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vitamin d free radicals

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https://www.readbyqxmd.com/read/28613284/activated-and-micronized-zeolite-in-the-modulation-of-cellular-oxidative-stress-in-mexican-smokers-a-randomized-clinical-trial
#1
Alfonso Atitlán-Gil, Martín M Bretón-de la Loza, José C Jiménez-Ortega, Helen Belefant-Miller, Gabriel Betanzos-Cabrera
BACKGROUND: Activated and micronized zeolites are used as detoxifying agents in humans. Detoxification is attributed to their ability to reduce lipid peroxidation by scavenging free radicals. OBJECTIVE: To evaluate activated and micronized zeolites as modulators of cellular oxidative stress in Mexican smokers without lung diseases. METHODS: Randomized clinical trial. Subjects were randomly divided into three groups: activated and micronized zeolites, n = 29; vitamin E, an accepted antioxidant, n = 29; and maltodextrin as control, n = 27...
May 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28499901/antioxidant-and-anti-inflammatory-nutrient-status-supplementation-and-mechanisms-in-patients-with-schizophrenia
#2
REVIEW
Sumedha Mitra, Radhika Natarajan, Douglas Ziedonis, Xiaoduo Fan
Over 50 million people around the world suffer from schizophrenia, a severe mental illness characterized by misinterpretation of reality. Although the exact causes of schizophrenia are still unknown, studies have indicated that inflammation and oxidative stress may play an important role in the etiology of the disease. Pro-inflammatory cytokines are crucial for normal central nervous development and proper functioning of neural networks and neurotransmitters. Patients with schizophrenia tend to have abnormal immune activation resulting in elevated pro-inflammatory cytokine levels, ultimately leading to functional brain impairments...
May 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28462134/new-4-substituted-benzoyl-%C3%AE-d-glycoside-from-the-fruit-pulp-of-terminalia-belerica-with-antiplatelet-and-antioxidant-potency
#3
Vaseem Ahmad Ansari, Muhammad Arif, Md Sarfaraj Hussain, Hefazat Hussain Siddiqui, Rakesh Kumar Dixit
BACKGROUND: The fruit Terminalia belerica is a rich source of vitamins, acids, and nutraceuticals which have free radical scavenging activity. Thus, the ethanolic extract of fruit and its isolated compound (Tb-01) were intended to estimate antiplatelet and antioxidant activities. METHODS: The ethanolic extract was submitted to Si-gel CC and the compound was isolated. The compound Tb-01 was characterized as benzoyl-β-D-(4'→10″ geranilanoxy)-pyranosides on the basis of spectral data [ultra violet (UV), infrared (IR), (1)H nuclear magnetic resonance (NMR), (13)C NMR, and Mass Spectroscopy] and chemical analyses...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28428001/cholesterol-and-related-sterols-autoxidation
#4
REVIEW
Chiara Zerbinati, Luigi Iuliano
Cholesterol is a unique lipid molecule providing the building block for membranes, hormone, vitamin D and bile acid synthesis. Metabolism of cholesterol involves several enzymes acting on the sterol nucleus or the iso-octyl tail. In the recent years, research interest has been focused on oxysterols, cholesterol derivatives generated by the addition of oxygen to the cholesterol backbone. Oxysterols can be produced enzymatically or by autoxidation. Autoxidation of cholesterol proceeds through type I or type II mechanisms...
April 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28242944/postharvest-chitosan-gallic-acid-and-chitosan-gallate-treatments-effects-on-shelf-life-quality-antioxidant-compounds-free-radical-scavenging-capacity-and-enzymes-activities-of-sukkari-bananas
#5
Mohamed A Awad, Adel D Al-Qurashi, Saleh A Mohamed, Reda M El-Shishtawy, Md Arfan Ali
The effect of postharvest chitosan, gallic acid (GA) and chitosan gallate (CG) dipping treatments at different concentrations on quality parameters, antioxidant compounds, free radical scavenging capacity (FRSC) and enzymes activities of 'Sukkari' bananas were studied during storage (ripening) at 20 ± 2 °C and 60-70% RH for 13 days. Weight loss and peel color index (the change from green to yellow) increased while, membrane stability index of peel tissues, pulp firmness and acidity decreased during storage...
February 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28236843/multiple-sclerosis-and-air-pollution-exposure-mechanisms-toward-brain-autoimmunity
#6
Sayed Esmaeil Mousavi, Pouria Heydarpour, Jacques Reis, Masoud Amiri, Mohammad Ali Sahraian
The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major mechanisms involved in MS pathogenesis, such as inflammatory factors expression, free radicals overproduction, the blood brain barrier (BBB) breakdown, neuroinflammation, vitamin D deficiency and mitochondrial dysfunction could also occur due to exposure to air pollutants...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28125070/chemical-characterization-and-antioxidant-potential-of-wild-ganoderma-species-from-ghana
#7
Mary Obodai, Deborah L Narh Mensah, Ângela Fernandes, Nii Korley Kortei, Matilda Dzomeku, Matthew Teegarden, Steven J Schwartz, Lillian Barros, Juanita Prempeh, Richard K Takli, Isabel C F R Ferreira
The chemical characterization and antioxidant potential of twelve wild strains of Ganoderma sp. from Ghana, nine (LS1-LS9) of which were found growing wild simultaneously on the same dying Delonix regia tree, were evaluated. Parameters evaluated included the nutritional value, composition in sugars, fatty acids, phenolic and other organic compounds and some vitamins and vitamin precursors. Antioxidant potential was evaluated by investigating reducing power, radical scavenging activity and lipid peroxidation inhibition using five in vitro assays...
January 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27853723/evaluation-of-the-protective-role-of-vitamin-c-on-the-metabolic-and-enzymatic-activities-of-the-liver-in-the-male-rats-after-exposure-to-2-45-ghz-of-wi-fi-routers
#8
F Shekoohi-Shooli, S M J Mortazavi, M B Shojaei-Fard, S Nematollahi, M Tayebi
BACKGROUND: The use of devices emitted microwave radiation such as mobile phones, wireless fidelity (Wi-Fi) routers, etc. is increased rapidly. It has caused a great concern; the researchers should identify its effects on people's health. We evaluated the protective role of Vitamin C on the metabolic and enzymatic activities of the liver after exposure to Wi-Fi routers. MATERIAL AND METHODS: 70 male Wistar rats weighing 200-250 g were randomly divided into 7 groups (10 rats in each group)...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27836663/vitamin-d-receptor-gene-foki-variant-in-diabetic-foot-ulcer-and-its-relation-with-oxidative-stress
#9
Negin Soroush, Mania Radfar, Armita Kakavand Hamidi, Mohammad Abdollahi, Mostafa Qorbani, Farideh Razi, Ensieh Nasli Esfahani, Mahsa M Amoli
PURPOSE: The patient's suffering and financial costs affiliated with Diabetic Foot Ulcer (DFU), as one of the most important complications of diabetes, are highly undesirable and this highlights the importance of preventive medicine about this disorder. Furthermore hyperglycemia causes generation of free radicals which leads to oxidative stress (OS). Hence, this study aims to examine the association between vitamin D receptor (VDR) gene FokI polymorphism and DFU in Iranian population and also its correlation with OS biomarkers...
January 30, 2017: Gene
https://www.readbyqxmd.com/read/27717330/role-of-vitamin-d3-combined-to-alginates-in-preventing-acid-and-oxidative-injury-in-cultured-gastric-epithelial-cells
#10
Francesca Uberti, Claudio Bardelli, Vera Morsanuto, Sabrina Ghirlanda, Claudio Molinari
BACKGROUND: Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury. Acid secreted from gastric parietal cells determines mucosal injuries which in turn cause inflammation and oxidative stress. Consequent inflammation produces free radicals by mitochondria thus causing lipid peroxidation, oxidative and acidic stress, which can lead to cell apoptosis...
October 7, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27665006/effects-of-dietary-vitamin-e-type-on-the-growth-performance-and-antioxidant-capacity-in-cyclophosphamide-immunosuppressed-broilers
#11
K Cheng, Z H Song, X C Zheng, H Zhang, J F Zhang, L L Zhang, Y M Zhou, T Wang
Reactive oxygen species and free radicals play multiple roles in some immune-pathological events. Vitamin E, as a very potent antioxidant, perhaps deceases the potentially negative effects of such oxidative stress to prevent immune-pathological damage to broilers. Therefore, the current study investigated the effects of dietary natural (D-α-tocopherol) and synthetic (DL-α-tocopherol acetate) vitamin E on the growth performance and antioxidant capacity in cyclophosphamide (CY) immunosuppressed broilers. 192 one-day-old male Arbor Acre broilers were randomly distributed into 4 groups: 1) non-CY-challenged control; 2) CY-challenged control; 3) CY-challenged group+20 IU DL-α-tocopherol acetate per kg feed; and 4) CY-challenged group+20 IU D-α-tocopherol per kg feed...
May 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/27487512/concentration-of-hepatic-vitamins-a-and-e-in-rats-exposed-to-chlorpyrifos-and-or-enrofloxacin
#12
A Spodniewska, D Barski
The aim of the study was to determine the level of antioxidant vitamins A and E in the liver of rats exposed to chlorpyrifos and/or enrofloxacin. Chlorpyrifos (Group I) was administered at a dose of 0.04 LD50 (6 mg/kg b.w.) for 28 days, and enrofloxacin (Group II) at a dose of 5 mg/kg b.w. for 5 consecutive days. The animals of group III were given both of the mentioned above compounds at the same manner as groups I and II, but enrofloxacin was applied to rats for the last 5 days of chlorpyrifos exposure (i...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27453278/molecular-detection-and-in-vitro-antioxidant-activity-of-s-allyl-l-cysteine-sac-extracted-from-allium-sativum
#13
Y-E Sun, W-D Wang
It is well known that Allium sativum has potential applications to clinical treatment of various cancers due to its remarkable ability in eliminating free radicals and increasing metabolism. An allyl-substituted cysteine derivative - S-allyl-L-cysteine (SAC) was separated and identified from Allium sativum. The extracted SAC was reacted with 1-pyrenemethanol to obtain pyrene-labelled SAC (Py-SAC) to give SAC fluorescence properties. Molecular detection of Py-SAC was conducted by steady-state fluorescence spectroscopy and time-resolved fluorescence method to quantitatively measure concentrations of Py-SAC solutions...
June 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27429711/new-pathogenic-concepts-and-therapeutic-approaches-to-oxidative-stress-in-chronic-kidney-disease
#14
REVIEW
José Pedraza-Chaverri, Laura G Sánchez-Lozada, Horacio Osorio-Alonso, Edilia Tapia, Alexandra Scholze
In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27414177/biological-variation-of-ascorbic-acid-and-%C3%AE-tocopherol
#15
O Lux, D Naidoo
Accumulating evidence that free radicals may contribute to various diseases, has sparked epidemiological and experimental studies of the correlation between plasma levels of antioxidant vitamins and risk to develop cancer, ischaemic heart disease and stroke. These studies often do not take into account the random biological fluctuation of the antioxidant concentration, which occurs in each individual. The weekly and monthly variability of the antioxidants ascorbic acid and α-tocopherol was studied in 12 healthy volunteers (4 women and 8 men) aged 23-45 years...
October 1994: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27332689/effect-of-topical-application-of-antioxidants-and-free-radical-scavengers-on-protection-of-hairless-mouse-skin-exposed-to-chronic-doses-of-ultraviolet-b
#16
N Muizzuddin, A R Shakoori, K D Marenus
BACKGROUND/AIMS: Within the past three decades, there has emerged a greater awareness of the molecular effects of solar rays especially ultraviolet radiation (UV-R), to the extent that the harmful effects of solar radiation are recognized not only by molecular biologists and physicians, but also by the general public (1). Various sunscreen molecules that effectively block the UVB component of the sun are available; however, a large part of Western populations elicits adverse reactions against chemical sunscreens (2)...
November 1998: Skin Research and Technology
https://www.readbyqxmd.com/read/27260571/the-effects-of-the-antioxidant-%C3%AE-tocopherol-succinate-on-cisplatin-induced-ototoxicity-in-hei-oc1-auditory-cells
#17
Sung Kyun Kim, Gi Jung Im, Yun Suk An, Se Hee Lee, Hak Hyun Jung, Sang Yoo Park
CONCLUSION: D-α-tocopherol succinate significantly reduced a cisplatin-induced hair cell loss in HEI-OC1 cell lines. These effects were mediated by its scavenging activity against reactive oxygen species (ROS) and inhibition of apoptosis. OBJECTIVES: Alpha-tocopherol is a class of methylated phenols, known as fat-soluble antioxidants, and is a different form of vitamin E, which reduces free radicals and acts as an antioxidant. We hypothesized that the antioxidative effect of α-tocopherol could protect against cisplastin-induced cytotoxicity, and thus evaluated its effects on cisplatin-induced ototoxicity in HEI-OC1 auditory cells...
July 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27252250/protective-effects-of-1%C3%AE-25-dihydroxyvitamin-d3-on-cultured-neural-cells-exposed-to-catalytic-iron
#18
Francesca Uberti, Vera Morsanuto, Claudio Bardelli, Claudio Molinari
Recent studies have postulated a role for vitamin D and its receptor on cerebral function, and anti-inflammatory, immunomodulatory and neuroprotective effects have been described; vitamin D can inhibit proinflammatory cytokines and nitric oxide synthesis during various neurodegenerative insults, and may be considered as a potential drug for the treatment of these disorders. In addition, iron is crucial for neuronal development and neurotransmitter production in the brain, but its accumulation as catalytic form (Fe(3+)) impairs brain function and causes the dysregulation of iron metabolism leading to tissue damage due to the formation of toxic free radicals (ROS)...
June 2016: Physiological Reports
https://www.readbyqxmd.com/read/27146874/effect-of-processing-and-storage-methods-on-the-nutritional-anti-nutritional-and-anti-oxidant-properties-of-paeonia-emodi-wall-ex-royle
#19
Arun Kumar Jugran, Waqar Younis Chaudhary, Amit Bahukhandi, Indra D Bhatt, Ranbeer S Rawal, Pitamber P Dhyani
Nutritional, anti-nutritional, and anti-mutagenic activities of the fresh and boiled Paeonia emodi leaves were analyzed. Significantly higher vitamin A (64.19 ± 0.18 mg/100 g), C (160.50 ± 1.85 mg/100 g), and E (1.25 ± 0.00 μg/g) contents were recorded in boiled as compared to fresh and dried juvenile leaves. Similarly, significantly higher protein content (329.63 ± 0.33 mg/100 g) was found in boiled budding leaves, carbohydrate content in fresh juvenile (0.353 ± 0.02) and mature leaves (0...
September 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/26828875/a-new-anthraquinone-glycoside-from-rhamnus-nakaharai-and-anti-tyrosinase-effect-of-6-methoxysorigenin
#20
Tzy-Ming Lu, Horng-Huey Ko
In continual study on the heartwood of Rhamnus nakaharai, a new alaternin-8-O-glucoside, namely 1,2,6,8-tetrahydroxy-3-methylanthraquinone-8-O-β-glucopyranoside (1), together with some known compounds were further isolated and characterised by 1-D, 2-D NMR and other spectral evidences. The free radical scavenging and antityrosinase activities of the isolates, including alaternin (1a), emodin (2a), emodin-8-O-β-glucopyranoside (2), 6-methoxysorigenin-8-O-β-glucopyranoside (3) and 6-methoxysorigenin (3a) were tested...
February 1, 2016: Natural Product Research
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