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Shatha Hussain Ali, Salman Hussain Assi, Fadhil S Hussien
Hypertension (HTN) is one of the most common sequelae of chronic kidney disease (CKD) in children. Dialysis-related HTN is predominantly caused by chronic volume overload, and as such the blood pressure (BP) can be reduced and/or brought down to normal in a sizable number of patients with improved salt and fluid balance. This study was conducted to assess the prevalence of HTN among children on hemodialysis (HD) and to evaluate the correlation of HTN with some demographic data. This is a prospective study performed on forty pediatric patients with CKD receiving maintenance HD in three centers in Baghdad...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
Reza Hekmat, Faeze Maghsudloo, Mahmood Mohebi, Sayed Abdolrahim Rezaee, Rosita Vakili, Hoshang Rafat Panah
Sexual dysfunction (SD) is a common problem in patients with the end-stage renal disease. In contrast to SD in males, relatively little work has been performed in the field of SD in females. In this study, we tried to identify the main determinants of SD in women aged 15-45year-old on chronic hemodialysis (HD). One hundred-forty female patients aged 15-45-year-old on chronic HD were studied in the winter of the year 2013. Healthy relatives of the patients were chosen as controls and matched for age, level of education, marital status, and income...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
Masami Saito, Kiyotaka Iwasaki
Our aim was to conduct a scoping review of the regulations for hemodialyzers in the safety evaluation in Japan and the United States, and to evaluate the criteria for premarketing clinical trials and postmarketing safety reports to inform the development of a sophisticated premarketing evaluation in Japan. Regulations for approval of hemodialyzers were identified from the databases of the Ministry of Health, Labor and Welfare in Japan and the Federal Drug Agency (FDA) in the United States (US). The criteria for premarket clinical trials and postmarketing safety reports were evaluated for both countries...
October 5, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Sandra Wagner, Mugurel Apetrii, Ziad A Massy, Kleber E Marcus, Graciela E Delgado, Scharnagel Hubert, März Winfried, Marie Metzger, Patrick Rossignol, Alan Jardine, Hallvard Holdaas, Bengt Fellström, Roland Schmieder, Bénédicte Stengel, Faiez Zannad
Statin treatment reduces the risk of cardiovascular mortality in the general population, but it has little or no benefit in hemodialyzed patients (HD). This may reflect different underlying pathophysiology of CVD in patients treated with HD, maybe involving the oxidative stress. Our aim was to assess the association of oxidized LDL (oxLDL), determinated by Mercodia oxLDL ELISA Kit, with major adverse cardiac events (MACE) and all-cause mortality in HD patients based on the AURORA trial (rosuvastatin vs placebo), and patients not on HD from the LURIC study...
September 25, 2016: Free Radical Research
Katherine N Gharibian, Venkatesh L Murthy, Bruce A Mueller
BACKGROUND: Regadenoson is a novel pharmacological stress agent whose disposition during hemodialysis is not known. The purpose of this study was to determine the clearance of regadenoson under varying dialytic conditions using an in vitro hemodialysis model. METHODS AND RESULTS: Whole human blood was used to analyze the effect of hemodialysis on the clearance of regadenoson. Regadenoson transmembrane clearance (CLD) was assessed for both a standard permeability and a high permeability polysulfone hemodialyzer with blood/dialysate flow rates of 300/600 and 400/800 mL/min...
September 15, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Teresa Kurzawa, Aleksander Owczarek, Joanna K Strzelczyk, Karolina Gołąbek, Andrzej Wiczkowski
BACKGROUND: Chronic renal disease constitutes a serious worldwide clinical problem. An important issue arising early during the treatment of renal failure is anemia. Patients in the end-stage of renal disease chronically treated with hemodialysis frequently suffer from anemia with iron deficiency. OBJECTIVES: The aim of the study was to evaluate the usefulness of determining the reticulocyte hemoglobin content and serum concentration of soluble transferrin receptor in the detection of anemia caused by iron deficiency in comparison with the classic markers of iron circulation in serum in chronic dialysis patients with ESRD...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Robert S Brown, Bhanu K Patibandla, Alexander S Goldfarb-Rumyantzev
Patients needing hemodialysis are advised to have arteriovenous fistulas rather than catheters because of significantly lower mortality rates. However, disparities in fistula placement raise the possibility that patient factors have a role in this apparent mortality benefit. We derived a cohort of 115,425 patients on incident hemodialysis ≥67 years old from the US Renal Data System with linked Medicare claims to identify the first predialysis vascular access placed. We compared mortality outcomes in patients initiating hemodialysis with a fistula placed first, a catheter after a fistula placed first failed, or a catheter placed first (n=90,517; reference group)...
September 7, 2016: Journal of the American Society of Nephrology: JASN
Luis Manjarres, Pilar Sanchez, María C Cabezas, Marco Fornasini, Valeria Freire, Adelin Albert
BACKGROUND: Chronic kidney disease (CKD) is a disorder with high morbidity and mortality worldwide whose complications generate multiple costs. In Ecuador, only a few healthcare institutions have implemented management protocols aimed to reduce costs and to improve the quality of life of patients. The aim of this study is to evaluate the short-term (1-year) and long-term (5-year) costs and savings in the management of secondary hyperparathyroidism (SHPT) of hemodialyzed CKD patients by comparing calcitriol and paricalcitol in a large social security hospital in Quito, Ecuador...
2016: BMC Health Services Research
Etienne Cavalier, Pierre Lukas, Anne-Catherine Bekaert, Agnès Carlisi, Caroline Le Goff, Pierre Delanaye, Jean-Claude Souberbielle
BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated immunoassays and against a VDSP-traceable liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in six different populations. We also supplemented 40 healthy volunteers with either 600,000 IU of vitamin D2 or 100,000 of vitamin D3 to evaluate the performance of the immunoassays vs...
August 13, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Ryo Koda, Hirofumi Watanabe, Noriaki Iino
No abstract text is available yet for this article.
August 10, 2016: Therapeutic Apheresis and Dialysis
Takatoshi Kakuta, Hirotaka Komaba, Nobuyoshi Takagi, Yuichiro Takahashi, Hajime Suzuki, Toru Hyodo, Mikako Nagaoka, Reika Tanaka, Soichiro Iwao, Mari Ishida, Hiroyuki Kobayashi, Akira Saito, Masafumi Fukagawa
We compared interleukin-6 (IL-6) removal and induction between conventional polysulfone (Con) and TORAYLIGHT NV (NV) dialyzers in hemodialysis patients. Twenty patients on Con with high IL-6 concentrations (2.7-8.5 pg/mL) were randomized to Con or NV group. Dialyzer performance was determined in NV group while patients were on Con and after being switched onto NV. Erythropoiesis-stimulating agent (ESA) response index (ERI) was assessed every 4 months for one year. IL-6 clearance was comparable between Con and NV...
August 8, 2016: Therapeutic Apheresis and Dialysis
Lidia Maroñas-Jiménez, Sara Burillo-Martínez, Enrique Morales, Maria Concepción Garrido-Ruiz, Jose Luis Rodríguez-Peralto
No abstract text is available yet for this article.
July 12, 2016: American Journal of Dermatopathology
Céline Heimburger, Gerlinde Averous, Emmanuelle Charlin, Hervé Lang, Jean-Emmanuel Kurtz, Alessio Imperiale
We report the surprising intense uptake of F-FDOPA in a right adrenal metastasis of a poorly differentiated metastatic adenocarcinoma of unknown primary mimicking a pheochromocytoma in a hemodialyzed patient with the typical Menard's triad and increased serum catecholamines. Our observation emphasizes that F-FDOPA is not a specific radiotracer for pheochromocytoma and paraganglioma investigation, although it is currently and successfully used in this clinical setting. Moreover, we underline that kidney failure may be responsible for abnormally high serum catecholamines values even in subjects without pheochromocytoma, leading to erroneous diagnostic conclusions particularly in patients with adrenal masses...
September 2016: Clinical Nuclear Medicine
Cosimo Chelazzi, Gianluca Villa, Maria Grazia D'Alfonso, Paola Mancinelli, Guglielmo Consales, Margherita Berardi, Angelo Raffaele De Gaudio, Stefano Romagnoli
BACKGROUND: Hemodialysis with high cut-off continuous veno-venous hemodialyzer (HCO-CVVHD) removes mediators of organ dysfunction during sepsis. This study assessed the clinical effects of HCO-CVVHD as compared to high-flux (HF) membranes during gram-negative sepsis. METHODS: Intensive care unit (ICU), septic patients treated with HCO-CVVHD or HF-CVVHDF for AKI were retrospectively observed (January 2013-December 2014). Mechanical ventilation, vasopressors' requirements, ICU length of stay (LOS) and ICU in-hospital mortality were compared between groups...
2016: Blood Purification
Amel Chebel, Régine Catallo, Céline Mabon, Emmanuel Bachy, Thomas Wenner, Gilles Salles, Claire Pouteil-Noble, Martine Ffrench
Several studies reported the benefits of switching from anticalcineurins to mTOR inhibitors to avoid cancer occurrence after organ transplantation. The purpose of our study was to determine in vivo biological markers to explain these benefits. Cellular changes related to cellular senescence and DNA damage were analyzed in peripheral blood lymphocytes. Thirty-five kidney transplanted patients receiving anticalcineurins were investigated: 17 patients were proposed to switch to rapamycin and 18 patients with similar age and transplantation duration, continued anticalcineurins...
September 2016: European Journal of Cell Biology
Stéphane Jaisson, Isabelle Kazes, Aurore Desmons, Fouad Fadel, Jean-Baptiste Oudart, Izabella C R Dos Santos-Weiss, Hervé Millart, Fatouma Touré, Philippe Rieu, Philippe Gillery
BACKGROUND: Homocitrulline (HCit) is a carbamylation-derived product (CDP) that has been identified as a valuable biomarker of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of this study was to determine whether initiation of hemodialysis therapy (HD) could induce variations of HCit concentrations in CKD patients. METHODS: Serum HCit concentrations were determined by LC-MS/MS in CKD patients (n=108) just before (M0) and six months (M6) after the initiation of HD therapy...
September 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Javad Velayeti, Azad Reza Mansourian, Mohammad Mojerloo, Abdoljalal Marjani
AIMS: The aim of this study focused on serum malondialdehyde (MDA) levels and erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities in hemodialysis patients and compared with control groups. MATERIALS AND METHODS: Forty-five hemodialyzed patients and 45 control groups recruited in this study. Serum creatinine and urea, thyroid hormones (THs) levels and erythrocyte antioxidant enzyme activities were determined. RESULTS: Hemodialysis (HD) patients showed higher levels of MDA than control groups (P < 0...
May 2016: Indian Journal of Endocrinology and Metabolism
Anna Lorenzin, Francesco Garzotto, Alberta Alghisi, Mauro Neri, Dario Galeano, Stefania Aresu, Antonello Pani, Enrico Vidal, Zaccaroa Ricci, Luisa Murer, Stuart L Goldstein, Claudio Ronco
BACKGROUND: The CARdiorenal PEDIatric EMergency (CARPEDIEM) machine was originally designed to perform only continuous venovenous hemofiltration (CVVH) in neonatal and pediatric patients. In some cases, adequate convective clearance may not be reached because of a limited blood flow. In such conditions, the application of diffusive clearance [continuous venovenous hemodialysis (CVVHD)] would help optimize blood purification. In this study, the CARPEDIEM™ machine was modified to enable the circulation of dialysis through the filter allowing testing of the performance of CARPEDIEM™ machine in CVVHD...
October 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Marek Kuźniewski, Danuta Fedak, Paulina Dumnicka, Ewa Stępień, Beata Kuśnierz-Cabala, Marcin Cwynar, Władysław Sułowicz
PURPOSE: The high prevalence of cardiovascular morbidity and mortality among patients with chronic kidney disease (CKD) is observed especially in those undergoing dialysis. Osteoprotegerin (OPG) and its ligands, receptor activator of nuclear factor kappa-B ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) have been associated with cardiovascular complications. Our aim was to study their role as cardiovascular risk factors in stage 5 CKD patients. PATIENTS AND METHODS: OPG, RANKL and TRAIL concentrations were measured in 69 hemodialyzed CKD patients and 35 healthy volunteers...
March 21, 2016: Advances in Medical Sciences
Satoshi Noda, Daiki Hira, Susumu Kageyama, Fumiyasu Jo, Akinori Wada, Tetsuya Yoshida, Akihiro Kawauchi, Shin-Ya Morita, Tomohiro Terada
No abstract text is available yet for this article.
August 2016: Clinical Genitourinary Cancer
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