Marcela Daniela Ionescu, Bianca Prajescu, Roxana Taras, Nicoleta Popescu, Ruxandra Vidlescu, Mihaela Smarandoiu, Loredana-Elena Rosca, Augustina Enculescu, Elena Camelia Berghea, Claudia Lucia Toma
Hemophagocytic lymphohistiocytosis (HLH) is a rare, and potentially fatal, syndrome, characterized by immune system dysregulation, with excessive activation of the macrophages and cytotoxic T cells. It can be classified into primary (genetic) and secondary (acquired) forms. HLH presents with fever, hepatosplenomegaly, cytopenia, and hyperferritinemia, with involvement of various organs. The initial symptoms of HLH are non-specific, but as, if untreated, it can progress rapidly to multiorgan failure, timely diagnosis is essential...
March 13, 2024: Journal of Clinical Medicine