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Ju Yeon Choi, Biki Gupta, Thiruganesh Ramasamy, Jee-Heon Jeong, Sung Giu Jin, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
The major goal of cancer chemotherapy is to maximize the therapeutic efficacy of anticancer drugs, while minimizing their associated side effects. Celastrol (CST), which is extracted from the traditional Chinese medicinal plant Tripterygium wilfordii, has been reported to exhibit significant anticancer effects in various in vitro and in vivo cancer models. Nanoparticulate drug delivery systems could be employed to preserve and enhance the pharmacological effects of CST in cancer cells. Among these, mesoporous silica nanoparticles (MSNs) are one of the most promising drug delivery systems...
February 11, 2018: Colloids and Surfaces. B, Biointerfaces
Young-Gon Kim, Kuk-Hyun Song, Dong-Hoon Lee, Sung-Min Joo
The demand of crack tip opening displacement (CTOD) test which evaluates fracture toughness of a cracked material is very important to ensure the stability of structure under severe service environment. The validity of the CTOD test result is judged using several criterions of the specification standards. One of them is the artificially generated fatigue pre-crack length inside the specimen. For acceptable CTOD test results, fatigue pre-crack must have a reasonable sharp crack front. The propagation of fatigue crack started from the tip of the machined notch, which might have propagated irregularly due to residual stress field...
March 1, 2018: Journal of Nanoscience and Nanotechnology
In-Seok Seo, Hwan-Gon Lee, Bonkon Koo, Chin Su Koh, Hae-Yong Park, Changkyun Im, Hyung-Cheul Shin
Although several studies have been performed to detect cancer using canine olfaction, none have investigated whether canine olfaction trained to the specific odor of one cancer is able to detect odor related to other unfamiliar cancers. To resolve this issue, we employed breast and colorectal cancer in vitro, and investigated whether trained dogs to odor related to metabolic waste from breast cancer are able to detect it from colorectal cancer, and vice versa. The culture liquid samples used in the cultivation of cancerous cells (4T1 and CT26) were employed as an experimental group...
2018: PloS One
Kyoung-Tak Kang, Yong-Gon Koh, Juhyun Son, Moonki Jung, Sangyun Oh, Sung-Jae Kim, Sung-Hwan Kim
The posterolateral corner (PLC) structures including the popliteofibular ligament (PFL), popliteus tendon (PT) and lateral collateral ligament (LCL) are important soft tissues for posterior translational, external rotational and varus angulation knee joint instabilities. The purpose of this study was to determine the effects of deficient PLC structures on the kinematics of the knee joint under gait and squat loading conditions. We developed subject-specific computational models with full 12-degree-of-freedom tibiofemoral and patellofemoral joints for four male subjects and one female subject...
February 13, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Jiyoung Park, Yonghwan Choi, Junghyun Namkung, Sung Gon Yi, Hyunsoo Kim, Jiyoung Yu, Yongkang Kim, Min-Seok Kwon, Wooil Kwon, Do-Youn Oh, Sun-Whe Kim, Seung-Yong Jeong, Wonshik Han, Kyu Eun Lee, Jin Seok Heo, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Chang Moo Kang, Woo Jin Lee, Seungyeoun Lee, Sangjo Han, Taesung Park, Jin-Young Jang, Youngsoo Kim
[This corrects the article DOI: 10.18632/oncotarget.21861.].
January 12, 2018: Oncotarget
Mi Hee Lim, Hyung Gon Je, Sang Kwon Lee
We report the case of a patient with mitral regurgitation complicated by type B dissection and Marfan syndrome (MFS) who was managed successfully with minimally invasive mitral valve repair. Without type A aortic dissection or aortic root dilation, MFS patients may develop mitral valve regurgitation, as in this case, and need valve surgery to improve their symptoms and long-term survival. However, it is not clear that a full sternotomy and prophylactic aortic surgery are necessary. Although retrograde perfusion to the dissected aorta is controversial, our approach minimizes the risk of future anticipated aortic surgery in MFS patients...
February 2018: Korean Journal of Thoracic and Cardiovascular Surgery
Jee-Yeon Seo, Yong-Hyun Ko, Shi-Xun Ma, Bo-Ram Lee, Seok-Yong Lee, Choon-Gon Jang
The studies for the effects of stress on drug addiction were mostly obtained using sequential exposure to stress and drugs. However, few studies have been conducted on the effects of simultaneous exposure to stress and methamphetamine (METH) on METH-induced reward effects and behavioral sensitization. Thus, we examined the effects of simultaneous exposure to restraint stress and METH on METH-induced addictive behaviors using conditioned place preference (CPP) in mice. During the conditioning period, the mice were exposed to 2 h restraint stress before administration of METH or saline for 4 days...
February 5, 2018: Brain Research Bulletin
Hehui Zhang, Xiaokai Yang, Yijun Lin, Linglong Chen, Hua Ye
Greater occipital nerve (GON) block has some potential in treating migraine. We conduct a systematic review and meta-analysis to investigate the impact of GON block on pain management of migraine. We have systematically searched randomized controlled trials (RCTs) assessing the efficacy of GON block versus placebo for migraine in various databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases. The primary outcome is pain intensity. Meta-analysis is performed using the random-effect model...
February 2018: Clinical Neurology and Neurosurgery
Dong Wook Shin, Sohyun Chun, Young Il Kim, Seung Joon Kim, Jung Soo Kim, SeMin Chong, Young Sik Park, Sang-Yun Song, Jin Han Lee, Hee Kyung Ahn, Eun Young Kim, Sei Hoon Yang, Myoung Kyu Lee, Deog Gon Cho, Tae Won Jang, Ji Woong Son, Jeong-Seon Ryu, Moon-June Cho
Lung cancer specialists play an important role in designing and implementing lung cancer screening. We aimed to describe their 1) attitudes toward low-dose lung computed tomography (LDCT) screening, 2) current practices and experiences of LDCT screening and 3) attitudes and opinions towards national lung cancer screening program (NLCSP). We conducted a national web-based survey of pulmonologists, thoracic surgeons, medical oncologists, and radiological oncologists who are members of Korean Association for Lung Cancer (N = 183)...
2018: PloS One
Baek-Lok Oh, Jeong Seok Lee, Eun Young Lee, Hee Young Lee, Hyeong Gon Yu
BACKGROUND: Anterior uveitis is the most common extra-articular manifestation of ankylosing spondylitis (AS). AS-related anterior uveitis frequently presents as acute, recurrent iridocyclitis; therefore, AS is often initially suspected by an ophthalmologist, not by a rheumatologist. In this study, we aimed to investigate the relationship between the recurrence of anterior uveitis and the subsequent incidence of AS. METHODS: From a national sample cohort, 10,483 patients with new-onset uveitis between 2004 and 2013 and 52415 matched control subjects who had never experienced uveitis were selected...
February 7, 2018: Arthritis Research & Therapy
Ryong Nam Kim, Hyeong-Gon Moon, Wonshik Han, Dong-Young Noh
Next generation sequencing has accelerated the discovery of a variety of new fusion gene types in clinical breast cancer samples by analyzing cancer genomes and transcriptomes. Although previous studies have focused on a few clinically validated oncogenic fusion genes as diagnostic and therapeutic targets in breast cancer, a perspective consideration has not been given thus far for a plethora of breast cancer fusion genes, which are being newly identified at an overwhelmingly increasing pace. In this perspective review, we discuss diverse fusion gene types recently identified in a variety of breast cancer subtypes, including breast clinical cancer samples in TCGA (The Cancer Genome Atlas) database...
February 7, 2018: International Journal of Molecular Sciences
Chun-Chia Cheng, Kuei-Fang Chou, Cheng-Wen Wu, Nai-Wen Su, Cheng-Liang Peng, Ying-Wen Su, Jungshan Chang, Ai-Sheng Ho, Huan-Chau Lin, Caleb Gon-Shen Chen, Bi-Ling Yang, Yu-Cheng Chang, Ya-Wen Chiang, Ken-Hong Lim, Yi-Fang Chang
OBJECTIVES: YM155, an inhibitor of interleukin enhancer-binding factor 3 (ILF3), significantly suppresses cancer stemness property, implying that ILF3 contributes to cell survival of cancer stem cells. However, the molecular function of ILF3 inhibiting cancer stemness remains unclear. This study aimed to uncover the potential function of ILF3 involving in cell survival of epidermal growth factor receptor (EGFR)-positive lung stem-like cancer, and to investigate the potential role to improve the efficacy of anti-EGFR therapeutics...
February 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Hyung Gon Shin, Hyong Seo Yoon, Jin Sung Kim, Minju Kim, June Yeong Lim, Sanghyuck Yu, Ji Hoon Park, Yeonjin Yi, Taekyeong Kim, Seong Chan Jun, Seongil Im
Van der Waals (vdW) Schottky junction between two dimensional (2D) transition metal dichalcogenides (TMDs) is introduced here for both vertical and in-plane current devices: Schottky diodes and metal semiconductor field effect transistors (MESFETs). The Schottky barrier between conducting NbS2 and semiconducting n-MoS2 appeared as large as ~0.5 eV due to their work function difference. While Schottky diode shows an ideality factor of 1.8~4.0 with ON/OFF current ratio of 103~105, Schottky effect MESFET displays little gate hysteresis and ideal subthreshold swing of 60~80 mV/dec due to low density traps at the vdW interface...
February 5, 2018: Nano Letters
Hidetoshi Gon, Yuya Nogi, Jun Arima, Daiki Okamoto, Masataka Fujikawa, Naoki Urakawa, Atsushi Takebe, Makoto Shinzeki, Kenichi Tanaka
A 72-year-old man underwent endoscopic submucosal dissection for early gastric cancer at antrum in July 2015. The histopathological examination revealed an adenocarcinoma invading the deep submucosal layer(SM2)with lymphatic invasion, consistent with the diagnosis of non-curative resection. Additional surgery was recommended, and he underwent laparoscopic distal gastrectomy in August 2015. The histopathological examination of resected specimen revealed there were no lymph node metastases, and postoperative diagnosis was Stage I A...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Bum-Joo Cho, Dong Yoon Kim, Un Chul Park, Joo Yong Lee, Young Hee Yoon, Hyeong Gon Yu
PURPOSE: To compare the clinical features and treatment outcomes of different types of vitreoretinal lymphoma (VRL) that presents primarily, secondarily, or concurrently in association with CNS lymphoma. METHODS: We retrospectively reviewed the medical records of 53 patients with VRL pathologically confirmed between 2000 and 2014 in two of the largest tertiary hospitals in Korea. RESULTS: The proportions of primary, secondary, and concurrent VRL were 26%, 34%, and 40%, respectively...
February 2, 2018: Ocular Immunology and Inflammation
Seong-Gon Kim
No abstract text is available yet for this article.
December 2018: Maxillofacial Plastic and Reconstructive Surgery
Cheul Muu Sim, Bong Jae Seong, Dong Won Kim, Yong Bum Kim, Seung Gon Wi, Gyuil Kim, Hwasuk Oh, TaeJoo Kim, Byung Yeoup Chung, Jeong Young Song, Hong Gi Kim, Sang-Keun Oh, Young Dol Shin, Jea Hwan Seok, Min Young Kang, Yunhee Lee, Mabuti Jacob Radebe, Nikolay Kardjilov, Bernd Honermeier
Various medicinal plants are threatened with extinction owing to their over-exploitation and the prevalence of soil borne pathogens. In this study, soils infected with root-rot pathogens, which prevent continuous-cropping, were treated with an electron beam. The level of soil-borne fungus was reduced to ≤0.01% by soil electron beam treatment without appreciable effects on the levels of antagonistic microorganism or on the physicochemical properties of the soil. The survival rate of 4-year-old plant was higher in electron beam-treated soil (81...
February 1, 2018: Scientific Reports
Sirui Jiang, Priya Nandy, Wenzhang Wang, Xiaopin Ma, Jeffrey Hsia, Chunyu Wang, Zhenlian Wang, Mengyue Niu, Sandra L Siedlak, Sandy Torres, Hisashi Fujioka, Ying Xu, Hyoung-Gon Lee, George Perry, Jun Liu, Xiongwei Zhu
BACKGROUND: Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD). It is believed that mitochondrial fragmentation, due to impaired fission and fusion balance, likely causes mitochondrial dysfunction that underlies many aspects of neurodegenerative changes in AD. Mitochondrial fission and fusion proteins play a major role in maintaining the health and function of these important organelles...
February 1, 2018: Molecular Neurodegeneration
Min Hwan Kim, Chang Gon Kim, Sang-Kyum Kim, Sang Joon Shin, Eun Ah Choe, Su-Hyung Park, Eui-Cheol Shin, Joon Kim
Activation of YAP, a Hippo pathway effector, is an important resistance mechanism to BRAF inhibitor (BRAFi) in melanoma. Emerging evidence also suggests that YAP is involved in suppression of the antitumor immune response. However, the potential direct impact of YAP activity on cytotoxic T-cell immune responses has not been explored yet. Here, we show that BRAFi-resistant melanoma cells evade CD8+ T-cell immune responses in a PD-L1-dependent manner by activating YAP, which synchronously supports melanoma cell survival upon BRAF inhibition...
January 30, 2018: Cancer Immunology Research
Bhagwan Sahebrao Batule, Seong U Kim, Hyoyoung Mun, Changsun Choi, Won-Bo Shim, Min-Gon Kim
Worldwide, norovirus (NV) is one of the most associated cause of acute gastroenteritis, which leads nearly 50,000 child deaths every year in developing countries. Therefore, there is great demand to develop rapid, low-cost, and accurate detection assay for the foodborne norovirus infection in order to reduce mortality caused by norovirus. Considering importance of norovirus, we have demonstrated a highly sensitive and specific colorimetric detection method for analysis of human norovirus genogroups I and II (HuNoV GI and II) in oyster samples...
January 30, 2018: Journal of Agricultural and Food Chemistry
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