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https://www.readbyqxmd.com/read/29684617/association-of-diabetes-mellitus-with-prostate-cancer-grade-and-prostate-specific-antigen-in-chinese-biopsy-population
#1
Ming Chen, Yili Luo, Shaoling Yang, Lu Xu, Nan Li, Hong Li, Shen Qu
AIMS: To investigate the association of diabetes mellitus with prostate cancer (PCa) grade and prostate-specific antigen (PSA) in Chinese biopsy population. METHODS: We retrospectively evaluated data from 2032 patients who underwent prostate biopsies from 2010-2016 at our hospital. All diabetes cases were divided into sub-groups according to HbA1c (< 6.5%, 6.5%-7.49% and ≥ 7.5%) and diabetes duration (0-5 years, 6-10 years and > 10 years). RESULTS: Among 2032 men, 467 (23...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29683909/acog-committee-opinion-no-734-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#2
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683904/acog-committee-opinion-no-734-summary-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#3
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683402/identification-and-evaluation-of-bioactive-natural-products-as-potential-inhibitors-of-human-microtubule-affinity-regulating-kinase-4-mark4
#4
Taj Mohammad, Faez Iqbal Khan, Kevin A Lobb, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassan
Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex diseases including cancer, diabetes and neurodegenerative disorders. Inhibition of MARK4 activity is an appealing therapeutic option to treat such diseases. Here, we have performed structure-based virtual high-throughput screening of 100,000 naturally occurring compounds from ZINC database against MARK4 to find its potential inhibitors. The resulted hits were selected based on the binding affinities, docking scores and selectivity...
April 23, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29682714/-factors-associated-with-anastomotic-leakage-after-anterior-resection-in-rectal-cancer
#5
Kai Deng, Jianli Zhang, Xiuli Jiang, Shuai Feng
OBJECTIVE: To investigate the factors associated with the anastomotic leakage after anterior resection in rectal cancer. METHODS: From January 2014 to January 2017 471 patients underwent Dixon procedure for rectal cancer in The Affiliated Hospital of Qingdao University. The data of those patients was collected and reviewed retrospectively. Inclusion criteria included: 1) rectal cancer confirmed by preoperative electron colonoscopy; 2) the standard of total mesorectal excision followed by the surgeon during the surgery; and 3) elective surgery...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682713/-risk-factors-of-anastomotic-leakage-after-anterior-resection-for-rectal-cancer-and-the-diagnostic-value-of-computed-tomography-signs-in-anastomotic-leakage
#6
Junling Zhang, Xiaochao Guo, Jixin Zhang, Jing Liu, Tao Wu, Pengyuan Wang, Guowei Chen, Yong Jiang, Yingchao Wu, Xin Wang
OBJECTIVE: To investigate the risk factors and computed tomography (CT) diagnostic accuracy of anastomotic leakage after resection of rectal cancer (Dixon). METHODS: This retrospective study was conducted in Peking University First Hospital from January 2013 to June 2015. A cohort of 452 patients with rectal cancer was enrolled in the study. All the patients underwent anterior resection. The relationship between clinical-pathological data (including sex, age, body mass index (BMI), presence of diabetes, hypohemoglobin (Hb<90 g/L), hypoalbuminemia (Alb<35 g/L), the distance from the lower edge of the tumors to the anus, tumor diameter, tumor differentiation, tumor TNM stage, neoadjuvant therapy status, ligation of the left colonic artery(LCA), preventive colostomy, and anastomotic leakage was analyzed retrospectively...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682706/-risk-factors-of-anastomotic-leakage-in-the-procedures-of-trans-abdominal-and-transanal-total-mesorectal-excision-for-rectal-cancer
#7
Hongwei Yao, Zhongtao Zhang
Anastomotic leakage is one of the most serious complications following traditional trans-abdominal total mesorectal excision of rectal cancer. Anastomotic leakage not only affects the postoperative recovery of patients, but also affects their long-term survival. Transanal total mesorectal excision(taTME) is a new surgical procedure developed in recent years. Its anastomosis is different from traditional trans-abdominal total mesorectal excision surgery. The risk of anastomotic leakage and related risk factors are also different...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682326/survival-and-glycemic-control-outcomes-among-patients-with-coexisting-pancreatic-cancer-and-diabetes-mellitus
#8
Nina J Karlin, Shailja B Amin, Heidi E Kosiorek, Matthew R Buras, Patricia M Verona, Curtiss B Cook
Aim: We aimed to determine the effect of diabetes mellitus (DM) on survival in pancreatic cancer and effects of pancreatic cancer on glycemic control in DM. Materials & methods: Patients with pancreatic cancer from 2007 to 2015, with and without DM, were matched 1:1. We compared characteristics between the groups and assessed 2-year survival with Kaplan-Meier analysis. Results: In patients with DM, hemoglobin A1c decreased significantly over time (p = 0...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29681621/circulating-cell-free-nucleic-acids-characteristics-and-applications
#9
REVIEW
Ondrej Pös, Orsolya Biró, Tomas Szemes, Bálint Nagy
Liquid biopsy is becoming a very popular sample obtaining procedure, replacing the invasive sampling methods for the diagnostic protocols. The advantages of this method include the possibility to isolate cell-free nucleic acids (cfNAs) for diagnostic or screening purposes. A comprehensive review combining all current and perspective applications of cell-free nucleic acids is missing. Published articles are dealing with one type of cfNAs, or discuss them from the perspective of single disorder. We collected here all known types of cfNAs which are known to be present in biological fluids and could be involved in further studies to find out the exact biological role of them in normal physiological and pathological conditions...
April 23, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29679627/diabetes-and-cancer-pathophysiological-fundamentals-of-a-dangerous-affair
#10
REVIEW
Angelo Cignarelli, Valentina Annamaria Genchi, Irene Caruso, Annalisa Natalicchio, Sebastio Perrini, Luigi Laviola, Francesco Giorgino
Diabetes and cancer are worldwide chronic diseases with a major impact on the quality and expectancy of life. Metabolic abnormalities observed during the onset and progression of diabetes may have a critical role on the initiation and progression of carcinogenesis. To date, there are no conclusive data on the mechanisms underlying the relationship between diabetes and any type of human cancer. However, recent evidence suggests that both hyperglycemia and hyperinsulinemia in diabetes could elicit cell damage responses, such as glucotoxicity, lipotoxicity and oxidative stress, which participate in the cell transformation process raising the risk of cancer development...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679626/microrna-expression-profile-in-plasma-from-type-1-diabetic-patients-case-control-study-and-bioinformatic-analysis
#11
Taís S Assmann, Mariana Recamonde-Mendoza, Márcia Puñales, Balduíno Tschiedel, Luís H Canani, Daisy Crispim
AIMS: To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved. METHODS: Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29678976/fostering-active-living-and-healthy-eating-through-understanding-physical-activity-and-dietary-behaviours-of-arabic-speaking-adults-a-cross-sectional-study-from-the-middle-east
#12
Tam Truong Donnelly, Tak Shing Fung, Al-Anoud Bint Mohammad Al-Thani
OBJECTIVES: Physical inactivity and unhealthy diets increase the risk for diabetes, cardiovascular diseases and cancer. Many people in Qatar are sedentary and consume diets high in fats, salt and sugar. The purpose of this study was to determine physical activity levels, food habits and understand the variables that might predict physical activity and healthy eating behaviours among Arabic-speaking adults living in the State of Qatar. SETTING: A cross-sectional community-based survey was conducted with 1606 Arab adults ≥18 years of age from March 2013 to June 2015...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677364/long-anterior-lens-zonules-and-intraocular-pressure
#13
Daniel K Roberts, Tricia L Newman, Mary Flynn Roberts, Bruce A Teitelbaum, Janis E Winters
Purpose: To investigate the relation between intraocular pressure (IOP) and the idiopathic long anterior zonule (LAZ) trait. Methods: Patients presenting for primary eye care were examined for LAZ, identified as radially oriented zonular fibers with central extension >1.0 mm beyond the normal anterior lens insertion zone (estimated via slit lamp beam length). Ocular, systemic health, and lifestyle data were collected via comprehensive exam and questionnaire. Multivariate regression was used to assess the relationship between IOP (Goldmann) and LAZ...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677167/the-role-of-catechins-in-cellular-responses-to-oxidative-stress
#14
REVIEW
Jurga Bernatoniene, Dalia Marija Kopustinskiene
Catechins are polyphenolic compounds&mdash;flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29675984/associations-of-pre-existing-co-morbidities-with-skeletal-muscle-mass-and-radiodensity-in-patients-with-non-metastatic-colorectal-cancer
#15
Jingjie Xiao, Bette J Caan, Erin Weltzien, Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Jeffrey A Meyerhardt, Vickie E Baracos, Marilyn L Kwan, Adrienne L Castillo, Carla M Prado
BACKGROUND AND AIM: Co-morbidities and computerized tomography-measured muscle abnormalities are both common in cancer patients and independently adversely influence clinical outcomes. Muscle abnormalities are also evident in other diseases, such as diabetes and obesity. This study examined for the first time the association between co-morbidities and muscle abnormalities in patients diagnosed with colorectal cancer (CRC). METHODS: This cross-sectional study included 3051 non-metastatic patients with Stages I-III CRC...
April 19, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29674970/hypothesis-the-psychedelic-ayahuasca-heals-traumatic-memories-via-a-sigma-1-receptor-mediated-epigenetic-mnemonic-process
#16
Antonio Inserra
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N -Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine oxidase inhibitors (MAOIs) also present in Ayahuasca prevent the degradation of DMT. One peculiarity of SIGMAR1 activation and MAOI activity is the reversal of mnemonic deficits in pre-clinical models...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29673944/liver-disease-in-men-undergoing-androgen-deprivation-therapy-for-prostate-cancer
#17
Philipp Gild, Alexander P Cole, Anna Krasnova, Barbra A Dickerman, Nicolas von Landenberg, Maxine Sun, Lorelei A Mucci, Stuart R Lipsitz, Felix K-H Chun, Paul L Nguyen, Adam S Kibel, Toni K Choueiri, Shehzad Basaria, Quoc-Dien Trinh
PURPOSE: Androgen deprivation therapy is associated with development of diabetes and metabolic syndrome. Its effect on developing non-alcoholic fatty liver disease, a condition frequently co-occuring with metabolic syndrome, and other subsequent liver conditions (liver cirrhosis, hepatic necrosis, any liver disease) has not been investigated.
 MATERIALS & METHODS: We identified 82,938 men aged 66 and older diagnosed with localized prostate cancer within the Surveillance, Epidemiology and End Results- Medicare database, 1992-2009...
April 16, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29673046/newly-diagnosed-type-2-diabetes-may-serve-as-a-potential-marker-for-pancreatic-cancer
#18
Rachel Dankner, Laurence S Freedman, Hertzel Gerstein, Jesse Roth, Lital Keinan-Boker
Pancreatic cancer has an extremely highly case fatality. Diabetes is a well-established strong risk factor for pancreatic cancer. Compared to a non-diabetic population, we previously reported a 15- and 14-fold greater risk for detecting pancreatic cancer during the first year after diagnosing diabetes in adult women and men, respectively, which dropped during the second year to 5.4-fold and 3.5-fold, respectively, and stabilized around 3-fold for the rest of the 11-year follow up in our historical cohort. The population attributable risk (PAR) during the 11-year period was 13...
April 19, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29672754/comorbidity-clusters-in-people-with-gout-an-observational-cohort-study-with-linked-medical-record-review
#19
Megan Bevis, Milisa Blagojevic-Bucknall, Christian Mallen, Samantha Hider, Edward Roddy
Objective: To investigate how comorbid conditions cluster in patients with gout in a UK primary care population. Methods: A cross-sectional study was performed using baseline data from a primary-care-based prospective observational cohort of people aged ⩾18 years with gout. Participants with gout were identified through primary care medical records. Factor analysis was performed to obtain distinct clusters of comorbidity variables including obesity, hypertension, diabetes mellitus, hyperlipidaemia, coronary heart disease, heart failure, chronic kidney disease (CKD) and cancer...
April 17, 2018: Rheumatology
https://www.readbyqxmd.com/read/29671907/a-comprehensive-review-of-phytochemical-profile-bioactives-for-pharmaceuticals-and-pharmacological-attributes-of-azadirachta-indica
#20
REVIEW
Sumaira Saleem, Gulzar Muhammad, Muhammad Ajaz Hussain, Syed Nasir Abbas Bukhari
Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti-inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties...
April 19, 2018: Phytotherapy Research: PTR
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