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https://www.readbyqxmd.com/read/29663332/enhanced-isobutanol-production-from-acetate-by-combinatorial-overexpression-of-acetyl-coa-synthetase-and-anaplerotic-enzymes-in-engineered-escherichia-coli
#1
Hun-Suk Song, Hyung-Min Seo, Jong-Min Jeon, Yu-Mi Moon, Ju Won Hong, Yoon Gi Hong, Shashi Kant Bhatia, Jungoh Ahn, Hongweon Lee, Wooseong Kim, Yong-Cheol Park, Kwon Young Choi, Yun-Gon Kim, Yung-Hun Yang
Acetic acid is an abundant material that can be used as a carbon source by microorganisms. Despite its abundance, its toxicity and low energy content make it hard to utilize as a sole carbon source for biochemical production. To increase acetate utilization and isobutanol production with engineered Escherichia coli, the feasibility of utilizing acetate and metabolic engineering was investigated. The expression of acs, pckA, and maeB increased isobutanol production by up to 26%, and the addition of TCA cycle intermediates indicated that the intermediates can enhance isobutanol production...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29662822/effects-of-three-area-laser-assisted-zona-thinning-in-8-cell-human-embryos-on-pregnancy-outcomes-in-vitro-fertilization
#2
Ju-Eun Jeong, Bo-Sun Joo, Chang-Woon Kim, Hwi-Gon Kim, Jong-Kil Joo, Kyu-Sup Lee
Objective: This study conducted a preliminary examination of the effects of three-area laser-assisted zona thinning (LAZT) during the cleavage stage of embryo development on the hatching process in human in vitro fertilization-embryo transfer (IVF-ET) with subjects of advanced female age or frozen-thawed (FT) embryos. Methods: Eight-cell stage embryos were treated with LAZT in three areas of the zona pellucida at 120° intervals. The control group was embryos without LAZT...
March 2018: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29658942/neuron-macrophage-co-cultures-to-activate-macrophages-secreting-molecular-factors-with-neurite-outgrowth-activity
#3
Hyeok Jun Yun, Eun-Hye Kim, Byung Gon Kim
There is strong evidence that macrophages can participate in the regeneration or repair of injured nervous system. Here, we describe a protocol in which macrophages are induced to produce conditioned medium (CM) that promotes neurite outgrowth. Adult dorsal root ganglion (DRG) neurons are acutely dissociated and plated. After the neurons are stably attached, peritoneal macrophages are co-cultured on a cell culture insert overlaid on the same well. Dibutyryl cyclic AMP (db-cAMP) is applied to the co-cultures for 24 h, after which the cell culture insert containing the macrophages is moved to another well to collect CM for 72 h...
March 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29650869/-introduction-of-pbpm-and-its-effects-for-a-home-care-support-clinic
#4
Hirofumi Imajo, Ryoko Ogawa, Toyoka Oka, Satoru Hasegawa, Eri Hirata, Masato Kishimoto, Keigo Yasukawa, Masayoshi Hirohara, Kazuki Kushida
Medical teams have been promoted in home care. It is possible for pharmacists who are part of a multidisciplinary team to maintain safety and improve the quality of medical care. Protocol-based pharmacotherapy management(PBPM)is recommended for cooperation between the pharmacist and the doctor in the management of pharmacotherapy. In order to introduce PBPM, it is necessary for the pharmacist and the doctor to cooperate and to extract the problems in community medicine. In this study, the clinic pharmacist examined the problem of unnecessary inquiries and proposed PBPM...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644657/enhanced-isobutanol-production-from-acetate-by-combinatorial-overexpression-of-acetyl-coa-synthetase-and-anaplerotic-enzymes-in-engineered-escherichia-coli
#5
Hun-Suk Song, Hyung-Min Seo, Jong-Min Jeon, Yu-Mi Moon, Ju Won Hong, Yoon Gi Hong, Shashi Kant Bhatia, Jungoh Ahn, Hongweon Lee, Wooseong Kim, Yong-Cheol Park, Kwon Young Choi, Yun-Gon Kim, Yung-Hun Yang
Acetic acid is an abundant material that can be used as a carbon source by microorganisms. Despite its abundance, its toxicity and low energy content make it hard to utilize as a sole carbon source for biochemical production. To increase acetate utilization and isobutanol production with engineered Escherichia coli, the feasibility of utilizing acetate and metabolic engineering was investigated. The expression of acs, pckA, and maeB increased isobutanol production by up to 26%, and the addition of TCA cycle intermediates indicated that the intermediates can enhance isobutanol production...
April 12, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29628982/endocrine-treatment-related-symptoms-and-patient-outcomes-in-breast-cancer-a-meta-analysis
#6
Tae-Kyung Yoo, Myoung-Jin Jang, Eunshin Lee, Hyeong-Gon Moon, Dong-Young Noh, Wonshik Han
Purpose: An association between endocrine treatment-related symptoms and breast cancer recurrence has been suggested previously; however, conflicting results have been reported. We performed a meta-analysis of published studies to clarify this relationship. Methods: We systematically searched PubMed, Embase, Scopus, and the Cochrane database for studies investigating the association between endocrine treatment-related symptoms and patient survival. Random-effects meta-analysis was conducted with recurrence rate as the primary outcome...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29624869/a-highly-efficient-near-infrared-emissive-copolymer-with-n-n-double-bond-%C3%AF-conjugated-system-based-on-a-fused-azobenzene-boron-complex
#7
Masayuki Gon, Kazuo Tanaka, Yoshiki Chujo
The fused azobenzene-boron complexes (BAzs) were prepared, and highly-efficient near-infrared (NIR) emission was observed from the nitrogen=nitrogen (N=N) double bond containing π-conjugated copolymer. From the optical measurements, it was found that BAz worked as a strong electron-acceptor originating from intrinsic electron-deficiency of the N=N double bond and the boron-nitrogen (B-N) coordination which dramatically lowered the energy level of the lowest unoccupied molecular orbital (LUMO) of the azobenzene ligand...
April 6, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29623377/the-increase-in-posterior-tibial-slope-provides-a-positive-biomechanical-effect-in-posterior-stabilized-total-knee-arthroplasty
#8
Kyoung-Tak Kang, Sae Kwang Kwon, Juhyun Son, Oh-Ryong Kwon, Jun-Sang Lee, Yong-Gon Koh
PURPOSE: This study aims to clarify the influence of the posterior tibial slope (PTS) on knee joint biomechanics after posterior-stabilized (PS) total knee arthroplasty (TKA) using a computer simulation. METHODS: A validated TKA computational model was used to evaluate and quantify the effects of an increased PTS. In order to conduct a squat simulation, models with a - 3° to 15° PTS using increments of 3° were developed. Forces on the quadriceps and collateral ligament, a tibial posterior translation, contact point on a polyethylene (PE) insert, and contact stress on the patellofemoral (PF) joint and post in a PE insert were compared...
April 5, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29620237/a-novel-missense-mutation-in-the-actg1-gene-in-a-family-with-congenital-autosomal-dominant-deafness-a-case-report
#9
Cha Gon Lee, Jahyeon Jang, Hyun-Seok Jin
The ACTG1 gene encodes the cytoskeletal protein γ-actin, which functions in non‑muscle cells and is abundant in the auditory hair cells of the cochlea. Autosomal dominant missense mutations in ACTG1 are associated with DFNA20/26, a disorder that is typically characterized by post‑lingual progressive hearing loss. To date, 17 missense mutations in ACTG1 have been reported in 20 families with DFNA20/26. The present study described a small family with autosomal dominant nonsyndromic hearing loss. A novel heterozygous missense mutation, c...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29619517/perfusion-mri-as-a-diagnostic-biomarker-for-differentiating-glioma-from-brain-metastasis-a-systematic-review-and-meta-analysis
#10
Chong Hyun Suh, Ho Sung Kim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim
OBJECTIVES: Differentiation of glioma from brain metastasis is clinically crucial because it affects the clinical outcome of patients and alters patient management. Here, we present a systematic review and meta-analysis of the currently available data on perfusion magnetic resonance imaging (MRI) for differentiating glioma from brain metastasis, assessing MRI protocols and parameters. METHODS: A computerised search of Ovid-MEDLINE and EMBASE databases was performed up to 3 October 2017, to find studies on the diagnostic performance of perfusion MRI for differentiating glioma from brain metastasis...
April 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29608327/association-between-breastfeeding-and-childhood-breathing-patterns-a-systematic-review-and-meta-analysis
#11
Eun Hae Park, Jae-Gon Kim, Yeon-Mi Yang, Jae-Gyu Jeon, Jun-Il Yoo, Jin-Kyu Kim, Dae-Woo Lee
OBJECTIVES: This systematic review aimed to evaluate the association between breastfeeding and breathing patterns in children. MATERIALS AND METHODS: We searched PubMed, EMBASE, Web of Science, CINAHL, and the Cochrane Central Register of Controlled Trials for publications from inception to October 1, 2017. The breastfeeding duration and period of exclusive breastfeeding were selected as primary outcomes. The odds ratio (OR) and 95% confidence interval (CI) were calculated...
April 2, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29607540/melatonin-improves-insulin-resistance-and-hepatic-steatosis-through-attenuation-of-alpha-2-hs-glycoprotein
#12
Jee-In Heo, Dae Wui Yoon, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim
Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent anti-oxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA) is one of the hepatokines and is known to be associated with insulin resistance and type 2 diabetes. The aim of this study was to determine whether melatonin improves hepatic insulin resistance and hepatic steatosis in a FETUA-dependent manner...
April 1, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29599034/clinical-outcomes-and-bearing-specific-complications-following-fourth-generation-alumina-ceramic-on-ceramic-total-hip-arthroplasty-a-single-surgeon-series-of-749-hips-at-a-minimum-of-5-year-follow-up
#13
Seung-Jae Lim, Hyung-Gon Ryu, Hyeon-Jun Eun, Chan-Woo Park, Kyeu-Back Kwon, Youn-Soo Park
BACKGROUND: The purpose of this study is to evaluate the minimum 5-year outcomes and bearing-specific complications in a single surgeon series of fourth-generation alumina ceramic-on-ceramic total hip arthroplasties (THAs). METHODS: We retrospectively analyzed 667 patients (749 hips) who underwent primary THAs by a single surgeon using fourth-generation alumina ceramic bearings. There were 315 men and 352 women with a mean age of 54.2 years. The surgeon used cementless prostheses with an identical design and BIOLOX Delta ceramics in all hips, using a 36-mm head in 472 hips (63%) and a 32-mm head in 227...
February 17, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29596378/range-sensor-based-efficient-obstacle-avoidance-through-selective-decision-making
#14
Youngbo Shim, Gon-Woo Kim
In this paper, we address a collision avoidance method for mobile robots. Many conventional obstacle avoidance methods have been focused solely on avoiding obstacles. However, this can cause instability when passing through a narrow passage, and can also generate zig-zag motions. We define two strategies for obstacle avoidance, known as Entry mode and Bypass mode. Entry mode is a pattern for passing through the gap between obstacles, while Bypass mode is a pattern for making a detour around obstacles safely...
March 29, 2018: Sensors
https://www.readbyqxmd.com/read/29593685/the-use-of-a-chimeric-rhodopsin-vector-for-the-detection-of-new-proteorhodopsins-based-on-color
#15
Alina Pushkarev, Gur Hevroni, Sheila Roitman, Jin-Gon Shim, Ahreum Choi, Kwang-Hwan Jung, Oded Béjà
Student microbial ecology laboratory courses are often conducted as condensed courses in which theory and wet lab work are combined in a very intensive short time period. In last decades, the study of marine microbial ecology is increasingly reliant on molecular-based methods, and as a result many of the research projects conducted in such courses require sequencing that is often not available on site and may take more time than a typical course allows. In this work, we describe a protocol combining molecular and functional methods for analyzing proteorhodopsins (PRs), with visible results in only 4-5 days that do not rely on sequencing...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29593385/biological-age-as-a-health-index-for-mortality-and-major-age-related-disease-incidence-in-koreans-national-health-insurance-service-health-screening-11-year-follow-up-study
#16
Young Gon Kang, Eunkyung Suh, Jae-Woo Lee, Dong Wook Kim, Kyung Hee Cho, Chul-Young Bae
Purpose: A comprehensive health index is needed to measure an individual's overall health and aging status and predict the risk of death and age-related disease incidence, and evaluate the effect of a health management program. The purpose of this study is to demonstrate the validity of estimated biological age (BA) in relation to all-cause mortality and age-related disease incidence based on National Sample Cohort database. Patients and methods: This study was based on National Sample Cohort database of the National Health Insurance Service - Eligibility database and the National Health Insurance Service - Medical and Health Examination database of the year 2002 through 2013...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29588910/effect-of-the-masseter-muscle-injection-of-botulinum-toxin-a-on-the-mandibular-bone-growth-of-developmental-rats
#17
Hyun Seok, Seong-Gon Kim, Min-Keun Kim, Insan Jang, Janghoon Ahn
Background: The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo. Methods: Eleven Sprague-Dawley rats were used, and BTX-A ( n  = 6) or saline ( n  = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis...
December 2018: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29577674/a-phase-4-study-of-nilotinib-in-korean-patients-with-philadelphia-chromosome-positive-chronic-myeloid-leukemia-in-chronic-phase-enestkorea
#18
Junghoon Shin, Youngil Koh, Seo Hyun Yoon, Joo-Youn Cho, Dae-Young Kim, Kyoo-Hyung Lee, Hyeong-Joon Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Jinny Park, Sang-Kyun Sohn, Joon Ho Moon, Yoo Jin Lee, Seonghae Yoon, Jeong-Ok Lee, June-Won Cheong, Kyoung Ha Kim, Sung-Hyun Kim, Hoon-Gu Kim, Hawk Kim, Seung-Hyun Nam, Young Rok Do, Sang-Gon Park, Seong Kyu Park, Sung Hwa Bae, Hun Ho Song, Dong-Yeop Shin, Doyeun Oh, Min Kyoung Kim, Chul Won Jung, Seonyang Park, Inho Kim
Although nilotinib has improved efficacy compared to imatinib, suboptimal response and intolerable adverse events (AEs) limit its effectiveness in many patients with chronic myeloid leukemia in chronic phase (CML-CP). We investigated the 2-year efficacy and safety of nilotinib and their relationships with plasma nilotinib concentrations (PNCs). In this open-label, multi-institutional phase 4 study, 110 Philadelphia chromosome-positive CML-CP patients were treated with nilotinib at a starting dose of 300 mg twice daily...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29572053/exposure-to-far-infrared-rays-attenuates-methamphetamine-induced-recognition-memory-impairment-via-modulation-of-the-muscarinic-m1-receptor-nrf2-and-pkc
#19
Huynh Nhu Mai, Naveen Sharma, Eun-Joo Shin, Bao Trong Nguyen, Phuong Tram Nguyen, Ji Hoon Jeong, Choon Gon Jang, Eun-Hee Cho, Seung Yeol Nah, Nam Hun Kim, Toshitaka Nabeshima, Hyoung-Chun Kim
We demonstrated that activation of protein kinase Cδ (PKCδ) and inactivation of the glutathione peroxidase-1 (GPx-1)-dependent systems are critical for methamphetamine (MA)-induced recognition memory impairment. We also demonstrated that exposure to far-infrared rays (FIR) causes induction of the glutathione (GSH)-dependent system, including induction of the GPx-1 gene. Here, we investigated whether exposure to FIR rays affects MA-induced recognition memory impairment and whether it modulates PKC, cholinergic receptors, and the GSH-dependent system...
March 20, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29567770/fit-%C3%AE-%C3%AE-t-cell-receptor-suppresses-leukemogenesis-of-pten-deficient-thymocytes
#20
Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier, Mélanie Bonnet, Stéphanie O Morin, Gérard Michel, Norbert Vey, Jacques A Nunès, Bernard Malissen, Romain Roncagalli, Bertrand Nadel, Dominique Payet-Bornet
Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To date, the role played by T cell receptor in the oncogenic transformation of developing T-cells remains unclear. Here we show that human primary T-cell acute lymphoblastic leukemias expressing a αβT cell receptor are frequently deficient for phosphatase and tensin homolog protein (PTEN), and fail to strongly respond to T cell receptor activation...
March 22, 2018: Haematologica
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