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https://www.readbyqxmd.com/read/28210546/time-interval-of-neoadjuvant-chemotherapy-to-surgery-in-breast-cancer-how-long-is-acceptable
#1
EDITORIAL
Tae-Kyung Yoo, Hyeong-Gon Moon, Wonshik Han, Dong-Young Noh
No abstract text is available yet for this article.
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28208830/cefdinir-solid-dispersion-composed-of-hydrophilic-polymers-with-enhanced-solubility-dissolution-and-bioavailability-in-rats
#2
Hyun-Jong Cho, Jun-Pil Jee, Ji-Ye Kang, Dong-Yeop Shin, Han-Gon Choi, Han-Joo Maeng, Kwan Hyung Cho
The aim of this work was to develop cefdinir solid dispersions (CSDs) prepared using hydrophilic polymers with enhanced dissolution/solubility and in vivo oral bioavailability. CSDs were prepared with hydrophilic polymers such as hydroxypropyl-methylcellulose (HPMC; CSD1), carboxymethylcellulose-Na (CMC-Na; CSD2), polyvinyl pyrrolidone K30 (PVP K30; CSD3) at the weight ratio of 1:1 (drug:polymer) using a spray-drying method. The prepared CSDs were characterized by aqueous solubility, differential scanning calorimetry (DSC), powder X-ray diffraction (p-XRD), scanning electron microscopy (SEM), aqueous viscosity, and dissolution test in various media...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28205580/accelerated-biodegradation-of-silk-sutures-through-matrix-metalloproteinase-activation-by-incorporating-4-hexylresorcinol
#3
You-Young Jo, HaeYong Kweon, Dae-Won Kim, Min-Keun Kim, Seong-Gon Kim, Jwa-Young Kim, Weon-Sik Chae, Sam-Pyo Hong, Young-Hwan Park, Si Young Lee, Je-Yong Choi
Silk suture material is primarily composed of silk fibroin and regarded as a non-resorbable material. It is slowly degraded by proteolysis when it is implanted into the body. 4-Hexylresorcinol (4HR) is a well-known antiseptic. In this study, the biodegradability of 4HR-incorporated silk sutures were compared to that of untreated silk sutures and polyglactin 910 sutures, a commercially available resorbable suture. 4HR-incorporated silk sutures exhibited anti-microbial properties. Matrix metalloproteinase (MMP) can digest a wide spectrum of proteins...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203066/models-for-estimating-the-metabolic-syndrome-biological-age-as-the-new-index-for-evaluation-and-management-of-metabolic-syndrome
#4
Young Gon Kang, Eunkyung Suh, Hyejin Chun, Sun-Hyun Kim, Deog Ki Kim, Chul-Young Bae
PURPOSE: This study aims to propose a metabolic syndrome (MS) biological age model, through which overall evaluation and management of the health status and aging state in MS can be done easily. Through this model, we hope to provide a novel evaluation and management health index that can be utilized in various health care fields. PATIENT AND METHODS: MS parameters from American Heart Association/National Heart, Lung, and Blood Institute guidelines in 2005 were used as biomarkers for the estimation of MS biological age...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28194643/ultra-efficient-amplification-of-abnormal-prion-protein-by-modified-protein-misfolding-cyclic-amplification-with-electric-current
#5
Jeong-Ho Park, Yeong-Gon Choi, Seok-Joo Park, Hong-Seok Choi, Eun-Kyoung Choi, Yong-Sun Kim
Prion diseases are clinically diagnosed and confirmed upon post-mortem histopathological examination of brain tissue. The only reliable molecular marker for prion diseases is abnormal prion protein (PrPSc), a pathologically conformed prion protein that primarily accumulates in the central nervous system and to a lesser extent in lymphoreticular tissues. However, the use of PrPSc as a marker for preclinical diagnoses is limited because the concentration of PrPSc in easily accessible body fluids is extremely low...
February 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28194346/safe-and-simplified-salvage-technique-for-exposed-implantable-cardiac-electronic-devices-under-local-anesthesia
#6
Chang Young Jung, Tae Gon Kim, Sung-Eun Kim, Kyu-Jin Chung, Jun Ho Lee, Yong-Ha Kim
BACKGROUND: Skin erosion is a dire complication of implantable cardiac pacemakers and defibrillators. Classical treatments involve removal of the entire generator and lead systems, however, these may result in fatal complications. In this study, we present our experience with a simplified salvage technique for exposed implantable cardiac electronic devices (ICEDs) without removing the implanted device, in an attempt to reduce the risks and complication rates associated with this condition...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28193572/systematic-review-of-early-and-long-term-outcome-of-liver-resection-for-metastatic-breast-cancer-is-there-a-survival-benefit
#7
REVIEW
Tae Gon Yoo, Isaac Cranshaw, Reuben Broom, Sanjay Pandanaboyana, Adam Bartlett
BACKGROUND: Isolated liver metastases occur rarely in patients with metastatic breast cancer. The success of liver resection (LR) for other metastatic disease has led centres to explore the option of LR for patients with isolated breast cancer liver metastases (BCLM). A number of small series have been published in the literature, however the evidence is conflicting. This study aimed to systematically review the literature to determine the perioperative outcome and survival of patients undergoing LR for BCLM...
February 10, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28191699/ndrg1-is-important-to-maintain-the-integrity-of-airway-epithelial-barrier-through-claudin-9-expression
#8
Yasuhiro Gon, Shuichiro Maruoka, Hiroyuki Kishi, Yutaka Kozu, Kuroda Kazumichi, Yasuyuki Nomura, Ikuko Takeshita, Takeshi Oshima, Shu Hashimoto
Impairment of epithelial barrier integrity caused by environmental triggers is associated with the pathogenesis of airway inflammation. Using human airway epithelial cells, we attempted to identify molecule(s) that promote airway epithelial barrier integrity. Microarray analyses were conducted using the Affimetrix human whole genome gene chip, and we identified the N-myc downstream-regulated gene 1 (NDRG1) gene, which was induced during the development of the epithelial cell barrier. Immunohistochemical analysis revealed strong NDRG1 expression in ciliated epithelial cells in nasal tissues sampled from patients with chronic rhinosinusitis (CRS), and the low expression of NDRG1 was observed in goblet cells or damaged epithelial cells...
February 13, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28185146/mr-imaging-features-associated-with-distant-metastasis-free-survival-of-patients-with-invasive-breast-cancer-a-case-control-study
#9
Sung Eun Song, Sung Ui Shin, Hyeong-Gon Moon, Han Suk Ryu, Kwangsoo Kim, Woo Kyung Moon
PURPOSE: Preoperative breast magnetic resonance (MR) imaging features of primary breast cancers may have the potential to act as prognostic biomarkers by providing morphologic and kinetic features representing inter- or intra-tumor heterogeneity. Recent radiogenomic studies reveal that several radiologist-annotated image features are associated with genes or signal pathways involved in tumor progression, treatment resistance, and distant metastasis (DM). We investigate whether preoperative breast MR imaging features are associated with worse DM-free survival in patients with invasive breast cancer...
February 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28181835/irinotecan-encapsulated-double-reverse-thermosensitive-nanocarrier-system-for-rectal-administration
#10
Fakhar Ud Din, Ju Yeon Choi, Dong Wuk Kim, Omer Mustapha, Dong Shik Kim, Raj Kumar Thapa, Sae Kwang Ku, Yu Seok Youn, Kyung Taek Oh, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) for rectal administration was developed as an alternative. The DRTN was fabricated by dispersing the thermosensitive irinotecan-encapsulated solid lipid nanoparticles (SLN) in the thermosensitive poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its rectal administration to rats and tumor-bearing mice...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28173643/the-abuse-potential-of-%C3%AE-piperidinopropiophenone-pipp-and-%C3%AE-piperidinopentiothiophenone-pivt-two-new-synthetic-cathinones-with-piperidine-ring-substituent
#11
Chrislean Jun Botanas, Seong Shoon Yoon, June Bryan de la Peña, Irene Joy Dela Peña, Mikyung Kim, Taeseon Woo, Joung-Wook Seo, Choon-Gon Jang, Kyung-Tae Park, Young Hun Lee, Yong Sup Lee, Hee Jin Kim, Jae Hoon Cheong
A diversity of synthetic cathinones has flooded the recreational drug marketplace worldwide. This variety is often a response to legal control actions for one specific compound (e.g. methcathinone) which has resulted in the emergence of closely related replacement. Based on recent trends, the nitrogen atom is one of the sites in the cathinone molecule being explored by designer type modifications. In this study, we designed and synthesized two new synthetic cathinones, (1) α-piperidinopropiophenone (PIPP) and (2) α-piperidinopentiothiophenone (PIVT), which have piperidine ring substituent on their nitrogen atom...
February 6, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28161935/can-we-skip-intraoperative-evaluation-of-sentinel-lymph-nodes-nomogram-predicting-involvement-of-three-or-more-axillary-lymph-nodes-before-breast-cancer-surgery
#12
Soo Kyung Ahn, Min Kyoon Kim, Jongjin Kim, Eunshin Lee, Tae-Kyung Yoo, Han-Byoel Lee, Young Joon Kang, Jisun Kim, Hyeong-Gon Moon, Jung Min Chang, Nariya Cho, Woo Kyung Moon, In Ae Park, Dong-Young Noh, Wonshik Han
Purpose: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial reported that complete dissection of axillary lymph nodes (ALNs) may not be warranted in women with clinical T1-T2 tumors and one or two involved ALNs who were undergoing lumpectomy plus radiation followed by systemic therapy. The present study was conducted to identify preoperative imaging predictors of ≥3 ALNs. Materials and Methods: The training set consisted of 1917 patients with clinical T1-T2 and node negative invasive breast cancer...
January 25, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28158580/gclc-deficiency-in-mouse-cns-causes-mitochondrial-damage-and-neurodegeneration
#13
Weiyi Feng, Mariana Rosca, Yuxuan Fan, Yufen Hu, Pingfu Feng, Hyoung-Gon Lee, Vincent M Monnier, Xingjun Fan
No abstract text is available yet for this article.
January 31, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28157684/cdk5-foxo3-axis-initially-neuroprotective-eventually-neurodegenerative-in-alzheimer-s-disease-models
#14
Chun Shi, Keith Viccaro, Hyoung-Gon Lee, Kavita Shah
Deregulated Cdk5 causes neurotoxic amyloid beta peptide (Aβ) processing and cell death, two hallmarks of Alzheimer's disease, through the Foxo3 transcriptional factor in hippocampal cells, primary neurons and an Alzheimer's disease mouse model. Using an innovative chemical genetic screen, we identified Foxo3 as a direct substrate of Cdk5 in brain lysates. Cdk5 directly phosphorylates Foxo3, which increased its levels and nuclear translocation. Nuclear Foxo3 initially rescued cells from ensuing oxidative stress by upregulating MnSOD (also known as SOD2)...
May 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/28150412/new-application-of-three-dimensional-printing-biomaterial-in-nasal-reconstruction
#15
Sun Hwa Park, Byeong Gon Yun, Joo Yun Won, Won Soo Yun, Jin Hyung Shim, Mi Hyun Lim, Do Hyun Kim, Sang A Baek, Yahya Dhafer Alahmari, Jun Ho Jeun, Se Hwan Hwang, Sung Won Kim
OBJECTIVES: Polycaprolactone (PCL) is an U.S. Food and Drug Administration-approved synthetic biodegradable polymer and is easily fabricated into three-dimensional (3D) structures. In this study, the 3D-printed PCL implant for nasal augmentation was further evaluated for its suitability for nasal surgeries such as septoplasty and rhinoplasty. METHODS: Ten New Zealand White rabbits were included and divided into study and sham groups (7 and 3, respectively). A lateral incision was made on the nasal dorsum and a pocket formed in the subperichondrial plane between the upper lateral cartilage and nasal septum...
February 1, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28134459/rabies-virus-inspired-silica-coated-gold-nanorods-as-a-photothermal-therapeutic-platform-for-treating-brain-tumors
#16
Changkyu Lee, Ha Shin Hwang, Sungin Lee, Bomi Kim, Jong Oh Kim, Kyung Taek Oh, Eun Seong Lee, Han-Gon Choi, Yu Seok Youn
Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These nanorods not only resemble the appearance of the actual rabies virus but also travel into the brain through the neuronal pathway bypassing the blood-brain barrier, and moreover respond to near-infrared laser (808 nm) irradiation, emit heat, and effectively suppress brain tumors.
January 30, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28131770/dopamine-d3-receptor-modulated-neuroprotective-effects-of-lisuride
#17
Munki Kim, Sijoon Lee, Jeahyeon Cho, Gonsup Kim, Chungkil Won
Dopamine (DA) contributes to the regulation of voluntary movement, and a deficiency in DAergic neurons leads to movement disorders. The objective of this study was to examine the neuroprotective effect of DA D2-like receptor agonist, lisuride, and the role of DA receptors in this protection. Treatment with lisuride alleviated loss of tyrosine hydroxylase (TH) both direct and intraperitoneal injection in 6-hydroxydopamine (6-OHDA) mouse model. Similar results were obtained in primary neuronal cultures treated with lisuride...
January 25, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28123419/correction-regeneration-associated-macrophages-a-novel-approach-to-boost-intrinsic-regenerative-capacity-for-axon-regeneration
#18
Min Jung Kwon, Hyuk Jun Yoon, Byung Gon Kim
[This corrects the article on p. 1368 in vol. 11, PMID: 27857723.].
November 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28122339/molecularly-targeted-co-delivery-of-a-histone-deacetylase-inhibitor-and-paclitaxel-by-lipid-protein-hybrid-nanoparticles-for-synergistic-combinational-chemotherapy
#19
Hima Bindu Ruttala, Thiruganesh Ramasamy, Bijay Kumar Poudal, Yongjoo Choi, Ju Yeon Choi, Jeonghwan Kim, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In this study, a transferrin-anchored albumin nanoplatform with PEGylated lipid bilayers (Tf-L-APVN) was developed for the targeted co-delivery of paclitaxel and vorinostat in solid tumors. Tf-L-APVN exhibited a sequential and controlled release profile of paclitaxel and vorinostat, with an accelerated release pattern at acidic pH. At cellular levels, Tf-L-APVN significantly enhanced the synergistic effects of paclitaxel and vorinostat on the proliferation of MCF-7, MDA-MB-231, and HepG2 cancer cells. Vorinostat could significantly enhance the cytotoxic potential of paclitaxel, induce marked cell apoptosis, alter cell cycle patterns, and inhibit the migratory capacity of cancer cells...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28121051/optically-active-phenylethene-dimers-based-on-planar-chiral-tetrasubstituted-2-2-paracyclophane
#20
Masayuki Gon, Yasuhiro Morisaki, Yoshiki Chujo
Optically active phenylethene dimers based on a planar chiral 4,7,12,15-tetrasubstituted [2.2]paracyclophane were synthesized. We succeeded in controlling the molecular motion by binding luminophores in close proximity with the [2.2]paracyclophane scaffold. For example, aggregation-induced emission (AIE)-active luminophores were converted to show intense photoluminescence (PL) even in a diluted solution at room temperature and the resulting compound worked as a single-molecule thermo-responsible material around room temperature...
January 25, 2017: Chemistry: a European Journal
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