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https://www.readbyqxmd.com/read/28431109/performance-of-the-2015-acr-eular-classification-criteria-for-gout-in-a-primary-care-population-presenting-with-monoarthritis
#1
Hein J E M Janssens, Jaap Fransen, Matthijs Janssen, Tuhina Neogi, H Ralph Schumacher, Tim L Jansen, Nicola Dalbeth, William J Taylor
Objective.: To test the performance of the 2015 ACR-EULAR gout classification criteria against presence of SF MSU crystals in a primary healthcare population. Methods.: The criteria were applied to an existing dataset of consecutive patients with monoarthritis presenting to Dutch family physicians; all patients underwent microscopic SF analysis by design. The data had been prospectively collected to develop a diagnostic decision rule for gout in 2010. Diagnostic performance was assessed by calculating area under the receiver operating characteristic curve, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and constructing calibration plots for the full version of the criteria (including SF analysis results of all patients) and the clinical-only version (not including SF analysis results)...
April 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#2
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28321113/acid-sensing-ion-channel-1a-in-the-amygdala-is-involved-in-pain-and-anxiety-related-behaviours-associated-with-arthritis
#3
Youssef Aissouni, Abderrahim El Guerrab, Al Mahdy Hamieh, Jérémy Ferrier, Maryse Chalus, Diane Lemaire, Stéphanie Grégoire, Monique Etienne, Alain Eschalier, Denis Ardid, Eric Lingueglia, Fabien Marchand
Chronic pain is associated with anxiety and depression episodes. The amygdala plays a key role in the relationship between emotional responses and chronic pain. Here, we investigated the role of Acid-Sensing Ion Channels 1a within the basolateral amygdala (BLA), in pain and associated anxiety in a rat model of monoarthritis (MoAr). Administration within the BLA of PcTx1 or mambalgin-1, two specific inhibitors of ASIC1a-containing channels significantly inhibited pain and anxiety-related behaviours in MoAr rats...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28255335/the-clinical-characteristics-of-sarcoid-arthropathy-based-on-a-prospective-cohort-study
#4
Senol Kobak, Fidan Sever, Ozan Usluer, Tuncay Goksel, Mehmet Orman
BACKGROUND: Sarcoidosis is known as a Th1-mediated disease, which can mimic many primary rheumatologic diseases or sometimes co-exist with them. Clinical characteristics of sarcoid arthropathy are not well described and the studies reported in the literature so far are mostly based on data from referrals. The aim of this study was to evaluate the incidence and clinical characteristics of sarcoid arthropathy. METHODS: All our patients were prospectively evaluated in our rheumatology outpatient center from 2011 to 2015...
December 2016: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28173831/immunoselected-stro-3-mesenchymal-precursor-cells-reduce-inflammation-and-improve-clinical-outcomes-in-a-large-animal-model-of-monoarthritis
#5
Anwar Abdalmula, Laura M Dooley, Claire Kaufman, Elizabeth A Washington, Jacqueline V House, Barbara A Blacklaws, Peter Ghosh, Silviu Itescu, Simon R Bailey, Wayne G Kimpton
BACKGROUND: The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine production in an ovine model of monoarthritis. METHODS: Monoarthritis was established in 16 adult merino sheep by administration of bovine type II collagen into the left hock joint following initial sensitization to this antigen. After 24 h, sheep were administered either 150 million allogeneic ovine MPCs (n = 8) or saline (n = 8) intravenously (IV)...
February 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28086918/atypical-monoarthritis-presentation-in-children-with-oligoarticular-juvenile-idiopathic-arthritis-a-case-series
#6
Natasha Lepore, Megan Cashin, Debra Bartley, Daniela Simona Ardelean
BACKGROUND: Oligoarticular juvenile idiopathic arthritis (oligoJIA), the most common chronic inflammatory arthritis of childhood, usually involves the knees and ankles. Severe oligoJIA monoarthritis presenting in a joint other than knees and ankles, is rare. FINDINGS: We report four children who presented with severe isolated arthritis of the hip, wrist or elbow and were diagnosed with oligoJIA. All four were girls with a median age of 11.5 years. Those with hip arthritis also met the classification criteria for juvenile-onset spondylarthopathy...
January 13, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27933357/bilateral-increases-in-erk-activation-at-the-spinomedullary-junction-region-by-acute-masseter-muscle-injury-during-temporomandibular-joint-inflammation-in-the-rats
#7
Masayuki Kurose, Hiroki Imbe, Yosuke Nakatani, Mana Hasegawa, Noritaka Fujii, Ritsuo Takagi, Kensuke Yamamura, Emiko Senba, Keiichiro Okamoto
We determined the role of persistent monoarthritis of temporomandibular joint region (TMJ) on bilateral masseter muscle (MM) nociception in male rats using orofacial nocifensive behaviors, phosphorylated extracellular signal-regulated kinase and Fos induction at the trigeminal subnucleus caudalis/upper cervical spinal cord (Vc/C2) region in response to formalin injection to the MM region. TMJ inflammation was induced by local injection of CFA into the left TMJ region. Orofacial nocifensive behaviors evoked by formalin injection ipsilateral or contralateral to the TMJ inflammation appeared to be increased at 1-14 days or at 1, 10 and 14 days after induction of TMJ inflammation, respectively, while increases in behavioral duration were seen mainly in the late phase rather than the early phase...
December 8, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27929277/acute-monoarthritis-diagnosis-in-adults
#8
Jonathan A Becker, Jennifer P Daily, Katherine M Pohlgeers
Acute monoarthritis can be the initial manifestation of many joint disorders. The most common diagnoses in the primary care setting are osteoarthritis, gout, and trauma. It is important to understand the prevalence of specific etiologies and to use the appropriate diagnostic modalities. A delay in diagnosis and treatment, particularly in septic arthritis, can have catastrophic results including sepsis, bacteremia, joint destruction, or death. The history and physical examination can help guide the use of laboratory and imaging studies...
November 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27917633/-differential-diagnosis-of-monoarthritis
#9
Kateřina Zegzulková, Šárka Forejtová
Making the diagnosis of monoarthritis can be quite difficult, because in contrast with polyarthritis just a few clinical data is available and wide diagnostic spectrum is present.The diagnosis of inflammatory rheumatic disease is usually in responsibility of a rheumatologist, but we know from experience that is necessary to carry out the basal differential diagnostic assessment as soon as possible to begin the optimal therapy. General practitioners and orthopaedists are usually first to face this problem.Monoarthritis can be divided into non-inflammatory arthritis where activated osteoarthritis and trauma belongs and inflammatory arthritis, which include gouty arthritis, chondrocalcinosis, infectious arthritis, juvenile idiopathic arthritis, spondylitis, incipient rheumatoid arthritis and many others...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27902172/is-it-easy-to-clinically-distinguish-inflammatory-arthritis-of-bacterial-origin-from-monoarthritis-attacks-of-gout-disease
#10
O Şahap Atik, Yılmaz Ergişi, Tacettin Ayanoğlu, Mehmet Ali Tokgöz, Erdem Aras Sezgin, Pınar Uyar Göçün
Acute monoarthritis is a common situation in orthopedic emergency where the patient presents with typical inflamed joint. It is hard to clinically distinguish inflammatory arthritis of bacterial origin from monoarthritis attacks of gout disease. If these two situations, which are the most common causes of acute monoarthritis, are misdiagnosed, outcomes might be catastrophic and costly. Synovial fluid analysis is the most reliable method for confirming the diagnosis although it might not always lead to definitive diagnosis...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27847461/enhanced-gamma-oscillatory-activity-in-rats-with-chronic-inflammatory-pain
#11
Jing Wang, Jing Wang, Guo-Gang Xing, Xiaoli Li, You Wan
It has been reported that oscillatory gamma activity participates in brief acute pain and tonic ongoing pain. It is of great interest to determine whether the gamma activity is involved in chronic pain since chronic pain is a more severe pathological condition characterized by pain persistency. To investigate the oscillatory gamma activity in chronic pain, in the present study, we recorded spontaneous electrocorticogram (ECoG) signals during chronic pain development in rats with chronic inflammatory pain induced by monoarthritis...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27736709/pancreatic-disease-panniculitis-polyarthrtitis-syndrome-successfully-treated-with-total-pancreatectomy-case-report-and-literature-review
#12
Valentina Ferri, Benedetto Ielpo, Hipolito Duran, Eduardo Diaz, Isabel Fabra, Riccardo Caruso, Luisi Malave, Carlos Plaza, Silvia Rodriguez, Lina Garcia, Virginia Perez, Yolanda Quijano, Emilio Vicente
INTRODUCTION: Pancreatic disease can be complicated by extrabdominal manifestations such as panniculitis and polyarthritis. The symptomatic triad comprising pancreatic disease, panniculitis and polyarthritis is also known as PPP syndrome and is characterized by severe chronic sequels and high mortality rate. We describe a case of PPP syndrome successfully treated with spleen preserving total pancreatectomy; in addition we performed a literature review. PRESENTATION OF CASE: A 67 years old male presented panniculitis and polyarthritis without clinical abdominal symptoms...
September 28, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27629113/characterization-of-chronic-arthritis-in-a-multicenter-study-of-852-childhood-onset-systemic-lupus-erythematosus-patients
#13
Ana Paula Sakamoto, Clovis Artur Silva, Mariana Paes Leme Ferriani, Rosa Maria Rodrigues Pereira, Eloisa Bonfá, Claudia Saad-Magalhães, Eunice Okuda, Simone Appenzeller, Francisco Hugo Gomes, Ana Luiza Garcia Cunha, Mirna Henriques Tomich Salume, Daniela Petry Piotto, Maria Teresa Terreri
Chronic arthritis (CA) is an unusual condition in childhood-onset systemic lupus erythematosus (cSLE) and data in children is very limited. The aim of the study is to assess CA in a large population of cSLE patients, in a multicenter cross-sectional study including 852 cSLE patients followed in ten Pediatric Rheumatology referral services in state of São Paulo, Brazil. CA was observed in 32/852 (3.7 %) cSLE patients mostly in hands and ankles. Chronic monoarthritis was diagnosed in four cSLE patients, oligoarthritis in nine and polyarthritis in 19...
December 2016: Rheumatology International
https://www.readbyqxmd.com/read/27584936/nociception-contributes-to-the-formation-of-myogenic-contracture-in-the-early-phase-of-adjuvant-induced-arthritis-in-a-rat-knee
#14
Akinori Kaneguchi, Junya Ozawa, Hideki Moriyama, Kaoru Yamaoka
It is unknown how joint contracture is generated in inflamed joints. This study aimed to clarify the role of nociception on the formation of joint contracture secondary to arthritis. Monoarthritis was induced by intra-articular injections of complete Freund's adjuvant (CFA) into rat knees. On day 5 after CFA injection, the passive extension range of motion (ROM) of knee joints were measured, both before and after myotomy of knee flexors, to evaluate the extent of muscular contribution to CFA-induced joint contracture...
September 1, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27574462/the-effect-of-intra-articular-vanilloid-receptor-agonists-on-pain-behavior-measures-in-a-murine-model-of-acute-monoarthritis
#15
Mishal Abdullah, Maren L Mahowald, Sandra P Frizelle, Christopher W Dorman, Sonia C Funkenbusch, Hollis E Krug
Arthritis is the most common cause of disability in the US, and the primary manifestation of arthritis is joint pain that leads to progressive physical limitation, disability, morbidity, and increased health care utilization. Capsaicin (CAP) is a vanilloid agonist that causes substance P depletion by interacting with vanilloid receptor transient receptor potential V1 on small unmyelinated C fibers. It has been used topically for analgesia in osteoarthritis with variable success. Resiniferatoxin (RTX) is an ultra potent CAP analog...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27542339/inhibition-of-hcn-channel-activity-in-the-thalamus-attenuates-chronic-pain-in-rats
#16
Weihua Ding, Zerong You, Shiqian Shen, Lucy Chen, Shengmei Zhu, Jianren Mao
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability in both peripheral and central nerve systems. Emerging evidence indicates that HCN channels are involved in the development and maintenance of chronic pain. However, the impact of HCN channel activity in the thalamus on chronic pain has not been examined. In this report, we evaluated the effect on nociceptive behaviors after infusion of a HCN channel blocker ZD7288 into the ventral posterolateral (VPL) nucleus of the thalamus in rats with neuropathic pain or monoarthritis...
September 19, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27512295/pegylated-interferon-monotherapy-for-hepatitis-c-virus-infection-in-patients-on-hemodialysis-a-single-center-study
#17
S K Agarwal, D Bhowmik, S Mahajan, S Bagchi
There is no published study from India on hepatitis C virus (HCV) treatment in dialysis patients. Patients on dialysis with HCV infection treated with pegylated interferon (Peg-INF) monotherapy were studied. All patients were subjected to HCV-polymerase chain reaction, viral load, genotype, and liver biopsy. Quantitative HCV-RNA was performed monthly. Patients with genotype 1 and 4 were given 12 month therapy while those with genotypes 2 and 3 were given 6 months therapy. Response was classified as per standard criteria of rapid virological response (RVR), early virological response (EVR), end of treatment response (ETR), and sustained virological response (SVR)...
July 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27484467/inflammatory-bowel-disease-mimicking-granulomatosis-with-polyangiitis-a-case-report
#18
Samantha C Shapiro, Armen Khararjian, Rebecca L Manno
BACKGROUND: We report a case in which the extraintestinal manifestations of inflammatory bowel disease preceded development of gastrointestinal symptoms by nearly 9 months in the context of an unusual autoantibody panel, mimicking granulomatosis with polyangiitis. This case highlights the intricacies and overlap of autoimmune diseases, and illustrates an interesting clinical phenotype: cytoplasmic anti-neutrophil cytoplasmic antibody positive inflammatory bowel disease with predominantly extraintestinal manifestations...
August 2, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27335873/electrophysiological-study-of-the-antinociception-produced-by-the-coapplication-of-%C3%A2-cpp-and-propentofylline-in-monoarthritic-rats
#19
Claudio Laurido, José L Martínez, Francisco Morales
The NMDA receptor is central in the generation and maintenance of chronic pain. This receptor has several sites of modulation. One is the glutamate recognition site that can be blocked by (±)-3-(2-carboxypiperazin-yl)propyl-1-phosphoric acid or (±)-CPP. We investigated whether the effect of glial inhibition produced by propentophylline (PPF) can be enhanced when combined with (±)-CPP. We used Sprague-Dawley rats with experimental monoarthritis, administering intrathecally the ED30 for both drugs (3.97 μg of (±)-CPP and 1...
2013: ISRN Pain
https://www.readbyqxmd.com/read/27325304/osteoid-osteoma-mimicking-monoarticular-juvenile-idiopathic-arthritis-in-a-girl
#20
Francesco Massei, Gianluigi Laccetta, Monica Barrani, Luca Fabbri, Virna Zampa, Alessandro Paolicchi, Roberto Cioni, Eugenio Mario Ciancia, Michelangelo Scaglione, Rita Consolini
Osteoid osteoma (OO) is a benign osteogenic neoplasm, usually affecting children and young adults, that is typically characterized by nocturnal pain and response to non-steroidal anti-inflammatory drugs. OO is frequently misdiagnosed because it mimics juvenile idiopathic arthritis (JIA), bone infection or malignancy. Herein we report the case of a girl who presented with chronic monoarthritis of the knee mimicking JIA. After 1 year, OO of the femoral distal metaphysis was diagnosed. OO was treated with computed tomography-guided radiofrequency ablation with disappearance of the symptoms and resolution of the neoplasm...
August 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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