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Vit D 3

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https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#1
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette D LaMarca
Autoantibodies to the angiotensin II (ANGII) type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that Vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined if the decrease in AT1-AA was the mechanism whereby Vitamin D lowered MAP or if it was through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1 and sFlt-1 are increased with AT1-AA induced hypertension and considered markers of PE in pregnant women...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27863277/vitamin-d-supplementation-affects-the-igf-system-in-men-after-acute-exercise
#2
Rachel L Darr, Kathleen J Savage, Mark Baker, Gregory E Wilding, Amy Raswalsky, Todd Rideout, Richard W Browne, Peter J Horvath
OBJECTIVE: Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system. DESIGN: D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit...
November 5, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27847277/influence-of-surfactants-on-depsipeptide-submicron-particle-formation
#3
Nadia Brunacci, Christian Wischke, Toufik Naolou, Axel T Neffe, Andreas Lendlein
Surfactants are required for the formation and stabilization of hydrophobic polymeric particles in aqueous environment. In order to form submicron particles of varying sizes from oligo[3-(S)-sec-butylmorpholine-2,5-dione]diols ((OBMD)-diol), different surfactants were investigated. As new surfactants, four-armed star-shaped oligo(ethylene glycol)s of molecular weights of 5-20kDa functionalized with desamino-tyrosine (sOEG-DAT) resulted in smaller particles with lower PDI than with desaminotyrosyl tyrosine (sOEG-DATT) in an emulsion/solvent evaporation method...
November 12, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27769784/vitamin-d3-supplementation-among-adult-patients-with-cystic-fibrosis
#4
Adèle Coriati, Évelyne Labrèche, Marjolaine Mailhot, Hortensia Mircescu, Yves Berthiaume, Annick Lavoie, Rémi Rabasa-Lhoret
BACKGROUND & AIMS: Vitamin D (Vit D) deficiency in cystic fibrosis (CF) is partially secondary to exocrine pancreatic insufficiency. Our aim was to establish a Vit D3 supplementation protocol that will increase 25(OH)D to the recommended level (30 ng/mL). METHODS: Retrospective study of 200 patients (≥18 years) conducted from February 2007 to June 2014 at the CF clinic of the Centre Hospitalier de l'Université de Montréal. Vit D3 supplementation protocol was 1600 IU/day or 10,000 IU/week during the summer (May 1st to October 31st) and 3200 IU/day or 20,000 IU/week during the winter (November 1st to April 30th), in addition to the 1200 IU/day included in multivitamins...
October 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27729974/acetylsalicylic-acid-supplementation-improves-protein-utilization-efficiency-while-vitamin-e-supplementation-reduces-markers-of-the-inflammatory-response-in-weaned-pigs-challenged-with-enterotoxigenic-e-coli
#5
Jae Cheol Kim, Bruce P Mullan, John L Black, Robert J E Hewitt, Robert J van Barneveld, John R Pluske
BACKGROUND: This experiment was conducted to test the hypothesis that vitamin E (Vit E) and acetylsalicylic acid (ASA), a cyclooxygenase-2 (COX-2) inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E2 (PGE2) and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. coli. METHODS: The experiment was conducted in a research facility with 192 individually-housed male weaner pigs (Landrace × Large White) weighing 6...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27720520/three-dimensional-ultrasound-guided-real-time-midline-epidural-needle-placement-with-epiguide-a-prospective-feasibility-study
#6
Parmida Beigi, Paul Malenfant, Abtin Rasoulian, Robert Rohling, Alison Dube, Vit Gunka
Current 2-D ultrasound technology is unable to perform a midline neuraxial needle insertion under real-time ultrasound guidance using a standard needle and without an assistant. The aim of the work described here was to determine the feasibility of a new technology providing such capability, starting with a study evaluating the selected puncture site. A novel 3-D ultrasound imaging technique was designed using thick-slice rendering in conjunction with a custom needle guide (3DUS + Epiguide). A clinical feasibility study evaluated the ability of 3DUS + Epiguide to identify the epidural needle puncture site for a midline insertion in the lumbar spine...
January 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27650228/vitamin-d-supplementation-not-so-simple-in-sarcoidosis
#7
Amik Sodhi, Thomas Aldrich
INTRODUCTION: Americans are increasingly receiving vitamin D supplementation, often based on low-measured 25-hydroxy-vitamin D (25-OH-vit D). In sarcoidosis, there is often increased metabolism of 25-OH-vit D to 1,25-dihydroxy-vitamin D (1,25-OH-vit D), so 25-OH-vit D may remain low, despite high levels of 1,25-OH-vit D. In such cases, vitamin D supplementation may lead to hypercalcemia. METHODS: We randomly selected 196 patients with sarcoidosis who received at least 1 prescription of vitamin D between 2005 and 2011 and 196 control patients...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27616756/vitamin-d-levels-vitamin-d-supplementation-and-prognosis-in-patients-with-chronic-kidney-disease%C3%A2
#8
Yossef Namir, Matan J Cohen, Yosef S Haviv, Itzchak Slotki, Linda Shavit
BACKGROUND: Vitamin D (Vit D) deficiency plays a central role in the pathogenesis of chronic kidney disease (CKD) complications, both skeletal and nonskeletal. The purpose of this study was to examine whether 25(OH)D levels and supplementation with oral cholecalciferol (Vitamin D3 (Vit D3)) are associated with morbidity and mortality among patients with significant CKD. METHODS: CKD patients attending the nephrology clinic at Shaare Zedek Medical Center between July 1, 2008 and January 31, 2012, tested at least twice for 25(OH)D levels, were enrolled...
October 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27605743/current-scenario-of-prevalence-of-vitamin-d-deficiency-in-ostensibly-healthy-indian-population-a-hospital-based-retrospective-study
#9
Kirtikar Shukla, Shikha Sharma, Aditi Gupta, Arun Raizada, Kamini Vinayak
25-hydroxy vitamin D [25(OH) vit D] deficiency is a serious public health problem, particularly in the Indian sub-continent. The objective of the present study was to study the prevalence of 25(OH) vit D in different age groups. The data of 25(OH) vit D assay of 26,346 ostensibly healthy individuals, enrolled under executive health checkup at Medanta The Medicity, Gurgaon, over a period of 3 years, were extracted from the hospital information system and reviewed extensively. 25(OH) vit D deficiency (VDD) was defined as 25(OH) vit D < 20 ng/ml, insufficiency (VDI) as 25(OH) vit D between 20 and 40 ng/ml and 25(OH) vit D sufficiency (VDS) as 25(OH) D > 40 ng/mL...
October 2016: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/27574411/plasma-homocysteine-level-is-a-risk-factor-for-osteoporotic-fractures-in-elderly-patients
#10
Yuefeng Zhu, Jie Shen, Qun Cheng, Yongqian Fan, Weilong Lin
OBJECTIVE: To study the relationship of plasma homocysteine (Hcy), bone turnover biomarkers (BTB), and bone mineral density (BMD) with osteoporotic fracture (OPF) in elderly people. METHODS: Eighty-two patients (aged 65 years or older) admitted to our orthopedics department between October 2014 and May 2015 were randomly divided into three groups: 1) OPF group: 39 cases with the mean age 81.82±5.49 years, which included 24 females and 15 males; 2) high-energy fracture (HEF) group: 22 cases with the mean age 78...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27560913/-influence-of-serum-levels-of-vitamin-d-on-ige-response-in-schoolchildren-with-asthma-in-poor-communities
#11
Eduardo Egea, Gloria Garavito, Luis Fang, Dary Luz Mendoza, José Miguel Escamilla, Elsie De Los Ríos, Rodolfo Dennis, Mario Sánchez-Borges
BACKGROUND: Asthma is a common disease in the world and vitamin D (Vit-D) has been associated with the presence and severity of this disease. OBJECTIVE: To establish the association between levels of Vit-D and IgE response in schoolchildren with asthma living in four cities in Colombia. METHODS: Case-control study in 1340 schoolchildren (687 asthmatic and 653 controls) from communities in extreme poverty in Barranquilla, Cartagena, Santa Marta, and Montería...
July 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27476528/prevalence-of-vitamin-d-deficiency-and-calcium-homeostasis-in-saudi-children-and-adolescents
#12
Adnan M Al Shaikh, Bahaa Abaalkhail, Ashraf Soliman, Ibrahim Kaddam, Khalid Aseri, Yousef Al Saleh, Ali Al Qarni, Ahmed Al Shuaibi, Waleed Al Tamimi, Abdel Moniem Mukhtar
OBJECTIVE: Vitamin D deficiency (VDD) and insufficiency (VDI) are significant health problem all-over the world. The aim of this study was to determine the prevalence of VDD and VDI in children and adolescents residing in 8 provinces in the Kingdom of Saudi Arabia (KSA) and to investigate their calcium homeostasis. METHODS: A cross-sectional study with 2110 participants aged between 6 and 15 years were enrolled. The questionnaire included personal and socio-demographic, anthropometric measurements, knowledge about vitamin D, color of the skin, dietary intake, sun exposure experience, smoking, and physical activity...
July 30, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27475773/serum-vitamin-d-levels-decrease-in-children-with-acute-urticaria
#13
B Ozdemir, B T Köksal, N M Karakaş, O Y Ozbek
BACKGROUND: Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders. OBJECTIVE: The aim of this study was to evaluate serum vitamin D levels in acute urticaria. METHODS: We enrolled 30 children with acute urticaria and 30 control subjects. Concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status, were measured in serum of acute urticaria patients and compared with the control group...
July 27, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27416038/how-is-the-relation-between-endocrine-changes-and-bone-markers-in-pediatric-thalassemic-patients-after-hematopoietic-stem-cell-transplantation
#14
Amir A Hamidieh, Zohreh Hamidi, Maryam Behfar, Zeinab Pajouhi, Kamran Alimoghaddam, Fariba Mohseni, Ardeshir Ghavamzadeh, Maryam Sobhani, Bagher Larijani, Mohammad R Mohajeri Tehrani
BACKGROUNDS: Beta Thalassemia Major, and its treatment by hematopoietic stem cell transplantation can have deleterious effect on bone integrity and a main part of such effects is due to their deleterious effects on endocrine systems. So, we assessed the effects of endocrine changes during HSCT (Hematopoietic Stem Cell Transplantation) on growing bones of pediatric thalassemic patients. METHODS: Bone-specific alkaline phosphatase and osteocalcin (bone formation markers), NTX (bone resorption marker), Ca, P, Alk ph, PTH, Vitamin D (vit D), prolactin, LH, FSH, T4, T3, TSH, IGF-1, testosterone (in males) or estradiol (in females), measured in 20 major thalassemic patients with mean age of 10...
July 14, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27374925/analysis-of-the-safety-and-tolerance-of-three-buildup-protocols-of-insect-venom-immunotherapy-frequently-used-in-spain
#15
D Gutiérrez Fernández, A Moreno-Ancillo, S Fernández Meléndez, C Domínguez-Noche, P Gálvez Ruiz, T Alfaya Arias
INTRODUCTION: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk as both local and systemic adverse reactions may occur especially in the initial stages of treatment. We compared the tolerance to three buildup protocols of VIT and analyzed risk factors associated with adverse reactions occurring in this phase. METHODS: We enrolled 165 patients divided into three groups based on the buildup protocol used (3, 4, 9 weeks). Severity of systemic reactions was evaluated according to World Allergy Organization model...
April 19, 2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27049271/evaluation-of-serum-vitamin-d-levels-in-patients-with-x-syndrome
#16
F N Turhan Caglar, I Ungan, V Ksanski, S Opan, S Çiftçi, A Kural, A Koyuncu, F Akturk, O Karakaya
OBJECTIVE: Cardiac X syndrome is defined in patients with normal coronary angiogram who has typical chest pain and objective myocardial ischemia evidence. Recent studies have evaluated the association between vitamin D deficiency (vit D def) and cardiovascular diseases. Our aim of this study was to compare serum vit D levels in patients with syndrome X and controls. PATIENTS AND METHODS: We included 66 patients (49 women, 17 men) with syndrome X and 47 (30 women, 17 men) healthy controls...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27041085/probing-the-relation-between-vitamin-d-deficiency-and-progression-of-medial-femoro-tibial-osteoarthitis-of-the-knee
#17
Hassan Bassiouni, Hany Aly, Khaled Zaky, Nouran Abaza, Thomas Bardin
OBJECTIVE: To compare serum 25 OH vitamin D (25 (OH) D) levels between medial femoro-tibial knee osteoarthritis (OA) patients and controls, and to detect structural progression in patients with mild to moderate knee osteoarthritis in relation to baseline 25(OH) D levels in a one-year longitudinal prospective cohort study. METHODS: Thirty eight patients with medial femoro-tibial knee OA according to the ACR criteria and no knee malalignement, and 20 age, sex and BMI-matched pain free controls were included in the vitamin D study...
April 4, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27027966/vitamin-d-reduces-inflammation-induced-contractility-and-remodeling-of-asthmatic-human-airway-smooth-muscle
#18
Rodney D Britt, Michael A Thompson, Michelle R Freeman, Alecia L Stewart, Christina M Pabelick, Y S Prakash
BACKGROUND: Although multiple clinical studies have found an association between vitamin D (Vit D) deficiency and asthma, a recent clinical study suggested lack of therapeutic effect of Vit D supplementation. Nonetheless, the mechanisms by which Vit D influences airway structure and function in the context of inflammation and asthma remains undefined. In this regard, Vit D effects on airway smooth muscle (ASM) are important, given the role of this cell type in the hypercontractility and remodeling...
March 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/26995199/high-prevalence-of-hypovitaminosis-d-in-postmenopausal-women-with-type-2-diabetes-mellitus
#19
Ivan Raška, Mária Rašková, Vít Zikán, Jan Škrha
The link between vitamin D and type 2 diabetes mellitus (T2DM) is intensively studied. This study aims to define the serum concentration of 25-hydroxyvitamin D (25-OH D) and to investigate the relationship between 25-OH D status, glycated hemoglobin (HbA1c) and body composition in postmenopausal women with T2DM and in non-diabetic controls. In this cross-sectional study, 75 women with T2DM and 32 control subjects were selected. Serum 25-OH D, intact parathyroid hormone (PTH), calcium, fasting glucose and HbA1c, were measured...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/26975215/modulation-of-aquaporins-3-and-9-after-exposure-of-ovine-ovarian-tissue-to-cryoprotectants-followed-by-in-vitro-culture
#20
A D Sales, A B G Duarte, R R Santos, K A Alves, L F Lima, G Q Rodrigues, I R Brito, C H Lobo, J B Bruno, Y Locatelli, J R Figueiredo, A P R Rodrigues
Our aim has been to evaluate the effect of cryoprotective agents (CPAs) on the exposure, vitrification (VIT), and in vitro culture (IVC) of ovarian tissue with regard to the expression and immunolocalization of aquaporins (AQPs) 3 and 9 in ovine preantral follicles. Tissues were treated as follows: Experiment I: (1) control (without exposure to CPAs), (2) e-EG (exposure to ethylene glycol), (3) er-EG (exposure to and removal of EG), (4) e-DMSO (exposure to dimethyl sulfoxide), (5) er-DMSO (exposure to and removal of DMSO), (6) e-EG+DMSO (exposure to EG+DMSO), (7) er-EG+DMSO (exposure to and removal of EG+DMSO); Experiment II: (1) control, (2) VIT, (3) IVC, (4) VIT-IVC...
August 2016: Cell and Tissue Research
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