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https://www.readbyqxmd.com/read/27691934/outcomes-of-cochlear-implantation-in-patients-with-neurofibromatosis-type-2
#1
Hannah J D North, Deborah Mawman, Martin O'Driscoll, Simon R Freeman, Scott A Rutherford, Andrew T King, Charlotte Hammerbeck-Ward, D Gareth Evans, Simon K W Lloyd
In neurofibromatosis type 2 (NF2) bilateral vestibular schwannomas (VS) or their treatment usually results in bilateral hearing loss. Cochlear implantation (CI) was traditionally not used in these patients due to concern that retrocochlear disease would render the implant ineffective. This paper describes the auditory outcomes of CI in 13 patients with NF2 and includes patients with untreated VS and patients undergoing VS removal with cochlear nerve preservation. The non-user rate was 7.7%. Of the active users, median CUNY score was 98%, median BKB score in quiet was 90% and median BKB score in noise was 68%...
July 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/27099106/cochlear-implantation-in-early-deafened-late-implanted-adults-do-they-benefit
#2
Raghunandhan Sampath Kumar, Deborah Mawman, Divyan Sankaran, Christine Melling, Martin O'Driscoll, Simon M Freeman, Simon K W Lloyd
OBJECTIVES: The aim of this study was to quantify the benefit gained from cochlear implantation in pre- or peri-lingually deafened patients who were implanted as adults Methods: This was a retrospective case-control study. Auditory (BKB/CUNY/3AFC/Environmental sounds), quality of life (GBI/HUI3) and cognitive (customized questionnaire) outcomes in 26 late implanted pre- or peri-lingually deafened adults were compared to those of 30 matched post-lingually deafened, traditional cochlear implant users...
April 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/25313415/treatment-of-severe-or-progressive-kaposi-s-sarcoma-in-hiv-infected-adults
#3
REVIEW
Oluwatoyin F Gbabe, Charles I Okwundu, Martin Dedicoat, Esther E Freeman
Background Kaposi's sarcoma remains the most common cancer in Sub-Saharan Africa and the second most common cancer in HIV-infected patients worldwide. Since the introduction of highly active antiretroviral therapy (HAART), there has been a decline in its incidence.However, Kaposi's sarcoma continues to be diagnosed in HIV-infected patients.Objectives To assess the added advantage of chemotherapy plus HAART compared to HAART alone; and the advantages of different chemotherapy regimens in HAART and HAART naive HIV infected adults with severe or progressive Kaposi's sarcoma...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25221796/treatment-of-severe-or-progressive-kaposi-s-sarcoma-in-hiv-infected-adults
#4
REVIEW
Oluwatoyin F Gbabe, Charles I Okwundu, Martin Dedicoat, Esther E Freeman
BACKGROUND: Kaposi's sarcoma remains the most common cancer in Sub-Saharan Africa and the second most common cancer in HIV-infected patients worldwide. Since the introduction of highly active antiretroviral therapy (HAART), there has been a decline in its incidence.However, Kaposi's sarcoma continues to be diagnosed in HIV-infected patients. OBJECTIVES: To assess the added advantage of chemotherapy plus HAART compared to HAART alone; and the advantages of different chemotherapy regimens in HAART and HAART naive HIV infected adults with severe or progressive Kaposi's sarcoma...
August 13, 2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24954049/deep-proteomics-of-the-xenopus-laevis-egg-using-an-mrna-derived-reference-database
#5
Martin Wühr, Robert M Freeman, Marc Presler, Marko E Horb, Leonid Peshkin, Steven P Gygi, Marc W Kirschner
BACKGROUND: Mass spectrometry-based proteomics enables the global identification and quantification of proteins and their posttranslational modifications in complex biological samples. However, proteomic analysis requires a complete and accurate reference set of proteins and is therefore largely restricted to model organisms with sequenced genomes. RESULTS: Here, we demonstrate the feasibility of deep genome-free proteomics by using a reference proteome derived from heterogeneous mRNA data...
July 7, 2014: Current Biology: CB
https://www.readbyqxmd.com/read/24251425/spatiotemporal-flow-of-information-in-the-early-visual-pathway
#6
Bartlett D Moore, Daniel L Rathbun, W Martin Usrey, Ralph D Freeman
The spatial components of a visual scene are processed neurally in a sequence of coarse features followed by fine features. This coarse-to-fine temporal stream was initially considered to be a cortical function, but has recently been demonstrated in the dorsal lateral geniculate nucleus. The goal of this study was to test the hypothesis that coarse-to-fine processing is present at earlier stages of visual processing in the retinal ganglion cells that supply lateral geniculate nucleus (LGN) neurons. To compare coarse-to-fine processing in the cat's visual system, we measured the visual responses of connected neuronal pairs from the retina and LGN, and separate populations of cells from each region...
February 2014: European Journal of Neuroscience
https://www.readbyqxmd.com/read/20393081/family-medicine-in-2018
#7
Keith D Ogle, Richard Boulé, R Jamie Boyd, Glenn Brown, Cathy Cervin, Martin Dawes, Tom Freeman, Marie Giroux, François Lehmann, Jacques Lemelin, Gilles Lortie, Cathy Maclean, Robert Miller, David Price, Preston Smith, G Richard Spooner, Lynn Wilson, Robert Woollard
No abstract text is available yet for this article.
April 2010: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/18350163/modulation-of-drosophila-retinal-epithelial-integrity-by-the-adhesion-proteins-capricious-and-tartan
#8
Yanlan Mao, Martin Kerr, Matthew Freeman
BACKGROUND: The development of the Drosophila eye imaginal disc requires complex epithelial rearrangements. Cells of the morphogenetic furrow are apically constricted and this leads to a physical indentation in the epithelium. Posterior to the furrow, cells start to rearrange into distinct clusters and eventually form a precisely patterned array of ommatidia. These morphogenetic processes include regulated changes of adhesion between cells. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that two transmembrane adhesion proteins, Capricious and Tartan, have dynamic and complementary expression patterns in the eye imaginal disc...
2008: PloS One
https://www.readbyqxmd.com/read/17512517/the-egfr-ligands-spitz-and-keren-act-cooperatively-in-the-drosophila-eye
#9
Katherine E Brown, Martin Kerr, Matthew Freeman
The EGFR signalling cascade is responsible for coordinating a wide variety of events during Drosophila eye development. It remains something of a mystery how it is that cells are able to interpret the signal so as to choose the appropriate response from the battery of possibilities: division, differentiation, cell shape change and so on. Since the cascade is essentially linear below the receptor, different cellular responses cannot be regulated by alternative signal transduction pathways. The main diversity lies upstream, in the multiple activating ligands...
July 1, 2007: Developmental Biology
https://www.readbyqxmd.com/read/17215530/sorafenib-in-advanced-clear-cell-renal-cell-carcinoma
#10
RANDOMIZED CONTROLLED TRIAL
Bernard Escudier, Tim Eisen, Walter M Stadler, Cezary Szczylik, Stéphane Oudard, Michael Siebels, Sylvie Negrier, Christine Chevreau, Ewa Solska, Apurva A Desai, Frédéric Rolland, Tomasz Demkow, Thomas E Hutson, Martin Gore, Scott Freeman, Brian Schwartz, Minghua Shan, Ronit Simantov, Ronald M Bukowski
BACKGROUND: We conducted a phase 3, randomized, double-blind, placebo-controlled trial of sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, in patients with advanced clear-cell renal-cell carcinoma. METHODS: From November 2003 to March 2005, we randomly assigned 903 patients with renal-cell carcinoma that was resistant to standard therapy to receive either continuous treatment with oral sorafenib (at a dose of 400 mg twice daily) or placebo; 451 patients received sorafenib and 452 received placebo...
January 11, 2007: New England Journal of Medicine
https://www.readbyqxmd.com/read/17008285/evidence-that-the-gonococcal-pora-pseudogene-is-present-in-a-broad-range-of-neisseria-gonorrhoeae-strains-suitability-as-a-diagnostic-target
#11
MULTICENTER STUDY
David M Whiley, Trevor P Anderson, Kevin Barratt, Miles H Beaman, Philip J Buda, Martine Carter, Kevin Freeman, Peter Hallsworth, E Athena Limnios, Gary Lum, Fabrice Merien, Frédérique Vernel-Pauillac, John W Tapsall, Michael J Witt, Michael D Nissen, Theo P Sloots
AIMS: The primary aim of the study was to determine if the gonococcal porA pseudogene is a stable sequence target for the detection of Neisseria gonorrhoeae by PCR. METHODS: A total of 240 gonococcal strains from various geographic locations were tested by porA pseudogene PCR. In addition, porA pseudogene PCR positivity rates were compared with established gonococcal assays in three Australian states. RESULTS: All N. gonorrhoeae isolates provided positive results in the porA pseudogene PCR...
October 2006: Pathology
https://www.readbyqxmd.com/read/16552300/parents-worries-about-recurrent-abdominal-pain-in-children
#12
Miranda A L van Tilburg, Neeta Venepalli, Martin Ulshen, Katherine L Freeman, Rona Levy, William E Whitehead
Recurrent abdominal pain is a common childhood disorder characterized by multiple episodes of stomachaches severe enough to interrupt daily activities. Recurrent abdominal pain is a difficult diagnosis for parents, children, and clinicians since there is no definitive cause of the symptoms. Research has shown recurrent abdominal pain is at least partly learned through social modeling. The purpose of this study was to understand parental worries and fears of recurrent abdominal pain that explain parental reinforcement of illness behavior...
January 2006: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/16253777/clusterin-as-a-therapeutic-target-for-radiation-sensitization-in-a-lung-cancer-model
#13
Carolyn Cao, Eric T Shinohara, Hecheng Li, Ken J Niermann, Kwang Woon Kim, Konjeti R Sekhar, Martin Gleave, Michael Freeman, Bo Lu
PURPOSE: Clusterin plays important roles in cell survival and death. Inactivation of clusterin enhances the therapeutic efficacy of chemotherapy in lung cancer models. The purpose of this study was to determine whether inhibition of clusterin by an antisense-based investigative drug enhances radiation sensitization in a lung cancer model. METHODS AND MATERIALS: Cells were transfected with an antisense oligonucleotide (ASO) against clusterin (OGX-011). Apoptosis was determined by 7-aminoactinomycin D staining...
November 15, 2005: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/12759412/differential-regulation-of-vitamin-d-receptor-and-its-ligand-in-human-monocyte-derived-dendritic-cells
#14
Martin Hewison, Lisa Freeman, Susan V Hughes, Katie N Evans, Rosemary Bland, Aristides G Eliopoulos, Mark D Kilby, Paul A H Moss, Ronjon Chakraverty
The functions of dendritic cells (DCs) are tightly regulated such that protective immune responses are elicited and unwanted immune responses are prevented. 1 alpha 25-dihydroxyvitamin D(3) (1 alpha 25(OH)(2)D(3)) has been identified as a major factor that inhibits the differentiation and maturation of DCs, an effect dependent upon its binding to the nuclear vitamin D receptor (VDR). Physiological control of 1 alpha 25(OH)(2)D(3) levels is critically dependent upon 25-hydroxyvitamin D(3)-1 alpha-hydroxylase (1 alpha OHase), a mitochondrial cytochrome P450 enzyme that catalyzes the conversion of inactive precursor 25-hydroxyvitamin D(3) (25(OH)D(3)) to the active metabolite 1 alpha 25(OH)(2)D(3)...
June 1, 2003: Journal of Immunology: Official Journal of the American Association of Immunologists
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