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https://www.readbyqxmd.com/read/29771607/mechanistic-insights-into-the-modulatory-role-of-the-mechanoreflex-on-central-hemodynamics-using-passive-leg-movement-in-humans
#1
Nicholas T Kruse, William E Hughes, Darren P Casey
The aim of this study was to examine the independent contributions of joint range of motion (ROM), muscle fascicle length (MFL) and joint angular velocity on mechanoreceptor mediated central cardiovascular dynamics using passive leg movement (PLM) in humans. Twelve healthy males (age: 23{plus minus}2 yrs, body mass index: 23.7 kg/m2 ) performed continuous PLM at various randomized joint angles ROM (0-50{degree sign} vs. 50-100{degree sign} vs. 0-100{degree sign}) and joint angular velocities ('fast': 200{degree sign}/s vs...
May 17, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29771178/islet-microvasculature-alterations-with-loss-of-beta-cells-in-patients-with-type-1-diabetes
#2
Joseph S Canzano, Lith H Nasif, Elizabeth A Butterworth, Dongtao A Fu, Mark A Atkinson, Martha Campbell-Thompson
Islet microvasculature provides key architectural and functional roles, yet the morphological features of islets from patients with type 1 diabetes are poorly defined. We examined islet and exocrine microvasculature networks by multiplex immunofluorescence imaging of pancreases from organ donors with and without type 1 diabetes ( n=17 and n=16, respectively) and determined vessel diameter, density, and area. We also analyzed these variables in insulin-positive and insulin-negative islets of 7 type 1 diabetes donors...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29760339/the-potential-antifibrotic-impact-of-apocynin-and-alpha-lipoic-acid-in-concanavalin-a-induced-liver-fibrosis-in-rats-role-of-nadph-oxidases-1-and-4
#3
Mostafa R Fayed, Reem N El-Naga, El-Sayed Akool, Ebtehal El-Demerdash
Liver fibrosis results from chronic inflammation that precipitates excessive accumulation of extracellular matrix. Oxidative stress is involved in its pathogenesis. This study aimed to elucidate the potential antifibrotic effect of the NADPH oxidase (NOX) inhibitor, apocynin against concanavalin A (ConA)-induced immunological model of liver fibrosis, and to investigate the ability of the antioxidant, alpha-lipoic acid (α-LA) to potentiate this effect. Rats were treated with apocynin and/or α-LA for six weeks...
2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29757529/fiber-based-scaffolding-techniques-for-tendon-tissue-engineering
#4
REVIEW
Yang Wu, Yi Han, Yoke San Wong, Jerry Ying Hsi Fuh
Tendon refers to a band of tough, regularly arranged and connective tissue connecting muscle and bone, transferring strength from muscle to bone, and enabling articular stability and movement. The limitations of natural tendon grafts motivate the scaffold-based tissue engineering (TE) approaches, which aim to build patient-specific biological substitutes that can repair the damaged or diseased tissues. Advances in engineering and knowledge of chemistry and biology have brought forth numerous fiber-based technologies, including electrospinning, electrohydrodynamic jet printing, electrochemical alignment technique and other fiber-assembly technologies, which enable the fabrication of tendon tissue structure in three-dimension...
May 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29753626/fgf-and-tgf%C3%AE-signaling-link-form-and-function-during-jaw-development-and-evolution
#5
Katherine C Woronowicz, Stephanie E Gline, Safa T Herfat, Aaron J Fields, Richard A Schneider
How does form arise during development and change during evolution? How does form relate to function, and what enables embryonic structures to presage their later use in adults? To address these questions, we leverage the distinct functional morphology of the jaw in duck, chick, and quail. In connection with their specialized mode of feeding, duck develop a secondary cartilage at the tendon insertion of their jaw adductor muscle on the mandible. An equivalent cartilage is absent in chick and quail. We hypothesize that species-specific jaw architecture and mechanical forces promote secondary cartilage in duck through the differential regulation of FGF and TGFβ signaling...
May 10, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29750152/automatic-myotendinous-junction-tracking-in-ultrasound-images-with-phase-based-segmentation
#6
Guang-Quan Zhou, Yi Zhang, Ruo-Li Wang, Ping Zhou, Yong-Ping Zheng, Olga Tarassova, Anton Arndt, Qiang Chen
Displacement of the myotendinous junction (MTJ) obtained by ultrasound imaging is crucial to quantify the interactive length changes of muscles and tendons for understanding the mechanics and pathological conditions of the muscle-tendon unit during motion. However, the lack of a reliable automatic measurement method restricts its application in human motion analysis. This paper presents an automated measurement of MTJ displacement using prior knowledge on tendinous tissues and MTJ, precluding the influence of nontendinous components on the estimation of MTJ displacement...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29743679/control-of-cardiac-jelly-dynamics-by-notch1-and-nrg1-defines-the-building-plan-for-trabeculation
#7
Gonzalo Del Monte-Nieto, Mirana Ramialison, Arne A S Adam, Bingruo Wu, Alla Aharonov, Gabriele D'Uva, Lauren M Bourke, Mara E Pitulescu, Hanying Chen, José Luis de la Pompa, Weinian Shou, Ralf H Adams, Sarah K Harten, Eldad Tzahor, Bin Zhou, Richard P Harvey
In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like network of cardiomyocytes that is critical for contraction and conduction, ventricular septation, papillary muscle formation and wall thickening through the process of compaction 1 . Defective trabeculation leads to embryonic lethality2-4 or non-compaction cardiomyopathy (NCC) 5 . There are divergent views on when and how trabeculation is initiated in different species. In zebrafish, trabecular cardiomyocytes extrude from compact myocardium 6 , whereas in chicks, chamber wall thickening occurs before overt trabeculation 7 ...
May 9, 2018: Nature
https://www.readbyqxmd.com/read/29743109/muscle-and-tendon-morphology-alterations-in-children-and-adolescents-with-mild-forms-of-spastic-cerebral-palsy
#8
Annika Kruse, Christian Schranz, Markus Tilp, Martin Svehlik
BACKGROUND: Early detection of changes at the muscular level before a contracture develops is important to gain knowledge about the development of deformities in individuals with spasticity. However, little information is available about muscle morphology in children with spastic diplegic cerebral palsy (CP) without contracture or equinus gait. Therefore, the aim of this study was to compare the gastrocnemius medialis (GM) and Achilles tendon architecture of children and adolescents with spastic CP without contracture or equinus gait to that of typically developing (TD) children...
May 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29740320/amifostine-analog-drde-30-attenuates-bleomycin-induced-pulmonary-fibrosis-in-mice
#9
Aastha Arora, Vikas Bhuria, Puja P Hazari, Uma Pathak, Sweta Mathur, Bal G Roy, Rajat Sandhir, Ravi Soni, Bilikere S Dwarakanath, Anant N Bhatt
Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from the toxic effects of radiation and BLM, its application is limited due to associated toxicity and unfavorable route of administration. Therefore, there is a need for selective, potent, and safe anti-fibrotic drugs...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29730703/narrowing-of-ischiofemoral-and-quadratus-femoris-spaces-in-pediatric-ischiofemoral-impingement
#10
Shlomit Goldberg-Stein, Avi Friedman, Qi Gao, Jaeun Choi, Jacob Schulz, Eric Fornari, Benjamin Taragin
OBJECTIVE: To correlate MRI findings of quadratus femoris muscle edema (QFME) with narrowing of the ischiofemoral space (IFS) and quadratus femoris space (QFS) in children, and to identify threshold values reflecting an anatomic architecture that may predispose to ischiofemoral impingement. MATERIALS AND METHODS: A case-control retrospective MRI review of 49 hips in 27 children (mean, 13 years) with QFME was compared to 49 hips in 27 gender and age-matched controls...
May 5, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29729220/post-hatching-growth-of-the-pectoralis-muscle-in-pigeon-and-its-functional-implications
#11
Xinxin Liang, Jiali Yu, Huan Wang, Zihui Zhang
The avian pectoralis muscle is responsible for the wing's downstroke, which provides birds with lift and thrust for flight. In the present study, architectural parameters were investigated through growth in the pigeon (Columba livia), an altricial bird species, from the ages of 4 days to 12 months, in order to assess the morphological changes and effects of increasing body mass. Muscle mass, fascicle length, and physiological cross-sectional area (PCSA) increased with strong positive allometry. As an indicator of force production capacity, the PCSA increased 30-fold with the changes in body mass; it grew rapidly during the nesting period and post-fledging period into sexual maturity...
May 5, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29727228/osteosarcopenia
#12
James Paintin, Cyrus Cooper, Elaine Dennison
Osteosarcopenia is a newly described syndrome that describes the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. Osteoporosis, a condition of low bone mass and micro-architectural deterioration of bone, and sarcopenia, the loss of muscle mass, strength and function, often co-exist in a frail subset of the elderly population, leading to significantly worsened outcomes than seen in either condition alone. These include a greater risk of falls, fractures and institutionalization, and significant socioeconomic costs...
May 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29722617/cheap-labor-myosin-fiber-type-expression-and-enzyme-activity-in-the-forelimb-musculature-of-sloths-pilosa-xenarthra
#13
Kyle B Spainhower, Rebecca N Cliffe, Allan K Metz, Ernest M Barkett, Paije M Kiraly, Dylan R Thomas, Sarah J Kennedy, Judy Avey-Arroyo, Michael T Butcher
Sloths are canopy-dwelling inhabitants of American neotropical rainforests that exhibit suspensory behaviors. These abilities require both strength and muscular endurance to hang for extended periods of time; however, the skeletal muscle mass of sloths is reduced, thus requiring modifications to muscle architecture and leverage for large joint torque. We hypothesize that intrinsic muscle properties also are modified for fatigue resistance and predict a heterogeneous expression of slow/fast myosin heavy chain (MHC) fibers that utilize oxidative metabolic pathways for economic force production...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29718926/bioengineered-intestinal-muscularis-complexes-with-long-term-spontaneous-and-periodic-contractions
#14
Qianqian Wang, Ke Wang, R Sergio Solorzano-Vargas, Po-Yu Lin, Christopher M Walthers, Anne-Laure Thomas, Martín G Martín, James C Y Dunn
Although critical for studies of gut motility and intestinal regeneration, the in vitro culture of intestinal muscularis with peristaltic function remains a significant challenge. Periodic contractions of intestinal muscularis result from the coordinated activity of smooth muscle cells (SMC), the enteric nervous system (ENS), and interstitial cells of Cajal (ICC). Reproducing this activity requires the preservation of all these cells in one system. Here we report the first serum-free culture methodology that consistently maintains spontaneous and periodic contractions of murine and human intestinal muscularis cells for months...
2018: PloS One
https://www.readbyqxmd.com/read/29716548/a-genome-wide-assessment-of-conserved-snp-alleles-reveals-a-panel-of-regulatory-snps-relevant-to-the-peripheral-nerve
#15
William D Law, Elizabeth A Fogarty, Aimée Vester, Anthony Antonellis
BACKGROUND: Identifying functional non-coding variation is critical for defining the genetic contributions to human disease. While single-nucleotide polymorphisms (SNPs) within cis-acting transcriptional regulatory elements have been implicated in disease pathogenesis, not all cell types have been assessed and functional validations have been limited. In particular, the cells of the peripheral nervous system have been excluded from genome-wide efforts to link non-coding SNPs to altered gene function...
May 2, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29708284/supersonic-shear-imaging-elastography-in-skeletal-muscles-relationship-between-in-vivo-and-synthetic-fiber-angles-and-shear-modulus
#16
Kelly Lima, Remi Rouffaud, Wagner Pereira, Liliam F Oliveira
OBJECTIVES: To verify a relationship between the pennation angle of synthetic fibers and muscle fibers with the shear modulus (μ) generated by Supersonic shear imaging (SSI) elastography and to compare the anisotropy of synthetic and in vivo pennate muscle fibers in the x2 -x3 plane (probe perpendicular to water surface or skin). METHODS: First, the probe of Aixplorer ultrasound scanner (v.9, Supersonic Imagine, Aix-en-Provence, France) was placed in 2 positions (parallel [aligned] and transverse to the fibers) to test the anisotropy in the x2 -x3 plane...
April 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29707959/acute-changes-in-muscle-thickness-and-pennation-angle-in-response-to-work-matched-concentric-and-eccentric-isokinetic-exercise
#17
Amilton Vieira, Anthony J Blazevich, Nuno Frade de Sousa, Rodrigo Celes, Savio Alex, James J Tufano, Martim Bottaro
Acute changes in muscle architecture influenced by muscle swelling might be associated with chronic adaptations to resistance exercise, including skeletal muscle growth. Concentric (CON) and eccentric (ECC) muscle actions both play a role in hypertrophic processes, but the influence of each on acute indices of muscle swelling [i.e. muscle thickness (MT) and pennation angle PA)] remain relatively unknown. Therefore, this study compared the acute changes in MT and PA in response to work-matched CON versus ECC isokinetic exercise...
April 30, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29700758/assessing-sarcopenia-with-vastus-lateralis-muscle-ultrasound-an-operative-protocol
#18
Andrea Ticinesi, Marco V Narici, Fulvio Lauretani, Antonio Nouvenne, Elena Colizzi, Marco Mantovani, Andrea Corsonello, Francesco Landi, Tiziana Meschi, Marcello Maggio
BACKGROUND: Muscle ultrasound (MUS) has so far not been implemented for sarcopenia assessment in clinical geriatric practice due to allegedly low reproducibility of results in the absence of standardization of procedures. However, rigorous and standardized application of this technique yields highly reproducible results. Its application, especially if integrated with clinical evaluation and comprehensive geriatric assessment, proofs very useful for rapidly obtaining information on muscle mass and architecture...
April 26, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29683410/the-effect-of-dry-needling-on-spasticity-gait-and-muscle-architecture-in-patients-with-chronic-stroke-a-case-series-study
#19
Sarafraz Hadi, Otadi Khadijeh, Mohammadreza Hadian, Ayoobi Yazdi Niloofar, Gholamreza Olyaei, Bagheri Hossein, Sandra Calvo, Pablo Herrero
Objectives The objective of this study was to assess the short-term effects of dry needling on spasticity, gait, and muscle architecture of patients with chronic stroke. Methods A case series study was designed; and six chronic stroke patients with ankle spasticity and gait impairment received a single session of dry needling for gastrocnemius medialis, lateralis, and soleus muscles. The main outcome measures were the Modified Modified Ashworth Scale (MMAS), and Timed Up and Go test (TUG). In addition, ultrasonography measurements (e...
April 23, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29682414/three-dimensional-architecture-of-the-whole-human-soleus-muscle-in-vivo
#20
Bart Bolsterlee, Taija Finni, Arkiev D'Souza, Junya Eguchi, Elizabeth C Clarke, Robert D Herbert
Background: Most data on the architecture of the human soleus muscle have been obtained from cadaveric dissection or two-dimensional ultrasound imaging. We present the first comprehensive, quantitative study on the three-dimensional anatomy of the human soleus muscle in vivo using diffusion tensor imaging (DTI) techniques. Methods: We report three-dimensional fascicle lengths, pennation angles, fascicle curvatures, physiological cross-sectional areas and volumes in four compartments of the soleus at ankle joint angles of 69 ± 12° (plantarflexion, short muscle length; average ± SD across subjects) and 108 ± 7° (dorsiflexion, long muscle length) of six healthy young adults...
2018: PeerJ
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