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Neonate and polycythemia

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https://www.readbyqxmd.com/read/27896259/prenatal-diagnosis-of-spontaneous-twin-anemia-polycythemia-sequence-and-postnatal-examination-of-placental-vascular-anastomoses
#1
Jin Young Bae, Jin Ju Oh, Seong Yeon Hong
Twin anemia-polycythemia sequence (TAPS) is characterized by a wide discrepancy of hemoglobin between two monochorionic fetuses without sign of twin oligo-polyhydramnios sequence. A primiparous woman with monochorionic diamniotic twin transferred for preterm labor. Ultrasonographic evaluation at 32+3 weeks of gestation revealed increased middle cerebral artery-peak systolic velocity (77.4 cm/sec, 1.69 multiples of median) in donor and decreased in recipient twin (36.4 cm/sec, 0.79 multiples of median), the twin was diagnosed with TAPS...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27889725/fluid-supplementation-versus-no-fluid-supplementation-in-late-preterm-and-term-neonates-with-asymptomatic-polycythemia-a-randomized-controlled-trial
#2
Mangalabharathi Sundaram, Sourabh Dutta, Anil Narang
OBJECTIVE: To compare supplemental intravenous fluids with no supplementation in asymptomatic polycythemic late preterm and term neonates. METHODS: 55 infants with venous haematocrit of 65-75 were randomly allocated to receive either 25 mL/kg IV normal saline over 6-8 hours or routine fluids. They were followed up for 48 hours. RESULTS: There was no significant difference between fluid supplementation and control groups regarding need for partial exchange transfusion [6/27 (22...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27734505/amniotic-fluid-discordance-in-monochorionic-diamniotic-twin-pregnancies-is-associated-with-increased-risk-for-twin-anemia-polycythemia-sequence
#3
Liran Hiersch, Mayan Eitan, Eran Ashwal, Boaz Weisz, Benny Chayen, Shlomo Lipitz, Yoav Yinon
OBJECTIVE: To estimate the risk for twin anemia-polycythemia sequence (TAPS) and adverse perinatal outcome in monochorionic diamniotic (MCDA) twin pregnancies with amniotic fluid discordance (AFD). METHODS: Retrospective cohort study of 34 MCDA pregnancies with AFD (intertwin difference of ≥3 cm in maximal vertical pocket measurement) without meeting the criteria for twin to twin transfusion syndrome (TTTS) or selective intrauterine growth restriction (sIUGR)...
October 12, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27441006/intrauterine-growth-restriction-antenatal-and-postnatal-aspects
#4
REVIEW
Deepak Sharma, Sweta Shastri, Pradeep Sharma
Intrauterine growth restriction (IUGR), a condition that occurs due to various reasons, is an important cause of fetal and neonatal morbidity and mortality. It has been defined as a rate of fetal growth that is less than normal in light of the growth potential of that specific infant. Usually, IUGR and small for gestational age (SGA) are used interchangeably in literature, even though there exist minute differences between them. SGA has been defined as having birth weight less than two standard deviations below the mean or less than the 10th percentile of a population-specific birth weight for specific gestational age...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27240984/effects-of-quercetin-on-predator-stress-related-hematological-and-behavioral-alterations-in-pregnant-rats-and-their-offspring
#5
Mohamed L Toumi, Sameha Merzoug, Abdelkrim Tahraoui
This study aims at investigating the effect of a psychogenic stress during gestation on the behaviour and haematological indices in dams as well as on the neonatal haematological status and periadolescent behaviour in their offspring. Moreover, the ability of quercetin, a natural flavonoid, to prevent the stress-induced changes was estimated. Pregnant Wistar rats were pretreated with quercetin before the exposure to a predator stress on gestational day 19. Post-stress maternal anxiety-like behaviour was assessed with a concomitant haematological analysis...
June 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27203607/solomon-technique-versus-selective-coagulation-for-twin-twin-transfusion-syndrome
#6
Femke Slaghekke, Dick Oepkes
Monochorionic twin pregnancies can be complicated by twin-to-twin transfusion syndrome (TTTS). The best treatment option for TTTS is fetoscopic laser coagulation of the vascular anastomoses between donor and recipient. After laser therapy, up to 33% residual anastomoses were seen. These residual anastomoses can cause twin anemia polycythemia sequence (TAPS) and recurrent TTTS. In order to reduce the number of residual anastomoses and their complications, a new technique, the Solomon technique, where the whole vascular equator will be coagulated, was introduced...
June 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27068715/twin-anemia-polycythemia-sequence-current-views-on-pathogenesis-diagnostic-criteria-perinatal-management-and-outcome
#7
Lisanne S A Tollenaar, Femke Slaghekke, Johanna M Middeldorp, Frans J Klumper, Monique C Haak, Dick Oepkes, Enrico Lopriore
Monochorionic twins share a single placenta and are connected with each other through vascular anastomoses. Unbalanced inter-twin blood transfusion may lead to various complications, including twin-to-twin transfusion syndrome (TTTS) and twin anemia polycythemia sequence (TAPS). TAPS was first described less than a decade ago, and the pathogenesis of TAPS results from slow blood transfusion from donor to recipient through a few minuscule vascular anastomoses. This gradually leads to anemia in the donor and polycythemia in the recipient, in the absence of twin oligo-polyhydramnios sequence (TOPS)...
June 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/26833637/re-review-of-the-correlation-between-blood-flow-velocity-and-polycythemia-in-the-fetus-neonate-and-adult-appropriate-diagnostic-levels-need-to-be-determined-for-twin-anemia-polycythemia-sequence-a-lucewicz-k-fisher-a-henry-and-a-w-welsh-ultrasound-obstet-gynecol
#8
COMMENT
https://www.readbyqxmd.com/read/26727865/neonatal-abstinence-syndrome-diagnostic-dilemmas-in-the-maternity-ward
#9
Tanja Lazić Mitrović, Željko Miković, Vesna Mandić, Lidija Hajnal Avramović, Djurdjica Ćećez, Aleksandar Stanimirović, Borisav Janković
INTRODUCTION: Neonatal abstinence syndrome (NAS) refers to a newborn neurological, gastrointestinal and/or respiratory disorder if a newborn was exposed to psychoactive substances in the intrauterine period. NAS is difficult to diagnose due to unreliability of the data on addictive substances use during pregnancy, limited possibilities of the prenatal exposure diagnosis and postnatal substance detection, which all lead to diagnostic dilemmas. OBJECTIVE: The aim of this study was to indicate the problems in patients with early NAS diagnosis in the maternity ward and the importance of clinical presentation used as a guide toward the diagnosis...
September 2015: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/26663574/can-middle-cerebral-artery-peak-systolic-velocity-predict-polycythemia-in-monochorionic-diamniotic-twins-evidence-from-a-prospective-cohort-study
#10
Michal Fishel-Bartal, Boaz Weisz, Shali Mazaki-Tovi, Eran Ashwal, Benjamin Chayen, Shlomo Lipitz, Yoav Yinon
OBJECTIVE: Antenatal diagnosis of twin anemia-polycythemia sequence (TAPS) in monochorionic diamniotic (MCDA) twin pregnancies is based on elevated peak systolic velocity in the middle cerebral artery (MCA-PSV) in the donor twin and decreased MCA-PSV in the recipient twin. However, the association between these parameters and neonatal polycythemia has not been established. The aim of this study was to determine whether MCA-PSV can predict polycythemia in MCDA pregnancies. METHODS: Prospective cohort study of MCDA pregnancies, recruited at 14-18 weeks of gestation...
December 11, 2015: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26580546/twin-anemia-polycythemia-sequence-perinatal-management-and-outcome
#11
Eran Ashwal, Yoav Yinon, Michal Fishel-Bartal, Abraham Tsur, Benjamin Chayen, Boaz Weisz, Shlomo Lipitz
OBJECTIVE: To determine the perinatal outcome of monochorionic twin pregnancies complicated by twin anemia-polycythemia sequence (TAPS). METHODS: All monochorionic twins diagnosed with TAPS between 2011 and 2014 were included. Each twin pair with TAPS (study group) was compared with 2 uncomplicated monochorionic twin pairs who were matched for gestational age at delivery (control group). Neonatal morbidity and mortality were evaluated. RESULTS: During the study period, 179 monochorionic twins were followed at our center, of whom 46 underwent laser ablation due to twin-to-twin transfusion syndrome...
2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/26517964/postnatal-survival-after-endoscopic-equatorial-laser-for-the-treatment-of-twin-to-twin-transfusion-syndrome
#12
Nicola Persico, Isabella Fabietti, Francesco D'Ambrosi, Maria Riccardi, Simona Boito, Luigi Fedele
BACKGROUND: Endoscopic laser coagulation of placental anastomoses is the first-line treatment for severe twin-to-twin transfusion syndrome. A recent randomized controlled trial reported that laser coagulation along the entire vascular equator was associated with a similar dual survival and survival of at least 1 twin compared with the group that was treated with the selective technique. In addition, there was a significantly lower incidence of postoperative recurrence of twin-to-twin transfusion syndrome and the development of twin anemia-polycythemia sequence in the equatorial group...
April 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26494027/increased-proportion-of-hematopoietic-stem-and-progenitor-cell-population-in-cord-blood-of-neonates-born-to-mothers-with-gestational-diabetes-mellitus
#13
Orsolya Hadarits, András Zóka, Gábor Barna, Zahra Al-Aissa, Klára Rosta, János Rigó, Alexandra Kautzky-Willer, Anikó Somogyi, Gábor Firneisz
We assessed the hematopoietic stem and progenitor cell (HSPC) population in the cord blood of neonates born to mothers with gestational diabetes mellitus (GDM) in a hypothesis generating pilot study, due to that, neonatal polycythemia may be the consequence of GDM pregnancy. Forty-five pregnant women with GDM (last trimester mean HbA1C = 33.9 mmol/mol) and 42 (nondiabetic) control pregnant women were enrolled after their routine 75 g oral glucose tolerance test (OGTT) between the 24th and 28th gestational week (with expected differences in their mean routine clinical characteristics: plasma glucose at OGTT: 0' = 5...
January 1, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/26405805/short-term-postnatal-renal-function-in-twin-anemia-polycythemia-sequence
#14
Lianne Verbeek, Femke Slaghekke, Romain Favre, Marine Vieujoz, Francesco Cavigioli, Gianluca Lista, Dick Oepkes, Enrico Lopriore
OBJECTIVE: To evaluate the short-term renal function in neonates with twin anemia-polycythemia sequence (TAPS). METHODS: All consecutive monochorionic twins with TAPS with double survivors admitted to three European centers were included in this retrospective study. Each twin pair was matched for gestational age at birth with a control twin pair unaffected by TAPS or twin-twin transfusion syndrome. Creatinine and urea levels in the first week after birth were recorded...
2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/26391439/neonatal-hairy-ear-pinnae-and-gestational-diabetes-just-a-coincidence
#15
Enrico Valerio, Laura Riello, Michela Chirico, Rossella Semenzato, Mario Cutrone
A newborn girl of 36 weeks gestation was noted to have several anomalies, including bilateral low ear attachment with ear pinnae hypertrichosis, left preauricular pit, micrognathia, short lingual frenulum, and short neck. Pregnancy history revealed poorly controlled maternal gestational diabetes (GD). Localized hypertrichosis of the ear pinnae may represent a potential marker of GD and thereby alert physicians to suspect other potentially GD-associated conditions such as macrosomia, asphyxia, respiratory distress, hypoglycemia, hypocalcemia, hyperbilirubinemia, polycythemia, hypertrophic cardiomyopathy, and congenital anomalies, particularly those involving the central nervous system...
November 2015: Pediatric Dermatology
https://www.readbyqxmd.com/read/26297943/neurodevelopmental-outcome-at-2-years-in-twin-twin-transfusion-syndrome-survivors-randomized-for-the-solomon-trial
#16
RANDOMIZED CONTROLLED TRIAL
Jeanine M M van Klink, Femke Slaghekke, Marina A Balestriero, Barbara Scelsa, Paola Introvini, Mariangela Rustico, Stefano Faiola, Monique Rijken, Hendrik M Koopman, Johanna M Middeldorp, Dick Oepkes, Enrico Lopriore
BACKGROUND: The preferred treatment for twin-twin transfusion syndrome is fetoscopic laser coagulation of inter-twin vascular anastomoses on the monochorionic placenta. Severe postoperative complications can occur when inter-twin vascular anastomoses remain patent including twin-anemia polycythemia sequence or recurrent twin-twin transfusion syndrome. To minimize the occurrence of residual anastomoses, a modified laser surgery technique, the Solomon technique, was developed in which the entire vascular equator is coagulated...
January 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26078649/zekai-tahir-burak-women-s-health-education-and-research-hospital-newborn-hearing-screening-results-and-assessment-of-the-patients
#17
İstemi Han Çelik, Fuat Emre Canpolat, Gamze Demirel, Zeynep Eras, Veli Gençay Sungur, Barış Sarıer, Uğur Dilmen
AIM: Social, emotional, cognitive and language development of infants is provided with early diagnosis of hearing deficit. Hearing deficit is reported with a rate of 1-6 in 1000 live births in healthy newborns, while it reaches up to 10-30 in 1000 live births in newborns with risk factors. We aimed to compile the results of the hearing screening program applied in our hospital. MATERIAL AND METHODS: The records of the hearing screening program were examined and the results were compiled by reaching the records of the patients who were found to have hearing deficit...
June 2014: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/26017143/hif-mediated-increased-ros-from-reduced-mitophagy-and-decreased-catalase-causes-neocytolysis
#18
Jihyun Song, Donghoon Yoon, Robert D Christensen, Monika Horvathova, Perumal Thiagarajan, Josef T Prchal
UNLABELLED: During prolonged hypoxia, hypoxia-inducible factors (HIFs) mediate an increase in erythropoiesis, leading to an increased red blood cell (RBC) mass and polycythemia. Upon return to normoxia, the increased RBC mass is abruptly overcorrected by the preferential destruction of hypoxia-formed young RBCs, a phenomenon termed neocytolysis. The molecular and biochemical mechanisms involved in neocytolysis are unknown. We developed a murine model of neocytolysis by exposing mice to 12 % oxygen for 10 days followed by return to normoxia...
August 2015: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/25854788/choosing-the-best-newborn-anthropometric-measure-associated-with-the-risks-and-outcomes-of-intrauterine-growth-restriction
#19
MULTICENTER STUDY
XiaoPing Lei, YongJun Zhang, Fang Fang, Ting Wu, Yan Chen, Jun Zhang
Intrauterine growth restriction (IUGR) is associated with various prenatal risks and postnatal adverse outcomes. The aim of this study is to choose the most sensitive newborn anthropometric measure, which is closely associated with IUGR-related risks and outcomes, to substitute IUGR after delivery. Data were obtained from the Collaborative Perinatal Project, a multicenter prospective cohort study in the United States from 1959 to 1976. Maternal heavy smoking and severe hypertensive disorders during pregnancy, neonatal polycythemia and hypothermia, low intelligence quotient (<70) at age 7 years were chosen as IUGR-related risks and outcomes...
December 2015: Clinical Pediatrics
https://www.readbyqxmd.com/read/25790745/evaluation-of-the-utility-of-in-utero-treatment-of-twin-anemia-polycythemia-sequence
#20
Nicolas Sananès, Marine Veujoz, Francois Severac, Maël Barthoulot, Nicolas Meyer, Anne-Sophie Weingertner, Monique Kohler, Fernando Guerra, Adrien Gaudineau, Israël Nisand, Romain Favre
OBJECTIVE: The aim of this study is to evaluate the interest in the in utero treatment of twin anemia-polycythemia sequence (TAPS). METHODS: The obstetrical and neonatal data on all cases of TAPS followed up in our institution between 2006 and 2013 were reviewed. Statistical analyses were conducted using Bayesian methods. RESULTS: Twenty cases of TAPS were included. Laser therapy or intrauterine transfusion (IUT) was performed on the donor twin in 9 cases...
2015: Fetal Diagnosis and Therapy
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