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Dry eye and diabetes

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https://www.readbyqxmd.com/read/28087407/polymeric-micelles-for-ocular-drug-delivery-from-structural-frameworks-to-recent-preclinical-studies
#1
REVIEW
Abhirup Mandal, Rohit Bisht, Ilva D Rupenthal, Ashim K Mitra
Effective intraocular drug delivery poses a major challenge due to the presence of various elimination mechanisms and physiological barriers that result in low ocular bioavailability after topical application. Over the past decades, polymeric micelles have emerged as one of the most promising drug delivery platforms for the management of ocular diseases affecting the anterior (dry eye syndrome) and posterior (age-related macular degeneration, diabetic retinopathy and glaucoma) segments of the eye. Promising preclinical efficacy results from both in-vitro and in-vivo animal studies have led to their steady progression through clinical trials...
January 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28005448/tear-film-and-ocular-surface-evaluation-in-gestational-diabetes-mellitus
#2
S Kan, U Acar, M Kizilgul, E Beyazyildiz, A B Cankaya, M Apaydin, S Beysel, M Ozbek
BACKGROUND: Dry eye syndrome is one of the complaints of diabetic patients. The aim of the present study was to evaluate the tear functions in pregnant women with gestational diabetes mellitus (GDM) using tests: Schirmer, tear break-up time (TBUT), and tear film osmolarity (TFO) tests and the Ocular Surface Disease Index score (OSDI). METHODS: Pregnant women with GDM (Group 1, n=46) and healthy pregnant women (Group 2, n=36) were enrolled. Initially, all participants were asked to answer the OSDI and then they underwent a detailed ophthalmic examination including Schirmer, TBUT, and TFO tests...
December 22, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28003972/changes-of-meibomian-glands-in-patients-with-type-2-diabetes-mellitus
#3
Tao Yu, Wei-Yun Shi, Ai-Ping Song, Yang Gao, Guang-Fu Dang, Gang Ding
AIM: To investigate the morphological changes of meibomian glands in patients with type 2 diabetes mellitus (DM). METHODS: Of 118 eyes (118 patients) with type 2 DM (DM group) and 100 eyes of 100 control subjects (control group) were enrolled. After completing an ocular surface disease index (OSDI) questionnaire, the non-invasive tear film break-up time (NI-BUT) and the structure of the meibomian glands (MGs, meibography) were assessed by the Keratograph 5M system...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27974306/common-eye-diseases-in-older-adults-of-southern-germany-results-from-the-kora-age-study
#4
Peter Reitmeir, Birgit Linkohr, Margit Heier, Sophie Molnos, Ralf Strobl, Holger Schulz, Michaela Breier, Theresa Faus, Dorothea M Küster, Andrea Wulff, Harald Grallert, Eva Grill, Annette Peters, Jochen Graw
PURPOSE: a population-based study in the region of Augsburg (Germany, KORA) was used to identify the prevalence of eye diseases and their risk factors in a sample of aged individuals. METHODS: data originated from the KORA-Age study collected in 2012 and 822 participants (49.6% women, 50.4% men, aged 68-96 years) were asked standardised questions about eye diseases. Positive answers were validated and specified by treating ophthalmologists. Additional information came from laboratory data...
December 14, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27888572/adverse-effect-profile-of-topical-ocular-administration-of-fingolimod-for-treatment-of-dry-eye-disease
#5
Weibao Xiao, Li Sun, Nan Zhang, Wen Ye
Fingolimod is a promising prodrug in attenuating multiple sclerosis and prolonging survival of organ allograft, with many other protective effects. Its mechanism of action is related to the internalization of sphingosine 1-phosphate receptors (S1PRs). Our previous study indicated that fingolimod eyedrop was efficacious in inhibiting ocular inflammation in a dry eye disease (DED) model of Non-Obese Diabetic (NOD) mice. In the current study, we evaluated potential adverse effects of fingolimod eyedrop. Inbred 10-week-old BALB/C mice were randomly divided into four groups, fingolimod-treated groups at three different concentrations (0...
November 26, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27853013/ocular-manifestations-of-type-1-diabetes-mellitus-in-pediatric-population
#6
Handan Akil, Ayse Derya Buluş, Nesibe Andiran, Mehmet Numan Alp
CONTEXT: To evaluate the necessity of ocular screening in Type 1 diabetes mellitus (DM). AIMS: This study aims to investigate the diabetes-related ocular changes according to the glycosylated hemoglobin (HbA1c) level and duration of diabetes in children and compare the results with nondiabetic healthy children. SETTINGS AND DESIGN: Observational cross-sectional study designed by ophthalmology and pediatric endocrinology clinics. SUBJECTS AND METHODS: Forty-two children with Type 1 DM, 42 healthy gender- and age-matched children as controls were enrolled...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27815675/-what-can-anti-vegf-therapy-achieve-in-clinical-routine-effectiveness-of-anti-vegf-therapy-in-patients-with-macular-diseases-in-clinical-routine-on-1492-eyes-in-austria
#7
K Wiesinger, P Reinelt, A Ennemoser, M Edelmayr, U Schönherr
BACKGROUND: The aim of this user observational study was to illustrate the effectiveness of intravitreal operative medication administration (IVOM) in the clinical routine. DESIGN: A monocentric, single arm, prospective study. MATERIAL AND METHODS: Included in this study were all patients in whom a macular edema was diagnosed during an ophthalmological examination at the Barmherzigen Brüdern Hospital in Linz from November 2012 to August 2014 and who were treated as outpatients or day clinic patients with IVOM using anti-vascular endothelial growth factor (VEGF)...
November 4, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27803869/alcohol-consumption-and-dry-eye-syndrome-a-meta-analysis
#8
Yong-Sheng You, Nai-Bin Qu, Xiao-Ning Yu
AIM: To quantify the association between alcohol consumption and dry eye syndrome (DES) with Meta-analysis of published case-control and cross-sectional studies. METHODS: Three databases were screened for potentially eligible studies through Nov. 30, 2015, PubMed, Web of Science, and the Cochrane Library. Odds ratios (ORs) were pooled with 95% confidence intervals (CIs) to evaluate the relationship between alcohol consumption and DES risk. Subgroup analyses were performed according to diagnostic criteria, publication year, sample size, alcohol intake and adjusted factors...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27797641/effect-of-omega-3-fatty-acids-dietary-supplementation-on-ocular-surface-and-tear-film-in-diabetic-patients-with-dry-eye
#9
Constantine D Georgakopoulos, Olga E Makri, Dionisios Pagoulatos, Panagiotis Vasilakis, Politimi Peristeropoulou, Vasiliki Kouli, Maria I Eliopoulou, Caterina Psachoulia
OBJECTIVE: The objective of this study was to investigate the effect of dietary supplementation with omega-3 fatty acids on ocular surface and tear film in patients with type 2 diabetes suffering from dry eye. METHODS: Thirty-six patients suffering from type 2 diabetes and moderate to severe dry eye syndrome were included in the study. Patients were assigned to receive omega-3 long-chain polyunsaturated fatty acids for 3 months. Tear film break-up time test, Schirmer-I test, and conjunctival impression cytology analysis were performed on all patients at baseline and after 1 and 3 months...
October 31, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27703986/the-yin-and-yang-of-the-opioid-growth-regulatory-system-focus-on-diabetes-the-lorenz-e-zimmerman-tribute-lecture
#10
REVIEW
Joseph W Sassani, Patricia J Mc Laughlin, Ian S Zagon
The Opioid Growth Regulatory System consists of opioid growth factor (OGF), [Met(5)]-enkephalin, and its unique receptor (OGFr). OGF inhibits cell division when bound to OGFr. Conversely, blockade of the interaction of OGF and OGFr, using the potent, long-acting opioid receptor antagonist, naltrexone (NTX), results in increased DNA synthesis and cell division. The authors have demonstrated both in vitro and in vivo that the addition of exogenous OGF or an increase in available OGFr decreases corneal epithelial cell division and wound healing...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27566619/clinical-applications-of-dexamethasone-for-aged-eyes
#11
Beatriz Abadia, Pilar Calvo, Antonio Ferreras, Fran Bartol, Guayente Verdes, Luis Pablo
The risk of severe eye problems has been found to increase significantly with age, particularly between the fifth and sixth decades of life. Cataracts, dry eye, neovascular age-related macular degeneration, diabetic retinopathy and retinal vein occlusion (RVO) are very common and very different age-related ocular diseases that reduce the patient's quality of life. The rationale for using corticosteroids to treat anterior and posterior ocular segment diseases is driven by inflammation. Dexamethasone, one of the most powerful corticosteroids available, is widely used for topical or intravitreal administration...
September 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27489152/interleukin-1%C3%AE-and-tumour-necrosis-factor-%C3%AE-levels-in-conjunctiva-of-diabetic-patients-with-symptomatic-moderate-dry-eye-case-control-study
#12
Chen Zhang, Lei Xi, Shaozhen Zhao, Ruihua Wei, Yue Huang, Ruibo Yang, Long Su, Xun Liu
OBJECTIVES: To compare expression of interleukin (IL)-1β and tumour necrosis factor (TNF)-α in the conjunctiva of diabetic and non-diabetic patients with symptomatic moderate dry eye. SETTING AND PARTICIPANTS: Nineteen diabetic patients with dry eye, 15 non-diabetic patients with dry eye and 14 diabetic patients without dry eye were recruited. The relative expression of IL-1β and TNF-α in conjunctival impression cytology (CIC) specimens was evaluated using immunofluorescent staining and in conjunctival biopsy specimens using immunohistochemical staining...
2016: BMJ Open
https://www.readbyqxmd.com/read/27450739/thymosin-beta-4-a-potential-novel-therapy-for-neurotrophic-keratopathy-dry-eye-and-ocular-surface-diseases
#13
G Sosne, D Rimmer, H K Kleinman, G Ousler
Chronic ocular surface diseases such as dry eye, blepharitis, and neurotrophic keratopathies represent a significant and a growing therapeutic challenge. The basis of this expanding prevalence is multifactorial and may due to issues such as an aging population, an increasing use of video display terminals, and increases in frequency of refractive surgeries. The growing incidence of diseases such as diabetes may also be a contributing factor. Current treatments for ocular surface disease include artificial tears, lubricants, tear duct plugs, steroids, antibiotics, cyclosporine, scleral lenses, and serum tears...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/27439739/image-artefacts-in-swept-source-optical-coherence-tomography-angiography
#14
Khalil Ghasemi Falavarjani, Mayss Al-Sheikh, Handan Akil, Srinivas R Sadda
PURPOSE: To describe optical coherence tomography angiography (OCTA) image artefacts in eyes with and without ocular pathologies. METHODS: The OCTA images of healthy subjects and patients with age-related macular degeneration, diabetic retinopathy and retinal vascular occlusions were retrospectively reviewed. All OCTA images were obtained using a swept-source OCTA instrument (Triton, Topcon). The frequency of various image artefacts including segmentation, banding, motion, projection, masking, unmasking, doubling of the retinal vessels, blink, stretching, out-of-window and crisscross artefacts was assessed...
July 20, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27418872/comparison-of-dry-eye-parameters-between-diabetics-and-non-diabetics-in-district-of-kuantan-pahang
#15
Mohammed Aljarousha, Noor Ezailina Badarudin, Mohd Zulfaezal Che Azemin
INTRODUCTION: Diabetes may affect the human body's systems and organs, including the eye. Diabetic retinopathy is the 5th leading cause of blindness globally. Diabetic subjects demonstrated dry eye symptoms that were also supported by the low values of the clinical tests. PURPOSE: This study aimed to compare the dry eye symptoms and signs between diabetics and non-diabetics and tear functions between diabetic subjects with and without dry eye. METHODS: This retrospective study was based on the observation of 643 medical files...
May 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27263827/lacosamide-diminishes-dryness-induced-hyperexcitability-of-corneal-cold-sensitive-nerve-terminals
#16
Illés Kovács, Lóránt Dienes, Kristóf Perényi, Susana Quirce, Carolina Luna, Kamila Mizerska, M Carmen Acosta, Carlos Belmonte, Juana Gallar
Lacosamide is an anti-epileptic drug that is also used for the treatment of painful diabetic neuropathy acting through voltage-gated sodium channels. The aim of this work was to evaluate the effects of acute application of lacosamide on the electrical activity of corneal cold nerve terminals in lacrimo-deficient guinea pigs. Four weeks after unilateral surgical removal of the main lachrimal gland in guinea pigs, corneas were excised and superfused in vitro at 34°C for extracellular electrophysiological recording of nerve terminal impulse activity of cold thermosensitive nerve terminals...
September 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27257394/persistent-corneal-epithelial-defect-responding-to-rebamipide-ophthalmic-solution-in-a-patient-with-diabetes
#17
Yusuke Hayashi, Hiroshi Toshida, Yusuke Matsuzaki, Asaki Matsui, Toshihiko Ohta
OBJECTIVE: Rebamipide ophthalmic suspension was developed for the treatment of dry eyes and for other corneal diseases, promoting the secretion of both mucin in tear fluid and membrane-associated mucin, increasing the number of goblet cells, and restoring the barrier function of the corneal epithelium. We report a case of a persistent corneal epithelial defect in a patient with diabetes treated with topical application of rebamipide ophthalmic suspension. CASE PRESENTATION: A 73-year-old woman had a history of type 2 diabetes for 35 years and nonproliferative diabetic retinopathy for 23 years...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27213053/dry-eye-syndrome-in-patients-with-diabetes-mellitus-prevalence-etiology-and-clinical-characteristics
#18
REVIEW
Xinyuan Zhang, Lin Zhao, Shijing Deng, Xuguang Sun, Ningli Wang
There has been substantial progress in our understanding of the ocular surface system/lacrimal function unit in the past 15 years. Keratoconjunctivitis sicca, more commonly referred to as dry eye syndrome (DES), is the most frequently encountered condition and diabetes mellitus (DM) has been identified as one of the leading causes of DES. Poor glycemic control affects both the anterior and the posterior segments of the eye and increasing prevalence of diabetes-associated DES (DMDES) has been reported in recent years...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27159168/ocular-surface-characteristics-in-diabetic-children
#19
Murat Gunay, Gokhan Celik, Elvin Yildiz, Handan Bardak, Nermin Koc, Heves Kirmizibekmez, Betul Onal Gunay, Rahime Gul Yesiltepe Mutlu
PURPOSE: To compare tear film osmolarity (TFO) and other dry eye tests between diabetic children and normal healthy children. MATERIALS AND METHODS: Twenty-six diabetic children (Group 1) and 20 healthy children without any ocular and/or systemic disorder (Group 2) were enrolled in the study. Detailed ocular surface assessment including, ocular surface disease index (OSDI) questionnaire, TFO measurement (Tear Lab Osmolarity System, San Diago, CA, USA), corneal epithelial thickness (CET) measurement using the anterior segment optical coherence tomography (OCT) (RTVue CAM, Optovue Inc, CA, USA), tear film break-up time (TFBUT) test, Schirmer test, meibography, and conjunctival brush cytology were performed...
December 2016: Current Eye Research
https://www.readbyqxmd.com/read/27130673/dtb-select-5-may-2016
#20
(no author information available yet)
Hyperkalaemia with spironolactone ● Testosterone treatment in older men and sexual function ● OTC artificial tear drops for dry eye ● Decline in age-specific incidence of dementia ● Diabetes and blood pressure targets ● Zika virus and travel advice for pregnant women ● Minimising the risk of DKA with SGLT2 inhibitors ● NSAIDs for chronic low back pain ● Review of online point-of-care information.
May 2016: Drug and Therapeutics Bulletin
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