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https://www.readbyqxmd.com/read/28884018/pp2a-b-holoenzyme-substrate-recognition-regulation-and-role-in-cytokinesis
#1
Cheng-Guo Wu, Hui Chen, Feng Guo, Vikash K Yadav, Sean J Mcilwain, Michael Rowse, Alka Choudhary, Ziqing Lin, Yitong Li, Tingjia Gu, Aiping Zheng, Qingge Xu, Woojong Lee, Eduard Resch, Benjamin Johnson, Jenny Day, Ying Ge, Irene M Ong, Mark E Burkard, Ylva Ivarsson, Yongna Xing
Protein phosphatase 2A (PP2A) is a major Ser/Thr phosphatase; it forms diverse heterotrimeric holoenzymes that counteract kinase actions. Using a peptidome that tiles the disordered regions of the human proteome, we identified proteins containing [LMFI]xx[ILV]xEx motifs that serve as interaction sites for B'-family PP2A regulatory subunits and holoenzymes. The B'-binding motifs have important roles in substrate recognition and in competitive inhibition of substrate binding. With more than 100 novel ligands identified, we confirmed that the recently identified LxxIxEx B'α-binding motifs serve as common binding sites for B' subunits with minor variations, and that S/T phosphorylation or D/E residues at positions 2, 7, 8 and 9 of the motifs reinforce interactions...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28883906/corrigendum-to-propofol-attenuates-small-intestinal-ischemia-reperfusion-injury-through-inhibiting-nadph-oxidase-mediated-mast-cell-activation
#2
Xiaoliang Gan, Dandan Xing, Guangjie Su, Shun Li, Chenfang Luo, Michael G Irwin, Zhengyuan Xia, Haobo Li, Ziqing Hei
[This corrects the article DOI: 10.1155/2015/167014.].
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28800733/integrative-and-quantitive-evaluation-of-the-efficacy-of-his-bundle-related-pacing-in-comparison-with-conventional-right-ventricular-pacing-a-meta-analysis
#3
Ziqing Yu, Ruizhen Chen, Yangang Su, Xueying Chen, Shengmei Qin, Minghui Li, Fei Han, Junbo Ge
BACKGROUND: Long-term RVP could bring adverse problems to cardiac electro-mechanics and result in inter- and intra-ventricular asynchrony, impaired labor force, and aggravation of cardiac function. HBRP including direct His bundle pacing and para-His bundle pacing was regarded as a novel physiological pacing pattern to avoid devastating cardiac function. This synthetic study was conducted to integratively and quantitatively evaluate the efficacy of His bundle related pacing (HBRP) in comparison with conventional right ventricular pacing (RVP)...
August 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28741985/the-influence-of-fasudil-on-renal-proximal-tubular-cell-epithelial-mesenchymal-transition-induced-by-parathormone
#4
Ziqing Gao, Weiping Zhu, Hua Zhang, Zhonghe Li, Tongxia Cui
BACKGROUND: Renal fibrosis is a common pathway through which a variety of chronic kidney diseases progress to end-stage renal disease. Epithelial-mesenchymal transition (EMT) of renal proximal tubular cells is one of the most important factors in renal fibrosis. This study investigates if fasudil could influence EMT of renal proximal tubular cells. METHODS: HK-2 cells in passage 3-4 were used for all experiments. The cells were divided into five groups and treated with different concentrations of PTH and then observe cellular morphological changes at 0, 24 and 48 h using an inverted microscope and investigate the expression of the epithelial cell marker E-cadherin and the renal fibroblast marker α-smooth muscle actin (α-SMA)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28569786/brg1-mediated-nrf2-ho-1-pathway-activation-alleviates-hepatic-ischemia-reperfusion-injury
#5
Mian Ge, Weifeng Yao, Dongdong Yuan, Shaoli Zhou, Xi Chen, Yihan Zhang, Haobo Li, Zhengyuan Xia, Ziqing Hei
Cytoprotective gene heme oxygenase 1 (HO-1) could be induced by nuclear factor E2-related factor 2 (Nrf2) nuclear translocation. The purpose of this study was to determine the role of Brahma-related gene 1 (Brg1), a catalytic subunit of SWI2/SNF2-like chromatin remodeling complexes, in Nrf2/HO-1 pathway activation during hepatic ischemia-reperfusion (HIR). Our results showed that hepatic Brg1 was inhibited during early HIR while Brg1 overexpression reduced oxidative injury in CMV-Brg1 mice subjected to HIR...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28542133/protein-disulfide-isomerase-mediated-apoptosis-and-proliferation-of-vascular-smooth-muscle-cells-induced-by-mechanical-stress-and-advanced-glycosylation-end-products-result-in-diabetic-mouse-vein-graft-atherosclerosis
#6
Suning Ping, Shuying Liu, Yuhuan Zhou, Ziqing Li, Yuhuang Li, Kefeng Liu, Adham Sa Bardeesi, Linli Wang, Jingbo Chen, Lie Deng, Jingjing Wang, Hong Wang, Dadi Chen, Zhengyu Zhang, Puyi Sheng, Chaohong Li
Protein disulfide isomerase (PDI) involves cell survival and death. Whether PDI mediates mechanical stretch stress (SS) and/or advanced glycosylation end products (AGEs) -triggered simultaneous increases in proliferation and apoptosis of vascular smooth muscle cells (VSMCs) is unknown. Here, we hypothesized that different expression levels of PDI trigger completely opposite cell fates among the different VSMC subtypes. Mouse veins were grafted into carotid arteries of non-diabetic and diabetic mice for 8 weeks; the grafted veins underwent simultaneous increases in proliferation and apoptosis, which triggered vein graft arterializations in non-diabetic or atherosclerosis in diabetic mice...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28526819/systematic-comparison-of-2a-peptides-for-cloning-multi-genes-in-a-polycistronic-vector
#7
Ziqing Liu, Olivia Chen, J Blake Joseph Wall, Michael Zheng, Yang Zhou, Li Wang, Haley Ruth Vaseghi, Li Qian, Jiandong Liu
Cloning of multiple genes in a single vector has greatly facilitated both basic and translational studies that require co-expression of multiple factors or multi-units of complex protein. Many strategies have been adopted, among which 2A "self-cleaving" peptides have garnered increased interest for their polycistronic nature, small size and high "cleavage" efficiency. However, broad application of 2 A peptides is limited by the lack of systematic comparison of different 2As alone or in combination. Here we characterized the effect of varying gene position and 2As on the expression of proteins encoded in bi-, tri-, or quad-cistronic constructs...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490871/home-noninvasive-positive-pressure-ventilation-with-built-in-software-in-stable-hypercapnic-copd-a-short-term-prospective-multicenter-randomized-controlled-trial
#8
Luqian Zhou, Xiaoying Li, Lili Guan, Jianhua Chen, Bingpeng Guo, Weiliang Wu, Yating Huo, Ziqing Zhou, Zhenyu Liang, Yuqi Zhou, Jie Tan, Xin Chen, Yuanlin Song, Rongchang Chen
BACKGROUND: The benefits of noninvasive positive pressure ventilation (NPPV) in patients with hypercapnic COPD are controversial. It is presumed that methodology and appropriate use of NIV ventilator might be crucial for the outcomes. With the new built-in software, the performance of NIV can be monitored at home, which can guarantee the compliance and appropriate use. This study investigated effects of home use of NIV in hypercapnia in COPD patients using the NIV ventilator with built-in software for monitoring...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28482473/tribocorrosion-behaviour-of-a-biomedical-ti-25nb-3mo-3zr-2sn-alloy-in-ringer-s-solution
#9
Zhenguo Wang, Weijiu Huang, Yan Li, Haoran He, Yongtao Zhou, Ziqing Zheng
The tribocorrosion behaviour of biomaterial Ti-25Nb-3Mo-3Zr-2Sn alloy in Ringer's solution was evaluated by micro-abrasion experiments, electrochemical tests and scanning electron microscope (SEM) observations. Potentiodynamic polarization results suggested that the effect of particle concentration on the electrochemistry characteristic is greater than the applied load. When the particle concentration and applied load were 0.05g·cm(-3) and 0.25N, respectively, the Ecorr reached the maximum as -0.381V. The micro-abrasion-corrosion results showed that the wear rates of the Ti-25Nb-3Mo-3Zr-2Sn alloy increased with increasing particle concentration and decreased as applied load increased...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28427999/serpinb1-ameliorates-acute-lung-injury-in-liver-transplantation-through-erk1-2-mediated-stat3-dependent-ho-1-induction
#10
Weifeng Yao, Haobo Li, Gangjian Luo, Xiang Li, Chaojin Chen, Dongdong Yuan, Xinjin Chi, Zhengyuan Xia, Ziqing Hei
BACKGROUND: Postoperative acute lung injury (ALI) is a severe complication after liver transplantation, which severely affects postoperative patients' survival. The underlying mechanism is largely unknown and effective treatment limited. We explored the role of serpin protease inhibitor B1 (SERPINB1), a potent inhibitor of neutrophil serine proteases, in ALI in liver transplantation and its interplay with signal transducer and activator of transcription 3 (STAT3) and heme oxygenase-1 (HO-1)...
April 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28401647/mg53-anchored-by-dysferlin-to-cell-membrane-reduces-hepatocyte-apoptosis-which-induced-by-ischaemia-reperfusion-injury-in%C3%A2-vivo-and-in%C3%A2-vitro
#11
Weifeng Yao, Haobo Li, Xue Han, Chaojin Chen, Yihan Zhang, Wai Lydia Tai, Zhengyuan Xia, Ziqing Hei
Hepatic ischaemia/reperfusion (HIR) induces severe damage on hepatocyte cell membrane, which leads to hepatocyte death and the subsequent HIR injury. In this study, we investigated the role and the mechanism of mitsugumin-53 (MG53), a novel cell membrane repair protein, in protecting the liver against HIR injury. Rats were subjected to sham operation or 70% warm HIR with or without recombined MG53 (rhMG53), caudal vein-injected 2 hrs before inducing HIR. In vitro, cultured hepatocyte AML12 cells were subjected to hypoxia/reoxygenation (H/R) in the presence of rhMG53 and/or dysferlin gene shRNAs or adenovirus transfection...
April 12, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28349955/a-canine-model-of-tracheal-stenosis-induced-by-cuffed-endotracheal-intubation
#12
Zhuquan Su, Shiyue Li, Ziqing Zhou, Xiaobo Chen, Yingying Gu, Yu Chen, Changhao Zhong, Minglu Zhong, Nanshan Zhong
Postintubation tracheal stenosis is a complication of endotracheal intubation. The pathological mechanism and risk factors for endotracheal intubation-induced tracheal stenosis remain not fully understood. We aimed to establish an animal model and to investigate risk factors for postintubation tracheal stenosis. Beagles were intubated with 4 sized tubes (internal diameter 6.5 to 8.0 mm) and cuff pressures of 100 to 200 mmHg for 24 hr. The status of tracheal wall was evaluated by bronchoscopic and histological examinations...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28294182/asymmetric-dimethylarginine-and-all-cause-mortality-a-systematic-review-and-meta-analysis
#13
Shaoli Zhou, Qianqian Zhu, Xiang Li, Chaojin Chen, Jiping Liu, Yuping Ye, Ying Ruan, Ziqing Hei
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), impairs the beneficial effect of NO. The predictive value of ADMA for all-cause mortality remains controversial, though it is important in the development of cardiovascular disease (CVD) and progression to dialysis in renal disease. This systematic review and meta-analysis was conducted to investigate the association between circulating ADMA and all-cause mortality. Studies with data pertinent to the association between circulating ADMA and all-cause mortality were reviewed and OR, HR or RR with 95% CI derived from multivariate Cox's proportional-hazards analysis were extracted...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28281560/electro-echocardiographic-indices-to-predict-cardiac-resynchronization-therapy-non-response-on-non-ischemic-cardiomyopathy
#14
Ziqing Yu, Xueying Chen, Fei Han, Shengmei Qin, Minghui Li, Yuan Wu, Yangang Su, Junbo Ge
Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a retrospective study to review a total of 227 patients of dyssynchronous heart failure underwent CRT implantation. Logistic analysis was performed between CRT responders and CRT non-responders...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28128553/peptide-22-and-cyclic-rgd-functionalized-liposomes-for-glioma-targeting-drug-delivery-overcoming-bbb-and-bbtb
#15
Cuitian Chen, Ziqing Duan, Yan Yuan, Ruixiang Li, Liang Pang, Jianming Liang, Xinchun Xu, Jianxin Wang
Chemotherapy outcomes for the treatment of glioma remain unsatisfied due to the inefficient drug transport across BBB/BBTB and poor drug accumulation in the tumor site. Nanocarriers functionalized with different targeting ligands are considered as one of the most promising alternatives. However, few studies were reported to compare the targeting efficiency of the ligands and develop nanoparticles to realize BBB/BBTB crossing and brain tumor targeting simultaneously. In this study, six peptide-based ligands (Angiopep-2, T7, Peptide-22, c(RGDfK), D-SP5 and Pep-1), widely used for brain delivery, were selected to decorate liposomes, respectively, so as to compare their targeting ability to BBB or BBTB...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28111726/ganetespib-overcomes-resistance-to-parp-inhibitors-in-breast-cancer-by-targeting-core-proteins-in-the-dna-repair-machinery
#16
Juhong Jiang, Yuanzhi Lu, Zhi Li, Liping Li, Daoli Niu, Wenwei Xu, Jing Liu, Lin Fu, Ziqing Zhou, Yingying Gu, Fen Xia
DNA damage repair plays essential roles in drug resistance, especially resistance to Poly (ADP-ribose) polymerase (PARP) inhibitors in the clinic. A subset of DNA repair proteins such as Breast cancer gene 1 (BRCA1), BRCA2 and RecA homolog (RAD51) are client proteins of heat shock protein 90 (Hsp90). Clearance of these DNA repair proteins by inhibition of Hsp90 is a promising strategy for overcoming resistance to PARP inhibitors. Here we report the pharmacological analysis of the highly potent second-generation Hsp90 inhibitor, ganetespib...
June 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/27809301/phospholipase-d1-regulated-autophagy-supplies-free-fatty-acids-to-counter-nutrient-stress-in-cancer-cells
#17
Ming Cai, Jingquan He, Jian Xiong, Li Wei Rachel Tay, Ziqing Wang, Colin Rog, Jingshu Wang, Yizhao Xie, Guobin Wang, Yoshiko Banno, Feng Li, Michael Zhu, Guangwei Du
Cancer cells utilize flexible metabolic programs to maintain viability and proliferation under stress conditions including nutrient deprivation. Here we report that phospholipase D1 (PLD1) participates in the regulation of metabolic plasticity in cancer cells. PLD1 activity is required for cancer cell survival during prolonged glucose deprivation. Blocking PLD1 sensitizes cancer cells to glycolysis inhibition by 2-deoxy-D-glucose (2-DG) and results in decreased autophagic flux, enlarged lysosomes, and increased lysosomal pH...
November 3, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27806303/hydroxyurea-mediated-cytotoxicity-without-inhibition-of-ribonucleotide-reductase
#18
Li Phing Liew, Zun Yi Lim, Matan Cohen, Ziqing Kong, Lisette Marjavaara, Andrei Chabes, Stephen D Bell
In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of the hyperthermophilic archaeon Sulfolobus solfataricus with HU, we observe dose-dependent cell cycle arrest, accumulation of DNA double-strand breaks, stalled replication forks, and elevated levels of recombination structures. However, Sulfolobus has a HU-insensitive class II ribonucleotide reductase, and we reveal that HU treatment does not significantly impact cellular DNA precursor pools...
November 1, 2016: Cell Reports
https://www.readbyqxmd.com/read/27514369/multiple-systemic-embolism-in-infective-endocarditis-underlying-in-barlow-s-disease
#19
Ziqing Yu, Bing Fan, Hongyi Wu, Xiangfei Wang, Chenguang Li, Rende Xu, Yangang Su, Junbo Ge
BACKGROUND: Systemic embolism, especially septic embolism, is a severe complication of infective endocarditis (IE). However, concurrent embolism to the brain, coronary arteries, and spleen is very rare. Because of the risk of hemorrhage or visceral rupture, anticoagulants are recommended only if an indication is present, e.g. prosthetic valve. Antiplatelet therapy in IE is controversial, but theoretically, this therapy has the potential to prevent and treat thrombosis and embolism in IE...
August 11, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27464115/real-time-experimental-demonstration-of-ps-qpsk-transmission-with-manipulated-rotating-and-novel-correlated-cma
#20
Haibo Li, Tao Zeng, Jie Li, Feng Jiang, Ziqing Liu, Rong Hu, Ming Luo, Yuanxiang Wang, Xiang Li, Qi Yang, Shaohua Yu, Liyan Huang, Li Cao
In this paper, we propose a novel manipulated rotating polarization switched quadrature phase shift keying (MR-PS-QPSK) technique, and corresponding correlated constant modulus algorithm (CMA) for signal recovery. The latter utilizes the correlation between the PS-QPSK symbols in the two polarizations to lock the phase of output signals. Then the signals in the two polarizations are merged according to the recovered switching bit, which suppresses the noise and simplifies the subsequent process. A field programmable gate array (FPGA) based real-time platform is built for experimental demonstration...
July 25, 2016: Optics Express
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