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cholestasis pregnancy and newborn

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https://www.readbyqxmd.com/read/27882439/obstetric-and-perinatal-outcome-of-babies-born-from-sperm-selected-by-macs-from-a-randomized-controlled-trial
#1
Laura Romany, Nicolas Garrido, Ana Cobo, Belen Aparicio-Ruiz, Vicente Serra, Marcos Meseguer
PURPOSE: The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial. METHODS: This is a two-arm, unicentric, prospective, randomized, and triple-blinded trial and has a total of 237 infertile couples, between October 2010 and January 2013. A total of 65 and 66 newborns from MACS and control group, respectively, were described...
November 23, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/26645539/post-term-pregnancy-is-an-independent-risk-factor-for-neonatal-morbidity-even-in-low-risk-singleton-pregnancies
#2
Nehama Linder, Liran Hiersch, Elana Fridman, Gil Klinger, Daniel Lubin, Franck Kouadio, Nir Melamed
OBJECTIVE: To determine the independent association of post-term pregnancy with neonatal outcome in low-risk newborns. DESIGN: Retrospective cohort. SETTING: Tertiary university-affiliated medical centre. PATIENTS: All newborns of low-risk singleton pregnancies born at 39+0 to 44+0 weeks' gestation over a 5-year period. EXCLUSION CRITERIA: multiple gestation, maternal hypertensive disorder, diabetes or cholestasis, placental abruption or intrapartum fever (>38°C), small for gestational age (<10th centile) and major congenital or chromosomal anomalies...
December 8, 2015: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26496681/severe-case-of-fetal-hemolytic-disease-caused-by-anti-c-w-requiring-serial-intrauterine-transfusions-complicated-by-pancytopenia-and-cholestasis
#3
Susanne Macher, Thomas Wagner, Konrad Rosskopf, Friedrich Reiterer, Bence Csapo, Peter Schlenke, Philipp Klaritsch
BACKGROUND: Anti-C(w) are rarely found as a source for severe fetal and neonatal hemolytic diseases. We report a case with serial intrauterine transfusions complicated by pancytopenia and cholestasis in the neonatal period. CASE REPORT: A 37-year-old woman revealed anti-C(w) with a titer of 512 in her fourth pregnancy. The fetus developed fetal anemia and a severe hydrops requiring three intrauterine red blood cell (RBC) transfusions. After birth at 33 + 0 weeks the newborn presented only transfused RBCs and suffered from anemia, thrombocytopenia, leukopenia, and a cholestatic liver disease...
January 2016: Transfusion
https://www.readbyqxmd.com/read/26447743/risk-of-pregnancy-complications-in-relation-to-maternal-prepregnancy-body-mass-index-population-based-study-from-finland-2006-10
#4
Johanna Metsälä, Beata Stach-Lempinen, Mika Gissler, Johan G Eriksson, Saila Koivusalo
BACKGROUND: Overweight and obesity are well-known risk factors for several pregnancy-related complications, but the nature of the association between maternal adiposity and these complications has been less studied. The objective of the present study was to examine the shape and the magnitude of the association between maternal prepregnancy body mass index and the risk of gestational diabetes, pre-eclampsia of different severity, gestational hypertension, and obstetric cholestasis among Finnish primiparae women...
January 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/26416771/maternal-bile-acid-transporter-deficiency-promotes-neonatal-demise
#5
Yuanyuan Zhang, Fei Li, Yao Wang, Aaron Pitre, Zhong-Ze Fang, Matthew W Frank, Christopher Calabrese, Kristopher W Krausz, Geoffrey Neale, Sharon Frase, Peter Vogel, Charles O Rock, Frank J Gonzalez, John D Schuetz
Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse neonatal survival and is estimated to impact between 0.4 and 5% of pregnancies worldwide. Here we show that maternal cholestasis (due to Abcb11 deficiency) produces neonatal death among all offspring within 24 h of birth due to atelectasis-producing pulmonary hypoxia, which recapitulates the neonatal respiratory distress of human ICP. Neonates of Abcb11-deficient mothers have elevated pulmonary bile acids and altered pulmonary surfactant structure...
September 29, 2015: Nature Communications
https://www.readbyqxmd.com/read/26350006/-prediction-model-of-fetal-meconium-stained-amniotic-fluid-in-re-pregnant-women-with-intrahepatic-cholestasis-of-pregnancy
#6
Ling-fei He, Yun Zhao, Zheng-ping Wang
OBJECTIVE: To establish a prediction model of fetal meconium-stained amniotic fluid in re-pregnant women with intrahepatic cholestasis of pregnancy (ICP). METHODS: Clinical data of 180 re-pregnant women with ICP delivering in Women's Hospital, Zhejiang University School of Medicine between January 2009 to August 2014 were collected. An artificial neural network model (ANN) for risk evaluation of fetal meconium-stained fluid was established and assessed. RESULTS: The sensitivity, specificity and accuracy of ANN for predicting fetal meconium-stained fluid were 68...
May 2015: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/26298297/-hospital-admissions-due-to-cyanosis-episodes-in-newborns-with-gestational-age-of-34-weeks-or-more
#7
C Paulina Casanueva, R Javier Cifuentes
OBJECTIVES: A retrospective study was performed between January 2007 and December 2012 to assess the admission rates of newborns due to episodes of cyanosis PATIENTS AND METHOD: Retrospective study that included all the newborns hospitalized with episodes of cyanosis between January 2007 and December 2012. In them were employed two study protocols that considered first and second line tests, the latter in view of recurrence of events. The first line protocol considered general biochemical tests, chest x-ray and echocardiography in selected cases, while the second line protocol included electroencephalogram, electrocardiogram, nuclear magnetic resonance of the brain, expanded metabolic screening, pyruvic acid, lactic acid, and in case of seizures, cytochemical, and culture of cerebrospinal fluid (CSF) and PCR (polymerase chain reaction) for herpes...
July 2015: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/26281345/intrahepatic-cholestasis-of-pregnancy-may-lead-to-low-birth-weight
#8
Ibrahim Uyar, Ibrahim Gülhan, Deniz Öztekin, Cenk Gezer, Atalay Ekin, Seçil Karaca Kurtulmuş, Mehmet Özeren
BACKGROUND/AIM: To evaluate patients hospitalized in our clinic in the last 5 years with the diagnosis of intrahepatic cholestasis of pregnancy (ICP). MATERIALS AND METHODS: One hundred and fifty patients hospitalized with a diagnosis of ICP between January 2008 and May 2013 were evaluated retrospectively and age, week at diagnosis, gestational age at delivery, period between diagnosis and delivery, fetal weight, transaminases, and coagulation parameters were recorded...
2015: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/26215400/intrahepatic-cholestasis-of-pregnancy-observational-study-of-the-treatment-with-low-dose-ursodeoxycholic-acid
#9
Titta Joutsiniemi, Susanna Timonen, Maria Linden, Pia Suvitie, Ulla Ekblad
BACKGROUND: To exam the biochemical, obstetric management and pregnancy outcome in women with intrahepatic cholestasis of pregnancy (ICP) and treatment with ursodeoxycholic acid (UDCA). METHODS: Pregnancy outcome in patients with ICP (N = 307) was studied and patients treated with UDCA (N = 208) vs. no UDCA were compared. The data of the antenatal visits, deliveries and neonatal outcome of 307 pregnancies with ICP was collected from the hospital computerized delivery room log book...
2015: BMC Gastroenterology
https://www.readbyqxmd.com/read/26071912/predictors-of-adverse-neonatal-outcomes-in-intrahepatic-cholestasis-of-pregnancy
#10
MULTICENTER STUDY
Tetsuya Kawakita, Laura I Parikh, Patrick S Ramsey, Chun-Chih Huang, Alexander Zeymo, Miguel Fernandez, Samuel Smith, Sara N Iqbal
OBJECTIVE: We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). STUDY DESIGN: This study was a multicenter retrospective cohort study of all women diagnosed with ICP across 5 hospital facilities from January 2009 through December 2014. Obstetric and neonatal complications were evaluated according to total bile acid (TBA) level. Multivariable logistic regression models were developed to evaluate predictors of composite neonatal outcome (neonatal intensive care unit admission, hypoglycemia, hyperbilirubinemia, respiratory distress syndrome, transient tachypnea of the newborn, mechanical ventilation use, oxygen by nasal cannula, pneumonia, and stillbirth)...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25980109/the-deadly-itch-how-my-midwives-saved-my-babies-lives
#11
Kim Gallina Viscio
No abstract text is available yet for this article.
2014: Midwifery Today with International Midwife
https://www.readbyqxmd.com/read/25947393/obstetrical-disease-spectrum-in-china-an-epidemiological-study-of-111-767-cases-in-2011
#12
Xiao-Lin Luo, Wei-Yuan Zhang
BACKGROUND: No national research on maternal and fetal complications and outcomes has been carried out in the mainland of China in recent years. This study was to provide a scientific basis for better control of obstetrical and neonatal diseases and better allocation of medical resources by analyzing the epidemiological characteristics of obstetrical diseases in the mainland of China. METHODS: Hospitalized obstetrical cases from 19 tertiary and 20 secondary hospitals in 14 provinces (nationally representative) during the period January 1, 2011 to December 31, 2011 were randomly selected...
May 5, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/25864296/successful-management-of-discordant-alobar-holoprosencephaly-in-monochorionic-diamniotic-twins-with-normal-karyotype-a-case-report
#13
J Zhang, T Yang, X Wang, H Yu
Holoprosencephaly (HPE), a complex brain malformation resulting from incomplete cleavage of the prosencephalon into distinct cerebral hemispheres, is rare in newborns. Two preterm male neonates were born at 34 weeks' and five days' gestation in the monochorionic diamniotic twin pregnancy complicated with pre-eclampsia and intrahepatic cholestasis of pregnancy, and one of them was prenatally diagnosed with alobar HPE by ultrasonography with frontal bossing, hydrocephaly, hypotelorism of eyes, flat nasal bridge, macroglossia, and cheilo/palatoschisis at birth...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25772037/intrahepatic-cholestasis-of-pregnancy-and-cancer-immune-mediated-and-cardiovascular-diseases-a-population-based-cohort-study
#14
MULTICENTER STUDY
Elisabeth A Wikström Shemer, Olof Stephansson, Marcus Thuresson, Malin Thorsell, Jonas F Ludvigsson, Hanns-Ulrich Marschall
BACKGROUND & AIMS: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease in pregnancy. It is associated with hepatobiliary diseases that might predispose to cancer and also with gestational diabetes and preeclampsia. In this study, we examined associations between ICP and cancer, and immune-mediated and cardiovascular diseases. METHODS: By linking the Swedish Medical Birth Register and the Swedish Patient Register, we identified 11,388 women with ICP and 113,893 matched women without ICP who gave birth between 1973 and 2009...
August 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25720981/clinical-value-of-maternal-bile-acid-quantification-in-intrahepatic-cholestasis-of-pregnancy-as-an-adverse-perinatal-outcome-predictor
#15
Jose Garcia-Flores, Marina Cañamares, Mireia Cruceyra, Ainhoa Garicano, Mercedes Espada, Ana Lopez, Ines Tamarit
AIMS: To evaluate the correlation between perinatal outcome and bile acid levels in intrahepatic cholestasis of pregnancy (ICP), and to evaluate variations in the mean bile acid level when stratifying by maternal and perinatal factors. A comparison between mild and severe ICP was made. METHODS: A prospective observational study was performed in pregnant patients who underwent blood tests for bile acids due to persistent pruritus. Based on bile acid levels, maternal and neonatal data were obtained and were compared between patients presenting with ICP and gestational pruritus (normal bile acid level)...
2015: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/25687562/the-risk-of-infant-and-fetal-death-by-each-additional-week-of-expectant-management-in-intrahepatic-cholestasis-of-pregnancy-by-gestational-age
#16
Anela Puljic, Elissa Kim, Jessica Page, Tania Esakoff, Brian Shaffer, Daphne Y LaCoursiere, Aaron B Caughey
OBJECTIVE: The objective of the study was to characterize the risk of infant and fetal death by each additional week of expectant management vs immediate delivery in pregnancies complicated by cholestasis. STUDY DESIGN: This was a retrospective cohort study of 1,604,386 singleton, nonanomalous pregnancies of women between 34 and 40 weeks' gestation with and without intrahepatic cholestasis of pregnancy (ICP) in the state of California during the years of 2005-2008...
May 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25633496/impact-of-parenteral-fat-composition-on-cholestasis-in-preterm-infants
#17
Jonas Teng, Henrik Arnell, Kajsa Bohlin, Antal Nemeth, Björn Fischler
OBJECTIVES: Parenteral nutrition-associated liver disease (PNALD) is frequently detected in neonatal intensive care units. Parenteral lipid emulsion (PLE) content has been implicated in its pathogenesis. We aimed to study the effect on incidence and outcome of PNALD by replacing soy-based PLE with olive oil-based PLE in a population-based group of preterm infants. METHODS: All infants in Stockholm County with gestational age (GA) <30 weeks were included (n = 615)...
June 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25598266/-study-on-the-relationship-between-prenatal-monitoring-index-in-intrahepatic-cholestasis-of-pregnancy-and-perinatal-prognosis
#18
Junling Lu, Jingxia Kuang, Xiaolin Cheng
OBJECTIVE: To investigate the association between prenatal monitoring index in intrahepatic cholestasis of pregnancy and the perinatal prognosis, as well as the characteristics of perinatal situations. METHODS: A retrospective study on the clinical data of 88 cases intrahepatic cholestasis of pregnancy and prognosis that were treated in our hospital from Jan. 2011 to Jan. 2014 was carried out. Relationship between prenatal monitoring index in intrahepatic cholestasis of pregnancy and perinatal prognosis, together with the epidemiological features of infants were analyzed...
November 2014: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/25496231/hepatic-involvement-in-congenital-cytomegalovirus-infection-infrequent-yet-significant
#19
E Bilavsky, M Schwarz, Z Bar-Sever, J Pardo, J Amir
Congenital cytomegalovirus (cCMV) infection can reside in many organ systems; however, the virus has a particular predilection towards inhabiting the reticuloendothelial system, especially the liver. Specific studies focusing only on hepatic involvement in infants with cCMV are lacking. We report our experience with a large cohort of infants treated in our hospital clinic due to cCMV and hepatic involvement. Hepatic involvement was defined either as hepatitis (elevated alanine transaminases (ALT) >80 units/L without cholestatic disease) or cholestatic disease (elevated ALT >80 units/L combined with direct bilirubin >2 mg/dL)...
September 2015: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/25391176/neonatal-lupus-erythematosus-a-20-year-retrospective-study
#20
Srisupalak Singalavanija, Wanida Limpongsanurak, Sutticha Aoongern
OBJECTIVE: To study clinical manifestations, investigations, treatment and outcomes of neonatal lupus erythematosus (NLE) patients and their mothers. MATERIAL AND METHOD: A retrospective descriptive study was performed to review the neonatal lupus erythematosus patients and their mothers at Queen Sirikit National Institute of Child Health during January 1993 to December 2013. The diagnostic criteria required the presence of clinical symptoms plus positive anti-Ro/SSA or anti-La/SSB or both...
June 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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