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Vit D 3

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https://www.readbyqxmd.com/read/29781720/supplementation-of-vitamin-d-deficiency-in-patients-with-neuroendocrine-tumors-using-over-the-counter-vitamin-d3-preparations
#1
Helen L Robbins, Megan Symington, Barbara Mosterman, Josie Goodby, Louise Davies, Georgios K Dimitriadis, Gregory Kaltsas, Harpal S Randeva, Martin O Weickert
Vitamin D (vit-D) deficiency is highly prevalent in patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NET) and has been linked to reduced overall survival. We here assessed the vit-D status in 183 patients with GEP-NET at the time of their first presentation in the ARDEN NET Centre. We further examined the effect of simple advice to increase vit-D intake using over-the-counter vit-D preparations [colecalciferol (Vit-D3), 1,000-2,000 units/day], over a prospective observation period of 24 mo...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29751936/effect-of-vitamin-d-on-the-variability-of-blood-pressure-in-premenopausal-and-menopausal-hypertensive-women-in-the-area-of-blida-algeria
#2
A Bachir Cherif, M Temmar, S Bennouar, A Bouamra, A Taleb, A Bouraghda, M T Bouafia
OBJECTIVE: To evaluate the effect of 25 (OH) vitamin D supplementation on blood pressure (BP) variability in hypertensive women in the pre-menopausal and post-menopausal periods. MATERIALS AND METHODS: 881 hypertensive women prospectively followed for an interventional study between January 2016 and September 2017, in specialized consultation at the department of internal medicine at the Blida University Hospital (Algeria). Four hundred and thiry nine premenopausal women (group I) and 442 menopausal women (group II)...
May 8, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29715453/role-of-wnt4-%C3%AE-catenin-ang-ii-tgf%C3%AE-ace2-nf-%C3%AE%C2%BAb-and-il-18-in-attenuating-renal-ischemia-reperfusion-induced-injury-in-rats-treated-with-vit-d-and-pioglitazone
#3
Rabab M Ali, Muhammad Y Al-Shorbagy, Maged W Helmy, Hanan S El-Abhar
Renal ischemia-reperfusion injury (I/RI) remains a critical clinical situation. Several evidence revealed the potential reno-protective effects of Vitamin D and/or pioglitazone, on renal I/RI. This study addresses the possible involvement of the Wnt4/β-catenin signaling, p-S536NF-κBp65, PPARγ, Ang II/TGF-β, and ACE2 as potential effectors to vitamin D and pioglitazone-mediated renoprotective effects. Two sets of Sprague-Dawley rats (n=30 rat each), were randomized into sham, I/R, Vit D "alfacalcidol" (5ng/kg/day), pioglitazone (5mg/kg/day), and Vit D + pioglitazone groups...
April 28, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29684027/chronic-calcitriol-supplementation-improves-the-inflammatory-profiles-of-circulating-monocytes-and-the-associated-intestinal-adipose-tissue-alteration-in-a-diet-induced-steatohepatitis-rat-model
#4
Yen-Bo Su, Tzu-Hao Li, Chia-Chang Huang, Hung-Cheng Tsai, Shiang-Fen Huang, Yun-Cheng Hsieh, Ying-Ying Yang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Vitamin D deficiency and up-regulated TNFα-related signals are reported to be involved in abnormalities including intestinal hyper-permeability, bacterial translocation, systemic/portal endotoxemia, intestinal/adipose tissue/hepatic inflammation, and hepatic steatosis in nonalcoholic steatohepatitis (NASH). This study aims to explore the molecular mechanisms and effects of chronic calcitriol [1,25-(OH)2D3, hormonal form of vitamin D] on gut-adipose tissue-liver axis abnormalities using a high-fat diet (HFD)-fed rat model of NASH...
2018: PloS One
https://www.readbyqxmd.com/read/29681950/vitamin-d-promotes-msc-osteogenic-differentiation-stimulating-cell-adhesion-and-%C3%AE-v-%C3%AE-3-expression
#5
Francesca Posa, Adriana Di Benedetto, Elisabetta A Cavalcanti-Adam, Graziana Colaianni, Chiara Porro, Teresa Trotta, Giacomina Brunetti, Lorenzo Lo Muzio, Maria Grano, Giorgio Mori
Vitamin D (Vit D) by means of its biological active form, 1 α ,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In this work, we present for the first time the effect of 1,25(OH)2 D3 on MSC adhesion. Considering that cell adhesion to the substrate is fundamental for cell commitment and differentiation, we focused on the expression of α V β 3 integrin, which has a key role in the commitment of MSCs to the osteoblastic lineage...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29619868/fibroblast-growth-factor-23-is-a-strong-predictor-of-insulin-resistance-among-chronic-kidney-disease-patients
#6
Ahmed Fayed, Mahmoud M El Nokeety, Ahmed A Heikal, Dina O Abdulazim, Mervat M Naguib, Usama A A Sharaf El Din
Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role in the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) is evolving as the most important link between MBD and many pathologic sequences of CKD. The aim was to evaluate IR in pre-dialysis CKD patients looking for a possible association to mineral metabolism among CKD patients. A total of 100 stage 3-5 CKD patients were selected beside 20 normal control subjects...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29608396/metabolic-syndrome-and-vitamin-d-levels-in-patients-with-obstructive-sleep-apnea-syndrome
#7
Kostas Archontogeorgis, Evangelia Nena, Nikolaos Papanas, Manfredi Rizzo, Athanasios Voulgaris, Maria Xanthoudaki, Maria Kouratzi, Georgia Ragia, Vangelis Manolopoulos, Athanasios Zissimopoulos, Marios Froudarakis, Paschalis Steiropoulos
BACKGROUND: Numerous studies have indicated that obstructive sleep apnea syndrome (OSAS), may contribute to the development of metabolic syndrome (MetS) and diabetes. Moreover, OSAS has been associated with lowered vitamin D (Vit D) levels, but reports are inconclusive. Aim of the study was to compare Vit D levels according to the presence of MetS and its components in OSAS patients. METHODS: The presence of MetS was evaluated and serum 25-hydroxy vitamin D [25(OH)D] levels were measured in consecutive newly diagnosed, by polysomnography, subjects with OSAS...
April 2, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29606435/vitamin-d-biofortified-beef-a-comparison-of-cholecalciferol-with-synthetic-versus-uvb-mushroom-derived-ergosterol-as-feed-source
#8
Sarah K Duffy, John V O'Doherty, Gaurav Rajauria, Louise C Clarke, Aoife Hayes, Kirsten G Dowling, Michael N O'Grady, Joseph P Kerry, Jette Jakobsen, Kevin D Cashman, Alan K Kelly
This study investigates dietary fortification of heifer feeds with cholecalciferol and ergocalciferol sources and effects on beef total vitamin D activity, vitamer, respective 25-hydroxymetabolite contents, and meat quality. Thirty heifers were allocated to one of three dietary treatments [(1) basal diet + 4000 IU of vitamin D3 (Vit D3 ); (2) basal diet + 4000 IU of vitamin D2 (Vit D2 ); and (3) basal diet + 4000 IU of vitamin D2 -enriched mushrooms (Mushroom D2 )] for a 30 day pre-slaughter period...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29574135/cryopreservation-and-in-vitro-culture-of-white-tailed-deer-ovarian-tissue
#9
G D A Gastal, F L N Aguiar, A P R Rodrigues, J M Scimeca, G A Apgar, W J Banz, J M Feugang, E L Gastal
The aims of this study were to evaluate (1) the survivability of white-tailed deer ovarian tissue after cryopreservation by slow-freezing (SF) and vitrification (VIT) techniques and in vitro culture (IVC) for up to 7 days, and (2) the effects of cryopreservation techniques on protein expression of proliferative and apoptotic markers of ovarian tissue pre- and post-in vitro culture. Ovaries (n = 14) of seven white-tailed deer fawns (<1.5 years old) were used. Ovarian cortexes were cut into fragments (2 × 2 × 0...
March 8, 2018: Theriogenology
https://www.readbyqxmd.com/read/29555416/phosphorus-kinetics-in-lambs-experimentally-infected-with-trichostrongylus-colubriformis-with-the-use-of-32-p
#10
Tairon Pannunzio Dias E Silva, Carolina Rodriguez Jimenez, Egon Ion Ieda, Adibe Luiz Abdalla, Helder Louvandini
This study was conducted to evaluate the metabolism and phosphorus (P) kinetics in lambs experimentally infected with Trichostrongylus colubriformis using the isotope dilution technique and modelling. Fifteen male lambs (21.1 ± 1.50 kg) of the Santa Inês hair breed of approximately six months old, distributed in the treatments infected (I, n = 8) and control (C, n = 7) were used. The infected lambs received serial infections with 5000 T. colubriformis larvae, three times per week, for 3 weeks (45 000 T...
May 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29538679/advanced-glycation-end-products-alter-steroidogenic-gene-expression-by-granulosa-cells-an-effect-partially-reversible-by-vitamin-d
#11
Z Merhi, E Buyuk, M J Cipolla
STUDY QUESTION: Does vitamin D attenuate the adverse effects of advanced glycation end products (AGEs) on steroidogenesis by human granulosa cells (GCs)? SUMMARY ANSWER: AGEs alter the expression of genes important in steroidogenesis while 1,25-dihydroxyvitamin D3 (vit D3) in vitro attenuates some of the actions of AGEs on steroidogenic gene expression, possibly by downregulating the expression of the pro-inflammatory cell membrane receptor for AGEs (RAGE). WHAT IS KNOWN ALREADY: Vitamin D attenuates the pro-inflammatory effects of AGEs in non-ovarian tissues...
June 1, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29423219/the-effect-of-protein-supplementation-on-body-muscle-mass-and-fat-mass-in-post-bariatric-surgery-a-randomized-controlled-trial-rct-study-protocol
#12
Sahar D Al-Shamari, Mohamed Aly ElSherif, Wahiba Hamid, Fahad Hanna
Background: Severe weight loss through means of bariatric surgery has been associated with loss of muscle mass due to lack of absorption of protein. The aim of this RCT is to investigate the effectiveness of protein supplementation in reducing the risk of developing protein malnutrition and muscle wasting in post-bariatric surgery patients in Qatar. Methods and analysis: The study was based at the Department of bariatric and metabolic surgery, Doha metropolitan and regional areas...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29420305/effect-of-slco1b1-gene-polymorphisms-and-vitamin-d-on-statin-induced-myopathy
#13
Baraa Alghalyini, Said El Shamieh, Ali Salami, Sophie Visvikis Siest, Hana M Fakhoury, Rajaa Fakhoury
Background Statin therapy used to lower cholesterol levels results in a substantial reduction in cardiovascular complications. Previous observations in different ethnic populations showed that rs2306283A>G, p.Asn130Asp and rs4149056T>C, p.Val174Ala in solute carrier organic anion transporter 1B1 (SLCO1B1) gene encoding the organic transporter protein may be responsible for statin uptake, thus explaining the majority of statin-associated symptoms. In addition to the genetic component, vitamin D (vit D) deficiency is common in Saudi Arabia and worldwide and may cause muscle dysfunction and ache...
March 28, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29368145/combination-of-oxaliplatin-and-vit-e-tpgs-in-lipid-nanosystem-for-enhanced-therapeutic-efficacy-in-colon-cancers
#14
Yanlei Wang, Xiang Zhang, Wenqiang Zhang, Hao Dong, Wenjie Zhang, Jiajia Mao, Yong Dai
PURPOSE: The main aim of present study was to prepare the oxaliplatin (OXL)-loaded D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)-based lipid nanoparticles to enhance the anticancer effect in colon cancer cells. METHODS: The nanoparticles were nanosized and spherical shaped and exhibited controlled release kinetics. Flow cytometer and confocal laser scanning microscopy (CLSM) showed a remarkable uptake of nanoparticles in cancer cells in a time-dependent manner...
January 8, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29336863/age-associated-expression-of-vitamin-d-receptor-and-vitamin-d-metabolizing-enzymes-in-the-male-reproductive-tract-and-sperm-of-hu-sheep
#15
Xiaolei Yao, M A Ei-Samahy, Hua Yang, Xu Feng, Fengzhe Li, Fanxing Meng, Haitao Nie, Feng Wang
The cellular response to 1,25-dihydroxyvitamin D3 (Vit D3 ; biologically active form of Vitamin D) is complex and depends not only on Vitamin D receptor (VDR) expression but also on cellular uptake of circulating Vit D3 and the presence and activity of Vitamin D-metabolizing enzyme. This study evaluated the expression of VDR and Vitamin D-metabolizing enzymes in the ram reproductive tract at different developmental stages and in spermatozoa. Nearly all cell types in the testes and epithelial cells of the caput, corpus, and cauda expressed VDR, CYP27B1, and CYP24A1 proteins...
March 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29221946/-facing-a-dilemma-in-elderly-complex-and-vulnerable-patients-to-stop-or-not-to-stop-prevention
#16
Laura Llobet Vila, Josep Maria Manresa Domínguez, José Manuel Carmona Segado, Alícia Franzi Sisó, Rosa Vallès Balasch, Isabel Martínez Díaz
OBJECTIVES: 1-To know the preventive prescription (statin, antiplatelet drugs, bisphosphonates, calcium and vitamin D and Vit B12) of elderly patients previously identified as a CCD (with a complex chronic disease) and ACD (with advanced chronic disease and lifetime expectancy of less than 12 months) who died during 2015. 2-To assess the correct indication of Proton Pump Inhibitors (PPI) to determine potentially avoidable medication. DESIGN: Retrospective observational study...
December 5, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29165650/evaluation-of-1-25-dihydroxyvitamin-d3-pathway-in-patients-with-chronic-urticaria
#17
R Nasiri-Kalmarzi, M Abdi, J Hosseini, E Babaei, A Mokarizadeh, Z Vahabzadeh
Background: Previous studies showed the role of vitamin D (Vit D) on the progression of chronic urticaria. To the best of our knowledge, there are no other results regarding the contribution of single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes in chronic urticaria (CU). Aim: In the present study, we investigated the Vit pathway and the association between VDR and VDBP gene polymorphisms and CU risk in Iranian population...
March 1, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29040674/evaluation-of-apoptotic-and-autophagic-related-protein-expressions-before-and-after-ivm-of-fresh-slow-frozen-and-vitrified-pre-pubertal-mouse-testicular-tissue
#18
L Dumont, F Chalmel, A Oblette, B Berby, A Rives, V Duchesne, C Rondanino, N Rives
STUDY QUESTION: Do freezing and in vitro culture procedures enhance the expression of proteins involved in apoptotic or autophagic pathways in murine pre-pubertal testicular tissue? SUMMARY ANSWER: IVM strongly modified apoptosis- and autophagy-related relative protein levels in mice testicular tissue whereas the impact of cryopreservation procedures was minimal at the end of the culture. WHAT IS KNOWN ALREADY: In vitro spermatogenesis remains a challenging technical issue as it imposes to find a very close balance between survival and death of germ cell natural precursors (i...
November 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28949229/first-measurement-of-transverse-spin-dependent-azimuthal-asymmetries-in-the-drell-yan-process
#19
M Aghasyan, R Akhunzyanov, G D Alexeev, M G Alexeev, A Amoroso, V Andrieux, N V Anfimov, V Anosov, A Antoshkin, K Augsten, W Augustyniak, A Austregesilo, C D R Azevedo, B Badełek, F Balestra, M Ball, J Barth, R Beck, Y Bedfer, J Bernhard, K Bicker, E R Bielert, R Birsa, M Bodlak, P Bordalo, F Bradamante, A Bressan, M Büchele, W-C Chang, C Chatterjee, M Chiosso, I Choi, S-U Chung, A Cicuttin, M L Crespo, S Dalla Torre, S S Dasgupta, S Dasgupta, O Yu Denisov, L Dhara, S V Donskov, N Doshita, Ch Dreisbach, W Dünnweber, M Dziewiecki, A Efremov, P D Eversheim, M Faessler, A Ferrero, M Finger, M Finger, H Fischer, C Franco, N du Fresne von Hohenesche, J M Friedrich, V Frolov, E Fuchey, F Gautheron, O P Gavrichtchouk, S Gerassimov, J Giarra, F Giordano, I Gnesi, M Gorzellik, A Grasso, M Grosse Perdekamp, B Grube, T Grussenmeyer, A Guskov, D Hahne, G Hamar, D von Harrach, F H Heinsius, R Heitz, F Herrmann, N Horikawa, N d'Hose, C-Y Hsieh, S Huber, S Ishimoto, A Ivanov, Yu Ivanshin, T Iwata, V Jary, R Joosten, P Jörg, E Kabuß, A Kerbizi, B Ketzer, G V Khaustov, Yu A Khokhlov, Yu Kisselev, F Klein, J H Koivuniemi, V N Kolosov, K Kondo, K Königsmann, I Konorov, V F Konstantinov, A M Kotzinian, O M Kouznetsov, Z Kral, M Krämer, P Kremser, F Krinner, Z V Kroumchtein, Y Kulinich, F Kunne, K Kurek, R P Kurjata, A Kveton, A A Lednev, M Levillain, S Levorato, Y-S Lian, J Lichtenstadt, R Longo, A Maggiora, A Magnon, N Makins, N Makke, G K Mallot, B Marianski, A Martin, J Marzec, J Matoušek, H Matsuda, T Matsuda, G V Meshcheryakov, M Meyer, W Meyer, Yu V Mikhailov, M Mikhasenko, E Mitrofanov, N Mitrofanov, Y Miyachi, A Nagaytsev, F Nerling, D Neyret, J Nový, W-D Nowak, G Nukazuka, A S Nunes, A G Olshevsky, I Orlov, M Ostrick, D Panzieri, B Parsamyan, S Paul, J-C Peng, F Pereira, M Pešek, D V Peshekhonov, N Pierre, S Platchkov, J Pochodzalla, V A Polyakov, J Pretz, M Quaresma, C Quintans, S Ramos, C Regali, G Reicherz, C Riedl, N S Rogacheva, M Roskot, D I Ryabchikov, A Rybnikov, A Rychter, R Salac, V D Samoylenko, A Sandacz, C Santos, S Sarkar, I A Savin, T Sawada, G Sbrizzai, P Schiavon, K Schmidt, H Schmieden, K Schönning, E Seder, A Selyunin, O Yu Shevchenko, L Silva, L Sinha, S Sirtl, M Slunecka, J Smolik, A Srnka, D Steffen, M Stolarski, O Subrt, M Sulc, H Suzuki, A Szabelski, T Szameitat, P Sznajder, S Takewaka, M Tasevsky, S Tessaro, G Terça, F Tessarotto, A Thiel, J Tomsa, F Tosello, V Tskhay, S Uhl, A Vauth, J Veloso, M Virius, M Vit, J Vondra, S Wallner, T Weisrock, M Wilfert, J Ter Wolbeek, K Zaremba, P Zavada, M Zavertyaev, E Zemlyanichkina, N Zhuravlev, M Ziembicki
The first measurement of transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan (DY) process is reported. We use the CERN SPS 190  GeV/c π^{-} beam and a transversely polarized ammonia target. Three azimuthal asymmetries giving access to different transverse-momentum-dependent (TMD) parton distribution functions (PDFs) are extracted using dimuon events with invariant mass between 4.3  GeV/c^{2} and 8.5  GeV/c^{2}. Within the experimental uncertainties, the observed sign of the Sivers asymmetry is found to be consistent with the fundamental prediction of quantum chromodynamics (QCD) that the Sivers TMD PDFs extracted from DY have a sign opposite to the one extracted from semi-inclusive deep-inelastic scattering (SIDIS) data...
September 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28942016/positron-emission-tomography-based-assessment-of-metabolic-tumor-volume-predicts-survival-after-autologous-hematopoietic-cell-transplantation-for-hodgkin-lymphoma
#20
Vít Procházka, Rakhee S Gawande, Zuzan Cayci, Jerry W Froelich, Qing Cao, Chris Wilke, Kathryn Dusenbery, Daniel J Weisdorf, Veronika Bachanova
Autologous hematopoietic cell transplantation (AHCT) is curative for 60% of patients with relapsed or refractory Hodgkin lymphoma (R/R HL). A more precise assessment of the depth of remission before AHCT may help to identify patients likely to benefit from AHCT. We aimed to determine whether positron emission tomography (PET)-based quantitative parameters of total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), and maximal standardized uptake volume (SUVmax ) measured before AHCT predict progression-free survival (PFS) after transplant...
January 2018: Biology of Blood and Marrow Transplantation
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