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https://www.readbyqxmd.com/read/29240230/lc-ms-ms-profiling-of-polyphenol-enriched-leaf-stem-and-root-extracts-of-korean-humulus-japonicus-siebold-zucc-and-determination-of-their-antioxidant-effects
#1
Jin Young Choi, Kebede Taye Desta, Soo Jung Lee, Yun-Hi Kim, Sung Chul Shin, Gon-Sup Kim, Sung Joong Lee, Jae-Han Shim, Ahmet Hacımüftüo, A M Abd El-Aty
Polyphenols from ethyl acetate extracts from the leaves, stems, and roots of Korean Humulus japonicus were comprehensively profiled using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). A total of 36 polyphenols were detected, of which 26 were structurally characterized based on their [M-H]- peak, MS/MS fragmentation pattern, UV-Vis absorption, and published data. Validation data provided satisfactory results for the evaluated parameters. The determination coefficients (R2 ) exceeded or equal to 0...
December 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29238036/identification-of-additional-ehmt2-variant-associated-with-the-risk-of-chronic-hepatitis-b-by-gwas-follow-up-study
#2
Joong-Gon Shin, Hyun Sub Cheong, Jason Yongha Kim, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Jae Youn Cheong, Sung Won Cho, Neung Hwa Park, Suhg Namgoong, Lyoung Hyo Kim, Yoon Jun Kim, Hyoung Doo Shin
Chronic hepatitis B (CHB) is a precursor to liver cirrhosis and hepatocellular carcinoma, caused by a Hepatitis B viral infection. Genome-wide association studies (GWASs) have been conducted to find genes associated with CHB risk. In previous GWAS, EHMT2 was identified as one of the susceptibility genes for CHB. To further characterize this association and discover possible causal variants, we conducted an additional association study. A total of 11 EHMT2 single-nucleotide polymorphisms (SNP) were selected and genotyped in 3902 subjects (1046 CHB patients and 2856 controls)...
December 14, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/29232294/the-need-for-consistent-predictors-of-success-for-surgical-ablation-of-atrial-fibrillation-a-call-to-action
#3
Niv Ad, Sari Diana Holmes, Jay Patel, Hyung Gon Je, Deborah J Shuman
OBJECTIVE: As with any medical therapy, identification of consistent and reliable outcome predictors is essential to understanding the efficacy of surgical ablation for atrial fibrillation. We originally intended to conduct a meta-analysis on atrial fibrillation surgical ablation to identify clinical factors that are most often associated with success. However, these studies are greatly heterogeneous. We conducted a systematic review to identify trends in outcome predictors and to provide recommendations for more uniform data analysis and reporting...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29226669/enhanced-oxidation-resistant-cu-ni-core-shell-nanoparticles-for-printed-flexible-electrodes
#4
Tae Gon Kim, Hye Jin Park, Kyoohee Woo, Sunho Jeong, Youngmin Choi, Su Yeon Lee
Conductive metallic nanomaterials applicable to low-cost and scalable methods have attracted great attention. Among these, Cu-based electrodes appear promising for flexible and stretchable electronic devices. However, Cu nanoparticle (NP)-based electrodes are inherently sensitive to oxygen and moisture, which hinder their practical applications. In this work, fabrication and application of highly conductive, robust, flexible, and oxidation-resistant Cu-Ni core-shell NP-based electrodes have been reported. Cu@Ni core-shell NPs with a tunable Ni shell thickness were synthesized by varying the Cu/Ni molar ratios in the precursor solution...
December 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29223637/the-role-of-striatal-g%C3%AE-q-11-protein-in-methamphetamine-induced-behavioral-sensitization-in-mice
#5
Kwang-Wook Lee, Kyungin Kim, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon Jang
Gαq/11 protein transduces signals from neurotransmitter receptors and has been implicated in several functions of the central nervous system. In this study, the role of Gαq/11 protein in methamphetamine (METH)-induced behavioral sensitization was investigated using neurochemical and behavioral approaches. Repeated treatment with METH (2mg/kg, intraperitoneally) significantly increased behavioral sensitization as well as Gαq/11 protein expression and Gα protein activity in the striata of mice, while a single treatment of METH at the same dose did not affect these parameters...
December 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29215451/mandibular-reconstruction-using-a-customized-three-dimensional-titanium-implant-applied-on-the-lingual-surface-of-the-mandible
#6
You-Young Jo, Seong-Gon Kim, Min-Keun Kim, Sung-Ho Shin, Janghoon Ahn, Hyun Seok
A patient had a right mandibular defect due to resection of an ameloblastoma. Previously, the defect had been reconstructed by an iliac bone graft, and subsequently, a titanium mesh with xenograft was used. However, it was not successfully reconstructed. For the recovery of mandible continuity and rehabilitation of jaw movement, we manufactured a customized 3-dimensional titanium implant by computer-aided design and manufacturing and electron beam melting technology. This implant was designed to have a porous body structure and lingual plate...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29214601/emerging-potential-of-stimulus-responsive-nanosized-anticancer-drug-delivery-systems-for-systemic-applications
#7
REVIEW
Hima Bindu Ruttala, Thiruganesh Ramasamy, Thiagarajan Madeshwaran, Tran Tuan Hiep, Umadevi Kandasamy, Kyung Taek Oh, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
The development of novel drug delivery systems based on well-defined polymer therapeutics has led to significant improvements in the treatment of multiple disorders. Advances in material chemistry, nanotechnology, and nanomedicine have revolutionized the practices of drug delivery. Stimulus-responsive material-based nanosized drug delivery systems have remarkable properties that allow them to circumvent biological barriers and achieve targeted intracellular drug delivery. Specifically, the development of novel nanocarrier-based therapeutics is the need of the hour in managing complex diseases...
December 6, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29214514/predictors-of-upstage-diagnosis-after-endoscopic-resection-of-gastric-low-grade-dysplasia
#8
Dae Hwan Kang, Cheol Woong Choi, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu
BACKGROUND: The optimal management of precursor lesions such as gastric low-grade dysplasia is crucial in order to improve gastric cancer-related mortality. However, there are no universally accepted management guidelines regarding which lesions should be resected or should be monitored by follow-up visits. PATIENTS AND METHODS: We retrospectively analyzed data from 1006 gastric low-grade dysplasia lesions that had been resected via endoscopic submucosal dissection...
December 6, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29212537/association-of-arms2-genotype-with-response-to-anti-vascular-endothelial-growth-factor-treatment-in-polypoidal-choroidal-vasculopathy
#9
Un Chul Park, Joo Young Shin, Hum Chung, Hyeong Gon Yu
BACKGROUND: To investigate whether genetic risk variants for age-related macular degeneration (AMD) are associated with response to intravitreal anti-vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV) patients. METHODS: This prospective cohort study included 95 treatment-naïve patients that underwent anti-VEGF treatment for PCV for 12 months. Patients were genotyped for 10 single nucleotide polymorphisms in eight AMD-relevant genes...
December 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29210570/single-step-lret-aptasensor-for-rapid-mycotoxin-detection
#10
Eun-Jung Jo, Ju-Young Byun, Hyoyoung Mun, Doyeon Bang, Jun Ho Son, Jae Young Lee, Luke P Lee, Min-Gon Kim
Contamination of foods by mycotoxins is a common yet serious problem. Owing to the increase in consumption of fresh produce, consumers have become aware of food safety issues caused by mycotoxins. Therefore, rapid and sensitive mycotoxin detection is in great demand in fields such as food safety and public health. Here, we report a single-step luminescence resonance energy transfer (LRET) aptasensor for mycotoxin detection. In order to accomplish the single-step sensor, our sensor was constructed by linking a quencher labeled aptamer through a linker to the surface of upconversion nanoparticles (UCNPs)...
December 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29209387/spicy-food-preference-and-risk-for-alcohol-dependence-in-korean
#11
Ji-Hun Park, Sung-Gon Kim, Ji-Hoon Kim, Jin-Seong Lee, Woo-Young Jung, Hyeon-Kyeong Kim
Objective: Previous studies have reported that both preference for spicy food and drinking behavior are associated with the activity of the opioid system in the central nervous system. The relationship between the preference for spicy food and the risk of alcohol dependence by comparing spicy food preference in alcohol-dependent patients vs. healthy controls was investigated. Also the association between the preference for spicy food and OPRM1 A118G was studied. Methods: A total of 150 Korean male patients with alcohol dependence and 100 normal male control subjects were included in this study...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29209379/gender-differences-in-suicidal-ideation-and-related-factors-among-north-korean-refugees-in-south-korea
#12
Jin-Won Noh, Hyunchun Park, Young Dae Kwon, In Hye Kim, Yo Han Lee, Yoon Jung Kim, Sin Gon Kim
Objective: According to previous social survey, a high number of North Korean refugees (NKRs) in South Korea had suicidal ideation. The purpose of this study is to examine the related factors for suicidal ideation among NKRs by gender in South Korea. Methods: We examined the sample of NKRs, 701 subjects (men=160, women=-541) residing in South Korea, the participants were enrolled from October 2008 to May 2014. The related factors with suicidal ideation in NKRs were analyzed via a logistic regression analysis...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29202795/validation-of-an-algorithm-that-determines-stroke-diagnostic-code-accuracy-in-a-japanese-hospital-based-cancer-registry-using-electronic-medical-records
#13
Yasufumi Gon, Daijiro Kabata, Keichi Yamamoto, Ayumi Shintani, Kenichi Todo, Hideki Mochizuki, Manabu Sakaguchi
BACKGROUND: This study aimed to validate an algorithm that determines stroke diagnostic code accuracy, in a hospital-based cancer registry, using electronic medical records (EMRs) in Japan. METHODS: The subjects were 27,932 patients enrolled in the hospital-based cancer registry of Osaka University Hospital, between January 1, 2007 and December 31, 2015. The ICD-10 (international classification of diseases, 10th revision) diagnostic codes for stroke were extracted from the EMR database...
December 4, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29199243/daphnane-and-phorbol-diterpenes-anti-neuroinflammatory-compounds-with-nurr1-activation-from-the-roots-and-stems-of-daphne-genkwa
#14
Baek-Soo Han, Nguyen Van Minh, Ha-Young Choi, Jung-Su Byun, Won-Gon Kim
The methanol extract of the roots and stems of Daphne genkwa and its constituents yuanhuacin (1) and genkwanine N were previously reported to have Nurr1 activating effects and neuroprotective effects in an animal model of Parkinson's disease (PD). In this study, four more daphnane-type diterpenes (acutilonine F (2), wikstroemia factor M1 (3), yuanhuadine (5), and yuanhuatine (6)) and two phorbol-type diterpenes (prostratin Q (4) and 12-O-n-deca-2,4,6-trienoyl-phorbol-(13)-acetate (7)) were isolated as Nurr1 activating compounds from the D...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29199003/implications-of-circulating-meteorin-like-metrnl-level-in-human-subjects-with-type-2-diabetes
#15
Hye Soo Chung, Soon Young Hwang, Ju Hee Choi, Hyun Jung Lee, Nam Hoon Kim, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
AIMS: Meteorin-like (Metrnl) was recently identified as a novel adipomyokine induced by exercise and cold exposure. Metrnl improves glucose tolerance, increases systemic energy expenditure, induces white adipose browning, and promotes anti-inflammatory gene programs in obese/diabetic mice. However, the relationship of Metrnl with diabetes and cardiometabolic risk variables in humans has not been explored. METHODS: In 800 subjects (400 patients with type 2 diabetes and 400 non-diabetes), Metrnl concentration was measured with an enzyme-linked immunosorbent assay, and the correlations of Metrnl level with anthropometric parameters, lifestyle factors, body composition values, and laboratory measurements were assessed...
November 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29197812/an-optical-fiber-based-lspr-aptasensor-for-simple-and-rapid-in-situ-detection-of-ochratoxin-a
#16
Bobin Lee, Jin-Ho Park, Ju-Young Byun, Joon Heon Kim, Min-Gon Kim
Label-free biosensing methods that rely on the use of localized surface plasmon resonance (LSPR) have attracted great attention as a result of their simplicity, high sensitivity, and relatively low cost. However, in-situ analysis of real samples using these techniques has remained challenging because colloidal nanoparticles (NPs) can be unstable at certain levels of pH and salt concentration. Even in the case of a chip-type LSPR sensor that can resolve the instability problem by employing NPs immobilized on the substrate, loading of a sample to sensor chip with exact volume control can be difficult for unskilled users...
November 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29197543/role-of-dopamine-d1-receptor-in-3-fluoromethamphetamine-induced-neurotoxicity-in-mice
#17
Phuong-Tram Nguyen, Eun-Joo Shin, Duy-Khanh Dang, Hai-Quyen Tran, Choon-Gon Jang, Ji Hoon Jeong, Yu Jeung Lee, Hyo Jong Lee, Yong Sup Lee, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim
3-Fluoromethamphetamine (3-FMA) is an illegal designer drug of methamphetamine (MA) derivative. Up to date, little is known about the neurotoxic potential of 3-FMA. In the present study, we investigated the role of dopamine receptors in neurotoxicity induced by 3-FMA in comparison with MA (35 mg/kg, i.p.) as a control drug. Here we found that 3-FMA (40, 60 or 80 mg/kg, i.p.) produced mortality in a dose-dependent manner in mice. Treatment with 3-FMA (40 mg/kg, i.p.) resulted in significant hyperthermia, oxidative stress and microgliosis (microglial differentiation into M1 phenotype) followed by pro-apoptotic changes and the induction of terminal deoxynucleotidyl transferase dUDP nick end labeling (TUNEL)-positive cells...
November 29, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29193390/lonicera-japonica-thunb-induces-caspase-dependent-apoptosis-through-death-receptors-and-suppression-of-akt-in-u937-human-leukemic-cells
#18
Cheol Park, Won Sup Lee, Min-Ho Han, Kyoung Seob Song, Su-Hyun Hong, Arulkumar Nagappan, Gi-Young Kim, Gon Sup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi
Decoctions obtained from the dried flowers of Lonicera japonica Thunb. (Indongcho) have been utilized in folk remedies against inflammatory diseases. Recently, many agents that have used for inflammatory diseases are showing anticancer effects. Here, we have isolated polyphenols extracted from lyophilized Lonicera japonica Thunb (PELJ) and investigated the anticancer effects of PELJ on U937 cells. Here, we demonstrated that PELJ induced apoptosis by upregulation of DR4 and Fas, and further it is augmented by suppression of XIAP...
November 29, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29190982/diagnostic-performance-enhancement-of-pancreatic-cancer-using-proteomic-multimarker-panel
#19
Jiyoung Park, Yonghwan Choi, Junghyun Namkung, Sung Gon Yi, Hyunsoo Kim, Jiyoung Yu, Yongkang Kim, Min-Seok Kwon, Wooil Kwon, Do-Youn Oh, Sun-Whe Kim, Seung-Yong Jeong, Wonshik Han, Kyu Eun Lee, Jin Seok Heo, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Chang Moo Kang, Woo Jin Lee, Seungyeoun Lee, Sangjo Han, Taesung Park, Jin-Young Jang, Youngsoo Kim
Due to its high mortality rate and asymptomatic nature, early detection rates of pancreatic ductal adenocarcinoma (PDAC) remain poor. We measured 1000 biomarker candidates in 134 clinical plasma samples by multiple reaction monitoring-mass spectrometry (MRM-MS). Differentially abundant proteins were assembled into a multimarker panel from a training set (n=684) and validated in independent set (n=318) from five centers. The level of panel proteins was also confirmed by immunoassays. The panel including leucine-rich alpha-2 glycoprotein (LRG1), transthyretin (TTR), and CA19-9 had a sensitivity of 82...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29183172/endoscopic-submucosal-dissection-of-gastric-neoplasms-using-a-snare-tip
#20
Su Jin Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Hyeong Seok Nam, Dae Gon Ryu
BACKGROUND: Endoscopic submucosal dissection (ESD) enables the complete removal of gastric lesions regardless of tumor size. ESD is typically performed using one of several available electrocautery knives and endoscopic mucosal resection (EMR) is performed using a diathermic snare. We aimed to investigate the clinical outcomes and complications in patients in whom a snare tip was used for ESD. MATERIALS AND METHODS: We retrospectively evaluated the medical records of 30 patients who underwent removal of a gastric lesion using a snare tip by ESD or hybrid ESD (ESD with snaring)...
November 28, 2017: Scandinavian Journal of Gastroenterology
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