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muscle architecture

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https://www.readbyqxmd.com/read/27932703/an-in%C3%A2-vivo-pilot-study-of-a-microporous-thin-film-nitinol-covered-stent-to-assess-the-effect-of-porosity-and-pore-geometry-on-device-interaction-with-the-vessel-wall
#1
Youngjae Chun, Colin P Kealey, Daniel S Levi, David A Rigberg, Yanfei Chen, Bryan W Tillman, K P Mohanchandra, Mahdis Shayan, Gregory P Carman
Sputter-deposited thin film nitinol constructs with various micropatterns were fabricated to evaluate their effect on the vessel wall in vivo when used as a covering for commercially available stents. Thin film nitinol constructs were used to cover stents and deployed in non-diseased swine arteries. Swine were sacrificed after approximately four weeks and the thin film nitinol-covered stents were removed for histopathologic evaluation. Histopathology revealed differences in neointimal thickness that correlated with the thin film nitinol micropattern...
December 8, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27921211/helix-o-modulates-voltage-dependency-of-clc-1
#2
Ju Yong Seong, Kotdaji Ha, Chansik Hong, Jongyun Myeong, Hyun-Ho Lim, Dongki Yang, Insuk So
The chloride channel (CLC) family of proteins consists of channels and transporters that share similarities in architecture and play essential roles in physiological functions. Among the CLC family, CLC-1 channels have the representative homodimeric double-barreled structure carrying two gating processes. One is protopore gating that acts on each pore independently by glutamate residue (Eext). The other is common gating that closes both pores simultaneously in association with large conformational changes across each subunit...
December 5, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27919416/a-3d-model-of-the-achilles-tendon-to-determine-the-mechanisms-underlying-nonuniform-tendon-displacements
#3
Geoffrey G Handsfield, Joshua M Inouye, Laura C Slane, Darryl G Thelen, G Wilson Miller, Silvia S Blemker
The Achilles is the thickest tendon in the body and is the primary elastic energy-storing component during running. The form and function of the human Achilles is complex: twisted structure, intratendinous interactions, and differential motor control from the triceps surae muscles make Achilles behavior difficult to intuit. Recent in vivo imaging of the Achilles has revealed nonuniform displacement patterns that are not fully understood and may result from complex architecture and musculotendon interactions...
November 28, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27907186/inter-tissue-gene-co-expression-networks-between-metabolically-healthy-and-unhealthy-obese-individuals
#4
Lisette J A Kogelman, Jingyuan Fu, Lude Franke, Jan Willem Greve, Marten Hofker, Sander S Rensen, Haja N Kadarmideen
BACKGROUND: Obesity is associated with severe co-morbidities such as type 2 diabetes and nonalcoholic steatohepatitis. However, studies have shown that 10-25 percent of the severely obese individuals are metabolically healthy. To date, the identification of genetic factors underlying the metabolically healthy obese (MHO) state is limited. Systems genetics approaches have led to the identification of genes and pathways in complex diseases. Here, we have used such approaches across tissues to detect genes and pathways involved in obesity-induced disease development...
2016: PloS One
https://www.readbyqxmd.com/read/27906101/characterization-of-a-dmd-egfp-reporter-mouse-as-a-tool-to-investigate-dystrophin-expression
#5
Mina V Petkova, Susanne Morales-Gonzales, Karima Relizani, Esther Gill, Franziska Seifert, Josefine Radke, Werner Stenzel, Luis Garcia, Helge Amthor, Markus Schuelke
BACKGROUND: Dystrophin is a rod-shaped cytoplasmic protein that provides sarcolemmal stability as a structural link between the cytoskeleton and the extracellular matrix via the dystrophin-associated protein complex (DAPC). Mutations in the dystrophin-encoding DMD gene cause X-linked dystrophinopathies with variable phenotypes, the most severe being Duchenne muscular dystrophy (DMD) characterized by progressive muscle wasting and fibrosis. However, dystrophin deficiency does not only impair the function of skeletal and heart muscle but may also affect other organ systems such as the brain, eye, and gastrointestinal tract...
July 5, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27906061/laminin-and-matrix-metalloproteinase-11-regulate-fibronectin-levels-in-the-zebrafish-myotendinous-junction
#6
Molly H Jenkins, Sarah S Alrowaished, Michelle F Goody, Bryan D Crawford, Clarissa A Henry
BACKGROUND: Remodeling of the extracellular matrix (ECM) regulates cell adhesion as well as signaling between cells and their microenvironment. Despite the importance of tightly regulated ECM remodeling for normal muscle development and function, mechanisms underlying ECM remodeling in vivo remain elusive. One excellent paradigm in which to study ECM remodeling in vivo is morphogenesis of the myotendinous junction (MTJ) during zebrafish skeletal muscle development. During MTJ development, there are dramatic shifts in the primary components comprising the MTJ matrix...
May 2, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27900777/muscular-pattern-in-three-species-of-macrostomum-platyhelminthes-macrostomorpha
#7
Mariana L Adami, Francisco Brusa, Jorge R Ronderos, Cristina Damborenea
Previous studies demonstrated complex architecture of the muscular system of Macrostomum species, especially in the rostrum area and the pharynx. However, little is known about the differences in muscular pattern between species of the genus. This study examines and compares the muscular systems of specimens belonging to three freshwater Macrostomum species (M. quiritium, M. tuba and M. velastylum), labeled with phalloidin-rhodamine and studied by confocal microscopy. Our results agree with the previous descriptions, confirming that the muscular patterns for the body wall, rostrum area, pharynx and caudal region differ among species...
November 29, 2016: Journal of Morphology
https://www.readbyqxmd.com/read/27899160/physiopathology-of-vesico-ureteral-reflux
#8
REVIEW
Salvatore Arena, Roberta Iacona, Pietro Impellizzeri, Tiziana Russo, Lucia Marseglia, Eloisa Gitto, Carmelo Romeo
Vescico-Ureteral Reflux (VUR) is a common condition in childhood, caused by a congenital anomaly at the Vescico-Ureteral Junction (VUJ) level. It seems that the main cause could be an abnormal embryological development occurred during the early stage of fetal life.Refluxing ureteral endings show structural and functional anomalies: previous studies have shown a significant decrease in alfa actin, miosin and desmin contents as well as an high rate of atrophy and muscular degeneration with disorganized muscular fibres...
November 29, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27896299/basement-membrane-ultrastructure-and-component-localization-data-from-uterine-tissues-during-early-mouse-pregnancy
#9
Celestial R Jones-Paris, Sayan Paria, Taloa Berg, Juan Saus, Gautam Bhave, Bibhash C Paria, Billy G Hudson
Basement membranes (BMs) are specialized extracellular scaffolds that provide architecture and modulate cell behaviors in tissues, such as fat, muscle, endothelium, endometrium, and decidua. Properties of BMs are maintained in homeostasis for most adult tissues. However, BM ultrastructure, composition, and localization are rapidly altered in select uterine tissues that are reprogrammed during pregnancy to enable early maternal-embryo interactions. Here, our data exhibit both static and dynamic BMs that were tracked in mouse uterine tissues during pre-, peri-, and postimplantation periods of pregnancy...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27896273/relationships-between-muscle-architecture-of-rectus-femoris-and-functional-parameters-of-knee-motion-in-adults-with-down-syndrome
#10
Maria Stella Valle, Antonino Casabona, Marco Micale, Matteo Cioni
This study was designed to measure in vivo muscle architecture of the rectus femoris in adults with Down syndrome, testing possible relationships with functional parameters of the knee motion. Ten adults with Down syndrome and ten typically developed participated in the study. Pennation angle and thickness of the rectus femoris and subcutaneous layer of the thigh were measured via ultrasound imaging. Knee kinematics and electromyographic activity of the rectus femoris were recorded during free leg dropping...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27894277/human-limb-skeletal-muscle-wasting-and-architectural-remodeling-during-five-to-ten-days-intubation-and-ventilation-in-critical-care-an-observational-study-using-ultrasound
#11
Peter Turton, Richard Hay, Jonathon Taylor, Jamie McPhee, Ingeborg Welters
BACKGROUND: Critically ill patients frequently suffer muscle weakness whilst in critical care. Ultrasound can reliably track loss of muscle size, but also quantifies the arrangement of the muscle fascicles, known as the muscle architecture. We sought to measure both pennation angle and fascicle length, as well as tracking changes in muscle thickness in a population of critically ill patients. METHODS: On days 1, 5 and 10 after admission to critical care, muscle thickness was measured in ventilated critically ill patients using bedside ultrasound...
November 29, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27890729/maturation-of-human-embryonic-stem-cell-derived-cardiomyocytes-hesc-cms-in-3d-collagen-matrix-effects-of-niche-cell-supplementation-and-mechanical-stimulation
#12
W Zhang, C W Kong, M H Tong, W H Chooi, N Huang, R A Li, B P Chan
: Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) are regarded as a promising source for regenerative medicine, drug testing and disease modeling. Nevertheless, cardiomyocytes are immature in terms of their contractile structure, metabolism and electrophysiological properties. Here, we fabricate cardiac muscle strips by encapsulating hESC-CMs in collagen-based biomaterials. Supplementation of niche cells at 3% to the number of hESC-CMs enhance the maturation of the hESC-CMs in 3D tissue matrix...
November 24, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27888744/bilateral-changes-in-muscle-architecture-of-physically-active-people-with-chronic-stroke-a-quantitative-muscle-ultrasound-study
#13
Frank Berenpas, Anne-Marieke Martens, Vivian Weerdesteyn, Alexander C Geurts, Nens van Alfen
OBJECTIVE: Changes in muscle architecture after stroke are usually assessed by investigating inter-limb differences. As a result bilateral changes of muscle architecture might be missed. Our aim was to investigate whether bilateral architectural changes in skeletal muscle can be detected in chronic, physically active stroke patients using quantitative muscle ultrasound (QMUS). METHODS: Twenty-eight patients (mean time since stroke 5.2years, median Brunnström stage 4) were recruited...
November 11, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27885900/recreating-composition-structure-functionalities-of-tissues-at-nanoscale-for-regenerative-medicine
#14
Emine Alarçin, Xiaofei Guan, Sara Saheb Kashaf, Khairat Elbaradie, Huazhe Yang, Hae Lin Jang, Ali Khademhosseini
Nanotechnology offers significant potential in regenerative medicine, specifically with the ability to mimic tissue architecture at the nanoscale. In this perspective, we highlight key achievements in the nanotechnology field for successfully mimicking the composition and structure of different tissues, and the development of bio-inspired nanotechnologies and functional nanomaterials to improve tissue regeneration. Numerous nanomaterials fabricated by electrospinning, nanolithography and self-assembly have been successfully applied to regenerate bone, cartilage, muscle, blood vessel, heart and bladder tissue...
December 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27878409/analysis-of-the-functional-muscle-bone-unit-of-the-forearm-in-patients-with-phenylketonuria-by-peripheral-quantitative-computed-tomography
#15
Daniela Choukair, Carolin Kneppo, Reinhard Feneberg, Eckhard Schönau, Martin Lindner, Stefan Kölker, Georg F Hoffmann, Burkhard Tönshoff
Bone disease in patients with phenylketonuria (PKU) is incompletely characterized. We therefore analyzed, in a cross-sectional study radius macroscopic bone architecture and forearm muscle size by peripheral quantitative computed tomography (pQCT) and muscle strength by hand dynamometry in a large cohort (n = 56) of adolescent and adult patients with PKU aged 26.0 ± 8.9 (range, 11.8-41.5) years. Data were compared with a reference population (n = 700) from the DONALD study using identical methodology...
November 22, 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27872012/biomimetic-collagen-elastin-meshes-for-ventral-hernia-repair-in-a-rat-model
#16
Silvia Minardi, Francesca Taraballi, Xin Wang, Fernando J Cabrera, Jeffrey L Van Eps, Andrew B Robbins, Monica Sandri, Michael R Moreno, Bradley K Weiner, Ennio Tasciotti
: Ventral hernia repair remains a major clinical need. Herein, we formulated a type I collagen/elastin crosslinked blend (CollE) for the fabrication of biomimetic meshes for ventral hernia repair. To evaluate the effect of architecture on the performance of the implants, CollE was formulated both as flat sheets (CollE Sheets) and porous scaffolds (CollE Scaffolds). The morphology, hydrophylicity and in vitro degradation were assessed by SEM, water contact angle and differential scanning calorimetry, respectively...
November 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27870350/the-periosteum-of-the-zygomatic-arch-vascularization-and-growth
#17
Susan W Herring, Pannee Ochareon
In addition to conveying the forces of attaching muscles and ligaments to the zygomatic and temporal bones, the arch periosteum is responsible for lateral apposition and medial resorption during the growth period. In this contribution, we describe the vasculature of the zygomatic arch in young pigs (Sus scrofa dom.) in order to understand the relationship of osseous and periosteal vessels to each other, to surrounding tissues, and to patterns of modeling. Subjects 2-6 weeks of age were perfused with vascular fill; some also received the vital bone label calcein...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27870345/betwixt-and-between-intracranial-perspective-on-zygomatic-arch-plasticity-and-function-in-mammals
#18
Erin M Franks, Nathan E Holton, Jeremiah E Scott, Kevin R McAbee, Jason T Rink, Kazune C Pax, Adam C Pasquinelly, Joseph P Scollan, Meghan M Eastman, Matthew J Ravosa
The zygomatic arch is morphologically complex, providing a key interface between the viscerocranium and neurocranium. It also serves as an attachment site for masticatory muscles, thereby linking it to the feeding apparatus. Though morphological variation related to differential loading is well known for many craniomandibular elements, the adaptive osteogenic response of the zygomatic arch remains to be investigated. Here, experimental data are presented that address the naturalistic influence of masticatory loading on the postweaning development of the zygoma and other cranial elements...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27870339/zygomatic-arch-cortical-area-and-diet-in-haplorhines
#19
Hallie Edmonds
The influence that various types of ingested foods have on the form (size and shape) of specific features of the masticatory system is an area in which many questions remain unanswered. The bony zygomatic arch, the focus of this study, is directly linked to the masticatory system because it serves as the anchor for the masseter muscle, a primary muscle of chewing and source of masticatory force. However, the influence of diet and the forces associated with different diet types on the arch's internal bone architecture is not well understood...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27865007/anisotropic-materials-for-skeletal-muscle-tissue-engineering
#20
Soumen Jana, Sheeny K Lan Levengood, Miqin Zhang
Repair of damaged skeletal-muscle tissue is limited by the regenerative capacity of the native tissue. Current clinical approaches are not optimal for the treatment of large volumetric skeletal-muscle loss. As an alternative, tissue engineering represents a promising approach for the functional restoration of damaged muscle tissue. A typical tissue-engineering process involves the design and fabrication of a scaffold that closely mimics the native skeletal-muscle extracellular matrix (ECM), allowing organization of cells into a physiologically relevant 3D architecture...
November 16, 2016: Advanced Materials
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