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https://www.readbyqxmd.com/read/29749508/interleukin%C3%A2-1%C3%AE-%C3%A2-mediated-suppression-of-microrna%C3%A2-27a%C3%A2-3p-activity-in-human-cartilage-via-mapk-and-nf%C3%A2-%C3%AE%C2%BAb-pathways-a-potential-mechanism-of-osteoarthritis-pathogenesis
#1
Xing Li, Peiheng He, Ziqing Li, Haixing Wang, Minghao Liu, Yinbo Xiao, Dongliang Xu, Yan Kang, Hua Wang
The aim of the present study was to investigate the role of microRNA (miR)‑27a‑3p in osteoarthritis (OA). Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed to determine the expression of miR‑27a‑3p and aggrecanase‑2 (ADAMTS5) in cartilage tissues from patients with OA and healthy controls, and also in interleukin (IL)‑1β‑treated primary human chondrocytes. Primary human chondrocytes were transfected with miR‑27a‑3p. A luciferase reporter assay was used to validate the direct contact between miR‑27a‑3p and its putative binding site in the 3'‑untranslated region ADAMTS5 mRNA...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29743891/a-loss-of-function-screen-of-epigenetic-modifiers-and-splicing-factors-during-early-stage-of-cardiac-reprogramming
#2
Yang Zhou, Sahar Alimohamadi, Li Wang, Ziqing Liu, Joseph B Wall, Chaoying Yin, Jiandong Liu, Li Qian
Direct reprogramming of cardiac fibroblasts (CFs) to induced cardiomyocytes (iCMs) is a newly emerged promising approach for cardiac regeneration, disease modeling, and drug discovery. However, its potential has been drastically limited due to the low reprogramming efficiency and largely unknown underlying molecular mechanisms. We have previously screened and identified epigenetic factors related to histone modification during iCM reprogramming. Here, we used shRNAs targeting an additional battery of epigenetic factors involved in chromatin remodeling and RNA splicing factors to further identify inhibitors and facilitators of direct cardiac reprogramming...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29728804/sphk-2-promotes-the-particle-induced-inflammation-of-raw264-7-by-maintaining-consistent-expression-of-tnf-%C3%AE-and-il-6
#3
Guangpu Yang, Minghui Gu, Weishen Chen, Wenhua Liu, Yinbo Xiao, Haixing Wang, Weiming Lai, Guoyan Xian, Ziji Zhang, Ziqing Li, Puyi Sheng
Aseptic implant loosening is a devastating long-term complication of total joint arthroplasty. It is mainly initiated by the interaction of wear debris and macrophages. However, how does the chronic inflammation persist and how to stop it is poorly understood. Sphingosine kinases (SPHKs) are an essential feature of immunosuppressive M2 polarisation in macrophages and a promoter for chronic inflammation. In this study, RAW 264.7 macrophages were exposed to stimulation with titanium particles (0.1 mg/ml), and the subsequent expression of SPHKs and pro-inflammatory cytokines was evaluated...
May 4, 2018: Inflammation
https://www.readbyqxmd.com/read/29531018/the-effect-of-earthworm-extract-on-promoting-skin-wound-healing
#4
Zhenhan Deng, Jianjian Yin, Wei Luo, Ronak Naveenchandra Kotian, Shanshan Gao, Ziqing Yi, Wenfeng Xiao, Wenping Li, Yusheng Li
Chronic non-healing wounds pose a significant challenge to health-care system because of its tremendous utilization of resources and time to heal. It has a well-deserved reputation for reducing the quality of life for those affected and represents a substantial economic burden to the health-care system overall. Earthworms are used as a traditional Chinese medicine, and have been applied pharmacologically and clinically since a long time in China. However, there is paucity in data regarding its wound healing effects...
March 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29526015/allele-frequencies-of-18-autosomal-str-loci-in-the-uyghur-population-living-in-kashgar-prefecture-northwest-china
#5
Jian Zhang, Zhenghui Li, Xiaoting Mo, Wenhua Ma, Hantao Zhang, Ziqing Lin, Jian Ye
There is currently no large population data-based data set in Kashgar Prefecture Uyghur. The allele frequencies of 18 autosomal short tandem repeat (STR) loci included in the DNATyper™ 19 kit were evaluated in 2600 Uyghur individuals living in Kashgar Prefecture, Northwest China. The values of combined power of discrimination (CPD) and combined probability of exclusion (CPE) of all 18 autosomal STR loci were 0.99999999999999999998235 and 0.99999998670, respectively. Phylogenetic analyses revealed that the Uyghur population has a closer relationship with the Xinjiang-Kazakh, Inner Mongolia-Mongolian, and other three Uyghur populations...
March 10, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29497305/intraoperative-dexmedetomidine-attenuates-postoperative-systemic-inflammatory-response-syndrome-in-patients-who-underwent-percutaneous-nephrolithotomy-a-retrospective-cohort-study
#6
Fang Tan, Xiaoliang Gan, Yingqing Deng, Xiaoyun Li, Na Guo, Ziqing Hei, Qianqian Zhu, Zhuang-Gui Chen, Shaoli Zhou
Purpose: Dexmedetomidine (DEX) has been reported to attenuate inflammation in rats. The present retrospective cohort study aimed to investigate whether intraoperative administration with DEX could reduce the incidence of postoperative systemic inflammatory response syndrome (SIRS) in patients following percutaneous nephrolithotomy (PCNL). Patients and methods: A total of 251 patients were included in the analysis. Among these patients, 175 received intravenous DEX infusion during the intraoperative period and 76 did not...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29465586/yiqifumai-injection-for-chronic-heart-failure-protocol-for-a-systematic-review-and-meta-analysis
#7
REVIEW
Yuanping Wang, Xiaohui Li, Ziqing Li, Yu Zhang, Dawei Wang
BACKGROUND: Chronic heart AQ4 failure (CHF) is the final stage of various heart diseases. YiQiFuMai injection (YQFMI) has been widely applied in the treatment of CHF. However, to our knowledge, there has been no systematic review or meta-analysis of randomized controlled trails (RCTs) regarding the effectiveness of this treatment. Here, we provide a protocol to evaluate the efficacy and safety of YQFMI for CHF. METHODS: To evaluate the clinical efficacy of YQFMI in treating CHF, 2 researcher members will independently search the RCTs in the following 8 Chinese and English databases, in which the data collection will be from the time when the respective databases were established to January 2018...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29399929/electrocardiographic-parameters-effectively-predict-ventricular-tachycardia-fibrillation-in-acute-phase-and-abnormal-cardiac-function-in-chronic-phase-of-st-segment-elevation-myocardial-infarction
#8
Ziqing Yu, Zhangwei Chen, Yuan Wu, Ruizhen Chen, Minghui Li, Xueying Chen, Shengmei Qin, Yixiu Liang, Yangang Su, Junbo Ge
BACKGROUND: Abnormal cardiac repolarization is closely associated with ventricular tachycardia/ventricular fibrillation (VT/VF). Myocardial ischemia and infarction aggravate cardiac repolarization dispersion, and VT/VF could be lethal in the early stage of ST-segment elevation myocardial infarction (STEMI). Unfortunately, VT/VF cannot be effectively predicted in current clinical practice. The present study aimed to assess electrocardiographic parameters of the sinus rhythmic complex in relation to cardiac repolarization, e...
February 5, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29390369/acupuncture-for-vertebrobasilar-insufficiency-vertigo-protocol-for-a-systematic-review-and-meta-analysis
#9
REVIEW
Xiaohui Li, Menghui Liu, Yu Zhang, Ziqing Li, Dawei Wang, Xia Yan
BACKGROUND: Vertebrobasilar insufficiency vertebrobasilar (VBIV) is a serious nerve disease and many old people suffer from it. Acupuncture has been widely applied in the treatment of VBIV. However, to our knowledge, there has been no systematic review or meta-analysis of randomized controlled trails regarding the effectiveness of this treatment. Here, we provide a protocol to evaluate the effectiveness and safety of acupuncture for VBIV. METHODS: Relevant randomized controlled trials in 5 databases (EMBASE, PubMed, the Cochrane Central Register of Controlled Trials [Cochrane Library], Chinese Biomedical Literature Database [CBM], China National Knowledge Infrastructure [CNKI]) will be comprehensively searched by 2 researchers in December 2017...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390351/chinese-herbal-medicine-for-patients-with-atrial-fibrillation-protocol-for-a-systematic-review-and-meta-analysis
#10
REVIEW
Xiaoli Cai, Yuanping Wang, Ziqing Li, Yu Zhang, Dawei Wang, Xia Yan
BACKGROUND: Atrial fibrillation (AF) is the most clinically common cardiac arrhythmia. Chinese herbal medicine (CHM) has been widely applied in the treatment of AF, However, to our knowledge, there has been no systematic review and meta-analysis of randomized controlled trails (RCTs) regarding the effectiveness of this treatment. Therefore, we provide a protocol to evaluate the effectiveness and safety of CHM for AF. METHODS: The databases reviewed to collect RCTs related to CHM treatment for AF will be as follows: 3 English literature databases, which are PubMed, Embase, and Cochrane Library, and 3 Chinese literature databases, which are CBM, CNKI, and Wanfang...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29361784/identification-of-a-common-different-gene-expression-signature-in-ischemic-cardiomyopathy
#11
Yana Li, Qiu Jiang, Zhiwen Ding, Guijian Liu, Peng Yu, Guoliang Jiang, Ziqing Yu, Chunjie Yang, Juying Qian, Hong Jiang, Yunzeng Zou
The molecular mechanisms underlying the development of ischemic cardiomyopathy (ICM) remain poorly understood. Gene expression profiling is helpful to discover the molecular changes taking place in ICM. The aim of this study was to identify the genes that are significantly changed during the development of heart failure caused by ICM. The differentially expressed genes (DEGs) were identified from 162 control samples and 227 ICM patients. PANTHER was used to perform gene ontology (GO), and Reactome for pathway enrichment analysis...
January 22, 2018: Genes
https://www.readbyqxmd.com/read/29356513/role-of-synthesis-method-on-luminescence-properties-of-europium-ii-iii-ions-in-%C3%AE-ca-2-sio-4-probing-local-site-and-structure
#12
Rajaboopathi Mani, Huaidong Jiang, Santosh Kumar Gupta, Ziqing Li, Xiulan Duan
The europium ion probes the symmetry disorder in the crystal structure, although the distortion due to charge compensation in the case of aliovalent dopant remains interesting, especially preparation involves low and high temperatures. This work studies the preparation of the β-Ca2 SiO4 (from here on C2 S) particle from Pechini (C2 SP) and hydrothermal (C2 SH) methods, and its luminescence variance upon doping with Eu2+ and Eu3+ ions. The blue shift of the charge-transfer band (CTB) in the excitation spectra indicates a larger Eu3+ -O2- distance in Eu3+ doped C2 SH...
February 5, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29296507/periodic-microstructures-of-blood-capillaries-revealed-by-synchrotron-x-ray-multi-resolution-microscopic-analysis
#13
Shengkun Yao, Yunbing Zong, Xu Huang, Yang Liu, Ningqiang Gong, Jianhua Zhang, Ziqing Li, Feng Cao, Xiangcheng Wang, Xing-Jie Liang, Huaidong Jiang
Cardiovascular diseases are closely related to structural blood capillaries lesions. Herein, microscopic investigations of mouse blood capillaries were performed at multiple spatial resolution by using synchrotron X-ray in-line phase contrast tomography and scanning transmission X-ray microscopy (STXM). The chemically fixed blood capillaries without any contrast agents were selected. For the first time, a periodic bamboo-shaped structure was observed at nanoscale resolution by STXM, and the three-dimensional tomographic slices at sub-micrometer resolution further confirmed the periodic wave profile of the blood capillaries...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29151122/genetic-polymorphisms-in-18-autosomal-str-loci-in-the-tibetan-population-living-in-tibet-chamdo-southwest-china
#14
Zhenghui Li, Jian Zhang, Hantao Zhang, Ziqing Lin, Jian Ye
Short tandem repeats (STRs) play a vitally important role in forensics. Population data is needed to improve the field. There is currently no large population data-based data set in Chamdo Tibetan. In our study, the allele frequencies and forensic statistical parameters of 18 autosomal STR loci (D5S818, D21S11, D7S820, CSF1PO, D2S1338, D3S1358, VWA, D8S1179, D16S539, PentaE, TPOX, TH01, D19S433, D18S51, FGA, D6S1043, D13S317, and D12S391) included in the DNATyper™19 kit were investigated in 2249 healthy, unrelated Tibetan subjects living in Tibet Chamdo, Southwest China...
May 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29072293/single-cell-transcriptomics-reconstructs-fate-conversion-from-fibroblast-to-cardiomyocyte
#15
Ziqing Liu, Li Wang, Joshua D Welch, Hong Ma, Yang Zhou, Haley Ruth Vaseghi, Shuo Yu, Joseph Blake Wall, Sahar Alimohamadi, Michael Zheng, Chaoying Yin, Weining Shen, Jan F Prins, Jiandong Liu, Li Qian
Direct lineage conversion offers a new strategy for tissue regeneration and disease modelling. Despite recent success in directly reprogramming fibroblasts into various cell types, the precise changes that occur as fibroblasts progressively convert to the target cell fates remain unclear. The inherent heterogeneity and asynchronous nature of the reprogramming process renders it difficult to study this process using bulk genomic techniques. Here we used single-cell RNA sequencing to overcome this limitation and analysed global transcriptome changes at early stages during the reprogramming of mouse fibroblasts into induced cardiomyocytes (iCMs)...
November 2, 2017: Nature
https://www.readbyqxmd.com/read/29067438/mirna-140-inhibits-c3h10t1-2-mesenchymal-stem-cell-proliferation-by-targeting-cxcl12-during-transforming-growth-factor-%C3%AE-3-induced-chondrogenic-differentiation
#16
Qingde Wa, Yi Liu, Shuai Huang, Peiheng He, Jianwei Zuo, Xing Li, Ziqing Li, Liming Dong, Jiachen Peng, Shuhong Wu, Fang Chen, Dongfeng Cai, Xuenong Zou, Wenbo Liao
The aim of the present study was to investigate the role of microRNA (miRNA or miR)-140 in C3H10T1/2 mesenchymal stem cells (MSCs). Cluster analysis was used to evaluate the miRNA expression profile. The expression level of miRNA‑140 was validated by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). TargetScan and microRNA.org databases were used to predict target miRNAs and cartilage‑associated target genes. Binding sites between miR‑140 and the target gene were predicted by bioinformatics software...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29058723/electrophilic-probes-for-deciphering-substrate-recognition-by-o-glcnac-transferase
#17
Chia-Wei Hu, Matthew Worth, Dacheng Fan, Baobin Li, Hao Li, Lei Lu, Xiaofang Zhong, Ziqing Lin, Liming Wei, Ying Ge, Lingjun Li, Jiaoyang Jiang
O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential human glycosyltransferase that adds O-GlcNAc modifications to numerous proteins. However, little is known about the mechanism with which OGT recognizes various protein substrates. Here we report on GlcNAc electrophilic probes (GEPs) to expedite the characterization of OGT-substrate recognition. Data from mass spectrometry, X-ray crystallization, and biochemical and radiolabeled kinetic assays support the application of GEPs to rapidly report the impacts of OGT mutations on protein substrate or sugar binding and to discover OGT residues crucial for protein recognition...
December 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29033361/binding-of-pld2-generated-phosphatidic-acid-to-kif5b-promotes-mt1-mmp-surface-trafficking-and-lung-metastasis-of-mouse-breast-cancer-cells
#18
Ziqing Wang, Feng Zhang, Jingquan He, Ping Wu, Li Wei Rachel Tay, Ming Cai, Weiqi Nian, Yuanyuan Weng, Li Qin, Jeffrey T Chang, Laura B McIntire, Gilbert Di Paolo, Jianming Xu, Junmin Peng, Guangwei Du
Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D2 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model. PLD2 promotes local invasion through the regulation of the plasma membrane targeting of MT1-MMP and its associated invadopodia. A liposome pull-down screen identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-binding protein...
October 23, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28954220/comparative-gene-expression-analyses-reveal-distinct-molecular-signatures-between-differentially-reprogrammed-cardiomyocytes
#19
Yang Zhou, Li Wang, Ziqing Liu, Sahar Alimohamadi, Chaoying Yin, Jiandong Liu, Li Qian
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) or directly reprogrammed from non-myocytes (induced cardiomyocytes [iCMs]) are promising sources for heart regeneration or disease modeling. However, the similarities and differences between iPSC-CMs and iCMs are still unknown. Here, we performed transcriptome analyses of beating iPSC-CMs and iCMs generated from cardiac fibroblasts (CFs) of the same origin. Although both iPSC-CMs and iCMs establish CM-like molecular features globally, iPSC-CMs exhibit a relatively hyperdynamic epigenetic status, whereas iCMs exhibit a maturation status that more closely resembles that of adult CMs...
September 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/28884018/pp2a-b-holoenzyme-substrate-recognition-regulation-and-role-in-cytokinesis
#20
Cheng-Guo Wu, Hui Chen, Feng Guo, Vikash K Yadav, Sean J Mcilwain, Michael Rowse, Alka Choudhary, Ziqing Lin, Yitong Li, Tingjia Gu, Aiping Zheng, Qingge Xu, Woojong Lee, Eduard Resch, Benjamin Johnson, Jenny Day, Ying Ge, Irene M Ong, Mark E Burkard, Ylva Ivarsson, Yongna Xing
Protein phosphatase 2A (PP2A) is a major Ser/Thr phosphatase; it forms diverse heterotrimeric holoenzymes that counteract kinase actions. Using a peptidome that tiles the disordered regions of the human proteome, we identified proteins containing [LMFI]xx[ILV]xEx motifs that serve as interaction sites for B'-family PP2A regulatory subunits and holoenzymes. The B'-binding motifs have important roles in substrate recognition and in competitive inhibition of substrate binding. With more than 100 novel ligands identified, we confirmed that the recently identified LxxIxEx B'α-binding motifs serve as common binding sites for B' subunits with minor variations, and that S/T phosphorylation or D/E residues at positions 2, 7, 8 and 9 of the motifs reinforce interactions...
2017: Cell Discovery
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