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https://www.readbyqxmd.com/read/28817955/redox-signaling-mechanisms-in-nervous-system-development
#1
Mauricio Olguín-Albuerne, Julio Morán
SIGNIFICANCE: Numerous studies have demonstrated the actions of reactive oxygen species (ROS) as regulators of several physiological processes. Here we discuss how the redox signaling mechanisms operate to control different processes such as neuronal differentiation, oligodendrocyte differentiation, dendritic growth, and axonal growth. Recent Advances: Redox homeostasis regulates the physiology of neural stem cells (NSCs). Notably, the neuronal differentiation process of NSCs is determined by a change towards an oxidative metabolism, increased levels of mitochondrial ROS, increased activity of NOX enzymes, decreased levels of Nrf2, and a differential regulation of different redoxins...
August 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28791664/pharmacokinetics-of-sildenafil-in-children-with-pulmonary-arterial-hypertension
#2
Hugo Juárez Olguín, Hector Osnaya Martínez, Carmen Flores Pérez, Blanca Ramírez Mendiola, Liliana Rivera Espinosa, Juan Luis Chávez Pacheco, Janett Flores Pérez, Ignacio Mora Magaña
BACKGROUND: Recently, sildenafil was introduced to treat pulmonary arterial hypertension (PAH); however, there are currently few studies on the pharmacokinetics of sildenalfil in children. Therefore, we aimed to carry out a pharmacokinetic study of sildenafil in children with PAH using a single dose. METHODS: Twelve children diagnosed with PAH, consisting of with ten males and two females, were recruited for the study after obtaining written consent from their parents or guardians...
August 8, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28744067/helminth-products-potently-modulate-experimental-autoimmune-encephalomyelitis-by-downregulating-neuroinflammation-and-promoting-a-suppressive-microenvironment
#3
Alberto N Peón, Yadira Ledesma-Soto, Jonadab E Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I Terrazas
A negative correlation between the geographical distribution of autoimmune diseases and helminth infections has been largely associated in the last few years with a possible role for such type of parasites in the regulation of inflammatory diseases, suggesting new pathways for drug development. However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS). The immunomodulatory activities of Taenia crassiceps excreted/secreted products (TcES) that may suppress EAE development were sought for...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28714392/natural-steroids-and-androgen-antagonists-used-as-neuroprotectives-in-common-neurological-disorders
#4
David Calderon Guzman, Hugo Juarez Olguin, Ernestina Hernandez Garcia, Monica Punzo Soto, Mayra Santillan Garcia, Gerardo Barragan Mejia
Multiple classes of natural products, such as antiandrogens or steroids have been used as antioxidants and anti-inflammatory treatments in neurodegenerative diseases. This paper aims to review current knowledge on these substances and their possible relationship with free radicals as an alternative therapy and prevention of common neurological disorders. An exhaustive review of the neurochemical mechanisms of these substances in the central nervous system of humans and animal models has yet to be undertaken in the literature, particularly regarding their importance and increasing use...
July 14, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28622645/statistical-equivalence-of-prediction-models-of-the-soil-sorption-coefficient-obtained-using-different-log-p-algorithms
#5
Carlos José Maria Olguin, Silvio César Sampaio, Ralpho Rinaldo Dos Reis
The soil sorption coefficient normalized to the organic carbon content (Koc) is a physicochemical parameter used in environmental risk assessments and in determining the final fate of chemicals released into the environment. Several models for predicting this parameter have been proposed based on the relationship between log Koc and log P. The difficulty and cost of obtaining experimental log P values led to the development of algorithms to calculate these values, some of which are free to use. However, quantitative structure-property relationship (QSPR) studies did not detail how or why a particular algorithm was chosen...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28609577/cerebrolysin-prevents-deficits-in-social-behavior-repetitive-conduct-and-synaptic-inhibition-in-a-rat-model-of-autism
#6
Roberto Cuevas-Olguin, Swagata Roychowdhury, Anwesha Banerjee, Francisco Garcia-Oscos, Eric Esquivel-Rendon, María Elena Bringas, Michael P Kilgard, Gonzalo Flores, Marco Atzori
Autism spectrum disorder (ASD) is a syndrome of diverse neuropsychiatric diseases of growing incidence characterized by repetitive conduct and impaired social behavior and communication for which effective pharmacological treatment is still unavailable. While the mechanisms and etiology of ASD are still unknown, a consensus is emerging about the synaptic nature of the syndrome, suggesting a possible avenue for pharmacological treatment with synaptogenic compounds. The peptidic mixture cerebrolysin (CBL) has been successfully used during the last three decades in the treatment of stroke and neurodegenerative disease...
June 13, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28604594/hemi-synthesis-and-anti-oomycete-activity-of-analogues-of-isocordoin
#7
Beatriz Escobar, Iván Montenegro, Joan Villena, Enrique Werner, Patricio Godoy, Yusser Olguín, Alejandro Madrid
An efficient synthesis of a series of 4'-oxyalkyl-isocordoin analogues (2-8) is reported for the first time. Their structures were confirmed by ¹H-NMR, (13)C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively...
June 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28539708/assessment-of-mexican-arnica-heterotheca-inuloides-cass-and-rosemary-rosmarinus-officinalis-extracts-on-dopamine-and-selected-biomarkers-of-oxidative-stress-in-stomach-and-brain-of-salmonella-typhimurium-infected-rats
#8
David Calderón Guzmàn, Maribel Ortiz Herrera, Norma Osnaya Brizuela, Gerardo Barragàn Mejía, Ernestina Hernàndez García, Hugo Juàrez Olguín, Armando Valenzuela Peraza, Norma Labra Ruíz, Daniel Santamaría Del Angel
BACKGROUND: The effects of some natural products on dopamine (DA) and 5-hydroxyindole acetic acid (5-HIAA) in brain of infected models are still unclear. OBJECTIVE: The purpose of this study was to measure the effect of Mexican arnica/rosemary (MAR) water extract and oseltamivir on both biogenic amines and some oxidative biomarkers in the brain and stomach of young rats under infection condition. METHODS: Female Wistar rats (weight 80 g) in the presence of MAR or absence (no-MAR) were treated as follows: group 1, buffer solution (controls); oseltamivir (100 mg/kg), group 2; culture of Salmonella typhimurium (S...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28535183/time-caloric-restriction-inhibits-the-neoplastic-transformation-of-cirrhotic-liver-in-rats-treated-with-diethylnitrosamine
#9
Christian Molina-Aguilar, María de Jesús Guerrero-Carrillo, Jesús Javier Espinosa-Aguirre, Sitlali Olguin-Reyes, Thania Castro-Belio, Olivia Vázquez-Martínez, Julieta Berenice Rivera-Zavala, Mauricio Díaz-Muñoz
Hepatocellular cancer is the most common type of primary liver cancer. Cirrhosis is the main risk factor that generates this malady. It has been proven that caloric restriction protocols and restricted feeding schedules are protective in experimental carcinogenic models. We tested the influence of a time-caloric restriction protocol (2 h of food access during the daytime for 18 weeks) in an experimental model of cirrhosis-hepatocarcinoma produced by weekly administration of diethylnitrosamine. Our results indicate that time-caloric restriction reduced hepatomegaly and prevented the increase in blood leukocytes promoted by diethylnitrosamine...
May 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28533272/chimeric-pd-1-28-receptor-upgrades-low-avidity-t-cells-and-restores-effector-function-of-tumor-infiltrating-lymphocytes-for-adoptive-cell-therapy
#10
Ramona Schlenker, Luis Felipe Olguín-Contreras, Matthias Leisegang, Julia Schnappinger, Anja Disovic, Svenja Rühland, Peter J Nelson, Heinrich Leonhardt, Hartmann Harz, Susanne Wilde, Dolores J Schendel, Wolfgang Uckert, Gerald Willimsky, Elfriede Noessner
Inherent intermediate- to low-affinity T-cell receptors (TCR) that develop during the natural course of immune responses may not allow sufficient activation for tumor elimination, making the majority of T cells suboptimal for adoptive T-cell therapy (ATT). TCR affinity enhancement has been implemented to provide stronger T-cell activity but carries the risk of creating undesired cross-reactivity leading to potential serious adverse effects in clinical application. We demonstrate here that engineering of low-avidity T cells recognizing a naturally processed and presented tumor-associated antigen with a chimeric PD-1:28 receptor increases effector function to levels seen with high-avidity T cells of identical specificity...
May 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28521531/removal-of-co-by-carbonaceous-material-obtained-through-solution-combustion-of-tamarind-shell
#11
H López-González, J Serrano-Gómez, M T Olguín, J Hernández-López, S Bulbulian
New carbonaceous materials were obtained through solution combustion process of tamarind shell in the presence of urea and ammonium nitrate, and all of them were tested for Co removal. The effect of temperature (from 600°C to 1000°C) and water volume on surface texture of carbonaceous material and its adsorptive capacity was evaluated. Scanning electron microscope, FTIR, XRD and BET model were used to characterize the obtained carbonaceous material before applying for the removal of cobalt. The point of zero charge was also determined...
May 19, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28492284/inhibition-of-corticotropin-releasing-hormone-receptor-1-and-activation-of-receptor-2-protect-against-colonic-injury-and-promote-epithelium-repair
#12
Bo Li, Carol Lee, Tali Filler, Alison Hock, Richard You Wu, Qi Li, Shigang Chen, Yuhki Koike, Wan Ip, Lijun Chi, Elke Zani-Ruttenstock, Pekka Määttänen, Tanja Gonska, Paul Delgado-Olguin, Augusto Zani, Philip M Sherman, Agostino Pierro
Maternal separation (MS) in neonates can lead to intestinal injury. MS in neonatal mice disrupts mucosal morphology, induces colonic inflammation and increases trans-cellular permeability. Several studies indicate that intestinal epithelial stem cells are capable of initiating gut repair in a variety of injury models but have not been reported in MS. The pathophysiology of MS-induced gut injury and subsequent repair remains unclear, but communication between the brain and gut contribute to MS-induced colonic injury...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28482939/daytime-restricted-feeding-modifies-the-daily-regulation-of-fatty-acid-%C3%AE-oxidation-and-the-lipoprotein-profile-in-rats
#13
J B Rivera-Zavala, C Molina-Aguilar, M Pérez-Mendoza, M Olguín-Martínez, R Hernández-Muñoz, G A Báez-Ruiz, M Díaz-Muñoz
Daytime restricted feeding (2 h of food access from 12.00 to 14.00 hours for 3 weeks) is an experimental protocol that modifies the relationship between metabolic networks and the circadian molecular clock. The precise anatomical locus that controls the biochemical and physiological adaptations to optimise nutrient use is unknown. We explored the changes in liver oxidative lipid handling, such as β-oxidation and its regulation, as well as adaptations in the lipoprotein profile. It was found that daytime restricted feeding promoted an elevation of circulating ketone bodies before mealtime, an altered hepatic daily rhythmicity of 14CO2 production from radioactive palmitic acid, and an up-regulation of the fatty acid oxidation activators, the α-subunit of AMP-activated protein kinase (AMPK), the deacetylase silent mating type information regulation homolog 1, and the transcriptional factor PPARγ-1α coactivator...
April 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28481031/interleukin-6-trans-signaling-regulates-basal-synaptic-transmission-and-sensitivity-to-pentylenetetrazole-induced-seizures-in-mice
#14
Roberto Cuevas-Olguin, Eric Esquivel-Rendon, Jorge Vargas-Mireles, Francisco Garcia-Oscos, Marcela Miranda-Morales, Humberto Salgado, Stefan Rose-John, Marco Atzori
The pro-inflammatory cytokine interleukin 6 (IL-6) interacts with the central nervous system in a largely unknown manner. We used a genetically modified mouse strain (GFAP-sgp130Fc, TG) and wild type (WT) mice to determine whether IL-6 trans-signaling contributes to basal properties of synaptic transmission. Postsynaptic currents (PSCs) were studied by patch-clamp recording in cortical layer 5 of a mouse prefrontal cortex brain slice preparation. TG and WT animals displayed differences mainly (but not exclusively) in excitatory synaptic responses...
May 8, 2017: Synapse
https://www.readbyqxmd.com/read/28479956/a-single-zidovudine-azt-administration-delays-hepatic-cell-proliferation-by-altering-oxidative-state-in-the-regenerating-rat-liver
#15
Armando Butanda-Ochoa, Diego Rolando Hernández-Espinosa, Marisela Olguín-Martínez, Lourdes Sánchez-Sevilla, Mario R Rodríguez, Benito Chávez-Rentería, Alberto Aranda-Fraustro, Rolando Hernández-Muñoz
The 3'-azido-3'-deoxythymidine or Zidovudine (AZT) was the first antiretroviral drug used in the treatment of HIV patients, which has good effectiveness but also hepatotoxic side effects that include cell cycle arrest and oxidative/nitrative mitochondrial damage. Whether such an oxidative damage may affect the proliferative-regenerative capacity of liver remains to be clearly specified at doses commonly used in the clinical practice. In this study, we described the oxidative-proliferative effect of AZT administered at a common clinical dose in rat liver submitted to 70% partial hepatectomy (PH)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28456327/impact-of-vitiligo-on-quality-of-life
#16
M A Morales-Sánchez, M Vargas-Salinas, M L Peralta-Pedrero, M G Olguín-García, F Jurado-Santa Cruz
INTRODUCTION AND OBJECTIVE: Vitiligo is a chronic autoimmune skin disease caused by the destruction of melanocytes. Although quality of life (QOL) in vitiligo has been studied in different countries, it has not yet been investigated in Mexico. The aim of this study was to assess the QOL of Mexican patients with vitiligo. MATERIAL AND METHOD: We conducted a cross-sectional study at the research unit of Centro Dermatológico Dr. Ladislao de la Pascua in Mexico City...
April 26, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28455378/ehmt2-g9a-controls-placental-vascular-maturation-by-activating-the-notch-pathway
#17
Lijun Chi, Abdalla Ahmed, Anna R Roy, Sandra Vuong, Lindsay S Cahill, Laura Caporiccio, John G Sled, Isabella Caniggia, Michael D Wilson, Paul Delgado-Olguin
Defective fetoplacental vascular maturation causes intrauterine growth restriction (IUGR). A transcriptional switch initiates placental maturation where blood vessels elongate. However, cellular mechanisms and regulatory pathways involved are unknown. We show that the histone methyltransferase Ehmt2, also known as G9a, activates the Notch pathway to promote placental vascular maturation. Placental vasculature from embryos with G9a-deficient endothelial progenitor cells failed to expand due to decreased endothelial cell proliferation and increased trophoblast proliferation...
April 28, 2017: Development
https://www.readbyqxmd.com/read/28426898/improving-myoblast-differentiation-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-scaffolds
#18
Phammela N Abarzúa-Illanes, Cristina Padilla, Andrea Ramos, Mauricio Isaacs, Jorge Ramos-Grez, Hugo C Olguín, Loreto M Valenzuela
Polymer scaffolds are used as an alternative to support tissue regeneration when it does not occur on its own. Cell response on polymer scaffolds is determined by factors such as polymer composition, topology, and the presence of other molecules. We evaluated the cellular response of murine skeletal muscle myoblasts on aligned or unaligned fibers obtained by electrospinning poly(ε-caprolactone) (PCL), and blends with poly(lactic-co-glycolic acid) (PLGA) or decorin, a proteoglycan known to regulate myogenesis...
April 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28386542/mechanical-control-of-myotendinous-junction-formation-and-tendon-differentiation-during-development
#19
REVIEW
Mauricio Valdivia, Franco Vega-Macaya, Patricio Olguín
The development of the musculoskeletal system is a great model to study the interplay between chemical and mechanical inter-tissue signaling in cell adhesion, tissue morphogenesis and differentiation. In both vertebrates and invertebrates (e.g., Drosophila melanogaster) the formation of muscle-tendon interaction generates mechanical forces which are required for myotendinous junction maturation and tissue differentiation. In addition, these forces must be withstood by muscles and tendons in order to prevent detachment from each other, deformation or even losing their integrity...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28374582/detection-of-enzyme-inhibitors-in-crude-natural-extracts-using-droplet-based-microfluidics-coupled-to-hplc
#20
Abraham Ochoa, Enrique Álvarez-Bohórquez, Eduardo Castillero, Luis F Olguin
Natural product screening for new bioactive compounds can greatly benefit from low reagents consumption and high throughput capacity of droplet-based microfluidic systems. However, the creation of large droplet libraries in which each droplet carries a different compound is a challenging task. A possible solution is to use an HPLC coupled to a droplet generating microfluidic device to sequentially encapsulate the eluting compounds. In this work we demonstrate the feasibility of carrying out enzyme inhibiting assays inside nanoliter droplets with the different components of a natural crude extract after being separated by a coupled HPLC column...
April 17, 2017: Analytical Chemistry
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