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Sung-Eun Kim, Jun Ho Lee, Tae Gon Kim, Yong-Ha Kim, Kyu Jin Chung
BACKGROUND: Fat grafting is a commonly performed procedure not only for augmenting the soft tissue but also for regeneration in esthetic and reconstructive plastic surgery.However, unpredictable fat survival rate because of high resorption rate is remained as the main problem. The purpose of this study was to investigate the effect of pretreatment of the recipient site to the fat survival using fractional carbon dioxide (CO2) laser. METHODS: The rats were divided to 2 groups...
October 19, 2017: Annals of Plastic Surgery
Frédéric Vauclair, Abdulaziz Aljurayyan, Fahad H Abduljabbar, Bardia Barimani, Patrick Goetti, Fiona Houghton, Edward J Harvey, Dominique M Rouleau
BACKGROUND: There are easily accessible tools on smartphones (APP) for measuring elbow range of motion (ROM). The purpose of this study is to evaluate the validity of a particular APP in determining elbow ROM in comparison with the commonly used goniometer (GON), surgeon estimation of range (EST) and measurement on X-ray (XR). METHODS: The study included 20 patients (40 elbows). Flexion, extension, pronation and supination were measured using three different methods: EST, GON and APP...
October 19, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Se Hwan Hwang, WeonSun Lee, Sang Hi Park, Hee Jin Lee, Sun Hwa Park, Dong Chang Lee, Mi Hyun Lim, Sang A Back, Byeong Gon Yun, Jung Ho Jeun, Jung Yeon Lim, Jun Myung Kang, Sung Won Kim
We evaluated the effect of serum-free and xeno-cultivation (SFXFM) on the characterization, proliferation, and differentiation properties of human nasal stem cells (airway tissue; hTMSCs). hTMSCs were isolated from 10 patients, after which patient samples were separated into two groups, an SFXFM group and a control group. The control group was treated with bovine serum-containing medium. FACS analysis revealed that SFXFM-cultured hTMSCs maintained a characteristic mesenchymal stem cell phenotype. hTMSC proliferation was not influenced by SFXFM...
2017: PloS One
Won Noh, Jungmin Kim, Sang-Jun Lee, Byung-Gon Ryu, Chang-Min Kang
Microalgae have been extensively studied for the production of various products. However, to date, microalgal biomass has not become economically feasible, mainly due to different issues such as contamination from various sources that occurs during downstream processes, and which leads to low quality biomass with limited application. In this study, to overcome contamination by flocculants and other microorganisms, the cationic biopolymer α-Poly-l-lysine (α-PLL) was applied. The cationic amine moiety and polymeric chain of α-PLL rendered microalgal harvesting efficient...
September 23, 2017: Bioresource Technology
Min Hee Hong, Chang Gon Kim, Yoon Woo Koh, Eun Chang Choi, Jinna Kim, Sun Och Yoon, Hye Ryun Kim, Byoung Chul Cho
BACKGROUND: The purpose of this study was to investigate the efficacy and safety of vinorelbine plus cisplatin chemotherapy in patients with recurrent and/or metastatic salivary gland cancer of the head and neck. METHODS: In this single-arm phase II study, patients with recurrent and/or metastatic salivary gland cancer were treated with i.v. vinorelbine (25 mg/m(2) ) on days 1 and 8 plus cisplatin (80 mg/m(2) ) on day 1 every 3 weeks for 4 or 6 cycles. The primary endpoint was the objective response rate...
October 16, 2017: Head & Neck
Min-Gon Lee, SeokJae Yoo, TaeHyung Kim, Q-Han Park
Two-dimensional transition metal chalcogenides (2D TMDCs) show photoluminescence (PL) as a result of direct band-gap transitions at visible wavelengths. Although 2D TMDCs have been considered for use in next-generation optoelectronics, practical applications are restricted by their low absorption and emission efficiency. To overcome these limitations using plasmonic local field enhancement, we propose the integration of gold nanoparticles with 2D TMDCs over a centimeter-scale area. Using self-assembled gold nanoshell monolayers, we produce a 10-fold increase in the PL of 2D TMDCs...
October 18, 2017: Nanoscale
Liana Lucchetti, Tommaso P Fraccia, Fabrizio Ciciulla, Francesco Simoni, Tommaso Bellini
We report the experimental evidence of nonlinear optical response in DNA lyotropic nematic liquid crystals. Pump-probe experiments indicate that the non-linearity is remarkably large. Quantitative assessment of the non-linear optical coefficient by transient optical grating demonstrates that the response is of the same order of the well-known Giant Optical Nonlinearity (GON) of thermotropic nematics. These results represent a further incentive to the current investigation of potential applications of DNA in biophotonics...
October 16, 2017: Optics Express
The-Vinh Tran, Eun-Joo Shin, Duy-Khanh Dang, Sung Kwon Ko, Ji Hoon Jeong, Seung-Yeol Nah, Choon-Gon Jang, Yu Jeung Lee, Kazuya Toriumi, Toshitaka Nabeshima, Hyoung-Chun Kim
We investigated whether ginsenoside Re (Re) modulates phencyclidine (PCP)-induced sociability deficits and recognition memory impairments to extend our recent finding. We examined the role of GPx-1 gene in the pharmacological activity of Re against mitochondrial dysfunction induced by PCP in the dorsolateral cortex of mice. Since mitochondrial oxidative stress activates NADPH oxidase (PHOX), we applied PHOX inhibitor apocynin for evaluating interactive modulation between GPx-1 and PHOX against PCP neurotoxicity...
October 13, 2017: Food and Chemical Toxicology
Sun-Young Kang, Bo-Min Kim, Kyung Taek Heo, Jae-Hyuk Jang, Won-Gon Kim, Young-Soo Hong
A new series comprising phenylacetyl‑homoserine lactones (HSL), caffeoyl-HSL and feruloyl-HSL was biologically synthesized using an artificial de novo biosynthetic pathway. We develop an Escherichia coli system containing an artificial biosynthetic pathway that yields phenylacetyl‑HSLs from simple carbon sources. These artificial biosynthetic pathways contained the LuxI-type synthase gene (rpaI) in addition to caffeoyl-CoA and feruloyl-CoA biosynthetic genes, respectively. Finally, the yields for caffeoyl-HSL and feruloyl-HSL were 97...
October 14, 2017: Journal of Microbiology and Biotechnology
Eun-Ji Jang, Woo Rim Choi, Soo-Yeon Kim, Soon-Seok Hong, Inmoo Rhee, Sang-Jin Lee, Sung Weon Choi, Han-Gon Choi, Soo-Jeong Lim
Studies have shown that insertion of oleic acid into lipid bilayers can modulate the membrane properties of liposomes so as to improve their function as drug carriers. Considering that 2-hydroxyoleic acid (2OHOA), a potential antitumor agent currently undergoing clinical trials, is a derivative of oleic acid, we explored the possibility of developing 2OHOA-inserted liposomes as a multifunctional carrier of antitumor drugs in the present study. The insertion of 2OHOA into lipid bilayers was confirmed by surface charge determination and differential scanning calorimetry...
November 2017: Drug Delivery
Chang Gon Kim, Hyo Sup Shim, Min Hee Hong, Yoon Jin Cha, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Jin Gu Lee, Chang Young Lee, Byoung Chul Cho, Hye Ryun Kim
This study was designed to prospectively examine whether peptide nucleic acid clamping-assisted fluorescence melting curve analysis (PANAMutyper™) is feasible for the detection of activating and acquired resistant epidermal growth factor receptor (EGFR) mutation in plasma. Patients with non-small cell lung cancer harboring activating EGFR mutations who were scheduled to undergo EGFR-tyrosine kinase inhibitors (EGFR-TKIs) were enrolled between September 2011 and March 2015. A total of 102 patients with EGFR-mutated lung cancer were enrolled, 53 had available plasma samples at disease progression, and 28 underwent serial plasma sampling during EGFR-TKI treatment...
September 12, 2017: Oncotarget
Dae Gon Kim, Yu Jin Kim, Sang Do Shin, Kyoung Jun Song, Eui Jung Lee, Yu Jin Lee, Ki Jeong Hong, Ju Ok Park, Young Sun Ro, Yoo Mi Park
OBJECTIVE: This study evaluated whether emergency medical service (EMS) use was associated with early arrival and admission for definitive care among intracerebral hemorrhage (ICH) patients. METHODS: Patients with ICH were enrolled from 29 hospitals between November 2007 and December 2012, excluding those patients with subarachnoid hemorrhage, traumatic ICH, and missing information. The patients were divided into four groups based on visit type to the definitive hospital emergency department (ED): direct visit by EMS (EMS-direct), direct visit without EMS (non-EMS-direct), transferred from a primary hospital by EMS (EMS-transfer), and transferred from a primary hospital without EMS (non-EMS-transfer)...
September 2017: Clinical and Experimental Emergency Medicine
Abhishek Sahu, Manse Kim, Jooyeon Ryu, Joon-Gon Son, Eunji Lee, Do Young Noh, Giyoong Tae
The application of pulsed and continuous wave (CW) lasers in nanomedicine has increased significantly over the last decade. Near infrared (NIR) lasers can be used for the precise control of drug release at the target site in a non-invasive manner. In this study, we have prepared nanographene oxide (nGO, size ~40nm) integrated liposomes (size ~900nm). The nGOs were not simply adsorbed onto the liposome surface but was embedded inside the liposomes as characterized by cryo-TEM, selected area electron diffraction (SAED), and fluorescence quenching studies...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Kyoung-Tak Kang, Yong-Gon Koh, Juhyun Son, Oh-Ryong Kwon, Jun-Sang Lee, Sae-Kwang Kwon
BACKGROUND: The reconstructed posterior tibial slope (PTS) plays a significant role in restoring knee kinematics in cruciate-retaining-total knee arthroplasty (TKA). A few studies have reported the effect of the PTS on biomechanics. METHODS: This study investigates the effect of the PTS on tibiofemoral (TF) kinematics, patellofemoral (PF) contact stress, and forces at the quadriceps, posterior cruciate ligament (PCL) and collateral ligament after cruciate-retaining-TKA using computer simulations...
September 21, 2017: Journal of Arthroplasty
Hee Jin Bae, Tack Geun Cho, Chang Hyun Kim, Ho Kook Lee, Jae Gon Moon, Jong Il Choi
Aortic injury during transforaminal lumbar interbody fusion (TLIF) is a rare but severe complication. We experienced aortic injury during TLIF at L3-4 with a 59-year-old woman diagnosed with an adjacent segment disease at L3-4. Severe bleeding occurred during disc space expansion, and the blood pressure dropped to 60/40 mmHg. The patient's vital sign stabilized after compression with gauze and Gelfoam in addition to blood transfusion. The patient was treated with endovascular repair using a percutaneous technique after intertransverse fusion at L3-4 was completed...
September 2017: Korean Journal of Spine
Shiro Nakahara, Shigeyoshi Gon, Hiroshi Takano
No abstract text is available yet for this article.
July 21, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Karam Kim, Sungkwan An, Byung Gon Choi, Dahye Joo, Young Min Choi, Kyu Joong Ahn, In-Sook An, Hwa Jun Cha
Arctiin, a lignin isolated from Arctium lappa, exhibits a variety of biological effects, including anti‑viral, anti‑inflammatory, and anti‑proliferative actions, in mammalian cells. In a previous study, arctiin was demonstrated to induce procollagen type I synthesis and exhibited protective effects against ultraviolet B (UVB) radiation in normal human dermal fibroblasts (nHDFs). However, the underlying molecular mechanism of arctiin‑mediated collagen synthesis remains unknown. In the present study, the mechanism for increased expression of collagen type 1α 1 chain (COL1A1) mRNA in arctiin‑induced nHDFs was identified...
October 2, 2017: Molecular Medicine Reports
Ariel Weissman, Gon Shoham, Zeev Shoham, Simon Fishel, Milton Leong, Yuval Yaron
Our objective was to evaluate and characterize the extent and patterns of worldwide usage of preimplantation genetic screening (PGS) among the assisted reproductive technique community. A prospective, web-based questionnaire with questions relating to practices of, and views on, PGS was directed to users and non-users of PGS. A total of 386 IVF units from 70 countries conducting 342,600 IVF cycles annually responded to the survey. A total of 77% of respondents routinely carry out PGS in their clinics for a variety of indications: advanced maternal age (27%), recurrent implantation failure (32%) and recurrent pregnancy loss (31%)...
September 21, 2017: Reproductive Biomedicine Online
Dahye Joo, Sungkwan An, Byung Gon Choi, Karam Kim, Young Min Choi, Kyu Joong Ahn, In-Sook An, Hwa Jun Cha
Ultraviolet (UV) light mediates skin aging and induces destruction of the dermis by modulating the expression levels of extracellular matrix‑associated genes, including collagen and matrix metalloproteinases. Sirtuin 6 (SIRT6), a member of the sirtuin family of proteins, regulates collagen metabolism and is an established anti‑aging protein. However, the exact underlying mechanism by which SIRT6 expression is regulated in dermal fibroblasts during the aging process is unclear. The present study demonstrated that expression of microRNA‑378b (miR‑378b) is induced in UVB‑exposed human dermal fibroblasts (HDFs), and this was inversely associated with the mRNA expression levels of α‑1‑type 1 collagen (COL1A1)...
September 28, 2017: Molecular Medicine Reports
Ki-Bum Won, Hyuck-Jun Yoon, Sang-Gon Lee, Yun-Kyeong Cho, Chang-Wook Nam, Seung-Ho Hur, Seung-Whan Lee, Pil-Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Young-Hak Kim, Cheol-Whan Lee, Seong-Wook Park, Seung-Jung Park
OBJECTIVE: To evaluate the long-term mortality according to obesity in patients with chronic total occlusion (CTO) lesions after successful percutaneous coronary intervention (PCI). BACKGROUND: Despite the potential impact of coronary revascularization and lesion severity on the obesity paradox, the long-term survival according to obesity in CTO patients after successful PCI has been unknown. METHODS AND RESULTS: Between January 2003 and September 2014, we examined 1,172 consecutive Korean patients with 1,190 CTO lesions who underwent successful drug-eluting stent (DES) implantation in two tertiary academic medical centers...
May 8, 2017: Catheterization and Cardiovascular Interventions
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