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Dry eye and diabetes

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https://www.readbyqxmd.com/read/27888572/adverse-effect-profile-of-topical-ocular-administration-of-fingolimod-for-treatment-of-dry-eye-disease
#1
Weibao Xiao, Li Sun, Nan Zhang, Wen Ye
Fingolimod is a promising prodrug in attenuating multiple sclerosis and prolonging survival of organ allograft, with many other protective effects. Its mechanism of action is related to the internalization of sphingosine 1-phosphate receptors (S1PRs). Our previous study indicated that fingolimod eyedrop was efficacious in inhibiting ocular inflammation in a dry eye disease (DED) model of Non-Obese Diabetic (NOD) mice. In the current study, we evaluated potential adverse effects of fingolimod eyedrop. Inbred 10-week-old BALB/C mice were randomly divided into four groups, fingolimod-treated groups at three different concentrations (0...
November 26, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27853013/ocular-manifestations-of-type-1-diabetes-mellitus-in-pediatric-population
#2
Handan Akil, Ayse Derya Buluş, Nesibe Andiran, Mehmet Numan Alp
CONTEXT: To evaluate the necessity of ocular screening in Type 1 diabetes mellitus (DM). AIMS: This study aims to investigate the diabetes-related ocular changes according to the glycosylated hemoglobin (HbA1c) level and duration of diabetes in children and compare the results with nondiabetic healthy children. SETTINGS AND DESIGN: Observational cross-sectional study designed by ophthalmology and pediatric endocrinology clinics. SUBJECTS AND METHODS: Forty-two children with Type 1 DM, 42 healthy gender- and age-matched children as controls were enrolled...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27815675/-what-can-anti-vegf-therapy-achieve-in-clinical-routine-effectiveness-of-anti-vegf-therapy-in-patients-with-macular-diseases-in-clinical-routine-on-1492-eyes-in-austria
#3
K Wiesinger, P Reinelt, A Ennemoser, M Edelmayr, U Schönherr
BACKGROUND: The aim of this user observational study was to illustrate the effectiveness of intravitreal operative medication administration (IVOM) in the clinical routine. DESIGN: A monocentric, single arm, prospective study. MATERIAL AND METHODS: Included in this study were all patients in whom a macular edema was diagnosed during an ophthalmological examination at the Barmherzigen Brüdern Hospital in Linz from November 2012 to August 2014 and who were treated as outpatients or day clinic patients with IVOM using anti-vascular endothelial growth factor (VEGF)...
November 4, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27803869/alcohol-consumption-and-dry-eye-syndrome-a-meta-analysis
#4
Yong-Sheng You, Nai-Bin Qu, Xiao-Ning Yu
AIM: To quantify the association between alcohol consumption and dry eye syndrome (DES) with Meta-analysis of published case-control and cross-sectional studies. METHODS: Three databases were screened for potentially eligible studies through Nov. 30, 2015, PubMed, Web of Science, and the Cochrane Library. Odds ratios (ORs) were pooled with 95% confidence intervals (CIs) to evaluate the relationship between alcohol consumption and DES risk. Subgroup analyses were performed according to diagnostic criteria, publication year, sample size, alcohol intake and adjusted factors...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27797641/effect-of-omega-3-fatty-acids-dietary-supplementation-on-ocular-surface-and-tear-film-in-diabetic-patients-with-dry-eye
#5
Constantine D Georgakopoulos, Olga E Makri, Dionisios Pagoulatos, Panagiotis Vasilakis, Politimi Peristeropoulou, Vasiliki Kouli, Maria I Eliopoulou, Caterina Psachoulia
OBJECTIVE: The objective of this study was to investigate the effect of dietary supplementation with omega-3 fatty acids on ocular surface and tear film in patients with type 2 diabetes suffering from dry eye. METHODS: Thirty-six patients suffering from type 2 diabetes and moderate to severe dry eye syndrome were included in the study. Patients were assigned to receive omega-3 long-chain polyunsaturated fatty acids for 3 months. Tear film break-up time test, Schirmer-I test, and conjunctival impression cytology analysis were performed on all patients at baseline and after 1 and 3 months...
October 31, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27703986/the-yin-and-yang-of-the-opioid-growth-regulatory-system-focus-on-diabetes-the-lorenz-e-zimmerman-tribute-lecture
#6
Joseph W Sassani, Patricia J Mc Laughlin, Ian S Zagon
The Opioid Growth Regulatory System consists of opioid growth factor (OGF), [Met(5)]-enkephalin, and its unique receptor (OGFr). OGF inhibits cell division when bound to OGFr. Conversely, blockade of the interaction of OGF and OGFr, using the potent, long-acting opioid receptor antagonist, naltrexone (NTX), results in increased DNA synthesis and cell division. The authors have demonstrated both in vitro and in vivo that the addition of exogenous OGF or an increase in available OGFr decreases corneal epithelial cell division and wound healing...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27566619/clinical-applications-of-dexamethasone-for-aged-eyes
#7
Beatriz Abadia, Pilar Calvo, Antonio Ferreras, Fran Bartol, Guayente Verdes, Luis Pablo
The risk of severe eye problems has been found to increase significantly with age, particularly between the fifth and sixth decades of life. Cataracts, dry eye, neovascular age-related macular degeneration, diabetic retinopathy and retinal vein occlusion (RVO) are very common and very different age-related ocular diseases that reduce the patient's quality of life. The rationale for using corticosteroids to treat anterior and posterior ocular segment diseases is driven by inflammation. Dexamethasone, one of the most powerful corticosteroids available, is widely used for topical or intravitreal administration...
September 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27489152/interleukin-1%C3%AE-and-tumour-necrosis-factor-%C3%AE-levels-in-conjunctiva-of-diabetic-patients-with-symptomatic-moderate-dry-eye-case-control-study
#8
Chen Zhang, Lei Xi, Shaozhen Zhao, Ruihua Wei, Yue Huang, Ruibo Yang, Long Su, Xun Liu
OBJECTIVES: To compare expression of interleukin (IL)-1β and tumour necrosis factor (TNF)-α in the conjunctiva of diabetic and non-diabetic patients with symptomatic moderate dry eye. SETTING AND PARTICIPANTS: Nineteen diabetic patients with dry eye, 15 non-diabetic patients with dry eye and 14 diabetic patients without dry eye were recruited. The relative expression of IL-1β and TNF-α in conjunctival impression cytology (CIC) specimens was evaluated using immunofluorescent staining and in conjunctival biopsy specimens using immunohistochemical staining...
2016: BMJ Open
https://www.readbyqxmd.com/read/27450739/thymosin-beta-4-a-potential-novel-therapy-for-neurotrophic-keratopathy-dry-eye-and-ocular-surface-diseases
#9
G Sosne, D Rimmer, H K Kleinman, G Ousler
Chronic ocular surface diseases such as dry eye, blepharitis, and neurotrophic keratopathies represent a significant and a growing therapeutic challenge. The basis of this expanding prevalence is multifactorial and may due to issues such as an aging population, an increasing use of video display terminals, and increases in frequency of refractive surgeries. The growing incidence of diseases such as diabetes may also be a contributing factor. Current treatments for ocular surface disease include artificial tears, lubricants, tear duct plugs, steroids, antibiotics, cyclosporine, scleral lenses, and serum tears...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/27439739/image-artefacts-in-swept-source-optical-coherence-tomography-angiography
#10
Khalil Ghasemi Falavarjani, Mayss Al-Sheikh, Handan Akil, Srinivas R Sadda
PURPOSE: To describe optical coherence tomography angiography (OCTA) image artefacts in eyes with and without ocular pathologies. METHODS: The OCTA images of healthy subjects and patients with age-related macular degeneration, diabetic retinopathy and retinal vascular occlusions were retrospectively reviewed. All OCTA images were obtained using a swept-source OCTA instrument (Triton, Topcon). The frequency of various image artefacts including segmentation, banding, motion, projection, masking, unmasking, doubling of the retinal vessels, blink, stretching, out-of-window and crisscross artefacts was assessed...
July 20, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27418872/comparison-of-dry-eye-parameters-between-diabetics-and-non-diabetics-in-district-of-kuantan-pahang
#11
Mohammed Aljarousha, Noor Ezailina Badarudin, Mohd Zulfaezal Che Azemin
INTRODUCTION: Diabetes may affect the human body's systems and organs, including the eye. Diabetic retinopathy is the 5th leading cause of blindness globally. Diabetic subjects demonstrated dry eye symptoms that were also supported by the low values of the clinical tests. PURPOSE: This study aimed to compare the dry eye symptoms and signs between diabetics and non-diabetics and tear functions between diabetic subjects with and without dry eye. METHODS: This retrospective study was based on the observation of 643 medical files...
May 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27263827/lacosamide-diminishes-dryness-induced-hyperexcitability-of-corneal-cold-sensitive-nerve-terminals
#12
Illés Kovács, Lóránt Dienes, Kristóf Perényi, Susana Quirce, Carolina Luna, Kamila Mizerska, M Carmen Acosta, Carlos Belmonte, Juana Gallar
Lacosamide is an anti-epileptic drug that is also used for the treatment of painful diabetic neuropathy acting through voltage-gated sodium channels. The aim of this work was to evaluate the effects of acute application of lacosamide on the electrical activity of corneal cold nerve terminals in lacrimo-deficient guinea pigs. Four weeks after unilateral surgical removal of the main lachrimal gland in guinea pigs, corneas were excised and superfused in vitro at 34°C for extracellular electrophysiological recording of nerve terminal impulse activity of cold thermosensitive nerve terminals...
September 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27257394/persistent-corneal-epithelial-defect-responding-to-rebamipide-ophthalmic-solution-in-a-patient-with-diabetes
#13
Yusuke Hayashi, Hiroshi Toshida, Yusuke Matsuzaki, Asaki Matsui, Toshihiko Ohta
OBJECTIVE: Rebamipide ophthalmic suspension was developed for the treatment of dry eyes and for other corneal diseases, promoting the secretion of both mucin in tear fluid and membrane-associated mucin, increasing the number of goblet cells, and restoring the barrier function of the corneal epithelium. We report a case of a persistent corneal epithelial defect in a patient with diabetes treated with topical application of rebamipide ophthalmic suspension. CASE PRESENTATION: A 73-year-old woman had a history of type 2 diabetes for 35 years and nonproliferative diabetic retinopathy for 23 years...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27213053/dry-eye-syndrome-in-patients-with-diabetes-mellitus-prevalence-etiology-and-clinical-characteristics
#14
REVIEW
Xinyuan Zhang, Lin Zhao, Shijing Deng, Xuguang Sun, Ningli Wang
There has been substantial progress in our understanding of the ocular surface system/lacrimal function unit in the past 15 years. Keratoconjunctivitis sicca, more commonly referred to as dry eye syndrome (DES), is the most frequently encountered condition and diabetes mellitus (DM) has been identified as one of the leading causes of DES. Poor glycemic control affects both the anterior and the posterior segments of the eye and increasing prevalence of diabetes-associated DES (DMDES) has been reported in recent years...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27159168/ocular-surface-characteristics-in-diabetic-children
#15
Murat Gunay, Gokhan Celik, Elvin Yildiz, Handan Bardak, Nermin Koc, Heves Kirmizibekmez, Betul Onal Gunay, Rahime Gul Yesiltepe Mutlu
PURPOSE: To compare tear film osmolarity (TFO) and other dry eye tests between diabetic children and normal healthy children. MATERIALS AND METHODS: Twenty-six diabetic children (Group 1) and 20 healthy children without any ocular and/or systemic disorder (Group 2) were enrolled in the study. Detailed ocular surface assessment including, ocular surface disease index (OSDI) questionnaire, TFO measurement (Tear Lab Osmolarity System, San Diago, CA, USA), corneal epithelial thickness (CET) measurement using the anterior segment optical coherence tomography (OCT) (RTVue CAM, Optovue Inc, CA, USA), tear film break-up time (TFBUT) test, Schirmer test, meibography, and conjunctival brush cytology were performed...
May 9, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27130673/dtb-select-5-may-2016
#16
(no author information available yet)
Hyperkalaemia with spironolactone ● Testosterone treatment in older men and sexual function ● OTC artificial tear drops for dry eye ● Decline in age-specific incidence of dementia ● Diabetes and blood pressure targets ● Zika virus and travel advice for pregnant women ● Minimising the risk of DKA with SGLT2 inhibitors ● NSAIDs for chronic low back pain ● Review of online point-of-care information.
May 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27121705/are-higher-blood-mercury-levels-associated-with-dry-eye-symptoms-in-adult-koreans-a-population-based-cross-sectional-study
#17
So-Hyang Chung, Jun-Pyo Myong
OBJECTIVES: The purpose of this study was to investigate whether blood mercury concentrations associated with the presence of dry eye symptoms in a nationally representative Korean population. METHODS: Population-based prospective cross-sectional study using the heavy metal data set of the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES). A total of 4761 adult Koreans were the eligible population in this study. Of the 7162 survey participants, 2401 were excluded because they were <19 years of age, there were missing data in the heavy metal data set, or they had diabetes, rheumatoid arthritis, thyroid disease, asthma, depression and/or under-the-eye surgery...
2016: BMJ Open
https://www.readbyqxmd.com/read/27051666/eclectic-ocular-comorbidities-and-systemic-diseases-with-eye-involvement-a-review
#18
REVIEW
María D Pinazo-Durán, Vicente Zanón-Moreno, José J García-Medina, J Fernando Arévalo, Roberto Gallego-Pinazo, Carlo Nucci
Coexistence of several ocular diseases is more frequent than suspected. In spite of the refractive errors, one or more of the following can be detected simultaneously: glaucoma, cataracts, uveitis, age-related macular degeneration, and dry eyes. In addition, as people age, ocular comorbidities are much more usually seen. Specific diseases are openly acknowledged to affect the eyes and vision, such as diabetes mellitus, hypertension blood pressure, arthritis, hyperthyroidism, neurodegenerative disorders, hematologic malignancies, and/or systemic infections...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27034823/a-controlled-study-on-the-correlation-between-tear-film-volume-and-tear-film-stability-in-diabetic-patients
#19
Iman M Eissa, Noha M Khalil, Heba A El-Gendy
Purpose. To assess the tear film quantity and correlate it with the quality and stability of the tear film in diabetics and compare them to age matched controls. Introduction. Diabetes affects tear film parameters in multiple ways. Poor metabolic control and neuropathy are postulated factors. To further understand how diabetes affects tear film parameters this study was conducted. Subjects and Methods. Tear meniscus height was measured by anterior segment OCT, along with tear thinning time, a subtype of noninvasive tear break-up time, and blinking rate per minute which were all recorded for 22 diabetic patients...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/26903719/prevalence-and-associated-factors-of-dry-eye-our-experience-in-patients-above-40-years-of-age-at-a-tertiary-care-center
#20
Suchi Shah, Harsha Jani
CONTEXT: Dry eye is a very common as well as under-diagnosed ocular disorder. It is not only troublesome in terms of its symptoms but also imposes a great financial burden. AIMS: To determine the prevalence of dry eye in ophthalmology out-patients at a Tertiary Care Hospital and its association with various clinico-epidemiological factors. SETTINGS AND DESIGN: A hospital-based study at a Tertiary Care Center was conducted including 400 out-patients of age 40 years and above...
September 2015: Oman Journal of Ophthalmology
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