mild traumatic brain injuries (MTBIs). We examined perceived injustice and its correlates in patients who were slow to recover from MTBI. Patients (N=102) were recruited from four concussion clinics. The sample was on average 41...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29175455/anxiolytic-and-antidepressant-like-effects-of-silymarin-compared-to-diazepam-and-fluoxetine-in-a-mouse-model-of-mild-traumatic-brain-injury
#9
Morteza Kosari-Nasab, Ghaffar Shokouhi, Amir Ghorbanihaghjo, Mehran Mesgari Abbasi, Ali-Akbar Salari
Clinical and experimental studies have shown that mild traumatic brain injury (mTBI) is associated with increased anxiety- and depression-related behaviors and inflammation in the brain. Unfortunately, there are no specific therapies for long-term behavioral consequences of mTBI. This study set out to determine whether silymarin treatment compared to diazepam (DZP) and fluoxetine (FLX) can reduce neuroinflammation, anxiety- and depression-like behaviors after mTBI induction in mice. We used open field, elevated plus maze, light-dark box, zero maze, sucrose preference, forced swim, and tail suspension tests to assess anxiety and depression-like behaviors in mTBI-induced mice...
January 1, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29052464/longitudinal-study-of-objective-and-subjective-cognitive-performance-and-psychological-distress-in-oef-oif-veterans-with-and-without-traumatic-brain-injury
#10
Kerry Donnelly, James P Donnelly, Gary C Warner, C James Kittleson, Paul R King
OBJECTIVE: To describe changes in post-deployment objective and subjective cognitive performance in combat Veterans over 18 months, relative to traumatic brain injury (TBI) status and psychological distress. METHOD: This prospective cohort study examined 500 Veterans from Upstate New York at four time points, six months apart. TBI status was determined by a structured clinical interview. Neuropsychological instruments focused on attention, memory, and executive functions...
October 20, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28980825/does-the-fear-avoidance-model-explain-persistent-symptoms-after-traumatic-brain-injury
#11
Melloney L M Wijenberg, Sven Z Stapert, Jeanine A Verbunt, Jennie L Ponsford, Caroline M Van Heugten
BACKGROUND: A minority of patients with mild traumatic brain injury (mTBI) experience a persistent symptom complex also known as post-concussion syndrome. Explanations for this syndrome are still lacking. OBJECTIVE: To investigate if the fear avoidance model, including catastrophizing thoughts and fear avoidance behaviour, poses a possible biopsychosocial explanation for lingering symptoms and delay in recovery after traumatic brain injury (TBI) with special focus on mTBI...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28979609/examining-microstructural-white-matter-in-active-duty-soldiers-with-a-history-of-mild-traumatic-brain-injury-and-traumatic-stress
#12
Michael N Dretsch, Rael T Lange, Jeffery S Katz, Adam Goodman, Thomas A Daniel, Gopikrishna Deshpande, Thomas S Denney, Grant L Iverson, Jennifer L Robinson
BACKGROUND: There is a high comorbidity of posttraumatic stress (PTS) and mild traumatic brain injury (mTBI), with largely overlapping symptomatology, in military service members. OBJECTIVE: To examine white matter integrity associated with PTS and mTBI as assessed using diffusion tensor imaging (DTI). METHOD: Seventy-four active-duty U.S. soldiers with PTS (n = 16) and PTS with co-morbid history of mTBI (PTS/mTBI; n = 28) were compared to a military control group (n = 30)...
2017: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/28904986/sex-matters-repetitive-mild-traumatic-brain-injury-in-adolescent-rats
#13
David K Wright, Terence J O'Brien, Sandy R Shultz, Richelle Mychasiuk
OBJECTIVE: Whether sex differences contribute to the heterogeneity of mild traumatic brain injury (mTBI) and repeated mTBI (RmTBI) outcomes in adolescents is unknown. Therefore, this study examined changes in, and differences between, male and female rats following single mTBI and RmTBI. METHODS: Rats were given a single mTBI, RmTBI (i.e., 3x), or sham injuries. Injuries were administered using a lateral impact model that mimics forces common in human mTBI. After the final injury, rats underwent extensive behavioral testing to examine cognition, motor function, and anxiety- and depressive-like behavior...
September 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28895451/risk-factors-for-mild-traumatic-brain-injury-and-subsequent-post-traumatic-stress-disorder-and-mental-health-disorders-among-united-states-army-soldiers
#14
Dennis E Scofield, Susan P Proctor, Joseph R Kardouni, Owen T Hill, Craig J McKinnon
The purpose of this study was to determine the association of mild traumatic brain injury (mTBI) with subsequent post-traumatic stress disorder (PTSD) and mental health disorders (MHD), and the intervening role of acute stress disorder (ASD). This matched case-control study utilized the Total Army Injury and Health Outcomes Database (TAIHOD) to analyze soldiers' (n = 1,261,297) medical encounter data between 2002 and 2011. International Classification of Diseases, Ninth Revision (ICD-9) codes were used to identify: mTBI (following Centers for Disease Control [CDC] surveillance definition for mTBI), MHD (ICD-9 codes for depression and anxiety, excluding PTSD), PTSD (ICD-9 309...
October 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28882089/the-default-mode-network-as-a-biomarker-of-persistent-complaints-after-mild-traumatic-brain-injury-a-longitudinal-functional-mri-study
#15
Harm J van der Horn, Myrthe E Scheenen, Myrthe E de Koning, Edith J Liemburg, Jacoba M Spikman, Joukje van der Naalt
The objective of this study was to examine longitudinal functional connectivity of resting-state networks in patients with and without complaints after uncomplicated mild traumatic brain injury (mTBI). Second, we aimed to determine the value of network connectivity in predicting persistent complaints, anxiety, depression and long-term outcome. Thirty mTBI patients with three or more post-traumatic complaints at 2 weeks post-injury, 19 without complaints, and 20 matched healthy controls were selected for this study...
October 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28855139/the-effect-of-an-acute-systemic-inflammatory-insult-on-the-chronic-effects-of-a-single-mild-traumatic-brain-injury
#16
Lyndsey E Collins-Praino, Alina Arulsamy, Viythia Katharesan, Frances Corrigan
A small but significant proportion of mild traumatic brain injury (mTBI) sufferers will report persistent symptoms, including depression, anxiety and cognitive deficits, in the months, or even years, following the initial event. This is known as post-concussion syndrome and its pathogenesis is not yet known. This study sought to investigate the role of a peripheral inflammatory insult in the development of ongoing behavioral symptoms following a mTBI. To investigate, male Sprague-Dawley rats were administered a single mTBI using the diffuse impact-acceleration model to generate ∼100G of force...
January 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/28828401/abnormalities-in-dynamic-brain-activity-caused-by-mild-traumatic-brain-injury-are-partially-rescued-by-the-cannabinoid-type-2-receptor-inverse-agonist-smm-189
#17
Yu Liu, Samuel S McAfee, Natalie M Guley, Nobel Del Mar, Wei Bu, Scott A Heldt, Marcia G Honig, Bob M Moore, Anton Reiner, Detlef H Heck
Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28816563/highlighting-the-differences-in-post-traumatic-symptoms-between-patients-with-complicated-and-uncomplicated-mild-traumatic-brain-injury-and-injured-controls
#18
J Julien, S Tinawi, K Anderson, L C Frenette, H Audrit, M C Ferland, M Feyz, E De Guise
OBJECTIVE: The goal of the current study is to explore the difference in acute post-concussive symptoms (PCS), headaches, sleep and mood complaints between groups of patients with complicated and uncomplicated mild traumatic brain injuries (mTBIs) and a comparable group of injured controls. Interactions among the following four factors were studied: presence of (1) PCS; (2) headaches; (3) sleep disorders; and (4) psychological status. METHODS: A total of 198 patients, followed at the outpatient mTBI clinic of the MUHC-MGH, completed questionnaires and a brief neurological assessment two weeks post-trauma...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28760573/work-productivity-loss-after-mild-traumatic-brain-injury
#19
Noah D Silverberg, William J Panenka, Grant L Iverson
OBJECTIVES: To examine the completeness of return to work (RTW) and the degree of productivity loss in individuals who do achieve a complete RTW after mild traumatic brain injury (MTBI). DESIGN: Multisite prospective cohort. SETTING: Outpatient concussion clinics. PARTICIPANTS: Patients (N=79; mean age, 41.5y; 55.7% women) who sustained an MTBI and were employed at the time of the injury. Participants were enrolled at their first clinic visit and assessed by telephone 6 to 8 months postinjury...
February 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28701496/the-spectrum-of-mild-traumatic-brain-injury-a-review
#20
REVIEW
Andrew R Mayer, Davin K Quinn, Christina L Master
OBJECTIVE: This review provides an in-depth overview of diagnostic schema and risk factors influencing recovery during the acute, subacute (operationally defined as up to 3 months postinjury), and chronic injury phases across the full spectrum of individuals (e.g., athletes to neurosurgery patients) with mild traumatic brain injury (mTBI). Particular emphasis is placed on the complex differential diagnoses for patients with prolonged postconcussive symptoms. METHODS: Select literature review and synthesis...
August 8, 2017: Neurology
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