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https://www.readbyqxmd.com/read/29777712/speckle-type-poz-protein-suppresses-hepatocellular-carcinoma-cell-migration-and-invasion-via-ubiquitin-dependent-proteolysis-of-sumo1-sentrin-specific-peptidase-7
#1
Piyou Ji, Shaohua Liang, Pengtao Li, Chengrong Xie, Jie Li, Kang Zhang, Xuqing Zheng, Min Feng, Qiu Li, Hui Jiao, Xiaoqin Chi, Wenxiu Zhao, Sheng Zhang, Xiaomin Wang
Hepatocellular carcinoma (HCC) is associated with high metastatic potential and high mortality. Accumulating evidence has demonstrated that speckle-type POZ protein (SPOP) is a key adaptor molecule of ubiquitination. However, the molecular mechanism of SPOP-mediated ubiquitination in HCC metastasis remains obscure. In the present study, our results indicated that SPOP expression was significantly downregulated in HCC and was associated with tumor size, differentiation and metastasis. Cox regression model showed that low SPOP expression was a risk factor related to the prognosis of HCC patients...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29774187/multimodality-imaging-for-the-quantitative-assessment-of-mitral-regurgitation
#2
REVIEW
Pei G Chew, Katrina Bounford, Sven Plein, Dominik Schlosshan, John P Greenwood
The natural history of mitral regurgitation (MR) results in significant morbidity and mortality. Innovations in non-invasive imaging have provided new insights into the pathophysiology and quantification of MR, in addition to early detection of left ventricular (LV) dysfunction and prognostic assessment in asymptomatic patients. Transthoracic (TTE) and transesophageal (TOE) echocardiography are the mainstay for diagnosis, assessment and serial surveillance. However, the advance from 2D to 3D imaging leads to improved assessment and characterization of mitral valve (MV) disease...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29773831/dnajc17-is-localized-in-nuclear-speckles-and-interacts-with-splicing-machinery-components
#3
A Pascarella, G Ferrandino, S C Credendino, C Moccia, F D'Angelo, B Miranda, C D'Ambrosio, P Bielli, O Spadaro, M Ceccarelli, A Scaloni, C Sette, M De Felice, G De Vita, E Amendola
DNAJC17 is a heat shock protein (HSP40) family member, identified in mouse as susceptibility gene for congenital hypothyroidism. DNAJC17 knockout mouse embryos die prior to implantation. In humans, germline homozygous mutations in DNAJC17 have been found in syndromic retinal dystrophy patients, while heterozygous mutations represent candidate pathogenic events for myeloproliferative disorders. Despite widespread expression and involvement in human diseases, DNAJC17 function is still poorly understood. Herein, we have investigated its function through high-throughput transcriptomic and proteomic approaches...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29770913/diagnostic-value-of-myocardial-deformation-pattern-in-children-with-noncompaction-cardiomyopathy
#4
Putri Yubbu, Hythem M Nawaytou, Renzo Calderon-Anyosa, Anirban Banerjee
The current echocardiographic diagnostic criteria for noncompaction cardiomyopathy (NCC) have variable sensitivity and low specificity. Moreover, there are limited data on the use of myocardial deformation imaging for early detection of myocardial dysfunction in children with NCC. We describe left ventricular (LV) deformation patterns in children with NCC, with the goal of identifying a potential diagnostic pattern. We prospectively enrolled 30 children with NCC (47% male; mean age 7.2 years) and 30 age- and gender-matched controls...
May 16, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29769030/in-silico-simulation-of-liver-crack-detection-using-ultrasonic-shear-wave-imaging
#5
Erwei Nie, Jiao Yu, Debaditya Dutta, Yanying Zhu
BACKGROUND: Liver trauma is an important source of morbidity and mortality worldwide. A timely detection and precise evaluation of traumatic liver injury and the bleeding site is necessary. There is a need to develop better imaging modalities of hepatic injuries to increase the sensitivity of ultrasonic imaging techniques for sites of hemorrhage caused by cracks. In this study, we conduct an in silico simulation of liver crack detection and delineation using an ultrasonic shear wave imaging (USWI) based method...
May 16, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29768216/the-rna-exosome-adaptor-zfc3h1-functionally-competes-with-nuclear-export-activity-to-retain-target-transcripts
#6
Toomas Silla, Evdoxia Karadoulama, Dawid Mąkosa, Michal Lubas, Torben Heick Jensen
Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-coding products. Many transcripts are short lived due to their nuclear degradation by the ribonucleolytic RNA exosome. Here, we show that abolished nuclear exosome function causes the formation of distinct nuclear foci, containing polyadenylated (pA+ ) RNA secluded from nucleocytoplasmic export. We asked whether exosome co-factors could serve such nuclear retention. Co-localization studies revealed the enrichment of pA+ RNA foci with "pA-tail exosome targeting (PAXT) connection" components MTR4, ZFC3H1, and PABPN1 but no overlap with known nuclear structures such as Cajal bodies, speckles, paraspeckles, or nucleoli...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29766272/blood-pressure-is-normal-but-is-the-heart
#7
Serkan Fazlı Çelik, Cemşit Karakurt, Yılmaz Tabel, Taner Elmas, Saim Yoloğlu
BACKGROUND: There is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients. METHODS: Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography...
May 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29765052/coherent-x-rays-reveal-the-influence-of-cage-effects-on-ultrafast-water-dynamics
#8
Fivos Perakis, Gaia Camisasca, Thomas J Lane, Alexander Späh, Kjartan Thor Wikfeldt, Jonas A Sellberg, Felix Lehmkühler, Harshad Pathak, Kyung Hwan Kim, Katrin Amann-Winkel, Simon Schreck, Sanghoon Song, Takahiro Sato, Marcin Sikorski, Andre Eilert, Trevor McQueen, Hirohito Ogasawara, Dennis Nordlund, Wojciech Roseker, Jake Koralek, Silke Nelson, Philip Hart, Roberto Alonso-Mori, Yiping Feng, Diling Zhu, Aymeric Robert, Gerhard Grübel, Lars G M Pettersson, Anders Nilsson
The dynamics of liquid water feature a variety of time scales, ranging from extremely fast ballistic-like thermal motion, to slower molecular diffusion and hydrogen-bond rearrangements. Here, we utilize coherent X-ray pulses to investigate the sub-100 fs equilibrium dynamics of water from ambient conditions down to supercooled temperatures. This novel approach utilizes the inherent capability of X-ray speckle visibility spectroscopy to measure equilibrium intermolecular dynamics with lengthscale selectivity, by measuring oxygen motion in momentum space...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29760996/enhancement-of-morphological-and-vascular-features-in-oct-images-using-a-modified-bayesian-residual-transform
#9
Bingyao Tan, Alexander Wong, Kostadinka Bizheva
A novel image processing algorithm based on a modified Bayesian residual transform (MBRT) was developed for the enhancement of morphological and vascular features in optical coherence tomography (OCT) and OCT angiography (OCTA) images. The MBRT algorithm decomposes the original OCT image into multiple residual images, where each image presents information at a unique scale. Scale selective residual adaptation is used subsequently to enhance morphological features of interest, such as blood vessels and tissue layers, and to suppress irrelevant image features such as noise and motion artefacts...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29759782/regional-left-ventricular-electrical-activation-and-peak-contraction-are-closely-related-in-candidates-for-cardiac-resynchronization-therapy
#10
Masih Mafi-Rad, Jetske Van't Sant, Yuri Blaauw, Pieter A Doevendans, Maarten J Cramer, Harry J Crijns, Frits W Prinzen, Mathias Meine, Kevin Vernooy
OBJECTIVES: This study determined the relationship between the timing of left ventricular (LV) electrical activation and peak contraction at potential LV pacing locations in candidates for cardiac resynchronization therapy (CRT). BACKGROUND: Targeting the LV lead to the region of latest electrical activation or the segment of latest peak contraction has both been shown to improve CRT response. Whether these regions correspond within CRT patients is uncertain. METHODS: Twenty-eight consecutive CRT candidates underwent intraprocedural coronary venous electroanatomic mapping using EnSite NavX...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29757231/speckle-filtering-of-gf-3-polarimetric-sar-data-with-joint-restriction-principle
#11
Jinwei Xie, Zhenfang Li, Chaowei Zhou, Yuyuan Fang, Qingjun Zhang
Polarimetric SAR (PolSAR) scattering characteristics of imagery are always obtained from the second order moments estimation of multi-polarization data, that is, the estimation of covariance or coherency matrices. Due to the extra-paths that signal reflected from separate scatterers within the resolution cell has to travel, speckle noise always exists in SAR images and has a severe impact on the scattering performance, especially on single look complex images. In order to achieve high accuracy in estimating covariance or coherency matrices, three aspects are taken into consideration: (1) the edges and texture of the scene are distinct after speckle filtering; (2) the statistical characteristic should be similar to the object pixel; and (3) the polarimetric scattering signature should be preserved, in addition to speckle reduction...
May 12, 2018: Sensors
https://www.readbyqxmd.com/read/29756927/low-dose-x-ray-speckle-visibility-spectroscopy-reveals-nanoscale-dynamics-in-radiation-sensitive-ionic-liquids
#12
Jan Verwohlt, Mario Reiser, Lisa Randolph, Aleksandar Matic, Luis Aguilera Medina, Anders Madsen, Michael Sprung, Alexey Zozulya, Christian Gutt
X-ray radiation damage provides a serious bottleneck for investigating microsecond to second dynamics on nanometer length scales employing x-ray photon correlation spectroscopy. This limitation hinders the investigation of real time dynamics in most soft matter and biological materials which can tolerate only x-ray doses of kGy and below. Here, we show that this bottleneck can be overcome by low dose x-ray speckle visibility spectroscopy. Employing x-ray doses of 22-438 kGy and analyzing the sparse speckle pattern of count rates as low as 6...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756685/evaluation-of-right-ventricular-myocardial-strains-by-speckle-tracking-echocardiography-after-percutaneous-device-closure-of-atrial-septal-defects-in-children
#13
Qiuqin Xu, Ling Sun, Wanping Zhou, Yunjia Tang, Yueyue Ding, Jie Huang, Hui Wang, Cui Hou, Haitao Lv
OBJECTIVES: The aim of this study was to clarify the influence of the ASD closure by occluder device on right ventricular acute and long-term changes in longitudinal systolic strains, by evaluating right ventricular wall deformation in children using speckle tracking echocardiography (STE). METHODS AND MATERIALS: We enrolled 30 children with ASDs and 40 controls in our study. The Amplatzer atrial defect occluder was used to close the ASDs. Transthoracic echocardiographic examinations were performed at 3 points in time: the day before closure, 1 day after closure, and 3 months after closure...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29756381/myocardial-multilayer-strain-does-not-provide-additional-value-for-detection-of-myocardial-viability-assessed-by-spect-imaging-over-and-beyond-standard-strain
#14
Elisabeth Orloff, Pauline Fournier, Frédéric Bouisset, Thomas Moine, Maxime Cournot, Meyer Elbaz, Didier Carrié, Michel Galinier, Olivier Lairez, Thomas Cognet
BACKGROUND: The aim of this study was to evaluate the value of multilayer strain analysis to the assessment of myocardial viability (MV) through the comparison of both speckle tracking echocardiography and single-photon emission computed tomography (SPECT) imaging. We also intended to determine which segmental longitudinal strain (LS) cutoff value would be optimal to discriminate viable myocardium. METHODS: We included 47 patients (average age: 61 ± 11 years) referred to our cardiac imaging center for MV evaluation...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29753516/is-endothelial-microvascular-function-equally-impaired-among-patients-with-chronic-chagas-and-ischemic-cardiomyopathy
#15
Juliana Pereira Borges, Fernanda de Souza Nogueira Sardinha Mendes, Gabriella de Oliveira Lopes, Andréa Silvestre de Sousa, Mauro Felippe Felix Mediano, Eduardo Tibiriçá
BACKGROUND: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associated with the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCC remains to be elucidated. Thus, we compared the microvascular endothelial function of patients presenting with CCC to those with ischemic cardiomyopathy disease...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29752393/cardiac-structural-remodeling-longitudinal-systolic-strain-and-torsional-mechanics-in-lean-and-nonlean-dysglycemic-chinese-adults
#16
Jiun-Lu Lin, Kuo-Tzu Sung, Cheng-Huang Su, Tzu-Hsun Chou, Chi-In Lo, Jui-Peng Tsai, Shun-Chuan Chang, Yau-Huei Lai, Kuang-Chun Hu, Chia-Yuan Liu, Chun-Ho Yun, Chung-Lieh Hung, Hung-I Yeh, Carolyn S P Lam
BACKGROUND: Diabetes mellitus and pre-diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. METHODS AND RESULTS: We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29751525/demonstration-of-a-speckle-based-sensing-with-pulse-doppler-radar-for-vibration-detection
#17
Nisan Ozana, Reuven Bauer, Koby Ashkenazy, Nissim Sasson, Ariel Schwarz, Amir Shemer, Zeev Zalevsky
In previous works, an optical technique for extraction and separation of remote static vibrations has been demonstrated. In this paper, we will describe an approach in which RF speckle movement is used to extract remote vibrations of a static target. The use of conventional radar Doppler methods is not suitable for detecting vibrations of static targets. In addition, the speckle method has an important advantage, in that it is able to detect vibrations at far greater distances than what is normally detected in classical optical methods...
May 3, 2018: Sensors
https://www.readbyqxmd.com/read/29750229/left-ventricular-twist-before-and-after-haemodialysis-an-analysis-using-speckle-tracking-echocardiography
#18
Anthony Yip, Saraladevi Naicker, Ferande Peters, Elena Libhaber, Nirvathi Maharaj, Mduduzi Mashabane, Mohammed Rafique Essop
BACKGROUND: The most commonly used parameter of cardiac function in the chronic kidney disease (CKD) patient is ejection fraction (EF), using transthoracic echocardiography (TTE). EF is a highly load-dependent measurement, which varies considerably in CKD patients undergoing haemodialysis. The aim of this pilot study was to evaluate a novel measure of myocardial function, left ventricular twist, which is defined as the 'wringing action of the heart', using speckletracking echocardiography in CKD patients before and after haemodialysis...
April 20, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29749652/evolution-of-echocardiography-in-subclinical-detection-of-cancer-therapy-related-cardiac-dysfunction
#19
REVIEW
Rohit Moudgil, Saamir Hassan, Nicolas Palaskas, Juan Lopez-Mattei, Jose Banchs, Syed Wamique Yusuf
Cancer therapies have resulted in increased survivorship in oncological patients. However, the benefits have been marred by the development of premature cardiovascular disease. The current definition outlines measurement of ejection fraction as a mean to diagnose cancer therapeutic-related cardiac dysfunction (CTRCD); however, up to 58% of the patients do not regain their cardiac function after the CTRCD diagnosis, despite therapeutic interventions. Therefore, there has been a growing interest in the markers for early myocardial changes (ie, changes with normal left ventricular ejection fraction [LVEF]) that may predict the development of subsequent left ventricular ejection fraction reduction or progression to heart failure...
May 11, 2018: Echocardiography
https://www.readbyqxmd.com/read/29749646/left-and-right-ventricular-morphology-and-function-in-athletes-with-elevated-pulmonary-systolic-arterial-pressure
#20
Oana Mirea, Oana M Corîci, Octavian Istrătoaie, Ionuț Donoiu, Maria Iancău, Constantin Militaru
OBJECTIVES: The objective of the study was to evaluate the prevalence and potential impact of elevated pulmonary arterial systolic pressure (PASP) on left and right cardiac morphology and function in young elite athletes. METHODS: In total, 85 professional athletes (40 endurance, 20 strength, and 25 mixed training, mean age 17.8 ± 4.0) and 50 sedentary controls (mean age 18.6 ± 3.3) underwent transthoracic echocardiographic examination. Two-dimensional measurements of the right (RV) and left ventricle (LV) were obtained...
May 11, 2018: Echocardiography
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