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https://www.readbyqxmd.com/read/29912877/low-cost-three-dimensional-printed-phantom-for-neuraxial-anesthesia-training-development-and-comparison-to-a-commercial-model
#1
Azad Mashari, Mario Montealegre-Gallegos, Jelliffe Jeganathan, Lu Yeh, Joshua Qua Hiansen, Massimiliano Meineri, Feroze Mahmood, Robina Matyal
METHODS: Anonymized CT DICOM data was segmented to create a 3D model of the lumbar spine. The 3D model was modified, placed inside a digitally designed housing unit and fabricated on a desktop 3D printer using polylactic acid (PLA) filament. The model was filled with an echogenic solution of gelatin with psyllium fiber. Twenty-two staff anesthesiologists performed a spinal and epidural on the 3D printed simulator and a commercially available Simulab phantom. Participants evaluated the tactile and ultrasound imaging fidelity of both phantoms via Likert-scale questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29912659/adolescents-perspectives-on-everyday-life-with-obesity-a-qualitative-study
#2
Gudbjørg Øen, Bente Kvilhaugsvik, Kari Eldal, Anne-Grethe Halding
PURPOSE: This study aimed to gain an in-depth understanding of the perspectives and life experiences of adolescents living with obesity. METHODS: Five adolescents living with obesity were involved in repeated interviews, and qualitative content analysis was performed. RESULTS: Three themes emerged: obesity as a multi-faceted and difficult to solve condition; obesity as a shameful and vulnerable subject; and bullying and fragile social relationships...
December 2018: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29912083/caring-for-pediatric-patients-with-epidermolysis-bullosa-in-the-emergency-department
#3
Helena A Jenkinson, Ashley D Lundgren, Moise L Levy, Lucia Z Diaz
Epidermolysis bullosa (EB) refers to a heterogeneous group of genetic disorders characterized by epithelial fragility. We provide guidelines for management of pediatric patients with EB in the emergency department based on a review of literature, as well as insights from our own experiences caring for patients with EB. The purpose of the guidelines proposed is prevention of avoidable iatrogenic trauma to the skin and mucosa of patients with EB who are presenting to the emergency department for a variety of reasons...
June 14, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29911483/characterization-and-prevalence-of-elder-abuse-in-brazil
#4
Flaviano da Silva Santos, Maria Vieira de Lima Saintrain, Luiza Jane Eyre de Souza Vieira, Edgar Gomes Marques Sampaio
We aimed to assess the prevalence and characterize the profile of elder abuse in Brazil in this quantitative descriptive and exploratory study using a document analysis of cases of elder abuse against people aged 60 and over reported to Brazil's Notifiable Disease Information System ( Sistema de Informação de Agravos de Notificação-SINAN) from 2009 to 2013. Association between age groups (older adults and non-older adults) and (a) characteristics of the victims (gender, age, and race), (b) characteristics of the violence (type of violence, place of occurrence, and repeated violence) and, (c) characteristics of the perpetrator (gender, suspected alcohol consumption, and victim-perpetrator relationship) were assessed using the chi-square test and odds ratios (OR) with a 95% confidence interval...
June 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29910019/epigenetic-editing-repurposing-for-rescue
#5
Hari R Singh
The epigenome editing framework provides an engineering approach to explore chromatin-based gene expression mechanisms. However, therapeutic utility of epigenetic editing-based systems has been lacking. A report in Cell (Liu et. al., 2018) shows that epigenetic editors can revert abnormal heterochromatin formation at the gene promoter leading to restoration of FMR1 gene expression, functionally rescuing fragile X syndrome (FXS), an otherwise unamenable genetic disorder.
June 14, 2018: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/29909596/osteogenesis-imperfecta-muscle-bone-interactions-when-bi-directionally-compromised
#6
REVIEW
Charlotte L Phillips, Youngjae Jeong
PURPOSE OF REVIEW: Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder of skeletal fragility and more recently muscle weakness. This review highlights our current knowledge of the impact of compromised OI muscle function on muscle-bone interactions and skeletal strength in OI. RECENT FINDINGS: The ramifications of inherent muscle weakness in OI muscle-bone interactions are just beginning to be elucidated. Studies in patients and in OI mouse models implicate altered mechanosensing, energy metabolism, mitochondrial dysfunction, and paracrine/endocrine crosstalk in the pathogenesis of OI...
June 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29909210/synchronous-diagnosis-of-intradiploic-epidermoid-cyst-and-anatomically-close-associated-chronic-epidural-hematoma
#7
Jian Zheng, Hong Zhang, Chun Wang
BACKGROUND: Intradiploic epidermoid cyst (IEC) concurrent with chronic epidural hematoma (CEDH) has never been reported in the literature. We report a unique case of IEC concurrent with anatomically close associated CEDH. CASE DESCRIPTION: A 54-year-old man presented with one week history of headache, confusion and drowsiness. Computed tomography (CT) exposed large extraaxial mixed density lesions with bone destruction and substantial mass effect in the left fronto-temporal region...
June 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29908901/neonatal-rbc-transfusions-do-benefits-outweigh-risks
#8
REVIEW
Iman F Iskander, Khaled M Salama, Rasha M Gamaleldin, Jerard Seghatchian
Preterm neonates represent one of the most transfused categories of patients. Their target hematocrits, however, are mainly based on expert opinion. The risk of transfusions are very high in the smallest preterm baby with a weak immune response, immature antioxidant ability, fragile germinal matrix and impaired cerebral autoregulation, yet red cell transfusions remain the only life saving measure in the baby with symptomatic anemia. Minimizing phlebotomy losses, following a restrictive transfusion policy and using screened, leukocyte depleted, irradiated, single donor blood remain the best means of avoiding the possible risks while maximizing the benefits of red cell transfusions in the preterm newborn...
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29908226/visfatin-alters-the-cytokine-and-matrix-degrading-enzyme-profile-during-osteogenic-and-adipogenic-msc-differentiation
#9
Lali Tsiklauri, Janina Werner, Marian Kampschulte, Klaus W Frommer, Lucija Berninger, Martina Irrgang, Kristina Glenske, Dirk Hose, Thaqif El Khassawna, Jörn Pons-Kühnemann, Stefan Rehart, Sabine Wenisch, Ulf Müller-Ladner, Elena Neumann
OBJECTIVES: Age-related bone loss is associated with bone marrow adiposity. Adipokines (e.g. visfatin, resistin, leptin) are adipocyte-derived factors with immunomodulatory properties and might influence differentiation of bone marrow-derived mesenchymal stem cells (MSC) in osteoarthritis (OA) and osteoporosis. Thus, the presence of adipokines and MMPs in bone marrow and their effects on MSC differentiation were analyzed. METHODS: MSC and RNA were isolated from femoral heads after hip replacement surgery of OA or osteoporotic femoral neck fracture (FF) patients...
June 13, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29907046/high-density-liquid-structure-enhancement-in-glass-forming-aqueous-solution-of-licl
#10
G Camisasca, M De Marzio, M Rovere, P Gallo
We investigate using molecular dynamics simulations the dynamical and structural properties of LiCl:6H2 O aqueous solution upon supercooling. This ionic solution is a glass forming liquid of relevant interest in connection with the study of the anomalies of supercooled water. The LiCl:6H2 O solution is easily supercooled and the liquid state can be maintained over a large decreasing temperature range. We performed simulations from ambient to 200 K in order to investigate how the presence of the salt modifies the behavior of supercooled water...
June 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29906456/reward-circuitry-activation-reflects-social-preferences-in-the-face-of-cognitive-effort
#11
Holly Sullivan-Toole, Ekaterina Dobryakova, Samantha DePasque, Elizabeth Tricomi
Research at the intersection of social neuroscience and cognitive effort is an interesting new area for exploration. There is great potential to broaden our understanding of how social context and cognitive effort processes, currently addressed in disparate literatures, interact with one another. In this paper, we briefly review the literature on cognitive effort, focusing on effort-linked valuation and the gap in the literature regarding cognitive effort in the social domain. Next, we present a study designed to explore valuation processes linked to cognitive effort within the social context of an inequality manipulation...
June 12, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29906197/mobiderm-autofit-an-adjustable-sleeve-that-enables-patients-to-self-manage-lymphoedema
#12
Marie Todd, Charlotte Stubbs, Stacy Pugh
Lymphoedema can result in debilitating physical and psychosocial morbidity and when combined with other chronic comorbidity, often requires holistic, specialist management that encompasses all the complex and compounding problems. Self-care is an integral component of any treatment strategy, however, the patient must be fully prepared and ongoing support should be provided. Self-care consists of managing the symptoms of lymphoedema but should include other fundamental aspects of healthy living, for example, maintaining a healthy weight and activity levels...
April 1, 2018: British Journal of Community Nursing
https://www.readbyqxmd.com/read/29905781/association-between-genomic-instability-and-evolutionary-chromosomal-rearrangements-in-neotropical-primates
#13
Fiona Puntieri, Nancy B Andrioli, Mariela Nieves
During the last decades the mammalian genome has been proposed to have regions prone to breakage and reorganization concentrated in certain chromosomal bands that seem to correspond to evolutionary breakpoints. These bands are likely to be involved in chromosome fragility or instability. In Primates, some biomarkers of genetic damage may be associated with various degrees of genomic instability. Here, we investigated the usefulness of Sister Chromatid Exchange (SCE) as a biomarker of potential sites of frequent chromosome breakage and rearrangement in Alouatta caraya, Ateles chamek, Ateles paniscus and Cebus cay...
June 14, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#14
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904720/rare-variants-and-de-novo-variants-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#15
John K L Wong, Hongsheng Gui, Maxwell Kwok, Ping Wing Ng, Colin H T Lui, Larry Baum, Pak Chung Sham, Patrick Kwan, Stacey S Cherny
Objective: We investigated the role of rare genetic variants and of de novo variants in the pathogenesis of mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). Methods: Whole-exome sequencing (WES) was performed in patients with MTLE-HS and their unaffected parents (trios). Genes or gene sets that were enriched with predicted damaging rare variants in the patients as compared to population controls were identified. Patients and their parents were compared to identify whether the variants were de novo or inherited...
June 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29903667/-the-most-common-stopp-start-criteria-in-spain-a-review-of-the-literature
#16
Esther Salgueiro, Bryana Candelaria Elizarde, Ana Isabel Elola, Beatriz García-Pulido, María Luisa Nicieza-García, Gloria Manso
OBJECTIVE: To analyse STOPP/START criteria found most frequently in the studies carried out in Spain, in order to identify the main areas of potentially inappropriate prescribing. METHODS: A literature review was carried out on the original studies performed in Spain that applied the original version of the STOPP/START criteria and that described the most common STOPP and/or START criteria found. In each study, a weighted analysis was performed on the criteria found, by assigning 5 points to the criterion in first position, 4 points to the criterion in second position, and so on to fifth criterion...
June 11, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29902622/detection-of-sand-encroachment-patterns-in-desert-oases-the-case-of-erg-chebbi-morocco
#17
Arnald Puy, Manuel Herzog, Pedro Escriche, Amou Marouche, Yousef Oubana, Olaf Bubenzer
Desert oases are fragile agrarian areas, very vulnerable to sand encroachment by wind. Ensuring their conservation highly depends on our capacity to identify sand encroachment patterns, e.g. the origin of sand and its spatial distribution in the irrigated plots. Here we show how to tackle this issue using the case study of Erg Chebbi (Morocco), where two oases (Hassilabiad and Merzouga) are surrounded by dunes, Hamada and alluvial sediments from the Wadi Ziz. We combine field interviews with the study of wind dynamics, sediment sampling, Particle Size Distribution (PSD) tests and End-Member Modelling Analysis (EMMA)...
June 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29902593/bone-matrix-development-in-steroid-induced-osteoporosis-is-associated-with-a-consistently-reduced-fibrillar-stiffness-linked-to-altered-bone-mineral-quality
#18
L Xi, P De Falco, E Barbieri, A Karunaratne, L Bentley, C T Esapa, N J Terrill, S D M Brown, R D Cox, G R Davis, N M Pugno, R V Thakker, H S Gupta
Glucocorticoid-induced osteoporosis (GIOP) is a major secondary form of osteoporosis, with the fracture risk significantly elevated - at similar levels of bone mineral density - in patients taking glucocorticoids compared with non-users. The adverse bone structural changes at multiple hierarchical levels in GIOP, and their mechanistic consequences leading to reduced load-bearing capacity, are not clearly understood. Here we combine experimental X-ray nanoscale mechanical imaging with analytical modelling of the bone matrix mechanics to determine mechanisms causing bone material quality deterioration during development of GIOP...
June 11, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29902195/theoretical-open-loop-model-of-respiratory-mechanics-in-the-extremely-preterm-infant
#19
Laura Ellwein Fix, Joseph Khoury, Russell R Moores, Lauren Linkous, Matthew Brandes, Henry J Rozycki
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to their markedly increased chest wall compliance that does not provide enough structure against which the forces of inhalation can generate sufficient pressure. To address the continued challenge of studying treatments in this fragile population, we developed a nonlinear lumped-parameter respiratory system mechanics model of the extremely preterm infant that incorporates nonlinear lung and chest wall compliances and lung volume parameters tuned to this population...
2018: PloS One
https://www.readbyqxmd.com/read/29901787/dysfunctional-autism-risk-genes-cause-circuit-specific-connectivity-deficits-with-distinct-developmental-trajectories
#20
Valerio Zerbi, Giovanna D Ielacqua, Marija Markicevic, Matthias Georg Haberl, Mark H Ellisman, Arjun A-Bhaskaran, Andreas Frick, Markus Rudin, Nicole Wenderoth
Autism spectrum disorders (ASD) are a set of complex neurodevelopmental disorders for which there is currently no targeted therapeutic approach. It is thought that alterations of genes regulating migration and synapse formation during development affect neural circuit formation and result in aberrant connectivity within distinct circuits that underlie abnormal behaviors. However, it is unknown whether deviant developmental trajectories are circuit-specific for a given autism risk-gene. We used MRI to probe changes in functional and structural connectivity from childhood to adulthood in Fragile-X (Fmr1-/y) and contactin-associated (CNTNAP2-/-) knockout mice...
July 1, 2018: Cerebral Cortex
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