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https://www.readbyqxmd.com/read/29684108/pituitary-diseases-and-bone
#1
Gherardo Mazziotti, Stefano Frara, Andrea Giustina
Neuroendocrinology of bone is a new area of research based on the evidence that pituitary hormones may directly modulate bone remodeling and metabolism. Skeletal fragility associated with high risk of fractures is a common complication of several pituitary diseases such as hypopituitarism, Cushing disease, acromegaly and hyperprolactinemia. As in other forms of secondary osteoporosis, pituitary diseases generally affect bone quality more than bone quantity and fractures may occur even in the presence of normal or low-normal bone mineral density as measured by dual-energy X-ray absorptiometry, making difficult the prediction of fractures in these clinical settings...
April 19, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29683494/the-fragility-of-statistically-significant-findings-from-randomized-trials-in-head-and-neck-surgery
#2
Christopher W Noel, Caitlin McMullen, Christopher Yao, Eric Monteiro, David P Goldstein, Antoine Eskander, John R de Almeida
OBJECTIVES: The Fragility Index (FI) is a novel tool for evaluating the robustness of statistically significant findings in a randomized control trial (RCT). It measures the number of events upon which statistical significance depends. We sought to calculate the FI scores for RCTs in the head and neck cancer literature where surgery was a primary intervention. DATA SOURCES: Potential articles were identified in PubMed (MEDLINE), Embase, and Cochrane without publication date restrictions...
April 23, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29683422/corrigendum-a-systematic-review-and-economic-evaluation-of-bisphosphonates-for-the-prevention-of-fragility-fractures
#3
Sarah Davis, Marrissa Martyn-St James, Jean Sanderson, John Stevens, Edward Goka, Andrew Rawdin, Susi Sadler, Ruth Wong, Fiona Campbell, Matt Stevenson, Mark Strong, Peter Selby, Neil Gittoes
No abstract text is available yet for this article.
March 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29683194/clinical-experience-with-multigene-carrier-panels-in-the-reproductive-setting
#4
Catherine Terhaar, Nicole Teed, Rachel Allen, Lindsay Dohany, Christina Settler, Carol Holland, Ryan E Longman
OBJECTIVES: Expanded carrier testing is acknowledged as an acceptable strategy for carrier testing by the American College of Obstetrics and Gynecology. Limited studies have investigated positivity rates of expanded carrier panels. We describe our experience with three commercial laboratory panels varying in size from 3 to 218 disorders. METHODS: We reviewed outcomes for three multigene carrier screening panels: Trio (3 diseases), Standard (23 diseases), and Global (218 diseases)...
April 23, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29683100/pioglitazone-therapy-and-fractures-systematic-review-and-meta-analysis
#5
Velichka Pavlova, Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
INTRODUCTION: Thiazolidinediones are group of synthetic medications used in type 2 diabetes treatment. Among available thiazolidinediones pioglitazone is gaining increased attention due to its lower cardiovascular risk in type 2 diabetes mellitus sufferers and seems a promising future therapy. Accumulating evidence suggests that diabetic patients may exert bone fractures due to such treatments. Simultaneously, female population is thought to be at greater risk. Still the safety outcomes of pioglitazone treatment especially in terms of fractures are questionable and need to be clarified...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29682316/physical-properties-of-the-tunic-in-the-pinkish-brown-salp-pegea-confoederata-tunicata-thaliacea
#6
Daisuke Sakai, Hiroshi Kakiuchida, Jun Nishikawa, Euichi Hirose
Background: Invisibility in the water column is a crucial strategy for gelatinous zooplanktons in avoiding detection by visual predators, especially for animals distributed in the euphotic zone during the daytime; i.e., surface dwellers that do not undergo diel vertical migration. Salps, a member of the subphylum Tunicata (Urochordata), usually have a transparent body that is entirely covered with a cellulosic matrix, called the tunic. Some non-migrator species are known to exhibit a nano-scale nipple array on the tunic surface...
2018: Zoological Letters
https://www.readbyqxmd.com/read/29682283/the-role-of-ckip-1-in-osteoporosis-development-and-treatment
#7
X Peng, X Wu, J Zhang, G Zhang, G Li, X Pan
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29681800/early-retinal-defects-in-fmr1-y-mice-toward-a-critical-role-of-visual-dys-sensitivity-in-the-fragile-x-syndrome-phenotype
#8
Olivier Perche, Chloé Felgerolle, Maryvonne Ardourel, Audrey Bazinet, Arnaud Pâris, Rafaëlle Rossignol, Géraldine Meyer-Dilhet, Anne-Laure Mausset-Bonnefont, Betty Hébert, David Laurenceau, Céline Montécot-Dubourg, Arnaud Menuet, Jean-Charles Bizot, Jacques Pichon, Isabelle Ranchon-Cole, Sylvain Briault
Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we recently demonstrated that retinas of adult Fmr1 -/y mice, the FXS murine model, present molecular, cellular and functional alterations. However, no data are currently available on the evolution pattern of such defects...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29681582/subchondral-insufficiency-fracture-of-the-femoral-head-in-a-pregnant-woman-with-pre-existing-anorexia-nervosa
#9
Kyoko Kasahara, Tomohiro Mimura, Suzuko Moritani, Taku Kawasaki, Shinji Imai, Shunichiro Tsuji, Fuminori Kimura, Takashi Murakami
Subchondral insufficiency fracture (SIF) is a fragility fracture secondary to osteoporosis that leads to collapse of the femoral head with no evidence of osteonecrosis. SIF of the femoral head has been reported in adults of varying ages and both sexes, but it has never been reported to occur in pregnant women. Herein, we describe a 40-year-old primiparous patient with pre-existing anorexia nervosa who developed SIF of the femoral head in the third trimester. At 29 weeks of gestation, the patient complained of sudden pain on walking in both hips...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29681292/a-fragility-index-handle-with-care
#10
EDITORIAL
Travis C Porco, Thomas M Lietman
No abstract text is available yet for this article.
May 2018: Ophthalmology
https://www.readbyqxmd.com/read/29680134/-consent-in-everyday-medicine
#11
Olivier Lesieur
In its legal sense, the term 'consent' finalises an agreement between two parties. When the care relationship is a long-term process, consent becomes a dynamic interaction between patient and caregivers, resulting in a fragile compromise which is continuously being brought into question by the unpredictable nature of the illness. Based on a holistic approach to the concept of autonomy, the decision-making process should take into account both the rationality of the deliberation and the individual's specific preferences...
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29679732/inter-site-variability-of-the-osteocyte-lacunar-network-in-the-cortical-bone-underpins-fracture-susceptibility-of-the-superolateral-femoral-neck
#12
Tim Rolvien, Annika Vom Scheidt, Kilian Stockhausen, Petar Milovanovic, Danijela Djonic, Jan Hubert, Thelonius Hawellek, Alexander Wacker, Volker Jebens, Klaus Püschel, Elizabeth A Zimmermann, Marija Djuric, Michael Amling, Björn Busse
BACKGROUND: The osteocytic lacunar network is considered to be an integral player in the regulation of bone homeostasis, and reduction in osteocytes is associated with reduced bone strength. Here, we analyzed site-specific patterns in osteocyte characteristics and matrix composition in the cortical compartment of the femoral neck to reveal structural basis of its fragility. METHODS: Cross-sections of the human femoral neck - one of the most common fracture sites - were acquired from 12 female cadavers (age 34-86 years) and analyzed with backscattered scanning electron microscopy and high-resolution micro-computed tomography (μ-CT)...
April 18, 2018: Bone
https://www.readbyqxmd.com/read/29679717/stat-3-regulation-of-cxcr4-is-necessary-for-the-prenylflavonoid-icaritin-to-enhance-mesenchymal-stem-cell-proliferation-migration-and-osteogenic-differentiation
#13
R Z L Lim, L Li, E L Yong, N Chew
Mesenchymal stem cell (MSC) dysfunction has been implicated in the pathogenesis of osteoporosis. MSCs derived from osteoporotic subjects demonstrate significant impairment in proliferation, adhesion and chemotaxis, and osteogenic differentiation, leading to reduced functional bone-forming osteoblasts and ultimately nett bone loss and osteoporosis. Epimedium herbs and its active compound Icaritin (ICT) have been used in Chinese ethnopharmacology for the treatment of metabolic bone diseases. Using an in-vitro cell culture model, we investigated the benefits of ICT treatment in enhancing MSC proliferation, migration and osteogenic differentiation, and provide novel data to describe its mechanism of action...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29679399/inherited-epidermolysis-bullosa-new-diagnostics-and-new-clinical-phenotypes
#14
Cristina Has, Judith Fischer
Inherited epidermolysis bullosa (EB) is a group of heterogeneous genetic disorders characterized by skin fragility. EB comprises a large spectrum of phenotypes, ranging from severe cutaneous and extracutaneous involvement caused by lack of key adhesion proteins, to mild cutaneous fragility caused by subtle molecular defects. Disease-causing variants in 20 different genes account for the genetic and allelic heterogeneity of EB. Here we discuss the development of laboratory methods that enabled these discoveries and the clinical and molecular features of some new EB entities elucidated during the past 5-6 years...
April 20, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29679286/fast-eruption-desorption-ionization-for-mass-spectrometric-analysis
#15
Xiao-Pan Liu, Hao-Yang Wang, Guo-Qing Dong, Zhong-Quan Li, Yin-Long Guo
Fast eruption desorption ionization (FEDI) technique was developed for simple, rapid, and sensitive analysis of various compounds. The FEDI allows three analytical modes each with the unique characteristic. The results demonstrated that non-assisted eruption was suitable for stable and volatile compounds, energetic material (EM)-assisted for nonvolatile molecules especially metal compounds, and solvent-assisted eruption for fragile molecules. High-quality mass spectra with intact ions of analytes were obtained in positive and negative ion modes...
April 20, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29678691/seven-rules-to-avoid-the-tragedy-of-the-commons
#16
Yohsuke Murase, Seung Ki Baek
Cooperation among self-interested players in a social dilemma is fragile and easily interrupted by mistakes. In this work, we study the repeated n-person public-goods game and search for a strategy that forms a cooperative Nash equilibrium in the presence of implementation error with a guarantee that the resulting payoff will be no less than any of the co-players'. By enumerating strategic possibilities for n=3, we show that such a strategy indeed exists when its memory length m equals three. It means that a deterministic strategy can be publicly employed to stabilize cooperation against error with avoiding the risk of being exploited...
April 17, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29678689/using-high-resolution-x-ray-computed-tomography-to-create-an-image-based-model-of-a-lymph-node
#17
L J Cooper, B Zeller-Plumhoff, G F Clough, B Ganapathisubramani, T Roose
Lymph nodes are an important part of the immune system. They filter the lymphatic fluid as it is transported from the tissues before being returned to the blood stream. The fluid flow through the nodes influences the behaviour of the immune cells that gather within the nodes and the structure of the node itself. Measuring the fluid flow in lymph nodes experimentally is challenging due to their small size and fragility. In this paper, we present high resolution X-ray computed tomography images of a murine lymph node...
April 17, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29678139/pulmonary-hemosiderosis-in-children-with-down-syndrome-a-national-experience
#18
Aurelia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera, Pierrick Cros, Isabelle Gibertini, Jocelyne Derelle, Antoine Deschildre, Caroline Thumerelle, Ralph Epaud, Philippe Reix, Michael Fayon, Sylvie Roullaud, Françoise Troussier, Marie-Catherine Renoux, Jacques de Blic, Sophie Leyronnas, Guillaume Thouvenin, Caroline Perisson, Aimé Ravel, Annick Clement, Harriet Corvol, Nadia Nathan
BACKGROUND: Pulmonary hemosiderosis is a rare and complex disease in children. A previous study from the French RespiRare® network led to two important findings: 20% of the children presented with both pulmonary hemosiderosis and Down syndrome (DS), and at least one tested autoantibody was found positive in 50%. This study investigates the relationships between pulmonary hemosiderosis and DS. METHODS: Patients younger than 20 years old and followed for pulmonary hemosiderosis were retrieved from the RespiRare® database...
April 20, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29677202/%C3%AE-1-integrins-mediate-the-bmp2-dependent-transcriptional-control-of-osteoblast-differentiation-and-osteogenesis
#19
Molly Brunner, Noémie Mandier, Thierry Gautier, Genevieve Chevalier, Anne-Sophie Ribba, Philippe Guardiola, Marc R Block, Daniel Bouvard
Osteoblast differentiation is a highly regulated process that requires coordinated information from both soluble factors and the extracellular matrix. Among these extracellular stimuli, chemical and physical properties of the matrix are sensed through cell surface receptors such as integrins and transmitted into the nucleus to drive specific gene expression. Here, we showed that the conditional deletion of β1 integrins in the osteo-precursor population severely impacts bone formation and homeostasis both in vivo and in vitro...
2018: PloS One
https://www.readbyqxmd.com/read/29677054/effects-of-acute-aerobic-exercise-on-arterial-stiffness-and-cerebrovascular-pulsatility-in-adults-with-and-without-hypertension
#20
Wesley K Lefferts, Jacob P DeBlois, Candace N Receno, Tiago V Barreira, Tom D Brutsaert, Robert L Carhart, Kevin S Heffernan
OBJECTIVES: Stiffer central arteries, as seen in hypertension (HTN), foster transmission of pulsatile hemodynamics into fragile cerebral vessels. Aerobic exercise is recommended for adults with HTN, but its effects on arterial stiffness and pulsatility in this group are unclear. This study sought to investigate the effect of acute aerobic exercise on arterial stiffness and cerebrovascular pulsatility in 30 adults with treated HTN and 30 age, sex, and BMI-matched adults without HTN (56 ± 6 years, BMI 28...
April 19, 2018: Journal of Hypertension
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