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https://www.readbyqxmd.com/read/28231007/molecular-dynamics-recrystallization-behavior-and-water-solubility-of-amorphous-anticancer-agent-bicalutamide-and-its-polyvinylpyrrolidone-mixtures
#1
Justyna Szczurek, Marzena Rams-Baron, Justyna Knapik-Kowalczuk, Agata Antosik, Joanna Szafraniec, Witold Jamroz, Mateusz Dulski, Renata Jachowicz, Marian Paluch
In this paper, we investigated the molecular mobility and physical stability of amorphous bicalutamide, a poorly water-soluble drug widely used in prostate cancer treatment. Our broadband dielectric spectroscopy measurements and differential scanning calorimetry studies revealed that amorphous BIC is a moderately fragile material with strong tendency to recrystallize from amorphous state. However, mixing the drug with polymer polyvinylpyrrolidone results in a substantial improvement of physical stability attributed to antiplasticizing effect governing by polymer additive...
February 23, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28229856/-how-to-analyze-periodontal-morphotypes-in-order-to-reduce-the-risk-of-periodontal-recession
#2
Mathilde Jalladaud, Mike Lahmi, Corinne Lallam
INTRODUCTION: The periodontal morphotype is a leading feature to be born in mind during surgical, implant, prosthetic, restorative as well as orthodontic treatment. A fragile morphotype will rapidly trigger severe and worrying clinical repercussions for the patient. MATERIALS AND METHODS: In order to minimize the risks involved, sound knowledge of the different morphotypes and of the techniques for clinically evaluating them is a major requirement. These factors need to be regularly reassessed since morphotypes can vary throughout the course of treatment...
March 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28229177/advanced-glycation-end-product-3-age3-increases-apoptosis-and-the-expression-of-sclerostin-by-stimulating-tgf-%C3%AE-expression-and-secretion-in-osteocyte-like-mlo-y4-a2-cells
#3
Masakazu Notsu, Ippei Kanazawa, Ayumu Takeno, Maki Yokomoto-Umakoshi, Ken-Ichiro Tanaka, Toru Yamaguchi, Toshitsugu Sugimoto
Advanced glycation end products (AGEs) cause bone fragility due to deterioration in bone quality. We previously reported that AGE3 induced apoptosis and inhibited differentiation via increased transforming growth factor (TGF)-β signaling in osteoblastic cells. Additionally, we demonstrated that AGE3 increased apoptosis and sclerostin expression and decreased receptor activator of nuclear factor-κB ligand (RANKL) expression in osteocyte-like cells. However, it remains unclear whether TGF-β signaling is involved in the effects of AGEs on apoptosis and the expression of sclerostin and RANKL in osteocytes...
February 22, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28228975/the-politics-of-global-public-health-in-fragile-states-and-ungoverned-territories
#4
Frederick M Burkle
The reasons for global health crises and how the world responds to them have dramatically changed over the last half century. Increasingly, natural disasters result in failure of public health and security systems leading to preventable conflict, unconventional war and unprecedented population migration. While scientific expertise exists to mitigate these failures in fragile states and ungoverned territories, inactions are mired by the lack of political will, international legal mandates, and capacity to strategically monitor multidisciplinary public health indicator failures...
January 9, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28228781/denosumab-is-really-effective-in-the-treatment-of-osteoporosis-secondary-to-hypogonadism-in-prostate-carcinoma-patients-a-prospective-randomized-multicenter-international-study
#5
Carlo Doria, Paolo Tranquilli Leali, Federico Solla, Gianluca Maestretti, Massimo Balsano, Robero Mario Scarpa
INTRODUCTION: Osteoporosis is a complication of androgen deprivation therapy (ADT) in men with prostate carcinoma. The best defense against osteoporosis in prostate cancer is to identify patients with a high risk for fracture during the first clinical visit, select an effective anti-osteoporosis agent, and advise the patient to change his lifestyle and diet to prevent further bone loss. New agents include denosumab, a human monoclonal antibody that inhibits the RANK ligand (RANKL). RANKL promotes the formation, activity, and survival of osteoclasts and, thus, supports the breakdown of bone...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28228533/fragile-phagocytes-fmrp-positively-regulates-engulfment-activity
#6
Mary A Logan
Defective immune system function is implicated in autism spectrum disorders, including Fragile X syndrome. In this issue, O'Connor et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607093) demonstrate that phagocytic activity of systemic immune cells is compromised in a Drosophila melanogaster model of Fragile X, highlighting intriguing new mechanistic connections between FMRP, innate immunity, and abnormal development.
February 22, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28228025/variability-in-the-relaxation-behavior-of-glass-impact-of-thermal-history-fluctuations-and-fragility
#7
Qiuju Zheng, John C Mauro
Glasses are nonequilibrium materials that continuously relax toward the metastable supercooled liquid state. As such, the properties of a glass depend on both its composition and thermal history. When an initially cooled glass is subjected to additional thermal cycles, relaxation during the heat treatment is accelerated, leading to changes in the macroscopic properties of the glass. This relaxation behavior is intrinsic to the glassy state and of critical interest to the high-tech glass industry. In many practical cases, the magnitude of the relaxation is less important than the variability of the relaxation effects due to slight variations in the thermal history experienced by the glass...
February 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28227690/muscle-fiber-excitation-system
#8
Bertram N Ezenwa, Thomas Kernozek, Bertram N Ezenwa, Thomas Kernozek, Thomas Kernozek, Bertram N Ezenwa
Persons unable to exercise due to old age, immobility or medical condition may develop low bone density, decline in muscle contraction, blood pooling or clot. Due to musculoskeletal fragility caution is required in bone and muscle strengthening. Similarly, caution is required to use anticoagulant drug to prevent blood clot due to side effect, and compression devices are not as effective as drug. This paper presents a transcutaneous muscle fiber excitation system adaptable for use in seated, walking or lying position...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227326/detection-of-binaural-interaction-in-free-field-evoked-auditory-brainstem-responses-by-time-scale-representations
#9
Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Horst Hessel, Erik Schebsdat, Harald Seidler, Daniel J Strauss
The so called β-wave of the binaural interaction component (BIC) in auditory brainstem responses (ABR) has been shown to be an objective measure for binaural interaction (BI). This component is the arithmetical difference between the sum of the monaurally evoked ABRs and the binaurally evoked ABR. Unfortunately, these neural responses are known to be very fragile and as a result the calculated BIC. An additional issue is, that the findings of this measurement are predominantly needed in people with hearing loss who may use hearing devices like hearing aids (HA) or cochlear implants (CI), thus they are not able to use headphones (like in conventional ABR measurements) during the detection of possible BI...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226890/stability-of-the-microdroplets-for-portable-biosensor
#10
Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki
This paper highlights the behavior of microdroplets used for portable biosensors. Microdroplets have been applied for various Lab-on-a-chip applications, in which portability/wearable is becoming a trend word. However, the resonance (sloshing phenomena) of the microdroplets could be an issue. For example, bilayer lipid membrane, fragile characteristics due to its thickness of 5 nm, easily ruptures by jiggling. We therefore prepared various dimensions of droplets by changing the well shape, and examined the resulting waves depending on the vibration frequency between 20 and 100 Hz, including daily life frequencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226747/automatic-detection-of-neovascularization-on-optic-disk-region-with-feature-extraction-and-support-vector-machine
#11
Shuang Yu, Di Xiao, Yogesan Kanagasingam, Shuang Yu, Di Xiao, Yogesan Kanagasingam, Di Xiao, Yogesan Kanagasingam, Shuang Yu
Neovascularization (NV) is a definitive indicator for the onset of Proliferative Diabetic Retinopathy (PDR). The new vessels are fragile and prone to bleed, leading to high risk of sudden vision loss. Automatic detection of NV is an important task in automatic Diabetic Retinopathy (DR) screening as a consequence of the unmet requirement between the growing number of DR patients and limited number of ophthalmologists. This paper focuses on the computer aided detection of neovascularization in the optic disk region...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226719/a-new-hybrid-watermarking-algorithm-for-mri-medical-images-using-dwt-and-hash-functions
#12
F Taher, A Kunhu, H AlAhmad, F Taher, A Kunhu, H AlAhmad, H AlAhmad, A Kunhu, F Taher
This paper deals with a blind hybrid digital watermarking algorithm for the copyright protection and authentication of magnetic resonance tomography images. Medical image watermarking requires extreme care when embedding watermark information in the medical images, to protect the image quality from being violated and to avoid the wrong diagnosis that might occur. The proposed algorithm contains robust watermark for the ownership protection and fragile watermarks for checking the authenticity. In the proposed algorithm, the medical image is divided into two regions, called the Region of Interest and Region of Non-Interest using histogram technique and the watermarks are embedded in both wavelet domain and spatial domain in the Region of Non-Interest Area...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226675/bone-texture-characterization-for-osteoporosis-diagnosis-using-digital-radiography
#13
Keni Zheng, Sokratis Makrogiannis, Keni Zheng, Sokratis Makrogiannis, Sokratis Makrogiannis, Keni Zheng
We introduce texture classification techniques to effectively diagnose osteoporosis in bone radiography data. Osteoporosis is an age-related systemic bone skeletal disorder characterized by low bone mass and bone structure deterioriation that results in increased bone fragility and higher fracture risk. Therefore, early diagnosis can effectively predict fracture risk and prevent the disease. Automated diagnosis from digital radiographs is very challenging since the scans of healthy and osteoporotic subjects show little or no visual differences, and their density histograms mostly overlap...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223919/commentary-depletion-of-the-fragile-x-mental-retardation-protein-in-embryonic-stem-cells-alters-the-kinetics-of-neurogenesis
#14
COMMENT
Cara J Westmark
No abstract text is available yet for this article.
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28223372/perspectives-of-low-socioeconomic-status-mothers-of-premature-infants
#15
Elizabeth Enlow, Laura J Faherty, Sara Wallace-Keeshen, Ashley E Martin, Judy A Shea, Scott A Lorch
BACKGROUND AND OBJECTIVES: Transitioning premature infants from the NICU to home is a high-risk period with potential for compromised care. Parental stress is high, and families of low socioeconomic status may face additional challenges. Home visiting programs have been used to help this transition, with mixed success. We sought to understand the experiences of at-risk families during this transition to inform interventions. METHODS: Mothers of infants born at <35 weeks' gestation, meeting low socioeconomic status criteria, were interviewed by telephone 30 days after discharge to assess caregiver experiences of discharge and perceptions of home visitors (HVs)...
February 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/28223318/a-drosophila-model-of-fragile-x-syndrome-exhibits-defects-in-phagocytosis-by-innate-immune-cells
#16
Reed M O'Connor, Elizabeth F Stone, Charlotte R Wayne, Emily V Marcinkevicius, Matt Ulgherait, Rebecca Delventhal, Meghan M Pantalia, Vanessa M Hill, Clarice G Zhou, Sophie McAllister, Anna Chen, Jennifer S Ziegenfuss, Wesley B Grueber, Julie C Canman, Mimi M Shirasu-Hiza
Fragile X syndrome, the most common known monogenic cause of autism, results from the loss of FMR1, a conserved, ubiquitously expressed RNA-binding protein. Recent evidence suggests that Fragile X syndrome and other types of autism are associated with immune system defects. We found that Drosophila melanogaster Fmr1 mutants exhibit increased sensitivity to bacterial infection and decreased phagocytosis of bacteria by systemic immune cells. Using tissue-specific RNAi-mediated knockdown, we showed that Fmr1 plays a cell-autonomous role in the phagocytosis of bacteria...
February 21, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28222716/assessing-the-feasibility-of-introducing-health-insurance-in-afghanistan-a-qualitative-stakeholder-analysis
#17
Wu Zeng, Christine Kim, Lauren Archer, Omarzaman Sayedi, Mohammad Yousuf Jabarkhil, Kathleen Sears
BACKGROUND: In the last decade, the health status of Afghans has improved drastically. However, the health financing system in Afghanistan remains fragile due to high out-of-pocket spending and reliance on donor funding. To address the country's health financing challenges, the Ministry of Public Health investigated health insurance as a mechanism to mobilize resources for health. This paper presents stakeholders' opinions on seven preconditions of implementing this approach, as their understanding and buy-in to such an approach will determine its success...
February 22, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28222427/impact-of-fmr1-pre-mutation-status-on-blastocyst-development-in-patients-undergoing-pre-implantation-genetic-diagnosis
#18
Anne P Hutchinson, Nigel Pereira, Debra P Lilienthal, Siobhán Coveney, Jovana P Lekovich, Rony T Elias, Zev Rosenwaks
BACKGROUND/AIMS: The study aimed to investigate the impact of fragile X mental retardation 1 (FMR1) pre-mutation status on blastocyst development in patients undergoing pre-implantation genetic diagnosis (PGD). METHODS: Case-control study of patients <40 years undergoing PGD at blastocyst stage for FMR1 pre-mutation status. Age-matched patients undergoing PGD for other single gene disorders were considered controls. Blastocyst development, calculated per metaphase II (MII) oocyte retrieved and per 2 pronuclear (2PN) embryos, was compared between the 2 groups...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28220607/neurological-and-spinal-manifestations-of-the-ehlers-danlos-syndromes
#19
Fraser C Henderson, Claudiu Austin, Edward Benzel, Paolo Bolognese, Richard Ellenbogen, Clair A Francomano, Candace Ireton, Petra Klinge, Myles Koby, Donlin Long, Sunil Patel, Eric L Singman, Nicol C Voermans
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves. Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression...
February 21, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28219953/function-of-the-arabidopsis-kinesin-4-fra1-requires-abundant-processive-motility
#20
Anindya Ganguly, Logan DeMott, Ram Dixit
Processivity is important for kinesins that mediate intracellular transport. Structure-function analyses of N-terminal kinesins have identified several non-motor regions that affect processivity in vitro However, whether these structural elements affect kinesin processivity and function in vivo is not known. Here, we used an Arabidopsis kinesin-4, called Fragile Fiber1 (FRA1), which is thought to mediate vesicle transport to test whether mutations that alter processivity in vitro behave similarly in vivo and whether processivity is important for FRA1's function...
February 20, 2017: Journal of Cell Science
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