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https://www.readbyqxmd.com/read/28294182/asymmetric-dimethylarginine-and-all-cause-mortality-a-systematic-review-and-meta-analysis
#1
Shaoli Zhou, Qianqian Zhu, Xiang Li, Chaojin Chen, Jiping Liu, Yuping Ye, Ying Ruan, Ziqing Hei
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), impairs the beneficial effect of NO. The predictive value of ADMA for all-cause mortality remains controversial, though it is important in the development of cardiovascular disease (CVD) and progression to dialysis in renal disease. This systematic review and meta-analysis was conducted to investigate the association between circulating ADMA and all-cause mortality. Studies with data pertinent to the association between circulating ADMA and all-cause mortality were reviewed and OR, HR or RR with 95% CI derived from multivariate Cox's proportional-hazards analysis were extracted...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28281560/electro-echocardiographic-indices-to-predict-cardiac-resynchronization-therapy-non-response-on-non-ischemic-cardiomyopathy
#2
Ziqing Yu, Xueying Chen, Fei Han, Shengmei Qin, Minghui Li, Yuan Wu, Yangang Su, Junbo Ge
Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a retrospective study to review a total of 227 patients of dyssynchronous heart failure underwent CRT implantation. Logistic analysis was performed between CRT responders and CRT non-responders...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28128553/peptide-22-and-cyclic-rgd-functionalized-liposomes-for-glioma-targeting-drug-delivery-overcoming-bbb-and-bbtb
#3
Cuitian Chen, Ziqing Duan, Yan Yuan, Ruixiang Li, Liang Pang, Jianming Liang, Xinchun Xu, Jianxin Wang
Chemotherapy outcomes for the treatment of glioma remain unsatisfied due to the inefficient drug transport across BBB/BBTB and poor drug accumulation in the tumor site. Nanocarriers functionalized with different targeting ligands are considered as one of the most promising alternatives. However, few studies were reported to compare the targeting efficiency of the ligands and develop nanoparticles to realize BBB/BBTB crossing and brain tumor targeting simultaneously. In this study, six peptide-based ligands (Angiopep-2, T7, Peptide-22, c(RGDfK), D-SP5 and Pep-1), widely used for brain delivery, were selected to decorate liposomes, respectively, so as to compare their targeting ability to BBB or BBTB...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28111726/ganetespib-overcomes-resistance-to-parp-inhibitors-in-breast-cancer-by-targeting-core-proteins-in-the-dna-repair-machinery
#4
Juhong Jiang, Yuanzhi Lu, Zhi Li, Liping Li, Daoli Niu, Wenwei Xu, Jing Liu, Lin Fu, Ziqing Zhou, Yingying Gu, Fen Xia
DNA damage repair plays essential roles in drug resistance, especially resistance to Poly (ADP-ribose) polymerase (PARP) inhibitors in the clinic. A subset of DNA repair proteins such as Breast cancer gene 1 (BRCA1), BRCA2 and RecA homolog (RAD51) are client proteins of heat shock protein 90 (Hsp90). Clearance of these DNA repair proteins by inhibition of Hsp90 is a promising strategy for overcoming resistance to PARP inhibitors. Here we report the pharmacological analysis of the highly potent second-generation Hsp90 inhibitor, ganetespib...
January 23, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/27809301/phospholipase-d1-regulated-autophagy-supplies-free-fatty-acids-to-counter-nutrient-stress-in-cancer-cells
#5
Ming Cai, Jingquan He, Jian Xiong, Li Wei Rachel Tay, Ziqing Wang, Colin Rog, Jingshu Wang, Yizhao Xie, Guobin Wang, Yoshiko Banno, Feng Li, Michael Zhu, Guangwei Du
Cancer cells utilize flexible metabolic programs to maintain viability and proliferation under stress conditions including nutrient deprivation. Here we report that phospholipase D1 (PLD1) participates in the regulation of metabolic plasticity in cancer cells. PLD1 activity is required for cancer cell survival during prolonged glucose deprivation. Blocking PLD1 sensitizes cancer cells to glycolysis inhibition by 2-deoxy-D-glucose (2-DG) and results in decreased autophagic flux, enlarged lysosomes, and increased lysosomal pH...
November 3, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27806303/hydroxyurea-mediated-cytotoxicity-without-inhibition-of-ribonucleotide-reductase
#6
Li Phing Liew, Zun Yi Lim, Matan Cohen, Ziqing Kong, Lisette Marjavaara, Andrei Chabes, Stephen D Bell
In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of the hyperthermophilic archaeon Sulfolobus solfataricus with HU, we observe dose-dependent cell cycle arrest, accumulation of DNA double-strand breaks, stalled replication forks, and elevated levels of recombination structures. However, Sulfolobus has a HU-insensitive class II ribonucleotide reductase, and we reveal that HU treatment does not significantly impact cellular DNA precursor pools...
November 1, 2016: Cell Reports
https://www.readbyqxmd.com/read/27514369/multiple-systemic-embolism-in-infective-endocarditis-underlying-in-barlow-s-disease
#7
Ziqing Yu, Bing Fan, Hongyi Wu, Xiangfei Wang, Chenguang Li, Rende Xu, Yangang Su, Junbo Ge
BACKGROUND: Systemic embolism, especially septic embolism, is a severe complication of infective endocarditis (IE). However, concurrent embolism to the brain, coronary arteries, and spleen is very rare. Because of the risk of hemorrhage or visceral rupture, anticoagulants are recommended only if an indication is present, e.g. prosthetic valve. Antiplatelet therapy in IE is controversial, but theoretically, this therapy has the potential to prevent and treat thrombosis and embolism in IE...
August 11, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27464115/real-time-experimental-demonstration-of-ps-qpsk-transmission-with-manipulated-rotating-and-novel-correlated-cma
#8
Haibo Li, Tao Zeng, Jie Li, Feng Jiang, Ziqing Liu, Rong Hu, Ming Luo, Yuanxiang Wang, Xiang Li, Qi Yang, Shaohua Yu, Liyan Huang, Li Cao
In this paper, we propose a novel manipulated rotating polarization switched quadrature phase shift keying (MR-PS-QPSK) technique, and corresponding correlated constant modulus algorithm (CMA) for signal recovery. The latter utilizes the correlation between the PS-QPSK symbols in the two polarizations to lock the phase of output signals. Then the signals in the two polarizations are merged according to the recovered switching bit, which suppresses the noise and simplifies the subsequent process. A field programmable gate array (FPGA) based real-time platform is built for experimental demonstration...
July 25, 2016: Optics Express
https://www.readbyqxmd.com/read/27448695/aromatic-hydrocarbon-receptor-suppresses-prostate-cancer-bone-metastasis-cells-induced-vasculogenesis-of-endothelial-progenitor-cells-under-hypoxia
#9
Shuai Huang, Yuanqing Guo, Angela Jacobi, Ziqing Li, Sheng Huang, Jianan He, Xingmo Liu, Yubo Tang
BACKGROUND/AIMS: Hypoxia leads to the development of neovascularization in solid tumor by regulating VEGF expression. Aromatic hydrocarbon receptor (AHR), a receptor for dioxin-like compounds, functions as a transcription factor through dimerization with hypoxia-inducible factors 1β (HIF-1β) and inhibits the secretion of vascular endothelial growth factor (VEGF). The purpose of this study was to explore whether AHR can suppress hypoxia-induced VEGF production in prostate bone metastasis cells and repress neovascularization in endothelial progenitor cells (EPCs), and, if so, through what mechanisms...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27375835/lipoxin-a4-preconditioning-attenuates-intestinal-ischemia-reperfusion-injury-through-keap1-nrf2-pathway-in-a-lipoxin-a4-receptor-independent-manner
#10
Xue Han, Weifeng Yao, Zipeng Liu, Haobo Li, Zhong-Jun Zhang, Ziqing Hei, Zhengyuan Xia
Oxidative stress plays a critical role in the pathogenesis of intestinal ischemia reperfusion (IIR) injury. Enhancement in endogenous Lipoxin A4 (LXA4), a potent antioxidant and mediator, is associated with attenuation of IIR. However, the effects of LXA4 on IIR injury and the potential mechanisms are unknown. In a rat IIR (ischemia 45 minutes and subsequent reperfusion 6 hours) model, IIR caused intestinal injury, evidenced by increased serum diamine oxidase, D-lactic acid, intestinal-type fatty acid-binding protein, and the oxidative stress marker 15-F2t-Isoprostane...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27322262/weighted-global-artificial-bee-colony-algorithm-makes-gas-sensor-deployment-efficient
#11
Ye Jiang, Ziqing He, Yanhai Li, Zhengyi Xu, Jianming Wei
This paper proposes an improved artificial bee colony algorithm named Weighted Global ABC (WGABC) algorithm, which is designed to improve the convergence speed in the search stage of solution search equation. The new method not only considers the effect of global factors on the convergence speed in the search phase, but also provides the expression of global factor weights. Experiment on benchmark functions proved that the algorithm can improve the convergence speed greatly. We arrive at the gas diffusion concentration based on the theory of CFD and then simulate the gas diffusion model with the influence of buildings based on the algorithm...
2016: Sensors
https://www.readbyqxmd.com/read/27276818/-free-croin-flap-for-repairing-defects-of-donor-after-toe-tissue-transplantation
#12
Muwei Li, Luo Zhaohui, Hannan Gu, Lifeng Ma, Yanjun Yang, Ziqing Zhang
OBJECTIVE: To discuss the effectiveness of free croin flap in repairing defects of donor after toe or feetissue flap transplantation. METHODS: Between March 2010 and May 2015, 23 cases of defects of donor after toe or feet tissue flap transplantation were repaired with free croin flap and followed up for more than 6 months, and the clinical data were retrospectively analyzed. There were 15 males and 8 females, with an age range from 17 to 52 years (mean, 25.6 years)...
February 2016: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/27225075/mitochondrial-dna-typing-of-laser-captured-single-sperm-cells-to-differentiate-individuals-in-a-mixed-semen-stain
#13
Lu Zhang, Mei Ding, Hao Pang, Jiaxin Xing, Jinfeng Xuan, Chunhong Wang, Ziqing Lin, Song Han, Kewei Liang, Chunmei Li, Jun Yao, Baojie Wang
The identification of individuals in a mixture of two semen samples usually involves an analysis of autosomal and Y chromosomal short tandem repeats (STR) which can exclude unrelated individuals but cannot achieve the purpose of individual identification. In sperm cells, there are multiple copies of mitochondrial DNAs (mtDNA) which exhibit genetic polymorphisms in different matrilineal-related individuals. Single-cell capture technology can be applied to obtain some single sperm cells in a mixed semen sample, then polymerase chain reaction can be employed to amplify the mtDNA hypervariable region I (HVR I) from each cell...
August 2016: Electrophoresis
https://www.readbyqxmd.com/read/27044562/construction-of-a-metabolomics-profile-of-arsenic-trioxide-effect-in-gastric-carcinoma-cell-line-sgc7901
#14
Ziqing Chen, Hainan Zhang, Lina Yang, Hewei Jiang, Shujuan Guo, Yang Li, Shengce Tao
Arsenic trioxide (ATO) is highly effective for treating acute promyelocytic leukemia. It also holds the promise for treating solid tumors, including gastric carcinoma. However, the molecular mechanism of the effectiveness of ATO to solid tumor is still poorly understood. In this study, we chosed gastric carcinoma as an example and tried to reveal the antitumor mechanism through metabolomics. Gastric carcinoma cell line SGC7901 was treated with ATO for 6, 12, and 24 h. The global metabolite profiles were monitored by metabolomics analysis using gas chromatography (GC)/mass spectrometry (MS) and liquid chromatography/MS/MS...
May 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/26957038/re-patterning-of-h3k27me3-h3k4me3-and-dna-methylation-during-fibroblast-conversion-into-induced-cardiomyocytes
#15
Ziqing Liu, Olivia Chen, Michael Zheng, Li Wang, Yang Zhou, Chaoying Yin, Jiandong Liu, Li Qian
Direct conversion of fibroblasts into induced cardiomyocytes (iCMs) offers an alternative strategy for cardiac disease modeling and regeneration. During iCM reprogramming, the starting fibroblasts must overcome existing epigenetic barriers to acquire the CM-like chromatin pattern. However, epigenetic dynamics along this reprogramming process have not been studied. Here, we took advantage of our recently generated polycistronic system and determined the dynamics of two critical histone marks, H3K27me3 and H3K4me3, in parallel with gene expression at a set of carefully selected cardiac and fibroblast loci during iCM reprogramming...
March 2016: Stem Cell Research
https://www.readbyqxmd.com/read/26942853/bmi1-is-a-key-epigenetic-barrier-to-direct-cardiac-reprogramming
#16
Yang Zhou, Li Wang, Haley Ruth Vaseghi, Ziqing Liu, Rui Lu, Sahar Alimohamadi, Chaoying Yin, Ji-Dong Fu, Greg G Wang, Jiandong Liu, Li Qian
Direct reprogramming of induced cardiomyocytes (iCMs) suffers from low efficiency and requires extensive epigenetic repatterning, although the underlying mechanisms are largely unknown. To address these issues, we screened for epigenetic regulators of iCM reprogramming and found that reducing levels of the polycomb complex gene Bmi1 significantly enhanced induction of beating iCMs from neonatal and adult mouse fibroblasts. The inhibitory role of Bmi1 in iCM reprogramming is mediated through direct interactions with regulatory regions of cardiogenic genes, rather than regulation of cell proliferation...
March 3, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/26878849/resveratrol-protects-against-titanium-particle-induced-aseptic-loosening-through-reduction-of-oxidative-stress-and-inactivation-of-nf-%C3%AE%C2%BAb
#17
Guotian Luo, Ziqing Li, Yu Wang, Haixing Wang, Ziji Zhang, Weishen Chen, Yangchun Zhang, Yinbo Xiao, Chaohong Li, Ying Guo, Puyi Sheng
Aseptic implant loosening is closely associated with chronic inflammation induced by implant wear debris, and reactive oxygen species (ROS) play an important role in this process. Resveratrol, a plant compound, has been reported to act as an antioxidant in many inflammatory conditions; however, its protective effect and mechanism against wear particle-induced oxidative stress remain unknown. In this study, we evaluated resveratrol's protective effects against wear particle-induced oxidative stress in RAW 264...
April 2016: Inflammation
https://www.readbyqxmd.com/read/26813635/pmd-a-resource-for-archiving-and-analyzing-protein-microarray-data
#18
Zhaowei Xu, Likun Huang, Hainan Zhang, Yang Li, Shujuan Guo, Nan Wang, Shi-Hua Wang, Ziqing Chen, Jingfang Wang, Sheng-Ce Tao
Protein microarray is a powerful technology for both basic research and clinical study. However, because there is no database specifically tailored for protein microarray, the majority of the valuable original protein microarray data is still not publically accessible. To address this issue, we constructed Protein Microarray Database (PMD), which is specifically designed for archiving and analyzing protein microarray data. In PMD, users can easily browse and search the entire database by experimental name, protein microarray type, and sample information...
January 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26670486/advanced-glycation-end-products-biphasically-modulate-bone-resorption-in-osteoclast-like-cells
#19
Ziqing Li, Chaohong Li, Yuhuan Zhou, Weishen Chen, Guotian Luo, Ziji Zhang, Haixing Wang, Yangchun Zhang, Dongliang Xu, Puyi Sheng
Advanced glycation end products (AGEs) disturb bone remodeling during aging, and this process is accelerated in diabetes. However, their role in modulation of osteoclast-induced bone resorption is controversial, with some studies indicating that AGEs enhance bone resorption and others showing the opposite effect. We determined whether AGEs present at different stages of osteoclast differentiation affect bone resorption differently. Based on increased levels of tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CTSK), we identified day 4 of induction as the dividing time of cell fusion stage and mature stage in RAW264...
March 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26649751/improved-generation-of-induced-cardiomyocytes-using-a-polycistronic-construct-expressing-optimal-ratio-of-gata4-mef2c-and-tbx5
#20
Li Wang, Ziqing Liu, Chaoying Yin, Yang Zhou, Jiandong Liu, Li Qian
Direct conversion of cardiac fibroblasts (CFs) into induced cardiomyocytes (iCMs) holds great potential for regenerative medicine by offering alternative strategies for treatment of heart disease. This conversion has been achieved by forced expression of defined factors such as Gata4 (G), Mef2c (M) and Tbx5 (T). Traditionally, iCMs are generated by a cocktail of viruses expressing these individual factors. However, reprogramming efficiency is relatively low and most of the in vitro G,M,T-transduced fibroblasts do not become fully reprogrammed, making it difficult to study the reprogramming mechanisms...
2015: Journal of Visualized Experiments: JoVE
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