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https://www.readbyqxmd.com/read/27900450/il-9-and-th9-in-parasite-immunity
#1
REVIEW
P Licona-Limón, A Arias-Rojas, E Olguín-Martínez
Interleukin-9 is a cytokine classically related to type 2 immune responses whose cellular identity has been recently reevaluated to identify a new specialized T helper subset called Th9 and an innate source referred as innate lymphoid cell type 2. Over the past years, IL-9 has been associated with allergic responses, tumor immunology, and autoimmunity; however, in this review, we will specifically focus on the role of IL-9 and Th9 cells in the context of parasitic infections. We will summarize and discuss all the evidence relating IL-9 expression and function in parasitic infections with a particular emphasis in helminth infections, an important health issue in developing countries; we will also provide a general description and classification of parasites, the immune response and cellular compartments activated in this context, and its implications and future directions towards a complete understanding of this interesting new T helper subset and its potential therapeutic use...
November 29, 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/27855043/-association-of-ovarian-tumors-with-ca-125
#2
Judith Elena Martínez-Acosta, Víctor Alberto Olguín-Cruces
BACKGROUND: The tumor marker CA-125 is the most widely used serum marker for ovarian cancer screening. The aim of this paper was to establish the association between histopathologic result of ovarian tumors with serologic CA-125 and utility for the diagnosis of ovarian tumors at a Ginecoobstetric hospital. METHODS: An observational, retrospective, descriptive and longitudinal study, from September 1st 2010 to February 28 2013. All patients with histopathologic report ovarian tumor and CA-125 was selected to analyze the association of ovarian tumors with their histological type, biological behavior, range positivity of CA-125 and its relationship to the pre and postmenopausal state...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27819781/-brain-death-attitude-and-knowledge-of-medical-personnel-in-a-third-level-hospital
#3
Martín Santibáñez-Velázquez, Erika Olguín-Sánchez, Adrián Ángeles-Vélez, Bertha Angélica García-García
BACKGROUND: Brain death is defined as the irreversible loss of all functions of the brain, including the brainstem. The objective is to know the attitude and knowledge toward brain death of the medical personnel involved in the process of the organ/tissue transplantation and donation in a third level hospital of Mexico City. METHODS: 67 attending physicians were interviewed with the methodology of pen, paper and a printed questionnaire. They were distributed in two groups: group A, consisting of non-surgical physicians, and group B, which was formed by surgical physicians...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27809263/in-vitro-antimicrobial-activity-of-embothrium-coccineum-used-as-traditional-medicine-in-patagonia-against-multiresistant-bacteria
#4
Nicole Canales, Iván Montenegro, Mario Párraga, Yusser Olguín, Patricio Godoy, Enrique Werner, Alejandro Madrid
Embothrium coccineum J.R. Forst. & G. Forst is an evergreen tree that has been used as a folk remedy for the treatment of neuralgia, tooth pains, wound healing, and glandular conditions, as well as an antiseptic agent against bacterial infection. The antibacterial activities of sequential extracts (hexane, dichloromethane, ethyl acetate, and ethanol) from the leaves of E. coccineum were evaluated by means of the micro-dilution assay against six (Escherichia coli; Klebsiella pneumoniae; Proteus mirabilis; Pseudomonas aeruginosa; Staphylococcus aureus and Streptococcus pyogenes) multiresistant bacteria strains...
October 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27754468/molecular-epidemiology-and-spatio-temporal-dynamics-of-the-h3n8-equine-influenza-virus-in-south-america
#5
Cecilia Olguin Perglione, Marcelo D Golemba, Carolina Torres, Maria Barrandeguy
Equine influenza virus (EIV) is considered the most important respiratory pathogen of horses as outbreaks of the disease lead to substantial economic losses. The H3N8 EIV has caused respiratory disease in horses across the world, including South American countries. Nucleotide and deduced amino acid sequences for the complete haemagglutinin gene of the H3N8 EIV detected in South America since 1963 were analyzed. Phylogenetic and Bayesian coalescent analyses were carried out to study the origin, the time of the most recent common ancestors (tMRCA), the demographic and the phylogeographic patterns of the H3N8 EIV...
October 16, 2016: Pathogens
https://www.readbyqxmd.com/read/27741429/altered-csf-cytokine-network-in-amyotrophic-lateral-sclerosis-patients-a-pathway-based-statistical-analysis
#6
Hector R Martínez, César E Escamilla-Ocañas, Juan Miguel Tenorio-Pedraza, David Gómez-Almaguer, Jose Carlos Jaime-Perez, Leticia A Olguín-Ramírez, Sergio Salazar-Marioni, María Teresa González-Garza
INTRODUCTION: Increased cytokine expression is a prominent finding in amyotrophic lateral sclerosis (ALS). Due to their interdependence and pleiotropism, interpretation of CSF concentrations of a single cytokine is challenging. We describe a cytokine analysis in ALS patients using a pathway-based statistical method to identify changes in the whole cytokine network. METHODS: We analyzed 19 cytokines in CSF of ALS patients and controls. An equality of concentration matrices was conducted that allowed us to evaluate disturbances in the relationship of cytokines between controls and ALS patients with less and more than 12months of disease length...
October 11, 2016: Cytokine
https://www.readbyqxmd.com/read/27718141/promoting-interdomain-analogical-transfer-when-creating-a-problem-helps-to-solve-a-problem
#7
Ricardo A Minervino, Valeria Olguín, Máximo Trench
Research on analogical thinking has devised several ways of promoting an abstract encoding of base analogs, thus rendering them more retrievable during later encounters with similar situations lacking surface similarities. Recent studies have begun to explore ways of facilitating transfer at retrieval time, which could facilitate the retrieval of distant analogs learned within contexts that were not specially directed to emphasize their abstract structure. Such studies demonstrate that comparing a target problem to an analogous problem helps students retrieve base analogs that lack surface similarities...
October 7, 2016: Memory & Cognition
https://www.readbyqxmd.com/read/27649609/comparison-between-silver-and-copper-modified-zeolite-rich-tuffs-as-microbicide-agents-for-escherichia-coli-and-candida-albicans
#8
L G Rossainz-Castro, I De-La-Rosa-Gómez, M T Olguín, D Alcántara-Díaz
Zeolite-rich tuff from the State of Chihuahua was modified with silver or copper ions (ZChAg and ZChCu) to evaluate its microbicidal effect against Escherichia coli (E. coli) and Candida albicans (C. albicans) suspended in an aqueous solution in order to compare the microbial disinfection kinetics between bacteria and yeast. The zeolite-rich tuff was treated with AgNO3 or CuCl2 solutions. The materials obtained were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD) and the textural properties were also determined by BET-analyses...
December 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27616990/locus-ceruleus-norepinephrine-release-a-central-regulator-of-cns-spatio-temporal-activation
#9
Marco Atzori, Roberto Cuevas-Olguin, Eric Esquivel-Rendon, Francisco Garcia-Oscos, Roberto C Salgado-Delgado, Nadia Saderi, Marcela Miranda-Morales, Mario Treviño, Juan C Pineda, Humberto Salgado
Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from where it is released by axonal varicosities throughout the brain via volume transmission. A wealth of data from clinics and from animal models indicates that this catecholamine coordinates the activity of the central nervous system (CNS) and of the whole organism by modulating cell function in a vast number of brain areas in a coordinated manner. The ubiquity of NE receptors, the daunting number of cerebral areas regulated by the catecholamine, as well as the variety of cellular effects and of their timescales have contributed so far to defeat the attempts to integrate central adrenergic function into a unitary and coherent framework...
2016: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/27609401/the-synergic-in-vitro-tocolytic-effect-of-nifedipine-plus-ritodrine-on-human-myometrial-contractility
#10
Jorge Andrés Carvajal, María José Zambrano, Nur Mónica Theodor, Luis Emilio Moreno, Thiare Rosario Olguín, Paula Sofía Vanhauwaert, Nevenka Belén Rojas, Ana María Delpiano
Many pharmacological agents have been investigated to manage preterm labor; we postulate that a combination of tocolytic drugs may achieve a better effect in the prevention of uterine contractions without dose-dependent adverse effects. The aim of this study was to evaluate the inhibitory effect of dual combinations of tocolytics in vitro. Human myometrium was obtained during elective cesarean sections (term without labor; n = 40). Myometrial strips were placed in organ baths for the measurement of isometric tension...
September 7, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27593555/chitosan-poly-octanoic-acid-2-thiophen-3-yl-ethyl-ester-blends-as-a-scaffold-to-maintain-myoblasts-regeneration-potential-in-vitro
#11
Cristina Padilla, Andrea Ramos, Natalia González, Mauricio Isaacs, Flavia Zacconi, Hugo C Olguín, Loreto M Valenzuela
Satellite cells are a small cell population that function as muscle-specific adult stem cells. When muscle damage occurs, these cells are able to activate, proliferate, and ultimately fuse with each other in order to form new myofibers or fuse with existing ones. For tissue engineering applications, obtaining a sufficient number of myoblasts prior transplantation that maintains their regenerative capacity is critical. This can be obtained by in vitro expansion of autologous satellite cells. However, once plated, the self-renewal and regenerative capacity of myoblasts is rapidly lost, obtaining low yields per biopsy...
January 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27585845/establishment-of-the-muscle-tendon-junction-during-thorax-morphogenesis-in-drosophila-requires-the-rho-kinase
#12
Franco Vega-Macaya, Catalina Manieu, Mauricio Valdivia, Marek Mlodzik, Patricio Olguín
The assembly of the musculoskeletal system in Drosophila relies on the integration of chemical and mechanical signaling between the developing muscles with ectodermal cells specialized as "tendon cells". Mechanical tension generated at the junction of flight muscles and tendon cells of the notum epithelium is required for muscle morphogenesis and is balanced by the epithelium in order to not deform. We report that Drosophila Rho kinase (Drok) is necessary in tendon cells to assemble stable myotendinous junctions (MTJ), which are required for muscle morphogenesis and survival...
August 31, 2016: Genetics
https://www.readbyqxmd.com/read/27573697/presynaptic-dlg-regulates-synaptic-function-through-the-localization-of-voltage-activated-ca-2-channels
#13
César Astorga, Ramón A Jorquera, Mauricio Ramírez, Andrés Kohler, Estefanía López, Ricardo Delgado, Alex Córdova, Patricio Olguín, Jimena Sierralta
The DLG-MAGUK subfamily of proteins plays a role on the recycling and clustering of glutamate receptors (GLUR) at the postsynaptic density. discs-large1 (dlg) is the only DLG-MAGUK gene in Drosophila and originates two main products, DLGA and DLGS97 which differ by the presence of an L27 domain. Combining electrophysiology, immunostaining and genetic manipulation at the pre and postsynaptic compartments we study the DLG contribution to the basal synaptic-function at the Drosophila larval neuromuscular junction...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27553016/medical-comorbidity-of-binge-eating-disorder
#14
Pablo Olguin, Manuel Fuentes, Guillermo Gabler, Anna I Guerdjikova, Paul E Keck, Susan L McElroy
PURPOSE: To gain further understanding of the general medical comorbidity of binge eating disorder (BED) beyond its association with obesity. METHOD: We reviewed studies of general medical comorbidity in people with BED or clinically significant binge eating behavior beyond obesity. We also reviewed studies of BED in specific medical conditions. RESULTS: Three broad study categories of medical comorbidity in BED were found: cross-sectional studies of medical conditions in BED; prospective studies of medical conditions in BED; and studies of BED in specific medical conditions...
August 23, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/27542582/-upper-limb-functional-assessment-scale-for-children-with-duchenne-muscular-dystrophy-and-spinal-muscular-atrophy
#15
Raúl G Escobar, Nayadet Lucero, Carmen Solares, Victoria Espinoza, Odalie Moscoso, Polín Olguín, Karin T Muñoz, Ricardo Rosas
INTRODUCTION: Duchenne muscular dystrophy (DMD) and Spinal muscular atrophy (SMA) causes significant disability and progressive functional impairment. Readily available instruments that assess functionality, especially in advanced stages of the disease, are required to monitor the progress of the disease and the impact of therapeutic interventions. OBJECTIVE: To describe the development of a scale to evaluate upper limb function (UL) in patients with DMD and SMA, and describe its validation process, which includes self-training for evaluators...
August 16, 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27485011/tolerogenic-dendritic-cells-for-reprogramming-of-lymphocyte-responses-in-autoimmune-diseases
#16
Paulina García-González, Gabriela Ubilla-Olguín, Diego Catalán, Katina Schinnerling, Juan Carlos Aguillón
Dendritic cells (DCs) control immune responses by driving potent inflammatory actions against external and internal threats while generating tolerance to self and harmless components. This duality and their potential to reprogram immune responses in an antigen-specific fashion have made them an interesting target for immunotherapeutic strategies to control autoimmune diseases. Several protocols have been described for in vitro generation of tolerogenic DCs (tolDCs) capable of modulating adaptive immune responses and restoring tolerance through different mechanisms that involve anergy, generation of regulatory lymphocyte populations, or deletion of potentially harmful inflammatory T cell subsets...
July 30, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27297185/isolation-of-bdellovibrio-sp-from-soil-samples-in-mexico-and-their-potential-applications-in-control-of-pathogens
#17
Omotayo Opemipo Oyedara, Erick de Jesus De Luna-Santillana, Omar Olguin-Rodriguez, Xianwu Guo, Marco Antonio Mendoza-Villa, Jorge Luis Menchaca-Arredondo, Temidayo Oluyomi Elufisan, Javier Alfonso Garza-Hernandez, Israel Garcia Leon, Mario Alberto Rodriguez-Perez
In this study, two strains of Bdellovibrio were isolated from soil samples using the culture-dependent technique and two members of the family Enterobacteriaceae (Klebsiella sp. and Salmonella sp.) as prey. The Bdellovibrio strains were bacteriolytic, plaque-forming, and highly motile gram-negative bacteria. We identified and confirmed the Bdellovibrio strains using microscopy, PCR amplification, and sequencing of the 16S rRNA gene. They were observed to be different strains based on hit locus and prey range analyses...
June 13, 2016: MicrobiologyOpen
https://www.readbyqxmd.com/read/27241350/methylmercury-induced-developmental-toxicity-is-associated-with-oxidative-stress-and-cofilin-phosphorylation-cellular-and-human-studies
#18
Beatriz Caballero, Nair Olguin, Francisco Campos, Marcelo Farina, Ferran Ballester, Maria-Jose Lopez-Espinosa, Sabrina Llop, Eduard Rodríguez-Farré, Cristina Suñol
Environmental exposure to methylmercury (MeHg) during development is of concern because it is easily incorporated in children's body both pre- and post-natal, it acts at several levels of neural pathways (mitochondria, cytoskeleton, neurotransmission) and it causes behavioral impairment in child. We evaluated the effects of prolonged exposure to 10-600nM MeHg on primary cultures of mouse cortical (CCN) and of cerebellar granule cells (CGC) during their differentiation period. In addition, it was studied if prenatal MeHg exposure correlated with altered antioxidant defenses and cofilin phosphorylation in human placentas (n=12) from the INMA cohort (Spain)...
May 27, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27179576/assessment-of-the-effects-of-oseltamivir-and-indomethacin-on-dopamine-5-hiaa-and-some-oxidative-stress-markers-in-stomach-and-brain-of-salmonella-typhimurium-infected-rats
#19
David Calderón Guzmán, Maribel Ortiz Herrera, Norma Osnaya Brizuela, Gerardo Barragán Mejía, Francisca Trujillo Jiménez, Ernestina Hernández García, Hugo Juárez Olguín
OBJECTIVES: The purpose of this study was to measure the effect of oseltamivir and indomethacin on dopamine and 5-HIAA levels and some oxidative biomarkers in brain and stomach of young rats in conditions of infection. METHODS: Female Sprague Dawley rats in absence or presence of a live culture of Salmonella typhimurium (S.Typh), were treated as follows: PBS, group 1 (control); oseltamivir (100 mg/kg), group 2; indomethacin (67 µg/kg) group 3; oseltamivir (100 mg/kg) + indomethacin (67 µg/kg), group 4...
2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27157521/analysis-of-activity-and-motor-coordination-in-rats-undergoing-stereotactic-surgery-and-implantation-of-a-cannula-into-the-dorsal-hippocampus
#20
F Hernández-López, J F Rodríguez-Landa, A Puga-Olguín, L J Germán-Ponciano, E Rivadeneyra-Domínguez, B Bernal-Morales
INTRODUCTION: Stereotactic surgery is used to place electrodes or cannulas in the brain in order to study the function of several brain structures in preclinical research. The hippocampus has been extensively studied with this methodology due to its involvement in a wide range of neurological, cognitive, emotional, and affective disorders. However, the effects of stereotactic surgery on coordination and motor activity should be evaluated in order to determine whether this surgical procedure causes any neurological alterations that may bias the results of studies incorporating this technique...
May 5, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
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