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https://www.readbyqxmd.com/read/29040674/evaluation-of-apoptotic-and-autophagic-related-protein-expressions-before-and-after-ivm-of-fresh-slow-frozen-and-vitrified-pre-pubertal-mouse-testicular-tissue
#1
L Dumont, F Chalmel, A Oblette, B Berby, A Rives, V Duchesne, C Rondanino, N Rives
STUDY QUESTION: Do freezing and in vitro culture procedures enhance the expression of proteins involved in apoptotic or autophagic pathways in murine pre-pubertal testicular tissue? SUMMARY ANSWER: IVM strongly modified apoptosis- and autophagy-related relative protein levels in mice testicular tissue whereas the impact of cryopreservation procedures was minimal at the end of the culture. WHAT IS KNOWN ALREADY: In vitro spermatogenesis remains a challenging technical issue as it imposes to find a very close balance between survival and death of germ cell natural precursors (i...
November 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28949229/first-measurement-of-transverse-spin-dependent-azimuthal-asymmetries-in-the-drell-yan-process
#2
M Aghasyan, R Akhunzyanov, G D Alexeev, M G Alexeev, A Amoroso, V Andrieux, N V Anfimov, V Anosov, A Antoshkin, K Augsten, W Augustyniak, A Austregesilo, C D R Azevedo, B Badełek, F Balestra, M Ball, J Barth, R Beck, Y Bedfer, J Bernhard, K Bicker, E R Bielert, R Birsa, M Bodlak, P Bordalo, F Bradamante, A Bressan, M Büchele, W-C Chang, C Chatterjee, M Chiosso, I Choi, S-U Chung, A Cicuttin, M L Crespo, S Dalla Torre, S S Dasgupta, S Dasgupta, O Yu Denisov, L Dhara, S V Donskov, N Doshita, Ch Dreisbach, W Dünnweber, M Dziewiecki, A Efremov, P D Eversheim, M Faessler, A Ferrero, M Finger, M Finger, H Fischer, C Franco, N du Fresne von Hohenesche, J M Friedrich, V Frolov, E Fuchey, F Gautheron, O P Gavrichtchouk, S Gerassimov, J Giarra, F Giordano, I Gnesi, M Gorzellik, A Grasso, M Grosse Perdekamp, B Grube, T Grussenmeyer, A Guskov, D Hahne, G Hamar, D von Harrach, F H Heinsius, R Heitz, F Herrmann, N Horikawa, N d'Hose, C-Y Hsieh, S Huber, S Ishimoto, A Ivanov, Yu Ivanshin, T Iwata, V Jary, R Joosten, P Jörg, E Kabuß, A Kerbizi, B Ketzer, G V Khaustov, Yu A Khokhlov, Yu Kisselev, F Klein, J H Koivuniemi, V N Kolosov, K Kondo, K Königsmann, I Konorov, V F Konstantinov, A M Kotzinian, O M Kouznetsov, Z Kral, M Krämer, P Kremser, F Krinner, Z V Kroumchtein, Y Kulinich, F Kunne, K Kurek, R P Kurjata, A Kveton, A A Lednev, M Levillain, S Levorato, Y-S Lian, J Lichtenstadt, R Longo, A Maggiora, A Magnon, N Makins, N Makke, G K Mallot, B Marianski, A Martin, J Marzec, J Matoušek, H Matsuda, T Matsuda, G V Meshcheryakov, M Meyer, W Meyer, Yu V Mikhailov, M Mikhasenko, E Mitrofanov, N Mitrofanov, Y Miyachi, A Nagaytsev, F Nerling, D Neyret, J Nový, W-D Nowak, G Nukazuka, A S Nunes, A G Olshevsky, I Orlov, M Ostrick, D Panzieri, B Parsamyan, S Paul, J-C Peng, F Pereira, M Pešek, D V Peshekhonov, N Pierre, S Platchkov, J Pochodzalla, V A Polyakov, J Pretz, M Quaresma, C Quintans, S Ramos, C Regali, G Reicherz, C Riedl, N S Rogacheva, M Roskot, D I Ryabchikov, A Rybnikov, A Rychter, R Salac, V D Samoylenko, A Sandacz, C Santos, S Sarkar, I A Savin, T Sawada, G Sbrizzai, P Schiavon, K Schmidt, H Schmieden, K Schönning, E Seder, A Selyunin, O Yu Shevchenko, L Silva, L Sinha, S Sirtl, M Slunecka, J Smolik, A Srnka, D Steffen, M Stolarski, O Subrt, M Sulc, H Suzuki, A Szabelski, T Szameitat, P Sznajder, S Takewaka, M Tasevsky, S Tessaro, G Terça, F Tessarotto, A Thiel, J Tomsa, F Tosello, V Tskhay, S Uhl, A Vauth, J Veloso, M Virius, M Vit, J Vondra, S Wallner, T Weisrock, M Wilfert, J Ter Wolbeek, K Zaremba, P Zavada, M Zavertyaev, E Zemlyanichkina, N Zhuravlev, M Ziembicki
The first measurement of transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan (DY) process is reported. We use the CERN SPS 190  GeV/c π^{-} beam and a transversely polarized ammonia target. Three azimuthal asymmetries giving access to different transverse-momentum-dependent (TMD) parton distribution functions (PDFs) are extracted using dimuon events with invariant mass between 4.3  GeV/c^{2} and 8.5  GeV/c^{2}. Within the experimental uncertainties, the observed sign of the Sivers asymmetry is found to be consistent with the fundamental prediction of quantum chromodynamics (QCD) that the Sivers TMD PDFs extracted from DY have a sign opposite to the one extracted from semi-inclusive deep-inelastic scattering (SIDIS) data...
September 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28942016/positron-emission-tomography-based-assessment-of-metabolic-tumor-volume-predicts-survival-after-autologous-hematopoietic-cell-transplantation-for-hodgkin-lymphoma
#3
Vít Procházka, Rakhee S Gawande, Zuzan Cayci, Jerry W Froelich, Qing Cao, Chris Wilke, Kathryn Dusenbery, Daniel J Weisdorf, Veronika Bachanova
Autologous hematopoietic cell transplantation (AHCT) is curative for 60% of patients with relapsed or refractory Hodgkin lymphoma (R/R HL). A more precise assessment of the depth of remission before AHCT may help to identify patients likely to benefit from AHCT. We aimed to determine whether positron emission tomography (PET)-based quantitative parameters of total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), and maximal standardized uptake volume (SUVmax) measured before AHCT predict progression-free survival (PFS) after transplant...
September 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28879647/evaluation-of-vitamin-d-concentration-in-a-population-of-young-healthy-women-effects-of-vitamin-d-supplementation
#4
Ewa Sewerynek, Karol Cieślak, Małgorzata Janik, Ewelina Gowin, Michał Stuss
The goal of the study was an evaluation of serum vitamin D concentrations in healthy young women. MATERIAL AND METHODS: 106 healthy women, aged 20-30 years, were included in the study. Monthly evaluation - for three months - of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women with baseline values of vit. D < 20 ng/ml (Group 1) plus the effects of 800 IU/d dose in women with the baseline value of D > 20 ng/ml (Group2). Additionally, calcium and PTH concentrations were assessed at the study onset and after a 3-month supplementation...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28698476/acute-supplementation-with-high-dose-vitamin-d3-increases-serum-anti-m%C3%A3-llerian-hormone-in-young-women
#5
Nicola A Dennis, Lisa A Houghton, Michael W Pankhurst, Michelle J Harper, Ian S McLennan
Anti-Müllerian hormone (AMH) is a paracrine regulator of ovarian follicles. Vitamin D (Vit D) regulates AMH production in vitro, but its role as a regulator of ovarian AMH production is contentious. If Vit D influences ovarian AMH production, then an acute rise in Vit D level should lead to an acute rise in circulating AMH levels. This hypothesis was tested with a randomized double-blind design, with 18-25-year-old women recruited from the community. The study was conducted in early spring, when the marker of Vit D level (25-hydroxyvitamin D, 25(OH)D) tends to be at its nadir...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28687854/neuroprotective-effects-of-vitamin-d-alone-or-in-combination-with-lamotrigine-against-lithium-pilocarpine-model-of-status-epilepticus-in-rats
#6
Amal M Mahfoz, Ali F Abdel-Wahab, Mohamed A Afify, Naiyer Shahzad, Ibrahim A A Ibrahim, Naser A ElSawy, Ghazi A Bamagous, Saeed S Al Ghamdi
Status epilepticus (SE) is considered one of the major serious forms of epilepsy with high mortality rate. Since the currently available antiepileptic drugs have low efficacy and high adverse effects, new more efficient and safe therapies are critically needed. There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Recent studies have shown significant prophylactic and therapeutic potential of vitamin D (vit-D) use in many neurological disorders...
July 7, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28658959/vitamin-c-attenuates-methotrexate-induced-oxidative-stress-in-kidney-and-liver-of-rats
#7
M Savran, E Cicek, D K Doguc, H Asci, S Yesilot, I A Candan, B Dagdeviren, F N Cankara, M Oncu, A C Uğuz, M K Ozer
Like several other anticancer drugs, methotrexate (MTX) causes side effects, such as neuropathic pain, hepatotoxicity, and nephrotoxicity. Abnormal production of reactive oxygen species has been suspected in the pathophysiology of MTX-induced hepatorenal toxicity. Therefore, the aim of this study was to investigate the probable protective role of vitamin C (Vit C) on oxidative stress induced by MTX in the liver and kidney tissues of rats. A total of 32 rats were randomly and equally divided into four groups...
June 29, 2017: Physiology International
https://www.readbyqxmd.com/read/28645722/circulating-bone-related-markers-and-ykl-40-versus-her2-and-topo2a-in-bone-metastatic-and-nonmetastatic-breast-cancer-diagnostic-implications
#8
Olfat Gamil Shaker, Hebatullah Samy Helmy
BACKGROUND: The bone represents one of the most common sites of metastases in breast cancer. The aim of the current study was to evaluate the diagnostic potential of several circulating markers to detect metastasis to bones in patients with breast cancer. PATIENTS AND METHODS: Receptor activator of Nuclear Factor-kappa β (NF-Kβ) ligand (RANKL), osteoprotegrin (OPG), vitamin D (VIT D), Chitinase-3-like protein 1; also known as YKL-40, topoisomerase IIα (TOPO2a), and human epidermal growth factor receptor 2 (HER2) were measured in blood samples obtained from 122 patients with breast cancer and 25 healthy controls...
June 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28608241/vit-d-deficiency-is-a-possible-risk-factor-in-ars
#9
Mustafa Suphi Elbistanlı, Hasan Emre Koçak, Selçuk Güneş, Harun Acıpayam, Baver Maşallah Şimşek, Sinan Canpolat, Fatma Tülin Kayhan
Vitamin D deficiency is effective in the development of acute rhinosinusitis and prolongation of inflammation by increasing inflammation in the sinonasal epithelium. Vitamin D deficiency is important in the development of bone barriers that prevent the complication of acute rhinosinusitis. Although Vitamin D levels may be a variable risk factor for various respiratory tract disorders, there are limited data on the role in sinonasal infections. Our aim was to investigate the association of 25-hydroxy-vitamin D (25OHD) levels with acute rhinosinusitis (ARS) and preseptal cellulitis complications...
June 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28559717/serum-vitamin-d-levels-in-indian-patients-with-retinal-venous-occlusions
#10
Avadhesh Oli, D Joshi
PURPOSE: To estimate serum vitamin D (25 OH D) level in patients of retinal vein occlusion (RVO) and compare it with age-matched controls. METHODS AND MATERIAL: Forty patients above 18 years of age with retinal vein occlusion and forty age-matched controls underwent serum vitamin D (Vit D) level estimation using a standard protocol. Student's t test was used to analyse differences between the mean of two groups. RESULTS: The mean age in RVO and control group was 60...
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28475159/acute-vitamin-d%C3%A2-supplementation-in-severe-obesity-evaluation-of-multimeric-adiponectin
#11
Stefania Mai, Gillian E Walker, Roberta Vietti, Stefania Cattaldo, Chiara Mele, Lorenzo Priano, Alessandro Mauro, Gianni Bona, Gianluca Aimaretti, Massimo Scacchi, Paolo Marzullo
Obesity predisposes to vitamin D deficiency (VDD) and glucose abnormalities. It is currently debated if vitamin D administration may improve glucose homeostasis by interacting with modulators of insulin sensitivity, such as adiponectin and its oligomers. In a 4-week inpatient study on a metabolic rehabilitation program, consisting of individualized caloric restriction and aerobic physical exercise in obese subjects with VDD, we assessed the acute effects of 600,000 IU cholecalciferol given per os VD group, 12 subjects; body mass index (BMI) 42...
May 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28418990/bone-density-microarchitecture-and-tissue-quality-after-long-term-treatment-with-tenofovir-emtricitabine-or-abacavir-lamivudine
#12
Robert Güerri-Fernández, Daniel Molina-Morant, Judit Villar-García, Sabina Herrera, Alicia González-Mena, Ana Guelar, Marta Trenchs-Rodríguez, Adolfo Díez-Pérez, Hernando Knobel
OBJECTIVES: HIV infection has been associated with reduced bone mineral density (BMD). Antiretroviral therapy (ART) has a deleterious effect on BMD, but its effect on bone fragility is not clear. The objective of this study is to analyze the BMD, microarchitecture, and tissue quality of bone in patients receiving long-term tenofovir- or abacavir-based ART. DESIGN: We conducted a cross-sectional study in patients with HIV undergoing tenofovir or abacavir ART for more than 5 years...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28187310/proteomic-analysis-of-liver-tissue-from-rainbow-trout-oncorhynchus-mykiss-under-high-rearing-density-after-administration-of-dietary-vitamin-e-and-selenium-nanoparticles
#13
Mahdi Naderi, Saeed Keyvanshokooh, Amir Parviz Salati, Alireza Ghaedi
The aim of the present study was to investigate the effects of dietary vitamin E (vit E) and selenium nanoparticles (nanoSe) on liver proteome profile of rainbow trout under high density condition. To correlate the proteome modifications with physiological aspects, growth, serum metabolites (cortisol, glucose, lactate, ALT, AST, and ALP), and liver antioxidant-related parameters (SOD, GPx, CAT, and MDA) were also examined. A total of 1275 fish (average weight of 42.6±2.3g) were stocked into 12 tanks at a density of 80kgm(-3)...
June 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28129773/investigation-of-the-vitamin-d-nutritional-status-in-women-with-gestational-diabetes-mellitus-in-beijing
#14
Yanping Liu, Qiaer Jin, Yuanyuan Bao, Shanshan Li, Jing Wang, Ling Qiu
BACKGROUND: Vitamin D deficiency is a common issue, which has relation with GDM, during the pregnant period. To study the Vitamin D nutritional status of pregnant women with gestational diabetes mellitus (GDM) in the middle and late pregnancy and analyze the different sources of Vitamin D intake. METHODS: A total of ninety-eight pregnant women with GDM were enrolled voluntarily in this study. The patients were divided into two groups, Vitamin D supplement intake and control group...
January 28, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28112206/serum-vitamin-d-intact-parathyroid-hormone-and-fetuin-a-concentrations-were-associated-with-geriatric-sarcopenia-and-cardiac-hypertrophy
#15
Wei-Ting Chang, Chih-Hsing Wu, Ling-Wei Hsu, Po-Wei Chen, Jia-Rong Yu, Chin-Sung Chang, Wei-Chuan Tsai, Ping-Yen Liu
With aging, intact parathyroid hormone (iPTH) increases. It plays a crucial role in left ventricular hypertrophy (LVH). Also, 25-hydroxy vitamin D (Vit-D) and iPTH have been observed to be determinants of muscle wasting known as sarcopenia. Fetuin A (FetA), a systemic calcification inhibitor, involves in the development of diastolic heart failure. Hence, we hypothesized that the interplay among FetA, Vit-D and iPTH may contribute to sarcopenic LVH among the elders. We analyzed a database from the Tianliao Old People study with 541 elders (≥65 years) in a Taiwan's suburban community...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27999642/benefits-from-the-correction-of-vitamin-d-deficiency-in-patients-with-pulmonary-hypertension
#16
Ahmad Mirdamadi, Pouya Moshkdar
BACKGROUND: Vitamin D (Vit D) is linked to various conditions including musculoskeletal, metabolic and cardiopulmonary diseases. However, it is not clear whether correction of vit D deficiency exerts any beneficial effect in patients with pulmonary hypertension. METHODS: This study was a prospective uncontrolled longitudinal study. Patients with pulmonary hypertension and vit D deficiency were enrolled into this study. All patients in addition to standard treatment for pulmonary hypertension received cholecalciferol at a dose of 50,000 IU weekly plus calcicare (at a dose of 200 mg magnesium + 8 mg zinc + 400 IU vit D) daily for 3 months...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27996943/insect-venom-immunotherapy-analysis-of-the-safety-and-tolerance-of-3-buildup-protocols-frequently-used-in-spain
#17
MULTICENTER STUDY
D Gutiérrez Fernández, A Moreno-Ancillo, S Fernández Meléndez, C Domínguez-Noche, P Gálvez Ruiz, T Alfaya Arias, F Carballada González, A Alonso Llamazares, L Marques Amat, A Vega Castro, D Antolín Amérigo, S Cruz Granados, B Ruiz León, L Sánchez Morillas, J Fernández Sánchez, V Soriano Gomis, J Borja Segade, G Dalmau Duch, R Guspi Bori, A Miranda Páez
INTRODUCTION: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk, as both local and systemic adverse reactions may occur, especially in the initial phases. We compared the tolerance to 3 VIT buildup protocols and analyzed risk factors associated with adverse reactions during this phase. MATERIALS AND METHODS: We enrolled 165 patients divided into 3 groups based on the buildup protocol used (3, 4, and 9 weeks). The severity of systemic reactions was evaluated according to the World Allergy Organization model...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27941176/protective-effects-of-boron-and-vitamin-e-on-ethylene-glycol-induced-renal-crystal-calcium-deposition-in-rat
#18
H Bahadoran, M R Naghii, M Mofid, M H Asadi, K Ahmadi, A Sarveazad
OBJECTIVES: Kidney stone disease is a common form of renal disease. Antioxidants, such as vitamin E (Vit E) and boron, are substances that reduce the damage caused by oxidation. METHODS: Adult male rats were divided into 5 groups (n=6). In group 1, rats received standard food and water for 28 days (control group); in group 2, standard rodent food and water with 0.75% ethylene glycol/d (dissolved in drinking water) (EG Group); in group 3, similar to group 2, with 3 mg of boron/d (dissolved in water) (EG+B Group); in group 4, similar to group 2, with 200 IU of vitamin E injected intraperitoneally on the first day and the 14th day, (EG+Vit E Group); in group 5, mix of groups 3 and 4, respectively (EG+B+Vit E Group)...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#19
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette LaMarca
Autoantibodies to the ANG II type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined whether the decrease in AT1-AA was the mechanism whereby vitamin D lowered MAP or if it were through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1, and soluble FMS-like tyrosine kinase-1 are increased with AT1-AA-induced hypertension and are considered markers of PE in pregnant women...
January 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27863277/vitamin-d-supplementation-affects-the-igf-system-in-men-after-acute-exercise
#20
Rachel L Darr, Kathleen J Savage, Mark Baker, Gregory E Wilding, Amy Raswalsky, Todd Rideout, Richard W Browne, Peter J Horvath
OBJECTIVE: Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system. DESIGN: D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit...
October 2016: Growth Hormone & IGF Research
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