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https://www.readbyqxmd.com/read/28634001/the-effect-of-preoperative-cognitive-behavior-and-exercise-therapy-for-patient-with-implanted-lvad-in-korea-case-presentation
#1
Yong Gon Seo, Won Hah Park, Eun Seok Jeon, Ji Dong Sung, Mi Ja Jang
Left ventricular assist devices (LVADs) are used in patients with progressive heart failure symptoms to provide circulatory support. Patients with LVADs are referred to inpatient cardiac rehabilitation to prevent postoperative complications and improve aerobic capacity and quality of life (QOL). Preoperative exercise therapy for cardiac patients is an emerging treatment modality, and several studies have reported that it improves postoperative outcomes such as length of hospital stay and postoperative complications...
June 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28629697/increase-in-furfural-tolerance-by-combinatorial-overexpression-of-nad-salvage-pathway-enzymes-in-engineered-isobutanol-producing-e-coli
#2
Hun-Suk Song, Jong-Min Jeon, Hyun-Joong Kim, Shashi Kant Bhatia, Ganesan Sathiyanarayanan, Junyoung Kim, Ju Won Hong, Yoon Gi Hong, Kwon Young Choi, Yun-Gon Kim, Wooseong Kim, Yung-Hun Yang
To reduce the furfural toxicity for biochemical production in E. coli, a new strategy was successfully applied by supplying NAD(P)H through the nicotine amide salvage pathway. To alleviate the toxicity, nicotinamide salvage pathway genes were overexpressed in recombinant, isobutanol-producing E. coli. Gene expression of pncB and nadE respectively showed increased tolerance to furfural among these pathways. The combined expression of pncB and nadE was the most effective in increasing the tolerance of the cells to toxic aldehydes...
June 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28628950/flexible-fused-azomethine-boron-complex-thermochromic-luminescence-and-thermosalient-behaviors-in-structural-transitions-between-crystalline-polymorphs
#3
Shunsuke Ohtani, Masayuki Gon, Kazuo Tanaka, Yoshiki Chujo
This manuscript reports the multi-functional boron complex presenting aggregation-induced emission (AIE), crystallization-induced emission enhancement (CIEE) and thermosalient behaviors accompanying thermochromic luminescence during crystal-crystal transitions by employing the fused azomethine ligand. In particular, we propose that these properties can be explained by molecular "flexibility" toward external stimuli including temperature changes and photo-excitation, and two types of crystal polymorphs having different absorption and luminescent properties were obtained...
June 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28627069/who-delivers-where-the-effect-of-obstetric-risk-on-facility-delivery-in-east-africa
#4
Sandra Virgo, Giorgia Gon, Francesca L Cavallaro, Wendy Graham, Susannah Woodd
OBJECTIVES: Skilled attendance at birth is key for the survival of pregnant women. This study investigates whether women at increased risk of maternal and newborn complications in four East African countries are more likely to deliver in a health facility than those at lower risk. METHODS: Demographic & Health Survey data for Kenya 2014, Rwanda 2014-15, Tanzania 2015-16 and Uganda 2011 were used to study women with a live birth in the three years preceding the survey...
June 19, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28625505/bioequivalence-study-of-a-new-fixed-dose-combination-tablet-containing-s-amlodipine-nicotinate-and-olmesartan-medoxomil-in-healthy-korean-male-subjects
#5
Mi Jin Oh, Hyun Hwan Hwang, Hyun Gyu Kim, Geun Hyeog Lee, Yun-Seok Cho, Sun Young Lee, Soo Yeon Kang, Kyung Hee Cho, Yun Young Lee, Yun Jeong Lee, Choon-Gon Jang, Seok-Yong Lee
PURPOSE: A fixed-dose combination (FDC) pill of amlodipine (relatively old calcium channel blocker as dihydropyridine) and olmesartan (relatively new angiotensin II receptor blocker) is used for hypertension that is not adequately controlled with a single-formulation drug. Because the FDC is a one-pill formulation, and amlodipine and olmesartan have different mechanisms of action, it is expected to improve patients' medication compliance and have an increased blood pressure-lowering efficacy...
June 15, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28624669/neutron-activatable-radionuclide-cancer-therapy-using-graphene-oxide-nanoplatelets
#6
Junghyun Kim, Michael Jay
Neutron-activation is a promising method of generating radiotherapeutics with minimal handling of radioactive materials. Graphene oxide nanoplatelets (GONs) were examined as a carrier for neutron-activatable holmium with the purpose of exploiting inherent characteristics for theranostic application. GONs were hypothesized to be an ideal candidate for this application owing to their desirable characteristics such as a rigid structure, high metal loading capacity, low density, heat resistance, and the ability to withstand harsh environments associated with the neutron-activation process...
June 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28623844/lc-ms-ms-characterization-anti-inflammatory-effects-and-antioxidant-activities-of-polyphenols-from-different-tissues-of-korean-petasites-japonicus-meowi
#7
Jin Young Choi, Kebede Taye Desta, Venu Venkatarame Gowda Saralamma, Sung Joong Lee, Soo Jung Lee, Seong Min Kim, Anjugam Paramanantham, Ho Jeong Lee, Yun-Hi Kim, Ho-Chul Shin, Jae-Han Shim, Sung Chul Shin, Gon-Sup Kim, A M Abd El-Aty
The Korean Petasites japonicus is a perennial plant used in folk medicine as a remedy for many diseases and popularly consumed as spring greens. Ten polyphenols were characterized from the leaves, stems, and roots of this plant via high-performance liquid chromatography-tandem mass spectrometry. Individual polyphenols were quantified for the first time using calibration curves of six structurally related external standards. Validation data indicated that correlation coefficients (R(2) ) were ≥ 0.9702 for all standards...
June 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28618365/a-highly-sensitive-and-widely-adaptable-plasmonic-aptasensor-using-berberine-for-small-molecule-detection
#8
Jin-Ho Park, Ju-Young Byun, Hyungjun Jang, Donggu Hong, Min-Gon Kim
Localized surface plasmon resonance (LSPR) biosensors allow label-free detection of small molecules in molecular binding events; however, they are limited by a relatively low sensitivity and narrow dynamic range. Here, we report highly sensitive small-molecule detection by LSPR peak shift exploiting the G-quadruplex (GQx) structure-binding characteristic of known GQx binders to enhance the LSPR signal of a plasmonic aptasensor. Six known GQx binders (thiazole orange, malachite green, crystal violet, zinc protoporphyrin IX, thioflavin T, and berberine) were tested for their ability to enhance the LSPR signal...
June 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28614069/pegylated-lipid-bilayer-wrapped-nano-graphene-oxides-for-synergistic-co-delivery-of-doxorubicin-and-rapamycin-to-prevent-drug-resistance-in-cancers
#9
Raj Kumar Thapa, Jeong Hoon Byeon, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Nano-graphene oxide (nGO) is a carbon allotrope studied for its potential as carrier for chemotherapeutic delivery and its photoablation effects. However, interaction of nGO with blood components and the subsequent toxicities warrant a hybrid system for effective cancer drug delivery. Combination chemotherapy aids in effective cancer treatment and prevention of drug resistance. Therefore, in this study, we attempted to prepare polyethylene glycosylated (PEGylated) lipid bilayer-wrapped nGO co-loaded with doxorubicin (DOX) and rapamycin (RAPA), GOLDR, for the prevention and treatment of resistant cancers...
June 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28613397/mechanochemical-ring-opening-polymerization-of-lactide-liquid-assisted-grinding-for-the-green-synthesis-of-poly-lactic-acid-with-high-molecular-weight
#10
Nuri Ohn, Jihoon Shin, Sung Sik Kim, Jeung Gon Kim
A mechanochemical polymerization of lactide is developed using ball milling. Mechanical energy from the collisions between the balls and the vessel efficiently promoted an organic-base-mediated metal- and solvent-free solid-state polymerization. Investigations on the parameters of the ball-milling synthesis revealed that the degree of lactide ring-opening polymerization could be modulated by the ball-milling time, vibration frequency, mass of the ball media, and liquid-assisted grinding. Especially, liquid-assisted grinding was found to be an important factor for achieving a high degree of mechanochemical polymerization...
June 14, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28612675/formulation-of-novel-dry-powder-inhalation-for-fluticasone-propionate-and-salmeterol-xinafoate-with-capsule-based-device
#11
Kyeong Soo Kim, Jeong Hyun Kim, Sung Giu Jin, Dong Wuk Kim, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Jong Soo Woo, Han-Gon Choi
The aim of this study was to develop a novel fluticasone propionate (FP) and salmeterol xinafoate (SX)-loaded dry powder inhaler (DPI) system, which was composed of powder formulation and performance. The air flow resistances were determined with various types of DPI device, showing that the modified RS01 device gave the specific resistance similar to the commercial DPI device. The particle properties of fluticasone propionate (FP), salmeterol xinafoate (SX) and inhalation grade lactose particles, such as particle size, size distribution and fine content, were assessed...
June 14, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28610205/-i-rhinobatos-i-i-austini-i-n-sp-a-new-species-of-guitarfish-rhinopristiformes-%C3%A2-rhinobatidae-from-the-southwestern-indian-ocean
#12
David A Ebert, Ofer Gon
Rhinobatos austini sp. n. is described from the southwestern Indian Ocean based on four specimens collected from the KwaZulu-Natal Province, South Africa and from Mozambique. The new species, with one exception, can be distinguished from all other members of this genus by a prominent teardrop-shaped dark blotch on the ventral surface of its snout. Its closest congener, R. holcorhynchus, also has a prominent teardrop-shaped blotch on its snout, but the new species differs from it by a lack of prominent thorns and tubercles on it dorsal disc surface and a very striking dorsal surface colour pattern of paired spots, some forming darker transverse bands across its back...
June 11, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608186/incidence-of-glaucomatous-visual-field-loss-after-two-decades-of-follow-up-the-rotterdam-study
#13
Henriët Springelkamp, Roger C Wolfs, Wishal D Ramdas, Albert Hofman, Johannes R Vingerling, Caroline C Klaver, Nomdo M Jansonius
To determine the incidence of glaucomatous visual field loss (GVFL) two decades after the start of the Rotterdam Study, and to compare known risk factors for open-angle glaucoma (OAG) between different clinical manifestations of OAG. Of 6806 participants aged 55 years and older from the population-based Rotterdam Study, 3939 underwent visual field testing at baseline and at least one follow-up round. The ophthalmic examinations included optic disc assessment and measurements of intraocular pressure (IOP), refractive error, diastolic blood pressure (DBP), and height and weight...
June 12, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28597397/protein-kinase-c%C3%AE-gene-depletion-protects-against-methamphetamine-induced-impairments-in-recognition-memory-and-erk1-2-signaling-via-upregulation-of-glutathione-peroxidase-1-gene
#14
The-Vinh Tran, Eun-Joo Shin, Lan Thuy Ty Nguyen, Youngho Lee, Dae-Joong Kim, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Kazuya Toriumi, Toshitaka Nabeshima, Kiyofumi Yamada, Hyoung-Chun Kim
Accumulating evidence has suggested that repeated treatment with methamphetamine (MA) resulted in cognitive impairments. Importantly, we show that selective upregulation of protein kinase Cδ (PKCδ) in the prefrontal cortex (PFC) of wild-type mice persisted for 28 days post withdrawal of MA. On day 28, the MA-induced increase in phospho-PKCδ expression and decrease in phospho-ERK1/2 expression were significantly attenuated by both the Src inhibitor PP2 and the dopamine D1 receptor antagonist SCH 23390. However, neither protein kinase A inhibitor H89 nor calmodulin-dependent protein kinase II inhibitor KN93 attenuated MA-induced alterations in phospho-PKCδ expression and phospho-ERK1/2 expression...
June 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28590396/botulinum-toxin-conjugated-with-silk-fibroin-and-4-hexylresorcinol
#15
You-Young Jo, Seong-Gon Kim, Min-Keun Kim
PURPOSE: The objective of this study was to evaluate whether silk fibroin (SF) incorporated into 4-hexylresorcinol (4HR) could increase botulinum toxin-A (BTX-A) activity. MATERIAL AND METHODS: In total, 30 rats were used for this study. The animals were divided into 6 groups according to the injected materials (SA: saline only; SF; 4HR; B2: 2 units of BTX-A; B2 + SF + 4HR: combination of B2, SF, and 4HR; B5: 5 units of BTX-A). Serial sonography was used for the evaluation of muscle thickness after injection...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28589520/role-of-mitochondria-in-methamphetamine-induced-dopaminergic-neurotoxicity-involvement-in-oxidative-stress-neuroinflammation-and-pro-apoptosis-a-review
#16
Eun-Joo Shin, Hai-Quyen Tran, Phuong-Tram Nguyen, Ji Hoon Jeong, Seung-Yeol Nah, Choon-Gon Jang, Toshitaka Nabeshima, Hyoung-Chun Kim
Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles with dynamic nature. Evidence indicated that exposure to MA can disturb mitochondrial energetic metabolism by inhibiting the Krebs cycle and electron transport chain. Alterations in mitochondrial dynamic processes, including mitochondrial biogenesis, mitophagy, and fusion/fission, have recently been shown to contribute to dopaminergic toxicity induced by MA...
June 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28587425/bathing-effects-of-east-saline-groundwater-concentrates-on-allergic-atopic-dermatitis-like-skin-lesions-induced-by-2-4-dinitrochlorobenzene-in-hairless-mice
#17
Choong-Gon Kim, Ji-Eun Lee, Da-Geum Jeong, Youn-Ho Lee, Sang-In Park, Dae-Geon Lee, Chang-Hyun Han, Su-Jin Kang, Chang-Hyun Song, Seong-Hun Choi, Young-Joon Lee, Sae-Kwang Ku
In the present study, it was evaluated whether east saline groundwater concentration solution (ESGWc) exerted a favorable inhibitory effect on 2,4-dinitrochlorobenzene (DNCB)-induced allergic/atopic-like dermatitis (AD). AD was induced and boosted by sensitization with DNCB via topical application on the dorsal back skins. Mice with DNCB-induced AD were bathed in 100-, 200- and 400-fold diluted ESGWc. After 6 weeks bathing, changes to body weight, clinical skin severity scores, scratching behavior, serum total immunoglobulin (Ig)E levels, submandibular lymph node and spleen weights, splenic cytokine levels, skin cytokine mRNA expressions, antioxidant defense systems and superoxide anion productions were recorded to determine the effects of bathing on the histopathology of dorsal back skin tissues...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28584116/high-mobility-group-box-1-as-an-autocrine-trophic-factor-in-white-matter-stroke
#18
Jun Young Choi, Yuexian Cui, Samma Tasneem Chowdhury, Byung Gon Kim
Maintenance of white matter integrity in health and disease is critical for a variety of neural functions. Ischemic stroke in the white matter frequently results in degeneration of oligodendrocytes (OLs) and myelin. Previously, we found that toll-like receptor 2 (TLR2) expressed in OLs provides cell-autonomous protective effects on ischemic OL death and demyelination in white matter stroke. Here, we identified high-mobility group box-1 (HMGB1) as an endogenous TLR2 ligand that promotes survival of OLs under ischemic stress...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28582767/effects-of-soil-water-saturation-on-sampling-equilibrium-and-kinetics-of-selected-polycyclic-aromatic-hydrocarbons
#19
Pil-Gon Kim, Ji-Yeon Roh, Yongseok Hong, Jung-Hwan Kwon
Passive sampling can be applied for measuring the freely dissolved concentration of hydrophobic organic chemicals (HOCs) in soil pore water. When using passive samplers under field conditions, however, there are factors that might affect passive sampling equilibrium and kinetics, such as soil water saturation. To determine the effects of soil water saturation on passive sampling, the equilibrium and kinetics of passive sampling were evaluated by observing changes in the distribution coefficient between sampler and soil (Ksampler/soil) and the uptake rate constant (ku) at various soil water saturations...
May 31, 2017: Chemosphere
https://www.readbyqxmd.com/read/28573923/combined-photothermal-and-photodynamic-therapy-by-hyaluronic-acid-decorated-polypyrrole-nanoparticles
#20
Tuan Hiep Tran, Hanh Thuy Nguyen, Thi Thu Phuong Tran, Sae Kwang Ku, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
AIM: To develop a nanoparticle-based platform using polypyrrole and IR-780 for effective combined photothermal and photodynamic therapy. MATERIALS & METHODS: IR-780 was loaded in a poly(lactic-co-glycolic acid) core, decorated with polypyrrole shells and hyaluronic acid (IPPH). Physicochemical properties and in vitro and in vivo anticancer effects of these nanoparticles were evaluated. RESULTS: The resulting IPPHs were spherical, small and negatively charged...
June 2, 2017: Nanomedicine
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