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https://www.readbyqxmd.com/read/28079420/international-nursing-reflections-on-working-in-sierra-leone
#1
Sergeant Julie Jones
Registered Nurse, 4626 (AE) Sqn, RAuxAF, RAF Brize Norton/Nurse Practitioner, Center Parcs Sherwood Forest, Nottinghamshire looks back over her time working in A&E in Sierra Leone.
January 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28074385/use-of-a-cd-laser-pickup-head-to-fabricate-microelectrodes-in-polymethylmethacrylate-substrates-for-biosensing-applications
#2
Jehú López-Aparicio, Mathieu Hautefeuille, Sara Herrera-Domínguez, Adriana Razo-de-León, Mariel Cano-Jorge, Ixchetl Rojas-Benito, Mariana Centeno-Sierra, Tatiana Fiordelisio-Coll, Catalina Elizabeth Stern-Forgach
In this work, we report a simple fabrication method for microelectrodes on a polymethylmethacrylate substrate, using a low-cost laser platform based on a CD-DVD unit for direct rapid-prototyping. We used this laser microfabrication technique to etch any desired design on polymethylmethacrylate substrates to produce microchannels with controlled geometry, with a highly repeatable micron-scale resolution. Those shallow microchannels were then filled with a conductive paste of material of our choice that was converted into microelectrodes of desired shapes and geometries after drying...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28065195/programming-maternal-and-child-overweight-and-obesity-in-the-context-of-undernutrition-current-evidence-and-key-considerations-for-low-and-middle-income-countries
#3
Lindsay M Jaacks, Justine Kavle, Abigail Perry, Albertha Nyaku
The goals of the present targeted review on maternal and child overweight and obesity were to: (i) understand the current situation in low- and middle-income countries (LMIC) with regard to recent trends and context-specific risk factors; and (ii) building off this, identify entry points for leveraging existing undernutrition programmes to address overweight and obesity in LMIC. Trends reveal that overweight and obesity are a growing problem among women and children in LMIC; as in Ghana, Kenya, Niger, Sierra Leone, Tanzania and Zimbabwe, where the prevalence among urban women is approaching 50 %...
January 9, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28061463/prevalence-of-psychological-symptoms-among-ebola-survivors-and-healthcare-workers-during-the-2014-2015-ebola-outbreak-in-sierra-leone-a-cross-sectional-study
#4
Dong Ji, Ying-Jie Ji, Xue-Zhang Duan, Wen-Gang Li, Zhi-Qiang Sun, Xue-Ai Song, Yu-Hua Meng, Hong-Mei Tang, Fang Chu, Xiao-Xia Niu, Guo-Feng Chen, Jin Li, Hui-Juan Duan
The 2014-2015 Ebola epidemic was considered to be the largest and most complex outbreak, which caused 11,310 reported deaths. The epidemic disease can cause a mental health crisis, however, there is only a small amount of scientific literature available related to this health issue so far. We evaluated the psychological symptoms of 161 participants including Ebola survivors and healthcare workers in Sierra Leone, analyzed the impact of job classification, education level on psychological status. We found that the order of total general severity index (GSI) scores from high to low was EVD survivors, SL medical staff, SL logistic staff, SL medical students, and Chinese medical staff...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28056096/detection-of-viral-rna-in-tissues-following-plasma-clearance-from-an-ebola-virus-infected-patient
#5
Mirella Biava, Claudia Caglioti, Licia Bordi, Concetta Castilletti, Francesca Colavita, Serena Quartu, Emanuele Nicastri, Francesco Nicola Lauria, Nicola Petrosillo, Simone Lanini, Thomas Hoenen, Gary Kobinger, Alimuddin Zumla, Antonino Di Caro, Giuseppe Ippolito, Maria Rosaria Capobianchi, Eleonora Lalle
An unprecedented Ebola virus (EBOV) epidemic occurred in 2013-2016 in West Africa. Over this time the epidemic exponentially grew and moved to Europe and North America, with several imported cases and many Health Care Workers (HCW) infected. Better understanding of EBOV infection patterns in different body compartments is mandatory to develop new countermeasures, as well as to fully comprehend the pathways of human-to-human transmission. We have longitudinally explored the persistence of EBOV-specific negative sense genomic RNA (neg-RNA) and the presence of positive sense RNA (pos-RNA), including both replication intermediate (antigenomic-RNA) and messenger RNA (mRNA) molecules, in the upper and lower respiratory tract, as compared to plasma, in a HCW infected with EBOV in Sierra Leone, who was hospitalized in the high isolation facility of the National Institute for Infectious Diseases "Lazzaro Spallanzani" (INMI), Rome, Italy...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28052985/experiences-of-using-life-histories-with-health-workers-in-post-conflict-and-crisis-settings-methodological-reflections
#6
Sophie Witter, Justine Namakula, Alvaro Alonso-Garbayo, Haja Wurie, Sally Theobald, Wilson Mashange, Bandeth Ros, Stephen Buzuzi, Richard Mangwi, Tim Martineau
INTRODUCTION: Life history is a research tool which has been used primarily in sociology and anthropology to document experiences of marginalized individuals and communities. It has been less explored in relation to health system research. In this paper, we examine our experience of using life histories to explore health system trajectories coming out of conflict through the eyes of health workers. METHODS: Life histories were used in four inter-related projects looking at health worker incentives, the impact of Ebola on health workers, deployment policies, and gender and leadership in the health sector...
January 4, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28049495/the-link-between-the-west-african-ebola-outbreak-and-health-systems-in-guinea-liberia-and-sierra-leone-a-systematic-review
#7
REVIEW
Haitham Shoman, Emilie Karafillakis, Salman Rawaf
BACKGROUND: An Ebola outbreak started in December 2013 in Guinea and spread to Liberia and Sierra Leone in 2014. The health systems in place in the three countries lacked the infrastructure and the preparation to respond to the outbreak quickly and the World Health Organisation (WHO) declared a public health emergency of international concern on August 8 2014. OBJECTIVE: The aim of this study was to determine the effects of health systems' organisation and performance on the West African Ebola outbreak in Guinea, Liberia and Sierra Leone and lessons learned...
January 4, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28042619/beating-the-odds-successful-establishment-of-a-phase-ii-iii-clinical-research-trial-in-resource-poor-liberia-during-the-largest-ever-ebola-outbreak
#8
J Doe-Anderson, B Baseler, P Driscoll, M Johnson, J Lysander, L McNay, W S Njoh, M Smolskis, L Wehrlen, J Zuckerman
It has been argued that a country such as Liberia, not fully recovered from the devastation of decades of civil unrest, lacked the appropriate ethical and regulatory framework, basic human and health care services, and infrastructure to carry out clinical trials according to international standards of quality during a public health emergency. However, as Liberia, Sierra Leone, and Guinea were being ravaged by the largest and most devastating Ebola Virus Disease (EVD) outbreak ever recorded, the topic of conducting clinical trials of experimental vaccine and treatment candidates in these resource-poor countries generated the keen interest and concern of scientists, researchers, physicians, bioethicists, philanthropists, and even politicians...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28041818/-prevention-and-nursing-care-in-the-first-case-of-ebola-virus-disease-contracted-outside-africa
#9
Alicia Cerón-Serrano, Rafael Jiménez-Castellano, Ana María Gómez-Campos
After the evacuation from Africa to Western hospitals of several international workers with the Ebola virus disease, the first case of contagion outside Africa occurred in Madrid, Spain. A nursing care assistant who had attended a missionary repatriated from Sierra Leone contracted the disease. On October 7(th) 2014, the patient arrived at the University Hospital La Paz-Carlos III in Madrid. She remained in the hospital for 30 days, 25 of which were in strict isolation in a negative pressure room with air lock anteroom; personal protective equipment was required...
December 29, 2016: Enfermería Clínica
https://www.readbyqxmd.com/read/28031301/social-mobilization-and-community-engagement-central-to-the-ebola-response-in-west-africa-lessons-for-future-public-health-emergencies
#10
Amaya M Gillespie, Rafael Obregon, Rania El Asawi, Catherine Richey, Erma Manoncourt, Kshiitij Joshi, Savita Naqvi, Ade Pouye, Naqibullah Safi, Ketan Chitnis, Sabeeha Quereshi
Following the World Health Organization (WHO) declaration of a Public Health Emergency of International Concern regarding the Ebola outbreak in West Africa in July 2014, UNICEF was asked to co-lead, in coordination with WHO and the ministries of health of affected countries, the communication and social mobilization component-which UNICEF refers to as communication for development (C4D)-of the Ebola response. For the first time in an emergency setting, C4D was formally incorporated into each country's national response, alongside more typical components such as supplies and logistics, surveillance, and clinical care...
December 23, 2016: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28024952/real-time-dynamic-modelling-for-the-design-of-a-cluster-randomized-phase-3-ebola-vaccine-trial-in-sierra-leone
#11
A Camacho, R M Eggo, N Goeyvaerts, A Vandebosch, R Mogg, S Funk, A J Kucharski, C H Watson, T Vangeneugden, W J Edmunds
BACKGROUND: Declining incidence and spatial heterogeneity complicated the design of phase 3 Ebola vaccine trials during the tail of the 2013-16 Ebola virus disease (EVD) epidemic in West Africa. Mathematical models can provide forecasts of expected incidence through time and can account for both vaccine efficacy in participants and effectiveness in populations. Determining expected disease incidence was critical to calculating power and determining trial sample size. METHODS: In real-time, we fitted, forecasted, and simulated a proposed phase 3 cluster-randomized vaccine trial for a prime-boost EVD vaccine in three candidate regions in Sierra Leone...
December 23, 2016: Vaccine
https://www.readbyqxmd.com/read/28017403/efficacy-and-effectiveness-of-an-rvsv-vectored-vaccine-in-preventing-ebola-virus-disease-final-results-from-the-guinea-ring-vaccination-open-label-cluster-randomised-trial-ebola-%C3%A3-a-suffit
#12
Ana Maria Henao-Restrepo, Anton Camacho, Ira M Longini, Conall H Watson, W John Edmunds, Matthias Egger, Miles W Carroll, Natalie E Dean, Ibrahima Diatta, Moussa Doumbia, Bertrand Draguez, Sophie Duraffour, Godwin Enwere, Rebecca Grais, Stephan Gunther, Pierre-Stéphane Gsell, Stefanie Hossmann, Sara Viksmoen Watle, Mandy Kader Kondé, Sakoba Kéïta, Souleymane Kone, Eewa Kuisma, Myron M Levine, Sema Mandal, Thomas Mauget, Gunnstein Norheim, Ximena Riveros, Aboubacar Soumah, Sven Trelle, Andrea S Vicari, John-Arne Røttingen, Marie-Paule Kieny
BACKGROUND: rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed cases in Guinea, west Africa. METHODS: We did an open-label, cluster-randomised ring vaccination trial (Ebola ça Suffit!) in the communities of Conakry and eight surrounding prefectures in the Basse-Guinée region of Guinea, and in Tomkolili and Bombali in Sierra Leone...
December 23, 2016: Lancet
https://www.readbyqxmd.com/read/28017399/safety-and-immunogenicity-of-a-recombinant-adenovirus-type-5-vector-based-ebola-vaccine-in-healthy-adults-in-sierra-leone-a-single-centre-randomised-double-blind-placebo-controlled-phase-2-trial
#13
Feng-Cai Zhu, Alie H Wurie, Li-Hua Hou, Qi Liang, Yu-Hua Li, James B W Russell, Shi-Po Wu, Jing-Xin Li, Yue-Mei Hu, Qiang Guo, Wen-Bo Xu, Abdul R Wurie, Wen-Juan Wang, Zhe Zhang, Wen-Jiao Yin, Manal Ghazzawi, Xu Zhang, Lei Duan, Jun-Zhi Wang, Wei Chen
BACKGROUND: A recombinant adenovirus type-5 vector-based vaccine expressing the glycoprotein of Ebola Zaire Makona variant showed good safety and immunogenicity in a phase 1 trial of healthy Chinese adults. We aimed to assess the safety and immunogenicity of this vaccine in healthy adults in Sierra Leone and to determine the optimal dose. METHODS: We did a single-centre, randomised, double-blind, placebo-controlled, phase 2 clinical trial at Sierra Leone-China Friendship Hospital, Freetown, Sierra Leone...
December 22, 2016: Lancet
https://www.readbyqxmd.com/read/28011610/characteristics-and-outcomes-of-pediatric-patients-with-ebola-virus-disease-admitted-to-treatment-units-in-liberia-and-sierra-leone-a-retrospective-cohort-study
#14
Michael A Smit, Ian C Michelow, Justin Glavis-Bloom, Vanessa Wolfman, Adam C Levine
: In a large, retrospective cohort of Ebola virus-infected children aged <18 years, the odds of death were ≥5-fold higher if patients were aged <5 years, had evidence of bleeding, or real-time polymerase chain reaction cycle threshold value ≤20. BACKGROUND: The clinical and virologic characteristics of Ebola virus disease (EVD) in children have not been thoroughly documented. METHODS: Consecutive children aged <18 years with real-time polymerase chain reaction (RT-PCR)-confirmed EVD were enrolled retrospectively in 5 Ebola treatment units in Liberia and Sierra Leone in 2014/2015...
October 25, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28005984/knowledge-and-skills-of-healthcare-providers-in-sub-saharan-africa-and-asia-before-and-after-competency-based-training-in-emergency-obstetric-and-early-newborn-care
#15
Charles A Ameh, Robert Kerr, Barbara Madaj, Mselenge Mdegela, Terry Kana, Susan Jones, Jaki Lambert, Fiona Dickinson, Sarah White, Nynke van den Broek
BACKGROUND: Healthcare provider training in Emergency Obstetric and Newborn Care (EmOC&NC) is a component of 65% of intervention programs aimed at reducing maternal and newborn mortality and morbidity. It is important to evaluate the effectiveness of this. METHODS: We evaluated knowledge and skills among 5,939 healthcare providers before and after 3-5 days 'skills and drills' training in emergency obstetric and newborn care (EmOC&NC) conducted in 7 sub-Saharan Africa countries (Ghana, Kenya, Malawi, Nigeria, Sierra Leone, Tanzania, Zimbabwe) and 2 Asian countries (Bangladesh, Pakistan)...
2016: PloS One
https://www.readbyqxmd.com/read/27997940/australia-s-response-to-ebola-virus-disease-in-west-africa-2014-15
#16
Gwendolyn L Gilbert
In March 2016, the World Health Organization declared the 2014-15 Ebola virus disease (EVD) outbreak officially over. With around 29 000 cases and 11 000 deaths in 27 months, this EVD outbreak was more than 60 times larger than any before, and unique in its cross-border spread and involvement of urban centres. Local and international responses were slow and initially inadequate, but establishment of the United Nations Mission for Ebola Emergency Response, 9 months after the outbreak began, allowed a coordinated effort that slowed and eventually controlled the spread of disease...
December 14, 2016: Public Health Research & Practice
https://www.readbyqxmd.com/read/27983503/sequelae-and-other-conditions-in-ebola-virus-disease-survivors-sierra-leone-2015
#17
Hamish Mohammed, Alren O Vandy, Rebecca Stretch, David Otieno, Mukesh Prajapati, Mauricio Calderon, Mohamed Vandi
We rapidly assessed the health of Ebola virus disease (EVD) survivors in Kenema, Sierra Leone, by reviewing medical charts of all patients attending the Survivor Clinic of Kenema Government Hospital. Data were abstracted on signs and symptoms at every attendance. As of November 2015, a total of 621 attendances by 115 survivors with laboratory-confirmed EVD were made to the Survivor Clinic. Most (60.9%) survivors were women. Survivors' median age was 28 years (range 0.25-70 years). Survivors attended the clinic a median of 5 times (range 1-21 times) each, and the median time from EVD discharge to attendance was 261 days (range 4-504 days)...
2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27974018/risky-sexual-behaviour-among-women-does-economic-empowerment-matter-case-of-gabon-mozambique-sierra-leone-and-zambia
#18
Clifford O Odimegwu, Nicole De Wet, Pamela C Banda
The link between economic empowerment and high risky sexual behaviour has been debated by different scholars in various settings. However, no consistently clear connection between poverty and lack of education has been found regarding engagement in risky sexual behaviour. Also, not much research has been done to examine the strength of these relationships for adolescents and women. The objectives of this study were to assess the relationship between female economic empowerment and risky sexual behaviour in Africa...
December 2016: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/27972276/cost-of-ebola-virus-disease-diagnosis-using-rapid-point-of-care-diagnostics-in-sierra-leone
#19
J S Evans, N C Hearmon, R C Beale, W Marsh
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956578/the-cuban-response-to-the-ebola-epidemic-in-west-africa-lessons-in-solidarity
#20
Enrique Beldarraín Chaple, Mary Anne Mercer
In December 2013 the first case of Ebola appeared in Guinea. In September 2014 the United Nations (UN) and its specialized agency the World Health Organization (WHO) issued a call for medical collaboration in response to the medical crisis and social disaster caused by the Ebola virus epidemic in West Africa. Cuban authorities responded immediately to the call by offering specialized help for the epidemic, in collaboration with WHO. A group of 256 Cuban doctors, nurses and other health professionals provided direct care during the Ebola epidemic in Sierra Leone, Liberia and Equatorial Guinea from October 2014 to April 2015...
January 2017: International Journal of Health Services: Planning, Administration, Evaluation
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