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https://www.readbyqxmd.com/read/29232321/elevated-interleukin-1%C3%AE-and-interleukin-6-levels-in-the-serum-of-children-with-hyperuricemia
#1
Yazhen Di, Jiapei Wang, Yuanling Chen, Nan Sun, Ling Wu, Xiahua Dai, Mengjiao Shen, Qianqian Ying, Shiwei Fu
PURPOSES: The aim of this study was to investigate the serum levels and clinical significance of interleukin 1β (IL-1β) and IL-6 in children with hyperuricemia (HUA). METHODS: We included 71 children with HUA and 71 children with no HUA as control subjects. Children with HUA were divided into groups I and II according to whether they had a history of acute gout-like attacks (including sudden monoarthritis of rapid onset with intense pain and swelling). Group I was examined twice (A, in the acute phase; B, in the remission phase)...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29217806/synovial-arteriovenous-malformation-masquerading-as-arthritis
#2
Pooja Prakash Mallya, Anand Prahalad Rao
BACKGROUND: Synovial arteriovenous malformation is rare. CASE CHARACTERISTICS: We present three children with recurrent monoarthritis secondary to synovial arteriovenous malformation. OUTCOME: Two children underwent excision of arteriovenous malformation. Another child had diffuse arteriovenous malformation, which was inoperable. MESSAGE: Synovial arteriovenous malformations should be considered in the differential diagnosis of monoarthritis, especially of the knee...
November 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29201195/anti-nociceptive-effect-of-dexmedetomidine-in-a-rat-model-of-monoarthritis-via-suppression-of-the-tlr4-nf-%C3%AE%C2%BAb-p65-pathway
#3
Dong Ji, Yalan Zhou, Shuangshuang Li, Dai Li, Hui Chen, Yuanchang Xiong, Yuqiu Zhang, Hua Xu
As a therapeutic target for neuropathic pain, the anti-nociceptive effects of α 2-adrenoceptors (α2AR) have attracted attention. Dexmedetomidine (DEX), a potent and highly selective α2AR agonist, has exhibited significant analgesic effects in neuropathic pain, but the underlying mechanism has remained elusive. The present study investigated the effect of DEX on Toll-like receptor (TLR)4 and nuclear factor (NF)-κB p65 expression, as well as the production of pro-inflammatory cytokines. The rat monoarthritis (MA) model was induced by intra-articular injection of complete Freund's adjuvant (CFA) at the ankle joint...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29171630/-elbow-monoarthritis-and-bone-infarction-as-a-form-of-presentation-of-b-cell-lymphoma-case-report
#4
Paulina Díaz Asencio, Oscar Contreras Olea, Josefina Durán Santa Cruz
No abstract text is available yet for this article.
June 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29149964/chikungunya-infection-in-solid-organ-transplant-recipients
#5
E S Girão, B G Rodrigues Dos Santos, E S do Amaral, P E G Costa, K B Pereira, A H de Araujo Filho, E B Hyppolito, M U Mota, L C B F Marques, C M Costa de Oliveira, S L da Silva, J H P Garcia, P F C B C Fernandes
BACKGROUND: Chikungunya virus (CHIKV) is an emerging mosquito-borne disease that causes acute febrile polyarthralgia and arthritis. CHIKV has spread rapidly to the Americas and, in Brazil, autochthonous cases are increasingly been reported. Solid organ transplant (SOT) recipients who travel to or live in CHIKV endemic areas are under high risk of acquiring the disease. Few data exist regarding the clinical characteristics of CHIKV infections in this population. We report the first case series of CHIKV infection in SOT recipients...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29120570/early-referral-improves-long-term-outcomes-in-rheumatoid-arthritis
#6
Jobie Evans, Andra Negoescu
Rheumatoid arthritis (RA) is a common, chronic systemic inflammatory disease of unclear aetiology leading to synovial hypertrophy and joint inflammation. It typically presents with symmetrical polyarthritis of small joints of the hands or feet, but can also involve larger joints, and have associated extra-articular manifestations. Diagnosis is based on duration of symptoms, joint distribution, level of inflammatory markers and autoantibodies i.e. rheumatoid factor(RhF) and anty-cyclic citrullinated peptide (CCP) antibodies...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29032304/heterocyclic-homoprostanoid-derivative-attenuates-monoarthritis-in-rats-an-in-vitro-and-in-vivo-preclinical-paradigm
#7
Jayesh Mudgal, S A Manohara Reddy, Geetha Mathew, Anoop Kishore, C Mallikarjuna Rao, Gopalan K Nampurath
From our lab, among the nineteen heterocyclic homoprostanoids (HHPs), three derivatives (compounds 3, 3b and 3c) exerted antioxidant and anti-inflammatory activity. Present study is an extension of the earlier work, and, is designed to establish their therapeutic potential in monoarthritis in rats. In addition, their possible mechanism of action would be investigated. A battery of in vitro tests such as lipopolysaccharide (LPS)-induced nitrite (NO)/reactive oxygen species (ROS) and NO/interleukin (IL)-6 generation in murine macrophages and whole blood (WhB), respectively were conducted...
October 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28980897/comparison-of-patients-with-familial-mediterranean-fever-accompanied-with-sacroiliitis-and-patients-with-juvenile-spondyloarthropathy
#8
Hafize Emine Sönmez, Ezgi Deniz Batu, Selcan Demir, Yelda Bilginer, Seza Özen
OBJECTIVES: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease manifesting with self-limited recurrent febrile attacks and polyserositis. Acute recurrent monoarthritis is the most common form of musculoskeletal involvement in FMF; however, up to 5% of FMF patients may develop chronic joint diseases including sacroiliitis. It is difficult to distinguish whether sacroiliitis is a musculoskeletal finding of FMF or whether this is the coexistence of two diseases, FMF and SpA...
September 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28926460/peripheral-bacterial-septic-arthritis-review-of-diagnosis-and-management
#9
Ahmed S Hassan, Allison Rao, Augustine M Manadan, Joel A Block
Septic arthritis refers to an infection in a joint due to a bacterial, mycobacterial, or fungal cause. Joint infections are a serious cause of morbidity and mortality and constitute a true musculoskeletal emergency. The estimated incidence of septic arthritis in the general population is between 2 and 6 cases per 100,000 people per year. The most common presentation is an acute monoarthritis. Identification of organisms in the synovial fluid is the criterion standard for diagnosis. Synovial fluid aspiration should be performed prior to initiating antibiotics...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28917998/clinical-characteristics-and-outcomes-in-polyarticular-septic-arthritis
#10
Sarah B Lieber, Mary Louise Fowler, Clara Zhu, Andrew Moore, Robert H Shmerling, Ziv Paz
OBJECTIVES: Septic polyarthritis is rarer than septic monoarthritis, but associated with higher mortality. Septic polyarthritis may be difficult to distinguish clinically from noninfectious inflammatory arthritis. We describe one of the largest samples of septic polyarthritis with the aim of distinguishing septic monoarthritis from polyarthritis. METHODS: We conducted a retrospective study of adults admitted to tertiary care with septic monoarthritis and polyarthritis...
September 14, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28844395/-a-case-of-gonococcal-arthritis-diagnostic-difficulties-and-usefulness-of-synovial-fluid-pcr
#11
N Rouanes, R Sanchez, C Cazanave
INTRODUCTION: The incidence of Neisseria gonorrhoeae septic arthritis remains low in the general population. Its clinical and microbiological diagnostic remains difficult. CASE REPORT: We report a 44-year-old man who presented with a monoarthritis of the right ankle. The diagnosis of gonoccocal septic arthritis was obtained by PCR from the joint fluid. Treatment with ceftriaxone was effective. CONCLUSION: In patients with high risk of N. gonorrhoeae infection, PCR for detection of gonorrhea in synovial fluid could potentially facilitate the diagnostic of gonococcal septic arthritis...
August 24, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28791458/-a%C3%A2-special-case-of-monoarthritis-of-the-elbow
#12
M Gautschi, K Strobel, R Schöniger, D Pfeiffer, L Schmid
No abstract text is available yet for this article.
September 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28777897/joint-distribution-and-2-year-outcome-in-347-patients-with-monoarthritis-of-less-than-16-weeks-duration
#13
Ellen Sauar Norli, Gina Hetland Brinkmann, Tore Kristian Kvien, Olav Bjørneboe, Anne Julsrud Haugen, Halvor Nygaard, Cathrine Thunem, Elisabeth Lie, Maria Dahl Mjaavatten
OBJECTIVE: To study the joint distribution and 2-year outcome of patients with recent-onset monoarthritis. METHODS: Adult patients with clinically apparent monoarthritis of ≤16 weeks' duration were included in a multi-center 2-year longitudinal study. Clinical characteristics, joint distribution, development of chronic inflammatory rheumatic disease (CIRD), as well as classification according to the 2010 ACR/EULAR classification criteria for rheumatoid arthritis (2010 RA criteria) were studied...
August 4, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28754137/tuberculous-monoarthritis-of-the-wrist-in-a-patient-with-systemic-lupus-erythematosus-a-case-report
#14
W A N V Luke, M P M L Gunathilake, Duminda Munidasa, Dilshan Munidasa, S T De Silva
BACKGROUND: Unusual forms of tuberculosis are common among immune-suppressed patients, leading to challenges in diagnosis and management. We present a Sri Lankan patient with systemic lupus erythematosis, investigated for chronic wrist pain with low inflammatory markers and without systemic symptoms, who was subsequently diagnosed to have tuberculosis of the joint. CASE PRESENTATION: A 31-year-old woman with systemic lupus erythematosis in remission was evaluated for chronic left wrist pain without significant examination findings on presentation...
July 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28721093/gout-mimicking-spondyloarthritis-case-report-and-literature-review
#15
Wenji Chen, Yanyan Wang, Yan Li, Zheng Zhao, Lixia Feng, Jian Zhu, Jianglin Zhang, Feng Huang
Gout is clinically characterized by episodes of monoarthritis, which not only typically affects the peripheral joints but also occasionally affect the axial joint, such as the sacroiliac joint (SIJ), and often mimics spondyloarthritis (SpA). Two cases of gout mimicking SpA are presented in the current paper. One patient was a 32-year-old man with a history of asymmetrical oligoarthritis of ankle and metatarsophalangeal joints (MTPJ). He had left gluteal pain for 2 weeks. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed the bone erosion of the left SIJ...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28685013/arthroscopic-approach-for-treating-a-pigmented-villonodular-sinovitis-of-tmj-a-case-report
#16
Maria Roman-Ramos, Paolo Cariati, Almudena Cabello-Serrano, Miguel Garcia-Martin, Blas Garcia-Medina
The present report describes the case of a 29-year-old man referred to our service for TMJ pain and progressive reduction of the mouth opening. Differential diagnostics included rheumatologic diseases, monoarthritis and intraarticular lumps. In this line, a face CT scan and a MRI of TMJ were carried out in order to ensure a proper diagnosis. These tests showed a solid lesion into the joint cavity. In view of that, we decided to perform a diagnostic and therapeutic arthroscopy of TMJ. Histopathological studies confirmed the diagnosis of pigmented villonodular synovitis...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28587132/anti-inflammatory-activity-of-a-polymeric-proanthocyanidin-from-serjania-schiedeana
#17
David Osvaldo Salinas-Sánchez, Enrique Jiménez-Ferrer, Veronica Sánchez-Sánchez, Alejandro Zamilpa, Manasés González-Cortazar, Jaime Tortoriello, Maribel Herrera-Ruiz
The ethyl acetate extract (SsAcOEt) from Serjania schiedeana, select fractions (F-6, F-12, F-13, F-14), and one isolated compound, were evaluated in 12-O-tetradecanoylphorbol 13-acetate (TPA) ear edema and kaolin/carrageenan (KC)-induced monoarthritis assays. SsEtOAc induced edema inhibition of 90% (2.0 mg/ear), fractions showed activity within a range of 67-89%. Due to the fact F-14 showed the highest effect, it was separated, yielding a proanthocyanidin-type called epicatechin-(4β → 8)-epicatechin-(4β → 8, 2β → O → 7) epicatechin (ETP)...
May 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28572233/lesson-of-the-month-1-septic-arthritis-with-normal-acute-phase-reactants-and-white-cell-count-in-a-patient-receiving-tocilizumab
#18
Richard Conway, Carl Orr, Geraldine M McCarthy
Septic arthritis represents 8-27% of cases of monoarthritis presenting to the emergency department. Tocilizumab is an interleukin-6 blocking monoclonal antibody with the mechanistic potential to interfere with the body's normal inflammatory response to an infectious insult. We present a case of septic arthritis with a normal white cell count, C-reactive protein, erythrocyte sedimentation rate and fibrinogen in a patient treated with tocilizumab.
June 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28553223/chronic-monoarthritis-pain-accelerates-the-processes-of-cognitive-impairment-and-increases-the-nmdar-subunits-nr2b-in-ca3-of-hippocampus-from-5-month-old-transgenic-app-ps1-mice
#19
Wei-Yi Gong, Rong Wang, Yuan Liu, He Jin, Zhi-Wei Zhao, Yu-Lan Wang, Hong-Yan Li, Xu Zhang, Jia-Xiang Ni
Many factors impact cognitive impairment; however, the effects of chronic pain and the mechanisms underlying these effects on cognitive impairment are currently unknown. Here we tested the hypothesis that chronic pain accelerates the transition from normal cognition to mild cognitive impairment (MCI) in 5-month-old transgenic APP/PS1 mice, an animal model of Alzheimer's disease (AD), and that neurotoxicity induced by N-methyl-D-aspartic acid receptor (NMDAR) subunits may be involved in this process. Chronic monoarthritis pain was induced in transgenic APP/PS1 mice and 5-month-old wild-type (WT) mice by intra- and pre-articular injections of Freund's complete adjuvant (FCA) into one knee joint...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28550532/drug-induced-hsp90-inhibition-alleviates-pain-in-monoarthritic-rats-and-alters-the-expression-of-new-putative-pain-players-at-the-drg
#20
Diana Sofia Marques Nascimento, Catarina Soares Potes, Miguel Luz Soares, António Carlos Ferreira, Marzia Malcangio, José Manuel Castro-Lopes, Fani Lourença Moreira Neto
Purinergic receptors (P2XRs) have been widely associated with pain states mostly due to their involvement in neuron-glia communication. Interestingly, we have previously shown that satellite glial cells (SGC), surrounding dorsal root ganglia (DRG) neurons, become activated and proliferate during monoarthritis (MA) in the rat. Here, we demonstrate that P2X7R expression increases in ipsilateral DRG after 1 week of disease, while P2X3R immunoreactivity decreases. We have also reported a significant induction of the activating transcriptional factor 3 (ATF3) in MA...
May 26, 2017: Molecular Neurobiology
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