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Hemodialyzers

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https://www.readbyqxmd.com/read/29774568/effects-of-plasma-proteins-on-the-transport-and-surface-characteristics-of-polysulfone-polyethersulfone-and-asymmetric-cellulose-triacetate-high-flux-dialyzers
#1
Tae Ryung Kim, Mahsa Hadidi, Seyed Pouria Motevalian, Takashi Sunohara, Andrew L Zydney
Blood-membrane interactions can have a large impact on the performance of hemodialysis membranes, particularly for high flux membranes in which the membrane itself provides very low resistance to solute transport. The objective of this study was to examine the effects of exposure to serum on the solute clearance and convective sieving characteristics of high flux polysulfone (Optiflux F250NR), polyethersulfone (ELISIO-25H), and asymmetric cellulose triacetate (SOLACEA-25H) hemodialyzers using both vitamin B12 and a range of polydisperse dextrans...
May 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29745004/heparin-free-renal-replacement-therapy-for-chronic-hemodialyzed-patients-at-high-risk-for-bleeding-a-comparison-of-on-line-predilution-hemodiafiltration-with-conventional-hemodialysis
#2
Vincent Brunot, Jean-Emmanuel Serre, Georges Mourad, Kada Klouche, Vincent Pernin
BACKGROUND: In chronic hemodialysis patients with high risk of bleeding, optimal anticoagulation of the extracorporeal circuit is challenging. Heparin-free hemodialysis (HD) with heparin-coated AN69ST dialyzer is now considered as a good option and recommended by experts. Predilutional hemodiafiltration (HDF) may represent also a feasible alternative but has been poorly investigated. In this study, our aim was to evaluate the performance of on-line automated predilution heparin-free HDF as compared to conventional heparin-free HD with a heparin-coated membrane...
May 10, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29722112/the-development-of-central-venous-thrombosis-in-hemodialyzed-patients-is-associated-with-catheter-tip-depth-and-localization
#3
Vedran Premuzic, Drazen Perkov, Ranko Smiljanic
INTRODUCTION: The aim of our work was to analyze the incidence of tunneled hemodialysis catheters-related thrombosis in hemodialyzed patients depending on catheter tip depth and position and to evaluate the impact of other established risk factors responsible for development of central venous thrombosis. METHODS: The presence of central vein thrombosis, location, and the depth of the catheter tip was reviewed by two experienced radiologists. All patients with suspected central venous thrombosis had factor V Leiden, lupus anticoagulant, and cardiolipin antibodies checked (acIgM and acIgG) and were evaluated with cat-scan venography...
May 2, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29651959/central-to-peripheral-arterial-stiffness-gradient-in-hemodialyzed-patients-depends-on-the-location-of-the-upper-limb-vascular-access
#4
Daniel Bia, Cintia Galli, Yanina Zocalo, Rodolfo Valtuille, Sandra Wray, Franco Pessana, Edmundo I Cabrera-Fischer
Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained in the side of the body where the VA was placed and compare them to its contralateral intact side...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651958/arterial-stiffness-in-haemodialysed-patients-findings-and-controversies
#5
Edmundo I Cabrera-Fischer, Yanina Zocalo, Sandra Wray, Daniel Bia
Vascular research in end-stage renal diseases is an interesting field in which the characterization of arterial stiffness proved to be valuable to predict morbidity and mortality. Particularly, patients in renal replacement therapy have been reported to have significant increases of arterial stiffness and cardiovascular mortality. The clinical relevance of the measurement of arterial stiffness is linked to therapeutical and preventive interventions. The purpose of this work is to analyze the results of the scientific research in the field of arterial stiffness, in which hemodialyzed patients were involved, emphasizing on clinical and in-vitro research carried out by our group compared to contributions previously reported in the specialized literature...
April 12, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29627823/alterations-in-serum-microrna-profile-during-hemodialysis-potential-biological-implications
#6
Dorota Trzybulska, Dag Eckersten, Aleksander Giwercman, Anders Christensson, Christos Tsatsanis
BACKGROUND/AIMS: Hemodialysis implies significant alterations in the profile of serum components. microRNAs (miRNAs) are present in the human serum and are considered to target distant tissues where they can regulate gene expression, thus affecting homeostasis. Whether hemodialysis alters the profile of miRNAs in the serum is not known. METHODS: miRNA profiling in serum samples collected before and after hemodialysis was performed using miRNA qPCR arrays. The results were subsequently validated in an independent group of 10 hemodialyzed men...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29554100/alterations-in-conformational-state-of-albumin-in-plasma-in-chronic-hemodialyzed-patients
#7
Anna Pieniazek, Lukasz Gwozdzinski, Zbigniew Zbrog, Krzysztof Gwozdzinski
OBJECTIVE: In chronic hemodialyzed (CH) patients the balance between production of reactive oxygen species and antioxidant defense system is disturbed and shifted towards oxidative conditions. The properties of albumin in CH patients were studied before hemodialysis (HD) and post-HD. METHODS: Two oxidants were applied, organic t-butyl hydroperoxide (t-BOOH) and inorganic hydroperoxide (H2O2), for oxidation of albumin molecules. By comparison, albumin from healthy donors was also modified by both oxidants...
2018: PloS One
https://www.readbyqxmd.com/read/29511057/hemodiafiltration-to-address-unmet-medical-needs-eskd-patients
#8
Bernard Canaud, Jörg Vienken, Stephen Ash, Richard A Ward
Hemodiafiltration combines diffusive and convective solute removal in a single therapy by ultrafiltering 20% or more of the blood volume processed using a high-flux hemodialyzer and maintaining fluid balance by infusing sterile nonpyrogenic replacement fluid directly into the patient's blood. In online hemodiafiltration, the large volumes of replacement fluid required are obtained by online filtration of standard dialysate through a series of bacteria- and endotoxin-retaining filters. Currently available systems for online hemodiafiltration are on the basis of conventional dialysis machines with added features to safely prepare and infuse replacement fluid and closely control fluid balance...
March 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29501417/establishment-of-reference-values-in-a-healthy-population-and-interpretation-of-serum-pth-concentrations-in-hemodialyzed-patients-according-to-the-kdigo-guidelines-using-the-lumipulse%C3%A2-g-whole-pth-3rd-generation-assay
#9
Etienne Cavalier, Margot Salsé, Anne-Marie Dupuy, Anne-Sophie Bargnoux, Florence Watar, Jean-Claude Souberbielle, Pierre Delanaye, Jean-Paul Cristol
BACKGROUND: 3rd generation PTH assays only detect the bioactive 1-84 fragment. Since standardization is still lacking, each new PTH assay requires to establish reference values and to assess the impact in the medical care of the mineral and bone disorders in hemodialyzed patients. METHODS: Using Fujirebio Lumipulse G wPTH assay, serum PTH levels were measured in a population of 439 healthy subjects from France and Belgium PTH levels were also determined in 119 hemodialyzed patients...
April 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29422614/micro-computed-tomography-for-the-quantification-of-blocked-fibers-in-hemodialyzers
#10
Floris Vanommeslaeghe, Wim Van Biesen, Manuel Dierick, Matthieu Boone, Annemieke Dhondt, Sunny Eloot
A novel technique based on micro-CT scanning is developed to quantify coagulation in fibers of hemodialyzers. This objectivation is needed to allow accurate assessment of thrombogenicity of dialyzers used during hemodialysis, for example when comparing different strategies to avoid coagulation and/or fiber blocking. The protocol allowed imaging at a resolution of 25 µm, making it possible to count the open, non-coagulated fibers in a non-invasive way. In 3 fresh, non-used FX600 hemodialyzers, patent fiber counts were extremely consistent (10748 ± 2)...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29419935/treatment-of-acute-kidney-injury-associated-with-cyclosporine-overdose-in-a-dog-using-hemodialysis-and-charcoal-hemoperfusion
#11
Gilad Segev, Larry D Cowgill
OBJECTIVE: To describe the management of cyclosporine overdose using hemodialysis and hemoperfusion in a dog. CASE SUMMARY: A 6-year-old, spayed female Australian Shepherd was presented for treatment of cyclosporine overdose and acute kidney injury. Five days prior to presentation, the dog had been diagnosed by its referring veterinarian with immune-mediated thrombocytopenia. Treatment was initiated with prednisone, but since no response was noted, azathioprine (50 mg PO q 24 h) and cyclosporine (6 mg/kg IV q 24 h) were added...
March 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29411069/the-utility-of-frax%C3%A2-in-predicting-bone-fractures-in-patients-with-chronic-kidney-disease-on-hemodialysis-a-two-year-prospective-multicenter-cohort-study
#12
J Przedlacki, J Buczyńska-Chyl, P Koźmiński, E Niemczyk, E Wojtaszek, E Gieglis, P Żebrowski, A Podgórzak, J Wściślak, M Wieliczko, J Matuszkiewicz-Rowińska
We assessed the FRAX® method in 718 hemodialyzed patients in estimating increased risk of bone major and hip fractures. Over two prospective years, statistical analysis showed that FRAX® enables a better assessment of bone major fracture risk in these patients than any of its components and other risk factors considered in the analysis. INTRODUCTION: Despite the generally increased risk of bone fractures among patients with end-stage renal disease, no prediction models for identifying individuals at particular risk have been developed to date...
February 6, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29341167/the-influence-of-colloid-osmotic-pressure-on-hydrostatic-pressures-in-high-and-low-flux-hemodialyzers
#13
Daniel Schneditz, Georgios Sarikakis, Maria Kontodima, Notburga Sauseng
The aim of this study was to examine the relationship between hydrostatic trans-membrane pressure (TMPh ) and colloid osmotic pressure (COP) in low-flux (LF) and high-flux (HF) dialyzers. Hydrostatic pressures were measured in dialyzers distinguished by their ultrafiltration coefficient Kuf (16 and 85 mL/h/mm Hg) under constant dialysate flow and variable blood flow (Qb ) ranging from 0 to 400 mL/min using (i) alginate (70 kDa) dissolved in dialysate, (ii) diluted, undiluted, and concentrated plasma, or (iii) whole blood at different hematocrit, all in absence of ultrafiltration (UF)...
January 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29324682/malnutrition-inflammation-atherosclerosis-syndrome-mia-and-diet-recommendations-among-end-stage-renal-disease-patients-treated-with-maintenance-hemodialysis
#14
Małgorzata Maraj, Beata Kuśnierz-Cabala, Paulina Dumnicka, Agnieszka Gala-Błądzińska, Katarzyna Gawlik, Dorota Pawlica-Gosiewska, Anna Ząbek-Adamska, Małgorzata Mazur-Laskowska, Piotr Ceranowicz, Marek Kuźniewski
Malnutrition-inflammation-atherosclerosis syndrome is one of the causes of increased mortality in chronic kidney disease (CKD). The aim of the study was to assess the inflammation and nutritional status of patients in end-stage kidney disease treated with maintenance hemodialysis. The study included a group of 98 hemodialyzed patients with stage 5 CKD (38 women and 60 men). Albumin, prealbumin (PRE), and C-reactive protein (CRP) were measured in serum samples collected before mid-week dialysis. Fruit and vegetables frequency intakes were assessed with a questionnaire...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29296087/examining-hemodialyzer-membrane-performance-using-proteomic-technologies
#15
REVIEW
Mario Bonomini, Luisa Pieroni, Lorenzo Di Liberato, Vittorio Sirolli, Andrea Urbani
The success and the quality of hemodialysis therapy are mainly related to both clearance and biocompatibility properties of the artificial membrane packed in the hemodialyzer. Performance of a membrane is strongly influenced by its interaction with the plasma protein repertoire during the extracorporeal procedure. Recognition that a number of medium-high molecular weight solutes, including proteins and protein-bound molecules, are potentially toxic has prompted the development of more permeable membranes. Such membrane engineering, however, may cause loss of vital proteins, with membrane removal being nonspecific...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29193165/precise-quantitative-assessment-of-the-clinical-performances-of-two-high-flux-polysulfone-hemodialyzers-in-hemodialysis-validation-of-a-blood-based-simple-kinetic-model-versus-direct-dialysis-quantification
#16
Paik-Seong Lim, Yuyu Lin, Minfeng Chen, Xiaoqi Xu, Yun Shi, Sudhir Bowry, Bernard Canaud
Highly permeable dialysis membranes with better design filters have contributed to improved solute removal and dialysis efficacy. However, solute membrane permeability needs to be well controlled to avoid increased loss of albumin that is considered to be detrimental for dialysis patients. A novel high-flux dialyzer type (FX CorDiax; Fresenius Medical Care) incorporating an advanced polysulfone membrane modified with nano-controlled spinning technology to enhance the elimination of a broader spectrum of uremic toxins has been released...
November 27, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29159509/the-role-of-socio-demographic-factors-in-depression-and-anxiety-of-patients-on-hemodialysis-an-observational-cross-sectional-study
#17
G Gerogianni, E Lianos, A Kouzoupis, M Polikandrioti, E Grapsa
PURPOSE: Depression and anxiety have high prevalence in patients on hemodialysis and are strongly associated with socio-economic factors. The aim of this study was to evaluate the prevalence of depression and anxiety in hemodialyzed patients in Greece and its association with socio-demographic factors. METHODS: Four hundred and fourteen (414) patients on hemodialysis (262 males and 152 females) from 24 dialysis centers in Greece participated in this observational cross-sectional study...
January 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29144096/long-term-treatment-with-etanercept-monotherapy-in-a-hemodialyzed-patient-with-moderate-to-severe-plaque-type-psoriasis-and-psoriatic-arthritis
#18
Graziella Babino, Maria Esposito, Luca Bianchi, Alessandro Giunta
No abstract text is available yet for this article.
November 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29109360/investigation-of-the-pronounced-erythropoietin-induced-reduction-in-hyperglycemia-in-type-1-like-diabetic-rats
#19
Shu-Chun Kuo, Yingxiao Li, Kai-Chun Cheng, Chiang-Shan Niu, Juei-Tang Cheng, Ho-Shan Niu
Erythropoietin (EPO) is known to stimulate erythropoiesis after binding with its specific receptor. In clinics, EPO is widely used in hemodialyzed patients with diabetes. However, changes in the expression of the erythropoietin receptor (EPOR) under diabetic conditions are still unclear. Therefore, we investigated EPOR expression both in vivo and in vitro. Streptozotocin-induced type 1-like diabetic rats (STZ rats) were used to evaluate the blood glucose-lowering effects of EPO. The expression and activity of the transducer and activator of transcription 3 (STAT3), the potential signaling molecule, was investigated in cultured rat skeletal myoblast (L6) cells incubated in high-glucose (HG) medium to mimic the in vivo changes...
February 26, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29067238/lipid-disorders-in-patients-with-renal-failure-role-in-cardiovascular-events-and-progression-of-chronic-kidney-disease
#20
REVIEW
Luca Visconti, Salvatore Benvenga, Antonio Lacquaniti, Valeria Cernaro, Annamaria Bruzzese, Giovanni Conti, Michele Buemi, Domenico Santoro
The spectrum of lipid disorders in chronic kidney disease (CKD) is usually characterized by high triglycerides and reduced high dense lipoprotein (HDL), associated with normal or slightly reduced low dense lipoprotein (LDL)-cholesterol. This dyslipidemia is associated with an increased risk for atherosclerotic cardiovascular disease. Keys for the cardiovascular risk reduction in these patients are lowering the number and modifying the composition of the cholesterol-carrying atherogenic lipoprotein particles...
December 2016: Journal of Clinical & Translational Endocrinology
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