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https://www.readbyqxmd.com/read/28740846/the-transmission-chain-analysis-of-2014-2015-ebola-virus-disease-outbreak-in-koinadugu-district-sierra-leone-an-observational-study
#1
Ifeanyi-Stanley Muoghalu, Francis Moses, Ishata Conteh, Patrick Swaray, Anthonia Ajudua, Anders Nordström
INTRODUCTION: Sierra Leone experienced an unprecedented Ebola virus disease (EVD) outbreak in all its districts. Koinadugu District was the last to report an EVD case. Several outbreak response strategies were implemented. As part of lessons learnt, we conducted an observational study to describe the transmission chain in the district and the impact of the control measures implemented to contain the outbreak. METHODS: We reconstructed the transmission chain, positioning both confirmed and probable cases, described the distribution of the EVD confirmed cases in the context of the routes of transmission (Community, Funeral or Health facility setting) and assessed the impact of control measures using the surveillance data collected during the outbreak...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28722630/the-effects-of-an-integrated-community-case-management-strategy-on-the-appropriate-treatment-of-children-and-child-mortality-in-kono-district-sierra-leone-a-program-evaluation
#2
Ruwan Ratnayake, Jeffrey Ratto, Colleen Hardy, Curtis Blanton, Laura Miller, Mary Choi, John Kpaleyea, Pheabean Momoh, Yolanda Barbera
Integrated community case management (iCCM) aims to reduce child mortality in areas with poor access to health care. iCCM was implemented in 2009 in Kono district, Sierra Leone, a postconflict area with high under-five mortality rates (U5MRs). We evaluated iCCM's impact and effects on child health using cluster surveys in 2010 (midterm) and 2013 (endline) to compare indicators on child mortality, coverage of appropriate treatment, timely access to care, quality of care, and recognition of community health workers (CHWs)...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722563/the-west-african-experience-in-establishing-steering-committees-for-better-collaboration-between-researchers-and-decision-makers-to-increase-the-use-of-health-research-findings
#3
Namoudou Keita, Virgil Lokossou, Abdramane Berthe, Issiaka Sombie, Ermel Johnson, Kofi Busia
BACKGROUND: Aware of the advantages of a project steering committee (SC) in terms of influencing the development of evidence-based health policies, the West African Health Organisation (WAHO) encouraged and supported the creation of such SCs around four research projects in four countries (Burkina Faso, Nigeria, Senegal and Sierra Leone). This study was conducted to describe the process that was used to establish these committees and its findings aim to assist other stakeholders in initiating this type of process...
July 12, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28722561/the-quality-of-free-antenatal-and-delivery-services-in-northern-sierra-leone
#4
Manso M Koroma, Samuel S Kamara, Evelyn A Bangura, Mohamed A Kamara, Virgil Lokossou, Namoudou Keita
BACKGROUND: The number of maternal deaths in sub-Saharan Africa continues to be overwhelmingly high. In West Africa, Sierra Leone leads the list, with the highest maternal mortality ratio. In 2010, financial barriers were removed as an incentive for more women to use available antenatal, delivery and postnatal services. Few published studies have examined the quality of free antenatal services and access to emergency obstetric care in Sierra Leone. METHODS: A cross-sectional survey was conducted in 2014 in all 97 peripheral health facilities and three hospitals in Bombali District, Northern Region...
July 12, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28722552/evaluation-of-regional-project-to-strengthen-national-health-research-systems-in-four-countries-in-west-africa-lessons-learned
#5
Issiaka Sombié, Jude Aidam, Gabriela Montorzi
BACKGROUND: Since the Commission on Health Research for Development (COHRED) published its flagship report, more attention has been focused on strengthening national health research systems (NHRS). This paper evaluates the contribution of a regional project that used a participatory approach to strengthen NHRS in four post-conflict West African countries - Guinea-Bissau, Liberia, Sierra Leone and Mali. METHODS: The data from the situation analysis conducted at the start of the project was compared to data from the project's final evaluation, using a hybrid conceptual framework built around four key areas identified through the analysis of existing frameworks...
July 12, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28721176/from-one-to-the-other-responding-to-ebola-cases-on-either-side-of-the-line
#6
Rebecca Day Merrill, Sadie Elizabeth Ward, Marydale Cauble Oppert, Dana Allison Schneider
This case study is adapted from events that occurred along the Sierra Leone and Guinea land border during the 2014-2016 Ebola epidemic in West Africa. The response activities involved Sierra Leone and Guinea officials, along with assistance from U.S. Centers for Disease Control and Prevention (CDC) and the World Health Organisation (WHO). This case study builds upon an understanding of basic surveillance systems and outbreak response activities. Through this exercise, students will understand how to incorporate communication and coordination into surveillance and response efforts with counterparts across the border in neighbouring countries...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28720090/-we-and-the-nurses-are-now-working-with-one-voice-how-community-leaders-and-health-committee-members-describe-their-role-in-sierra-leone-s-ebola-response
#7
Shannon A McMahon, Lara S Ho, Kerry Scott, Hannah Brown, Laura Miller, Ruwan Ratnayake, Rashid Ansumana
BACKGROUND: Across low-income settings, community volunteers and health committee members support the formal health system - both routinely and amid emergencies - by engaging in health services such as referrals and health education. During the 2014-2015 Ebola epidemic, emerging reports suggest that community engagement was instrumental in interrupting transmission. Nevertheless, literature regarding community volunteers' roles during emergencies generally, and Ebola specifically, is scarce...
July 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28716555/attitudes-about-vaccines-to-prevent-ebola-virus-disease-in-guinea-at-the-end-of-a-large-ebola-epidemic-results-of-a-national-household-survey
#8
Kathleen L Irwin, Mohamed F Jalloh, Jamaica Corker, Barry Alpha Mahmoud, Susan J Robinson, Wenshu Li, Nyuma E James, Musa Sellu, Mohammad B Jalloh, Alpha Ahmadou Diallo, LaRee Tracy, Rana Hajjeh, Amanda VanSteelandt, Rebecca Bunnell, Lise Martel, Pratima L Raghunathan, Barbara Marston
INTRODUCTION: In 2014-2016, an Ebola epidemic devastated Guinea; more than 3800 cases and 2500 deaths were reported to the World Health Organization. In August 2015, as the epidemic waned and clinical trials of an experimental, Ebola vaccine continued in Guinea and neighboring Sierra Leone, we conducted a national household survey about Ebola-related knowledge, attitudes, and practices (KAP) and opinions about "hypothetical" Ebola vaccines. METHODS: Using cluster-randomized sampling, we selected participants aged 15+ years old in Guinea's 8 administrative regions, which had varied cumulative case counts...
July 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28706988/unsustainable-development-pathways-caused-by-tropical-deforestation
#9
Luis Roman Carrasco, Thi Phuong Le Nghiem, Zhirong Chen, Edward B Barbier
Global sustainability strategies require assessing whether countries' development trajectories are sustainable over time. However, sustainability assessments are limited because losses of natural capital and its ecosystem services through deforestation have not been comprehensively incorporated into national accounts. We update the national accounts of 80 nations that underwent tropical deforestation from 2000 to 2012 and evaluate their development trajectories using weak and strong sustainability criteria...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28705016/education-and-social-inclusion-of-people-with-disabilities-in-five-countries-in-west-africa-a-literature-review
#10
Emma Jolley, Paul Lynch, Bhavisha Virendrakumar, Stacy Rowe, Elena Schmidt
PURPOSE: An estimated 1 billion people worldwide live with some form of disability. With the adoption of the Sustainable Development Goals and the "Leave no one behind" agenda, there is a global momentum to ensure that disadvantaged groups, not least people with disabilities, are included and accounted for, in mainstream development efforts. However, in many low-income settings little is known about disability and the policies and programs in place to improve the lives of those affected...
July 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28695354/mobile-health-clinic-for-the-medical-management-of-clinical-sequelae-experienced-by-survivors-of-the-2013-2016-ebola-virus-disease-outbreak-in-sierra-leone-west-africa
#11
R E Guetiya Wadoum, A Samin, N G Mafopa, M Giovanetti, G Russo, P Turay, J Turay, M Kargbo, M T Kanu, B Kargbo, J Akpablie, C J Cain, P Pasin, V Batwala, M S Sobze, M Potestà, A Minutolo, V Colizzi, C Montesano
An Ebola survivor Mobile Health Clinic (MHC) was established to implement lasting changes in communities it operates by providing effective and efficient mobile healthcare. After months of development, the MHC solution was operationalised in February 2015, aiming to provide integrated primary healthcare services to address the medical and psychosocial needs of Ebola virus (EBOV) survivors living in areas with low medical coverage. A total of 910 medical consultations for 246 EBOV survivors were performed between 7 February 2015 and 10 June 2016...
July 10, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28679759/mutational-analysis-of-lassa-virus-glycoprotein-highlights-regions-required-for-alpha-dystroglycan-utilization
#12
Marissa Acciani, Jacob T Alston, Guohui Zhao, Hayley Reynolds, Afroze M Ali, Brian Xu, Melinda A Brindley
Lassa virus (LASV) is an enveloped RNA virus endemic to West Africa and responsible for severe cases of hemorrhagic fever. Virus entry is mediated by the glycoprotein complex consisting of a stable signal peptide, a receptor-binding subunit GP1, and a viral-host membrane fusion subunit GP2. Several cellular receptors can interact with the GP1 subunit and mediate viral entry, including alpha-dystroglycan (αDG) and lysosomal associated membrane protein 1 (LAMP1). In order to define the regions within GP1 that interact with the cellular receptors, we implemented insertional mutagenesis, carbohydrate shielding, and alanine scanning mutagenesis...
July 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28679383/strengthening-close-to-community-provision-of-maternal-health-services-in-fragile-settings-an-exploration-of-the-changing-roles-of-tbas-in-sierra-leone-and-somaliland
#13
Evelyn Orya, Sunday Adaji, Thidar Pyone, Haja Wurie, Nynke van den Broek, Sally Theobald
BACKGROUND: Efforts to take forward universal health coverage require innovative approaches in fragile settings, which experience particularly acute human resource shortages and poor health indicators. For maternal and newborn health, it is important to innovate with new partnerships and roles for Traditional Birth Attendants (TBAs) to promote maternal health. We explore perspectives on programmes in Somaliland and Sierra Leone which link TBAs to health centres as part of a pathway to maternal health care...
July 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28675419/shock-progression-and-survival-after-use-of-a-condom-uterine-balloon-tamponade-package-in-women-with-uncontrolled-postpartum-hemorrhage
#14
Thomas F Burke, Sandra Danso-Bamfo, Moytrayee Guha, Monica Oguttu, Vincent Tarimo, Brett D Nelson
OBJECTIVE: To examine the outcomes of women in advanced shock from uncontrolled postpartum hemorrhage (PPH) who underwent placement of an Every Second Matters for Mothers and Babies Uterine Balloon Tamponade (ESM-UBT) device. METHODS: In a prospective case series, data were collected for women who received an ESM-UBT device at healthcare facilities in Kenya, Senegal, Sierra Leone, and Tanzania between September 1, 2012, and September 30, 2016. Shock class was assigned on the basis of recorded blood pressures and mental status at the time of UBT placement...
July 4, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28673837/respiratory-viruses-detected-in-mexican-children-younger-than-5-years-old-with-community-acquired-pneumonia-a-national-multicenter-study
#15
Rosa María Wong-Chew, Miguel L García-León, Daniel E Noyola, Luis F Pérez-González, Jesús Gaitán-Meza, Alberto Villaseñor-Sierra, Gerardo Martínez-Aguilar, Victor Hugo Rivera-Nuñez, Oscar A Newton-Sánchez, Verónica Firo-Reyes, Carlos N Del Río-Almendarez, Alejandra Pamela González-Rodríguez, Enrique R Ortiz-García, Susana Navarrete-Navarro, Carmen Soria-Rodríguez, Adoniram Carrasco-Castillo, Eneida Sánchez-Medina, Irma López-Martínez, Teresa Hernández-Andrade, Celia M Alpuche-Aranda, José I Santos-Preciado
BACKGROUND: Acute respiratory infections are the leading cause of mortality in children worldwide, especially in developing countries. Pneumonia accounts for 16% of all deaths of children under 5 years of age and was the cause of death of 935000 children in 2015. Despite its frequency and severity, information regarding its etiology is limited. The aim of this study was to identify respiratory viruses associated with community-acquired pneumonia (CAP) in children younger than 5 years old...
June 30, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28671714/significant-differentiation-in-the-apolipoprotein-a-lipoprotein-a-trait-between-chimpanzees-from-western-and-central-africa
#16
Asma Noureen, Claudius Ronke, Mahmoud Khalifa, Michel Halbwax, Anne Fischer, Claudine André, Rebeca Atencia, Rosa Garriga, Lawrence Mugisha, Uta Ceglarek, Joachim Thiery, Gerd Utermann, Konrad Schmidt
Elevated Lipoprotein(a) (Lp(a)) plasma concentrations are a risk factor for cardiovascular disease in humans, largely controlled by the LPA gene encoding apolipoprotein(a) (apo(a)). Lp(a) is composed of low-density lipoprotein (LDL) and apo(a) and restricted to Catarrhini. A variable number of kringle IV (KIV) domains in LPA lead to a size polymorphism of apo(a) that is inversely correlated with Lp(a) concentrations. Smaller apo(a) isoforms and higher Lp(a) levels in central chimpanzees (Pan troglodytes troglodytes [PTT]) compared to humans from Europe had been reported...
July 3, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28669680/hepatitis-c-virus-core-antigen-in-the-management-of-patients-treated-with-new-direct-acting-antivirals
#17
Juan Carlos Alados Arboledas, Inmaculada Pavón Guerrero, María José Blanco Rodríguez, Eva Torres Martos, Ana Belén Pérez, Cristina Cepero León, Jesus F Sierra Sánchez, María Dolores López Prieto, Natalia Chueca Porcuna, María Dolores Ocete Mochón, Juan Macías, Alberto de la Iglesia Salgado, Javier Rodríguez Granger, Marcial Delgado Fernández, Inmaculada Guerrero Lozano, Elena Reigadas Ramírez, Antonio Rivero, María Del Carmen Lozano Domínguez, Isabel Viciana, Juan Carlos Galán Montemayor, Federico García García
We evaluated the utility of Architect core antigen assay® Abbott Diagnostics (HCVAg) for monitoring patients with HCV infection and compared to HCV-RNA quantification (Cobas Ampliprep TaqMan-Roche Diagnostics). Samples from 262 patients were studied. Mean baseline HCV RNA and HCVAg levels were similar for responders (6.2 log IU/mL and 3.4 log fmol/L) and non-responders (6.1 log IU/mL and 3.2 log fmol/L), respectively. Only 10 patients failed to achieve SVR12 and all were detected by both assays. To evaluate HCVAg quantification as a tool for the detection of failure to DAAs, we performed a retrospective study of 132 non-responder patients...
June 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28668230/global-funding-trends-for-malaria-research-in-sub-saharan-africa-a-systematic-analysis
#18
Michael G Head, Sian Goss, Yann Gelister, Victor Alegana, Rebecca J Brown, Stuart C Clarke, Joseph R A Fitchett, Rifat Atun, J Anthony G Scott, Marie-Louise Newell, Sabu S Padmadas, Andrew J Tatem
BACKGROUND: Total domestic and international funding for malaria is inadequate to achieve WHO global targets in burden reduction by 2030. We describe the trends of investments in malaria-related research in sub-Saharan Africa and compare investment with national disease burden to identify areas of funding strength and potentially neglected populations. We also considered funding for malaria control. METHODS: Research funding data related to malaria for 1997-2013 were sourced from existing datasets, from 13 major public and philanthropic global health funders, and from funding databases...
June 28, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28662093/diversity-of-inland-valleys-and-opportunities-for-agricultural-development-in-sierra-leone
#19
Elliott Ronald Dossou-Yovo, Idriss Baggie, Justin Fagnombo Djagba, Sander Jaap Zwart
Inland valleys are becoming increasingly important agricultural production areas for rural households in sub-Saharan Africa due to their relative high and secure water availability and soil fertility. In addition, inland valleys are important as water buffer and biodiversity hot spots and they provide local communities with forest, forage, and fishing resources. As different inland-valley ecosystem functions may conflict with agricultural objectives, indiscriminate development should be avoided. This study aims to analyze the diversity of inland valleys in Sierra Leone and to develop guidelines for more precise interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28653373/association-between-parkinson-s-disease-and-diabetes-data-from-nedices-study
#20
E De Pablo-Fernandez, F Sierra-Hidalgo, J Benito-León, F Bermejo-Pareja
BACKGROUND: Despite growing evidence showing an association between Parkinson's disease (PD) and diabetes, epidemiological studies have shown conflicting results. AIMS OF THE STUDY: To evaluate the association between PD and diabetes and the impact of diabetes duration in this association in an elderly (≥65 years) Spanish population. METHODS: Data for this cross-sectional population-based analysis were obtained from NEDICES study. Subjects were identified from census list...
June 26, 2017: Acta Neurologica Scandinavica
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