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vitamin d free radicals

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https://www.readbyqxmd.com/read/27853723/evaluation-of-the-protective-role-of-vitamin-c-on-the-metabolic-and-enzymatic-activities-of-the-liver-in-the-male-rats-after-exposure-to-2-45-ghz-of-wi-fi-routers
#1
F Shekoohi-Shooli, S M J Mortazavi, M B Shojaei-Fard, S Nematollahi, M Tayebi
BACKGROUND: The use of devices emitted microwave radiation such as mobile phones, wireless fidelity (Wi-Fi) routers, etc. is increased rapidly. It has caused a great concern; the researchers should identify its effects on people's health. We evaluated the protective role of Vitamin C on the metabolic and enzymatic activities of the liver after exposure to Wi-Fi routers. MATERIAL AND METHODS: 70 male Wistar rats weighing 200-250 g were randomly divided into 7 groups (10 rats in each group)...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27836663/vitamin-d-receptor-gene-foki-variant-in-diabetic-foot-ulcer-and-its-relation-with-oxidative-stress
#2
Negin Soroush, Mania Radfar, Armita Kakavand Hamidi, Mohammad Abdollahi, Mostafa Qorbani, Farideh Razi, Ensieh Nasli Esfahani, Mahsa M Amoli
PURPOSE: The patient's suffering and financial costs affiliated with Diabetic Foot Ulcer (DFU), as one of the most important complications of diabetes, are highly undesirable and this highlights the importance of preventive medicine about this disorder. Furthermore hyperglycemia causes generation of free radicals which leads to oxidative stress (OS). Hence, this study aims to examine the association between vitamin D receptor (VDR) gene FokI polymorphism and DFU in Iranian population and also its correlation with OS biomarkers...
November 9, 2016: Gene
https://www.readbyqxmd.com/read/27717330/role-of-vitamin-d3-combined-to-alginates-in-preventing-acid-and-oxidative-injury-in-cultured-gastric-epithelial-cells
#3
Francesca Uberti, Claudio Bardelli, Vera Morsanuto, Sabrina Ghirlanda, Claudio Molinari
BACKGROUND: Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury. Acid secreted from gastric parietal cells determines mucosal injuries which in turn cause inflammation and oxidative stress. Consequent inflammation produces free radicals by mitochondria thus causing lipid peroxidation, oxidative and acidic stress, which can lead to cell apoptosis...
October 7, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27665006/effects-of-dietary-vitamin-e-type-on-the-growth-performance-and-antioxidant-capacity-in-cyclophosphamide-immunosuppressed-broilers
#4
K Cheng, Z H Song, X C Zheng, H Zhang, J F Zhang, L L Zhang, Y M Zhou, T Wang
Reactive oxygen species and free radicals play multiple roles in some immune-pathological events. Vitamin E, as a very potent antioxidant, perhaps deceases the potentially negative effects of such oxidative stress to prevent immune-pathological damage to broilers. Therefore, the current study investigated the effects of dietary natural (D-α-tocopherol) and synthetic (DL-α-tocopherol acetate) vitamin E on the growth performance and antioxidant capacity in cyclophosphamide (CY) immunosuppressed broilers. 192 one-day-old male Arbor Acre broilers were randomly distributed into 4 groups: 1) non-CY-challenged control; 2) CY-challenged control; 3) CY-challenged group+20 IU DL-α-tocopherol acetate per kg feed; and 4) CY-challenged group+20 IU D-α-tocopherol per kg feed...
September 24, 2016: Poultry Science
https://www.readbyqxmd.com/read/27487512/concentration-of-hepatic-vitamins-a-and-e-in-rats-exposed-to-chlorpyrifos-and-or-enrofloxacin
#5
A Spodniewska, D Barski
The aim of the study was to determine the level of antioxidant vitamins A and E in the liver of rats exposed to chlorpyrifos and/or enrofloxacin. Chlorpyrifos (Group I) was administered at a dose of 0.04 LD50 (6 mg/kg b.w.) for 28 days, and enrofloxacin (Group II) at a dose of 5 mg/kg b.w. for 5 consecutive days. The animals of group III were given both of the mentioned above compounds at the same manner as groups I and II, but enrofloxacin was applied to rats for the last 5 days of chlorpyrifos exposure (i...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27453278/molecular-detection-and-in-vitro-antioxidant-activity-of-s-allyl-l-cysteine-sac-extracted-from-allium-sativum
#6
Y-E Sun, W-D Wang
It is well known that Allium sativum has potential applications to clinical treatment of various cancers due to its remarkable ability in eliminating free radicals and increasing metabolism. An allyl-substituted cysteine derivative - S-allyl-L-cysteine (SAC) was separated and identified from Allium sativum. The extracted SAC was reacted with 1-pyrenemethanol to obtain pyrene-labelled SAC (Py-SAC) to give SAC fluorescence properties. Molecular detection of Py-SAC was conducted by steady-state fluorescence spectroscopy and time-resolved fluorescence method to quantitatively measure concentrations of Py-SAC solutions...
2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27429711/new-pathogenic-concepts-and-therapeutic-approaches-to-oxidative-stress-in-chronic-kidney-disease
#7
REVIEW
José Pedraza-Chaverri, Laura G Sánchez-Lozada, Horacio Osorio-Alonso, Edilia Tapia, Alexandra Scholze
In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27414177/biological-variation-of-ascorbic-acid-and-%C3%AE-tocopherol
#8
O Lux, D Naidoo
Accumulating evidence that free radicals may contribute to various diseases, has sparked epidemiological and experimental studies of the correlation between plasma levels of antioxidant vitamins and risk to develop cancer, ischaemic heart disease and stroke. These studies often do not take into account the random biological fluctuation of the antioxidant concentration, which occurs in each individual. The weekly and monthly variability of the antioxidants ascorbic acid and α-tocopherol was studied in 12 healthy volunteers (4 women and 8 men) aged 23-45 years...
October 1994: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27332689/effect-of-topical-application-of-antioxidants-and-free-radical-scavengers-on-protection-of-hairless-mouse-skin-exposed-to-chronic-doses-of-ultraviolet-b
#9
N Muizzuddin, A R Shakoori, K D Marenus
BACKGROUND/AIMS: Within the past three decades, there has emerged a greater awareness of the molecular effects of solar rays especially ultraviolet radiation (UV-R), to the extent that the harmful effects of solar radiation are recognized not only by molecular biologists and physicians, but also by the general public (1). Various sunscreen molecules that effectively block the UVB component of the sun are available; however, a large part of Western populations elicits adverse reactions against chemical sunscreens (2)...
November 1998: Skin Research and Technology
https://www.readbyqxmd.com/read/27260571/the-effects-of-the-antioxidant-%C3%AE-tocopherol-succinate-on-cisplatin-induced-ototoxicity-in-hei-oc1-auditory-cells
#10
Sung Kyun Kim, Gi Jung Im, Yun Suk An, Se Hee Lee, Hak Hyun Jung, Sang Yoo Park
CONCLUSION: D-α-tocopherol succinate significantly reduced a cisplatin-induced hair cell loss in HEI-OC1 cell lines. These effects were mediated by its scavenging activity against reactive oxygen species (ROS) and inhibition of apoptosis. OBJECTIVES: Alpha-tocopherol is a class of methylated phenols, known as fat-soluble antioxidants, and is a different form of vitamin E, which reduces free radicals and acts as an antioxidant. We hypothesized that the antioxidative effect of α-tocopherol could protect against cisplastin-induced cytotoxicity, and thus evaluated its effects on cisplatin-induced ototoxicity in HEI-OC1 auditory cells...
July 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27252250/protective-effects-of-1%C3%AE-25-dihydroxyvitamin-d3-on-cultured-neural-cells-exposed-to-catalytic-iron
#11
Francesca Uberti, Vera Morsanuto, Claudio Bardelli, Claudio Molinari
Recent studies have postulated a role for vitamin D and its receptor on cerebral function, and anti-inflammatory, immunomodulatory and neuroprotective effects have been described; vitamin D can inhibit proinflammatory cytokines and nitric oxide synthesis during various neurodegenerative insults, and may be considered as a potential drug for the treatment of these disorders. In addition, iron is crucial for neuronal development and neurotransmitter production in the brain, but its accumulation as catalytic form (Fe(3+)) impairs brain function and causes the dysregulation of iron metabolism leading to tissue damage due to the formation of toxic free radicals (ROS)...
June 2016: Physiological Reports
https://www.readbyqxmd.com/read/27146874/effect-of-processing-and-storage-methods-on-the-nutritional-anti-nutritional-and-anti-oxidant-properties-of-paeonia-emodi-wall-ex-royle
#12
Arun Kumar Jugran, Waqar Younis Chaudhary, Amit Bahukhandi, Indra D Bhatt, Ranbeer S Rawal, Pitamber P Dhyani
Nutritional, anti-nutritional, and anti-mutagenic activities of the fresh and boiled Paeonia emodi leaves were analyzed. Significantly higher vitamin A (64.19 ± 0.18 mg/100 g), C (160.50 ± 1.85 mg/100 g), and E (1.25 ± 0.00 μg/g) contents were recorded in boiled as compared to fresh and dried juvenile leaves. Similarly, significantly higher protein content (329.63 ± 0.33 mg/100 g) was found in boiled budding leaves, carbohydrate content in fresh juvenile (0.353 ± 0.02) and mature leaves (0...
September 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/26828875/a-new-anthraquinone-glycoside-from-rhamnus-nakaharai-and-anti-tyrosinase-effect-of-6-methoxysorigenin
#13
Tzy-Ming Lu, Horng-Huey Ko
In continual study on the heartwood of Rhamnus nakaharai, a new alaternin-8-O-glucoside, namely 1,2,6,8-tetrahydroxy-3-methylanthraquinone-8-O-β-glucopyranoside (1), together with some known compounds were further isolated and characterised by 1-D, 2-D NMR and other spectral evidences. The free radical scavenging and antityrosinase activities of the isolates, including alaternin (1a), emodin (2a), emodin-8-O-β-glucopyranoside (2), 6-methoxysorigenin-8-O-β-glucopyranoside (3) and 6-methoxysorigenin (3a) were tested...
February 1, 2016: Natural Product Research
https://www.readbyqxmd.com/read/26805810/antiproliferative-effects-of-new-dimeric-ellagitannin-from-cornus-alba-in-prostate-cancer-cells-including-apoptosis-related-s-phase-arrest
#14
Kwan Hee Park, Jun Yin, Ki Hoon Yoon, Yoon Jeong Hwang, Min Won Lee
Activity-guided isolation of 80% acetone extract of Cornus alba, which is traditionally used as an anti-inflammatory, hemostatic and diuretic in Korea, yielded one novel compound, tentatively designated cornusiin H (13), together with 12 known compounds. The known compounds included four flavonoids (catechin (1), quercetin-3-O-β-D-glucuronide (2), quercetin-3-O-β-D-glucopyranoside (3), kaempferol-3-O-β-D-glucopyranoside (4)) and eight hydrolysable tannins (gallic acid (5), 2,6-di-O-galloyl-hamamelofuranoside (6), 2-galloyl-4-caffeoyl-L-threonic acid (7) 2,3-di-O-galloyl-4-caffeoyl-L-threonic acid (8), 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranoside (9), cornusiin B (10), cornusiin A (11) and camptothin B (12))...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26709186/a-novel-strain-of-lactobacillus-mucosae-isolated-from-a-gaotian-villager-improves-in-vitro-and-in-vivo-antioxidant-as-well-as-biological-properties-in-d-galactose-induced-aging-mice
#15
Xiaomin Yu, Shengjie Li, Dong Yang, Liang Qiu, Yaoping Wu, Dengyuan Wang, Nagendra P Shah, Feng Xu, Hua Wei
Twelve isolates isolated from the gastrointestinal tracts of Gaotian villagers in China, who had a lifespan of 92 yr, were examined for their antioxidants using free radical scavenging activity and 2,2-diphenyl-1-picrylhydrazyl. Three strains (i.e., Lactobacillus mucosae LMU1001, and Lactobacillus plantarum LPL0902 and LPL0302) were selected as candidates to prepare yogurt for testing their antioxidants in a model of d-galactose-induced aging mice, with vitamin C as a positive control. The results showed that L...
February 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/26664481/the-evaluation-of-non-enzymatic-antioxidants-effects-in-limiting-tumor-associated-oxidative-stress-in-a-tumor-rat-model
#16
R Grigorescu, M I Gruia, V Nacea, C Nitu, V Negoita, D Glavan
Active oxygen species are produced as a consequence of normal aerobic metabolism. Of these, free radicals are usually metabolized or inactivated in vivo by a team of antioxidants. Individual members are a trained team fighting antioxidants to prevent the generation of ROS, destroy or oxidizing potential of capture. In terms of physiological oxidative stress, induced tissue attack is minimal. A relative or absolute deficiency in the antioxidant defense may lead to increased oxidative stress and this event is associated with both the causes and consequences of diseases and cancer, included here...
October 2015: Journal of Medicine and Life
https://www.readbyqxmd.com/read/26610529/interactions-between-carotenoids-from-marine-bacteria-and-other-micronutrients-impact-on-stability-and-antioxidant-activity
#17
Charlotte Sy, Olivier Dangles, Patrick Borel, Catherine Caris-Veyrat
Recently isolated spore-forming pigmented marine bacteria Bacillus indicus HU36 are sources of oxygenated carotenoids with original structures (about fifteen distinct yellow and orange pigments with acylated d-glucosyl groups). In this study, we evaluated the stability (sensitivity to iron-induced autoxidation) and antioxidant activity (inhibition of iron-induced lipid peroxidation) of combinations of bacterial HU36 carotenoids with the bacterial vitamin menaquinone MQ-7 and with phenolic antioxidants (vitamin E, chlorogenic acid, rutin)...
November 2015: Marine Drugs
https://www.readbyqxmd.com/read/26562741/indoline-amide-glucosides-from-portulaca-oleracea-isolation-structure-and-dpph-radical-scavenging-activity
#18
Ze-Zhao Jiao, Su Yue, Hong-Xiang Sun, Tian-Yun Jin, Hai-Na Wang, Rong-Xiu Zhu, Lan Xiang
A polyamide column chromatography method using an aqueous ammonia mobile phase was developed for large-scale accumulation of water-soluble indoline amide glucosides from a medicinal plant, Portulaca oleracea. Ten new [oleraceins H, I, K, L, N, O, P, Q, R, S (1-10)] and four known [oleraceins A-D (11-14)] indoline amide glucosides were further purified and structurally characterized by various chromatographic and spectroscopic methods. The DPPH radical scavenging activities of oleraceins K (5) and L (6), with EC50 values of 15...
November 25, 2015: Journal of Natural Products
https://www.readbyqxmd.com/read/26559860/chemical-composition-and-medicinal-value-of-the-new-ganoderma-tsugae-var-jannieae-cbs-120304-medicinal-higher-basidiomycete-mushroom
#19
Jannie Siew Lee Chan, Mikheil D Asatiani, Lital E Sharvit, Beny Trabelcy, Gayane S Barseghyan, Solomon P Wasser
In this research, the chemical composition and anticancer and antioxidant activity of the new medicinal mushroom Ganoderma tsugae var. jannieae CBS-120304 were evaluated. The chemical composition assay includes amounts of total carbohydrates and proteins, amino acids, fatty acids, micro- and macroelements, and vitamins. The investigated medicinal mushroom seemed to be a rich source of nutritional components. Mycelium accumulated more than 2-fold more total protein compared with the fruiting body and reached 37% and 16% of dry weight, respectively...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/26409185/oxidative-stress-type-2-diabetes-and-vitamin-d-past-present-and-future
#20
REVIEW
Bahareh Nikooyeh, Tirang R Neyestani
Oxidative stress refers to an imbalance between potentially harmful free radicals and the body's mechanisms to efficiently detoxify them in favor of the free radicals. Consequently, excess free radicals can attack and damage a wide range of biomolecules including proteins, lipids and nucleic acids. Antioxidant mechanisms of the body are under the influence of genetic and environmental (including dietary) factors. Diabetes is one of the most common metabolic disorders around the world. A huge body of evidence indicates a role for oxidative stress in development of many human diseases including diabetes...
March 2016: Diabetes/metabolism Research and Reviews
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