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Paul Swinburn, Andrew Lloyd, K S Boye, Emily Edson-Heredia, Lee Bowman, Bas Janssen
OBJECTIVES: The EuroQol five-dimensional (EQ-5D) questionnaire is a generic measure widely used for the assessment of health status. Research has suggested that it may be insensitive to the burdens associated with particular conditions. This study was designed to explore the feasibility of developing and valuing a disease-specific "bolt-on" version of the EQ-5D questionnaire for use in psoriasis. METHODS: A series of steps were undertaken to develop, test, and evaluate dimensions for a psoriasis-specific version of the EQ-5D questionnaire (hereafter referred to as the EQ-PSO questionnaire)...
December 2013: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Rita Nemr, Amira Turki, Akram Echtay, Ghadeer S Al-Zaben, Hoda S Daher, Noha A Irani-Hakime, Sose H Keleshian, Wassim Y Almawi
We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.
December 2012: Diabetes Research and Clinical Practice
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