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Aram Kim, Min Seo Kim, Young-Jin Park, Woo Suk Choi, Hyoung Keun Park, Sung Hyun Paick, Myung-Soo Choo, Hyeong Gon Kim
OBJECTIVES: To assess and compare the long-term efficacy and safety of single-incision mini-slings (SIMS) except tension-free vaginal tape (TVT)-Secur with standard midurethral slings (SMUS) for female stress urinary incontinence through an updated systematic review and meta-analysis of randomized controlled trials (RCTs) comparing these 2 surgical methods. MATERIALS AND METHODS: A literature review of all RCTs comparing SIMS (Mini-Arc, Contasure-Needleless, Ophira, Tissue Fixation System, and Ajust) except TVT-Secur with SMUS was performed...
June 21, 2018: BJU International
Ho Cheol Kim, Chi Young Jung, Deog Gon Cho, Jae Hyun Jeon, Jeong Eun Lee, Jin Seok Ahn, Seung Joon Kim, Yeongdae Kim, Young Chul Kim, Jung Eun Kim, Boram Lee, Young Joo Won, Chang Min Choi
BACKGROUND: Lung cancer is a leading cause of morbidity and mortality worldwide, and the incidence continues to rise. Although many prognostic factors have been identified, the clinical characteristics and outcomes in Korean lung cancer patients are not well defined. METHODS: Of the 23,254 new lung cancer cases registered at the Korea Central Cancer Registry in 2013, total 489 patients from 19 hospitals were abstracted by the Korean Central Cancer Registry. The clinical data retrospectively analyzed, patients were followed up until December 2015...
June 19, 2018: Tuberculosis and Respiratory Diseases
Cha Gon Lee, Jeehun Lee, Munhyang Lee
Genetic heterogeneity of common genetic generalized epilepsy syndromes is frequently considered. The present study conducted a focused analysis of potential candidate or susceptibility genes for common genetic generalized epilepsy syndromes using multi-gene panel testing with next-generation sequencing. This study included patients with juvenile myoclonic epilepsy, juvenile absence epilepsy, and epilepsy with generalized tonic-clonic seizures alone. We identified pathogenic variants according to the American College of Medical Genetics and Genomics guidelines and identified susceptibility variants using case-control association analyses and family analyses for familial cases...
2018: PloS One
Hyoung-Gon Ko, Sanghyun Ye, Dae-Hee Han, Pojeong Park, Chae-Seok Lim, Kyungmin Lee, Min Zhuo, Bong-Kiun Kaang
Protein kinase M ζ is well known for its role in maintaining memory and pain. Previously, we revealed that the activation of protein kinase M ζ in the anterior cingulate cortex plays a role in sustaining neuropathic pain. However, the mechanism by which protein kinase M ζ is expressed in the anterior cingulate cortex by peripheral nerve injury, and whether blocking of protein kinase M ζ using its inhibitor, zeta inhibitory peptide, produces analgesic effects in neuropathic pain maintained chronically after injury, have not previously been resolved...
January 2018: Molecular Pain
Yong-Gon Koh, Juhyun Son, Ho-Joong Kim, Sae Kwang Kwon, Oh-Ryong Kwon, Hyo Jeong Kim, Kyoung-Tak Kang
Medial opening wedge high tibial osteotomy (HTO) makes the proximal tibia a highly unstable structure and causes plates and screws to be the potential sources for mechanical failure. However, asymmetrical callus and incomplete bone formations underneath the plates (TomoFix) have been recent concerns in clinical and experimental studies related to HTO due to the high stiffness. The purpose of this study was to evaluate the biomechanical effect of the TomoFix plate system with respect to changes in design using a computational simulation...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Sang Gon Lee, Chang Hyun Kim, Si Woo Sung, Eun Seok Lee, Min Su Goh, Ho Yub Yoon, Myung Joo Kang, Sangkil Lee, Young Wook Choi
Background: To facilitate selective and enhanced drug delivery to hepsin (Hpn)-expressing cancer cells, RIPL peptide (IPLVVPLRRRRRRRRC, 16-mer)-conjugated nanostructured lipid carriers (RIPL-NLCs) were developed. Methods: NLCs were prepared using a solvent emulsification-evaporation method and the RIPL peptide was conjugated to the maleimide-derivatized NLCs via the thiol-maleimide reaction. Employing a fluorescent probe (DiI), in vitro target-selective intracellular uptake behaviors were observed using fluorescence microscopy and flow cytometry...
2018: International Journal of Nanomedicine
Hyoung Gon Ryou, Jongbae Heo, Sun-Young Kim
INTRODUCTION: Studies of source apportionment (SA) for particulate matter (PM) air pollution have enhanced understanding of dominant pollution sources and quantification of their contribution. Although there have been many SA studies in South Korea over the last two decades, few studies provided an integrated understanding of PM sources nationwide. The aim of this study was to summarize findings of PM SA studies of South Korea and to explore study characteristics. METHODS: We selected studies that estimated sources of PM10 and PM2...
June 14, 2018: Environmental Pollution
Van Hong Nguyen, Nilesh M Meghani, Hardik H Amin, Thao T D Tran, Phuong H L Tran, Chulhun Park, Beom-Jin Lee
Albumin is the most abundant protein in blood, and is the most frequently identified protein in the protein corona of nanoparticles (NPs). Thus, albumin plays an important role in modulating NPs' physicochemical properties and bioavailability. In this study, the effect of bovine serum albumin (BSA) on gelatin-oleic nanoparticles' (GONs) physicochemical properties and cellular uptake were evaluated. Coumarin-6 was used as indicator to track the cellular uptake of GONs. The binding of BSA onto the GON surface increased the size, slightly reduced the negative net charge of the GON, and improved GON stability...
May 28, 2018: Colloids and Surfaces. B, Biointerfaces
Sung-Young Yoon, Gon-Ho Kim, Yushin Kim, Nack Hwan Kim, Sangheon Lee, Christina Kawai, Youngki Hong
OBJECTIVE:  A minimally invasive procedure for intervertebral disk resection using plasma beams has been developed. Conventional parameters for the plasma procedure such as voltage and tip speed mainly rely on the surgeon's personal experience, without adequate evidence from experiments. Our objective was to determine the optimal parameters for plasma disk resection. METHODS:  Rate of ablation was measured at different procedural tip speeds and voltages using porcine nucleus pulposi...
June 14, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Hwi Gon Kim, Ga Young Jung, Seung Bin Park, Yeon Jean Cho, Myoungseok Han
It is well known that prostaglandin (PG) E2 and PGF2α are secreted in copious amounts from the menstruating uterus. The aim of the present study was to determine whether PGs affect the growth of uterine leiomyomas (ULs) to the same extent as estrogen or progesterone (P4). The present study evaluated the expression of eight microRNAs (miRNAs) by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) through treatment with estradiol (E2), P4, PGE2, PGF2α and each antagonist or cyclooxygenase‑2 (COX‑2) inhibitor of cultured leiomyoma and myometrial cells (LC and MC, respectively)...
June 14, 2018: Molecular Medicine Reports
Jun-Ku Lee, Byung-Ho Yoon, Chi Hoon Oh, Jung Gon Kim, Soo-Hong Han
Background: Cases of low-energy-induced distal radius fracture (DRF) are increasing. Sarcopenia is considered to be an independent risk factor for fragility fractures. We compared body appendicular lean muscle mass (ALM) and bone mineral density (BMD) in patients with DRF and a comparable control population. This study aimed to investigate the correlation between skeletal muscle mass and DRF. Methods: We performed a retrospective review of patients diagnosed with fragility DRF...
May 2018: Journal of Bone Metabolism
Quang Anh Tuan Le, Hee Gon Kim, Yong Hwan Kim
The electro-biocatalytic conversion of CO2 into formic acid using whole-cell and isolated biocatalysts is useful as an alternative route for CO2 sequestration. In this study, Shewanella oneidensis MR-1 (S. oneidensis MR-1), a facultative aerobic bacterium that has been extensively studied for its utility as biofuel cells as well as for the detoxification of heavy metal oxides (i.e., MnO2 , uranium), has been applied for the first time as a whole-cell biocatalyst for formic acid synthesis from gaseous CO2 and electrons supplied from an electrode...
September 2018: Enzyme and Microbial Technology
Choong Hee Kim, Jun Sung Moon, Seung Min Chung, Eun Jung Kong, Chul Hyun Park, Woo Sung Yoon, Tae Gon Kim, Woong Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
BACKGROUND: This study aims to describe the trends in the severity and treatment modality of patients with diabetic foot ulcer (DFU) at a single tertiary referral center in Korea over the last 10 years and compare the outcomes before and after the introduction of a multidisciplinary diabetic foot team. METHODS: In this retrospective observational study, electronic medical records of patients from years 2002 to 2015 at single tertiary referral center were reviewed...
April 27, 2018: Diabetes & Metabolism Journal
Kyeong Jin Kim, Tae Yeon Kwon, Sungwook Yu, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Sin Gon Kim, Yousung Park, Nam Hoon Kim
BACKGROUND: To estimate and compare the trends of all-cause and cause-specific mortality rates for subjects with and without diabetes in South Korea, from 2003 to 2013. METHODS: Using a population-based cohort (2003 to 2013), we evaluated annual mortality rates in adults (≥30 years) with and without diabetes. The number of subjects in this analysis ranged from 585,795 in 2003 to 670,020 in 2013. RESULTS: Age- and sex-adjusted all-cause mortality rates decreased consistently in both groups from 2003 to 2013 (from 14...
April 26, 2018: Diabetes & Metabolism Journal
Jae Kil Park, Jae Jun Kim, Seok Whan Moon, Deog Gon Cho
BACKGROUND: Although neoadjuvant therapy followed by esophagectomy is well-established as being superior to upfront esophagectomy when locoregional lymph node (LN) metastasis is present in esophageal cancer, upfront esophagectomy without neoadjuvant therapy may be performed in patients with LN metastasis due to unreliable preoperative evaluations. However, outcomes in this setting remain unclear. The purpose of the present study was to clarify whether upfront esophagectomy without neoadjuvant therapy in patients with unsuspected lymph node metastasis in esophageal cancer is appropriate...
June 7, 2018: Journal of Cardiothoracic Surgery
So Young Kim, Jin Ki Kim, Byeong-Gon Kim, An-Soo Jang, Seung Ha Oh, Jun Ho Lee, Myung-Whan Seo, Moo Kyun Park
Little is known regarding the adverse effects of chronic particulate matter (PM) inhalation on the central nervous system (CNS). The present study aimed to examine how PM exposure impacts on oxidative stress and inflammatory processes, as well as the expression of interneurons and perineuronal nets (PNNs) in the CNS. BALB/c mice (6-week-old females, n = 32) were exposed to 1 to 5 μm size diesel-extracted particles (DEPs) (100 µg/m3 , 5 d/week, 5 h/day) and categorized into the following four groups: 1) 4-week DEP (n = 8); 2) 4-week control (n = 8), 3) 8-week DEP (n = 8); and 4) 8-week control (n = 8)...
June 4, 2018: Neurotoxicology
Tran Dinh Hieu, Tran Trung Duy, Le The Dung, Seong Gon Choi
To solve the problem of energy constraints and spectrum scarcity for cognitive radio wireless sensor networks (CR-WSNs), an underlay decode-and-forward relaying scheme is considered, where the energy constrained secondary source and relay nodes are capable of harvesting energy from a multi-antenna power beacon (PB) and using that harvested energy to forward the source information to the destination. Based on the time switching receiver architecture, three relaying protocols, namely, hybrid partial relay selection (H-PRS), conventional opportunistic relay selection (C-ORS), and best opportunistic relay selection (B-ORS) protocols are considered to enhance the end-to-end performance under the joint impact of maximal interference constraint and transceiver hardware impairments...
June 5, 2018: Sensors
Chang-Gu Lee, Pedro J J Alvarez, Hee-Gon Kim, Seongpil Jeong, Seunghak Lee, Ki Bong Lee, Sang-Hyup Lee, Jae-Woo Choi
Phosphorous is an essential limiting nutrient for which there is no substitute. Its efficient recovery from sewage treatment plants is important to mitigate both dependence on limited reserves of exploitable phosphate rock and eutrophication of surface waters. Here, we evaluate the use of calcium silicate hydrates (CSH) to recover phosphorous eluted from sewage sludge. Phosphorous elution experiments were conducted with acid and base leaching solutions. The phosphorous recovery efficiency with CSH was compared to that with other calcium compounds, and the final product was analyzed to assess its potential value as fertilizer...
February 2018: Chemosphere
Ju-Won Kim, You-Young Jo, Hae Yong Kweon, Dae-Won Kim, Seong-Gon Kim
Background: The objective of this study was to evaluate the changes in gene expression after incubation of cells with proteins released from different silk mat layers. Methods: A silk cocoon from Bombyx mori was separated into four layers of equal thickness. The layers were numbered from 1 to 4 (from the inner to the outer layer). The proteins were released by sonication of a silk mat layer in normal saline. The concentration of proteins was determined by spectrophotometry...
December 2018: Maxillofacial Plastic and Reconstructive Surgery
Bomin Kim, Ji-Su Park, Ha-Young Choi, Sang Sun Yoon, Won-Gon Kim
To address the drug-resistance of bacterial pathogens without imposing a selective survival pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein, which was isolated from Aspergillus terreus, reduced virulence factors (elastase, pyocyanin, and rhamnolipid) and biofilm formation via antagonizing quorum sensing (QS) receptors without affecting Pseudomonas aeruginosa cell growth. Additionally, the effects of terrein on the production of QS signaling molecules and expression of QS-related genes were verified...
June 5, 2018: Scientific Reports
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