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https://www.readbyqxmd.com/read/28937791/web-based-surveillance-of-illness-in-childcare-centers
#1
Natalie Schellpfeffer, Abaigeal Collins, David C Brousseau, Emily T Martin, Andrew Hashikawa
School absenteeism is an inefficient and unspecific metric for measuring community illness and does not provide surveillance during summertime. Web-based biosurveillance of childcare centers may represent a novel way to efficiently monitor illness outbreaks year-round. A web-based biosurveillance program ( sickchildcare.org ) was created and implemented in 4 childcare centers in a single Michigan county. Childcare providers were trained to report sick children who required exclusion or had parent-reported absences due to illness...
September 22, 2017: Health Security
https://www.readbyqxmd.com/read/28928611/brugada-syndrome-in-children-stepping-into-unchartered-territory
#2
REVIEW
Shashank P Behere, Steven N Weindling
Brugada syndrome (BrS) is an autosomal dominant inherited channelopathy. It is associated with a typical pattern of ST-segment elevation in the precordial leads V1-V3 and potentially lethal ventricular arrhythmias in otherwise healthy patients. It is frequently seen in young Asian males, in whom it has previously been described as sudden unexplained nocturnal death syndrome. Although it typically presents in young adults, it is also known to present in children and infants, especially in the presence of fever...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28912993/bilateral-peritonsillar-abscess-in-an-infant-an-unusual-presentation-of-sore-throat
#3
Mariana Manzoni Seerig, Letícia Chueiri, Janaina Jacques, Maria Fernanda Piccoli Cardoso de Mello, Martin Batista Coutinho da Silva, Daniel Buffon Zatt, Rosana Cristine Otero Cunha, Andre Souza de Albuquerque Maranhão
INTRODUCTION: Peritonsillar abscess is considered a suppurative complication of acute tonsillitis. It is usually unilateral and clinically evident bilateral presentation is uncommon. The condition affects mainly children older than 10 years and young adults. Herein we present a rare case of bilateral peritonsillar abscess in an infant. PRESENTATION OF CASE: A 1-year-old boy presented with a two-day history of worsening sore throat, loss of appetite, vomiting, and fever...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28903515/update-from-the-advisory-committee-on-immunization-practices
#4
Sean T O'Leary, Yvonne A Maldonado, Carrie L Byington
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (C...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28902298/nursing-infant-with-acquired-toxoplasmosis-in-the-first-months-of-life-a-case-report
#5
Hanstter Hallison Alves Rezende, Heloísa Ribeiro Storchilo, Jaqueline Ataíde Silva Lima, Antônio Roberto Gomes, Taynara Cristina Gomes, Jéssica Yonara de Souza, Mariza Martins Avelino, Waldemar Naves do Amaral, Marina Clare Vinaud, Ana Maria de Castro
Toxoplasmosis is caused by Toxoplasma gondii and the probability of this infection occurring in the first months of life is usually low because its transmission is related to eating habits. A 6-month-old nursing infant was diagnosed with acute toxoplasmosis, which was identified through anti- T. gondii IgA, IgM and low-avidity IgG serologic assays, polymerase chain reaction (PCR) and mouse bioassay test although its mother was seronegative. This serological divergence between mother and child led us to interview the mother regarding epidemiological factors...
August 24, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28894118/persistence-of-zika-virus-in-conjunctival-fluid-of-convalescence-patients
#6
Jeslin J L Tan, Praveen K Balne, Yee-Sin Leo, Louis Tong, Lisa F P Ng, Rupesh Agrawal
A widespread epidemic of Zika fever, caused by Zika virus (ZIKAV) has spread throughout the Pacific islands, the Americas and Southeast Asia. The increased incidences of ocular anomalies observed in ZIKAV-infected infants and adults may be associated with the rapid spread of ZIKAV. The objective of this study was to check if ZIKAV could be detected in human tears after the first week of infection. Twenty-nine patients with PCR confirmed ZIKAV infection during the Singapore August 2016 ZIKAV outbreak were enrolled for the study...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887788/the-clinical-and-serological-profile-of-pediatric-dengue
#7
Sujatha Ramabhatta, Saravanan Palaniappan, Navya Hanumantharayappa, Shaik Vajidunnisa Begum
OBJECTIVE: To classify suspected dengue into dengue, dengue with warning signs and severe dengue, based on clinical features as per the revised WHO guidelines with special emphasis on serology. METHODS: It was a prospective cross-sectional study for five years from 2011-2016 in a tertiary care medical college hospital in Bangalore. All cases of fever of three to five days duration with symptoms like dengue were enrolled for the study. They were categorized into three groups as per the Revised WHO 2012 criteria...
September 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28881142/thermal-and-cytokine-responses-to-endotoxin-challenge-during-early-life
#8
Fiona Brigid McDonald, Ahmad M Khawaja, Ahmad Ali Imran, Margot E Ellis, Kumaran Chandrasekharan, Shabih U Hasan
Sudden infant death syndrome (SIDS) remains the leading cause of infant mortality beyond the neonatal period. An increase in body temperature as a result of high environmental temperature, over-wrapping of infants and/or infection are associated with SIDS. Endotoxins such as lipopolysaccharide (LPS) and heat stress may perturb cardiorespiratory function and thermoregulation. Although LPS-mediated body temperature and cytokine responses are well-documented in older animals, the capacity of LPS to induce fever and cytokine response in young rats remains unclear...
September 7, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28878869/the-mortality-of-ill-infants-with-false-tooth-extraction-in-a-rural-ugandan-emergency-department
#9
Amyna Husain, M Douglas Baker, Mark C Bisanzo, Martha W Stevens
False tooth extraction (FTE), a cultural practice in East Africa used to treat fever and diarrhea in infants, has been thought to increase infant mortality. The mortality of clinically similar infants with and without false tooth extraction has not previously been examined. The objective of our retrospective cohort study was to examine the mortality, clinical presentation, and treatment of infants with and without false tooth extraction. We conducted a retrospective chart review of records of infants with diarrhea, sepsis, dehydration, and fever in a rural Ugandan emergency department...
June 23, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28871880/clinical-factors-associated-with-chest-imaging-findings-in-hospitalized-infants-with-bronchiolitis
#10
Joanne M Nazif, Benjamin H Taragin, Gabriella Azzarone, Michael L Rinke, Sheila Liewehr, Jaeun Choi, Nora Esteban-Cruciani
Despite recommendations against routine imaging, chest radiography (CXR) is frequently performed on infants hospitalized for bronchiolitis. We conducted a review of 811 infants hospitalized for bronchiolitis to identify clinical factors associated with imaging findings. CXR was performed on 553 (68%) infants either on presentation or during hospitalization; 466 readings (84%) were normal or consistent with viral illness. Clinical factors significantly associated with normal/viral imaging were normal temperature (odds ratio = 1...
October 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28871368/infected-multilocular-hydrocephalus-treated-by-rigid-and-flexible-endoscopes-with-electromagnetic-guided-neuronavigation-a-case-report
#11
Ryuji Ishizaki, Yuzuru Tashiro
BACKGROUND: Endoscopic surgery assisted by a navigation system has greatly aided treatment of infected multilocular hydrocephalus, especially in children. CASE REPORT: We describe a 2-year-old boy with multilocular hydrocephalus caused by repeated shunt infection, presenting with fever and vomiting. Magnetic resonance images (MRI) showed extraventricular cysts and severe ventricular deformity. There were three ventriculoperitoneal shunts and one residual ventricular catheter...
September 4, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28866704/unexpected-infant-death-secondary-to-a-pulmonary-infiltration-due-to-acute-myelocytic-leukaemia
#12
M Ben Khelil, Y Chkirbene, M Mlika, S Haouet, M Hamdoun
Acute myeloid leukaemia (AML) often presents with non-specific symptoms such as fatigue, anaemia or infection. Pulmonary involvement is uncommon in AML during the course of the disease and is usually caused by infection, haemorrhage, leukaemic pulmonary infiltrates and leukostasis. Lung localization of AML is very uncommon and potentially life threatening if not diagnosed and treated rapidly. The authors describe the sudden death of an asymptomatic five-month-infant because of a misdiagnosed lung localization of AML...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28855716/a-genome-wide-association-analysis-identifies-nmnat2-and-hcp5-as-susceptibility-loci-for-kawasaki-disease
#13
Jae-Jung Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee Soo Ha, Sejung Sohn, Todd A Johnson, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee
Kawasaki disease (KD), a systemic vasculitis of infants and children, manifests as fever and mucocutaneous inflammation. Although its etiology is largely unknown, the epidemiological data suggest that genetic factors are important in KD susceptibility. To identify genetic variants influencing KD susceptibility, we performed a genome-wide association study (GWAS) and replication study using a total of 915 children with KD and 4553 controls in the Korean population. Six single-nucleotide polymorphisms (SNPs) in three loci were associated significantly with KD susceptibility (P<1...
August 31, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28855493/clinical-characteristics-of-17-adult-patients-with-epidemic-myalgia-associated-with-human-parechovirus-type-3-infection
#14
Tatsushi Yamakawa, Katsumi Mizuta, Katsurou Kurokawa, Hikaru Nagasawa, Takahiro Yamada, Emiko Suzuki, Manabu Wada
We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. In addition to myalgia and muscle weakness, symptoms included fever in 14 (82%), upper respiratory inflammation in 8 (47%), gastroenteritis in 4 (24%), and scrotal pain in 4 (29% of males) patients...
August 31, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28846945/colonic-mesenteric-lymphatic-malformation-presenting-as-an-intraabdominal-abscess-in-an-infant-a-case-report
#15
Gonakoti Sriram, Benjamin Zendejas, Sara O Vargas, Catherine Chen
INTRODUCTION: Lymphatic malformations are low-flow vascular malformations most commonly located in the head and neck; isolated intraabdominal involvement is rare. PRESENTATION OF CASE: An 8-month-old previously healthy male presented with a 9-day history of fevers. On examination, right-sided abdominal tenderness was noted. Ultrasound revealed a large heterogeneous mass, and CT scan revealed a rim-enhancing cystic mass adjacent to the right colon. Laboratory investigation including blood cultures was normal...
August 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28838147/specific-biomarkers-associated-with-neurological-complications-and-congenital-central-nervous-system-abnormalities-from-zika-virus-infected-patients-in-brazil
#16
Yiu-Wing Kam, Juliana Almeida Leite, Fok-Moon Lum, Jeslin J L Tan, Bernett Lee, Carla C Judice, Daniel Augusto de Toledo Teixeira, Robert Andreata-Santos, Marco A Vinolo, Rodrigo Angerami, Mariangela Ribeiro Resende, Andre Ricardo Ribas Freitas, Eliana Amaral, Renato Passini Junior, Maria Laura Costa, José Paulo Guida, Clarice Weis Arns, Luis Carlos S Ferreira, Laurent Rénia, Jose Luiz Proença-Modena, Lisa F P Ng, Fabio T M Costa
Background: Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations. Methods: We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas, Brazil. These patients included 6 pregnant women who later delivered during the course of this study. Clinical observations were recorded during hospitalization...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28836701/bsaci-guideline-for-the-diagnosis-and-management-of-peanut-and-tree-nut-allergy
#17
G Stiefel, K Anagnostou, R J Boyle, N Brathwaite, P Ewan, A T Fox, P Huber, D Luyt, S J Till, C Venter, A T Clark
Peanut nut and tree nut allergy are characterised by IgE mediated reactions to nut proteins. Nut allergy is a global disease. Limited epidemiological data suggest varying prevalence in different geographical areas. Primary nut allergy affects over 2% of children and 0.5% of adults in the UK. Infants with severe eczema and/or egg allergy have a higher risk of peanut allergy. Primary nut allergy presents most commonly in the first five years of life, often after the first known ingestion with typical rapid onset IgE-mediated symptoms...
June 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28834141/fatal-graft-versus-host-disease-after-living-donor-liver-transplantation-from-an-hla-dr-mismatched-donor
#18
Keita Shimata, Rieko Sakamoto, Tadashi Anan, Koushi Uchida, Masaki Honda, Masahiko Kouroki, Tomonari Urabe, Shintaro Hayashida, Hidekazu Yamamoto, Yasuhiko Sugawara, Yukihiro Inomata
Acute GVHD is a rare complication after liver transplantation that has a high mortality rate. We experienced an infant case complicated with acute GVHD. An 8-month-old infant with biliary atresia underwent LDLT with a graft obtained from his mother. Their HLAs showed a donor-dominant one-way match, not at HLA-DR but at HLA-A, HLA-B, and HLA-C (recipient; A 31/33, B 51/54, C 1/14, DR 9/11, donor; A 31/-, B 51/-, C 14/-, DR 8/11). The patient exhibited a high fever, skin rash, and diarrhea, and was diagnosed with acute GVHD based on the blood chimerism test...
August 19, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28830224/testing-ecological-and-universal-models-of-body-shape-and-child-health-using-a-global-sample-of-infants-and-young-children
#19
Craig Hadley, Daniel J Hruschka
AIM: To test whether a risk of child illness is best predicted by deviations from a population-specific growth distribution or a universal growth distribution. SUBJECTS AND METHODS: Child weight for height and child illness data from 433 776 children (1-59 months) from 47 different low and lower income countries are used in regression models to estimate for each country the child basal weight for height. This study assesses the extent to which individuals within populations deviate from their basal slenderness...
August 22, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28827241/assessment-of-healthcare-delivery-in-the-early-management-of-bacterial-meningitis-in-uk-young-infants-an-observational-study
#20
Ifeanyichukwu O Okike, Shamez N Ladhani, Mark Anthony, Nelly Ninis, Paul T Heath
OBJECTIVE: To define early presenting features of bacterial meningitis in young infants in England and to review the adequacy of individual case management as compared with relevant national guidelines and an expert panel review. DESIGN: Retrospective medical case note review and parental recall using standardised questionnaires. SETTING: England and Wales. PARTICIPANTS: Infants aged <90 days with bacterial meningitis diagnosed between July 2010 and July 2013...
August 21, 2017: BMJ Open
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