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József Kun, Anikó Perkecz, Lorenz Knie, György Sétáló, Tamás Tornóczki, Erika Pintér, Ágnes Bán
OBJECTIVE: Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with antigen-specific and non-specific mechanisms. Transient Receptor Potential Ankyrin 1 (TRPA1) is a non-selective cation channel activated by noxious stimuli such as oxidative stress products evoking pain and release of proinflammatory mediators from sensory nerve endings culminating in neurogenic inflammation. Extraneuronal TRPA1s e.g. on immune cells possess yet unkown functions. SUBJECTS AND METHODS: We studied the buccal mRNA expression (qPCR) and protein localization (immunohistochemistry) of TRPA1 receptors, and key OLP mediator transcripts in oral mucosa samples of healthy volunteers (n=9), OLP patients (n=43) and OLP-like hyperkeratotic diseases (n=12)...
October 8, 2016: Oral Diseases
Marco Witkowski, Hans-Christian Mochmann, Ursula Rauch, Wulf Knie, Ulf Landmesser, Carsten Skurk
No abstract text is available yet for this article.
October 2016: Critical Care Medicine
G Hartmann, A O Lindahl, A Knie, N Hartmann, A A Lutman, J P MacArthur, I Shevchuk, J Buck, A Galler, J M Glownia, W Helml, Z Huang, N M Kabachnik, A K Kazansky, J Liu, A Marinelli, T Mazza, H-D Nuhn, P Walter, J Viefhaus, M Meyer, S Moeller, R N Coffee, M Ilchen
A non-destructive diagnostic method for the characterization of circularly polarized, ultraintense, short wavelength free-electron laser (FEL) light is presented. The recently installed Delta undulator at the LCLS (Linac Coherent Light Source) at SLAC National Accelerator Laboratory (USA) was used as showcase for this diagnostic scheme. By applying a combined two-color, multi-photon experiment with polarization control, the degree of circular polarization of the Delta undulator has been determined. Towards this goal, an oriented electronic state in the continuum was created by non-resonant ionization of the O2 1s core shell with circularly polarized FEL pulses at hν ≃ 700 eV...
August 2016: Review of Scientific Instruments
Bettina Knie, Nobuhito Morota, Satoshi Ihara, Goichiro Tamura, Hideki Ogiwara
PURPOSE: The aim of this study is for the surgical treatment and outcome of the endoscopic fenestration of the arachnoid cyst located in the ventricular body to trigone in the pediatric population. Special concern was paid for the developmental origin of the intraventricular cysts estimated from the postoperative follow-up neuroimagings. PATIENTS AND METHODS: Between July 2002 and June 2015, we performed endoscopic and partly CT/MRI navigated fenestrations of intraventricular arachnoid cysts located at the body to trigone of the lateral ventricle in ten pediatric patients aged 2 months to 5 years...
August 4, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Simon Maria Zumkeller, Volker Knoop, Nils Knie
Mitochondrial intron patterns are highly divergent between the major land plant clades. An intron in the atp1 gene, atp1i361g2, is an example for a group II intron specific to monilophytes (ferns). Here, we report that atp1i361g2 is lost independently at least 4 times in the fern family Pteridaceae. Such plant organelle intron losses have previously been found to be accompanied by loss of RNA editing sites in the flanking exon regions as a consequence of genomic recombination of mature cDNA. Instead, we now observe that RNA editing events in both directions of pyrimidine exchange (C-to-U and U-to-C) are retained in atp1 exons after loss of the intron in Pteris argyraea/biaurita and in Actiniopteris and Onychium We find that atp1i361g2 has significant similarity with intron rps3i249g2 present in lycophytes and gymnosperms, which we now also find highly conserved in ferns...
2016: Genome Biology and Evolution
Kamlesh Kumar, Christopher Knie, David Bléger, Mark A Peletier, Heiner Friedrich, Stefan Hecht, Dirk J Broer, Michael G Debije, Albertus P H J Schenning
Nature provides much inspiration for the design of materials capable of motion upon exposure to external stimuli, and many examples of such active systems have been created in the laboratory. However, to achieve continuous motion driven by an unchanging, constant stimulus has proven extremely challenging. Here we describe a liquid crystalline polymer film doped with a visible light responsive fluorinated azobenzene capable of continuous chaotic oscillatory motion when exposed to ambient sunlight in air. The presence of simultaneous illumination by blue and green light is necessary for the oscillating behaviour to occur, suggesting that the dynamics of continuous forward and backward switching are causing the observed effect...
2016: Nature Communications
Nils Knie, Felix Grewe, Volker Knoop
Intron patterns in plant mitochondrial genomes differ significantly between the major land plant clades. We here report on a new, clade-specific group II intron in the rps1 gene of monilophytes (ferns). This intron, rps1i25g2, is strikingly similar to rpl2i846g2 previously identified in the mitochondrial rpl2 gene of seed plants, ferns, and the lycophyte Phlegmariurus squarrosus Although mitochondrial ribosomal protein genes are frequently subject to endosymbiotic gene transfer among plants, we could retrieve the mitochondrial rps1 gene in a taxonomically wide sampling of 44 monilophyte taxa including basal lineages such as the Ophioglossales, Psilotales, and Marattiales with the only exception being the Equisetales (horsetails)...
September 2016: RNA
Nils Knie, Felix Grewe, Simon Fischer, Volker Knoop
BACKGROUND: RNA editing by C-to-U conversions is nearly omnipresent in land plant chloroplasts and mitochondria, where it mainly serves to reconstitute conserved codon identities in the organelle mRNAs. Reverse U-to-C RNA editing in contrast appears to be restricted to hornworts, some lycophytes, and ferns (monilophytes). A well-resolved monilophyte phylogeny has recently emerged and now allows to trace the side-by-side evolution of both types of pyrimidine exchange editing in the two endosymbiotic organelles...
2016: BMC Evolutionary Biology
A Knie, M Patanen, A Hans, I D Petrov, J D Bozek, A Ehresmann, Ph V Demekhin
In the angle-averaged excitation and decay spectra of molecules, vibronic coupling may induce the usually weak dipole-forbidden transitions by the excitation intensity borrowing mechanism. The present complementary theoretical and experimental study of the resonant Auger decay of core-to-Rydberg excited CH_{4} and Ne demonstrates that vibronic coupling plays a decisive role in the formation of the angle-resolved spectra by additionally involving the decay rate borrowing mechanism. Thereby, we propose that the angle-resolved Auger spectroscopy can in general provide very insightful information on the strength of the vibronic coupling...
May 13, 2016: Physical Review Letters
L Fimiani, D L Cook, T Faestermann, J M Gómez-Guzmán, K Hain, G Herzog, K Knie, G Korschinek, P Ludwig, J Park, R C Reedy, G Rugel
A dying massive star ends in a supernova explosion ejecting a large fraction of its mass into the interstellar medium. If this happens nearby, part of the ejecta might end on Solar System bodies and, in fact, radioactive ^{60}Fe has been detected on the Pacific ocean floor in about 2 Ma old layers. Here, we report on the detection of this isotope also in lunar samples, originating presumably from the same event. The concentration of the cosmic ray produced isotope ^{53}Mn, measured in the same samples, proves the supernova origin of the ^{60}Fe...
April 15, 2016: Physical Review Letters
B Knie, M Plotkin, P Zschieschang, V Prasad, D Moskopp
AIM: Hereditary pheochromocytoma-paraganglioma syndromes are characterized by multiple pheochromocytomas (PCC) and paragangliomas (PGLs), inherited in an autosomal dominant manner. Early detection and removal of tumours may prevent or minimize complications related to mass effects and malignant transformation. Having confirmed the diagnosis, it is important to localize the tumours and reveal their extent preoperatively. This study aimed to introduce 18F-DOPA PET/CT as a highly sensitive non-invasive diagnostic tool for early detection of mass lesions in patients with pheochromocytoma-paraganglioma inherited tumour syndrome and to report about its impact on patient management...
2016: Nuklearmedizin. Nuclear Medicine
Marco Witkowski, Hans-Christian Mochmann, Ursula Rauch, Wulf Knie, Ulf Landmesser, Carsten Skurk
OBJECTIVE: To report a case of intra-arterial amiodarone injection in a hemodynamically unstable patient leading to acute vessel occlusion and a subsequent compartment syndrome. DESIGN: Case report. SETTING: Prehospital setting, emergency department and ICU of a university hospital. PATIENT: A 58-year-old woman presenting with a ventricular tachycardia of 190 beats/min was administered amiodarone through an accidently placed arterial access in the left cubital fossa...
April 2016: Critical Care Medicine
Nils Knie, Simon Fischer, Felix Grewe, Monika Polsakiewicz, Volker Knoop
The "Monilophyte" clade comprising ferns, horsetails and whisk ferns receives unequivocal support from molecular data as the sister clade to seed plants. However, the branching order of its earliest emerging lineages, the Equisetales (horsetails), the Marattiales, the Ophioglossales/Psilotales and the large group of leptosporangiate ferns has remained dubious. We investigated the mitochondrial nad2 and rpl2 genes as two new, intron-containing loci for a wide sampling of taxa. We found that both group II introns - nad2i542g2 and rpl2i846g2 - are universally present among monilophytes...
September 2015: Molecular Phylogenetics and Evolution
A Wallner, T Faestermann, J Feige, C Feldstein, K Knie, G Korschinek, W Kutschera, A Ofan, M Paul, F Quinto, G Rugel, P Steier
Half of the heavy elements including all actinides are produced in r-process nucleosynthesis, whose sites and history remain a mystery. If continuously produced, the Interstellar Medium is expected to build-up a quasi-steady state of abundances of short-lived nuclides (with half-lives ≤100 My), including actinides produced in r-process nucleosynthesis. Their existence in today's interstellar medium would serve as a radioactive clock and would establish that their production was recent. In particular (244)Pu, a radioactive actinide nuclide (half-life=81 My), can place strong constraints on recent r-process frequency and production yield...
2015: Nature Communications
Nils Knie, Monika Polsakiewicz, Volker Knoop
Mitochondrial genomes of lycophytes are surprisingly diverse, including strikingly different transfer RNA (tRNA) gene complements: No mitochondrial tRNA genes are present in the spikemoss Selaginella moellendorffii, whereas 26 tRNAs are encoded in the chondrome of the clubmoss Huperzia squarrosa. Reinvestigating the latter we found that trnL(gag) and trnS(gga) had never before been identified in any other land plant mitochondrial DNA. Sensitive sequence comparisons showed these two tRNAs as well as trnN(guu) and trnS(gcu) to be very similar to their respective counterparts in chlamydial bacteria...
March 2015: Molecular Biology and Evolution
Christopher Knie, Manuel Utecht, Fangli Zhao, Hannes Kulla, Sergey Kovalenko, Albert M Brouwer, Peter Saalfrank, Stefan Hecht, David Bléger
Improving the photochemical properties of molecular photoswitches is crucial for the development of light-responsive systems in materials and life sciences. ortho-Fluoroazobenzenes are a new class of rationally designed photochromic azo compounds with optimized properties, such as the ability to isomerize with visible light only, high photoconversions, and unprecedented robust bistable character. Introducing σ-electron-withdrawing F atoms ortho to the NN unit leads to both an effective separation of the n→π* bands of the E and Z isomers, thus offering the possibility of using these two transitions for selectively inducing E/Z isomerizations, and greatly enhanced thermal stability of the Z isomers...
December 8, 2014: Chemistry: a European Journal
Zhenxiang Zhang, Beibei Gu, Wei Zhu, Lixian Zhu, Qingsong Li, Yaqing Du
OBJECTIVE: The aim of this prospective, randomized study was to compare the clinical results of arthroscopic single-bundle (SB) and triple-bundle (TB) anterior cruciate ligament (ACL) reconstruction. METHODS: The study included 105 patients who underwent arthroscopic SB ACL and TB ACL reconstruction. Anterior stress radiographs and the maximal manual muscle test using a KT-2000 arthrometer were used to assess anteroposterior stability and rotational stability was investigated using the lateral pivot shift test at the 24th month follow-up...
2014: Acta Orthopaedica et Traumatologica Turcica
Han-Jun Lee, Yong-Beom Park, Young-Bong Ko, Seong-Hwan Kim, Hyeok-Bin Kwon, Dong-Seok Yu, Young-Bok Jung
PURPOSE: The purpose of this study was to evaluate the usefulness of tibial reduction during dial test for clinical detection of underestimated posterolateral rotatory instability (PLRI) in combined posterior cruciate ligament (PCL)-posterolateral corner (PLC) deficient knee in terms of external rotation laxity and clinical outcomes. METHODS: Twenty-one patients who classified as grade I PLRI using dial test with subluxated tibia, but classified as grade II with tibial reduction evaluated retrospectively...
October 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Christoph Abels, Hubert Reich, Ulrich Knie, Dieter Werdier, Gunter Lemmnitz
BACKGROUND: Cleansing products for acne should remove excessive sebum, reduce acne-related bacteria and improve inflammation. AIMS: The aim of the study was to investigate a topical cleansing product containing glycolic acid with pH 4 in mild acne vulgaris. METHODS: Sixty patients were recruited for this open uncontrolled clinical trial. The tested product was exclusively applied twice a day for 6 weeks. The efficacy was judged by a dermatologist according to the Leeds score after 3 and 6 weeks...
June 2014: Journal of Cosmetic Dermatology
M Ilchen, L Glaser, F Scholz, P Walter, S Deinert, A Rothkirch, J Seltmann, J Viefhaus, P Decleva, B Langer, A Knie, A Ehresmann, O M Al-Dossary, M Braune, G Hartmann, A Meissner, L C Tribedi, M AlKhaldi, U Becker
In quantum mechanics the Young-type double-slit experiment can be performed with electrons either traveling through a double slit or being coherently emitted from two inversion symmetric molecular sites. In the latter one the valence photoionization cross sections of homonuclear diatomic molecules were predicted to oscillate over kinetic energy almost 50 years ago. Beyond the direct proof of the oscillatory behavior of these photoionization cross sections σ, we show that the angular distribution of the emitted electrons reveals hitherto unexplored information on the relative phase shift between the corresponding partial waves through two-center interference patterns...
January 17, 2014: Physical Review Letters
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