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mTBI depression

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https://www.readbyqxmd.com/read/29175455/anxiolytic-and-antidepressant-like-effects-of-silymarin-compared-to-diazepam-and-fluoxetine-in-a-mouse-model-of-mild-traumatic-brain-injury
#1
Morteza Kosari-Nasab, Ghaffar Shokouhi, Amir Ghorbani Haghjoo, Mehran Mesgari Abbasi, Ali-Akbar Salari
Clinical and experimental studies have shown that mild traumatic brain injury (mTBI) is associated with increased anxiety- and depression-related behaviors and inflammation in the brain. Unfortunately, there are no specific therapies for long-term behavioral consequences of mTBI. This study set out to determine whether silymarin treatment compared to diazepam (DZP) and fluoxetine (FLX) can reduce neuroinflammation, anxiety- and depression-like behaviors after mTBI induction in mice. We used open field, elevated plus maze, light-dark box, zero maze, sucrose preference, forced swim, and tail suspension tests to assess anxiety and depression-like behaviors in mTBI-induced mice...
November 21, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29052464/longitudinal-study-of-objective-and-subjective-cognitive-performance-and-psychological-distress-in-oef-oif-veterans-with-and-without-traumatic-brain-injury
#2
Kerry Donnelly, James P Donnelly, Gary C Warner, C James Kittleson, Paul R King
OBJECTIVE: To describe changes in post-deployment objective and subjective cognitive performance in combat Veterans over 18 months, relative to traumatic brain injury (TBI) status and psychological distress. METHOD: This prospective cohort study examined 500 Veterans from Upstate New York at four time points, six months apart. TBI status was determined by a structured clinical interview. Neuropsychological instruments focused on attention, memory, and executive functions...
October 20, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28980825/does-the-fear-avoidance-model-explain-persistent-symptoms-after-traumatic-brain-injury
#3
Melloney L M Wijenberg, Sven Z Stapert, Jeanine A Verbunt, Jennie L Ponsford, Caroline M Van Heugten
BACKGROUND: A minority of patients with mild traumatic brain injury (mTBI) experience a persistent symptom complex also known as post-concussion syndrome. Explanations for this syndrome are still lacking. OBJECTIVE: To investigate if the fear avoidance model, including catastrophizing thoughts and fear avoidance behaviour, poses a possible biopsychosocial explanation for lingering symptoms and delay in recovery after traumatic brain injury (TBI) with special focus on mTBI...
October 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28979609/examining-microstructural-white-matter-in-active-duty-soldiers-with-a-history-of-mild-traumatic-brain-injury-and-traumatic-stress
#4
Michael N Dretsch, Rael T Lange, Jeffery S Katz, Adam Goodman, Thomas A Daniel, Gopikrishna Deshpande, Thomas S Denney, Grant L Iverson, Jennifer L Robinson
BACKGROUND: There is a high comorbidity of posttraumatic stress (PTS) and mild traumatic brain injury (mTBI), with largely overlapping symptomatology, in military service members. OBJECTIVE: To examine white matter integrity associated with PTS and mTBI as assessed using diffusion tensor imaging (DTI). METHOD: Seventy-four active-duty U.S. soldiers with PTS (n = 16) and PTS with co-morbid history of mTBI (PTS/mTBI; n = 28) were compared to a military control group (n = 30)...
2017: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/28904986/sex-matters-repetitive-mild-traumatic-brain-injury-in-adolescent-rats
#5
David K Wright, Terence J O'Brien, Sandy R Shultz, Richelle Mychasiuk
OBJECTIVE: Whether sex differences contribute to the heterogeneity of mild traumatic brain injury (mTBI) and repeated mTBI (RmTBI) outcomes in adolescents is unknown. Therefore, this study examined changes in, and differences between, male and female rats following single mTBI and RmTBI. METHODS: Rats were given a single mTBI, RmTBI (i.e., 3x), or sham injuries. Injuries were administered using a lateral impact model that mimics forces common in human mTBI. After the final injury, rats underwent extensive behavioral testing to examine cognition, motor function, and anxiety- and depressive-like behavior...
September 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28895451/risk-factors-for-mild-traumatic-brain-injury-and-subsequent-post-traumatic-stress-disorder-and-mental-health-disorders-among-united-states-army-soldiers
#6
Dennis E Scofield, Susan P Proctor, Joseph R Kardouni, Owen T Hill, Craig J McKinnon
The purpose of this study was to determine the association of mild traumatic brain injury (mTBI) with subsequent post-traumatic stress disorder (PTSD) and mental health disorders (MHD), and the intervening role of acute stress disorder (ASD). This matched case-control study utilized the Total Army Injury and Health Outcomes Database (TAIHOD) to analyze soldiers' (n = 1,261,297) medical encounter data between 2002 and 2011. International Classification of Diseases, Ninth Revision (ICD-9) codes were used to identify: mTBI (following Centers for Disease Control [CDC] surveillance definition for mTBI), MHD (ICD-9 codes for depression and anxiety, excluding PTSD), PTSD (ICD-9 309...
October 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28882089/the-default-mode-network-as-a-biomarker-of-persistent-complaints-after-mild-traumatic-brain-injury-a-longitudinal-functional-mri-study
#7
Harm J van der Horn, Myrthe E Scheenen, Myrthe E de Koning, Edith J Liemburg, Jacoba M Spikman, Joukje van der Naalt
The objective of this study was to examine longitudinal functional connectivity of resting-state networks in patients with and without complaints after uncomplicated mild traumatic brain injury (mTBI). Second, we aimed to determine the value of network connectivity in predicting persistent complaints, anxiety, depression and long-term outcome. Thirty mTBI patients with three or more post-traumatic complaints at 2 weeks post-injury, 19 without complaints, and 20 matched healthy controls were selected for this study...
October 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28855139/the-effect-of-an-acute-systemic-inflammatory-insult-on-the-chronic-effects-of-a-single-mild-traumatic-brain-injury
#8
Lyndsey E Collins-Praino, Alina Arulsamy, Viythia Katharesan, Frances Corrigan
A small but significant proportion of mild traumatic brain injury (mTBI) sufferers will report persistent symptoms, including depression, anxiety and cognitive deficits, in the months, or even years, following the initial event. This is known as post-concussion syndrome and its pathogenesis is not yet known. This study sought to investigate the role of a peripheral inflammatory insult in the development of ongoing behavioral symptoms following a mTBI. To investigate, male Sprague-Dawley rats were administered a single mTBI using the diffuse impact-acceleration model to generate ∼100G of force...
January 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/28828401/abnormalities-in-dynamic-brain-activity-caused-by-mild-traumatic-brain-injury-are-partially-rescued-by-the-cannabinoid-type-2-receptor-inverse-agonist-smm-189
#9
Yu Liu, Samuel S McAfee, Natalie M Guley, Nobel Del Mar, Wei Bu, Scott A Heldt, Marcia G Honig, Bob M Moore, Anton Reiner, Detlef H Heck
Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28816563/highlighting-the-differences-in-post-traumatic-symptoms-between-patients-with-complicated-and-uncomplicated-mild-traumatic-brain-injury-and-injured-controls
#10
J Julien, S Tinawi, K Anderson, L C Frenette, H Audrit, M C Ferland, M Feyz, E De Guise
OBJECTIVE: The goal of the current study is to explore the difference in acute post-concussive symptoms (PCS), headaches, sleep and mood complaints between groups of patients with complicated and uncomplicated mild traumatic brain injuries (mTBIs) and a comparable group of injured controls. Interactions among the following four factors were studied: presence of (1) PCS; (2) headaches; (3) sleep disorders; and (4) psychological status. METHODS: A total of 198 patients, followed at the outpatient mTBI clinic of the MUHC-MGH, completed questionnaires and a brief neurological assessment two weeks post-trauma...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28760573/work-productivity-loss-after-mild-traumatic-brain-injury
#11
Noah D Silverberg, William J Panenka, Grant L Iverson
OBJECTIVES: To examine the completeness of return to work (RTW) and the degree of productivity loss in individuals who do achieve a complete RTW after mild traumatic brain injury (MTBI). DESIGN: Multisite prospective cohort. SETTING: Outpatient concussion clinics. PARTICIPANTS: Patients (N=79; mean age, 41.5y; 55.7% women) who sustained an MTBI and were employed at the time of the injury. Participants were enrolled at their first clinic visit and assessed by telephone 6 to 8 months postinjury...
July 29, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28701496/the-spectrum-of-mild-traumatic-brain-injury-a-review
#12
REVIEW
Andrew R Mayer, Davin K Quinn, Christina L Master
OBJECTIVE: This review provides an in-depth overview of diagnostic schema and risk factors influencing recovery during the acute, subacute (operationally defined as up to 3 months postinjury), and chronic injury phases across the full spectrum of individuals (e.g., athletes to neurosurgery patients) with mild traumatic brain injury (mTBI). Particular emphasis is placed on the complex differential diagnoses for patients with prolonged postconcussive symptoms. METHODS: Select literature review and synthesis...
August 8, 2017: Neurology
https://www.readbyqxmd.com/read/28676987/white-matter-abnormalities-in-mild-traumatic-brain-injury-with-and-without-post-traumatic-stress-disorder-a-subject-specific-diffusion-tensor-imaging-study
#13
Christian Lepage, Amicie de Pierrefeu, Inga K Koerte, Michael J Coleman, Ofer Pasternak, Gerald Grant, Christine E Marx, Rajendra A Morey, Laura A Flashman, Mark S George, Thomas W McAllister, Norberto Andaluz, Lori Shutter, Raul Coimbra, Ross D Zafonte, Murray B Stein, Martha E Shenton, Sylvain Bouix
Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries...
July 5, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28653646/early-predictors-of-outcome-after-mild-traumatic-brain-injury-upfront-an-observational-cohort-study
#14
Joukje van der Naalt, Marieke E Timmerman, Myrthe E de Koning, Harm J van der Horn, Myrthe E Scheenen, Bram Jacobs, Gerard Hageman, Tansel Yilmaz, Gerwin Roks, Jacoba M Spikman
BACKGROUND: Mild traumatic brain injury (mTBI) accounts for most cases of TBI, and many patients show incomplete long-term functional recovery. We aimed to create a prognostic model for functional outcome by combining demographics, injury severity, and psychological factors to identify patients at risk for incomplete recovery at 6 months. In particular, we investigated additional indicators of emotional distress and coping style at 2 weeks above early predictors measured at the emergency department...
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28633999/characteristics-of-a-mild-traumatic-brain-injury-sample-recruited-using-amazon-s-mechanical-turk
#15
John Bernstein, Matthew Calamia
BACKGROUND: Several barriers exist in the recruitment of individuals with a history of mild traumatic brain injury (mTBI). The current study is the first to examine whether crowdsourcing, which has been used in other clinical populations, is useful in the recruitment of those with mTBI. OBJECTIVE: To examine whether Amazon's Mechanical Turk (MTurk), an online crowdsourcing platform, is a useful tool in the recruitment of individuals with a history of mTBI and to examine the injury and psychological characteristics of individuals who report a history of mTBI...
June 19, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28595276/premorbid-iq-predicts-postconcussive-symptoms-in-oef-oif-ond-veterans-with-mtbi
#16
Jada J Stewart-Willis, Daniel Heyanka, Zoe Proctor-Weber, Heather England, Maya Bruhns
Objective: Extant literature has demonstrated that symptoms of postconcussive syndrome (PCS) persist well beyond the expected 3-month post-injury recovery period in a minority of individuals with mild traumatic brain injury (mTBI). Suboptimal performance on validity measures and pre- and post-injury psychosocial stressors - rather than actual mTBI or current cognitive functioning - have been identified as predictors of chronic PCS. Whether premorbid IQ has any influence on chronic PCS has been understudied, in the context of established psychogenic etiologies...
June 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28557049/left-dorsolateral-prefrontal-cortex-rtms-in-alleviating-mtbi-related-headaches-and-depressive-symptoms
#17
Albert Leung, Valerie Metzger-Smith, Yifan He, James Cordero, Brandon Ehlert, David Song, Lisa Lin, Golshan Shahrokh, Alice Tsai, Michael Vaninetti, Thomas Rutledge, Greg Polston, Robert Sheu, Roland Lee
OBJECTIVE: Persistent mild traumatic brain injury related headache (MTBI-HA) represents a neuropathic pain state. This study tested the hypothesis that repetitive transcranial magnetic stimulation (rTMS) at the left prefrontal cortex can alleviate MTBI-HA and associated neuropsychological dysfunctions. METHODS AND MATERIALS: Veterans with MTBI-HA were randomized to receive four sessions of either real (REAL group) or sham (SHAM group) high frequency rTMS delivered at 10 Hz, 80% of resting motor threshold and 2000 pulses per session at >24 and <72 hours apart...
May 30, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28520663/contributions-to-executive-dysfunction-in-operation-enduring-freedom-operation-iraqi-freedom-veterans-with-posttraumatic-stress-disorder-and-history-of-mild-traumatic-brain-injury
#18
Sarah M Jurick, Laura D Crocker, Mark Sanderson-Cimino, Amber V Keller, Liljana S Trenova, Briana L Boyd, Elizabeth W Twamley, Carie S Rodgers, Dawn M Schiehser, Robin L Aupperle, Amy J Jak
OBJECTIVE: Posttraumatic stress disorder (PTSD), history of mild traumatic brain injury (mTBI), and executive function (EF) difficulties are prevalent in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans. We evaluated the contributions of injury variables, lower-order cognitive component processes (processing speed/attention), and psychological symptoms to EF. PARTICIPANTS: OEF/OIF Veterans (N = 65) with PTSD and history of mTBI were administered neuropsychological tests of EF and self-report assessments of PTSD and depression...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28483653/mental-health-does-not-moderate-compensatory-cognitive-training-efficacy-for-veterans-with-a-history-of-mild-traumatic-brain-injury
#19
RANDOMIZED CONTROLLED TRIAL
Kathleen F Pagulayan, Maya O'Neil, Rhonda M Williams, Aaron P Turner, Shahrokh Golshan, Mai S Roost, Benjamin Laman-Maharg, Marilyn Huckans, Daniel Storzbach, Elizabeth W Twamley
OBJECTIVE: To examine the potential moderating effects of mental health symptoms on the efficacy of compensatory cognitive training (CCT) for Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn veterans with a history of mild traumatic brain injury (mTBI). DESIGN: Secondary analysis of a randomized controlled trial of CCT. Posttraumatic stress disorder, depression, and substance dependence symptom severity were examined as potential moderators of CCT efficacy for subjective cognitive complaints, use of cognitive strategies, and objective neurocognitive performance...
September 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28449903/individuals-with-pain-need-more-sleep-in-the-early-stage-of-mild-traumatic-brain-injury
#20
Yoshitaka Suzuki, Samar Khoury, Héjar El-Khatib, Jean-Marc Chauny, Jean Paquet, Jean-François Giguère, Ronald Denis, Nadia Gosselin, Gilles J Lavigne, Caroline Arbour
OBJECTIVE: Hypersomnia is frequently reported after mild traumatic brain injury (mTBI), but its cause(s) remain elusive. This study examined sleep/wake activity after mTBI and its association with pain, a comorbidity often associated with insomnia. METHODS: Actigraphy recording was performed for 7 ± 2 consecutive days in 56 individuals at one month post-mTBI (64% male; 38 ± 12 years), 24 individuals at one year post-mTBI (58% male; 44 ± 11years), and in 20 controls (50% male; 37 ± 12 years)...
May 2017: Sleep Medicine
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