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https://www.readbyqxmd.com/read/28539708/assessment-of-mexican-arnica-heterotheca-inuloides-cass-and-rosemary-rosmarinus-officinalis-extracts-on-dopamine-and-selected-biomarkers-of-oxidative-stress-in-stomach-and-brain-of-salmonella-typhimurium-infected-rats
#1
David Calderón Guzmàn, Maribel Ortiz Herrera, Norma Osnaya Brizuela, Gerardo Barragàn Mejía, Ernestina Hernàndez García, Hugo Juàrez Olguín, Armando Valenzuela Peraza, Norma Labra Ruíz, Daniel Santamaría Del Angel
BACKGROUND: The effects of some natural products on dopamine (DA) and 5-hydroxyindole acetic acid (5-HIAA) in brain of infected models are still unclear. OBJECTIVE: The purpose of this study was to measure the effect of Mexican arnica/rosemary (MAR) water extract and oseltamivir on both biogenic amines and some oxidative biomarkers in the brain and stomach of young rats under infection condition. METHODS: Female Wistar rats (weight 80 g) in the presence of MAR or absence (no-MAR) were treated as follows: group 1, buffer solution (controls); oseltamivir (100 mg/kg), group 2; culture of Salmonella typhimurium (S...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28535183/time-caloric-restriction-inhibits-the-neoplastic-transformation-of-cirrhotic-liver-in-rats-treated-with-diethylnitrosamine
#2
Christian Molina-Aguilar, María de Jesús Guerrero-Carrillo, Jesús Javier Espinosa-Aguirre, Sitlali Olguin-Reyes, Thania Castro-Belio, Olivia Vázquez-Martínez, Julieta Berenice Rivera-Zavala, Mauricio Díaz-Muñoz
Hepatocellular cancer is the most common type of primary liver cancer. Cirrhosis is the main risk factor that generates this malady. It has been proven that caloric restriction protocols and restricted feeding schedules are protective in experimental carcinogenic models. We tested the influence of a time-caloric restriction protocol (2 h of food access during the daytime for 18 weeks) in an experimental model of cirrhosis-hepatocarcinoma produced by weekly administration of diethylnitrosamine. Our results indicate that time-caloric restriction reduced hepatomegaly and prevented the increase in blood leukocytes promoted by diethylnitrosamine...
May 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28533272/chimeric-pd-1-28-receptor-upgrades-low-avidity-t-cells-and-restores-effector-function-of-tumor-infiltrating-lymphocytes-for-adoptive-cell-therapy
#3
Ramona Schlenker, Luis Felipe Olguín-Contreras, Matthias Leisegang, Julia Schnappinger, Anja Disovic, Svenja Rühland, Peter J Nelson, Heinrich Leonhardt, Hartmann Harz, Susanne Wilde, Dolores J Schendel, Wolfgang Uckert, Gerald Willimsky, Elfriede Noessner
Inherent intermediate-to-low affinity T cell receptors (TCR) that develop during the natural course of immune responses may not allow sufficient activation for tumor elimination, making the majority of T cells suboptimal for adoptive T cell therapy (ATT). TCR affinity enhancement has been implemented to provide stronger T cell activity but carries the risk of creating undesired cross-reactivity leading to potential serious adverse effects in clinical application. We demonstrate here that engineering of low-avidity T cells recognizing a naturally processed and presented tumor-associated antigen with a chimeric PD-1:28 receptor increases effector function to levels seen with high-avidity T cells of identical specificity...
May 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28521531/removal-of-co-by-carbonaceous-material-obtained-through-solution-combustion-of-tamarind-shell
#4
H López-González, J Serrano-Gómez, M T Olguín, J Hernández-López, S Bulbulian
New carbonaceous materials were obtained through solution combustion process of tamarind shell in the presence of urea and ammonium nitrate, and all of them were tested for Co removal. The effect of temperature (from 600°C to 1000°C) and water volume on surface texture of carbonaceous material and its adsorptive capacity was evaluated. Scanning electron microscope, FTIR, XRD and BET model were used to characterize the obtained carbonaceous material before applying for the removal of cobalt. The point of zero charge was also determined...
May 19, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28492284/inhibition-of-corticotropin-releasing-hormone-receptor-1-and-activation-of-receptor-2-protect-against-colonic-injury-and-promote-epithelium-repair
#5
Bo Li, Carol Lee, Tali Filler, Alison Hock, Richard You Wu, Qi Li, Shigang Chen, Yuhki Koike, Wan Ip, Lijun Chi, Elke Zani-Ruttenstock, Pekka Määttänen, Tanja Gonska, Paul Delgado-Olguin, Augusto Zani, Philip M Sherman, Agostino Pierro
Maternal separation (MS) in neonates can lead to intestinal injury. MS in neonatal mice disrupts mucosal morphology, induces colonic inflammation and increases trans-cellular permeability. Several studies indicate that intestinal epithelial stem cells are capable of initiating gut repair in a variety of injury models but have not been reported in MS. The pathophysiology of MS-induced gut injury and subsequent repair remains unclear, but communication between the brain and gut contribute to MS-induced colonic injury...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28482939/daytime-restricted-feeding-modifies-the-daily-regulation-of-fatty-acid-%C3%AE-oxidation-and-the-lipoprotein-profile-in-rats
#6
J B Rivera-Zavala, C Molina-Aguilar, M Pérez-Mendoza, M Olguín-Martínez, R Hernández-Muñoz, G A Báez-Ruiz, M Díaz-Muñoz
Daytime restricted feeding (2 h of food access from 12.00 to 14.00 hours for 3 weeks) is an experimental protocol that modifies the relationship between metabolic networks and the circadian molecular clock. The precise anatomical locus that controls the biochemical and physiological adaptations to optimise nutrient use is unknown. We explored the changes in liver oxidative lipid handling, such as β-oxidation and its regulation, as well as adaptations in the lipoprotein profile. It was found that daytime restricted feeding promoted an elevation of circulating ketone bodies before mealtime, an altered hepatic daily rhythmicity of 14CO2 production from radioactive palmitic acid, and an up-regulation of the fatty acid oxidation activators, the α-subunit of AMP-activated protein kinase (AMPK), the deacetylase silent mating type information regulation homolog 1, and the transcriptional factor PPARγ-1α coactivator...
May 9, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28481031/interleukin-6-trans-signaling-regulates-basal-synaptic-transmission-and-sensitivity-to-pentylenetetrazole-induced-seizures-in-mice
#7
Roberto Cuevas-Olguin, Eric Esquivel-Rendon, Jorge Vargas-Mireles, Francisco Garcias-Oscos, Marcela Miranda-Morales, Humberto Salgado, Stefan Rose-John, Marco Atzori
The pro-inflammatory cytokine interleukin 6 (IL-6) interacts with the central nervous system in a largely unknown manner. We used a genetically modified mouse strain (GFAP-sgp130Fc, TG) and wild type (WT) mice to determine whether IL-6 trans-signaling contributes to basal properties of synaptic transmission. Postsynaptic currents (PSCs) were studied by patch-clamp recording in cortical layer 5 of a mouse prefrontal cortex brain slice preparation. TG and WT animals displayed differences mainly (but not exclusively) in excitatory synaptic responses...
May 8, 2017: Synapse
https://www.readbyqxmd.com/read/28479956/a-single-zidovudine-azt-administration-delays-hepatic-cell-proliferation-by-altering-oxidative-state-in-the-regenerating-rat-liver
#8
Armando Butanda-Ochoa, Diego Rolando Hernández-Espinosa, Marisela Olguín-Martínez, Lourdes Sánchez-Sevilla, Mario R Rodríguez, Benito Chávez-Rentería, Alberto Aranda-Fraustro, Rolando Hernández-Muñoz
The 3'-azido-3'-deoxythymidine or Zidovudine (AZT) was the first antiretroviral drug used in the treatment of HIV patients, which has good effectiveness but also hepatotoxic side effects that include cell cycle arrest and oxidative/nitrative mitochondrial damage. Whether such an oxidative damage may affect the proliferative-regenerative capacity of liver remains to be clearly specified at doses commonly used in the clinical practice. In this study, we described the oxidative-proliferative effect of AZT administered at a common clinical dose in rat liver submitted to 70% partial hepatectomy (PH)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28456327/impact-of-vitiligo-on-quality-of-life
#9
M A Morales-Sánchez, M Vargas-Salinas, M L Peralta-Pedrero, M G Olguín-García, F Jurado-Santa Cruz
INTRODUCTION AND OBJECTIVE: Vitiligo is a chronic autoimmune skin disease caused by the destruction of melanocytes. Although quality of life (QOL) in vitiligo has been studied in different countries, it has not yet been investigated in Mexico. The aim of this study was to assess the QOL of Mexican patients with vitiligo. MATERIAL AND METHOD: We conducted a cross-sectional study at the research unit of Centro Dermatológico Dr. Ladislao de la Pascua in Mexico City...
April 26, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28455378/ehmt2-g9a-controls-placental-vascular-maturation-by-activating-the-notch-pathway
#10
Lijun Chi, Abdalla Ahmed, Anna R Roy, Sandra Vuong, Lindsay S Cahill, Laura Caporiccio, John G Sled, Isabella Caniggia, Michael D Wilson, Paul Delgado-Olguin
Defective fetoplacental vascular maturation causes intrauterine growth restriction (IUGR). A transcriptional switch initiates placental maturation where blood vessels elongate. However, cellular mechanisms and regulatory pathways involved are unknown. We show that the histone methyltransferase Ehmt2, also known as G9a, activates the Notch pathway to promote placental vascular maturation. Placental vasculature from embryos with G9a-deficient endothelial progenitor cells failed to expand due to decreased endothelial cell proliferation and increased trophoblast proliferation...
April 28, 2017: Development
https://www.readbyqxmd.com/read/28426898/improving-myoblast-differentiation-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-scaffolds
#11
Phammela N Abarzúa-Illanes, Cristina Padilla, Andrea Ramos, Mauricio Isaacs, Jorge Ramos-Grez, Hugo C Olguín, Loreto M Valenzuela
Polymer scaffolds are used as an alternative to support tissue regeneration when it does not occur on its own. Cell response on polymer scaffolds is determined by factors such as polymer composition, topology, and the presence of other molecules. We evaluated the cellular response of murine skeletal muscle myoblasts on aligned or unaligned fibers obtained by electrospinning poly(ε-caprolactone) (PCL), and blends with poly(lactic-co-glycolic acid) (PLGA) or decorin, a proteoglycan known to regulate myogenesis...
April 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28386542/mechanical-control-of-myotendinous-junction-formation-and-tendon-differentiation-during-development
#12
REVIEW
Mauricio Valdivia, Franco Vega-Macaya, Patricio Olguín
The development of the musculoskeletal system is a great model to study the interplay between chemical and mechanical inter-tissue signaling in cell adhesion, tissue morphogenesis and differentiation. In both vertebrates and invertebrates (e.g., Drosophila melanogaster) the formation of muscle-tendon interaction generates mechanical forces which are required for myotendinous junction maturation and tissue differentiation. In addition, these forces must be withstood by muscles and tendons in order to prevent detachment from each other, deformation or even losing their integrity...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28374582/detection-of-enzyme-inhibitors-in-crude-natural-extracts-using-droplet-based-microfluidics-coupled-to-hplc
#13
Abraham Ochoa, Enrique Álvarez-Bohórquez, Eduardo Castillero, Luis F Olguin
Natural product screening for new bioactive compounds can greatly benefit from low reagents consumption and high throughput capacity of droplet-based microfluidic systems. However, the creation of large droplet libraries in which each droplet carries a different compound is a challenging task. A possible solution is to use an HPLC coupled to a droplet generating microfluidic device to sequentially encapsulate the eluting compounds. In this work we demonstrate the feasibility of carrying out enzyme inhibiting assays inside nanoliter droplets with the different components of a natural crude extract after being separated by a coupled HPLC column...
April 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28373872/type-i-interferon-gene-response-is-increased-in-early-and-established-rheumatoid-arthritis-and-correlates-with-autoantibody-production
#14
Julio E Castañeda-Delgado, Yadira Bastián-Hernandez, Noe Macias-Segura, David Santiago-Algarra, Jose D Castillo-Ortiz, Ana L Alemán-Navarro, Pedro Martínez-Tejada, Leonor Enciso-Moreno, Yolanda Garcia-De Lira, Diana Olguín-Calderón, Leendert A Trouw, Cesar Ramos-Remus, Jose A Enciso-Moreno
BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory debilitating disease that affects the joints in the early and productive phases of an individual's life. Several cytokines have been linked to the disease pathogenesis and are known to contribute to the inflammatory state characteristic of RA. The participation of type I interferon (IFN) in the pathogenesis of the disease has been already described as well as the identity of the genes that are regulated by this molecule, which are collectively known as the type I IFN signature...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28361744/admission-handgrip-strength-predicts-functional-decline-in-hospitalized-patients
#15
Thiare Olguín, Daniel Bunout, María Pía de la Maza, Gladys Barrera, Sandra Hirsch
PROBLEM: Up to 35% of hospitalized patients may experience functional decline during or after hospitalization. Subjective Global Assessment (SGA) and handgrip strength at admission, have been proposed as simple and accessible tools to predict functional decline, but there are few studies in hospitalized patients to confirm these findings. OBJECTIVE: To assess the predictive value of handgrip strength at hospital admission, on functional decline after 30 days. METHODS: 125 non-critical patients hospitalized for medical and surgical conditions, were studied in El Pino hospital in Santiago, Chile...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28342739/supervised-physical-therapy-vs-home-exercise-program-for-patients-with-distal-radius-fracture-a-single-blind-randomized-clinical-study
#16
Héctor Gutiérrez-Espinoza, David Rubio-Oyarzún, Cristian Olguín-Huerta, Rodrigo Gutiérrez-Monclus, Sebastian Pinto-Concha, Gonzalo Gana-Hervias
STUDY DESIGN: Randomized clinical study. INTRODUCTION: Supervised physical therapy (PT) and home exercise programs (HEPs) are frequently used in the rehabilitation of patients with distal radius fracture (DRF). However, there is no consensus as to whether unsupervised HEP provides comparable benefits to those achieved by supervised PT. PURPOSE OF THE STUDY: To compare the improvements in pain and functional status between a supervised PT program and unsupervised HEP in DRF patients older than 60 years...
March 22, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28319719/year-round-phytofiltration-lagoon-assessment-using-pistia-stratiotes-within-a-pilot-plant-scale-biorefinery
#17
Eugenia J Olguín, Daniel A García-López, Ricardo E González-Portela, Gloria Sánchez-Galván
Phytofiltration lagoons are phytoremediation technologies suitable for tropical and sub-tropical regions requiring cost-effective and echo-friendly technologies. A biorefinery of fourth generation has been implemented at pilot plant level in Xalapa, Mexico, and the phytofiltration lagoon, being the first module for provision of treated water and plant biomass for biofuel production plays a key role. The aim of this work was to evaluate the performance of such phytofiltration lagoon with a working volume of 13,000 L for the removal of nutrients from an urban river polluted with domestic wastewater and the biomass productivity of the macrophyte Pistia stratiotes, during five different experimental periods, comprising 42 days each one...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28288228/-upper-limb-functional-assessment-scale-for-children-with-duchenne-muscular-dystrophy-and-spinal-muscular-atrophy
#18
Raúl G Escobar, Nayadet Lucero, Carmen Solares, Victoria Espinoza, Odalie Moscoso, Polín Olguín, Karin T Muñoz, Ricardo Rosas
Duchenne muscular dystrophy (DMD) and Spinal muscular atrophy (SMA) causes significant disability and progressive functional impairment. Readily available instruments that assess functionality, especially in advanced stages of the disease, are required to monitor the progress of the disease and the impact of therapeutic interventions. OBJECTIVE: To describe the development of a scale to evaluate upper limb function (UL) in patients with DMD and SMA, and describe its validation process, which includes self-training for evaluators...
February 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28283314/the-progetto-nazionale-emorragia-digestiva-pned-system-vs-the-rockall-score-as-mortality-predictors-in-patients-with-nonvariceal-upper-gastrointestinal-bleeding-a-multicenter-prospective-study
#19
R Contreras-Omaña, J A Alfaro-Reynoso, C E Cruz-Chávez, A Velarde-Ruiz Velasco, D I Flores-Ramírez, I Romero-Hernández, I Donato-Olguín, X García-Samper, A Bautista-Santos, M Reyes-Bastidas, E Millán-Marín
BACKGROUND: The predictive scale for mortality risk in patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) proposed by Italy's PNED (Progetto Nazionale Emorragia Digestiva) group has not been validated in Latin America since its original publication. AIM: To compare the PNED system and the Rockall score as mortality predictors in patients hospitalized for NVUGIB. MATERIAL AND METHODS: A multicenter, prospective, cross-sectional, analytic study was conducted that recruited patients diagnosed with nonvariceal upper gastrointestinal bleeding within the time frame of 2011 to 2015...
March 7, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28254056/cadmium-sorption-by-sodium-and-thiourea-modified-zeolite-rich-tuffs
#20
Perfecto Barragán P, M Guadalupe Macedo M, Maria T Olguín
No abstract text is available yet for this article.
February 2017: Journal of Environmental Sciences (China)
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