Xiao Huang, Jialing Zhao, Qinghua Wang, Tingqi Yan, Shu Gou, Xiaofeng Zhu, Liu Yang, Fang Ye, Jie Zhang, Yanjiang Wang, Shaojie Yang, Weidong Le, Yang Xiang
AIMS: Recent evidence indicated the biological basis of complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) 3, 4, and 14 for affecting brain structure and cognitive function. Thus, we aimed to investigate the association between plasma CTRPs with Alzheimer's disease (AD). METHODS: A multicenter, cross-sectional study recruited patients with AD (n = 137) and cognitively normal (CN) controls (n = 140). After the data collection of demographic characteristics, lifestyle risk factors, and medical history, plasma levels of tau phosphorylated at threonine 217 (pT217), pT181, neurofilament light (NfL), CTRP3, 4, and 14 were examined and compared...
February 2024: CNS Neuroscience & Therapeutics